-- dump date   	20140619_012931
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
331272000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
331272000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
331272000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272000004	Walker A motif; other site
331272000005	ATP binding site [chemical binding]; other site
331272000006	Walker B motif; other site
331272000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
331272000008	arginine finger; other site
331272000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
331272000010	DnaA box-binding interface [nucleotide binding]; other site
331272000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
331272000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
331272000013	putative DNA binding surface [nucleotide binding]; other site
331272000014	dimer interface [polypeptide binding]; other site
331272000015	beta-clamp/clamp loader binding surface; other site
331272000016	beta-clamp/translesion DNA polymerase binding surface; other site
331272000017	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
331272000018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272000019	ATP binding site [chemical binding]; other site
331272000020	Mg2+ binding site [ion binding]; other site
331272000021	G-X-G motif; other site
331272000022	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
331272000023	anchoring element; other site
331272000024	dimer interface [polypeptide binding]; other site
331272000025	ATP binding site [chemical binding]; other site
331272000026	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
331272000027	active site
331272000028	putative metal-binding site [ion binding]; other site
331272000029	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
331272000030	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
331272000031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272000032	Integrase core domain; Region: rve; pfam00665
331272000033	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
331272000034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272000035	Walker A motif; other site
331272000036	ATP binding site [chemical binding]; other site
331272000037	Walker B motif; other site
331272000038	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
331272000039	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331272000040	DNA-binding interface [nucleotide binding]; DNA binding site
331272000041	HTH-like domain; Region: HTH_21; pfam13276
331272000042	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
331272000043	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
331272000044	putative heme binding pocket [chemical binding]; other site
331272000045	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272000046	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272000047	DNA binding residues [nucleotide binding]
331272000048	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
331272000049	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
331272000050	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
331272000051	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272000052	Uncharacterized conserved protein [Function unknown]; Region: COG2128
331272000053	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272000054	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
331272000055	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
331272000056	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
331272000057	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
331272000058	Restriction endonuclease [Defense mechanisms]; Region: COG3587
331272000059	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272000060	ATP binding site [chemical binding]; other site
331272000061	putative Mg++ binding site [ion binding]; other site
331272000062	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
331272000063	DNA methylase; Region: N6_N4_Mtase; pfam01555
331272000064	DNA methylase; Region: N6_N4_Mtase; cl17433
331272000065	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272000066	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272000067	trimer interface [polypeptide binding]; other site
331272000068	eyelet of channel; other site
331272000069	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
331272000070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272000071	active site
331272000072	phosphorylation site [posttranslational modification]
331272000073	intermolecular recognition site; other site
331272000074	dimerization interface [polypeptide binding]; other site
331272000075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272000076	DNA binding site [nucleotide binding]
331272000077	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
331272000078	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272000079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272000080	dimer interface [polypeptide binding]; other site
331272000081	phosphorylation site [posttranslational modification]
331272000082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272000083	ATP binding site [chemical binding]; other site
331272000084	Mg2+ binding site [ion binding]; other site
331272000085	G-X-G motif; other site
331272000086	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272000087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272000088	dimer interface [polypeptide binding]; other site
331272000089	conserved gate region; other site
331272000090	putative PBP binding loops; other site
331272000091	ABC-ATPase subunit interface; other site
331272000092	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272000093	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272000094	Walker A/P-loop; other site
331272000095	ATP binding site [chemical binding]; other site
331272000096	Q-loop/lid; other site
331272000097	ABC transporter signature motif; other site
331272000098	Walker B; other site
331272000099	D-loop; other site
331272000100	H-loop/switch region; other site
331272000101	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272000102	NMT1/THI5 like; Region: NMT1; pfam09084
331272000103	membrane-bound complex binding site; other site
331272000104	hinge residues; other site
331272000105	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
331272000106	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
331272000107	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
331272000108	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
331272000109	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
331272000110	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
331272000111	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
331272000112	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
331272000113	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
331272000114	LrgA family; Region: LrgA; pfam03788
331272000115	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272000116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000117	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
331272000118	putative dimerization interface [polypeptide binding]; other site
331272000119	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
331272000120	putative active site [active]
331272000121	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
331272000122	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272000123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000124	putative substrate translocation pore; other site
331272000125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000126	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272000127	MarR family; Region: MarR_2; cl17246
331272000128	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272000129	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
331272000130	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
331272000131	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
331272000132	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
331272000133	GspL periplasmic domain; Region: GspL_C; pfam12693
331272000134	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
331272000135	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
331272000136	type II secretion system protein I; Region: gspI; TIGR01707
331272000137	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
331272000138	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
331272000139	Type II transport protein GspH; Region: GspH; pfam12019
331272000140	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
331272000141	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
331272000142	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
331272000143	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
331272000144	type II secretion system protein F; Region: GspF; TIGR02120
331272000145	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272000146	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272000147	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
331272000148	type II secretion system protein E; Region: type_II_gspE; TIGR02533
331272000149	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
331272000150	Walker A motif; other site
331272000151	ATP binding site [chemical binding]; other site
331272000152	Walker B motif; other site
331272000153	type II secretion system protein D; Region: type_II_gspD; TIGR02517
331272000154	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272000155	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272000156	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272000157	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
331272000158	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331272000159	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272000160	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272000161	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272000162	catalytic residue [active]
331272000163	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
331272000164	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
331272000165	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
331272000166	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
331272000167	IHF dimer interface [polypeptide binding]; other site
331272000168	IHF - DNA interface [nucleotide binding]; other site
331272000169	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
331272000170	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
331272000171	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272000172	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
331272000173	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
331272000174	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
331272000175	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272000176	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272000177	putative DNA binding site [nucleotide binding]; other site
331272000178	putative Zn2+ binding site [ion binding]; other site
331272000179	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
331272000180	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
331272000181	catalytic triad [active]
331272000182	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272000183	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
331272000184	active site
331272000185	FMN binding site [chemical binding]; other site
331272000186	substrate binding site [chemical binding]; other site
331272000187	homotetramer interface [polypeptide binding]; other site
331272000188	catalytic residue [active]
331272000189	Proteins containing SET domain [General function prediction only]; Region: COG2940
331272000190	SET domain; Region: SET; pfam00856
331272000191	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
331272000192	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272000193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272000194	dimer interface [polypeptide binding]; other site
331272000195	phosphorylation site [posttranslational modification]
331272000196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272000197	ATP binding site [chemical binding]; other site
331272000198	Mg2+ binding site [ion binding]; other site
331272000199	G-X-G motif; other site
331272000200	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272000201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272000202	active site
331272000203	phosphorylation site [posttranslational modification]
331272000204	intermolecular recognition site; other site
331272000205	dimerization interface [polypeptide binding]; other site
331272000206	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272000207	DNA binding site [nucleotide binding]
331272000208	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
331272000209	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
331272000210	aromatic arch; other site
331272000211	DCoH dimer interaction site [polypeptide binding]; other site
331272000212	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
331272000213	DCoH tetramer interaction site [polypeptide binding]; other site
331272000214	substrate binding site [chemical binding]; other site
331272000215	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
331272000216	cofactor binding site; other site
331272000217	metal binding site [ion binding]; metal-binding site
331272000218	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272000219	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272000220	putative DNA binding site [nucleotide binding]; other site
331272000221	putative Zn2+ binding site [ion binding]; other site
331272000222	AsnC family; Region: AsnC_trans_reg; pfam01037
331272000223	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
331272000224	putative active site [active]
331272000225	putative metal binding residues [ion binding]; other site
331272000226	signature motif; other site
331272000227	putative triphosphate binding site [ion binding]; other site
331272000228	dimer interface [polypeptide binding]; other site
331272000229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272000230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000231	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272000232	dimerization interface [polypeptide binding]; other site
331272000233	choline dehydrogenase; Validated; Region: PRK02106
331272000234	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272000235	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272000236	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272000237	Walker A/P-loop; other site
331272000238	ATP binding site [chemical binding]; other site
331272000239	Q-loop/lid; other site
331272000240	ABC transporter signature motif; other site
331272000241	Walker B; other site
331272000242	D-loop; other site
331272000243	H-loop/switch region; other site
331272000244	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272000245	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272000246	Walker A/P-loop; other site
331272000247	ATP binding site [chemical binding]; other site
331272000248	Q-loop/lid; other site
331272000249	ABC transporter signature motif; other site
331272000250	Walker B; other site
331272000251	D-loop; other site
331272000252	H-loop/switch region; other site
331272000253	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
331272000254	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
331272000255	putative ligand binding site [chemical binding]; other site
331272000256	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272000257	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272000258	TM-ABC transporter signature motif; other site
331272000259	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272000260	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272000261	TM-ABC transporter signature motif; other site
331272000262	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272000263	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
331272000264	putative ligand binding site [chemical binding]; other site
331272000265	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272000266	TM-ABC transporter signature motif; other site
331272000267	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272000268	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272000269	TM-ABC transporter signature motif; other site
331272000270	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272000271	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272000272	Walker A/P-loop; other site
331272000273	ATP binding site [chemical binding]; other site
331272000274	Q-loop/lid; other site
331272000275	ABC transporter signature motif; other site
331272000276	Walker B; other site
331272000277	D-loop; other site
331272000278	H-loop/switch region; other site
331272000279	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272000280	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272000281	Walker A/P-loop; other site
331272000282	ATP binding site [chemical binding]; other site
331272000283	Q-loop/lid; other site
331272000284	ABC transporter signature motif; other site
331272000285	Walker B; other site
331272000286	D-loop; other site
331272000287	H-loop/switch region; other site
331272000288	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
331272000289	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
331272000290	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
331272000291	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
331272000292	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
331272000293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272000294	S-adenosylmethionine binding site [chemical binding]; other site
331272000295	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331272000296	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272000297	P-loop; other site
331272000298	Magnesium ion binding site [ion binding]; other site
331272000299	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272000300	Magnesium ion binding site [ion binding]; other site
331272000301	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
331272000302	ParB-like nuclease domain; Region: ParBc; pfam02195
331272000303	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
331272000304	transmembrane helices; other site
331272000305	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
331272000306	ATP synthase I chain; Region: ATP_synt_I; cl09170
331272000307	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
331272000308	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
331272000309	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
331272000310	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
331272000311	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
331272000312	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
331272000313	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
331272000314	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
331272000315	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
331272000316	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
331272000317	beta subunit interaction interface [polypeptide binding]; other site
331272000318	Walker A motif; other site
331272000319	ATP binding site [chemical binding]; other site
331272000320	Walker B motif; other site
331272000321	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
331272000322	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
331272000323	core domain interface [polypeptide binding]; other site
331272000324	delta subunit interface [polypeptide binding]; other site
331272000325	epsilon subunit interface [polypeptide binding]; other site
331272000326	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
331272000327	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
331272000328	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
331272000329	alpha subunit interaction interface [polypeptide binding]; other site
331272000330	Walker A motif; other site
331272000331	ATP binding site [chemical binding]; other site
331272000332	Walker B motif; other site
331272000333	inhibitor binding site; inhibition site
331272000334	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
331272000335	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
331272000336	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
331272000337	gamma subunit interface [polypeptide binding]; other site
331272000338	epsilon subunit interface [polypeptide binding]; other site
331272000339	LBP interface [polypeptide binding]; other site
331272000340	AMP-binding domain protein; Validated; Region: PRK08315
331272000341	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272000342	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
331272000343	acyl-activating enzyme (AAE) consensus motif; other site
331272000344	putative AMP binding site [chemical binding]; other site
331272000345	putative active site [active]
331272000346	putative CoA binding site [chemical binding]; other site
331272000347	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272000348	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272000349	substrate binding pocket [chemical binding]; other site
331272000350	membrane-bound complex binding site; other site
331272000351	hinge residues; other site
331272000352	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
331272000353	substrate binding site [chemical binding]; other site
331272000354	active site
331272000355	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
331272000356	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272000357	ATP binding site [chemical binding]; other site
331272000358	putative Mg++ binding site [ion binding]; other site
331272000359	helicase superfamily c-terminal domain; Region: HELICc; smart00490
331272000360	nucleotide binding region [chemical binding]; other site
331272000361	ATP-binding site [chemical binding]; other site
331272000362	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
331272000363	Predicted transcriptional regulator [Transcription]; Region: COG3905
331272000364	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
331272000365	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
331272000366	Glutamate binding site [chemical binding]; other site
331272000367	NAD binding site [chemical binding]; other site
331272000368	catalytic residues [active]
331272000369	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272000370	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272000371	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272000372	dimerization interface [polypeptide binding]; other site
331272000373	ligand binding site [chemical binding]; other site
331272000374	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
331272000375	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272000376	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
331272000377	acyl-activating enzyme (AAE) consensus motif; other site
331272000378	acyl-activating enzyme (AAE) consensus motif; other site
331272000379	putative AMP binding site [chemical binding]; other site
331272000380	putative active site [active]
331272000381	putative CoA binding site [chemical binding]; other site
331272000382	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
331272000383	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272000384	active site
331272000385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272000386	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272000387	putative aminotransferase; Provisional; Region: PRK12414
331272000388	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272000389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272000390	homodimer interface [polypeptide binding]; other site
331272000391	catalytic residue [active]
331272000392	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272000393	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272000394	substrate binding pocket [chemical binding]; other site
331272000395	membrane-bound complex binding site; other site
331272000396	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272000397	FAD binding domain; Region: FAD_binding_4; pfam01565
331272000398	Predicted transcriptional regulators [Transcription]; Region: COG1695
331272000399	Transcriptional regulator PadR-like family; Region: PadR; cl17335
331272000400	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
331272000401	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
331272000402	DNA binding residues [nucleotide binding]
331272000403	dimer interface [polypeptide binding]; other site
331272000404	putative metal binding site [ion binding]; other site
331272000405	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
331272000406	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
331272000407	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331272000408	Soluble P-type ATPase [General function prediction only]; Region: COG4087
331272000409	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
331272000410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272000411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272000412	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
331272000413	Conserved TM helix; Region: TM_helix; pfam05552
331272000414	ethanolamine permease; Region: 2A0305; TIGR00908
331272000415	hypothetical protein; Provisional; Region: PHA02764
331272000416	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
331272000417	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
331272000418	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
331272000419	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272000420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000421	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
331272000422	putative effector binding pocket; other site
331272000423	putative dimerization interface [polypeptide binding]; other site
331272000424	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272000425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000426	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
331272000427	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
331272000428	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272000429	NAD(P) binding site [chemical binding]; other site
331272000430	catalytic residues [active]
331272000431	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
331272000432	transcriptional regulator EutR; Provisional; Region: PRK10130
331272000433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272000434	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272000435	thiamine pyrophosphate protein; Validated; Region: PRK08199
331272000436	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272000437	PYR/PP interface [polypeptide binding]; other site
331272000438	dimer interface [polypeptide binding]; other site
331272000439	TPP binding site [chemical binding]; other site
331272000440	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272000441	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
331272000442	TPP-binding site [chemical binding]; other site
331272000443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
331272000444	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
331272000445	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
331272000446	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
331272000447	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
331272000448	Alginate lyase; Region: Alginate_lyase; pfam05426
331272000449	glycine dehydrogenase; Provisional; Region: PRK05367
331272000450	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272000451	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272000452	catalytic residue [active]
331272000453	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
331272000454	tetramer interface [polypeptide binding]; other site
331272000455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272000456	catalytic residue [active]
331272000457	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
331272000458	lipoyl attachment site [posttranslational modification]; other site
331272000459	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
331272000460	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
331272000461	putative oxidoreductase; Provisional; Region: PRK11579
331272000462	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272000463	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
331272000464	active site
331272000465	catalytic triad [active]
331272000466	oxyanion hole [active]
331272000467	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
331272000468	Part of AAA domain; Region: AAA_19; pfam13245
331272000469	Family description; Region: UvrD_C_2; pfam13538
331272000470	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
331272000471	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
331272000472	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
331272000473	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272000474	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272000475	dimer interface [polypeptide binding]; other site
331272000476	putative CheW interface [polypeptide binding]; other site
331272000477	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272000478	trimer interface [polypeptide binding]; other site
331272000479	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272000480	eyelet of channel; other site
331272000481	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272000482	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272000483	DNA-binding site [nucleotide binding]; DNA binding site
331272000484	FCD domain; Region: FCD; pfam07729
331272000485	Domain of unknown function (DUF336); Region: DUF336; cl01249
331272000486	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272000487	N-terminal, non-catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Rhodococcus rhodochrous K37, and similar proteins; Region: BphC5-RrK37_N_like; cd08362
331272000488	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
331272000489	putative oligomer interface [polypeptide binding]; other site
331272000490	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
331272000491	putative active site [active]
331272000492	Mn binding site [ion binding]; other site
331272000493	putative oligomer interface [polypeptide binding]; other site
331272000494	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272000495	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272000496	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
331272000497	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272000498	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272000499	benzoate transport; Region: 2A0115; TIGR00895
331272000500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000502	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272000503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000504	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
331272000505	putative substrate binding pocket [chemical binding]; other site
331272000506	putative dimerization interface [polypeptide binding]; other site
331272000507	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
331272000508	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272000509	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272000510	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272000511	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272000512	active site
331272000513	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
331272000514	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
331272000515	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272000516	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272000517	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331272000518	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331272000519	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
331272000520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272000521	classical (c) SDRs; Region: SDR_c; cd05233
331272000522	NAD(P) binding site [chemical binding]; other site
331272000523	active site
331272000524	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
331272000525	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
331272000526	acyl-activating enzyme (AAE) consensus motif; other site
331272000527	active site
331272000528	AMP binding site [chemical binding]; other site
331272000529	substrate binding site [chemical binding]; other site
331272000530	enoyl-CoA hydratase; Provisional; Region: PRK05870
331272000531	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272000532	substrate binding site [chemical binding]; other site
331272000533	oxyanion hole (OAH) forming residues; other site
331272000534	trimer interface [polypeptide binding]; other site
331272000535	enoyl-CoA hydratase; Provisional; Region: PRK06494
331272000536	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272000537	substrate binding site [chemical binding]; other site
331272000538	oxyanion hole (OAH) forming residues; other site
331272000539	trimer interface [polypeptide binding]; other site
331272000540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272000541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272000542	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
331272000543	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
331272000544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000545	putative substrate translocation pore; other site
331272000546	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272000547	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272000548	trimer interface [polypeptide binding]; other site
331272000549	eyelet of channel; other site
331272000550	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272000551	Carboxylesterase family; Region: COesterase; pfam00135
331272000552	substrate binding pocket [chemical binding]; other site
331272000553	catalytic triad [active]
331272000554	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272000555	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272000556	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
331272000557	NmrA-like family; Region: NmrA; pfam05368
331272000558	NAD(P) binding site [chemical binding]; other site
331272000559	active site lysine
331272000560	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
331272000561	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272000562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272000563	non-specific DNA binding site [nucleotide binding]; other site
331272000564	salt bridge; other site
331272000565	sequence-specific DNA binding site [nucleotide binding]; other site
331272000566	Domain of unknown function (DUF955); Region: DUF955; cl01076
331272000567	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272000568	Sel1-like repeats; Region: SEL1; smart00671
331272000569	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272000570	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272000571	non-specific DNA binding site [nucleotide binding]; other site
331272000572	salt bridge; other site
331272000573	sequence-specific DNA binding site [nucleotide binding]; other site
331272000574	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
331272000575	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
331272000576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272000577	Walker A/P-loop; other site
331272000578	ATP binding site [chemical binding]; other site
331272000579	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
331272000580	putative active site [active]
331272000581	putative metal-binding site [ion binding]; other site
331272000582	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
331272000583	Part of AAA domain; Region: AAA_19; pfam13245
331272000584	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
331272000585	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331272000586	active site
331272000587	catalytic residues [active]
331272000588	DNA binding site [nucleotide binding]
331272000589	Int/Topo IB signature motif; other site
331272000590	TniQ; Region: TniQ; pfam06527
331272000591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272000592	sequence-specific DNA binding site [nucleotide binding]; other site
331272000593	salt bridge; other site
331272000594	AAA domain; Region: AAA_22; pfam13401
331272000595	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
331272000596	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
331272000597	Integrase core domain; Region: rve; pfam00665
331272000598	Methyltransferase domain; Region: Methyltransf_26; pfam13659
331272000599	DEAD/DEAH box helicase; Region: DEAD; pfam00270
331272000600	helicase superfamily c-terminal domain; Region: HELICc; smart00490
331272000601	ATP-binding site [chemical binding]; other site
331272000602	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
331272000603	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
331272000604	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
331272000605	Domain of unknown function (DUF955); Region: DUF955; pfam06114
331272000606	Uncharacterized conserved protein [Function unknown]; Region: COG4278
331272000607	TIGR04222 domain; Region: near_uncomplex
331272000608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272000609	TPR motif; other site
331272000610	binding surface
331272000611	TPR repeat; Region: TPR_11; pfam13414
331272000612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272000613	binding surface
331272000614	TPR motif; other site
331272000615	TPR repeat; Region: TPR_11; pfam13414
331272000616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272000617	WbqC-like protein family; Region: WbqC; pfam08889
331272000618	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331272000619	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272000620	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
331272000621	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
331272000622	inhibitor-cofactor binding pocket; inhibition site
331272000623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272000624	catalytic residue [active]
331272000625	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331272000626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272000627	TPR motif; other site
331272000628	binding surface
331272000629	TPR repeat; Region: TPR_11; pfam13414
331272000630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272000631	TPR motif; other site
331272000632	binding surface
331272000633	TPR repeat; Region: TPR_11; pfam13414
331272000634	flagellar capping protein; Reviewed; Region: fliD; PRK08032
331272000635	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
331272000636	flagellin; Reviewed; Region: PRK08869
331272000637	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
331272000638	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
331272000639	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
331272000640	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272000641	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272000642	N-terminal plug; other site
331272000643	ligand-binding site [chemical binding]; other site
331272000644	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
331272000645	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
331272000646	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
331272000647	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
331272000648	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
331272000649	putative hydrolase; Provisional; Region: PRK10976
331272000650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272000651	active site
331272000652	motif I; other site
331272000653	motif II; other site
331272000654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
331272000655	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
331272000656	amphipathic channel; other site
331272000657	Asn-Pro-Ala signature motifs; other site
331272000658	H-NS histone family; Region: Histone_HNS; pfam00816
331272000659	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272000660	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
331272000661	putative ADP-binding pocket [chemical binding]; other site
331272000662	transcriptional activator FlhD; Provisional; Region: PRK02909
331272000663	transcriptional activator FlhC; Provisional; Region: PRK12722
331272000664	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
331272000665	flagellar motor protein MotA; Validated; Region: PRK09110
331272000666	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
331272000667	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
331272000668	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272000669	ligand binding site [chemical binding]; other site
331272000670	Response regulator receiver domain; Region: Response_reg; pfam00072
331272000671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272000672	active site
331272000673	phosphorylation site [posttranslational modification]
331272000674	intermolecular recognition site; other site
331272000675	dimerization interface [polypeptide binding]; other site
331272000676	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
331272000677	putative binding surface; other site
331272000678	active site
331272000679	CheY binding; Region: CheY-binding; pfam09078
331272000680	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
331272000681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272000682	ATP binding site [chemical binding]; other site
331272000683	Mg2+ binding site [ion binding]; other site
331272000684	G-X-G motif; other site
331272000685	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
331272000686	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
331272000687	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272000688	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
331272000689	dimer interface [polypeptide binding]; other site
331272000690	ligand binding site [chemical binding]; other site
331272000691	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272000692	dimerization interface [polypeptide binding]; other site
331272000693	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272000694	dimer interface [polypeptide binding]; other site
331272000695	putative CheW interface [polypeptide binding]; other site
331272000696	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
331272000697	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
331272000698	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
331272000699	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489
331272000700	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
331272000701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272000702	active site
331272000703	phosphorylation site [posttranslational modification]
331272000704	intermolecular recognition site; other site
331272000705	dimerization interface [polypeptide binding]; other site
331272000706	CheB methylesterase; Region: CheB_methylest; pfam01339
331272000707	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
331272000708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272000709	active site
331272000710	phosphorylation site [posttranslational modification]
331272000711	intermolecular recognition site; other site
331272000712	dimerization interface [polypeptide binding]; other site
331272000713	chemotaxis regulator CheZ; Provisional; Region: PRK11166
331272000714	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
331272000715	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
331272000716	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
331272000717	dimer interface [polypeptide binding]; other site
331272000718	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
331272000719	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
331272000720	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
331272000721	FHIPEP family; Region: FHIPEP; pfam00771
331272000722	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722
331272000723	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331272000724	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
331272000725	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
331272000726	P-loop; other site
331272000727	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
331272000728	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272000729	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
331272000730	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272000731	DNA binding residues [nucleotide binding]
331272000732	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
331272000733	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
331272000734	homotetramer interface [polypeptide binding]; other site
331272000735	ligand binding site [chemical binding]; other site
331272000736	catalytic site [active]
331272000737	NAD binding site [chemical binding]; other site
331272000738	Predicted membrane protein [Function unknown]; Region: COG1950
331272000739	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
331272000740	FAD binding site [chemical binding]; other site
331272000741	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331272000742	Amidase; Region: Amidase; cl11426
331272000743	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
331272000744	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
331272000745	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
331272000746	FMN binding site [chemical binding]; other site
331272000747	substrate binding site [chemical binding]; other site
331272000748	putative catalytic residue [active]
331272000749	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272000750	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272000751	dimerization interface [polypeptide binding]; other site
331272000752	ligand binding site [chemical binding]; other site
331272000753	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
331272000754	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
331272000755	H-NS histone family; Region: Histone_HNS; pfam00816
331272000756	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272000757	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
331272000758	Cation efflux family; Region: Cation_efflux; pfam01545
331272000759	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272000760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272000761	putative DNA binding site [nucleotide binding]; other site
331272000762	putative Zn2+ binding site [ion binding]; other site
331272000763	AsnC family; Region: AsnC_trans_reg; pfam01037
331272000764	active site
331272000765	catalytic site [active]
331272000766	substrate binding site [chemical binding]; other site
331272000767	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
331272000768	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
331272000769	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
331272000770	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
331272000771	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
331272000772	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
331272000773	putative active site [active]
331272000774	putative NTP binding site [chemical binding]; other site
331272000775	putative nucleic acid binding site [nucleotide binding]; other site
331272000776	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
331272000777	Predicted methyltransferases [General function prediction only]; Region: COG0313
331272000778	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
331272000779	putative SAM binding site [chemical binding]; other site
331272000780	putative homodimer interface [polypeptide binding]; other site
331272000781	hypothetical protein; Provisional; Region: PRK14673
331272000782	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
331272000783	active site
331272000784	dimer interface [polypeptide binding]; other site
331272000785	outer membrane lipoprotein; Provisional; Region: PRK11023
331272000786	BON domain; Region: BON; pfam04972
331272000787	BON domain; Region: BON; cl02771
331272000788	Cytochrome c; Region: Cytochrom_C; cl11414
331272000789	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
331272000790	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
331272000791	active site
331272000792	tetramer interface [polypeptide binding]; other site
331272000793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272000794	D-galactonate transporter; Region: 2A0114; TIGR00893
331272000795	putative substrate translocation pore; other site
331272000796	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272000797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000798	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272000799	putative effector binding pocket; other site
331272000800	dimerization interface [polypeptide binding]; other site
331272000801	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272000802	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
331272000803	C-terminal domain interface [polypeptide binding]; other site
331272000804	GSH binding site (G-site) [chemical binding]; other site
331272000805	dimer interface [polypeptide binding]; other site
331272000806	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
331272000807	N-terminal domain interface [polypeptide binding]; other site
331272000808	dimer interface [polypeptide binding]; other site
331272000809	substrate binding pocket (H-site) [chemical binding]; other site
331272000810	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
331272000811	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
331272000812	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
331272000813	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331272000814	FtsX-like permease family; Region: FtsX; pfam02687
331272000815	Predicted permease; Region: FtsX; cl11418
331272000816	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331272000817	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331272000818	Walker A/P-loop; other site
331272000819	ATP binding site [chemical binding]; other site
331272000820	Q-loop/lid; other site
331272000821	ABC transporter signature motif; other site
331272000822	Walker B; other site
331272000823	D-loop; other site
331272000824	H-loop/switch region; other site
331272000825	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272000826	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272000827	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
331272000828	Uncharacterized conserved protein [Function unknown]; Region: COG1656
331272000829	Protein of unknown function DUF82; Region: DUF82; pfam01927
331272000830	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272000831	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272000832	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272000833	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272000834	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272000835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272000836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272000837	dimerization interface [polypeptide binding]; other site
331272000838	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
331272000839	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
331272000840	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
331272000841	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
331272000842	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
331272000843	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
331272000844	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272000845	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
331272000846	substrate binding site [chemical binding]; other site
331272000847	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272000848	active site
331272000849	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
331272000850	Malic enzyme, N-terminal domain; Region: malic; pfam00390
331272000851	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
331272000852	putative NAD(P) binding site [chemical binding]; other site
331272000853	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
331272000854	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
331272000855	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
331272000856	dimer interface [polypeptide binding]; other site
331272000857	PYR/PP interface [polypeptide binding]; other site
331272000858	TPP binding site [chemical binding]; other site
331272000859	substrate binding site [chemical binding]; other site
331272000860	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
331272000861	TPP-binding site; other site
331272000862	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
331272000863	Sfi1 spindle body protein; Region: Sfi1; pfam08457
331272000864	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
331272000865	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
331272000866	dimer interface [polypeptide binding]; other site
331272000867	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
331272000868	active site
331272000869	Fe binding site [ion binding]; other site
331272000870	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272000871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272000872	putative DNA binding site [nucleotide binding]; other site
331272000873	putative Zn2+ binding site [ion binding]; other site
331272000874	AsnC family; Region: AsnC_trans_reg; pfam01037
331272000875	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272000876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272000877	Coenzyme A binding pocket [chemical binding]; other site
331272000878	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272000879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272000880	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
331272000881	Protein of unknown function; Region: DUF3658; pfam12395
331272000882	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
331272000883	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
331272000884	FAD binding pocket [chemical binding]; other site
331272000885	FAD binding motif [chemical binding]; other site
331272000886	phosphate binding motif [ion binding]; other site
331272000887	beta-alpha-beta structure motif; other site
331272000888	NAD(p) ribose binding residues [chemical binding]; other site
331272000889	NAD binding pocket [chemical binding]; other site
331272000890	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
331272000891	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272000892	catalytic loop [active]
331272000893	iron binding site [ion binding]; other site
331272000894	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
331272000895	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
331272000896	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
331272000897	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
331272000898	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
331272000899	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
331272000900	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
331272000901	active site
331272000902	catalytic triad [active]
331272000903	oxyanion hole [active]
331272000904	elongation factor Tu; Reviewed; Region: PRK00049
331272000905	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
331272000906	G1 box; other site
331272000907	GEF interaction site [polypeptide binding]; other site
331272000908	GTP/Mg2+ binding site [chemical binding]; other site
331272000909	Switch I region; other site
331272000910	G2 box; other site
331272000911	G3 box; other site
331272000912	Switch II region; other site
331272000913	G4 box; other site
331272000914	G5 box; other site
331272000915	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
331272000916	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
331272000917	Antibiotic Binding Site [chemical binding]; other site
331272000918	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
331272000919	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
331272000920	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
331272000921	putative homodimer interface [polypeptide binding]; other site
331272000922	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
331272000923	heterodimer interface [polypeptide binding]; other site
331272000924	homodimer interface [polypeptide binding]; other site
331272000925	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
331272000926	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
331272000927	23S rRNA interface [nucleotide binding]; other site
331272000928	L7/L12 interface [polypeptide binding]; other site
331272000929	putative thiostrepton binding site; other site
331272000930	L25 interface [polypeptide binding]; other site
331272000931	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
331272000932	mRNA/rRNA interface [nucleotide binding]; other site
331272000933	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
331272000934	23S rRNA interface [nucleotide binding]; other site
331272000935	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
331272000936	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
331272000937	peripheral dimer interface [polypeptide binding]; other site
331272000938	core dimer interface [polypeptide binding]; other site
331272000939	L10 interface [polypeptide binding]; other site
331272000940	L11 interface [polypeptide binding]; other site
331272000941	putative EF-Tu interaction site [polypeptide binding]; other site
331272000942	putative EF-G interaction site [polypeptide binding]; other site
331272000943	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
331272000944	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
331272000945	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
331272000946	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
331272000947	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
331272000948	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
331272000949	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
331272000950	RPB3 interaction site [polypeptide binding]; other site
331272000951	RPB1 interaction site [polypeptide binding]; other site
331272000952	RPB11 interaction site [polypeptide binding]; other site
331272000953	RPB10 interaction site [polypeptide binding]; other site
331272000954	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
331272000955	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
331272000956	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
331272000957	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
331272000958	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
331272000959	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
331272000960	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
331272000961	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
331272000962	DNA binding site [nucleotide binding]
331272000963	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
331272000964	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
331272000965	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272000966	ATP binding site [chemical binding]; other site
331272000967	putative Mg++ binding site [ion binding]; other site
331272000968	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272000969	nucleotide binding region [chemical binding]; other site
331272000970	ATP-binding site [chemical binding]; other site
331272000971	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
331272000972	HRDC domain; Region: HRDC; pfam00570
331272000973	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
331272000974	S17 interaction site [polypeptide binding]; other site
331272000975	S8 interaction site; other site
331272000976	16S rRNA interaction site [nucleotide binding]; other site
331272000977	streptomycin interaction site [chemical binding]; other site
331272000978	23S rRNA interaction site [nucleotide binding]; other site
331272000979	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
331272000980	30S ribosomal protein S7; Validated; Region: PRK05302
331272000981	elongation factor G; Reviewed; Region: PRK00007
331272000982	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
331272000983	G1 box; other site
331272000984	putative GEF interaction site [polypeptide binding]; other site
331272000985	GTP/Mg2+ binding site [chemical binding]; other site
331272000986	Switch I region; other site
331272000987	G2 box; other site
331272000988	G3 box; other site
331272000989	Switch II region; other site
331272000990	G4 box; other site
331272000991	G5 box; other site
331272000992	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
331272000993	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
331272000994	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
331272000995	elongation factor Tu; Reviewed; Region: PRK00049
331272000996	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
331272000997	G1 box; other site
331272000998	GEF interaction site [polypeptide binding]; other site
331272000999	GTP/Mg2+ binding site [chemical binding]; other site
331272001000	Switch I region; other site
331272001001	G2 box; other site
331272001002	G3 box; other site
331272001003	Switch II region; other site
331272001004	G4 box; other site
331272001005	G5 box; other site
331272001006	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
331272001007	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
331272001008	Antibiotic Binding Site [chemical binding]; other site
331272001009	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
331272001010	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
331272001011	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
331272001012	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
331272001013	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
331272001014	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
331272001015	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
331272001016	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
331272001017	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
331272001018	putative translocon binding site; other site
331272001019	protein-rRNA interface [nucleotide binding]; other site
331272001020	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
331272001021	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
331272001022	G-X-X-G motif; other site
331272001023	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
331272001024	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
331272001025	23S rRNA interface [nucleotide binding]; other site
331272001026	5S rRNA interface [nucleotide binding]; other site
331272001027	putative antibiotic binding site [chemical binding]; other site
331272001028	L25 interface [polypeptide binding]; other site
331272001029	L27 interface [polypeptide binding]; other site
331272001030	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
331272001031	23S rRNA interface [nucleotide binding]; other site
331272001032	putative translocon interaction site; other site
331272001033	signal recognition particle (SRP54) interaction site; other site
331272001034	L23 interface [polypeptide binding]; other site
331272001035	trigger factor interaction site; other site
331272001036	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
331272001037	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
331272001038	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
331272001039	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
331272001040	RNA binding site [nucleotide binding]; other site
331272001041	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
331272001042	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
331272001043	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
331272001044	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
331272001045	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
331272001046	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
331272001047	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
331272001048	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
331272001049	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
331272001050	5S rRNA interface [nucleotide binding]; other site
331272001051	L27 interface [polypeptide binding]; other site
331272001052	23S rRNA interface [nucleotide binding]; other site
331272001053	L5 interface [polypeptide binding]; other site
331272001054	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
331272001055	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
331272001056	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
331272001057	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
331272001058	23S rRNA binding site [nucleotide binding]; other site
331272001059	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
331272001060	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
331272001061	SecY translocase; Region: SecY; pfam00344
331272001062	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
331272001063	rRNA binding site [nucleotide binding]; other site
331272001064	predicted 30S ribosome binding site; other site
331272001065	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
331272001066	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
331272001067	30S ribosomal protein S13; Region: bact_S13; TIGR03631
331272001068	30S ribosomal protein S11; Validated; Region: PRK05309
331272001069	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
331272001070	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
331272001071	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272001072	RNA binding surface [nucleotide binding]; other site
331272001073	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
331272001074	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
331272001075	alphaNTD homodimer interface [polypeptide binding]; other site
331272001076	alphaNTD - beta interaction site [polypeptide binding]; other site
331272001077	alphaNTD - beta' interaction site [polypeptide binding]; other site
331272001078	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
331272001079	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
331272001080	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
331272001081	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
331272001082	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
331272001083	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
331272001084	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
331272001085	DsbD alpha interface [polypeptide binding]; other site
331272001086	catalytic residues [active]
331272001087	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
331272001088	dimer interface [polypeptide binding]; other site
331272001089	active site
331272001090	aspartate-rich active site metal binding site; other site
331272001091	allosteric magnesium binding site [ion binding]; other site
331272001092	Schiff base residues; other site
331272001093	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
331272001094	G1 box; other site
331272001095	GTP/Mg2+ binding site [chemical binding]; other site
331272001096	Switch I region; other site
331272001097	G2 box; other site
331272001098	G3 box; other site
331272001099	Switch II region; other site
331272001100	G4 box; other site
331272001101	G5 box; other site
331272001102	Cytochrome c553 [Energy production and conversion]; Region: COG2863
331272001103	Cytochrome c; Region: Cytochrom_C; cl11414
331272001104	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
331272001105	ResB-like family; Region: ResB; pfam05140
331272001106	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
331272001107	ResB-like family; Region: ResB; pfam05140
331272001108	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
331272001109	TMAO/DMSO reductase; Reviewed; Region: PRK05363
331272001110	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
331272001111	Moco binding site; other site
331272001112	metal coordination site [ion binding]; other site
331272001113	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
331272001114	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
331272001115	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
331272001116	putative iron binding site [ion binding]; other site
331272001117	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
331272001118	Transglycosylase; Region: Transgly; pfam00912
331272001119	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
331272001120	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
331272001121	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
331272001122	Secretin and TonB N terminus short domain; Region: STN; pfam07660
331272001123	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272001124	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331272001125	shikimate kinase; Reviewed; Region: aroK; PRK00131
331272001126	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
331272001127	ADP binding site [chemical binding]; other site
331272001128	magnesium binding site [ion binding]; other site
331272001129	putative shikimate binding site; other site
331272001130	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
331272001131	active site
331272001132	dimer interface [polypeptide binding]; other site
331272001133	metal binding site [ion binding]; metal-binding site
331272001134	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
331272001135	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272001136	Zn2+ binding site [ion binding]; other site
331272001137	Mg2+ binding site [ion binding]; other site
331272001138	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
331272001139	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272001140	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
331272001141	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
331272001142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272001143	dimer interface [polypeptide binding]; other site
331272001144	conserved gate region; other site
331272001145	putative PBP binding loops; other site
331272001146	ABC-ATPase subunit interface; other site
331272001147	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272001148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272001149	dimer interface [polypeptide binding]; other site
331272001150	conserved gate region; other site
331272001151	putative PBP binding loops; other site
331272001152	ABC-ATPase subunit interface; other site
331272001153	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
331272001154	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272001155	Walker A/P-loop; other site
331272001156	ATP binding site [chemical binding]; other site
331272001157	Q-loop/lid; other site
331272001158	ABC transporter signature motif; other site
331272001159	Walker B; other site
331272001160	D-loop; other site
331272001161	H-loop/switch region; other site
331272001162	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
331272001163	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
331272001164	active site
331272001165	catalytic site [active]
331272001166	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
331272001167	Transposase IS200 like; Region: Y1_Tnp; cl00848
331272001168	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
331272001169	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
331272001170	active site
331272001171	dimer interface [polypeptide binding]; other site
331272001172	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
331272001173	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
331272001174	active site
331272001175	FMN binding site [chemical binding]; other site
331272001176	substrate binding site [chemical binding]; other site
331272001177	3Fe-4S cluster binding site [ion binding]; other site
331272001178	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
331272001179	domain interface; other site
331272001180	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
331272001181	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272001182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272001183	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
331272001184	amino acid carrier protein; Region: agcS; TIGR00835
331272001185	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
331272001186	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
331272001187	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272001188	benzoate transport; Region: 2A0115; TIGR00895
331272001189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272001190	putative substrate translocation pore; other site
331272001191	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
331272001192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272001193	NAD(P) binding site [chemical binding]; other site
331272001194	active site
331272001195	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
331272001196	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
331272001197	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
331272001198	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
331272001199	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
331272001200	sulfur carrier protein ThiS; Provisional; Region: PRK06944
331272001201	charged pocket; other site
331272001202	hydrophobic patch; other site
331272001203	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
331272001204	ThiS interaction site; other site
331272001205	putative active site [active]
331272001206	tetramer interface [polypeptide binding]; other site
331272001207	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
331272001208	thiamine phosphate binding site [chemical binding]; other site
331272001209	active site
331272001210	pyrophosphate binding site [ion binding]; other site
331272001211	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
331272001212	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
331272001213	Walker A/P-loop; other site
331272001214	ATP binding site [chemical binding]; other site
331272001215	Q-loop/lid; other site
331272001216	ABC transporter signature motif; other site
331272001217	Walker B; other site
331272001218	D-loop; other site
331272001219	H-loop/switch region; other site
331272001220	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
331272001221	Permease; Region: Permease; pfam02405
331272001222	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
331272001223	mce related protein; Region: MCE; pfam02470
331272001224	VacJ like lipoprotein; Region: VacJ; cl01073
331272001225	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
331272001226	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
331272001227	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
331272001228	Walker A/P-loop; other site
331272001229	ATP binding site [chemical binding]; other site
331272001230	Q-loop/lid; other site
331272001231	ABC transporter signature motif; other site
331272001232	Walker B; other site
331272001233	D-loop; other site
331272001234	H-loop/switch region; other site
331272001235	ABC-2 type transporter; Region: ABC2_membrane; cl17235
331272001236	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
331272001237	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
331272001238	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
331272001239	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
331272001240	hinge; other site
331272001241	active site
331272001242	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
331272001243	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
331272001244	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
331272001245	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
331272001246	NAD binding site [chemical binding]; other site
331272001247	dimerization interface [polypeptide binding]; other site
331272001248	product binding site; other site
331272001249	substrate binding site [chemical binding]; other site
331272001250	zinc binding site [ion binding]; other site
331272001251	catalytic residues [active]
331272001252	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
331272001253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272001254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272001255	homodimer interface [polypeptide binding]; other site
331272001256	catalytic residue [active]
331272001257	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
331272001258	putative active site pocket [active]
331272001259	4-fold oligomerization interface [polypeptide binding]; other site
331272001260	metal binding residues [ion binding]; metal-binding site
331272001261	3-fold/trimer interface [polypeptide binding]; other site
331272001262	MarC family integral membrane protein; Region: MarC; cl00919
331272001263	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
331272001264	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
331272001265	putative active site [active]
331272001266	oxyanion strand; other site
331272001267	catalytic triad [active]
331272001268	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
331272001269	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
331272001270	catalytic residues [active]
331272001271	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
331272001272	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
331272001273	substrate binding site [chemical binding]; other site
331272001274	glutamase interaction surface [polypeptide binding]; other site
331272001275	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
331272001276	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
331272001277	metal binding site [ion binding]; metal-binding site
331272001278	Predicted membrane protein [Function unknown]; Region: COG3671
331272001279	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
331272001280	nucleotide binding site/active site [active]
331272001281	HIT family signature motif; other site
331272001282	catalytic residue [active]
331272001283	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
331272001284	sec-independent translocase; Provisional; Region: tatB; PRK01919
331272001285	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
331272001286	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
331272001287	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331272001288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272001289	protein binding site [polypeptide binding]; other site
331272001290	Uncharacterized conserved protein [Function unknown]; Region: COG0327
331272001291	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
331272001292	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
331272001293	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
331272001294	[2Fe-2S] cluster binding site [ion binding]; other site
331272001295	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
331272001296	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
331272001297	Qi binding site; other site
331272001298	intrachain domain interface; other site
331272001299	interchain domain interface [polypeptide binding]; other site
331272001300	heme bH binding site [chemical binding]; other site
331272001301	heme bL binding site [chemical binding]; other site
331272001302	Qo binding site; other site
331272001303	interchain domain interface [polypeptide binding]; other site
331272001304	intrachain domain interface; other site
331272001305	Qi binding site; other site
331272001306	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
331272001307	Qo binding site; other site
331272001308	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
331272001309	stringent starvation protein A; Provisional; Region: sspA; PRK09481
331272001310	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
331272001311	C-terminal domain interface [polypeptide binding]; other site
331272001312	putative GSH binding site (G-site) [chemical binding]; other site
331272001313	dimer interface [polypeptide binding]; other site
331272001314	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
331272001315	dimer interface [polypeptide binding]; other site
331272001316	N-terminal domain interface [polypeptide binding]; other site
331272001317	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
331272001318	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
331272001319	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
331272001320	catalytic residues [active]
331272001321	Int/Topo IB signature motif; other site
331272001322	Helix-turn-helix domain; Region: HTH_36; pfam13730
331272001323	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
331272001324	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
331272001325	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272001326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272001327	substrate binding pocket [chemical binding]; other site
331272001328	membrane-bound complex binding site; other site
331272001329	hinge residues; other site
331272001330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272001331	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272001332	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272001333	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272001334	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272001335	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331272001336	RHS Repeat; Region: RHS_repeat; pfam05593
331272001337	RHS Repeat; Region: RHS_repeat; pfam05593
331272001338	RHS Repeat; Region: RHS_repeat; pfam05593
331272001339	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331272001340	RHS Repeat; Region: RHS_repeat; pfam05593
331272001341	RHS Repeat; Region: RHS_repeat; pfam05593
331272001342	RHS Repeat; Region: RHS_repeat; pfam05593
331272001343	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
331272001344	RHS protein; Region: RHS; pfam03527
331272001345	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331272001346	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
331272001347	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
331272001348	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
331272001349	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
331272001350	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
331272001351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272001352	TPR motif; other site
331272001353	binding surface
331272001354	Protein of unknown function (DUF770); Region: DUF770; pfam05591
331272001355	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
331272001356	Protein of unknown function (DUF877); Region: DUF877; pfam05943
331272001357	Protein of unknown function (DUF796); Region: DUF796; pfam05638
331272001358	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
331272001359	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
331272001360	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
331272001361	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
331272001362	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
331272001363	Clp amino terminal domain; Region: Clp_N; pfam02861
331272001364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272001365	Walker A motif; other site
331272001366	ATP binding site [chemical binding]; other site
331272001367	Walker B motif; other site
331272001368	arginine finger; other site
331272001369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272001370	Walker A motif; other site
331272001371	ATP binding site [chemical binding]; other site
331272001372	Walker B motif; other site
331272001373	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
331272001374	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
331272001375	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
331272001376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272001377	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272001378	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272001379	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272001380	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272001381	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
331272001382	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
331272001383	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
331272001384	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
331272001385	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
331272001386	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272001387	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272001388	ligand binding site [chemical binding]; other site
331272001389	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
331272001390	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
331272001391	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272001392	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272001393	ligand binding site [chemical binding]; other site
331272001394	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
331272001395	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
331272001396	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
331272001397	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
331272001398	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
331272001399	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
331272001400	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
331272001401	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
331272001402	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
331272001403	Cl binding site [ion binding]; other site
331272001404	oligomer interface [polypeptide binding]; other site
331272001405	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
331272001406	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272001407	NAD(P) binding site [chemical binding]; other site
331272001408	transcriptional activator TtdR; Provisional; Region: PRK09801
331272001409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272001410	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272001411	putative effector binding pocket; other site
331272001412	dimerization interface [polypeptide binding]; other site
331272001413	Peptidase family M1; Region: Peptidase_M1; pfam01433
331272001414	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
331272001415	Zn binding site [ion binding]; other site
331272001416	Water Stress and Hypersensitive response; Region: WHy; smart00769
331272001417	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
331272001418	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
331272001419	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
331272001420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272001421	S-adenosylmethionine binding site [chemical binding]; other site
331272001422	Methyltransferase domain; Region: Methyltransf_32; pfam13679
331272001423	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
331272001424	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272001425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272001426	D-galactonate transporter; Region: 2A0114; TIGR00893
331272001427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272001428	putative substrate translocation pore; other site
331272001429	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
331272001430	putative FMN binding site [chemical binding]; other site
331272001431	putative chaperone; Provisional; Region: PRK11678
331272001432	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
331272001433	nucleotide binding site [chemical binding]; other site
331272001434	putative NEF/HSP70 interaction site [polypeptide binding]; other site
331272001435	SBD interface [polypeptide binding]; other site
331272001436	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272001437	DNA-binding site [nucleotide binding]; DNA binding site
331272001438	RNA-binding motif; other site
331272001439	amino acid transporter; Region: 2A0306; TIGR00909
331272001440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272001441	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272001442	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272001443	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
331272001444	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
331272001445	putative active site [active]
331272001446	metal binding site [ion binding]; metal-binding site
331272001447	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
331272001448	Flavoprotein; Region: Flavoprotein; pfam02441
331272001449	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
331272001450	putative GSH binding site [chemical binding]; other site
331272001451	catalytic residues [active]
331272001452	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
331272001453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272001454	S-adenosylmethionine binding site [chemical binding]; other site
331272001455	peptide chain release factor 1; Validated; Region: prfA; PRK00591
331272001456	This domain is found in peptide chain release factors; Region: PCRF; smart00937
331272001457	RF-1 domain; Region: RF-1; pfam00472
331272001458	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
331272001459	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
331272001460	tRNA; other site
331272001461	putative tRNA binding site [nucleotide binding]; other site
331272001462	putative NADP binding site [chemical binding]; other site
331272001463	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
331272001464	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272001465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272001466	active site
331272001467	phosphorylation site [posttranslational modification]
331272001468	intermolecular recognition site; other site
331272001469	dimerization interface [polypeptide binding]; other site
331272001470	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272001471	DNA binding site [nucleotide binding]
331272001472	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
331272001473	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
331272001474	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
331272001475	active site
331272001476	Isochorismatase family; Region: Isochorismatase; pfam00857
331272001477	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
331272001478	catalytic triad [active]
331272001479	conserved cis-peptide bond; other site
331272001480	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
331272001481	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
331272001482	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
331272001483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272001484	Walker A/P-loop; other site
331272001485	ATP binding site [chemical binding]; other site
331272001486	Q-loop/lid; other site
331272001487	ABC transporter signature motif; other site
331272001488	Walker B; other site
331272001489	D-loop; other site
331272001490	H-loop/switch region; other site
331272001491	ABC transporter; Region: ABC_tran_2; pfam12848
331272001492	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272001493	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
331272001494	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272001495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272001496	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272001497	dimerization interface [polypeptide binding]; other site
331272001498	substrate binding pocket [chemical binding]; other site
331272001499	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
331272001500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272001501	putative substrate translocation pore; other site
331272001502	Protein of unknown function (DUF419); Region: DUF419; cl15265
331272001503	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
331272001504	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
331272001505	GTP-binding protein YchF; Reviewed; Region: PRK09601
331272001506	YchF GTPase; Region: YchF; cd01900
331272001507	G1 box; other site
331272001508	GTP/Mg2+ binding site [chemical binding]; other site
331272001509	Switch I region; other site
331272001510	G2 box; other site
331272001511	Switch II region; other site
331272001512	G3 box; other site
331272001513	G4 box; other site
331272001514	G5 box; other site
331272001515	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
331272001516	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
331272001517	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
331272001518	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
331272001519	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
331272001520	dimerization domain [polypeptide binding]; other site
331272001521	dimer interface [polypeptide binding]; other site
331272001522	catalytic residues [active]
331272001523	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
331272001524	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
331272001525	PDZ domain; Region: PDZ_2; pfam13180
331272001526	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
331272001527	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272001528	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
331272001529	ligand binding site [chemical binding]; other site
331272001530	active site
331272001531	UGI interface [polypeptide binding]; other site
331272001532	catalytic site [active]
331272001533	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
331272001534	putative active site [active]
331272001535	putative metal binding residues [ion binding]; other site
331272001536	signature motif; other site
331272001537	putative triphosphate binding site [ion binding]; other site
331272001538	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
331272001539	active site
331272001540	ribulose/triose binding site [chemical binding]; other site
331272001541	phosphate binding site [ion binding]; other site
331272001542	substrate (anthranilate) binding pocket [chemical binding]; other site
331272001543	product (indole) binding pocket [chemical binding]; other site
331272001544	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
331272001545	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
331272001546	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
331272001547	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
331272001548	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
331272001549	glutamine binding [chemical binding]; other site
331272001550	catalytic triad [active]
331272001551	anthranilate synthase component I; Provisional; Region: PRK13565
331272001552	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
331272001553	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
331272001554	phosphoglycolate phosphatase; Provisional; Region: PRK13222
331272001555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
331272001556	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272001557	motif II; other site
331272001558	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
331272001559	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
331272001560	substrate binding site [chemical binding]; other site
331272001561	hexamer interface [polypeptide binding]; other site
331272001562	metal binding site [ion binding]; metal-binding site
331272001563	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
331272001564	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
331272001565	MltA specific insert domain; Region: MltA; smart00925
331272001566	3D domain; Region: 3D; pfam06725
331272001567	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
331272001568	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
331272001569	active site
331272001570	AMP binding site [chemical binding]; other site
331272001571	homodimer interface [polypeptide binding]; other site
331272001572	acyl-activating enzyme (AAE) consensus motif; other site
331272001573	CoA binding site [chemical binding]; other site
331272001574	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
331272001575	CoenzymeA binding site [chemical binding]; other site
331272001576	subunit interaction site [polypeptide binding]; other site
331272001577	PHB binding site; other site
331272001578	enoyl-CoA hydratase; Provisional; Region: PRK08140
331272001579	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272001580	substrate binding site [chemical binding]; other site
331272001581	oxyanion hole (OAH) forming residues; other site
331272001582	trimer interface [polypeptide binding]; other site
331272001583	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
331272001584	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272001585	dimer interface [polypeptide binding]; other site
331272001586	active site
331272001587	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
331272001588	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272001589	NAD(P) binding site [chemical binding]; other site
331272001590	catalytic residues [active]
331272001591	enoyl-CoA hydratase; Provisional; Region: PRK05862
331272001592	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272001593	substrate binding site [chemical binding]; other site
331272001594	oxyanion hole (OAH) forming residues; other site
331272001595	trimer interface [polypeptide binding]; other site
331272001596	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
331272001597	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
331272001598	putative [4Fe-4S] binding site [ion binding]; other site
331272001599	putative molybdopterin cofactor binding site [chemical binding]; other site
331272001600	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
331272001601	putative molybdopterin cofactor binding site; other site
331272001602	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
331272001603	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
331272001604	acyl-activating enzyme (AAE) consensus motif; other site
331272001605	putative AMP binding site [chemical binding]; other site
331272001606	putative active site [active]
331272001607	putative CoA binding site [chemical binding]; other site
331272001608	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272001609	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272001610	trimer interface [polypeptide binding]; other site
331272001611	eyelet of channel; other site
331272001612	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
331272001613	diiron binding motif [ion binding]; other site
331272001614	cell division protein MraZ; Reviewed; Region: PRK00326
331272001615	MraZ protein; Region: MraZ; pfam02381
331272001616	MraZ protein; Region: MraZ; pfam02381
331272001617	MraW methylase family; Region: Methyltransf_5; cl17771
331272001618	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
331272001619	Cell division protein FtsL; Region: FtsL; cl11433
331272001620	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
331272001621	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
331272001622	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
331272001623	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
331272001624	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272001625	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272001626	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
331272001627	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331272001628	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272001629	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272001630	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
331272001631	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
331272001632	Mg++ binding site [ion binding]; other site
331272001633	putative catalytic motif [active]
331272001634	putative substrate binding site [chemical binding]; other site
331272001635	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
331272001636	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272001637	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272001638	cell division protein FtsW; Region: ftsW; TIGR02614
331272001639	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
331272001640	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
331272001641	active site
331272001642	homodimer interface [polypeptide binding]; other site
331272001643	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
331272001644	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331272001645	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272001646	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272001647	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
331272001648	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
331272001649	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331272001650	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
331272001651	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
331272001652	Cell division protein FtsQ; Region: FtsQ; pfam03799
331272001653	cell division protein FtsA; Region: ftsA; TIGR01174
331272001654	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
331272001655	nucleotide binding site [chemical binding]; other site
331272001656	Cell division protein FtsA; Region: FtsA; pfam14450
331272001657	cell division protein FtsZ; Validated; Region: PRK09330
331272001658	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
331272001659	nucleotide binding site [chemical binding]; other site
331272001660	SulA interaction site; other site
331272001661	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
331272001662	catalytic triad [active]
331272001663	dimer interface [polypeptide binding]; other site
331272001664	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
331272001665	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
331272001666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272001667	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272001668	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272001669	Protein of unknown function (DUF721); Region: DUF721; pfam05258
331272001670	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
331272001671	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
331272001672	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
331272001673	SEC-C motif; Region: SEC-C; pfam02810
331272001674	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
331272001675	heterotetramer interface [polypeptide binding]; other site
331272001676	active site pocket [active]
331272001677	cleavage site
331272001678	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
331272001679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272001680	Walker A motif; other site
331272001681	ATP binding site [chemical binding]; other site
331272001682	Walker B motif; other site
331272001683	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
331272001684	active site
331272001685	8-oxo-dGMP binding site [chemical binding]; other site
331272001686	nudix motif; other site
331272001687	metal binding site [ion binding]; metal-binding site
331272001688	Domain of unknown function (DUF329); Region: DUF329; pfam03884
331272001689	hypothetical protein; Provisional; Region: PRK05287
331272001690	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
331272001691	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
331272001692	CoA-binding site [chemical binding]; other site
331272001693	ATP-binding [chemical binding]; other site
331272001694	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
331272001695	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
331272001696	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
331272001697	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272001698	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272001699	Type II/IV secretion system protein; Region: T2SE; pfam00437
331272001700	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
331272001701	Walker A motif; other site
331272001702	ATP binding site [chemical binding]; other site
331272001703	Walker B motif; other site
331272001704	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
331272001705	Domain of unknown function DUF21; Region: DUF21; pfam01595
331272001706	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331272001707	Transporter associated domain; Region: CorC_HlyC; smart01091
331272001708	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
331272001709	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
331272001710	substrate binding pocket [chemical binding]; other site
331272001711	chain length determination region; other site
331272001712	substrate-Mg2+ binding site; other site
331272001713	catalytic residues [active]
331272001714	aspartate-rich region 1; other site
331272001715	active site lid residues [active]
331272001716	aspartate-rich region 2; other site
331272001717	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
331272001718	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
331272001719	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
331272001720	GTPase CgtA; Reviewed; Region: obgE; PRK12299
331272001721	GTP1/OBG; Region: GTP1_OBG; pfam01018
331272001722	Obg GTPase; Region: Obg; cd01898
331272001723	G1 box; other site
331272001724	GTP/Mg2+ binding site [chemical binding]; other site
331272001725	Switch I region; other site
331272001726	G2 box; other site
331272001727	G3 box; other site
331272001728	Switch II region; other site
331272001729	G4 box; other site
331272001730	G5 box; other site
331272001731	gamma-glutamyl kinase; Provisional; Region: PRK05429
331272001732	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
331272001733	nucleotide binding site [chemical binding]; other site
331272001734	homotetrameric interface [polypeptide binding]; other site
331272001735	putative phosphate binding site [ion binding]; other site
331272001736	putative allosteric binding site; other site
331272001737	PUA domain; Region: PUA; pfam01472
331272001738	CNP1-like family; Region: CNP1; pfam08750
331272001739	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
331272001740	putative active site [active]
331272001741	Ap4A binding site [chemical binding]; other site
331272001742	nudix motif; other site
331272001743	putative metal binding site [ion binding]; other site
331272001744	prolyl-tRNA synthetase; Provisional; Region: PRK09194
331272001745	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
331272001746	dimer interface [polypeptide binding]; other site
331272001747	motif 1; other site
331272001748	active site
331272001749	motif 2; other site
331272001750	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
331272001751	putative deacylase active site [active]
331272001752	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
331272001753	active site
331272001754	motif 3; other site
331272001755	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
331272001756	anticodon binding site; other site
331272001757	MarC family integral membrane protein; Region: MarC; cl00919
331272001758	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272001759	active site
331272001760	signal recognition particle protein; Provisional; Region: PRK10867
331272001761	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
331272001762	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
331272001763	P loop; other site
331272001764	GTP binding site [chemical binding]; other site
331272001765	Signal peptide binding domain; Region: SRP_SPB; pfam02978
331272001766	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
331272001767	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
331272001768	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
331272001769	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
331272001770	amidase catalytic site [active]
331272001771	Zn binding residues [ion binding]; other site
331272001772	substrate binding site [chemical binding]; other site
331272001773	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
331272001774	ATP cone domain; Region: ATP-cone; pfam03477
331272001775	Class I ribonucleotide reductase; Region: RNR_I; cd01679
331272001776	active site
331272001777	dimer interface [polypeptide binding]; other site
331272001778	catalytic residues [active]
331272001779	effector binding site; other site
331272001780	R2 peptide binding site; other site
331272001781	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
331272001782	dimer interface [polypeptide binding]; other site
331272001783	putative radical transfer pathway; other site
331272001784	diiron center [ion binding]; other site
331272001785	tyrosyl radical; other site
331272001786	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
331272001787	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272001788	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
331272001789	substrate binding site [chemical binding]; other site
331272001790	ATP binding site [chemical binding]; other site
331272001791	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
331272001792	dimer interface [polypeptide binding]; other site
331272001793	catalytic triad [active]
331272001794	peroxidatic and resolving cysteines [active]
331272001795	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
331272001796	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
331272001797	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
331272001798	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
331272001799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272001800	S-adenosylmethionine binding site [chemical binding]; other site
331272001801	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
331272001802	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331272001803	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
331272001804	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
331272001805	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
331272001806	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
331272001807	carboxyltransferase (CT) interaction site; other site
331272001808	biotinylation site [posttranslational modification]; other site
331272001809	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
331272001810	Dehydroquinase class II; Region: DHquinase_II; pfam01220
331272001811	active site
331272001812	trimer interface [polypeptide binding]; other site
331272001813	dimer interface [polypeptide binding]; other site
331272001814	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
331272001815	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272001816	catalytic residues [active]
331272001817	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272001818	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272001819	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
331272001820	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
331272001821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272001822	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272001823	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
331272001824	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272001825	Exoribonuclease R [Transcription]; Region: VacB; COG0557
331272001826	RNB domain; Region: RNB; pfam00773
331272001827	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
331272001828	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
331272001829	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
331272001830	shikimate binding site; other site
331272001831	NAD(P) binding site [chemical binding]; other site
331272001832	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
331272001833	Transglycosylase; Region: Transgly; cl17702
331272001834	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
331272001835	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
331272001836	EF-hand domain pair; Region: EF_hand_5; pfam13499
331272001837	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272001838	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272001839	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272001840	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
331272001841	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
331272001842	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
331272001843	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
331272001844	active site
331272001845	intersubunit interface [polypeptide binding]; other site
331272001846	catalytic residue [active]
331272001847	short chain dehydrogenase; Provisional; Region: PRK07063
331272001848	classical (c) SDRs; Region: SDR_c; cd05233
331272001849	NAD(P) binding site [chemical binding]; other site
331272001850	active site
331272001851	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
331272001852	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
331272001853	ligand binding site [chemical binding]; other site
331272001854	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
331272001855	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272001856	Walker A/P-loop; other site
331272001857	ATP binding site [chemical binding]; other site
331272001858	Q-loop/lid; other site
331272001859	ABC transporter signature motif; other site
331272001860	Walker B; other site
331272001861	D-loop; other site
331272001862	H-loop/switch region; other site
331272001863	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272001864	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272001865	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272001866	TM-ABC transporter signature motif; other site
331272001867	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
331272001868	classical (c) SDRs; Region: SDR_c; cd05233
331272001869	NAD(P) binding site [chemical binding]; other site
331272001870	active site
331272001871	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
331272001872	active site
331272001873	catalytic residues [active]
331272001874	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
331272001875	active site
331272001876	dimer interface [polypeptide binding]; other site
331272001877	Competence-damaged protein; Region: CinA; pfam02464
331272001878	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
331272001879	tetramer interfaces [polypeptide binding]; other site
331272001880	binuclear metal-binding site [ion binding]; other site
331272001881	thiamine monophosphate kinase; Provisional; Region: PRK05731
331272001882	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
331272001883	ATP binding site [chemical binding]; other site
331272001884	dimerization interface [polypeptide binding]; other site
331272001885	malic enzyme; Reviewed; Region: PRK12862
331272001886	Malic enzyme, N-terminal domain; Region: malic; pfam00390
331272001887	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
331272001888	putative NAD(P) binding site [chemical binding]; other site
331272001889	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
331272001890	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
331272001891	active site
331272001892	barstar interaction site; other site
331272001893	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
331272001894	putative RNAase interaction site [polypeptide binding]; other site
331272001895	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
331272001896	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
331272001897	putative dimer interface [polypeptide binding]; other site
331272001898	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272001899	spermidine synthase; Provisional; Region: PRK00811
331272001900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272001901	transketolase; Reviewed; Region: PRK12753
331272001902	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
331272001903	TPP-binding site [chemical binding]; other site
331272001904	dimer interface [polypeptide binding]; other site
331272001905	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331272001906	PYR/PP interface [polypeptide binding]; other site
331272001907	dimer interface [polypeptide binding]; other site
331272001908	TPP binding site [chemical binding]; other site
331272001909	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272001910	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
331272001911	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
331272001912	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
331272001913	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272001914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272001915	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272001916	dimerization interface [polypeptide binding]; other site
331272001917	substrate binding pocket [chemical binding]; other site
331272001918	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
331272001919	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
331272001920	NADP binding site [chemical binding]; other site
331272001921	homodimer interface [polypeptide binding]; other site
331272001922	active site
331272001923	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
331272001924	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
331272001925	putative NAD(P) binding site [chemical binding]; other site
331272001926	catalytic Zn binding site [ion binding]; other site
331272001927	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272001928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272001929	putative substrate translocation pore; other site
331272001930	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
331272001931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272001932	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
331272001933	dimerization interface [polypeptide binding]; other site
331272001934	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272001935	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272001936	DNA-binding site [nucleotide binding]; DNA binding site
331272001937	FCD domain; Region: FCD; pfam07729
331272001938	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
331272001939	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272001940	allantoicase; Provisional; Region: PRK13257
331272001941	Allantoicase repeat; Region: Allantoicase; pfam03561
331272001942	Allantoicase repeat; Region: Allantoicase; pfam03561
331272001943	ureidoglycolate hydrolase; Provisional; Region: PRK13395
331272001944	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
331272001945	ferric uptake regulator; Provisional; Region: fur; PRK09462
331272001946	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
331272001947	metal binding site 2 [ion binding]; metal-binding site
331272001948	putative DNA binding helix; other site
331272001949	metal binding site 1 [ion binding]; metal-binding site
331272001950	dimer interface [polypeptide binding]; other site
331272001951	structural Zn2+ binding site [ion binding]; other site
331272001952	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
331272001953	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
331272001954	dihydrodipicolinate reductase; Provisional; Region: PRK00048
331272001955	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
331272001956	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
331272001957	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
331272001958	TolR protein; Region: tolR; TIGR02801
331272001959	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272001960	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
331272001961	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
331272001962	HIGH motif; other site
331272001963	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
331272001964	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272001965	active site
331272001966	KMSKS motif; other site
331272001967	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
331272001968	tRNA binding surface [nucleotide binding]; other site
331272001969	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331272001970	Lipopolysaccharide-assembly; Region: LptE; cl01125
331272001971	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
331272001972	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
331272001973	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
331272001974	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
331272001975	putative catalytic cysteine [active]
331272001976	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
331272001977	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272001978	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272001979	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272001980	putative active site [active]
331272001981	phosphogluconate dehydratase; Validated; Region: PRK09054
331272001982	6-phosphogluconate dehydratase; Region: edd; TIGR01196
331272001983	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
331272001984	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
331272001985	active site
331272001986	intersubunit interface [polypeptide binding]; other site
331272001987	catalytic residue [active]
331272001988	fructuronate transporter; Provisional; Region: PRK10034; cl15264
331272001989	GntP family permease; Region: GntP_permease; pfam02447
331272001990	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
331272001991	ATP-binding site [chemical binding]; other site
331272001992	Gluconate-6-phosphate binding site [chemical binding]; other site
331272001993	Shikimate kinase; Region: SKI; pfam01202
331272001994	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272001995	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
331272001996	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272001997	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272001998	adenylosuccinate lyase; Provisional; Region: PRK09285
331272001999	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
331272002000	tetramer interface [polypeptide binding]; other site
331272002001	active site
331272002002	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272002003	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002004	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272002005	dimerization interface [polypeptide binding]; other site
331272002006	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
331272002007	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
331272002008	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
331272002009	NAD(P) binding site [chemical binding]; other site
331272002010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272002011	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272002012	substrate binding pocket [chemical binding]; other site
331272002013	membrane-bound complex binding site; other site
331272002014	hinge residues; other site
331272002015	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272002016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272002017	dimer interface [polypeptide binding]; other site
331272002018	conserved gate region; other site
331272002019	putative PBP binding loops; other site
331272002020	ABC-ATPase subunit interface; other site
331272002021	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272002022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272002023	dimer interface [polypeptide binding]; other site
331272002024	conserved gate region; other site
331272002025	putative PBP binding loops; other site
331272002026	ABC-ATPase subunit interface; other site
331272002027	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272002028	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272002029	Walker A/P-loop; other site
331272002030	ATP binding site [chemical binding]; other site
331272002031	Q-loop/lid; other site
331272002032	ABC transporter signature motif; other site
331272002033	Walker B; other site
331272002034	D-loop; other site
331272002035	H-loop/switch region; other site
331272002036	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
331272002037	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
331272002038	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
331272002039	Autotransporter beta-domain; Region: Autotransporter; smart00869
331272002040	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
331272002041	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
331272002042	putative active site [active]
331272002043	putative dimer interface [polypeptide binding]; other site
331272002044	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
331272002045	active site
331272002046	substrate binding pocket [chemical binding]; other site
331272002047	dimer interface [polypeptide binding]; other site
331272002048	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
331272002049	OsmC-like protein; Region: OsmC; cl00767
331272002050	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
331272002051	23S rRNA interface [nucleotide binding]; other site
331272002052	L3 interface [polypeptide binding]; other site
331272002053	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
331272002054	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
331272002055	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
331272002056	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
331272002057	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
331272002058	active site
331272002059	HIGH motif; other site
331272002060	dimer interface [polypeptide binding]; other site
331272002061	KMSKS motif; other site
331272002062	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272002063	RNA binding surface [nucleotide binding]; other site
331272002064	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
331272002065	putative active site [active]
331272002066	dimerization interface [polypeptide binding]; other site
331272002067	putative tRNAtyr binding site [nucleotide binding]; other site
331272002068	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272002069	catalytic core [active]
331272002070	Putative ParB-like nuclease; Region: ParBc_2; cl17538
331272002071	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
331272002072	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
331272002073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272002074	Walker A motif; other site
331272002075	ATP binding site [chemical binding]; other site
331272002076	Walker B motif; other site
331272002077	arginine finger; other site
331272002078	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
331272002079	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
331272002080	RuvA N terminal domain; Region: RuvA_N; pfam01330
331272002081	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
331272002082	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
331272002083	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
331272002084	active site
331272002085	putative DNA-binding cleft [nucleotide binding]; other site
331272002086	dimer interface [polypeptide binding]; other site
331272002087	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
331272002088	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
331272002089	purine monophosphate binding site [chemical binding]; other site
331272002090	dimer interface [polypeptide binding]; other site
331272002091	putative catalytic residues [active]
331272002092	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
331272002093	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
331272002094	DNA-binding protein Fis; Provisional; Region: PRK01905
331272002095	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
331272002096	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
331272002097	FMN binding site [chemical binding]; other site
331272002098	active site
331272002099	catalytic residues [active]
331272002100	substrate binding site [chemical binding]; other site
331272002101	hypothetical protein; Provisional; Region: PRK06996
331272002102	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272002103	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
331272002104	proline aminopeptidase P II; Provisional; Region: PRK10879
331272002105	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
331272002106	active site
331272002107	putative glutathione S-transferase; Provisional; Region: PRK10357
331272002108	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
331272002109	putative C-terminal domain interface [polypeptide binding]; other site
331272002110	putative GSH binding site (G-site) [chemical binding]; other site
331272002111	putative dimer interface [polypeptide binding]; other site
331272002112	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
331272002113	dimer interface [polypeptide binding]; other site
331272002114	N-terminal domain interface [polypeptide binding]; other site
331272002115	putative substrate binding pocket (H-site) [chemical binding]; other site
331272002116	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
331272002117	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
331272002118	active site
331272002119	FMN binding site [chemical binding]; other site
331272002120	substrate binding site [chemical binding]; other site
331272002121	3Fe-4S cluster binding site [ion binding]; other site
331272002122	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
331272002123	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
331272002124	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
331272002125	nudix motif; other site
331272002126	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
331272002127	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
331272002128	ligand binding site [chemical binding]; other site
331272002129	homodimer interface [polypeptide binding]; other site
331272002130	NAD(P) binding site [chemical binding]; other site
331272002131	trimer interface B [polypeptide binding]; other site
331272002132	trimer interface A [polypeptide binding]; other site
331272002133	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
331272002134	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
331272002135	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
331272002136	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272002137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002138	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
331272002139	putative substrate binding pocket [chemical binding]; other site
331272002140	putative dimerization interface [polypeptide binding]; other site
331272002141	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
331272002142	Predicted amidohydrolase [General function prediction only]; Region: COG0388
331272002143	putative active site [active]
331272002144	catalytic triad [active]
331272002145	putative dimer interface [polypeptide binding]; other site
331272002146	Predicted transcriptional regulator [Transcription]; Region: COG2378
331272002147	HTH domain; Region: HTH_11; pfam08279
331272002148	WYL domain; Region: WYL; pfam13280
331272002149	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
331272002150	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272002151	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
331272002152	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
331272002153	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
331272002154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331272002155	Site-specific recombinase; Region: SpecificRecomb; pfam10136
331272002156	Protein of unknown function (DUF330); Region: DUF330; pfam03886
331272002157	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
331272002158	mce related protein; Region: MCE; pfam02470
331272002159	mce related protein; Region: MCE; pfam02470
331272002160	Paraquat-inducible protein A; Region: PqiA; pfam04403
331272002161	Paraquat-inducible protein A; Region: PqiA; pfam04403
331272002162	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
331272002163	YceI-like domain; Region: YceI; smart00867
331272002164	Uncharacterized conserved protein [Function unknown]; Region: COG2353
331272002165	citrate-proton symporter; Provisional; Region: PRK15075
331272002166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002167	putative substrate translocation pore; other site
331272002168	C-terminal peptidase (prc); Region: prc; TIGR00225
331272002169	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
331272002170	protein binding site [polypeptide binding]; other site
331272002171	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
331272002172	Active site serine [active]
331272002173	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
331272002174	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
331272002175	Protein export membrane protein; Region: SecD_SecF; pfam02355
331272002176	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
331272002177	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
331272002178	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
331272002179	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
331272002180	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
331272002181	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
331272002182	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
331272002183	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
331272002184	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
331272002185	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
331272002186	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
331272002187	ssDNA binding site; other site
331272002188	generic binding surface II; other site
331272002189	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272002190	ATP binding site [chemical binding]; other site
331272002191	putative Mg++ binding site [ion binding]; other site
331272002192	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272002193	nucleotide binding region [chemical binding]; other site
331272002194	ATP-binding site [chemical binding]; other site
331272002195	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272002196	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002197	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
331272002198	dimerization interface [polypeptide binding]; other site
331272002199	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
331272002200	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
331272002201	dimer interface [polypeptide binding]; other site
331272002202	active site
331272002203	heme binding site [chemical binding]; other site
331272002204	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
331272002205	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
331272002206	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
331272002207	dimerization interface [polypeptide binding]; other site
331272002208	DPS ferroxidase diiron center [ion binding]; other site
331272002209	ion pore; other site
331272002210	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
331272002211	UbiA prenyltransferase family; Region: UbiA; pfam01040
331272002212	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
331272002213	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
331272002214	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
331272002215	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272002216	catalytic residue [active]
331272002217	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
331272002218	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
331272002219	Cysteine-rich domain; Region: CCG; pfam02754
331272002220	Cysteine-rich domain; Region: CCG; pfam02754
331272002221	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
331272002222	FAD binding domain; Region: FAD_binding_4; pfam01565
331272002223	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
331272002224	FAD binding domain; Region: FAD_binding_4; pfam01565
331272002225	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272002226	FAD binding domain; Region: FAD_binding_4; pfam01565
331272002227	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
331272002228	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
331272002229	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
331272002230	heme-binding site [chemical binding]; other site
331272002231	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
331272002232	FAD binding pocket [chemical binding]; other site
331272002233	FAD binding motif [chemical binding]; other site
331272002234	phosphate binding motif [ion binding]; other site
331272002235	beta-alpha-beta structure motif; other site
331272002236	NAD binding pocket [chemical binding]; other site
331272002237	Heme binding  pocket [chemical binding]; other site
331272002238	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
331272002239	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
331272002240	protease TldD; Provisional; Region: tldD; PRK10735
331272002241	nitrilase; Region: PLN02798
331272002242	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
331272002243	putative active site [active]
331272002244	catalytic triad [active]
331272002245	dimer interface [polypeptide binding]; other site
331272002246	TIGR02099 family protein; Region: TIGR02099
331272002247	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
331272002248	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
331272002249	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
331272002250	metal binding triad; other site
331272002251	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
331272002252	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
331272002253	metal binding triad; other site
331272002254	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
331272002255	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
331272002256	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
331272002257	Walker A/P-loop; other site
331272002258	ATP binding site [chemical binding]; other site
331272002259	Q-loop/lid; other site
331272002260	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
331272002261	ABC transporter signature motif; other site
331272002262	Walker B; other site
331272002263	D-loop; other site
331272002264	H-loop/switch region; other site
331272002265	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
331272002266	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
331272002267	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
331272002268	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
331272002269	ferrochelatase; Reviewed; Region: hemH; PRK00035
331272002270	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
331272002271	C-terminal domain interface [polypeptide binding]; other site
331272002272	active site
331272002273	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
331272002274	active site
331272002275	N-terminal domain interface [polypeptide binding]; other site
331272002276	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272002277	RNA binding surface [nucleotide binding]; other site
331272002278	GrpE; Region: GrpE; pfam01025
331272002279	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
331272002280	dimer interface [polypeptide binding]; other site
331272002281	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
331272002282	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331272002283	catalytic residues [active]
331272002284	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
331272002285	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
331272002286	nucleotide binding site [chemical binding]; other site
331272002287	chaperone protein DnaJ; Provisional; Region: PRK10767
331272002288	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
331272002289	HSP70 interaction site [polypeptide binding]; other site
331272002290	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
331272002291	Zn binding sites [ion binding]; other site
331272002292	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
331272002293	dimer interface [polypeptide binding]; other site
331272002294	chorismate binding enzyme; Region: Chorismate_bind; cl10555
331272002295	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
331272002296	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
331272002297	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331272002298	homodimer interface [polypeptide binding]; other site
331272002299	substrate-cofactor binding pocket; other site
331272002300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272002301	catalytic residue [active]
331272002302	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
331272002303	oligomerization interface [polypeptide binding]; other site
331272002304	active site
331272002305	metal binding site [ion binding]; metal-binding site
331272002306	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
331272002307	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
331272002308	Substrate-binding site [chemical binding]; other site
331272002309	Substrate specificity [chemical binding]; other site
331272002310	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
331272002311	catalytic center binding site [active]
331272002312	ATP binding site [chemical binding]; other site
331272002313	poly(A) polymerase; Region: pcnB; TIGR01942
331272002314	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
331272002315	active site
331272002316	NTP binding site [chemical binding]; other site
331272002317	metal binding triad [ion binding]; metal-binding site
331272002318	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
331272002319	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
331272002320	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
331272002321	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
331272002322	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
331272002323	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
331272002324	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
331272002325	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
331272002326	dimerization interface [polypeptide binding]; other site
331272002327	putative ATP binding site [chemical binding]; other site
331272002328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002329	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272002330	putative substrate translocation pore; other site
331272002331	tetracycline repressor protein TetR; Provisional; Region: PRK13756
331272002332	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272002333	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
331272002334	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
331272002335	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
331272002336	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
331272002337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272002338	ATP binding site [chemical binding]; other site
331272002339	Mg2+ binding site [ion binding]; other site
331272002340	G-X-G motif; other site
331272002341	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
331272002342	ATP binding site [chemical binding]; other site
331272002343	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
331272002344	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
331272002345	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
331272002346	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272002347	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272002348	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272002349	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272002350	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272002351	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
331272002352	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
331272002353	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
331272002354	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272002355	polysaccharide export protein Wza; Provisional; Region: PRK15078
331272002356	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
331272002357	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
331272002358	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
331272002359	Probable Catalytic site; other site
331272002360	metal-binding site
331272002361	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272002362	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
331272002363	Probable Catalytic site; other site
331272002364	metal-binding site
331272002365	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
331272002366	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
331272002367	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272002368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272002369	binding surface
331272002370	TPR motif; other site
331272002371	TPR repeat; Region: TPR_11; pfam13414
331272002372	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272002373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272002374	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331272002375	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
331272002376	Walker A/P-loop; other site
331272002377	ATP binding site [chemical binding]; other site
331272002378	Q-loop/lid; other site
331272002379	ABC transporter signature motif; other site
331272002380	Walker B; other site
331272002381	D-loop; other site
331272002382	H-loop/switch region; other site
331272002383	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
331272002384	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
331272002385	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
331272002386	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
331272002387	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
331272002388	short chain dehydrogenase; Provisional; Region: PRK07024
331272002389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272002390	NAD(P) binding site [chemical binding]; other site
331272002391	active site
331272002392	Sulfatase; Region: Sulfatase; pfam00884
331272002393	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
331272002394	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
331272002395	active site
331272002396	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
331272002397	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
331272002398	Methyltransferase domain; Region: Methyltransf_12; pfam08242
331272002399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272002400	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
331272002401	Enoylreductase; Region: PKS_ER; smart00829
331272002402	NAD(P) binding site [chemical binding]; other site
331272002403	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
331272002404	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
331272002405	putative NADP binding site [chemical binding]; other site
331272002406	active site
331272002407	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
331272002408	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187
331272002409	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
331272002410	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
331272002411	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
331272002412	substrate-cofactor binding pocket; other site
331272002413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272002414	catalytic residue [active]
331272002415	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272002416	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
331272002417	ligand-binding site [chemical binding]; other site
331272002418	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
331272002419	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
331272002420	putative active site [active]
331272002421	putative dimer interface [polypeptide binding]; other site
331272002422	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272002423	Cupin; Region: Cupin_6; pfam12852
331272002424	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272002425	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272002426	yiaA/B two helix domain; Region: YiaAB; pfam05360
331272002427	yiaA/B two helix domain; Region: YiaAB; pfam05360
331272002428	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
331272002429	PemK-like protein; Region: PemK; pfam02452
331272002430	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
331272002431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272002432	non-specific DNA binding site [nucleotide binding]; other site
331272002433	salt bridge; other site
331272002434	sequence-specific DNA binding site [nucleotide binding]; other site
331272002435	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
331272002436	Tetratricopeptide repeat; Region: TPR_6; pfam13174
331272002437	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272002438	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272002439	ligand binding site [chemical binding]; other site
331272002440	translocation protein TolB; Provisional; Region: tolB; PRK02889
331272002441	TolB amino-terminal domain; Region: TolB_N; pfam04052
331272002442	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
331272002443	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
331272002444	TolA protein; Region: tolA_full; TIGR02794
331272002445	TonB C terminal; Region: TonB_2; pfam13103
331272002446	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272002447	TolR protein; Region: tolR; TIGR02801
331272002448	TolQ protein; Region: tolQ; TIGR02796
331272002449	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331272002450	active site
331272002451	malonic semialdehyde reductase; Provisional; Region: PRK10538
331272002452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272002453	NAD(P) binding site [chemical binding]; other site
331272002454	active site
331272002455	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
331272002456	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
331272002457	dimer interface [polypeptide binding]; other site
331272002458	active site
331272002459	glycine-pyridoxal phosphate binding site [chemical binding]; other site
331272002460	folate binding site [chemical binding]; other site
331272002461	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
331272002462	ATP cone domain; Region: ATP-cone; pfam03477
331272002463	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
331272002464	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
331272002465	Predicted membrane protein [Function unknown]; Region: COG5393
331272002466	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
331272002467	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
331272002468	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
331272002469	dimer interface [polypeptide binding]; other site
331272002470	decamer (pentamer of dimers) interface [polypeptide binding]; other site
331272002471	catalytic triad [active]
331272002472	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
331272002473	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272002474	FAD binding site [chemical binding]; other site
331272002475	substrate binding pocket [chemical binding]; other site
331272002476	catalytic base [active]
331272002477	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272002478	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272002479	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272002480	Uncharacterized conserved protein [Function unknown]; Region: COG3791
331272002481	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
331272002482	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
331272002483	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272002484	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272002485	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
331272002486	benzoate transport; Region: 2A0115; TIGR00895
331272002487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002488	putative substrate translocation pore; other site
331272002489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002490	putative substrate translocation pore; other site
331272002491	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
331272002492	fumarylacetoacetase; Region: PLN02856
331272002493	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
331272002494	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272002495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002496	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272002497	putative substrate translocation pore; other site
331272002498	MFS transport protein AraJ; Provisional; Region: PRK10091
331272002499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002500	putative substrate translocation pore; other site
331272002501	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
331272002502	putative FMN binding site [chemical binding]; other site
331272002503	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
331272002504	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
331272002505	putative ligand binding site [chemical binding]; other site
331272002506	putative NAD binding site [chemical binding]; other site
331272002507	catalytic site [active]
331272002508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002509	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272002510	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272002511	putative effector binding pocket; other site
331272002512	dimerization interface [polypeptide binding]; other site
331272002513	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
331272002514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272002515	catalytic residue [active]
331272002516	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272002517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272002518	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272002519	EamA-like transporter family; Region: EamA; pfam00892
331272002520	major facilitator superfamily transporter; Provisional; Region: PRK05122
331272002521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002522	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
331272002523	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272002524	catalytic loop [active]
331272002525	iron binding site [ion binding]; other site
331272002526	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272002527	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
331272002528	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
331272002529	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272002530	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272002531	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
331272002532	XdhC Rossmann domain; Region: XdhC_C; pfam13478
331272002533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
331272002534	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272002535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272002537	dimerization interface [polypeptide binding]; other site
331272002538	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
331272002539	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
331272002540	putative catalytic residue [active]
331272002541	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
331272002542	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
331272002543	BON domain; Region: BON; pfam04972
331272002544	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
331272002545	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
331272002546	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
331272002547	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
331272002548	active site
331272002549	NTP binding site [chemical binding]; other site
331272002550	metal binding triad [ion binding]; metal-binding site
331272002551	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
331272002552	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272002553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002554	putative substrate translocation pore; other site
331272002555	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
331272002556	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
331272002557	catalytic residues [active]
331272002558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
331272002559	YheO-like PAS domain; Region: PAS_6; pfam08348
331272002560	HTH domain; Region: HTH_22; pfam13309
331272002561	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
331272002562	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
331272002563	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272002564	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272002565	substrate binding pocket [chemical binding]; other site
331272002566	membrane-bound complex binding site; other site
331272002567	hinge residues; other site
331272002568	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272002569	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272002570	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
331272002571	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
331272002572	RNA polymerase sigma factor; Provisional; Region: PRK12511
331272002573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272002574	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
331272002575	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
331272002576	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
331272002577	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
331272002578	putative hydrophobic ligand binding site [chemical binding]; other site
331272002579	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
331272002580	oligomerisation interface [polypeptide binding]; other site
331272002581	mobile loop; other site
331272002582	roof hairpin; other site
331272002583	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331272002584	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331272002585	ring oligomerisation interface [polypeptide binding]; other site
331272002586	ATP/Mg binding site [chemical binding]; other site
331272002587	stacking interactions; other site
331272002588	hinge regions; other site
331272002589	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
331272002590	dimer interface [polypeptide binding]; other site
331272002591	substrate binding site [chemical binding]; other site
331272002592	ATP binding site [chemical binding]; other site
331272002593	Rubredoxin [Energy production and conversion]; Region: COG1773
331272002594	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
331272002595	iron binding site [ion binding]; other site
331272002596	hypothetical protein; Validated; Region: PRK00228
331272002597	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
331272002598	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272002599	active site
331272002600	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
331272002601	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
331272002602	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
331272002603	dihydroorotase; Provisional; Region: PRK07627
331272002604	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272002605	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
331272002606	active site
331272002607	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
331272002608	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331272002609	putative acyl-acceptor binding pocket; other site
331272002610	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
331272002611	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
331272002612	active site
331272002613	metal binding site [ion binding]; metal-binding site
331272002614	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
331272002615	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
331272002616	NAD binding site [chemical binding]; other site
331272002617	substrate binding site [chemical binding]; other site
331272002618	homodimer interface [polypeptide binding]; other site
331272002619	active site
331272002620	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
331272002621	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
331272002622	substrate binding site; other site
331272002623	tetramer interface; other site
331272002624	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
331272002625	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
331272002626	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
331272002627	NADP binding site [chemical binding]; other site
331272002628	active site
331272002629	putative substrate binding site [chemical binding]; other site
331272002630	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
331272002631	Ligand binding site; other site
331272002632	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
331272002633	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
331272002634	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
331272002635	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
331272002636	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
331272002637	Walker A/P-loop; other site
331272002638	ATP binding site [chemical binding]; other site
331272002639	Q-loop/lid; other site
331272002640	ABC transporter signature motif; other site
331272002641	Walker B; other site
331272002642	D-loop; other site
331272002643	H-loop/switch region; other site
331272002644	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
331272002645	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
331272002646	Probable Catalytic site; other site
331272002647	metal-binding site
331272002648	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272002649	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
331272002650	Probable Catalytic site; other site
331272002651	metal-binding site
331272002652	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
331272002653	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
331272002654	Substrate binding site; other site
331272002655	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
331272002656	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
331272002657	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
331272002658	NADP-binding site; other site
331272002659	homotetramer interface [polypeptide binding]; other site
331272002660	substrate binding site [chemical binding]; other site
331272002661	homodimer interface [polypeptide binding]; other site
331272002662	active site
331272002663	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
331272002664	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
331272002665	NADP-binding site; other site
331272002666	homotetramer interface [polypeptide binding]; other site
331272002667	substrate binding site [chemical binding]; other site
331272002668	homodimer interface [polypeptide binding]; other site
331272002669	active site
331272002670	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
331272002671	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
331272002672	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
331272002673	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
331272002674	Probable Catalytic site; other site
331272002675	metal-binding site
331272002676	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
331272002677	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
331272002678	Probable Catalytic site; other site
331272002679	metal-binding site
331272002680	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272002681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272002682	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
331272002683	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272002684	active site
331272002685	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272002686	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272002687	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
331272002688	putative NAD(P) binding site [chemical binding]; other site
331272002689	active site
331272002690	putative substrate binding site [chemical binding]; other site
331272002691	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
331272002692	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
331272002693	Mg++ binding site [ion binding]; other site
331272002694	putative catalytic motif [active]
331272002695	putative substrate binding site [chemical binding]; other site
331272002696	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
331272002697	CoA binding domain; Region: CoA_binding; cl17356
331272002698	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
331272002699	NAD(P) binding site [chemical binding]; other site
331272002700	homodimer interface [polypeptide binding]; other site
331272002701	substrate binding site [chemical binding]; other site
331272002702	active site
331272002703	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
331272002704	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
331272002705	Mg++ binding site [ion binding]; other site
331272002706	putative catalytic motif [active]
331272002707	UDP-glucose 4-epimerase; Region: PLN02240
331272002708	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
331272002709	NAD binding site [chemical binding]; other site
331272002710	homodimer interface [polypeptide binding]; other site
331272002711	active site
331272002712	substrate binding site [chemical binding]; other site
331272002713	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
331272002714	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272002715	putative ADP-binding pocket [chemical binding]; other site
331272002716	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272002717	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272002718	active site
331272002719	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
331272002720	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
331272002721	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
331272002722	active site
331272002723	substrate binding site [chemical binding]; other site
331272002724	metal binding site [ion binding]; metal-binding site
331272002725	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272002726	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272002727	putative active site [active]
331272002728	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
331272002729	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
331272002730	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
331272002731	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272002732	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331272002733	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
331272002734	UreF; Region: UreF; pfam01730
331272002735	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
331272002736	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
331272002737	dimer interface [polypeptide binding]; other site
331272002738	catalytic residues [active]
331272002739	urease subunit alpha; Reviewed; Region: ureC; PRK13207
331272002740	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
331272002741	subunit interactions [polypeptide binding]; other site
331272002742	active site
331272002743	flap region; other site
331272002744	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
331272002745	gamma-beta subunit interface [polypeptide binding]; other site
331272002746	alpha-beta subunit interface [polypeptide binding]; other site
331272002747	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
331272002748	alpha-gamma subunit interface [polypeptide binding]; other site
331272002749	beta-gamma subunit interface [polypeptide binding]; other site
331272002750	UreD urease accessory protein; Region: UreD; cl00530
331272002751	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
331272002752	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
331272002753	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
331272002754	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
331272002755	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272002756	Walker A/P-loop; other site
331272002757	ATP binding site [chemical binding]; other site
331272002758	Q-loop/lid; other site
331272002759	ABC transporter signature motif; other site
331272002760	Walker B; other site
331272002761	D-loop; other site
331272002762	H-loop/switch region; other site
331272002763	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
331272002764	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272002765	Walker A/P-loop; other site
331272002766	ATP binding site [chemical binding]; other site
331272002767	Q-loop/lid; other site
331272002768	ABC transporter signature motif; other site
331272002769	Walker B; other site
331272002770	D-loop; other site
331272002771	H-loop/switch region; other site
331272002772	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272002773	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272002774	TM-ABC transporter signature motif; other site
331272002775	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272002776	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272002777	TM-ABC transporter signature motif; other site
331272002778	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
331272002779	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
331272002780	putative ligand binding site [chemical binding]; other site
331272002781	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
331272002782	active site residue [active]
331272002783	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
331272002784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272002785	S-adenosylmethionine binding site [chemical binding]; other site
331272002786	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
331272002787	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272002788	FeS/SAM binding site; other site
331272002789	HemN C-terminal domain; Region: HemN_C; pfam06969
331272002790	Flagellin N-methylase; Region: FliB; pfam03692
331272002791	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
331272002792	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
331272002793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272002794	S-adenosylmethionine binding site [chemical binding]; other site
331272002795	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331272002796	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272002797	P-loop; other site
331272002798	Magnesium ion binding site [ion binding]; other site
331272002799	L-asparaginase II; Region: Asparaginase_II; cl01842
331272002800	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272002801	Magnesium ion binding site [ion binding]; other site
331272002802	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272002803	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272002804	non-specific DNA binding site [nucleotide binding]; other site
331272002805	salt bridge; other site
331272002806	sequence-specific DNA binding site [nucleotide binding]; other site
331272002807	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331272002808	active site
331272002809	catalytic residues [active]
331272002810	DNA binding site [nucleotide binding]
331272002811	Int/Topo IB signature motif; other site
331272002812	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
331272002813	polymerase nucleotide-binding site; other site
331272002814	DNA-binding residues [nucleotide binding]; DNA binding site
331272002815	nucleotide binding site [chemical binding]; other site
331272002816	primase nucleotide-binding site [nucleotide binding]; other site
331272002817	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
331272002818	hypothetical protein; Provisional; Region: PRK14709
331272002819	D5 N terminal like; Region: D5_N; smart00885
331272002820	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
331272002821	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
331272002822	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
331272002823	putative active site pocket [active]
331272002824	metal binding site [ion binding]; metal-binding site
331272002825	LysE type translocator; Region: LysE; cl00565
331272002826	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
331272002827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272002828	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
331272002829	putative dimerization interface [polypeptide binding]; other site
331272002830	benzoate transport; Region: 2A0115; TIGR00895
331272002831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002832	putative substrate translocation pore; other site
331272002833	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272002834	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272002835	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
331272002836	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272002837	substrate binding site [chemical binding]; other site
331272002838	oxyanion hole (OAH) forming residues; other site
331272002839	trimer interface [polypeptide binding]; other site
331272002840	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
331272002841	Chromate transporter; Region: Chromate_transp; pfam02417
331272002842	Chromate transporter; Region: Chromate_transp; pfam02417
331272002843	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
331272002844	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272002845	DNA-binding site [nucleotide binding]; DNA binding site
331272002846	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
331272002847	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
331272002848	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
331272002849	dimer interface [polypeptide binding]; other site
331272002850	ADP-ribose binding site [chemical binding]; other site
331272002851	active site
331272002852	nudix motif; other site
331272002853	metal binding site [ion binding]; metal-binding site
331272002854	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
331272002855	NAD-dependent deacetylase; Provisional; Region: PRK00481
331272002856	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
331272002857	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272002858	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
331272002859	active site
331272002860	catalytic triad [active]
331272002861	calcium binding site [ion binding]; other site
331272002862	chromosome condensation membrane protein; Provisional; Region: PRK14196
331272002863	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
331272002864	YGGT family; Region: YGGT; pfam02325
331272002865	YGGT family; Region: YGGT; pfam02325
331272002866	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
331272002867	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
331272002868	LysE type translocator; Region: LysE; cl00565
331272002869	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
331272002870	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272002871	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272002872	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272002873	catalytic residue [active]
331272002874	aminotransferase; Validated; Region: PRK07337
331272002875	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272002876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272002877	homodimer interface [polypeptide binding]; other site
331272002878	catalytic residue [active]
331272002879	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
331272002880	putative RNA binding site [nucleotide binding]; other site
331272002881	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
331272002882	homopentamer interface [polypeptide binding]; other site
331272002883	active site
331272002884	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
331272002885	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
331272002886	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
331272002887	dimerization interface [polypeptide binding]; other site
331272002888	active site
331272002889	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
331272002890	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
331272002891	Lumazine binding domain; Region: Lum_binding; pfam00677
331272002892	Lumazine binding domain; Region: Lum_binding; pfam00677
331272002893	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
331272002894	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
331272002895	catalytic motif [active]
331272002896	Zn binding site [ion binding]; other site
331272002897	RibD C-terminal domain; Region: RibD_C; cl17279
331272002898	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
331272002899	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272002900	inhibitor-cofactor binding pocket; inhibition site
331272002901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272002902	catalytic residue [active]
331272002903	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
331272002904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002905	putative substrate translocation pore; other site
331272002906	bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101
331272002907	glucokinase; Provisional; Region: glk; PRK00292
331272002908	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272002909	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272002910	putative active site [active]
331272002911	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
331272002912	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
331272002913	putative active site [active]
331272002914	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
331272002915	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
331272002916	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
331272002917	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272002918	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272002919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272002920	dimer interface [polypeptide binding]; other site
331272002921	conserved gate region; other site
331272002922	putative PBP binding loops; other site
331272002923	ABC-ATPase subunit interface; other site
331272002924	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272002925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272002926	dimer interface [polypeptide binding]; other site
331272002927	conserved gate region; other site
331272002928	putative PBP binding loops; other site
331272002929	ABC-ATPase subunit interface; other site
331272002930	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
331272002931	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272002932	Walker A/P-loop; other site
331272002933	ATP binding site [chemical binding]; other site
331272002934	Q-loop/lid; other site
331272002935	ABC transporter signature motif; other site
331272002936	Walker B; other site
331272002937	D-loop; other site
331272002938	H-loop/switch region; other site
331272002939	TOBE domain; Region: TOBE_2; pfam08402
331272002940	Predicted membrane protein [Function unknown]; Region: COG2860
331272002941	UPF0126 domain; Region: UPF0126; pfam03458
331272002942	UPF0126 domain; Region: UPF0126; pfam03458
331272002943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
331272002944	Smr domain; Region: Smr; pfam01713
331272002945	thioredoxin reductase; Provisional; Region: PRK10262
331272002946	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272002947	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272002948	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
331272002949	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
331272002950	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
331272002951	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
331272002952	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
331272002953	recombination factor protein RarA; Reviewed; Region: PRK13342
331272002954	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272002955	Walker A motif; other site
331272002956	ATP binding site [chemical binding]; other site
331272002957	Walker B motif; other site
331272002958	arginine finger; other site
331272002959	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
331272002960	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
331272002961	seryl-tRNA synthetase; Provisional; Region: PRK05431
331272002962	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
331272002963	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
331272002964	dimer interface [polypeptide binding]; other site
331272002965	active site
331272002966	motif 1; other site
331272002967	motif 2; other site
331272002968	motif 3; other site
331272002969	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
331272002970	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272002971	Di-iron ligands [ion binding]; other site
331272002972	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272002973	septum formation inhibitor; Reviewed; Region: PRK01973
331272002974	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
331272002975	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
331272002976	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
331272002977	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
331272002978	Switch I; other site
331272002979	Switch II; other site
331272002980	cell division topological specificity factor MinE; Provisional; Region: PRK13989
331272002981	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
331272002982	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
331272002983	putative ion selectivity filter; other site
331272002984	putative pore gating glutamate residue; other site
331272002985	putative H+/Cl- coupling transport residue; other site
331272002986	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272002987	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272002988	putative active site [active]
331272002989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272002990	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272002991	putative substrate translocation pore; other site
331272002992	Gram-negative bacterial tonB protein; Region: TonB; cl10048
331272002993	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
331272002994	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272002995	FeS/SAM binding site; other site
331272002996	HemN C-terminal domain; Region: HemN_C; pfam06969
331272002997	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
331272002998	active site
331272002999	dimerization interface [polypeptide binding]; other site
331272003000	ribonuclease PH; Reviewed; Region: rph; PRK00173
331272003001	Ribonuclease PH; Region: RNase_PH_bact; cd11362
331272003002	hexamer interface [polypeptide binding]; other site
331272003003	active site
331272003004	hypothetical protein; Provisional; Region: PRK11820
331272003005	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
331272003006	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
331272003007	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
331272003008	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
331272003009	catalytic site [active]
331272003010	G-X2-G-X-G-K; other site
331272003011	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
331272003012	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
331272003013	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272003014	Zn2+ binding site [ion binding]; other site
331272003015	Mg2+ binding site [ion binding]; other site
331272003016	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
331272003017	synthetase active site [active]
331272003018	NTP binding site [chemical binding]; other site
331272003019	metal binding site [ion binding]; metal-binding site
331272003020	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
331272003021	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
331272003022	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
331272003023	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
331272003024	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
331272003025	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272003026	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272003027	trimer interface [polypeptide binding]; other site
331272003028	eyelet of channel; other site
331272003029	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272003030	DNA-binding site [nucleotide binding]; DNA binding site
331272003031	RNA-binding motif; other site
331272003032	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331272003033	active site
331272003034	catalytic site [active]
331272003035	substrate binding site [chemical binding]; other site
331272003036	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
331272003037	GIY-YIG motif/motif A; other site
331272003038	active site
331272003039	catalytic site [active]
331272003040	putative DNA binding site [nucleotide binding]; other site
331272003041	metal binding site [ion binding]; metal-binding site
331272003042	chorismate mutase; Provisional; Region: PRK09269
331272003043	Chorismate mutase type II; Region: CM_2; cl00693
331272003044	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
331272003045	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
331272003046	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272003047	N-terminal plug; other site
331272003048	ligand-binding site [chemical binding]; other site
331272003049	fructose-1,6-bisphosphatase family protein; Region: PLN02628
331272003050	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
331272003051	AMP binding site [chemical binding]; other site
331272003052	metal binding site [ion binding]; metal-binding site
331272003053	active site
331272003054	aminopeptidase N; Provisional; Region: pepN; PRK14015
331272003055	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
331272003056	active site
331272003057	Zn binding site [ion binding]; other site
331272003058	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
331272003059	Predicted membrane protein [Function unknown]; Region: COG2119
331272003060	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
331272003061	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
331272003062	guanine deaminase; Provisional; Region: PRK09228
331272003063	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
331272003064	active site
331272003065	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
331272003066	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
331272003067	XdhC Rossmann domain; Region: XdhC_C; pfam13478
331272003068	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
331272003069	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
331272003070	active site
331272003071	purine riboside binding site [chemical binding]; other site
331272003072	disulfide bond formation protein B; Provisional; Region: PRK02110
331272003073	amidase; Provisional; Region: PRK07056
331272003074	Amidase; Region: Amidase; cl11426
331272003075	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272003076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272003077	DNA-binding site [nucleotide binding]; DNA binding site
331272003078	FCD domain; Region: FCD; pfam07729
331272003079	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
331272003080	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
331272003081	catalytic triad [active]
331272003082	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
331272003083	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
331272003084	citrate-proton symporter; Provisional; Region: PRK15075
331272003085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003086	putative substrate translocation pore; other site
331272003087	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
331272003088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272003089	binding surface
331272003090	TPR motif; other site
331272003091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272003092	binding surface
331272003093	TPR motif; other site
331272003094	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272003095	hypothetical protein; Provisional; Region: PRK06184
331272003096	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272003097	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
331272003098	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
331272003099	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272003100	catalytic loop [active]
331272003101	iron binding site [ion binding]; other site
331272003102	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
331272003103	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
331272003104	[4Fe-4S] binding site [ion binding]; other site
331272003105	molybdopterin cofactor binding site; other site
331272003106	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
331272003107	molybdopterin cofactor binding site; other site
331272003108	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
331272003109	putative dimer interface [polypeptide binding]; other site
331272003110	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
331272003111	SLBB domain; Region: SLBB; pfam10531
331272003112	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
331272003113	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
331272003114	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
331272003115	putative dimer interface [polypeptide binding]; other site
331272003116	[2Fe-2S] cluster binding site [ion binding]; other site
331272003117	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
331272003118	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
331272003119	PBP superfamily domain; Region: PBP_like; pfam12727
331272003120	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272003121	phosphoglycolate phosphatase; Provisional; Region: PRK13222
331272003122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272003123	motif II; other site
331272003124	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
331272003125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272003126	S-adenosylmethionine binding site [chemical binding]; other site
331272003127	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272003128	ligand binding site [chemical binding]; other site
331272003129	DNA gyrase subunit A; Validated; Region: PRK05560
331272003130	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
331272003131	CAP-like domain; other site
331272003132	active site
331272003133	primary dimer interface [polypeptide binding]; other site
331272003134	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003135	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003136	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003137	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003138	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003139	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272003140	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
331272003141	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
331272003142	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
331272003143	homodimer interface [polypeptide binding]; other site
331272003144	substrate-cofactor binding pocket; other site
331272003145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272003146	catalytic residue [active]
331272003147	Chorismate mutase type II; Region: CM_2; cl00693
331272003148	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
331272003149	Prephenate dehydratase; Region: PDT; pfam00800
331272003150	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
331272003151	putative L-Phe binding site [chemical binding]; other site
331272003152	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
331272003153	prephenate dehydrogenase; Validated; Region: PRK08507
331272003154	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
331272003155	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
331272003156	hinge; other site
331272003157	active site
331272003158	cytidylate kinase; Provisional; Region: cmk; PRK00023
331272003159	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
331272003160	CMP-binding site; other site
331272003161	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
331272003162	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
331272003163	RNA binding site [nucleotide binding]; other site
331272003164	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
331272003165	RNA binding site [nucleotide binding]; other site
331272003166	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
331272003167	RNA binding site [nucleotide binding]; other site
331272003168	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
331272003169	RNA binding site [nucleotide binding]; other site
331272003170	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
331272003171	RNA binding site [nucleotide binding]; other site
331272003172	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
331272003173	RNA binding site [nucleotide binding]; other site
331272003174	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
331272003175	IHF dimer interface [polypeptide binding]; other site
331272003176	IHF - DNA interface [nucleotide binding]; other site
331272003177	tetratricopeptide repeat protein; Provisional; Region: PRK11788
331272003178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272003179	binding surface
331272003180	TPR motif; other site
331272003181	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
331272003182	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331272003183	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
331272003184	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
331272003185	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
331272003186	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272003187	putative ribose interaction site [chemical binding]; other site
331272003188	putative ADP binding site [chemical binding]; other site
331272003189	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
331272003190	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
331272003191	NADP binding site [chemical binding]; other site
331272003192	homopentamer interface [polypeptide binding]; other site
331272003193	substrate binding site [chemical binding]; other site
331272003194	active site
331272003195	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
331272003196	cysteine synthase B; Region: cysM; TIGR01138
331272003197	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
331272003198	dimer interface [polypeptide binding]; other site
331272003199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272003200	catalytic residue [active]
331272003201	Transglycosylase SLT domain; Region: SLT_2; pfam13406
331272003202	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272003203	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272003204	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
331272003205	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
331272003206	putative active site [active]
331272003207	Zn binding site [ion binding]; other site
331272003208	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
331272003209	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272003210	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
331272003211	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
331272003212	Walker A/P-loop; other site
331272003213	ATP binding site [chemical binding]; other site
331272003214	Q-loop/lid; other site
331272003215	ABC transporter signature motif; other site
331272003216	Walker B; other site
331272003217	D-loop; other site
331272003218	H-loop/switch region; other site
331272003219	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
331272003220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003221	dimer interface [polypeptide binding]; other site
331272003222	conserved gate region; other site
331272003223	ABC-ATPase subunit interface; other site
331272003224	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
331272003225	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
331272003226	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
331272003227	Ligand binding site [chemical binding]; other site
331272003228	Electron transfer flavoprotein domain; Region: ETF; pfam01012
331272003229	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
331272003230	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
331272003231	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
331272003232	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
331272003233	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272003234	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272003235	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272003236	AsnC family; Region: AsnC_trans_reg; pfam01037
331272003237	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
331272003238	TM2 domain; Region: TM2; pfam05154
331272003239	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
331272003240	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
331272003241	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
331272003242	RimM N-terminal domain; Region: RimM; pfam01782
331272003243	PRC-barrel domain; Region: PRC; pfam05239
331272003244	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
331272003245	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
331272003246	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
331272003247	putative active site [active]
331272003248	putative CoA binding site [chemical binding]; other site
331272003249	nudix motif; other site
331272003250	metal binding site [ion binding]; metal-binding site
331272003251	CobD/CbiB family protein; Provisional; Region: PRK07630
331272003252	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
331272003253	GTPase RsgA; Reviewed; Region: PRK00098
331272003254	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
331272003255	RNA binding site [nucleotide binding]; other site
331272003256	homodimer interface [polypeptide binding]; other site
331272003257	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
331272003258	GTPase/Zn-binding domain interface [polypeptide binding]; other site
331272003259	GTP/Mg2+ binding site [chemical binding]; other site
331272003260	G4 box; other site
331272003261	G5 box; other site
331272003262	G1 box; other site
331272003263	Switch I region; other site
331272003264	G2 box; other site
331272003265	G3 box; other site
331272003266	Switch II region; other site
331272003267	Peptidase family M48; Region: Peptidase_M48; pfam01435
331272003268	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
331272003269	catalytic site [active]
331272003270	putative active site [active]
331272003271	putative substrate binding site [chemical binding]; other site
331272003272	dimer interface [polypeptide binding]; other site
331272003273	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
331272003274	MPT binding site; other site
331272003275	trimer interface [polypeptide binding]; other site
331272003276	hypothetical protein; Provisional; Region: PRK05255
331272003277	peptidase PmbA; Provisional; Region: PRK11040
331272003278	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
331272003279	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
331272003280	folate binding site [chemical binding]; other site
331272003281	NADP+ binding site [chemical binding]; other site
331272003282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272003283	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
331272003284	Walker A motif; other site
331272003285	ATP binding site [chemical binding]; other site
331272003286	Walker B motif; other site
331272003287	arginine finger; other site
331272003288	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
331272003289	thymidylate synthase; Provisional; Region: thyA; PRK13821
331272003290	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
331272003291	dimerization interface [polypeptide binding]; other site
331272003292	active site
331272003293	FecR protein; Region: FecR; pfam04773
331272003294	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272003295	dimerization interface [polypeptide binding]; other site
331272003296	putative DNA binding site [nucleotide binding]; other site
331272003297	putative Zn2+ binding site [ion binding]; other site
331272003298	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
331272003299	fumarate hydratase; Reviewed; Region: fumC; PRK00485
331272003300	Class II fumarases; Region: Fumarase_classII; cd01362
331272003301	active site
331272003302	tetramer interface [polypeptide binding]; other site
331272003303	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
331272003304	putative efflux protein, MATE family; Region: matE; TIGR00797
331272003305	cation binding site [ion binding]; other site
331272003306	S4 domain; Region: S4_2; pfam13275
331272003307	Protein of unknown function (DUF4088); Region: DUF4088; pfam13317
331272003308	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
331272003309	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
331272003310	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272003311	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272003312	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272003313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272003314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
331272003315	CreA protein; Region: CreA; pfam05981
331272003316	Ferredoxin [Energy production and conversion]; Region: COG1146
331272003317	4Fe-4S binding domain; Region: Fer4; cl02805
331272003318	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
331272003319	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
331272003320	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
331272003321	active site
331272003322	Uncharacterized conserved protein [Function unknown]; Region: COG1556
331272003323	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
331272003324	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
331272003325	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
331272003326	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
331272003327	dimerization interface [polypeptide binding]; other site
331272003328	ligand binding site [chemical binding]; other site
331272003329	NADP binding site [chemical binding]; other site
331272003330	catalytic site [active]
331272003331	RmuC family; Region: RmuC; pfam02646
331272003332	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272003333	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272003334	Coenzyme A binding pocket [chemical binding]; other site
331272003335	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
331272003336	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
331272003337	dimer interface [polypeptide binding]; other site
331272003338	putative functional site; other site
331272003339	putative MPT binding site; other site
331272003340	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
331272003341	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
331272003342	GTP binding site; other site
331272003343	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
331272003344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272003345	FeS/SAM binding site; other site
331272003346	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
331272003347	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
331272003348	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
331272003349	homodimer interface [polypeptide binding]; other site
331272003350	oligonucleotide binding site [chemical binding]; other site
331272003351	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
331272003352	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
331272003353	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331272003354	active site
331272003355	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
331272003356	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272003357	motif II; other site
331272003358	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
331272003359	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
331272003360	iron-sulfur cluster [ion binding]; other site
331272003361	[2Fe-2S] cluster binding site [ion binding]; other site
331272003362	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
331272003363	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
331272003364	tandem repeat interface [polypeptide binding]; other site
331272003365	oligomer interface [polypeptide binding]; other site
331272003366	active site residues [active]
331272003367	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
331272003368	putative SAM binding site [chemical binding]; other site
331272003369	homodimer interface [polypeptide binding]; other site
331272003370	Maf-like protein; Region: Maf; pfam02545
331272003371	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
331272003372	active site
331272003373	dimer interface [polypeptide binding]; other site
331272003374	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
331272003375	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
331272003376	putative phosphate acyltransferase; Provisional; Region: PRK05331
331272003377	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
331272003378	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
331272003379	dimer interface [polypeptide binding]; other site
331272003380	active site
331272003381	CoA binding pocket [chemical binding]; other site
331272003382	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
331272003383	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
331272003384	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
331272003385	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
331272003386	NAD(P) binding site [chemical binding]; other site
331272003387	homotetramer interface [polypeptide binding]; other site
331272003388	homodimer interface [polypeptide binding]; other site
331272003389	active site
331272003390	acyl carrier protein; Provisional; Region: acpP; PRK00982
331272003391	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
331272003392	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
331272003393	dimer interface [polypeptide binding]; other site
331272003394	active site
331272003395	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
331272003396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272003397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272003398	DNA binding residues [nucleotide binding]
331272003399	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
331272003400	anti-sigma E factor; Provisional; Region: rseB; PRK09455
331272003401	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
331272003402	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
331272003403	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331272003404	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272003405	protein binding site [polypeptide binding]; other site
331272003406	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272003407	protein binding site [polypeptide binding]; other site
331272003408	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
331272003409	GTP-binding protein LepA; Provisional; Region: PRK05433
331272003410	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
331272003411	G1 box; other site
331272003412	putative GEF interaction site [polypeptide binding]; other site
331272003413	GTP/Mg2+ binding site [chemical binding]; other site
331272003414	Switch I region; other site
331272003415	G2 box; other site
331272003416	G3 box; other site
331272003417	Switch II region; other site
331272003418	G4 box; other site
331272003419	G5 box; other site
331272003420	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
331272003421	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
331272003422	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
331272003423	signal peptidase I; Provisional; Region: PRK10861
331272003424	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
331272003425	Catalytic site [active]
331272003426	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
331272003427	ribonuclease III; Reviewed; Region: PRK12372
331272003428	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
331272003429	dimerization interface [polypeptide binding]; other site
331272003430	active site
331272003431	metal binding site [ion binding]; metal-binding site
331272003432	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
331272003433	GTPase Era; Reviewed; Region: era; PRK00089
331272003434	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
331272003435	G1 box; other site
331272003436	GTP/Mg2+ binding site [chemical binding]; other site
331272003437	Switch I region; other site
331272003438	G2 box; other site
331272003439	Switch II region; other site
331272003440	G3 box; other site
331272003441	G4 box; other site
331272003442	G5 box; other site
331272003443	KH domain; Region: KH_2; pfam07650
331272003444	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
331272003445	Recombination protein O N terminal; Region: RecO_N; pfam11967
331272003446	Recombination protein O C terminal; Region: RecO_C; pfam02565
331272003447	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
331272003448	active site
331272003449	hydrophilic channel; other site
331272003450	dimerization interface [polypeptide binding]; other site
331272003451	catalytic residues [active]
331272003452	active site lid [active]
331272003453	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
331272003454	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
331272003455	beta-hexosaminidase; Provisional; Region: PRK05337
331272003456	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272003457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272003458	active site
331272003459	phosphorylation site [posttranslational modification]
331272003460	intermolecular recognition site; other site
331272003461	dimerization interface [polypeptide binding]; other site
331272003462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272003463	Walker A motif; other site
331272003464	ATP binding site [chemical binding]; other site
331272003465	Walker B motif; other site
331272003466	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272003467	elongation factor P; Validated; Region: PRK00529
331272003468	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
331272003469	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
331272003470	RNA binding site [nucleotide binding]; other site
331272003471	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
331272003472	RNA binding site [nucleotide binding]; other site
331272003473	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
331272003474	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
331272003475	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
331272003476	GIY-YIG motif/motif A; other site
331272003477	active site
331272003478	catalytic site [active]
331272003479	putative DNA binding site [nucleotide binding]; other site
331272003480	metal binding site [ion binding]; metal-binding site
331272003481	UvrB/uvrC motif; Region: UVR; pfam02151
331272003482	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
331272003483	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
331272003484	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272003485	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
331272003486	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272003487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272003488	non-specific DNA binding site [nucleotide binding]; other site
331272003489	salt bridge; other site
331272003490	sequence-specific DNA binding site [nucleotide binding]; other site
331272003491	Cupin domain; Region: Cupin_2; cl17218
331272003492	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
331272003493	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
331272003494	active site
331272003495	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
331272003496	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272003497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003498	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
331272003499	putative effector binding pocket; other site
331272003500	putative dimerization interface [polypeptide binding]; other site
331272003501	Pirin-related protein [General function prediction only]; Region: COG1741
331272003502	Pirin; Region: Pirin; pfam02678
331272003503	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
331272003504	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
331272003505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272003506	Coenzyme A binding pocket [chemical binding]; other site
331272003507	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
331272003508	Protein of unknown function (DUF461); Region: DUF461; pfam04314
331272003509	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
331272003510	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
331272003511	Cu(I) binding site [ion binding]; other site
331272003512	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
331272003513	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
331272003514	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
331272003515	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
331272003516	active site
331272003517	homotetramer interface [polypeptide binding]; other site
331272003518	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331272003519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272003520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272003521	Walker A/P-loop; other site
331272003522	ATP binding site [chemical binding]; other site
331272003523	Q-loop/lid; other site
331272003524	ABC transporter signature motif; other site
331272003525	Walker B; other site
331272003526	D-loop; other site
331272003527	H-loop/switch region; other site
331272003528	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272003529	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
331272003530	putative ADP-binding pocket [chemical binding]; other site
331272003531	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
331272003532	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
331272003533	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
331272003534	active site
331272003535	tetramer interface [polypeptide binding]; other site
331272003536	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272003537	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
331272003538	DNA-binding site [nucleotide binding]; DNA binding site
331272003539	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272003540	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272003541	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272003542	dimerization interface [polypeptide binding]; other site
331272003543	ligand binding site [chemical binding]; other site
331272003544	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
331272003545	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272003546	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272003547	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272003548	pyridoxamine kinase; Validated; Region: PRK05756
331272003549	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
331272003550	dimer interface [polypeptide binding]; other site
331272003551	pyridoxal binding site [chemical binding]; other site
331272003552	ATP binding site [chemical binding]; other site
331272003553	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272003554	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272003555	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
331272003556	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272003557	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
331272003558	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
331272003559	ligand binding site; other site
331272003560	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
331272003561	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
331272003562	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
331272003563	B12 binding site [chemical binding]; other site
331272003564	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272003565	FeS/SAM binding site; other site
331272003566	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
331272003567	putative active site [active]
331272003568	YdjC motif; other site
331272003569	Mg binding site [ion binding]; other site
331272003570	putative homodimer interface [polypeptide binding]; other site
331272003571	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
331272003572	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
331272003573	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272003574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003575	dimer interface [polypeptide binding]; other site
331272003576	conserved gate region; other site
331272003577	putative PBP binding loops; other site
331272003578	ABC-ATPase subunit interface; other site
331272003579	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272003580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003581	dimer interface [polypeptide binding]; other site
331272003582	conserved gate region; other site
331272003583	putative PBP binding loops; other site
331272003584	ABC-ATPase subunit interface; other site
331272003585	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
331272003586	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272003587	Walker A/P-loop; other site
331272003588	ATP binding site [chemical binding]; other site
331272003589	Q-loop/lid; other site
331272003590	ABC transporter signature motif; other site
331272003591	Walker B; other site
331272003592	D-loop; other site
331272003593	H-loop/switch region; other site
331272003594	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272003595	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
331272003596	conserved cys residue [active]
331272003597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272003598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272003599	Transposase, Mutator family; Region: Transposase_mut; pfam00872
331272003600	MULE transposase domain; Region: MULE; pfam10551
331272003601	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
331272003602	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272003603	inhibitor-cofactor binding pocket; inhibition site
331272003604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272003605	catalytic residue [active]
331272003606	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
331272003607	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
331272003608	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
331272003609	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
331272003610	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
331272003611	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
331272003612	NAD(P) binding site [chemical binding]; other site
331272003613	catalytic residues [active]
331272003614	succinylarginine dihydrolase; Provisional; Region: PRK13281
331272003615	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
331272003616	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
331272003617	putative active site [active]
331272003618	Zn binding site [ion binding]; other site
331272003619	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272003620	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272003621	substrate binding pocket [chemical binding]; other site
331272003622	membrane-bound complex binding site; other site
331272003623	hinge residues; other site
331272003624	HDOD domain; Region: HDOD; pfam08668
331272003625	PAS domain; Region: PAS_9; pfam13426
331272003626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272003627	putative active site [active]
331272003628	heme pocket [chemical binding]; other site
331272003629	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272003630	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272003631	metal binding site [ion binding]; metal-binding site
331272003632	active site
331272003633	I-site; other site
331272003634	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272003635	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
331272003636	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272003637	catalytic triad [active]
331272003638	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
331272003639	NADH(P)-binding; Region: NAD_binding_10; pfam13460
331272003640	NAD(P) binding site [chemical binding]; other site
331272003641	putative active site [active]
331272003642	Probable transposase; Region: OrfB_IS605; pfam01385
331272003643	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272003644	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272003645	NYN domain; Region: NYN; pfam01936
331272003646	putative metal binding site [ion binding]; other site
331272003647	Uncharacterized conserved protein [Function unknown]; Region: COG1432
331272003648	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
331272003649	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331272003650	active site
331272003651	metal binding site [ion binding]; metal-binding site
331272003652	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272003653	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272003654	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
331272003655	Protein export membrane protein; Region: SecD_SecF; cl14618
331272003656	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
331272003657	Protein export membrane protein; Region: SecD_SecF; cl14618
331272003658	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272003659	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272003660	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272003661	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272003662	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272003663	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272003664	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
331272003665	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
331272003666	Predicted transcriptional regulator [Transcription]; Region: COG1959
331272003667	Transcriptional regulator; Region: Rrf2; pfam02082
331272003668	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
331272003669	NADH(P)-binding; Region: NAD_binding_10; pfam13460
331272003670	NAD binding site [chemical binding]; other site
331272003671	putative active site [active]
331272003672	substrate binding site [chemical binding]; other site
331272003673	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272003674	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272003675	putative DNA binding site [nucleotide binding]; other site
331272003676	putative Zn2+ binding site [ion binding]; other site
331272003677	AsnC family; Region: AsnC_trans_reg; pfam01037
331272003678	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
331272003679	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
331272003680	Walker A/P-loop; other site
331272003681	ATP binding site [chemical binding]; other site
331272003682	Q-loop/lid; other site
331272003683	ABC transporter signature motif; other site
331272003684	Walker B; other site
331272003685	D-loop; other site
331272003686	H-loop/switch region; other site
331272003687	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
331272003688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003689	dimer interface [polypeptide binding]; other site
331272003690	conserved gate region; other site
331272003691	putative PBP binding loops; other site
331272003692	ABC-ATPase subunit interface; other site
331272003693	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
331272003694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003695	dimer interface [polypeptide binding]; other site
331272003696	conserved gate region; other site
331272003697	putative PBP binding loops; other site
331272003698	ABC-ATPase subunit interface; other site
331272003699	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272003700	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272003701	putative proline-specific permease; Provisional; Region: proY; PRK10580
331272003702	Spore germination protein; Region: Spore_permease; cl17796
331272003703	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
331272003704	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
331272003705	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272003706	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
331272003707	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
331272003708	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
331272003709	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
331272003710	Family description; Region: UvrD_C_2; pfam13538
331272003711	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
331272003712	AAA domain; Region: AAA_30; pfam13604
331272003713	Family description; Region: UvrD_C_2; pfam13538
331272003714	hypothetical protein; Provisional; Region: PRK09256
331272003715	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
331272003716	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272003717	EamA-like transporter family; Region: EamA; pfam00892
331272003718	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272003719	EamA-like transporter family; Region: EamA; pfam00892
331272003720	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
331272003721	ThiC-associated domain; Region: ThiC-associated; pfam13667
331272003722	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
331272003723	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
331272003724	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
331272003725	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
331272003726	Moco binding site; other site
331272003727	metal coordination site [ion binding]; other site
331272003728	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272003729	non-specific DNA binding site [nucleotide binding]; other site
331272003730	salt bridge; other site
331272003731	sequence-specific DNA binding site [nucleotide binding]; other site
331272003732	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
331272003733	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
331272003734	EamA-like transporter family; Region: EamA; pfam00892
331272003735	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272003736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003737	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
331272003738	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272003739	active site
331272003740	metal binding site [ion binding]; metal-binding site
331272003741	hexamer interface [polypeptide binding]; other site
331272003742	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272003743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272003744	Walker A/P-loop; other site
331272003745	ATP binding site [chemical binding]; other site
331272003746	Q-loop/lid; other site
331272003747	ABC transporter signature motif; other site
331272003748	Walker B; other site
331272003749	D-loop; other site
331272003750	H-loop/switch region; other site
331272003751	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272003752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003753	dimer interface [polypeptide binding]; other site
331272003754	conserved gate region; other site
331272003755	putative PBP binding loops; other site
331272003756	ABC-ATPase subunit interface; other site
331272003757	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331272003758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003759	dimer interface [polypeptide binding]; other site
331272003760	conserved gate region; other site
331272003761	ABC-ATPase subunit interface; other site
331272003762	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272003763	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272003764	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272003765	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272003766	DNA binding site [nucleotide binding]
331272003767	domain linker motif; other site
331272003768	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
331272003769	putative dimerization interface [polypeptide binding]; other site
331272003770	putative ligand binding site [chemical binding]; other site
331272003771	oxidoreductase; Provisional; Region: PRK06128
331272003772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272003773	NAD(P) binding site [chemical binding]; other site
331272003774	active site
331272003775	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272003776	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
331272003777	NAD(P) binding site [chemical binding]; other site
331272003778	DoxX; Region: DoxX; pfam07681
331272003779	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272003780	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272003781	FMN binding site [chemical binding]; other site
331272003782	active site
331272003783	substrate binding site [chemical binding]; other site
331272003784	catalytic residue [active]
331272003785	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272003786	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003787	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272003788	dimerization interface [polypeptide binding]; other site
331272003789	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
331272003790	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
331272003791	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
331272003792	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331272003793	tetramer interface [polypeptide binding]; other site
331272003794	TPP-binding site [chemical binding]; other site
331272003795	heterodimer interface [polypeptide binding]; other site
331272003796	phosphorylation loop region [posttranslational modification]
331272003797	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331272003798	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331272003799	alpha subunit interface [polypeptide binding]; other site
331272003800	TPP binding site [chemical binding]; other site
331272003801	heterodimer interface [polypeptide binding]; other site
331272003802	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272003803	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
331272003804	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272003805	E3 interaction surface; other site
331272003806	lipoyl attachment site [posttranslational modification]; other site
331272003807	e3 binding domain; Region: E3_binding; pfam02817
331272003808	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331272003809	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
331272003810	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272003811	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272003812	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272003813	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
331272003814	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
331272003815	NAD binding site [chemical binding]; other site
331272003816	active site
331272003817	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
331272003818	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
331272003819	Na binding site [ion binding]; other site
331272003820	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272003821	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272003822	trimer interface [polypeptide binding]; other site
331272003823	eyelet of channel; other site
331272003824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272003825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003826	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272003827	dimerization interface [polypeptide binding]; other site
331272003828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003829	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272003830	putative substrate translocation pore; other site
331272003831	allantoate amidohydrolase; Reviewed; Region: PRK12893
331272003832	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
331272003833	active site
331272003834	metal binding site [ion binding]; metal-binding site
331272003835	dimer interface [polypeptide binding]; other site
331272003836	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
331272003837	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
331272003838	active site
331272003839	Zn binding site [ion binding]; other site
331272003840	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272003841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003842	putative substrate translocation pore; other site
331272003843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272003844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003845	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272003846	dimerization interface [polypeptide binding]; other site
331272003847	substrate binding pocket [chemical binding]; other site
331272003848	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
331272003849	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
331272003850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272003851	catalytic residue [active]
331272003852	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
331272003853	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
331272003854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003855	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272003856	dimerization interface [polypeptide binding]; other site
331272003857	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
331272003858	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
331272003859	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
331272003860	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
331272003861	putative dimer interface [polypeptide binding]; other site
331272003862	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
331272003863	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
331272003864	putative dimer interface [polypeptide binding]; other site
331272003865	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
331272003866	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272003867	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272003868	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272003869	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
331272003870	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272003871	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272003872	dimerization interface [polypeptide binding]; other site
331272003873	Malonate transporter MadL subunit; Region: MadL; cl04273
331272003874	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
331272003875	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
331272003876	Coenzyme A transferase; Region: CoA_trans; cl17247
331272003877	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
331272003878	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
331272003879	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
331272003880	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098
331272003881	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
331272003882	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
331272003883	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
331272003884	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
331272003885	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272003886	putative active site [active]
331272003887	catalytic site [active]
331272003888	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272003889	active site
331272003890	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
331272003891	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
331272003892	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272003893	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
331272003894	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
331272003895	N-terminal domain interface [polypeptide binding]; other site
331272003896	dimer interface [polypeptide binding]; other site
331272003897	substrate binding pocket (H-site) [chemical binding]; other site
331272003898	proline/glycine betaine transporter; Provisional; Region: PRK10642
331272003899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003900	putative substrate translocation pore; other site
331272003901	hypothetical protein; Provisional; Region: PRK02237
331272003902	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
331272003903	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
331272003904	active site
331272003905	catalytic site [active]
331272003906	substrate binding site [chemical binding]; other site
331272003907	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
331272003908	RNA/DNA hybrid binding site [nucleotide binding]; other site
331272003909	active site
331272003910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272003911	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
331272003912	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
331272003913	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272003914	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272003915	catalytic residue [active]
331272003916	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
331272003917	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272003918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272003919	D-galactonate transporter; Region: 2A0114; TIGR00893
331272003920	putative substrate translocation pore; other site
331272003921	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
331272003922	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
331272003923	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
331272003924	catalytic site [active]
331272003925	subunit interface [polypeptide binding]; other site
331272003926	leucine export protein LeuE; Provisional; Region: PRK10958
331272003927	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
331272003928	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331272003929	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
331272003930	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
331272003931	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331272003932	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331272003933	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
331272003934	IMP binding site; other site
331272003935	dimer interface [polypeptide binding]; other site
331272003936	interdomain contacts; other site
331272003937	partial ornithine binding site; other site
331272003938	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
331272003939	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
331272003940	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
331272003941	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
331272003942	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
331272003943	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
331272003944	FtsJ-like methyltransferase; Region: FtsJ; cl17430
331272003945	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
331272003946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272003947	Walker A motif; other site
331272003948	ATP binding site [chemical binding]; other site
331272003949	Walker B motif; other site
331272003950	arginine finger; other site
331272003951	Peptidase family M41; Region: Peptidase_M41; pfam01434
331272003952	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
331272003953	dihydropteroate synthase; Region: DHPS; TIGR01496
331272003954	substrate binding pocket [chemical binding]; other site
331272003955	dimer interface [polypeptide binding]; other site
331272003956	inhibitor binding site; inhibition site
331272003957	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
331272003958	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
331272003959	active site
331272003960	substrate binding site [chemical binding]; other site
331272003961	metal binding site [ion binding]; metal-binding site
331272003962	PBP superfamily domain; Region: PBP_like_2; cl17296
331272003963	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
331272003964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003965	dimer interface [polypeptide binding]; other site
331272003966	conserved gate region; other site
331272003967	putative PBP binding loops; other site
331272003968	ABC-ATPase subunit interface; other site
331272003969	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
331272003970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272003971	dimer interface [polypeptide binding]; other site
331272003972	conserved gate region; other site
331272003973	putative PBP binding loops; other site
331272003974	ABC-ATPase subunit interface; other site
331272003975	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
331272003976	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
331272003977	Walker A/P-loop; other site
331272003978	ATP binding site [chemical binding]; other site
331272003979	Q-loop/lid; other site
331272003980	ABC transporter signature motif; other site
331272003981	Walker B; other site
331272003982	D-loop; other site
331272003983	H-loop/switch region; other site
331272003984	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
331272003985	PhoU domain; Region: PhoU; pfam01895
331272003986	PhoU domain; Region: PhoU; pfam01895
331272003987	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
331272003988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272003989	active site
331272003990	phosphorylation site [posttranslational modification]
331272003991	intermolecular recognition site; other site
331272003992	dimerization interface [polypeptide binding]; other site
331272003993	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272003994	DNA binding site [nucleotide binding]
331272003995	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331272003996	PAS domain; Region: PAS; smart00091
331272003997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272003998	dimer interface [polypeptide binding]; other site
331272003999	phosphorylation site [posttranslational modification]
331272004000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272004001	ATP binding site [chemical binding]; other site
331272004002	Mg2+ binding site [ion binding]; other site
331272004003	G-X-G motif; other site
331272004004	polyphosphate kinase; Provisional; Region: PRK05443
331272004005	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
331272004006	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
331272004007	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272004008	putative active site [active]
331272004009	catalytic site [active]
331272004010	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
331272004011	putative domain interface [polypeptide binding]; other site
331272004012	putative active site [active]
331272004013	catalytic site [active]
331272004014	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
331272004015	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
331272004016	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272004017	catalytic core [active]
331272004018	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
331272004019	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
331272004020	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
331272004021	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
331272004022	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
331272004023	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
331272004024	active site
331272004025	acyl-activating enzyme (AAE) consensus motif; other site
331272004026	putative CoA binding site [chemical binding]; other site
331272004027	AMP binding site [chemical binding]; other site
331272004028	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272004029	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
331272004030	Peptidase family M23; Region: Peptidase_M23; pfam01551
331272004031	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
331272004032	active site
331272004033	catalytic residues [active]
331272004034	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
331272004035	Phage terminase, small subunit; Region: Terminase_4; pfam05119
331272004036	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
331272004037	synthetase active site [active]
331272004038	NTP binding site [chemical binding]; other site
331272004039	metal binding site [ion binding]; metal-binding site
331272004040	hypothetical protein; Provisional; Region: PRK14709
331272004041	D5 N terminal like; Region: D5_N; smart00885
331272004042	CHC2 zinc finger; Region: zf-CHC2; cl17510
331272004043	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272004044	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
331272004045	active site
331272004046	DNA binding site [nucleotide binding]
331272004047	Int/Topo IB signature motif; other site
331272004048	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
331272004049	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
331272004050	glutaminase active site [active]
331272004051	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331272004052	dimer interface [polypeptide binding]; other site
331272004053	active site
331272004054	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331272004055	dimer interface [polypeptide binding]; other site
331272004056	active site
331272004057	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
331272004058	putative active site [active]
331272004059	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
331272004060	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272004061	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
331272004062	DXD motif; other site
331272004063	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
331272004064	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
331272004065	active site
331272004066	homodimer interface [polypeptide binding]; other site
331272004067	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
331272004068	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272004069	putative NAD(P) binding site [chemical binding]; other site
331272004070	substrate binding site [chemical binding]; other site
331272004071	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
331272004072	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272004073	catalytic loop [active]
331272004074	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
331272004075	iron binding site [ion binding]; other site
331272004076	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272004077	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272004078	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272004079	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272004080	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272004081	aldolase II superfamily protein; Provisional; Region: PRK07044
331272004082	intersubunit interface [polypeptide binding]; other site
331272004083	active site
331272004084	Zn2+ binding site [ion binding]; other site
331272004085	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
331272004086	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
331272004087	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272004088	active site
331272004089	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
331272004090	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272004091	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
331272004092	NAD(P) binding site [chemical binding]; other site
331272004093	Predicted transcriptional regulators [Transcription]; Region: COG1695
331272004094	Transcriptional regulator PadR-like family; Region: PadR; cl17335
331272004095	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
331272004096	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272004097	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
331272004098	active site
331272004099	FMN binding site [chemical binding]; other site
331272004100	2,4-decadienoyl-CoA binding site; other site
331272004101	catalytic residue [active]
331272004102	4Fe-4S cluster binding site [ion binding]; other site
331272004103	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
331272004104	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272004105	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272004106	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272004107	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272004108	N-terminal plug; other site
331272004109	ligand-binding site [chemical binding]; other site
331272004110	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
331272004111	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
331272004112	Walker A/P-loop; other site
331272004113	ATP binding site [chemical binding]; other site
331272004114	Q-loop/lid; other site
331272004115	ABC transporter signature motif; other site
331272004116	Walker B; other site
331272004117	D-loop; other site
331272004118	H-loop/switch region; other site
331272004119	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
331272004120	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
331272004121	putative ligand binding residues [chemical binding]; other site
331272004122	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
331272004123	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331272004124	ABC-ATPase subunit  interface; other site
331272004125	dimer interface [polypeptide binding]; other site
331272004126	putative PBP binding regions; other site
331272004127	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272004128	dimerization interface [polypeptide binding]; other site
331272004129	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
331272004130	dimer interface [polypeptide binding]; other site
331272004131	phosphorylation site [posttranslational modification]
331272004132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272004133	ATP binding site [chemical binding]; other site
331272004134	Mg2+ binding site [ion binding]; other site
331272004135	G-X-G motif; other site
331272004136	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272004137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272004138	active site
331272004139	phosphorylation site [posttranslational modification]
331272004140	intermolecular recognition site; other site
331272004141	dimerization interface [polypeptide binding]; other site
331272004142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272004143	DNA binding site [nucleotide binding]
331272004144	MltA-interacting protein MipA; Region: MipA; cl01504
331272004145	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272004146	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272004147	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272004148	catalytic residue [active]
331272004149	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
331272004150	VirB7 interaction site; other site
331272004151	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272004152	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272004153	trimer interface [polypeptide binding]; other site
331272004154	eyelet of channel; other site
331272004155	RNA polymerase sigma factor; Provisional; Region: PRK12528
331272004156	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272004157	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272004158	DNA binding residues [nucleotide binding]
331272004159	fec operon regulator FecR; Reviewed; Region: PRK09774
331272004160	FecR protein; Region: FecR; pfam04773
331272004161	Secretin and TonB N terminus short domain; Region: STN; smart00965
331272004162	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272004163	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272004164	N-terminal plug; other site
331272004165	ligand-binding site [chemical binding]; other site
331272004166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004168	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
331272004169	putative dimerization interface [polypeptide binding]; other site
331272004170	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
331272004171	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272004172	putative metal binding site [ion binding]; other site
331272004173	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
331272004174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004176	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272004177	putative dimerization interface [polypeptide binding]; other site
331272004178	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
331272004179	Citrate transporter; Region: CitMHS; pfam03600
331272004180	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
331272004181	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
331272004182	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
331272004183	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
331272004184	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331272004185	putative acyl-acceptor binding pocket; other site
331272004186	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
331272004187	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
331272004188	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272004189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272004190	S-adenosylmethionine binding site [chemical binding]; other site
331272004191	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
331272004192	active site
331272004193	GAF domain; Region: GAF_2; pfam13185
331272004194	GAF domain; Region: GAF_3; pfam13492
331272004195	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272004196	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272004197	metal binding site [ion binding]; metal-binding site
331272004198	active site
331272004199	I-site; other site
331272004200	cellulose synthase regulator protein; Provisional; Region: PRK11114
331272004201	endo-1,4-D-glucanase; Provisional; Region: PRK11097
331272004202	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
331272004203	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331272004204	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
331272004205	cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369
331272004206	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
331272004207	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
331272004208	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
331272004209	DXD motif; other site
331272004210	PilZ domain; Region: PilZ; pfam07238
331272004211	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
331272004212	Pirin-related protein [General function prediction only]; Region: COG1741
331272004213	Pirin; Region: Pirin; pfam02678
331272004214	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
331272004215	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
331272004216	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
331272004217	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
331272004218	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
331272004219	Isochorismatase family; Region: Isochorismatase; pfam00857
331272004220	catalytic triad [active]
331272004221	dimer interface [polypeptide binding]; other site
331272004222	conserved cis-peptide bond; other site
331272004223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004225	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272004226	putative effector binding pocket; other site
331272004227	dimerization interface [polypeptide binding]; other site
331272004228	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
331272004229	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
331272004230	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
331272004231	active site
331272004232	Predicted membrane protein [Function unknown]; Region: COG2259
331272004233	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331272004234	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
331272004235	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
331272004236	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
331272004237	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
331272004238	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
331272004239	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
331272004240	nudix motif; other site
331272004241	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
331272004242	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272004243	active site
331272004244	HIGH motif; other site
331272004245	nucleotide binding site [chemical binding]; other site
331272004246	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272004247	active site
331272004248	KMSKS motif; other site
331272004249	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
331272004250	Serine hydrolase; Region: Ser_hydrolase; pfam06821
331272004251	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272004252	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272004253	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
331272004254	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
331272004255	motif 1; other site
331272004256	active site
331272004257	motif 2; other site
331272004258	motif 3; other site
331272004259	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
331272004260	DHHA1 domain; Region: DHHA1; pfam02272
331272004261	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004263	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272004264	dimerization interface [polypeptide binding]; other site
331272004265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004266	putative substrate translocation pore; other site
331272004267	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
331272004268	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331272004269	nudix motif; other site
331272004270	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331272004271	active site
331272004272	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272004273	TM-ABC transporter signature motif; other site
331272004274	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272004275	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272004276	TM-ABC transporter signature motif; other site
331272004277	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272004278	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272004279	Walker A/P-loop; other site
331272004280	ATP binding site [chemical binding]; other site
331272004281	Q-loop/lid; other site
331272004282	ABC transporter signature motif; other site
331272004283	Walker B; other site
331272004284	D-loop; other site
331272004285	H-loop/switch region; other site
331272004286	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272004287	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272004288	Walker A/P-loop; other site
331272004289	ATP binding site [chemical binding]; other site
331272004290	Q-loop/lid; other site
331272004291	ABC transporter signature motif; other site
331272004292	Walker B; other site
331272004293	D-loop; other site
331272004294	H-loop/switch region; other site
331272004295	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
331272004296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272004297	NAD(P) binding site [chemical binding]; other site
331272004298	active site
331272004299	hypothetical protein; Provisional; Region: PRK02487
331272004300	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
331272004301	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
331272004302	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
331272004303	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272004304	dimer interface [polypeptide binding]; other site
331272004305	PYR/PP interface [polypeptide binding]; other site
331272004306	TPP binding site [chemical binding]; other site
331272004307	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272004308	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
331272004309	TPP-binding site [chemical binding]; other site
331272004310	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272004311	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
331272004312	substrate binding site [chemical binding]; other site
331272004313	ATP binding site [chemical binding]; other site
331272004314	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
331272004315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
331272004316	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
331272004317	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272004318	putative ligand binding site [chemical binding]; other site
331272004319	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272004320	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272004321	Walker A/P-loop; other site
331272004322	ATP binding site [chemical binding]; other site
331272004323	Q-loop/lid; other site
331272004324	ABC transporter signature motif; other site
331272004325	Walker B; other site
331272004326	D-loop; other site
331272004327	H-loop/switch region; other site
331272004328	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272004329	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272004330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272004331	TM-ABC transporter signature motif; other site
331272004332	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
331272004333	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
331272004334	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272004335	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
331272004336	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
331272004337	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
331272004338	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272004339	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
331272004340	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272004341	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272004342	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272004343	putative active site [active]
331272004344	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
331272004345	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
331272004346	tetrameric interface [polypeptide binding]; other site
331272004347	NAD binding site [chemical binding]; other site
331272004348	catalytic residues [active]
331272004349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004351	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272004352	putative effector binding pocket; other site
331272004353	dimerization interface [polypeptide binding]; other site
331272004354	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
331272004355	CPxP  motif; other site
331272004356	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272004357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272004358	active site
331272004359	phosphorylation site [posttranslational modification]
331272004360	intermolecular recognition site; other site
331272004361	dimerization interface [polypeptide binding]; other site
331272004362	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272004363	DNA binding site [nucleotide binding]
331272004364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
331272004365	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272004366	FecR protein; Region: FecR; pfam04773
331272004367	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
331272004368	CHASE2 domain; Region: CHASE2; pfam05226
331272004369	PAS domain; Region: PAS_9; pfam13426
331272004370	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272004371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272004372	dimer interface [polypeptide binding]; other site
331272004373	phosphorylation site [posttranslational modification]
331272004374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272004375	ATP binding site [chemical binding]; other site
331272004376	Mg2+ binding site [ion binding]; other site
331272004377	G-X-G motif; other site
331272004378	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
331272004379	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
331272004380	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
331272004381	active site
331272004382	tetramer interface; other site
331272004383	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
331272004384	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
331272004385	HIGH motif; other site
331272004386	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
331272004387	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
331272004388	active site
331272004389	KMSKS motif; other site
331272004390	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
331272004391	tRNA binding surface [nucleotide binding]; other site
331272004392	anticodon binding site; other site
331272004393	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
331272004394	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
331272004395	Part of AAA domain; Region: AAA_19; pfam13245
331272004396	Family description; Region: UvrD_C_2; pfam13538
331272004397	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
331272004398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004399	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272004400	putative substrate translocation pore; other site
331272004401	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272004402	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272004403	dimer interface [polypeptide binding]; other site
331272004404	putative CheW interface [polypeptide binding]; other site
331272004405	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
331272004406	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272004407	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272004408	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
331272004409	Fusaric acid resistance protein family; Region: FUSC; pfam04632
331272004410	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272004411	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272004412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004414	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272004415	putative effector binding pocket; other site
331272004416	dimerization interface [polypeptide binding]; other site
331272004417	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
331272004418	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
331272004419	putative active site [active]
331272004420	putative metal binding site [ion binding]; other site
331272004421	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272004422	FAD binding domain; Region: FAD_binding_4; pfam01565
331272004423	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
331272004424	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
331272004425	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272004426	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
331272004427	Protein of unknown function (DUF962); Region: DUF962; cl01879
331272004428	FOG: CBS domain [General function prediction only]; Region: COG0517
331272004429	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
331272004430	H+ Antiporter protein; Region: 2A0121; TIGR00900
331272004431	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
331272004432	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331272004433	putative acyl-acceptor binding pocket; other site
331272004434	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
331272004435	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
331272004436	Tetramer interface [polypeptide binding]; other site
331272004437	active site
331272004438	FMN-binding site [chemical binding]; other site
331272004439	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
331272004440	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272004441	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
331272004442	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
331272004443	short chain dehydrogenase; Provisional; Region: PRK06949
331272004444	classical (c) SDRs; Region: SDR_c; cd05233
331272004445	NAD(P) binding site [chemical binding]; other site
331272004446	active site
331272004447	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331272004448	active site
331272004449	PAS domain; Region: PAS_9; pfam13426
331272004450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272004451	putative active site [active]
331272004452	heme pocket [chemical binding]; other site
331272004453	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272004454	DNA binding residues [nucleotide binding]
331272004455	dimerization interface [polypeptide binding]; other site
331272004456	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
331272004457	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
331272004458	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
331272004459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272004460	NAD(P) binding site [chemical binding]; other site
331272004461	active site
331272004462	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
331272004463	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
331272004464	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
331272004465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004466	transcriptional activator TtdR; Provisional; Region: PRK09801
331272004467	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272004468	putative effector binding pocket; other site
331272004469	dimerization interface [polypeptide binding]; other site
331272004470	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272004471	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272004472	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
331272004473	homotrimer interaction site [polypeptide binding]; other site
331272004474	putative active site [active]
331272004475	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
331272004476	HD domain; Region: HD_4; pfam13328
331272004477	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
331272004478	synthetase active site [active]
331272004479	NTP binding site [chemical binding]; other site
331272004480	metal binding site [ion binding]; metal-binding site
331272004481	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
331272004482	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
331272004483	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
331272004484	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
331272004485	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
331272004486	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
331272004487	active site
331272004488	dimer interface [polypeptide binding]; other site
331272004489	motif 1; other site
331272004490	motif 2; other site
331272004491	motif 3; other site
331272004492	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
331272004493	anticodon binding site; other site
331272004494	translation initiation factor IF-3; Region: infC; TIGR00168
331272004495	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
331272004496	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
331272004497	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
331272004498	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
331272004499	23S rRNA binding site [nucleotide binding]; other site
331272004500	L21 binding site [polypeptide binding]; other site
331272004501	L13 binding site [polypeptide binding]; other site
331272004502	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
331272004503	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
331272004504	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
331272004505	dimer interface [polypeptide binding]; other site
331272004506	motif 1; other site
331272004507	active site
331272004508	motif 2; other site
331272004509	motif 3; other site
331272004510	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
331272004511	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
331272004512	putative tRNA-binding site [nucleotide binding]; other site
331272004513	B3/4 domain; Region: B3_4; pfam03483
331272004514	tRNA synthetase B5 domain; Region: B5; smart00874
331272004515	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
331272004516	dimer interface [polypeptide binding]; other site
331272004517	motif 1; other site
331272004518	motif 3; other site
331272004519	motif 2; other site
331272004520	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
331272004521	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
331272004522	IHF dimer interface [polypeptide binding]; other site
331272004523	IHF - DNA interface [nucleotide binding]; other site
331272004524	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
331272004525	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331272004526	DNA binding residues [nucleotide binding]
331272004527	Domain of unknown function (DUF811); Region: DUF811; pfam05665
331272004528	Domain of unknown function (DUF811); Region: DUF811; pfam05665
331272004529	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331272004530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331272004531	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
331272004532	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
331272004533	Uncharacterized conserved protein [Function unknown]; Region: COG1359
331272004534	Uncharacterized conserved protein [Function unknown]; Region: COG1434
331272004535	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
331272004536	putative active site [active]
331272004537	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331272004538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004540	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272004541	putative dimerization interface [polypeptide binding]; other site
331272004542	aspartate aminotransferase; Provisional; Region: PRK06108
331272004543	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272004544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272004545	homodimer interface [polypeptide binding]; other site
331272004546	catalytic residue [active]
331272004547	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
331272004548	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
331272004549	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272004550	RNA binding surface [nucleotide binding]; other site
331272004551	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
331272004552	probable active site [active]
331272004553	ribosome maturation protein RimP; Reviewed; Region: PRK00092
331272004554	Sm and related proteins; Region: Sm_like; cl00259
331272004555	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
331272004556	putative oligomer interface [polypeptide binding]; other site
331272004557	putative RNA binding site [nucleotide binding]; other site
331272004558	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
331272004559	NusA N-terminal domain; Region: NusA_N; pfam08529
331272004560	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
331272004561	RNA binding site [nucleotide binding]; other site
331272004562	homodimer interface [polypeptide binding]; other site
331272004563	NusA-like KH domain; Region: KH_5; pfam13184
331272004564	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
331272004565	G-X-X-G motif; other site
331272004566	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
331272004567	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
331272004568	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
331272004569	translation initiation factor IF-2; Region: IF-2; TIGR00487
331272004570	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
331272004571	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
331272004572	G1 box; other site
331272004573	putative GEF interaction site [polypeptide binding]; other site
331272004574	GTP/Mg2+ binding site [chemical binding]; other site
331272004575	Switch I region; other site
331272004576	G2 box; other site
331272004577	G3 box; other site
331272004578	Switch II region; other site
331272004579	G4 box; other site
331272004580	G5 box; other site
331272004581	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
331272004582	Translation-initiation factor 2; Region: IF-2; pfam11987
331272004583	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
331272004584	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
331272004585	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
331272004586	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
331272004587	RNA binding site [nucleotide binding]; other site
331272004588	active site
331272004589	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
331272004590	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272004591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004592	putative substrate translocation pore; other site
331272004593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004594	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
331272004595	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272004596	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272004597	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272004598	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272004599	MarR family; Region: MarR_2; cl17246
331272004600	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
331272004601	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
331272004602	G1 box; other site
331272004603	putative GEF interaction site [polypeptide binding]; other site
331272004604	GTP/Mg2+ binding site [chemical binding]; other site
331272004605	Switch I region; other site
331272004606	G2 box; other site
331272004607	G3 box; other site
331272004608	Switch II region; other site
331272004609	G4 box; other site
331272004610	G5 box; other site
331272004611	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
331272004612	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
331272004613	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
331272004614	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
331272004615	TPP-binding site [chemical binding]; other site
331272004616	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
331272004617	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272004618	E3 interaction surface; other site
331272004619	lipoyl attachment site [posttranslational modification]; other site
331272004620	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
331272004621	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331272004622	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
331272004623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272004624	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272004625	Predicted ATPase [General function prediction only]; Region: COG1485
331272004626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272004627	Walker B; other site
331272004628	D-loop; other site
331272004629	H-loop/switch region; other site
331272004630	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331272004631	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
331272004632	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
331272004633	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
331272004634	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
331272004635	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
331272004636	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
331272004637	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
331272004638	TadE-like protein; Region: TadE; pfam07811
331272004639	Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177
331272004640	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
331272004641	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
331272004642	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331272004643	AAA domain; Region: AAA_31; pfam13614
331272004644	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
331272004645	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
331272004646	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
331272004647	ATP binding site [chemical binding]; other site
331272004648	Walker A motif; other site
331272004649	hexamer interface [polypeptide binding]; other site
331272004650	Walker B motif; other site
331272004651	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
331272004652	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272004653	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
331272004654	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272004655	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
331272004656	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
331272004657	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
331272004658	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
331272004659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272004660	Walker A motif; other site
331272004661	ATP binding site [chemical binding]; other site
331272004662	Walker B motif; other site
331272004663	arginine finger; other site
331272004664	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272004665	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
331272004666	bacterial Hfq-like; Region: Hfq; cd01716
331272004667	hexamer interface [polypeptide binding]; other site
331272004668	Sm1 motif; other site
331272004669	RNA binding site [nucleotide binding]; other site
331272004670	Sm2 motif; other site
331272004671	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
331272004672	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
331272004673	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
331272004674	acyl-activating enzyme (AAE) consensus motif; other site
331272004675	putative AMP binding site [chemical binding]; other site
331272004676	putative active site [active]
331272004677	putative CoA binding site [chemical binding]; other site
331272004678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272004679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272004680	putative sialic acid transporter; Region: 2A0112; TIGR00891
331272004681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004682	putative substrate translocation pore; other site
331272004683	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272004684	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272004685	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
331272004686	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
331272004687	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
331272004688	Sulfate transporter family; Region: Sulfate_transp; pfam00916
331272004689	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
331272004690	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
331272004691	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272004692	putative substrate binding site [chemical binding]; other site
331272004693	putative ATP binding site [chemical binding]; other site
331272004694	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
331272004695	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272004696	putative ligand binding site [chemical binding]; other site
331272004697	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272004698	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272004699	TM-ABC transporter signature motif; other site
331272004700	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272004701	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272004702	Walker A/P-loop; other site
331272004703	ATP binding site [chemical binding]; other site
331272004704	Q-loop/lid; other site
331272004705	ABC transporter signature motif; other site
331272004706	Walker B; other site
331272004707	D-loop; other site
331272004708	H-loop/switch region; other site
331272004709	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272004710	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272004711	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
331272004712	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
331272004713	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272004714	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272004715	substrate binding pocket [chemical binding]; other site
331272004716	membrane-bound complex binding site; other site
331272004717	hinge residues; other site
331272004718	ribonuclease R; Region: RNase_R; TIGR02063
331272004719	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
331272004720	RNB domain; Region: RNB; pfam00773
331272004721	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
331272004722	RNA binding site [nucleotide binding]; other site
331272004723	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
331272004724	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
331272004725	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331272004726	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
331272004727	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
331272004728	amidase catalytic site [active]
331272004729	Zn binding residues [ion binding]; other site
331272004730	substrate binding site [chemical binding]; other site
331272004731	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
331272004732	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
331272004733	tetramer (dimer of dimers) interface [polypeptide binding]; other site
331272004734	active site
331272004735	dimer interface [polypeptide binding]; other site
331272004736	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272004737	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272004738	DNA-binding site [nucleotide binding]; DNA binding site
331272004739	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272004740	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
331272004741	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272004742	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272004743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004744	dimer interface [polypeptide binding]; other site
331272004745	conserved gate region; other site
331272004746	putative PBP binding loops; other site
331272004747	ABC-ATPase subunit interface; other site
331272004748	cystine transporter subunit; Provisional; Region: PRK11260
331272004749	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272004750	substrate binding pocket [chemical binding]; other site
331272004751	membrane-bound complex binding site; other site
331272004752	hinge residues; other site
331272004753	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
331272004754	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
331272004755	quinone interaction residues [chemical binding]; other site
331272004756	active site
331272004757	catalytic residues [active]
331272004758	FMN binding site [chemical binding]; other site
331272004759	substrate binding site [chemical binding]; other site
331272004760	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
331272004761	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
331272004762	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
331272004763	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
331272004764	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
331272004765	nudix motif; other site
331272004766	hypothetical protein; Provisional; Region: PRK02487
331272004767	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
331272004768	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
331272004769	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272004770	substrate binding site [chemical binding]; other site
331272004771	oxyanion hole (OAH) forming residues; other site
331272004772	trimer interface [polypeptide binding]; other site
331272004773	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
331272004774	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
331272004775	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
331272004776	active site
331272004777	dimer interface [polypeptide binding]; other site
331272004778	non-prolyl cis peptide bond; other site
331272004779	insertion regions; other site
331272004780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272004781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004782	dimer interface [polypeptide binding]; other site
331272004783	conserved gate region; other site
331272004784	putative PBP binding loops; other site
331272004785	ABC-ATPase subunit interface; other site
331272004786	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
331272004787	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272004788	Walker A/P-loop; other site
331272004789	ATP binding site [chemical binding]; other site
331272004790	Q-loop/lid; other site
331272004791	ABC transporter signature motif; other site
331272004792	Walker B; other site
331272004793	D-loop; other site
331272004794	H-loop/switch region; other site
331272004795	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
331272004796	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
331272004797	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
331272004798	FMN binding site [chemical binding]; other site
331272004799	active site
331272004800	catalytic residues [active]
331272004801	substrate binding site [chemical binding]; other site
331272004802	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272004803	active site
331272004804	Int/Topo IB signature motif; other site
331272004805	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
331272004806	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
331272004807	dimerization interface [polypeptide binding]; other site
331272004808	mannose binding site [chemical binding]; other site
331272004809	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
331272004810	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
331272004811	dimerization interface [polypeptide binding]; other site
331272004812	mannose binding site [chemical binding]; other site
331272004813	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
331272004814	dimerization interface [polypeptide binding]; other site
331272004815	D-mannose binding lectin; Region: B_lectin; pfam01453
331272004816	mannose binding site [chemical binding]; other site
331272004817	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
331272004818	dimerization interface [polypeptide binding]; other site
331272004819	D-mannose binding lectin; Region: B_lectin; pfam01453
331272004820	mannose binding site [chemical binding]; other site
331272004821	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
331272004822	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331272004823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272004824	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272004825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272004826	Coenzyme A binding pocket [chemical binding]; other site
331272004827	Family of unknown function (DUF695); Region: DUF695; pfam05117
331272004828	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
331272004829	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
331272004830	putative dimer interface [polypeptide binding]; other site
331272004831	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272004832	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
331272004833	PLD-like domain; Region: PLDc_2; pfam13091
331272004834	putative active site [active]
331272004835	catalytic site [active]
331272004836	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272004837	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272004838	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
331272004839	CoenzymeA binding site [chemical binding]; other site
331272004840	subunit interaction site [polypeptide binding]; other site
331272004841	PHB binding site; other site
331272004842	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272004843	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272004844	active site
331272004845	catalytic tetrad [active]
331272004846	citrate-proton symporter; Provisional; Region: PRK15075
331272004847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004848	putative substrate translocation pore; other site
331272004849	hypothetical protein; Provisional; Region: PRK07079
331272004850	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
331272004851	metal binding site [ion binding]; metal-binding site
331272004852	putative dimer interface [polypeptide binding]; other site
331272004853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272004854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004855	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272004856	dimerization interface [polypeptide binding]; other site
331272004857	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
331272004858	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
331272004859	active site residue [active]
331272004860	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
331272004861	Predicted permease; Region: DUF318; cl17795
331272004862	ABC-2 type transporter; Region: ABC2_membrane; cl17235
331272004863	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
331272004864	nodulation ABC transporter NodI; Provisional; Region: PRK13537
331272004865	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
331272004866	Walker A/P-loop; other site
331272004867	ATP binding site [chemical binding]; other site
331272004868	Q-loop/lid; other site
331272004869	ABC transporter signature motif; other site
331272004870	Walker B; other site
331272004871	D-loop; other site
331272004872	H-loop/switch region; other site
331272004873	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272004874	Ligand Binding Site [chemical binding]; other site
331272004875	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
331272004876	LexA repressor; Validated; Region: PRK00215
331272004877	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
331272004878	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
331272004879	Catalytic site [active]
331272004880	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272004881	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
331272004882	substrate binding pocket [chemical binding]; other site
331272004883	membrane-bound complex binding site; other site
331272004884	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331272004885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004886	dimer interface [polypeptide binding]; other site
331272004887	conserved gate region; other site
331272004888	putative PBP binding loops; other site
331272004889	ABC-ATPase subunit interface; other site
331272004890	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331272004891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004892	dimer interface [polypeptide binding]; other site
331272004893	conserved gate region; other site
331272004894	putative PBP binding loops; other site
331272004895	ABC-ATPase subunit interface; other site
331272004896	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
331272004897	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
331272004898	Walker A/P-loop; other site
331272004899	ATP binding site [chemical binding]; other site
331272004900	Q-loop/lid; other site
331272004901	ABC transporter signature motif; other site
331272004902	Walker B; other site
331272004903	D-loop; other site
331272004904	H-loop/switch region; other site
331272004905	TOBE-like domain; Region: TOBE_3; pfam12857
331272004906	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
331272004907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272004908	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
331272004909	substrate binding site [chemical binding]; other site
331272004910	dimerization interface [polypeptide binding]; other site
331272004911	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
331272004912	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272004913	ligand binding site [chemical binding]; other site
331272004914	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272004915	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272004916	Walker A/P-loop; other site
331272004917	ATP binding site [chemical binding]; other site
331272004918	Q-loop/lid; other site
331272004919	ABC transporter signature motif; other site
331272004920	Walker B; other site
331272004921	D-loop; other site
331272004922	H-loop/switch region; other site
331272004923	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272004924	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
331272004925	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272004926	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272004927	TM-ABC transporter signature motif; other site
331272004928	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272004929	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272004930	DNA binding site [nucleotide binding]
331272004931	domain linker motif; other site
331272004932	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
331272004933	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272004934	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
331272004935	substrate binding site [chemical binding]; other site
331272004936	dimer interface [polypeptide binding]; other site
331272004937	ATP binding site [chemical binding]; other site
331272004938	Tar ligand binding domain homologue; Region: TarH; pfam02203
331272004939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272004940	dimerization interface [polypeptide binding]; other site
331272004941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272004942	dimer interface [polypeptide binding]; other site
331272004943	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
331272004944	putative CheW interface [polypeptide binding]; other site
331272004945	PrkA family serine protein kinase; Provisional; Region: PRK15455
331272004946	AAA ATPase domain; Region: AAA_16; pfam13191
331272004947	Walker A motif; other site
331272004948	ATP binding site [chemical binding]; other site
331272004949	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
331272004950	hypothetical protein; Provisional; Region: PRK05325
331272004951	SpoVR family protein; Provisional; Region: PRK11767
331272004952	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
331272004953	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
331272004954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272004955	putative substrate translocation pore; other site
331272004956	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272004957	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272004958	substrate binding pocket [chemical binding]; other site
331272004959	membrane-bound complex binding site; other site
331272004960	hinge residues; other site
331272004961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004962	dimer interface [polypeptide binding]; other site
331272004963	conserved gate region; other site
331272004964	putative PBP binding loops; other site
331272004965	ABC-ATPase subunit interface; other site
331272004966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272004967	dimer interface [polypeptide binding]; other site
331272004968	conserved gate region; other site
331272004969	putative PBP binding loops; other site
331272004970	ABC-ATPase subunit interface; other site
331272004971	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
331272004972	Peptidase family M23; Region: Peptidase_M23; pfam01551
331272004973	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
331272004974	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272004975	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
331272004976	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
331272004977	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272004978	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272004979	multidrug efflux protein; Reviewed; Region: PRK09577
331272004980	Protein export membrane protein; Region: SecD_SecF; cl14618
331272004981	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272004982	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
331272004983	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
331272004984	PapC N-terminal domain; Region: PapC_N; pfam13954
331272004985	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
331272004986	PapC C-terminal domain; Region: PapC_C; pfam13953
331272004987	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
331272004988	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
331272004989	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
331272004990	Fimbrial protein; Region: Fimbrial; pfam00419
331272004991	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
331272004992	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272004993	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
331272004994	MbtH-like protein; Region: MbtH; cl01279
331272004995	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272004996	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
331272004997	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
331272004998	Walker A/P-loop; other site
331272004999	ATP binding site [chemical binding]; other site
331272005000	Q-loop/lid; other site
331272005001	ABC transporter signature motif; other site
331272005002	Walker B; other site
331272005003	D-loop; other site
331272005004	H-loop/switch region; other site
331272005005	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
331272005006	FecCD transport family; Region: FecCD; pfam01032
331272005007	ABC-ATPase subunit  interface; other site
331272005008	dimer interface [polypeptide binding]; other site
331272005009	putative PBP binding regions; other site
331272005010	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331272005011	ABC-ATPase subunit  interface; other site
331272005012	dimer interface [polypeptide binding]; other site
331272005013	putative PBP binding regions; other site
331272005014	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
331272005015	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
331272005016	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
331272005017	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
331272005018	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
331272005019	siderophore binding site; other site
331272005020	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
331272005021	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
331272005022	Walker A/P-loop; other site
331272005023	ATP binding site [chemical binding]; other site
331272005024	Q-loop/lid; other site
331272005025	ABC transporter signature motif; other site
331272005026	Walker B; other site
331272005027	D-loop; other site
331272005028	H-loop/switch region; other site
331272005029	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
331272005030	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331272005031	acyl-activating enzyme (AAE) consensus motif; other site
331272005032	AMP binding site [chemical binding]; other site
331272005033	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272005034	Condensation domain; Region: Condensation; pfam00668
331272005035	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272005036	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
331272005037	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272005038	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331272005039	acyl-activating enzyme (AAE) consensus motif; other site
331272005040	AMP binding site [chemical binding]; other site
331272005041	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272005042	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
331272005043	Condensation domain; Region: Condensation; pfam00668
331272005044	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272005045	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331272005046	acyl-activating enzyme (AAE) consensus motif; other site
331272005047	AMP binding site [chemical binding]; other site
331272005048	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272005049	Condensation domain; Region: Condensation; pfam00668
331272005050	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272005051	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
331272005052	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331272005053	acyl-activating enzyme (AAE) consensus motif; other site
331272005054	AMP binding site [chemical binding]; other site
331272005055	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272005056	Condensation domain; Region: Condensation; pfam00668
331272005057	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272005058	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
331272005059	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272005060	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
331272005061	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
331272005062	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
331272005063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272005064	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
331272005065	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272005066	N-terminal plug; other site
331272005067	ligand-binding site [chemical binding]; other site
331272005068	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
331272005069	catalytic site [active]
331272005070	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
331272005071	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
331272005072	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
331272005073	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
331272005074	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272005075	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272005076	metal binding site [ion binding]; metal-binding site
331272005077	putative dimer interface [polypeptide binding]; other site
331272005078	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
331272005079	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
331272005080	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
331272005081	catalytic triad [active]
331272005082	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
331272005083	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
331272005084	homodimer interface [polypeptide binding]; other site
331272005085	Walker A motif; other site
331272005086	ATP binding site [chemical binding]; other site
331272005087	hydroxycobalamin binding site [chemical binding]; other site
331272005088	Walker B motif; other site
331272005089	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
331272005090	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
331272005091	active site
331272005092	SAM binding site [chemical binding]; other site
331272005093	homodimer interface [polypeptide binding]; other site
331272005094	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272005095	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272005096	N-terminal plug; other site
331272005097	ligand-binding site [chemical binding]; other site
331272005098	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
331272005099	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
331272005100	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
331272005101	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
331272005102	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
331272005103	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
331272005104	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
331272005105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005106	Walker A motif; other site
331272005107	ATP binding site [chemical binding]; other site
331272005108	Walker B motif; other site
331272005109	arginine finger; other site
331272005110	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
331272005111	metal ion-dependent adhesion site (MIDAS); other site
331272005112	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
331272005113	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272005114	binding surface
331272005115	TPR motif; other site
331272005116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272005117	binding surface
331272005118	TPR motif; other site
331272005119	TPR repeat; Region: TPR_11; pfam13414
331272005120	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331272005121	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272005122	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
331272005123	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
331272005124	active site
331272005125	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
331272005126	nudix motif; other site
331272005127	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272005128	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272005129	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
331272005130	Citrate transporter; Region: CitMHS; pfam03600
331272005131	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272005132	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272005133	active site
331272005134	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272005135	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
331272005136	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272005137	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
331272005138	active site
331272005139	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
331272005140	aromatic chitin/cellulose binding site residues [chemical binding]; other site
331272005141	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
331272005142	aromatic chitin/cellulose binding site residues [chemical binding]; other site
331272005143	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
331272005144	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
331272005145	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
331272005146	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
331272005147	active site
331272005148	SAM binding site [chemical binding]; other site
331272005149	homodimer interface [polypeptide binding]; other site
331272005150	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
331272005151	active site
331272005152	SAM binding site [chemical binding]; other site
331272005153	homodimer interface [polypeptide binding]; other site
331272005154	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
331272005155	Precorrin-8X methylmutase; Region: CbiC; pfam02570
331272005156	precorrin-3B synthase; Region: CobG; TIGR02435
331272005157	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
331272005158	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
331272005159	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
331272005160	active site
331272005161	putative homodimer interface [polypeptide binding]; other site
331272005162	SAM binding site [chemical binding]; other site
331272005163	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
331272005164	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
331272005165	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
331272005166	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
331272005167	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
331272005168	active site
331272005169	SAM binding site [chemical binding]; other site
331272005170	homodimer interface [polypeptide binding]; other site
331272005171	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
331272005172	MarR family; Region: MarR_2; cl17246
331272005173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272005174	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272005175	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
331272005176	C-terminal domain interface [polypeptide binding]; other site
331272005177	GSH binding site (G-site) [chemical binding]; other site
331272005178	dimer interface [polypeptide binding]; other site
331272005179	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
331272005180	dimer interface [polypeptide binding]; other site
331272005181	N-terminal domain interface [polypeptide binding]; other site
331272005182	Transposase, Mutator family; Region: Transposase_mut; pfam00872
331272005183	MULE transposase domain; Region: MULE; pfam10551
331272005184	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
331272005185	hypothetical protein; Provisional; Region: PRK11622
331272005186	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272005187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272005188	Walker A/P-loop; other site
331272005189	ATP binding site [chemical binding]; other site
331272005190	Q-loop/lid; other site
331272005191	ABC transporter signature motif; other site
331272005192	Walker B; other site
331272005193	D-loop; other site
331272005194	H-loop/switch region; other site
331272005195	TOBE domain; Region: TOBE_2; pfam08402
331272005196	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331272005197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005198	dimer interface [polypeptide binding]; other site
331272005199	conserved gate region; other site
331272005200	putative PBP binding loops; other site
331272005201	ABC-ATPase subunit interface; other site
331272005202	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272005203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005204	dimer interface [polypeptide binding]; other site
331272005205	conserved gate region; other site
331272005206	putative PBP binding loops; other site
331272005207	ABC-ATPase subunit interface; other site
331272005208	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
331272005209	glycerate dehydrogenase; Provisional; Region: PRK06487
331272005210	putative ligand binding site [chemical binding]; other site
331272005211	putative NAD binding site [chemical binding]; other site
331272005212	catalytic site [active]
331272005213	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272005214	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272005215	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
331272005216	active site
331272005217	catalytic residues [active]
331272005218	metal binding site [ion binding]; metal-binding site
331272005219	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
331272005220	dimer interface [polypeptide binding]; other site
331272005221	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272005222	metal binding site [ion binding]; metal-binding site
331272005223	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272005224	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272005225	substrate binding pocket [chemical binding]; other site
331272005226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272005227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272005228	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
331272005229	putative dimerization interface [polypeptide binding]; other site
331272005230	benzoate transport; Region: 2A0115; TIGR00895
331272005231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272005232	putative substrate translocation pore; other site
331272005233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272005234	putative substrate translocation pore; other site
331272005235	Uncharacterized conserved protein [Function unknown]; Region: COG3791
331272005236	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272005237	MarR family; Region: MarR; pfam01047
331272005238	Predicted acetyltransferase [General function prediction only]; Region: COG3393
331272005239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272005240	Coenzyme A binding pocket [chemical binding]; other site
331272005241	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272005242	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272005243	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
331272005244	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
331272005245	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
331272005246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
331272005247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
331272005248	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331272005249	Protein export membrane protein; Region: SecD_SecF; cl14618
331272005250	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
331272005251	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272005252	Walker A/P-loop; other site
331272005253	ATP binding site [chemical binding]; other site
331272005254	Q-loop/lid; other site
331272005255	ABC transporter signature motif; other site
331272005256	Walker B; other site
331272005257	D-loop; other site
331272005258	H-loop/switch region; other site
331272005259	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272005260	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272005261	Walker A/P-loop; other site
331272005262	ATP binding site [chemical binding]; other site
331272005263	Q-loop/lid; other site
331272005264	ABC transporter signature motif; other site
331272005265	Walker B; other site
331272005266	D-loop; other site
331272005267	H-loop/switch region; other site
331272005268	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272005269	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
331272005270	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
331272005271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005272	dimer interface [polypeptide binding]; other site
331272005273	conserved gate region; other site
331272005274	putative PBP binding loops; other site
331272005275	ABC-ATPase subunit interface; other site
331272005276	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
331272005277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005278	dimer interface [polypeptide binding]; other site
331272005279	conserved gate region; other site
331272005280	putative PBP binding loops; other site
331272005281	ABC-ATPase subunit interface; other site
331272005282	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331272005283	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
331272005284	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
331272005285	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
331272005286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
331272005287	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
331272005288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272005289	non-specific DNA binding site [nucleotide binding]; other site
331272005290	salt bridge; other site
331272005291	sequence-specific DNA binding site [nucleotide binding]; other site
331272005292	Cupin domain; Region: Cupin_2; pfam07883
331272005293	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272005294	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
331272005295	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
331272005296	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272005297	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
331272005298	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
331272005299	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
331272005300	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
331272005301	putative deacylase active site [active]
331272005302	YciI-like protein; Reviewed; Region: PRK12866
331272005303	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
331272005304	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
331272005305	oligomer interface [polypeptide binding]; other site
331272005306	metal binding site [ion binding]; metal-binding site
331272005307	metal binding site [ion binding]; metal-binding site
331272005308	putative Cl binding site [ion binding]; other site
331272005309	basic sphincter; other site
331272005310	hydrophobic gate; other site
331272005311	periplasmic entrance; other site
331272005312	AAA domain; Region: AAA_33; pfam13671
331272005313	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
331272005314	active site
331272005315	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
331272005316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272005317	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272005318	AsnC family; Region: AsnC_trans_reg; pfam01037
331272005319	LTXXQ motif family protein; Region: LTXXQ; pfam07813
331272005320	PGDYG protein; Region: PGDYG; pfam14083
331272005321	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
331272005322	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
331272005323	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272005324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272005325	DNA binding site [nucleotide binding]
331272005326	domain linker motif; other site
331272005327	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
331272005328	putative ligand binding site [chemical binding]; other site
331272005329	putative dimerization interface [polypeptide binding]; other site
331272005330	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
331272005331	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
331272005332	dimerization interface [polypeptide binding]; other site
331272005333	ligand binding site [chemical binding]; other site
331272005334	NADP binding site [chemical binding]; other site
331272005335	catalytic site [active]
331272005336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272005337	D-galactonate transporter; Region: 2A0114; TIGR00893
331272005338	putative substrate translocation pore; other site
331272005339	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272005340	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
331272005341	substrate binding site [chemical binding]; other site
331272005342	ATP binding site [chemical binding]; other site
331272005343	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
331272005344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272005345	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
331272005346	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
331272005347	putative dimerization interface [polypeptide binding]; other site
331272005348	Predicted membrane protein [Function unknown]; Region: COG2855
331272005349	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
331272005350	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
331272005351	Cl- selectivity filter; other site
331272005352	Cl- binding residues [ion binding]; other site
331272005353	pore gating glutamate residue; other site
331272005354	dimer interface [polypeptide binding]; other site
331272005355	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
331272005356	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272005357	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272005358	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272005359	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272005360	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272005361	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272005362	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
331272005363	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331272005364	DNA binding residues [nucleotide binding]
331272005365	putative dimer interface [polypeptide binding]; other site
331272005366	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
331272005367	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
331272005368	PAS fold; Region: PAS_4; pfam08448
331272005369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272005370	putative active site [active]
331272005371	heme pocket [chemical binding]; other site
331272005372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005373	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
331272005374	Walker A motif; other site
331272005375	ATP binding site [chemical binding]; other site
331272005376	Walker B motif; other site
331272005377	arginine finger; other site
331272005378	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
331272005379	Putative phosphatase (DUF442); Region: DUF442; cl17385
331272005380	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
331272005381	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272005382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005383	dimer interface [polypeptide binding]; other site
331272005384	conserved gate region; other site
331272005385	putative PBP binding loops; other site
331272005386	ABC-ATPase subunit interface; other site
331272005387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272005388	dimer interface [polypeptide binding]; other site
331272005389	conserved gate region; other site
331272005390	putative PBP binding loops; other site
331272005391	ABC-ATPase subunit interface; other site
331272005392	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
331272005393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272005394	Walker A/P-loop; other site
331272005395	ATP binding site [chemical binding]; other site
331272005396	Q-loop/lid; other site
331272005397	ABC transporter signature motif; other site
331272005398	Walker B; other site
331272005399	D-loop; other site
331272005400	H-loop/switch region; other site
331272005401	TOBE domain; Region: TOBE_2; pfam08402
331272005402	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
331272005403	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272005404	Predicted Fe-S protein [General function prediction only]; Region: COG3313
331272005405	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
331272005406	putative fimbrial chaperone protein; Provisional; Region: PRK09918
331272005407	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
331272005408	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
331272005409	PapC N-terminal domain; Region: PapC_N; pfam13954
331272005410	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
331272005411	PapC C-terminal domain; Region: PapC_C; pfam13953
331272005412	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
331272005413	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
331272005414	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
331272005415	FMN binding site [chemical binding]; other site
331272005416	substrate binding site [chemical binding]; other site
331272005417	putative catalytic residue [active]
331272005418	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
331272005419	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272005420	NAD binding site [chemical binding]; other site
331272005421	catalytic residues [active]
331272005422	hypothetical protein; Provisional; Region: PRK11667
331272005423	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
331272005424	NodB motif; other site
331272005425	active site
331272005426	catalytic site [active]
331272005427	metal binding site [ion binding]; metal-binding site
331272005428	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
331272005429	Phosphotransferase enzyme family; Region: APH; pfam01636
331272005430	active site
331272005431	substrate binding site [chemical binding]; other site
331272005432	ATP binding site [chemical binding]; other site
331272005433	Cephalosporin hydroxylase; Region: CmcI; pfam04989
331272005434	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
331272005435	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
331272005436	active site
331272005437	TDP-binding site; other site
331272005438	acceptor substrate-binding pocket; other site
331272005439	homodimer interface [polypeptide binding]; other site
331272005440	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
331272005441	Asparagine synthase; Region: Asn_synthase; pfam00733
331272005442	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272005443	FeS/SAM binding site; other site
331272005444	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
331272005445	substrate binding site [chemical binding]; other site
331272005446	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
331272005447	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272005448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272005449	ABC transporter; Region: ABC_tran_2; pfam12848
331272005450	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272005451	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
331272005452	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
331272005453	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
331272005454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272005455	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
331272005456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272005457	Walker A/P-loop; other site
331272005458	Walker A/P-loop; other site
331272005459	ATP binding site [chemical binding]; other site
331272005460	Q-loop/lid; other site
331272005461	ABC transporter signature motif; other site
331272005462	Walker B; other site
331272005463	D-loop; other site
331272005464	H-loop/switch region; other site
331272005465	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
331272005466	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
331272005467	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
331272005468	putative NAD(P) binding site [chemical binding]; other site
331272005469	dimer interface [polypeptide binding]; other site
331272005470	transcriptional activator TtdR; Provisional; Region: PRK09801
331272005471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272005472	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272005473	putative effector binding pocket; other site
331272005474	dimerization interface [polypeptide binding]; other site
331272005475	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
331272005476	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
331272005477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272005478	motif II; other site
331272005479	cystathionine beta-lyase; Provisional; Region: PRK07050
331272005480	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272005481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272005482	catalytic residue [active]
331272005483	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
331272005484	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272005485	substrate binding site [chemical binding]; other site
331272005486	ATP binding site [chemical binding]; other site
331272005487	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
331272005488	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
331272005489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272005490	FeS/SAM binding site; other site
331272005491	TRAM domain; Region: TRAM; cl01282
331272005492	RibD C-terminal domain; Region: RibD_C; cl17279
331272005493	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
331272005494	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
331272005495	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
331272005496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
331272005497	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
331272005498	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
331272005499	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
331272005500	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
331272005501	NAD(P) binding site [chemical binding]; other site
331272005502	homotetramer interface [polypeptide binding]; other site
331272005503	homodimer interface [polypeptide binding]; other site
331272005504	active site
331272005505	putative acyltransferase; Provisional; Region: PRK05790
331272005506	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272005507	dimer interface [polypeptide binding]; other site
331272005508	active site
331272005509	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
331272005510	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
331272005511	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
331272005512	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
331272005513	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
331272005514	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272005515	RNA binding surface [nucleotide binding]; other site
331272005516	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
331272005517	active site
331272005518	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
331272005519	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
331272005520	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
331272005521	DEAD_2; Region: DEAD_2; pfam06733
331272005522	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
331272005523	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
331272005524	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
331272005525	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
331272005526	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
331272005527	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
331272005528	RNA binding site [nucleotide binding]; other site
331272005529	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
331272005530	potassium uptake protein; Region: kup; TIGR00794
331272005531	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
331272005532	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272005533	active site
331272005534	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
331272005535	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
331272005536	GDP-binding site [chemical binding]; other site
331272005537	ACT binding site; other site
331272005538	IMP binding site; other site
331272005539	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
331272005540	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
331272005541	dimer interface [polypeptide binding]; other site
331272005542	motif 1; other site
331272005543	active site
331272005544	motif 2; other site
331272005545	motif 3; other site
331272005546	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
331272005547	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
331272005548	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
331272005549	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
331272005550	HflK protein; Region: hflK; TIGR01933
331272005551	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
331272005552	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
331272005553	HflX GTPase family; Region: HflX; cd01878
331272005554	G1 box; other site
331272005555	GTP/Mg2+ binding site [chemical binding]; other site
331272005556	Switch I region; other site
331272005557	G2 box; other site
331272005558	G3 box; other site
331272005559	Switch II region; other site
331272005560	G4 box; other site
331272005561	G5 box; other site
331272005562	bacterial Hfq-like; Region: Hfq; cd01716
331272005563	hexamer interface [polypeptide binding]; other site
331272005564	Sm1 motif; other site
331272005565	RNA binding site [nucleotide binding]; other site
331272005566	Sm2 motif; other site
331272005567	GTP-binding protein Der; Reviewed; Region: PRK00093
331272005568	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
331272005569	G1 box; other site
331272005570	GTP/Mg2+ binding site [chemical binding]; other site
331272005571	Switch I region; other site
331272005572	G2 box; other site
331272005573	Switch II region; other site
331272005574	G3 box; other site
331272005575	G4 box; other site
331272005576	G5 box; other site
331272005577	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
331272005578	G1 box; other site
331272005579	GTP/Mg2+ binding site [chemical binding]; other site
331272005580	Switch I region; other site
331272005581	G2 box; other site
331272005582	G3 box; other site
331272005583	Switch II region; other site
331272005584	G4 box; other site
331272005585	G5 box; other site
331272005586	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
331272005587	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
331272005588	Trp docking motif [polypeptide binding]; other site
331272005589	active site
331272005590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
331272005591	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
331272005592	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
331272005593	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
331272005594	dimer interface [polypeptide binding]; other site
331272005595	motif 1; other site
331272005596	active site
331272005597	motif 2; other site
331272005598	motif 3; other site
331272005599	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
331272005600	anticodon binding site; other site
331272005601	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
331272005602	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
331272005603	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
331272005604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272005605	non-specific DNA binding site [nucleotide binding]; other site
331272005606	salt bridge; other site
331272005607	sequence-specific DNA binding site [nucleotide binding]; other site
331272005608	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
331272005609	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
331272005610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272005611	FeS/SAM binding site; other site
331272005612	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
331272005613	active site
331272005614	multimer interface [polypeptide binding]; other site
331272005615	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
331272005616	YccA-like proteins; Region: YccA_like; cd10433
331272005617	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
331272005618	TRAM domain; Region: TRAM; cl01282
331272005619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272005620	S-adenosylmethionine binding site [chemical binding]; other site
331272005621	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
331272005622	putative catalytic site [active]
331272005623	putative metal binding site [ion binding]; other site
331272005624	putative phosphate binding site [ion binding]; other site
331272005625	putative catalytic site [active]
331272005626	putative phosphate binding site [ion binding]; other site
331272005627	putative metal binding site [ion binding]; other site
331272005628	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
331272005629	active site
331272005630	catalytic site [active]
331272005631	substrate binding site [chemical binding]; other site
331272005632	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
331272005633	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
331272005634	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331272005635	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272005636	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272005637	DNA binding residues [nucleotide binding]
331272005638	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272005639	Peptidase family M23; Region: Peptidase_M23; pfam01551
331272005640	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
331272005641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272005642	S-adenosylmethionine binding site [chemical binding]; other site
331272005643	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
331272005644	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272005645	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272005646	recombination protein RecR; Reviewed; Region: recR; PRK00076
331272005647	RecR protein; Region: RecR; pfam02132
331272005648	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
331272005649	putative active site [active]
331272005650	putative metal-binding site [ion binding]; other site
331272005651	tetramer interface [polypeptide binding]; other site
331272005652	hypothetical protein; Validated; Region: PRK00153
331272005653	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
331272005654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005655	Walker A motif; other site
331272005656	ATP binding site [chemical binding]; other site
331272005657	Walker B motif; other site
331272005658	arginine finger; other site
331272005659	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
331272005660	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331272005661	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272005662	catalytic residues [active]
331272005663	transcription termination factor Rho; Provisional; Region: rho; PRK09376
331272005664	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
331272005665	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
331272005666	RNA binding site [nucleotide binding]; other site
331272005667	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
331272005668	multimer interface [polypeptide binding]; other site
331272005669	Walker A motif; other site
331272005670	ATP binding site [chemical binding]; other site
331272005671	Walker B motif; other site
331272005672	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331272005673	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
331272005674	DNA binding residues [nucleotide binding]
331272005675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272005676	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272005677	putative substrate translocation pore; other site
331272005678	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
331272005679	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
331272005680	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
331272005681	multidrug efflux protein; Reviewed; Region: PRK01766
331272005682	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
331272005683	cation binding site [ion binding]; other site
331272005684	lipoyl synthase; Provisional; Region: PRK12928
331272005685	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
331272005686	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272005687	E3 interaction surface; other site
331272005688	lipoyl attachment site [posttranslational modification]; other site
331272005689	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272005690	catalytic site [active]
331272005691	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
331272005692	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
331272005693	alpha subunit interface [polypeptide binding]; other site
331272005694	TPP binding site [chemical binding]; other site
331272005695	heterodimer interface [polypeptide binding]; other site
331272005696	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272005697	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
331272005698	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
331272005699	tetramer interface [polypeptide binding]; other site
331272005700	TPP-binding site [chemical binding]; other site
331272005701	heterodimer interface [polypeptide binding]; other site
331272005702	phosphorylation loop region [posttranslational modification]
331272005703	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
331272005704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272005705	NAD(P) binding site [chemical binding]; other site
331272005706	active site
331272005707	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
331272005708	ATP-NAD kinase; Region: NAD_kinase; pfam01513
331272005709	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
331272005710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005711	Walker A motif; other site
331272005712	ATP binding site [chemical binding]; other site
331272005713	Walker B motif; other site
331272005714	arginine finger; other site
331272005715	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272005716	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272005717	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
331272005718	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331272005719	DNA binding residues [nucleotide binding]
331272005720	putative dimer interface [polypeptide binding]; other site
331272005721	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
331272005722	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
331272005723	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
331272005724	Clp amino terminal domain; Region: Clp_N; pfam02861
331272005725	Clp amino terminal domain; Region: Clp_N; pfam02861
331272005726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005727	Walker A motif; other site
331272005728	ATP binding site [chemical binding]; other site
331272005729	Walker B motif; other site
331272005730	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
331272005731	arginine finger; other site
331272005732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005733	Walker A motif; other site
331272005734	ATP binding site [chemical binding]; other site
331272005735	Walker B motif; other site
331272005736	arginine finger; other site
331272005737	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
331272005738	Transcriptional regulator; Region: Rrf2; cl17282
331272005739	Rrf2 family protein; Region: rrf2_super; TIGR00738
331272005740	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
331272005741	apolar tunnel; other site
331272005742	heme binding site [chemical binding]; other site
331272005743	dimerization interface [polypeptide binding]; other site
331272005744	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
331272005745	MoaE homodimer interface [polypeptide binding]; other site
331272005746	MoaD interaction [polypeptide binding]; other site
331272005747	active site residues [active]
331272005748	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
331272005749	MoaE interaction surface [polypeptide binding]; other site
331272005750	MoeB interaction surface [polypeptide binding]; other site
331272005751	thiocarboxylated glycine; other site
331272005752	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
331272005753	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
331272005754	dimer interface [polypeptide binding]; other site
331272005755	putative functional site; other site
331272005756	putative MPT binding site; other site
331272005757	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
331272005758	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
331272005759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272005760	catalytic residue [active]
331272005761	homoserine dehydrogenase; Provisional; Region: PRK06349
331272005762	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
331272005763	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
331272005764	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
331272005765	aminotransferase AlaT; Validated; Region: PRK09265
331272005766	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272005767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272005768	homodimer interface [polypeptide binding]; other site
331272005769	catalytic residue [active]
331272005770	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
331272005771	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
331272005772	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
331272005773	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
331272005774	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
331272005775	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
331272005776	inhibitor-cofactor binding pocket; inhibition site
331272005777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272005778	catalytic residue [active]
331272005779	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
331272005780	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
331272005781	Ligand binding site; other site
331272005782	Putative Catalytic site; other site
331272005783	DXD motif; other site
331272005784	putative formyltransferase; Provisional; Region: PRK06988
331272005785	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
331272005786	active site
331272005787	substrate binding site [chemical binding]; other site
331272005788	cosubstrate binding site; other site
331272005789	catalytic site [active]
331272005790	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
331272005791	active site
331272005792	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
331272005793	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
331272005794	NAD binding site [chemical binding]; other site
331272005795	substrate binding site [chemical binding]; other site
331272005796	active site
331272005797	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
331272005798	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
331272005799	putative active site [active]
331272005800	putative catalytic site [active]
331272005801	putative Zn binding site [ion binding]; other site
331272005802	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
331272005803	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272005804	catalytic triad [active]
331272005805	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
331272005806	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
331272005807	putative active site [active]
331272005808	PhoH-like protein; Region: PhoH; pfam02562
331272005809	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
331272005810	NlpC/P60 family; Region: NLPC_P60; pfam00877
331272005811	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272005812	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272005813	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
331272005814	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
331272005815	replicative DNA helicase; Provisional; Region: PRK07004
331272005816	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
331272005817	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
331272005818	Walker A motif; other site
331272005819	ATP binding site [chemical binding]; other site
331272005820	Walker B motif; other site
331272005821	DNA binding loops [nucleotide binding]
331272005822	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
331272005823	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
331272005824	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
331272005825	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
331272005826	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
331272005827	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
331272005828	Putative zinc-finger; Region: zf-HC2; pfam13490
331272005829	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
331272005830	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
331272005831	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272005832	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272005833	DNA binding residues [nucleotide binding]
331272005834	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272005835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272005836	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272005837	putative effector binding pocket; other site
331272005838	dimerization interface [polypeptide binding]; other site
331272005839	glyoxylate carboligase; Provisional; Region: PRK11269
331272005840	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272005841	PYR/PP interface [polypeptide binding]; other site
331272005842	dimer interface [polypeptide binding]; other site
331272005843	TPP binding site [chemical binding]; other site
331272005844	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272005845	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
331272005846	TPP-binding site [chemical binding]; other site
331272005847	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
331272005848	tartronate semialdehyde reductase; Provisional; Region: PRK15059
331272005849	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272005850	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
331272005851	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272005852	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
331272005853	active site
331272005854	homodimer interface [polypeptide binding]; other site
331272005855	homotetramer interface [polypeptide binding]; other site
331272005856	psiF repeat; Region: PsiF_repeat; pfam07769
331272005857	psiF repeat; Region: PsiF_repeat; pfam07769
331272005858	Domain of unknown function DUF221; Region: DUF221; pfam02714
331272005859	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
331272005860	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
331272005861	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272005862	putative ADP-binding pocket [chemical binding]; other site
331272005863	Predicted ATPase [General function prediction only]; Region: COG4637
331272005864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272005865	Walker A/P-loop; other site
331272005866	ATP binding site [chemical binding]; other site
331272005867	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272005868	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272005869	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331272005870	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331272005871	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331272005872	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
331272005873	active site
331272005874	DNA polymerase III subunit delta'; Validated; Region: PRK06964
331272005875	DNA polymerase III subunit delta'; Validated; Region: PRK08485
331272005876	thymidylate kinase; Validated; Region: tmk; PRK00698
331272005877	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
331272005878	TMP-binding site; other site
331272005879	ATP-binding site [chemical binding]; other site
331272005880	YceG-like family; Region: YceG; pfam02618
331272005881	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
331272005882	dimerization interface [polypeptide binding]; other site
331272005883	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
331272005884	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
331272005885	NRDE protein; Region: NRDE; cl01315
331272005886	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272005887	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272005888	Coenzyme A binding pocket [chemical binding]; other site
331272005889	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272005890	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272005891	substrate binding pocket [chemical binding]; other site
331272005892	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
331272005893	CoenzymeA binding site [chemical binding]; other site
331272005894	subunit interaction site [polypeptide binding]; other site
331272005895	PHB binding site; other site
331272005896	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
331272005897	Cache domain; Region: Cache_1; pfam02743
331272005898	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272005899	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272005900	metal binding site [ion binding]; metal-binding site
331272005901	active site
331272005902	I-site; other site
331272005903	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272005904	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272005905	metal binding site [ion binding]; metal-binding site
331272005906	active site
331272005907	I-site; other site
331272005908	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
331272005909	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272005910	dimer interface [polypeptide binding]; other site
331272005911	active site
331272005912	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
331272005913	Isochorismatase family; Region: Isochorismatase; pfam00857
331272005914	catalytic triad [active]
331272005915	metal binding site [ion binding]; metal-binding site
331272005916	conserved cis-peptide bond; other site
331272005917	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272005918	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
331272005919	substrate binding site [chemical binding]; other site
331272005920	oxyanion hole (OAH) forming residues; other site
331272005921	trimer interface [polypeptide binding]; other site
331272005922	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272005923	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272005924	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272005925	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
331272005926	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
331272005927	dimer interface [polypeptide binding]; other site
331272005928	acyl-activating enzyme (AAE) consensus motif; other site
331272005929	putative active site [active]
331272005930	AMP binding site [chemical binding]; other site
331272005931	putative CoA binding site [chemical binding]; other site
331272005932	Uncharacterized conserved protein [Function unknown]; Region: COG0397
331272005933	hypothetical protein; Validated; Region: PRK00029
331272005934	methionine sulfoxide reductase B; Provisional; Region: PRK00222
331272005935	SelR domain; Region: SelR; pfam01641
331272005936	intracellular septation protein A; Reviewed; Region: PRK00259
331272005937	BolA-like protein; Region: BolA; pfam01722
331272005938	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
331272005939	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272005940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272005941	Coenzyme A binding pocket [chemical binding]; other site
331272005942	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
331272005943	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
331272005944	dimerization interface [polypeptide binding]; other site
331272005945	ATP binding site [chemical binding]; other site
331272005946	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
331272005947	dimerization interface [polypeptide binding]; other site
331272005948	ATP binding site [chemical binding]; other site
331272005949	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
331272005950	putative active site [active]
331272005951	catalytic triad [active]
331272005952	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
331272005953	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
331272005954	putative carbohydrate kinase; Provisional; Region: PRK10565
331272005955	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
331272005956	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
331272005957	putative substrate binding site [chemical binding]; other site
331272005958	putative ATP binding site [chemical binding]; other site
331272005959	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
331272005960	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
331272005961	active site
331272005962	dimer interface [polypeptide binding]; other site
331272005963	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
331272005964	dimer interface [polypeptide binding]; other site
331272005965	active site
331272005966	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331272005967	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
331272005968	Walker A/P-loop; other site
331272005969	ATP binding site [chemical binding]; other site
331272005970	Q-loop/lid; other site
331272005971	ABC transporter signature motif; other site
331272005972	Walker B; other site
331272005973	D-loop; other site
331272005974	H-loop/switch region; other site
331272005975	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
331272005976	active site
331272005977	catalytic triad [active]
331272005978	oxyanion hole [active]
331272005979	switch loop; other site
331272005980	SurA N-terminal domain; Region: SurA_N_3; cl07813
331272005981	periplasmic folding chaperone; Provisional; Region: PRK10788
331272005982	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
331272005983	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
331272005984	Found in ATP-dependent protease La (LON); Region: LON; smart00464
331272005985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005986	Walker A motif; other site
331272005987	ATP binding site [chemical binding]; other site
331272005988	Walker B motif; other site
331272005989	arginine finger; other site
331272005990	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
331272005991	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
331272005992	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
331272005993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272005994	Walker A motif; other site
331272005995	ATP binding site [chemical binding]; other site
331272005996	Walker B motif; other site
331272005997	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
331272005998	Clp protease; Region: CLP_protease; pfam00574
331272005999	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
331272006000	oligomer interface [polypeptide binding]; other site
331272006001	active site residues [active]
331272006002	trigger factor; Provisional; Region: tig; PRK01490
331272006003	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331272006004	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
331272006005	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
331272006006	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272006007	MarR family; Region: MarR_2; pfam12802
331272006008	MarR family; Region: MarR_2; cl17246
331272006009	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
331272006010	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272006011	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272006012	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272006013	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272006014	dimerization interface [polypeptide binding]; other site
331272006015	DNA binding residues [nucleotide binding]
331272006016	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272006017	trimer interface [polypeptide binding]; other site
331272006018	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272006019	eyelet of channel; other site
331272006020	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
331272006021	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
331272006022	active site
331272006023	Zn binding site [ion binding]; other site
331272006024	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
331272006025	active site lid residues [active]
331272006026	substrate binding pocket [chemical binding]; other site
331272006027	catalytic residues [active]
331272006028	substrate-Mg2+ binding site; other site
331272006029	aspartate-rich region 1; other site
331272006030	aspartate-rich region 2; other site
331272006031	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
331272006032	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
331272006033	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
331272006034	osmolarity response regulator; Provisional; Region: ompR; PRK09468
331272006035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272006036	active site
331272006037	phosphorylation site [posttranslational modification]
331272006038	intermolecular recognition site; other site
331272006039	dimerization interface [polypeptide binding]; other site
331272006040	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272006041	DNA binding site [nucleotide binding]
331272006042	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
331272006043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272006044	dimer interface [polypeptide binding]; other site
331272006045	phosphorylation site [posttranslational modification]
331272006046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272006047	ATP binding site [chemical binding]; other site
331272006048	Mg2+ binding site [ion binding]; other site
331272006049	G-X-G motif; other site
331272006050	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
331272006051	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
331272006052	dimer interface [polypeptide binding]; other site
331272006053	decamer (pentamer of dimers) interface [polypeptide binding]; other site
331272006054	catalytic triad [active]
331272006055	peroxidatic and resolving cysteines [active]
331272006056	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
331272006057	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272006058	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
331272006059	homotrimer interaction site [polypeptide binding]; other site
331272006060	zinc binding site [ion binding]; other site
331272006061	CDP-binding sites; other site
331272006062	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
331272006063	substrate binding site; other site
331272006064	dimer interface; other site
331272006065	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
331272006066	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
331272006067	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272006068	ATP binding site [chemical binding]; other site
331272006069	putative Mg++ binding site [ion binding]; other site
331272006070	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272006071	nucleotide binding region [chemical binding]; other site
331272006072	ATP-binding site [chemical binding]; other site
331272006073	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
331272006074	acetylornithine deacetylase; Provisional; Region: PRK07522
331272006075	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
331272006076	metal binding site [ion binding]; metal-binding site
331272006077	putative dimer interface [polypeptide binding]; other site
331272006078	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
331272006079	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
331272006080	tetramer interface [polypeptide binding]; other site
331272006081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272006082	catalytic residue [active]
331272006083	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
331272006084	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
331272006085	Transglycosylase; Region: Transgly; pfam00912
331272006086	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272006087	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
331272006088	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331272006089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
331272006090	TPR motif; other site
331272006091	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
331272006092	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
331272006093	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272006094	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272006095	Dodecin; Region: Dodecin; pfam07311
331272006096	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272006097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272006098	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
331272006099	putative substrate binding pocket [chemical binding]; other site
331272006100	putative dimerization interface [polypeptide binding]; other site
331272006101	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
331272006102	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
331272006103	active site
331272006104	putative substrate binding pocket [chemical binding]; other site
331272006105	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
331272006106	active site
331272006107	homotetramer interface [polypeptide binding]; other site
331272006108	Predicted membrane protein [Function unknown]; Region: COG3748
331272006109	Protein of unknown function (DUF989); Region: DUF989; pfam06181
331272006110	Cytochrome c; Region: Cytochrom_C; pfam00034
331272006111	ACT domain; Region: ACT_3; pfam10000
331272006112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
331272006113	ureidoglycolate hydrolase; Provisional; Region: PRK03606
331272006114	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
331272006115	allantoicase; Provisional; Region: PRK13257
331272006116	Allantoicase repeat; Region: Allantoicase; pfam03561
331272006117	Allantoicase repeat; Region: Allantoicase; pfam03561
331272006118	OHCU decarboxylase; Region: UHCUDC; TIGR03164
331272006119	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
331272006120	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
331272006121	active site
331272006122	catalytic site [active]
331272006123	tetramer interface [polypeptide binding]; other site
331272006124	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
331272006125	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
331272006126	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
331272006127	Na binding site [ion binding]; other site
331272006128	putative substrate binding site [chemical binding]; other site
331272006129	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272006130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272006131	DNA-binding site [nucleotide binding]; DNA binding site
331272006132	FCD domain; Region: FCD; pfam07729
331272006133	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
331272006134	dimer interface [polypeptide binding]; other site
331272006135	catalytic triad [active]
331272006136	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
331272006137	nucleoside/Zn binding site; other site
331272006138	dimer interface [polypeptide binding]; other site
331272006139	catalytic motif [active]
331272006140	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
331272006141	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272006142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272006143	putative substrate translocation pore; other site
331272006144	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
331272006145	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272006146	DNA-binding site [nucleotide binding]; DNA binding site
331272006147	UTRA domain; Region: UTRA; pfam07702
331272006148	putative oxidoreductase; Provisional; Region: PRK08275
331272006149	L-aspartate oxidase; Provisional; Region: PRK06175
331272006150	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
331272006151	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
331272006152	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
331272006153	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272006154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272006155	substrate binding pocket [chemical binding]; other site
331272006156	membrane-bound complex binding site; other site
331272006157	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272006158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272006159	dimer interface [polypeptide binding]; other site
331272006160	conserved gate region; other site
331272006161	putative PBP binding loops; other site
331272006162	ABC-ATPase subunit interface; other site
331272006163	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272006164	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272006165	Walker A/P-loop; other site
331272006166	ATP binding site [chemical binding]; other site
331272006167	Q-loop/lid; other site
331272006168	ABC transporter signature motif; other site
331272006169	Walker B; other site
331272006170	D-loop; other site
331272006171	H-loop/switch region; other site
331272006172	HEAT repeats; Region: HEAT_2; pfam13646
331272006173	HEAT repeats; Region: HEAT_2; pfam13646
331272006174	Protein of unknown function (DUF971); Region: DUF971; pfam06155
331272006175	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272006176	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272006177	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
331272006178	nudix motif; other site
331272006179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272006180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272006181	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272006182	Coenzyme A binding pocket [chemical binding]; other site
331272006183	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
331272006184	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331272006185	active site
331272006186	catalytic site [active]
331272006187	substrate binding site [chemical binding]; other site
331272006188	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272006189	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272006190	DNA-binding site [nucleotide binding]; DNA binding site
331272006191	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272006192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272006193	homodimer interface [polypeptide binding]; other site
331272006194	catalytic residue [active]
331272006195	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
331272006196	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272006197	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272006198	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
331272006199	DinB family; Region: DinB; cl17821
331272006200	DinB superfamily; Region: DinB_2; pfam12867
331272006201	GMP synthase; Reviewed; Region: guaA; PRK00074
331272006202	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
331272006203	AMP/PPi binding site [chemical binding]; other site
331272006204	candidate oxyanion hole; other site
331272006205	catalytic triad [active]
331272006206	potential glutamine specificity residues [chemical binding]; other site
331272006207	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
331272006208	ATP Binding subdomain [chemical binding]; other site
331272006209	Ligand Binding sites [chemical binding]; other site
331272006210	Dimerization subdomain; other site
331272006211	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
331272006212	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
331272006213	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
331272006214	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
331272006215	active site
331272006216	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
331272006217	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
331272006218	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
331272006219	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
331272006220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
331272006221	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
331272006222	putative coenzyme Q binding site [chemical binding]; other site
331272006223	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
331272006224	SmpB-tmRNA interface; other site
331272006225	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
331272006226	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
331272006227	phosphoenolpyruvate synthase; Validated; Region: PRK06464
331272006228	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
331272006229	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
331272006230	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
331272006231	PEP synthetase regulatory protein; Provisional; Region: PRK05339
331272006232	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
331272006233	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
331272006234	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
331272006235	RNA/DNA hybrid binding site [nucleotide binding]; other site
331272006236	active site
331272006237	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
331272006238	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
331272006239	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
331272006240	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
331272006241	active site
331272006242	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
331272006243	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
331272006244	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
331272006245	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
331272006246	trimer interface [polypeptide binding]; other site
331272006247	active site
331272006248	UDP-GlcNAc binding site [chemical binding]; other site
331272006249	lipid binding site [chemical binding]; lipid-binding site
331272006250	periplasmic chaperone; Provisional; Region: PRK10780
331272006251	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
331272006252	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
331272006253	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272006254	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272006255	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272006256	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272006257	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272006258	Surface antigen; Region: Bac_surface_Ag; pfam01103
331272006259	zinc metallopeptidase RseP; Provisional; Region: PRK10779
331272006260	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
331272006261	active site
331272006262	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
331272006263	protein binding site [polypeptide binding]; other site
331272006264	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
331272006265	putative substrate binding region [chemical binding]; other site
331272006266	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
331272006267	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
331272006268	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
331272006269	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
331272006270	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
331272006271	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
331272006272	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
331272006273	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
331272006274	catalytic residue [active]
331272006275	putative FPP diphosphate  binding site; other site
331272006276	putative FPP binding hydrophobic cleft; other site
331272006277	dimer interface [polypeptide binding]; other site
331272006278	putative IPP diphosphate binding site; other site
331272006279	ribosome recycling factor; Reviewed; Region: frr; PRK00083
331272006280	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
331272006281	hinge region; other site
331272006282	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
331272006283	putative nucleotide binding site [chemical binding]; other site
331272006284	uridine monophosphate binding site [chemical binding]; other site
331272006285	homohexameric interface [polypeptide binding]; other site
331272006286	elongation factor Ts; Provisional; Region: tsf; PRK09377
331272006287	UBA/TS-N domain; Region: UBA; pfam00627
331272006288	Elongation factor TS; Region: EF_TS; pfam00889
331272006289	Elongation factor TS; Region: EF_TS; pfam00889
331272006290	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
331272006291	rRNA interaction site [nucleotide binding]; other site
331272006292	S8 interaction site; other site
331272006293	putative laminin-1 binding site; other site
331272006294	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
331272006295	active site
331272006296	PII uridylyl-transferase; Provisional; Region: PRK03059
331272006297	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
331272006298	metal binding triad; other site
331272006299	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
331272006300	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272006301	Zn2+ binding site [ion binding]; other site
331272006302	Mg2+ binding site [ion binding]; other site
331272006303	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
331272006304	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
331272006305	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
331272006306	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
331272006307	RNA binding surface [nucleotide binding]; other site
331272006308	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
331272006309	active site
331272006310	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
331272006311	active site
331272006312	catalytic residues [active]
331272006313	metal binding site [ion binding]; metal-binding site
331272006314	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
331272006315	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
331272006316	nucleotide binding pocket [chemical binding]; other site
331272006317	K-X-D-G motif; other site
331272006318	catalytic site [active]
331272006319	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
331272006320	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
331272006321	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
331272006322	Dimer interface [polypeptide binding]; other site
331272006323	BRCT sequence motif; other site
331272006324	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
331272006325	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
331272006326	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
331272006327	Walker A/P-loop; other site
331272006328	ATP binding site [chemical binding]; other site
331272006329	Q-loop/lid; other site
331272006330	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
331272006331	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
331272006332	Q-loop/lid; other site
331272006333	ABC transporter signature motif; other site
331272006334	Walker B; other site
331272006335	D-loop; other site
331272006336	H-loop/switch region; other site
331272006337	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272006338	EamA-like transporter family; Region: EamA; pfam00892
331272006339	EamA-like transporter family; Region: EamA; pfam00892
331272006340	Probable transposase; Region: OrfB_IS605; pfam01385
331272006341	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272006342	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272006343	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
331272006344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272006345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272006346	homodimer interface [polypeptide binding]; other site
331272006347	catalytic residue [active]
331272006348	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
331272006349	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
331272006350	trimer interface [polypeptide binding]; other site
331272006351	active site
331272006352	substrate binding site [chemical binding]; other site
331272006353	CoA binding site [chemical binding]; other site
331272006354	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
331272006355	ArsC family; Region: ArsC; pfam03960
331272006356	putative catalytic residues [active]
331272006357	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
331272006358	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
331272006359	metal binding site [ion binding]; metal-binding site
331272006360	dimer interface [polypeptide binding]; other site
331272006361	HemK family putative methylases; Region: hemK_fam; TIGR00536
331272006362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272006363	S-adenosylmethionine binding site [chemical binding]; other site
331272006364	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
331272006365	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272006366	putative active site [active]
331272006367	catalytic site [active]
331272006368	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
331272006369	putative active site [active]
331272006370	catalytic site [active]
331272006371	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
331272006372	catalytic residues [active]
331272006373	dimer interface [polypeptide binding]; other site
331272006374	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
331272006375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272006376	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272006377	ABC transporter; Region: ABC_tran_2; pfam12848
331272006378	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272006379	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
331272006380	DNA repair protein RadA; Provisional; Region: PRK11823
331272006381	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
331272006382	Walker A motif/ATP binding site; other site
331272006383	ATP binding site [chemical binding]; other site
331272006384	Walker B motif; other site
331272006385	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
331272006386	alanine racemase; Reviewed; Region: dadX; PRK03646
331272006387	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
331272006388	active site
331272006389	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272006390	substrate binding site [chemical binding]; other site
331272006391	catalytic residues [active]
331272006392	dimer interface [polypeptide binding]; other site
331272006393	lysophospholipid transporter LplT; Provisional; Region: PRK11195
331272006394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272006395	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
331272006396	dimer interface [polypeptide binding]; other site
331272006397	substrate binding site [chemical binding]; other site
331272006398	ATP binding site [chemical binding]; other site
331272006399	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
331272006400	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
331272006401	Fe-S cluster binding site [ion binding]; other site
331272006402	active site
331272006403	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
331272006404	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272006405	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
331272006406	Glycoprotease family; Region: Peptidase_M22; pfam00814
331272006407	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
331272006408	acyl-CoA binding pocket [chemical binding]; other site
331272006409	CoA binding site [chemical binding]; other site
331272006410	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
331272006411	DEAD-like helicases superfamily; Region: DEXDc; smart00487
331272006412	ATP binding site [chemical binding]; other site
331272006413	Mg++ binding site [ion binding]; other site
331272006414	motif III; other site
331272006415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272006416	nucleotide binding region [chemical binding]; other site
331272006417	ATP-binding site [chemical binding]; other site
331272006418	isocitrate lyase; Provisional; Region: PRK15063
331272006419	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272006420	tetramer interface [polypeptide binding]; other site
331272006421	active site
331272006422	Mg2+/Mn2+ binding site [ion binding]; other site
331272006423	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272006424	Ligand Binding Site [chemical binding]; other site
331272006425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272006426	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272006427	putative effector binding pocket; other site
331272006428	dimerization interface [polypeptide binding]; other site
331272006429	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
331272006430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272006431	motif II; other site
331272006432	malate synthase A; Region: malate_syn_A; TIGR01344
331272006433	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
331272006434	active site
331272006435	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
331272006436	putative active site pocket [active]
331272006437	dimerization interface [polypeptide binding]; other site
331272006438	putative catalytic residue [active]
331272006439	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272006440	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272006441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272006442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272006443	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272006444	Coenzyme A binding pocket [chemical binding]; other site
331272006445	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
331272006446	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
331272006447	active site
331272006448	HIGH motif; other site
331272006449	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
331272006450	active site
331272006451	KMSKS motif; other site
331272006452	hypothetical protein; Provisional; Region: PRK10279
331272006453	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
331272006454	nucleophile elbow; other site
331272006455	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
331272006456	NlpC/P60 family; Region: NLPC_P60; pfam00877
331272006457	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
331272006458	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272006459	Walker A/P-loop; other site
331272006460	ATP binding site [chemical binding]; other site
331272006461	Q-loop/lid; other site
331272006462	ABC transporter signature motif; other site
331272006463	Walker B; other site
331272006464	D-loop; other site
331272006465	H-loop/switch region; other site
331272006466	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272006467	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272006468	Walker A/P-loop; other site
331272006469	ATP binding site [chemical binding]; other site
331272006470	Q-loop/lid; other site
331272006471	ABC transporter signature motif; other site
331272006472	Walker B; other site
331272006473	D-loop; other site
331272006474	H-loop/switch region; other site
331272006475	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272006476	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
331272006477	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
331272006478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272006479	dimer interface [polypeptide binding]; other site
331272006480	conserved gate region; other site
331272006481	putative PBP binding loops; other site
331272006482	ABC-ATPase subunit interface; other site
331272006483	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
331272006484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272006485	dimer interface [polypeptide binding]; other site
331272006486	conserved gate region; other site
331272006487	putative PBP binding loops; other site
331272006488	ABC-ATPase subunit interface; other site
331272006489	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
331272006490	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
331272006491	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
331272006492	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272006493	DNA binding site [nucleotide binding]
331272006494	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272006495	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272006496	dimerization interface [polypeptide binding]; other site
331272006497	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272006498	dimer interface [polypeptide binding]; other site
331272006499	phosphorylation site [posttranslational modification]
331272006500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272006501	ATP binding site [chemical binding]; other site
331272006502	Mg2+ binding site [ion binding]; other site
331272006503	G-X-G motif; other site
331272006504	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272006505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272006506	active site
331272006507	phosphorylation site [posttranslational modification]
331272006508	intermolecular recognition site; other site
331272006509	dimerization interface [polypeptide binding]; other site
331272006510	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272006511	DNA binding site [nucleotide binding]
331272006512	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272006513	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
331272006514	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
331272006515	Subunit I/III interface [polypeptide binding]; other site
331272006516	Subunit III/IV interface [polypeptide binding]; other site
331272006517	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
331272006518	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
331272006519	D-pathway; other site
331272006520	Putative ubiquinol binding site [chemical binding]; other site
331272006521	Low-spin heme (heme b) binding site [chemical binding]; other site
331272006522	Putative water exit pathway; other site
331272006523	Binuclear center (heme o3/CuB) [ion binding]; other site
331272006524	K-pathway; other site
331272006525	Putative proton exit pathway; other site
331272006526	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
331272006527	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
331272006528	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
331272006529	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
331272006530	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
331272006531	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
331272006532	aspartate kinase; Reviewed; Region: PRK06635
331272006533	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
331272006534	putative nucleotide binding site [chemical binding]; other site
331272006535	putative catalytic residues [active]
331272006536	putative Mg ion binding site [ion binding]; other site
331272006537	putative aspartate binding site [chemical binding]; other site
331272006538	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
331272006539	putative allosteric regulatory site; other site
331272006540	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
331272006541	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
331272006542	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
331272006543	Ligand Binding Site [chemical binding]; other site
331272006544	TilS substrate binding domain; Region: TilS; pfam09179
331272006545	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
331272006546	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
331272006547	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
331272006548	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331272006549	endonuclease III; Region: ENDO3c; smart00478
331272006550	minor groove reading motif; other site
331272006551	helix-hairpin-helix signature motif; other site
331272006552	substrate binding pocket [chemical binding]; other site
331272006553	active site
331272006554	Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215
331272006555	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
331272006556	active site
331272006557	HIGH motif; other site
331272006558	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
331272006559	KMSKS motif; other site
331272006560	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
331272006561	tRNA binding surface [nucleotide binding]; other site
331272006562	anticodon binding site; other site
331272006563	TPR repeat; Region: TPR_11; pfam13414
331272006564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272006565	binding surface
331272006566	TPR motif; other site
331272006567	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
331272006568	substrate binding site [chemical binding]; other site
331272006569	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
331272006570	substrate binding site [chemical binding]; other site
331272006571	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272006572	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
331272006573	putative active site [active]
331272006574	putative metal binding site [ion binding]; other site
331272006575	serine O-acetyltransferase; Region: cysE; TIGR01172
331272006576	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
331272006577	trimer interface [polypeptide binding]; other site
331272006578	active site
331272006579	substrate binding site [chemical binding]; other site
331272006580	CoA binding site [chemical binding]; other site
331272006581	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
331272006582	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
331272006583	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
331272006584	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
331272006585	active site
331272006586	dimerization interface [polypeptide binding]; other site
331272006587	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
331272006588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272006589	EthD domain; Region: EthD; cl17553
331272006590	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
331272006591	MutS domain I; Region: MutS_I; pfam01624
331272006592	MutS domain II; Region: MutS_II; pfam05188
331272006593	MutS domain III; Region: MutS_III; pfam05192
331272006594	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
331272006595	Walker A/P-loop; other site
331272006596	ATP binding site [chemical binding]; other site
331272006597	Q-loop/lid; other site
331272006598	ABC transporter signature motif; other site
331272006599	Walker B; other site
331272006600	D-loop; other site
331272006601	H-loop/switch region; other site
331272006602	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
331272006603	Cupin superfamily protein; Region: Cupin_4; pfam08007
331272006604	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
331272006605	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
331272006606	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
331272006607	dihydrodipicolinate synthase; Region: dapA; TIGR00674
331272006608	dimer interface [polypeptide binding]; other site
331272006609	active site
331272006610	catalytic residue [active]
331272006611	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
331272006612	active site
331272006613	HIGH motif; other site
331272006614	dimer interface [polypeptide binding]; other site
331272006615	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272006616	active site
331272006617	KMSKS motif; other site
331272006618	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
331272006619	Peptidase family M50; Region: Peptidase_M50; pfam02163
331272006620	active site
331272006621	putative substrate binding region [chemical binding]; other site
331272006622	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
331272006623	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
331272006624	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
331272006625	active site
331272006626	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
331272006627	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272006628	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272006629	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272006630	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
331272006631	dinuclear metal binding motif [ion binding]; other site
331272006632	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
331272006633	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
331272006634	trimer interface [polypeptide binding]; other site
331272006635	putative metal binding site [ion binding]; other site
331272006636	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
331272006637	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
331272006638	dimerization interface [polypeptide binding]; other site
331272006639	domain crossover interface; other site
331272006640	redox-dependent activation switch; other site
331272006641	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
331272006642	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
331272006643	enolase; Provisional; Region: eno; PRK00077
331272006644	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
331272006645	dimer interface [polypeptide binding]; other site
331272006646	metal binding site [ion binding]; metal-binding site
331272006647	substrate binding pocket [chemical binding]; other site
331272006648	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
331272006649	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
331272006650	CTP synthetase; Validated; Region: pyrG; PRK05380
331272006651	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
331272006652	Catalytic site [active]
331272006653	active site
331272006654	UTP binding site [chemical binding]; other site
331272006655	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
331272006656	active site
331272006657	putative oxyanion hole; other site
331272006658	catalytic triad [active]
331272006659	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
331272006660	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272006661	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
331272006662	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
331272006663	Competence protein; Region: Competence; pfam03772
331272006664	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
331272006665	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
331272006666	active site
331272006667	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
331272006668	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331272006669	Walker A/P-loop; other site
331272006670	ATP binding site [chemical binding]; other site
331272006671	Q-loop/lid; other site
331272006672	ABC transporter signature motif; other site
331272006673	Walker B; other site
331272006674	D-loop; other site
331272006675	H-loop/switch region; other site
331272006676	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
331272006677	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331272006678	FtsX-like permease family; Region: FtsX; pfam02687
331272006679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
331272006680	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
331272006681	DHH family; Region: DHH; pfam01368
331272006682	DHHA1 domain; Region: DHHA1; pfam02272
331272006683	peptide chain release factor 2; Validated; Region: prfB; PRK00578
331272006684	This domain is found in peptide chain release factors; Region: PCRF; smart00937
331272006685	RF-1 domain; Region: RF-1; pfam00472
331272006686	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
331272006687	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
331272006688	dimer interface [polypeptide binding]; other site
331272006689	putative anticodon binding site; other site
331272006690	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
331272006691	motif 1; other site
331272006692	active site
331272006693	motif 2; other site
331272006694	motif 3; other site
331272006695	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
331272006696	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
331272006697	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272006698	catalytic loop [active]
331272006699	iron binding site [ion binding]; other site
331272006700	chaperone protein HscA; Provisional; Region: hscA; PRK05183
331272006701	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
331272006702	nucleotide binding site [chemical binding]; other site
331272006703	putative NEF/HSP70 interaction site [polypeptide binding]; other site
331272006704	SBD interface [polypeptide binding]; other site
331272006705	co-chaperone HscB; Provisional; Region: hscB; PRK03578
331272006706	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
331272006707	HSP70 interaction site [polypeptide binding]; other site
331272006708	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
331272006709	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
331272006710	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
331272006711	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
331272006712	trimerization site [polypeptide binding]; other site
331272006713	active site
331272006714	cysteine desulfurase; Provisional; Region: PRK14012
331272006715	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
331272006716	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272006717	catalytic residue [active]
331272006718	Predicted transcriptional regulator [Transcription]; Region: COG1959
331272006719	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
331272006720	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
331272006721	Low molecular weight phosphatase family; Region: LMWPc; cd00115
331272006722	active site
331272006723	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
331272006724	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
331272006725	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
331272006726	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
331272006727	Cysteine-rich domain; Region: CCG; pfam02754
331272006728	Cysteine-rich domain; Region: CCG; pfam02754
331272006729	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272006730	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272006731	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272006732	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
331272006733	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
331272006734	Phasin protein; Region: Phasin_2; pfam09361
331272006735	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272006736	E3 interaction surface; other site
331272006737	lipoyl attachment site [posttranslational modification]; other site
331272006738	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
331272006739	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272006740	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272006741	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272006742	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
331272006743	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272006744	E3 interaction surface; other site
331272006745	lipoyl attachment site [posttranslational modification]; other site
331272006746	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272006747	E3 interaction surface; other site
331272006748	lipoyl attachment site [posttranslational modification]; other site
331272006749	e3 binding domain; Region: E3_binding; pfam02817
331272006750	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331272006751	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
331272006752	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
331272006753	dimer interface [polypeptide binding]; other site
331272006754	TPP-binding site [chemical binding]; other site
331272006755	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
331272006756	PAS domain S-box; Region: sensory_box; TIGR00229
331272006757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272006758	putative active site [active]
331272006759	heme pocket [chemical binding]; other site
331272006760	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272006761	dimer interface [polypeptide binding]; other site
331272006762	phosphorylation site [posttranslational modification]
331272006763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272006764	ATP binding site [chemical binding]; other site
331272006765	Mg2+ binding site [ion binding]; other site
331272006766	G-X-G motif; other site
331272006767	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
331272006768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272006769	active site
331272006770	phosphorylation site [posttranslational modification]
331272006771	intermolecular recognition site; other site
331272006772	dimerization interface [polypeptide binding]; other site
331272006773	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272006774	DNA binding residues [nucleotide binding]
331272006775	dimerization interface [polypeptide binding]; other site
331272006776	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
331272006777	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
331272006778	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
331272006779	homodimer interface [polypeptide binding]; other site
331272006780	NADP binding site [chemical binding]; other site
331272006781	substrate binding site [chemical binding]; other site
331272006782	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
331272006783	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
331272006784	active site
331272006785	Zn binding site [ion binding]; other site
331272006786	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
331272006787	active site
331272006788	DNA polymerase IV; Validated; Region: PRK02406
331272006789	DNA binding site [nucleotide binding]
331272006790	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
331272006791	aspartate racemase; Region: asp_race; TIGR00035
331272006792	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
331272006793	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
331272006794	putative catalytic site [active]
331272006795	putative phosphate binding site [ion binding]; other site
331272006796	active site
331272006797	metal binding site A [ion binding]; metal-binding site
331272006798	DNA binding site [nucleotide binding]
331272006799	putative AP binding site [nucleotide binding]; other site
331272006800	putative metal binding site B [ion binding]; other site
331272006801	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
331272006802	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272006803	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
331272006804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272006805	active site
331272006806	phosphorylation site [posttranslational modification]
331272006807	intermolecular recognition site; other site
331272006808	dimerization interface [polypeptide binding]; other site
331272006809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272006810	Walker A motif; other site
331272006811	ATP binding site [chemical binding]; other site
331272006812	Walker B motif; other site
331272006813	arginine finger; other site
331272006814	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272006815	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
331272006816	PAS domain; Region: PAS; smart00091
331272006817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272006818	dimer interface [polypeptide binding]; other site
331272006819	phosphorylation site [posttranslational modification]
331272006820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272006821	ATP binding site [chemical binding]; other site
331272006822	Mg2+ binding site [ion binding]; other site
331272006823	G-X-G motif; other site
331272006824	glutamine synthetase; Provisional; Region: glnA; PRK09469
331272006825	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
331272006826	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
331272006827	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
331272006828	active site residue [active]
331272006829	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
331272006830	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
331272006831	putative MPT binding site; other site
331272006832	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
331272006833	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
331272006834	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
331272006835	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
331272006836	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
331272006837	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
331272006838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272006839	ATP binding site [chemical binding]; other site
331272006840	putative Mg++ binding site [ion binding]; other site
331272006841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272006842	nucleotide binding region [chemical binding]; other site
331272006843	ATP-binding site [chemical binding]; other site
331272006844	Helicase associated domain (HA2); Region: HA2; pfam04408
331272006845	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
331272006846	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
331272006847	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
331272006848	N-acetylglutamate synthase; Validated; Region: PRK05279
331272006849	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
331272006850	putative feedback inhibition sensing region; other site
331272006851	putative nucleotide binding site [chemical binding]; other site
331272006852	putative substrate binding site [chemical binding]; other site
331272006853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272006854	Coenzyme A binding pocket [chemical binding]; other site
331272006855	oxidative damage protection protein; Provisional; Region: PRK05408
331272006856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272006857	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272006858	putative substrate translocation pore; other site
331272006859	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272006860	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272006861	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272006862	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272006863	active site
331272006864	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272006865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272006866	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272006867	dimerization interface [polypeptide binding]; other site
331272006868	putative aminotransferase; Validated; Region: PRK07480
331272006869	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272006870	inhibitor-cofactor binding pocket; inhibition site
331272006871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272006872	catalytic residue [active]
331272006873	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
331272006874	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
331272006875	Peptidase C26; Region: Peptidase_C26; pfam07722
331272006876	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
331272006877	catalytic triad [active]
331272006878	N-formylglutamate amidohydrolase; Region: FGase; cl01522
331272006879	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
331272006880	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
331272006881	active site
331272006882	imidazolonepropionase; Validated; Region: PRK09356
331272006883	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
331272006884	active site
331272006885	HutD; Region: HutD; pfam05962
331272006886	urocanate hydratase; Provisional; Region: PRK05414
331272006887	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
331272006888	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272006889	DNA-binding site [nucleotide binding]; DNA binding site
331272006890	UTRA domain; Region: UTRA; pfam07702
331272006891	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
331272006892	active sites [active]
331272006893	tetramer interface [polypeptide binding]; other site
331272006894	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272006895	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272006896	substrate binding pocket [chemical binding]; other site
331272006897	membrane-bound complex binding site; other site
331272006898	hinge residues; other site
331272006899	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
331272006900	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
331272006901	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
331272006902	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272006903	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
331272006904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272006905	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272006906	dimerization interface [polypeptide binding]; other site
331272006907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272006908	putative substrate translocation pore; other site
331272006909	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272006910	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
331272006911	DNA photolyase; Region: DNA_photolyase; pfam00875
331272006912	D-galactonate transporter; Region: 2A0114; TIGR00893
331272006913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272006914	putative substrate translocation pore; other site
331272006915	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
331272006916	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272006917	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272006918	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272006919	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272006920	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
331272006921	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
331272006922	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272006923	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272006924	N-terminal plug; other site
331272006925	ligand-binding site [chemical binding]; other site
331272006926	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
331272006927	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
331272006928	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
331272006929	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
331272006930	acetyl-CoA synthetase; Provisional; Region: PRK00174
331272006931	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
331272006932	active site
331272006933	CoA binding site [chemical binding]; other site
331272006934	acyl-activating enzyme (AAE) consensus motif; other site
331272006935	AMP binding site [chemical binding]; other site
331272006936	acetate binding site [chemical binding]; other site
331272006937	EamA-like transporter family; Region: EamA; pfam00892
331272006938	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272006939	EamA-like transporter family; Region: EamA; pfam00892
331272006940	hypothetical protein; Provisional; Region: PRK05208
331272006941	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
331272006942	Fumarase C-terminus; Region: Fumerase_C; pfam05683
331272006943	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
331272006944	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
331272006945	heme binding site [chemical binding]; other site
331272006946	ferroxidase pore; other site
331272006947	ferroxidase diiron center [ion binding]; other site
331272006948	glutamate racemase; Provisional; Region: PRK00865
331272006949	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
331272006950	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
331272006951	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
331272006952	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
331272006953	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272006954	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
331272006955	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272006956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272006957	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
331272006958	putative effector binding pocket; other site
331272006959	putative dimerization interface [polypeptide binding]; other site
331272006960	Pirin-related protein [General function prediction only]; Region: COG1741
331272006961	Pirin; Region: Pirin; pfam02678
331272006962	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
331272006963	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
331272006964	putative hydrophobic ligand binding site [chemical binding]; other site
331272006965	Hemin uptake protein hemP; Region: hemP; pfam10636
331272006966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272006967	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272006968	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272006969	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
331272006970	4Fe-4S binding domain; Region: Fer4_5; pfam12801
331272006971	Iron permease FTR1 family; Region: FTR1; cl00475
331272006972	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
331272006973	Fe2+ transport protein; Region: Iron_transport; pfam10634
331272006974	excinuclease ABC subunit B; Provisional; Region: PRK05298
331272006975	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
331272006976	ATP binding site [chemical binding]; other site
331272006977	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272006978	nucleotide binding region [chemical binding]; other site
331272006979	ATP-binding site [chemical binding]; other site
331272006980	Ultra-violet resistance protein B; Region: UvrB; pfam12344
331272006981	UvrB/uvrC motif; Region: UVR; pfam02151
331272006982	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
331272006983	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272006984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272006985	homodimer interface [polypeptide binding]; other site
331272006986	catalytic residue [active]
331272006987	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
331272006988	classical (c) SDRs; Region: SDR_c; cd05233
331272006989	NAD(P) binding site [chemical binding]; other site
331272006990	active site
331272006991	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
331272006992	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272006993	active site
331272006994	catalytic tetrad [active]
331272006995	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
331272006996	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
331272006997	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
331272006998	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
331272006999	DNA binding residues [nucleotide binding]
331272007000	dimer interface [polypeptide binding]; other site
331272007001	copper binding site [ion binding]; other site
331272007002	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
331272007003	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272007004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
331272007005	active site
331272007006	phosphorylation site [posttranslational modification]
331272007007	dimerization interface [polypeptide binding]; other site
331272007008	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272007009	DNA binding residues [nucleotide binding]
331272007010	Predicted membrane protein [Function unknown]; Region: COG3235
331272007011	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
331272007012	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
331272007013	putative active site [active]
331272007014	Zn binding site [ion binding]; other site
331272007015	hypothetical protein; Validated; Region: PRK02101
331272007016	PIN domain; Region: PIN_3; pfam13470
331272007017	methionine aminotransferase; Validated; Region: PRK09082
331272007018	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272007019	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272007020	homodimer interface [polypeptide binding]; other site
331272007021	catalytic residue [active]
331272007022	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272007023	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
331272007024	C-terminal domain interface [polypeptide binding]; other site
331272007025	GSH binding site (G-site) [chemical binding]; other site
331272007026	dimer interface [polypeptide binding]; other site
331272007027	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
331272007028	putative N-terminal domain interface [polypeptide binding]; other site
331272007029	putative dimer interface [polypeptide binding]; other site
331272007030	putative substrate binding pocket (H-site) [chemical binding]; other site
331272007031	enoyl-CoA hydratase; Provisional; Region: PRK07511
331272007032	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272007033	substrate binding site [chemical binding]; other site
331272007034	oxyanion hole (OAH) forming residues; other site
331272007035	trimer interface [polypeptide binding]; other site
331272007036	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
331272007037	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
331272007038	C-terminal domain interface [polypeptide binding]; other site
331272007039	GSH binding site (G-site) [chemical binding]; other site
331272007040	dimer interface [polypeptide binding]; other site
331272007041	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
331272007042	N-terminal domain interface [polypeptide binding]; other site
331272007043	putative dimer interface [polypeptide binding]; other site
331272007044	active site
331272007045	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
331272007046	putative active site [active]
331272007047	putative catalytic site [active]
331272007048	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
331272007049	putative active site [active]
331272007050	putative catalytic site [active]
331272007051	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
331272007052	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
331272007053	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
331272007054	active site
331272007055	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
331272007056	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
331272007057	FAD binding site [chemical binding]; other site
331272007058	substrate binding site [chemical binding]; other site
331272007059	catalytic base [active]
331272007060	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
331272007061	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
331272007062	dimer interface [polypeptide binding]; other site
331272007063	ADP-ribose binding site [chemical binding]; other site
331272007064	active site
331272007065	nudix motif; other site
331272007066	metal binding site [ion binding]; metal-binding site
331272007067	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
331272007068	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
331272007069	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
331272007070	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
331272007071	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
331272007072	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
331272007073	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
331272007074	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
331272007075	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
331272007076	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
331272007077	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
331272007078	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
331272007079	4Fe-4S binding domain; Region: Fer4; cl02805
331272007080	4Fe-4S binding domain; Region: Fer4; pfam00037
331272007081	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
331272007082	NADH dehydrogenase subunit G; Validated; Region: PRK09129
331272007083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272007084	catalytic loop [active]
331272007085	iron binding site [ion binding]; other site
331272007086	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
331272007087	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
331272007088	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
331272007089	SLBB domain; Region: SLBB; pfam10531
331272007090	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
331272007091	NADH dehydrogenase subunit E; Validated; Region: PRK07539
331272007092	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
331272007093	putative dimer interface [polypeptide binding]; other site
331272007094	[2Fe-2S] cluster binding site [ion binding]; other site
331272007095	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
331272007096	NADH dehydrogenase subunit D; Validated; Region: PRK06075
331272007097	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
331272007098	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
331272007099	NADH dehydrogenase subunit B; Validated; Region: PRK06411
331272007100	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
331272007101	Preprotein translocase SecG subunit; Region: SecG; pfam03840
331272007102	triosephosphate isomerase; Provisional; Region: PRK14567
331272007103	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
331272007104	substrate binding site [chemical binding]; other site
331272007105	dimer interface [polypeptide binding]; other site
331272007106	catalytic triad [active]
331272007107	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
331272007108	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
331272007109	NAD(P) binding site [chemical binding]; other site
331272007110	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
331272007111	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
331272007112	RNase E interface [polypeptide binding]; other site
331272007113	trimer interface [polypeptide binding]; other site
331272007114	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
331272007115	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
331272007116	RNase E interface [polypeptide binding]; other site
331272007117	trimer interface [polypeptide binding]; other site
331272007118	active site
331272007119	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
331272007120	putative nucleic acid binding region [nucleotide binding]; other site
331272007121	G-X-X-G motif; other site
331272007122	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
331272007123	RNA binding site [nucleotide binding]; other site
331272007124	domain interface; other site
331272007125	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
331272007126	16S/18S rRNA binding site [nucleotide binding]; other site
331272007127	S13e-L30e interaction site [polypeptide binding]; other site
331272007128	25S rRNA binding site [nucleotide binding]; other site
331272007129	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
331272007130	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
331272007131	putative ligand binding site [chemical binding]; other site
331272007132	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
331272007133	active site clefts [active]
331272007134	zinc binding site [ion binding]; other site
331272007135	dimer interface [polypeptide binding]; other site
331272007136	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
331272007137	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
331272007138	Sulfate transporter family; Region: Sulfate_transp; pfam00916
331272007139	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
331272007140	2-isopropylmalate synthase; Validated; Region: PRK00915
331272007141	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
331272007142	active site
331272007143	catalytic residues [active]
331272007144	metal binding site [ion binding]; metal-binding site
331272007145	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
331272007146	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
331272007147	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
331272007148	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
331272007149	ketol-acid reductoisomerase; Provisional; Region: PRK05479
331272007150	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
331272007151	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
331272007152	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
331272007153	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
331272007154	putative valine binding site [chemical binding]; other site
331272007155	dimer interface [polypeptide binding]; other site
331272007156	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
331272007157	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
331272007158	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272007159	PYR/PP interface [polypeptide binding]; other site
331272007160	dimer interface [polypeptide binding]; other site
331272007161	TPP binding site [chemical binding]; other site
331272007162	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272007163	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
331272007164	TPP-binding site [chemical binding]; other site
331272007165	dimer interface [polypeptide binding]; other site
331272007166	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272007167	RNA polymerase factor sigma-70; Validated; Region: PRK09047
331272007168	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272007169	DNA binding residues [nucleotide binding]
331272007170	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
331272007171	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
331272007172	RDD family; Region: RDD; pfam06271
331272007173	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
331272007174	putative active site [active]
331272007175	putative metal binding site [ion binding]; other site
331272007176	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272007177	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
331272007178	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
331272007179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272007180	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272007181	Bacterial transcriptional repressor; Region: TetR; pfam13972
331272007182	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
331272007183	glucose-1-dehydrogenase; Provisional; Region: PRK06947
331272007184	classical (c) SDRs; Region: SDR_c; cd05233
331272007185	NAD(P) binding site [chemical binding]; other site
331272007186	active site
331272007187	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
331272007188	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
331272007189	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
331272007190	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
331272007191	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
331272007192	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
331272007193	apolar tunnel; other site
331272007194	heme binding site [chemical binding]; other site
331272007195	dimerization interface [polypeptide binding]; other site
331272007196	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
331272007197	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
331272007198	multidrug efflux system protein; Provisional; Region: PRK11431
331272007199	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
331272007200	Domain of unknown function (DUF333); Region: DUF333; pfam03891
331272007201	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
331272007202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272007203	active site
331272007204	phosphorylation site [posttranslational modification]
331272007205	intermolecular recognition site; other site
331272007206	dimerization interface [polypeptide binding]; other site
331272007207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272007208	DNA binding site [nucleotide binding]
331272007209	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
331272007210	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
331272007211	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
331272007212	Ligand Binding Site [chemical binding]; other site
331272007213	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
331272007214	GAF domain; Region: GAF_3; pfam13492
331272007215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272007216	dimer interface [polypeptide binding]; other site
331272007217	phosphorylation site [posttranslational modification]
331272007218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272007219	ATP binding site [chemical binding]; other site
331272007220	Mg2+ binding site [ion binding]; other site
331272007221	G-X-G motif; other site
331272007222	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
331272007223	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
331272007224	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331272007225	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
331272007226	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
331272007227	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
331272007228	NADP binding site [chemical binding]; other site
331272007229	dimer interface [polypeptide binding]; other site
331272007230	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
331272007231	substrate binding site [chemical binding]; other site
331272007232	short chain dehydrogenase; Provisional; Region: PRK08339
331272007233	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
331272007234	putative NAD(P) binding site [chemical binding]; other site
331272007235	putative active site [active]
331272007236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272007237	active site
331272007238	hypothetical protein; Validated; Region: PRK00110
331272007239	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
331272007240	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
331272007241	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
331272007242	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
331272007243	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
331272007244	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
331272007245	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
331272007246	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
331272007247	active site
331272007248	(T/H)XGH motif; other site
331272007249	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
331272007250	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
331272007251	Maf-like protein; Region: Maf; pfam02545
331272007252	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
331272007253	active site
331272007254	dimer interface [polypeptide binding]; other site
331272007255	ribonuclease G; Provisional; Region: PRK11712
331272007256	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
331272007257	homodimer interface [polypeptide binding]; other site
331272007258	oligonucleotide binding site [chemical binding]; other site
331272007259	Protein with unknown function (DUF469); Region: DUF469; pfam04320
331272007260	PRC-barrel domain; Region: PRC; pfam05239
331272007261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272007262	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272007263	putative substrate translocation pore; other site
331272007264	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
331272007265	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
331272007266	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272007267	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
331272007268	Walker A/P-loop; other site
331272007269	ATP binding site [chemical binding]; other site
331272007270	Q-loop/lid; other site
331272007271	ABC transporter signature motif; other site
331272007272	Walker B; other site
331272007273	D-loop; other site
331272007274	H-loop/switch region; other site
331272007275	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
331272007276	putative metal binding site; other site
331272007277	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
331272007278	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
331272007279	active site
331272007280	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
331272007281	O-Antigen ligase; Region: Wzy_C; pfam04932
331272007282	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272007283	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272007284	putative active site [active]
331272007285	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272007286	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272007287	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272007288	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
331272007289	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
331272007290	putative active site [active]
331272007291	putative PHP Thumb interface [polypeptide binding]; other site
331272007292	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
331272007293	generic binding surface II; other site
331272007294	generic binding surface I; other site
331272007295	rhodanese superfamily protein; Provisional; Region: PRK05320
331272007296	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
331272007297	active site residue [active]
331272007298	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
331272007299	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
331272007300	active site
331272007301	HIGH motif; other site
331272007302	nucleotide binding site [chemical binding]; other site
331272007303	active site
331272007304	KMSKS motif; other site
331272007305	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
331272007306	DEAD-like helicases superfamily; Region: DEXDc; smart00487
331272007307	ATP binding site [chemical binding]; other site
331272007308	Mg++ binding site [ion binding]; other site
331272007309	motif III; other site
331272007310	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272007311	nucleotide binding region [chemical binding]; other site
331272007312	ATP-binding site [chemical binding]; other site
331272007313	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
331272007314	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
331272007315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272007316	ATP-grasp domain; Region: ATP-grasp; pfam02222
331272007317	META domain; Region: META; pfam03724
331272007318	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
331272007319	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
331272007320	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
331272007321	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
331272007322	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
331272007323	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
331272007324	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
331272007325	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
331272007326	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272007327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272007328	ferredoxin; Provisional; Region: PRK08764
331272007329	Putative Fe-S cluster; Region: FeS; pfam04060
331272007330	4Fe-4S binding domain; Region: Fer4; pfam00037
331272007331	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
331272007332	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331272007333	minor groove reading motif; other site
331272007334	helix-hairpin-helix signature motif; other site
331272007335	substrate binding pocket [chemical binding]; other site
331272007336	active site
331272007337	EamA-like transporter family; Region: EamA; pfam00892
331272007338	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272007339	EamA-like transporter family; Region: EamA; pfam00892
331272007340	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
331272007341	Cytochrome c553 [Energy production and conversion]; Region: COG2863
331272007342	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272007343	Cytochrome c553 [Energy production and conversion]; Region: COG2863
331272007344	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
331272007345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272007346	Walker A motif; other site
331272007347	ATP binding site [chemical binding]; other site
331272007348	Walker B motif; other site
331272007349	arginine finger; other site
331272007350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
331272007351	Benzoate membrane transport protein; Region: BenE; pfam03594
331272007352	benzoate transporter; Region: benE; TIGR00843
331272007353	transaldolase-like protein; Provisional; Region: PTZ00411
331272007354	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
331272007355	active site
331272007356	dimer interface [polypeptide binding]; other site
331272007357	catalytic residue [active]
331272007358	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
331272007359	dimer interface [polypeptide binding]; other site
331272007360	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272007361	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
331272007362	Na binding site [ion binding]; other site
331272007363	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
331272007364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331272007365	conjugal transfer protein TraL; Provisional; Region: PRK13886
331272007366	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272007367	putative Zn2+ binding site [ion binding]; other site
331272007368	putative DNA binding site [nucleotide binding]; other site
331272007369	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
331272007370	active site
331272007371	NTP binding site [chemical binding]; other site
331272007372	metal binding triad [ion binding]; metal-binding site
331272007373	antibiotic binding site [chemical binding]; other site
331272007374	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
331272007375	putative active site [active]
331272007376	Chorismate lyase; Region: Chor_lyase; cl01230
331272007377	heat shock protein 90; Provisional; Region: PRK05218
331272007378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272007379	ATP binding site [chemical binding]; other site
331272007380	Mg2+ binding site [ion binding]; other site
331272007381	G-X-G motif; other site
331272007382	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272007383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272007384	DNA-binding site [nucleotide binding]; DNA binding site
331272007385	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272007386	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272007387	homodimer interface [polypeptide binding]; other site
331272007388	catalytic residue [active]
331272007389	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
331272007390	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272007391	EamA-like transporter family; Region: EamA; pfam00892
331272007392	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
331272007393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272007394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272007395	homodimer interface [polypeptide binding]; other site
331272007396	catalytic residue [active]
331272007397	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
331272007398	homotrimer interaction site [polypeptide binding]; other site
331272007399	putative active site [active]
331272007400	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
331272007401	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
331272007402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272007403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272007404	metal binding site [ion binding]; metal-binding site
331272007405	active site
331272007406	I-site; other site
331272007407	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272007408	Chromate transporter; Region: Chromate_transp; pfam02417
331272007409	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
331272007410	Chromate transporter; Region: Chromate_transp; pfam02417
331272007411	Predicted membrane protein [Function unknown]; Region: COG4125
331272007412	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272007413	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272007414	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272007415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007416	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272007417	dimerization interface [polypeptide binding]; other site
331272007418	Copper resistance protein D; Region: CopD; cl00563
331272007419	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
331272007420	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
331272007421	CAP-like domain; other site
331272007422	active site
331272007423	primary dimer interface [polypeptide binding]; other site
331272007424	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
331272007425	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
331272007426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272007427	ATP binding site [chemical binding]; other site
331272007428	Mg2+ binding site [ion binding]; other site
331272007429	G-X-G motif; other site
331272007430	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
331272007431	anchoring element; other site
331272007432	dimer interface [polypeptide binding]; other site
331272007433	ATP binding site [chemical binding]; other site
331272007434	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
331272007435	active site
331272007436	metal binding site [ion binding]; metal-binding site
331272007437	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
331272007438	ABC transporter ATPase component; Reviewed; Region: PRK11147
331272007439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272007440	Walker A/P-loop; other site
331272007441	ATP binding site [chemical binding]; other site
331272007442	Q-loop/lid; other site
331272007443	ABC transporter signature motif; other site
331272007444	Walker B; other site
331272007445	D-loop; other site
331272007446	H-loop/switch region; other site
331272007447	ABC transporter; Region: ABC_tran_2; pfam12848
331272007448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272007449	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
331272007450	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
331272007451	Rubredoxin; Region: Rubredoxin; pfam00301
331272007452	iron binding site [ion binding]; other site
331272007453	integrase; Provisional; Region: PRK09692
331272007454	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
331272007455	active site
331272007456	Int/Topo IB signature motif; other site
331272007457	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
331272007458	Domain of unknown function (DUF927); Region: DUF927; pfam06048
331272007459	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
331272007460	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
331272007461	ATP binding site [chemical binding]; other site
331272007462	Mg2+ binding site [ion binding]; other site
331272007463	G-X-G motif; other site
331272007464	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
331272007465	anti sigma factor interaction site; other site
331272007466	regulatory phosphorylation site [posttranslational modification]; other site
331272007467	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
331272007468	multiple promoter invertase; Provisional; Region: mpi; PRK13413
331272007469	catalytic residues [active]
331272007470	catalytic nucleophile [active]
331272007471	Presynaptic Site I dimer interface [polypeptide binding]; other site
331272007472	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
331272007473	Synaptic Flat tetramer interface [polypeptide binding]; other site
331272007474	Synaptic Site I dimer interface [polypeptide binding]; other site
331272007475	DNA binding site [nucleotide binding]
331272007476	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331272007477	DNA-binding interface [nucleotide binding]; DNA binding site
331272007478	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
331272007479	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
331272007480	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
331272007481	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
331272007482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272007483	S-adenosylmethionine binding site [chemical binding]; other site
331272007484	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
331272007485	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
331272007486	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272007487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272007488	DNA binding residues [nucleotide binding]
331272007489	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
331272007490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272007491	NAD(P) binding site [chemical binding]; other site
331272007492	active site
331272007493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272007494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272007495	ecotin; Provisional; Region: PRK03719
331272007496	secondary substrate binding site; other site
331272007497	primary substrate binding site; other site
331272007498	inhibition loop; other site
331272007499	dimerization interface [polypeptide binding]; other site
331272007500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272007501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272007502	putative substrate translocation pore; other site
331272007503	Predicted ATPase [General function prediction only]; Region: COG3911
331272007504	AAA domain; Region: AAA_28; pfam13521
331272007505	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
331272007506	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
331272007507	active site
331272007508	homotetramer interface [polypeptide binding]; other site
331272007509	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272007510	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272007511	Walker A/P-loop; other site
331272007512	ATP binding site [chemical binding]; other site
331272007513	Q-loop/lid; other site
331272007514	ABC transporter signature motif; other site
331272007515	Walker B; other site
331272007516	D-loop; other site
331272007517	H-loop/switch region; other site
331272007518	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
331272007519	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
331272007520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272007521	dimer interface [polypeptide binding]; other site
331272007522	conserved gate region; other site
331272007523	putative PBP binding loops; other site
331272007524	ABC-ATPase subunit interface; other site
331272007525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272007526	dimer interface [polypeptide binding]; other site
331272007527	conserved gate region; other site
331272007528	putative PBP binding loops; other site
331272007529	ABC-ATPase subunit interface; other site
331272007530	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
331272007531	HAMP domain; Region: HAMP; pfam00672
331272007532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272007533	dimer interface [polypeptide binding]; other site
331272007534	phosphorylation site [posttranslational modification]
331272007535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272007536	ATP binding site [chemical binding]; other site
331272007537	Mg2+ binding site [ion binding]; other site
331272007538	G-X-G motif; other site
331272007539	osmolarity response regulator; Provisional; Region: ompR; PRK09468
331272007540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272007541	active site
331272007542	phosphorylation site [posttranslational modification]
331272007543	intermolecular recognition site; other site
331272007544	dimerization interface [polypeptide binding]; other site
331272007545	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272007546	DNA binding site [nucleotide binding]
331272007547	Heavy-metal resistance; Region: Metal_resist; pfam13801
331272007548	Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824
331272007549	Pirin-related protein [General function prediction only]; Region: COG1741
331272007550	Pirin; Region: Pirin; pfam02678
331272007551	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272007552	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272007553	substrate binding pocket [chemical binding]; other site
331272007554	membrane-bound complex binding site; other site
331272007555	hinge residues; other site
331272007556	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272007557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272007558	dimer interface [polypeptide binding]; other site
331272007559	conserved gate region; other site
331272007560	putative PBP binding loops; other site
331272007561	ABC-ATPase subunit interface; other site
331272007562	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272007563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272007564	dimer interface [polypeptide binding]; other site
331272007565	conserved gate region; other site
331272007566	putative PBP binding loops; other site
331272007567	ABC-ATPase subunit interface; other site
331272007568	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
331272007569	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272007570	Walker A/P-loop; other site
331272007571	ATP binding site [chemical binding]; other site
331272007572	Q-loop/lid; other site
331272007573	ABC transporter signature motif; other site
331272007574	Walker B; other site
331272007575	D-loop; other site
331272007576	H-loop/switch region; other site
331272007577	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272007578	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272007579	The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468
331272007580	putative substrate binding pocket [chemical binding]; other site
331272007581	dimerization interface [polypeptide binding]; other site
331272007582	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272007583	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272007584	trimer interface [polypeptide binding]; other site
331272007585	eyelet of channel; other site
331272007586	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
331272007587	Nitrogen regulatory protein P-II; Region: P-II; smart00938
331272007588	NAD synthetase; Provisional; Region: PRK13981
331272007589	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
331272007590	multimer interface [polypeptide binding]; other site
331272007591	active site
331272007592	catalytic triad [active]
331272007593	protein interface 1 [polypeptide binding]; other site
331272007594	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
331272007595	homodimer interface [polypeptide binding]; other site
331272007596	NAD binding pocket [chemical binding]; other site
331272007597	ATP binding pocket [chemical binding]; other site
331272007598	Mg binding site [ion binding]; other site
331272007599	active-site loop [active]
331272007600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
331272007601	Protein of unknown function, DUF482; Region: DUF482; pfam04339
331272007602	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
331272007603	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
331272007604	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
331272007605	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
331272007606	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272007607	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272007608	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
331272007609	GIY-YIG motif/motif A; other site
331272007610	putative active site [active]
331272007611	putative metal binding site [ion binding]; other site
331272007612	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
331272007613	dimer interface [polypeptide binding]; other site
331272007614	substrate binding site [chemical binding]; other site
331272007615	metal binding sites [ion binding]; metal-binding site
331272007616	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272007617	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
331272007618	NAD(P) binding site [chemical binding]; other site
331272007619	catalytic residues [active]
331272007620	catalytic residues [active]
331272007621	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
331272007622	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
331272007623	putative NAD(P) binding site [chemical binding]; other site
331272007624	active site
331272007625	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272007626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272007627	putative substrate translocation pore; other site
331272007628	Helix-turn-helix domain; Region: HTH_17; pfam12728
331272007629	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272007630	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
331272007631	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
331272007632	HemY protein N-terminus; Region: HemY_N; pfam07219
331272007633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272007634	TPR motif; other site
331272007635	binding surface
331272007636	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
331272007637	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
331272007638	active site
331272007639	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
331272007640	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
331272007641	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
331272007642	domain interfaces; other site
331272007643	active site
331272007644	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
331272007645	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
331272007646	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272007647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272007648	S-adenosylmethionine binding site [chemical binding]; other site
331272007649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272007650	non-specific DNA binding site [nucleotide binding]; other site
331272007651	salt bridge; other site
331272007652	sequence-specific DNA binding site [nucleotide binding]; other site
331272007653	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272007654	argininosuccinate lyase; Provisional; Region: PRK00855
331272007655	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
331272007656	active sites [active]
331272007657	tetramer interface [polypeptide binding]; other site
331272007658	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
331272007659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272007660	motif II; other site
331272007661	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
331272007662	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
331272007663	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
331272007664	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
331272007665	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272007666	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272007667	catalytic residue [active]
331272007668	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
331272007669	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
331272007670	trimer interface [polypeptide binding]; other site
331272007671	active site
331272007672	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
331272007673	E-class dimer interface [polypeptide binding]; other site
331272007674	P-class dimer interface [polypeptide binding]; other site
331272007675	active site
331272007676	Cu2+ binding site [ion binding]; other site
331272007677	Zn2+ binding site [ion binding]; other site
331272007678	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
331272007679	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272007680	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272007681	ligand binding site [chemical binding]; other site
331272007682	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
331272007683	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
331272007684	active site
331272007685	HIGH motif; other site
331272007686	KMSKS motif; other site
331272007687	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
331272007688	tRNA binding surface [nucleotide binding]; other site
331272007689	anticodon binding site; other site
331272007690	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
331272007691	dimer interface [polypeptide binding]; other site
331272007692	putative tRNA-binding site [nucleotide binding]; other site
331272007693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
331272007694	Family of unknown function (DUF490); Region: DUF490; pfam04357
331272007695	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
331272007696	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272007697	Surface antigen; Region: Bac_surface_Ag; pfam01103
331272007698	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
331272007699	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
331272007700	pantoate--beta-alanine ligase; Region: panC; TIGR00018
331272007701	Pantoate-beta-alanine ligase; Region: PanC; cd00560
331272007702	active site
331272007703	ATP-binding site [chemical binding]; other site
331272007704	pantoate-binding site; other site
331272007705	HXXH motif; other site
331272007706	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
331272007707	tetramerization interface [polypeptide binding]; other site
331272007708	active site
331272007709	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331272007710	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272007711	P-loop; other site
331272007712	Magnesium ion binding site [ion binding]; other site
331272007713	DoxX; Region: DoxX; pfam07681
331272007714	cobyric acid synthase; Provisional; Region: PRK00784
331272007715	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331272007716	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
331272007717	catalytic triad [active]
331272007718	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
331272007719	homotrimer interface [polypeptide binding]; other site
331272007720	Walker A motif; other site
331272007721	GTP binding site [chemical binding]; other site
331272007722	Walker B motif; other site
331272007723	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
331272007724	putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959
331272007725	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
331272007726	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272007727	catalytic residue [active]
331272007728	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
331272007729	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
331272007730	cobalamin binding residues [chemical binding]; other site
331272007731	putative BtuC binding residues; other site
331272007732	dimer interface [polypeptide binding]; other site
331272007733	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272007734	catalytic core [active]
331272007735	cobalamin synthase; Reviewed; Region: cobS; PRK00235
331272007736	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
331272007737	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
331272007738	putative dimer interface [polypeptide binding]; other site
331272007739	active site pocket [active]
331272007740	putative cataytic base [active]
331272007741	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
331272007742	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
331272007743	Walker A/P-loop; other site
331272007744	ATP binding site [chemical binding]; other site
331272007745	Q-loop/lid; other site
331272007746	ABC transporter signature motif; other site
331272007747	Walker B; other site
331272007748	D-loop; other site
331272007749	H-loop/switch region; other site
331272007750	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
331272007751	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
331272007752	ABC-ATPase subunit  interface; other site
331272007753	dimer interface [polypeptide binding]; other site
331272007754	putative PBP binding regions; other site
331272007755	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
331272007756	Cell division protein ZapA; Region: ZapA; pfam05164
331272007757	EVE domain; Region: EVE; cl00728
331272007758	Protein of unknown function (DUF541); Region: SIMPL; cl01077
331272007759	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
331272007760	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
331272007761	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007762	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
331272007763	putative dimerization interface [polypeptide binding]; other site
331272007764	putative substrate binding pocket [chemical binding]; other site
331272007765	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
331272007766	Cytochrome c; Region: Cytochrom_C; cl11414
331272007767	Protein of unknown function (DUF2486); Region: DUF2486; pfam10667
331272007768	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
331272007769	multifunctional aminopeptidase A; Provisional; Region: PRK00913
331272007770	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
331272007771	interface (dimer of trimers) [polypeptide binding]; other site
331272007772	Substrate-binding/catalytic site; other site
331272007773	Zn-binding sites [ion binding]; other site
331272007774	Predicted permeases [General function prediction only]; Region: COG0795
331272007775	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
331272007776	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
331272007777	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
331272007778	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
331272007779	putative active site [active]
331272007780	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
331272007781	active site
331272007782	SAM binding site [chemical binding]; other site
331272007783	homodimer interface [polypeptide binding]; other site
331272007784	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
331272007785	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
331272007786	CysD dimerization site [polypeptide binding]; other site
331272007787	G1 box; other site
331272007788	putative GEF interaction site [polypeptide binding]; other site
331272007789	GTP/Mg2+ binding site [chemical binding]; other site
331272007790	Switch I region; other site
331272007791	G2 box; other site
331272007792	G3 box; other site
331272007793	Switch II region; other site
331272007794	G4 box; other site
331272007795	G5 box; other site
331272007796	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
331272007797	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
331272007798	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
331272007799	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
331272007800	Active Sites [active]
331272007801	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
331272007802	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
331272007803	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
331272007804	Active Sites [active]
331272007805	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
331272007806	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
331272007807	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
331272007808	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
331272007809	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
331272007810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007811	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
331272007812	substrate binding site [chemical binding]; other site
331272007813	dimerization interface [polypeptide binding]; other site
331272007814	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272007815	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
331272007816	putative ligand binding site [chemical binding]; other site
331272007817	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272007818	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007819	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272007820	putative effector binding pocket; other site
331272007821	dimerization interface [polypeptide binding]; other site
331272007822	short chain dehydrogenase; Provisional; Region: PRK12937
331272007823	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
331272007824	NADP binding site [chemical binding]; other site
331272007825	homodimer interface [polypeptide binding]; other site
331272007826	active site
331272007827	substrate binding site [chemical binding]; other site
331272007828	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272007829	NADP binding site [chemical binding]; other site
331272007830	active site
331272007831	steroid binding site; other site
331272007832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272007833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007834	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272007835	dimerization interface [polypeptide binding]; other site
331272007836	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272007837	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272007838	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272007839	putative effector binding pocket; other site
331272007840	putative dimerization interface [polypeptide binding]; other site
331272007841	short chain dehydrogenase; Provisional; Region: PRK12744
331272007842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272007843	NAD(P) binding site [chemical binding]; other site
331272007844	active site
331272007845	DinB superfamily; Region: DinB_2; pfam12867
331272007846	CopC domain; Region: CopC; pfam04234
331272007847	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
331272007848	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
331272007849	active site
331272007850	uracil binding [chemical binding]; other site
331272007851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272007852	NAD(P) binding site [chemical binding]; other site
331272007853	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272007854	active site
331272007855	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
331272007856	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272007857	catalytic loop [active]
331272007858	iron binding site [ion binding]; other site
331272007859	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
331272007860	FAD binding pocket [chemical binding]; other site
331272007861	FAD binding motif [chemical binding]; other site
331272007862	phosphate binding motif [ion binding]; other site
331272007863	beta-alpha-beta structure motif; other site
331272007864	NAD binding pocket [chemical binding]; other site
331272007865	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
331272007866	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272007867	inhibitor-cofactor binding pocket; inhibition site
331272007868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272007869	catalytic residue [active]
331272007870	putative acetyltransferase; Provisional; Region: PRK03624
331272007871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272007872	Coenzyme A binding pocket [chemical binding]; other site
331272007873	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
331272007874	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272007875	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272007876	Walker A/P-loop; other site
331272007877	ATP binding site [chemical binding]; other site
331272007878	Q-loop/lid; other site
331272007879	ABC transporter signature motif; other site
331272007880	Walker B; other site
331272007881	D-loop; other site
331272007882	H-loop/switch region; other site
331272007883	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272007884	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272007885	Walker A/P-loop; other site
331272007886	ATP binding site [chemical binding]; other site
331272007887	Q-loop/lid; other site
331272007888	ABC transporter signature motif; other site
331272007889	Walker B; other site
331272007890	D-loop; other site
331272007891	H-loop/switch region; other site
331272007892	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272007893	TM-ABC transporter signature motif; other site
331272007894	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272007895	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272007896	TM-ABC transporter signature motif; other site
331272007897	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
331272007898	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
331272007899	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331272007900	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
331272007901	hypothetical protein; Reviewed; Region: PRK00024
331272007902	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
331272007903	MPN+ (JAMM) motif; other site
331272007904	Zinc-binding site [ion binding]; other site
331272007905	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
331272007906	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
331272007907	L-aspartate oxidase; Provisional; Region: PRK09077
331272007908	L-aspartate oxidase; Provisional; Region: PRK06175
331272007909	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
331272007910	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
331272007911	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
331272007912	dimerization interface [polypeptide binding]; other site
331272007913	active site
331272007914	quinolinate synthetase; Provisional; Region: PRK09375
331272007915	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
331272007916	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272007917	Di-iron ligands [ion binding]; other site
331272007918	Transposase; Region: DDE_Tnp_ISL3; pfam01610
331272007919	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272007920	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272007921	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
331272007922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272007923	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
331272007924	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
331272007925	active site
331272007926	substrate binding site [chemical binding]; other site
331272007927	cosubstrate binding site; other site
331272007928	catalytic site [active]
331272007929	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
331272007930	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
331272007931	active site
331272007932	Riboflavin kinase; Region: Flavokinase; smart00904
331272007933	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
331272007934	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272007935	active site
331272007936	HIGH motif; other site
331272007937	nucleotide binding site [chemical binding]; other site
331272007938	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
331272007939	active site
331272007940	KMSKS motif; other site
331272007941	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
331272007942	tRNA binding surface [nucleotide binding]; other site
331272007943	anticodon binding site; other site
331272007944	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
331272007945	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
331272007946	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
331272007947	Flavoprotein; Region: Flavoprotein; pfam02441
331272007948	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
331272007949	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
331272007950	trimer interface [polypeptide binding]; other site
331272007951	active site
331272007952	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
331272007953	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
331272007954	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
331272007955	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
331272007956	Clp amino terminal domain; Region: Clp_N; pfam02861
331272007957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272007958	Walker A motif; other site
331272007959	ATP binding site [chemical binding]; other site
331272007960	Walker B motif; other site
331272007961	arginine finger; other site
331272007962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272007963	Walker A motif; other site
331272007964	ATP binding site [chemical binding]; other site
331272007965	Walker B motif; other site
331272007966	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
331272007967	Uncharacterized conserved protein [Function unknown]; Region: COG2127
331272007968	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272007969	DNA-binding site [nucleotide binding]; DNA binding site
331272007970	RNA-binding motif; other site
331272007971	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
331272007972	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
331272007973	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
331272007974	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
331272007975	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
331272007976	isocitrate dehydrogenase; Validated; Region: PRK07362
331272007977	isocitrate dehydrogenase; Reviewed; Region: PRK07006
331272007978	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
331272007979	pseudouridine synthase; Region: TIGR00093
331272007980	active site
331272007981	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
331272007982	elongation factor G; Reviewed; Region: PRK00007
331272007983	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
331272007984	G1 box; other site
331272007985	putative GEF interaction site [polypeptide binding]; other site
331272007986	GTP/Mg2+ binding site [chemical binding]; other site
331272007987	Switch I region; other site
331272007988	G2 box; other site
331272007989	G3 box; other site
331272007990	Switch II region; other site
331272007991	G4 box; other site
331272007992	G5 box; other site
331272007993	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
331272007994	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
331272007995	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
331272007996	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
331272007997	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272007998	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272007999	active site
331272008000	catalytic tetrad [active]
331272008001	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
331272008002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272008003	DNA-binding site [nucleotide binding]; DNA binding site
331272008004	UTRA domain; Region: UTRA; pfam07702
331272008005	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272008006	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272008007	MerR family regulatory protein; Region: MerR; pfam00376
331272008008	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
331272008009	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
331272008010	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
331272008011	dimer interface [polypeptide binding]; other site
331272008012	active site
331272008013	oxalacetate/citrate binding site [chemical binding]; other site
331272008014	citrylCoA binding site [chemical binding]; other site
331272008015	coenzyme A binding site [chemical binding]; other site
331272008016	catalytic triad [active]
331272008017	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
331272008018	putative transporter; Provisional; Region: PRK10504
331272008019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008020	putative substrate translocation pore; other site
331272008021	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272008022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331272008023	S-adenosylmethionine binding site [chemical binding]; other site
331272008024	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
331272008025	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272008026	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272008027	Predicted membrane protein [Function unknown]; Region: COG4539
331272008028	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
331272008029	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272008030	ligand binding site [chemical binding]; other site
331272008031	flexible hinge region; other site
331272008032	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
331272008033	putative switch regulator; other site
331272008034	non-specific DNA interactions [nucleotide binding]; other site
331272008035	DNA binding site [nucleotide binding]
331272008036	sequence specific DNA binding site [nucleotide binding]; other site
331272008037	putative cAMP binding site [chemical binding]; other site
331272008038	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
331272008039	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
331272008040	Chromate transporter; Region: Chromate_transp; pfam02417
331272008041	superoxide dismutase; Provisional; Region: PRK10543
331272008042	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
331272008043	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
331272008044	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
331272008045	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
331272008046	generic binding surface II; other site
331272008047	generic binding surface I; other site
331272008048	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
331272008049	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
331272008050	Uncharacterized conserved protein [Function unknown]; Region: COG2835
331272008051	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
331272008052	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
331272008053	Ligand binding site; other site
331272008054	oligomer interface; other site
331272008055	adenylate kinase; Reviewed; Region: adk; PRK00279
331272008056	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
331272008057	AMP-binding site [chemical binding]; other site
331272008058	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
331272008059	Uncharacterized conserved protein [Function unknown]; Region: COG2912
331272008060	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
331272008061	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
331272008062	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
331272008063	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
331272008064	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
331272008065	ornithine carbamoyltransferase; Provisional; Region: PRK00779
331272008066	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
331272008067	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
331272008068	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
331272008069	FAD binding domain; Region: FAD_binding_4; pfam01565
331272008070	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
331272008071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
331272008072	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
331272008073	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
331272008074	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
331272008075	putative deacylase active site [active]
331272008076	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
331272008077	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272008078	acyl-activating enzyme (AAE) consensus motif; other site
331272008079	AMP binding site [chemical binding]; other site
331272008080	active site
331272008081	CoA binding site [chemical binding]; other site
331272008082	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
331272008083	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
331272008084	active site
331272008085	Int/Topo IB signature motif; other site
331272008086	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
331272008087	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
331272008088	DNA binding site [nucleotide binding]
331272008089	active site
331272008090	epoxyqueuosine reductase; Region: TIGR00276
331272008091	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
331272008092	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
331272008093	AMIN domain; Region: AMIN; pfam11741
331272008094	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
331272008095	active site
331272008096	metal binding site [ion binding]; metal-binding site
331272008097	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
331272008098	EamA-like transporter family; Region: EamA; pfam00892
331272008099	Pirin-related protein [General function prediction only]; Region: COG1741
331272008100	Pirin; Region: Pirin; pfam02678
331272008101	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
331272008102	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
331272008103	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331272008104	catalytic residues [active]
331272008105	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
331272008106	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
331272008107	putative ATP binding site [chemical binding]; other site
331272008108	putative substrate interface [chemical binding]; other site
331272008109	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
331272008110	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
331272008111	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
331272008112	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
331272008113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272008114	S-adenosylmethionine binding site [chemical binding]; other site
331272008115	Protein of unknown function DUF72; Region: DUF72; pfam01904
331272008116	methionine sulfoxide reductase A; Provisional; Region: PRK14054
331272008117	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
331272008118	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
331272008119	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272008120	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272008121	putative DNA binding site [nucleotide binding]; other site
331272008122	putative Zn2+ binding site [ion binding]; other site
331272008123	AsnC family; Region: AsnC_trans_reg; pfam01037
331272008124	arylformamidase; Region: trp_arylform; TIGR03035
331272008125	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
331272008126	kynureninase; Region: kynureninase; TIGR01814
331272008127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272008128	catalytic residue [active]
331272008129	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
331272008130	benzoate transport; Region: 2A0115; TIGR00895
331272008131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008132	putative substrate translocation pore; other site
331272008133	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
331272008134	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272008135	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272008136	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
331272008137	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
331272008138	NAD(P) binding site [chemical binding]; other site
331272008139	catalytic residues [active]
331272008140	benzoylformate decarboxylase; Reviewed; Region: PRK07092
331272008141	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272008142	PYR/PP interface [polypeptide binding]; other site
331272008143	dimer interface [polypeptide binding]; other site
331272008144	TPP binding site [chemical binding]; other site
331272008145	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272008146	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
331272008147	TPP-binding site [chemical binding]; other site
331272008148	dimer interface [polypeptide binding]; other site
331272008149	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272008150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272008151	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
331272008152	putative dimerization interface [polypeptide binding]; other site
331272008153	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
331272008154	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
331272008155	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
331272008156	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
331272008157	N- and C-terminal domain interface [polypeptide binding]; other site
331272008158	D-xylulose kinase; Region: XylB; TIGR01312
331272008159	active site
331272008160	MgATP binding site [chemical binding]; other site
331272008161	catalytic site [active]
331272008162	metal binding site [ion binding]; metal-binding site
331272008163	xylulose binding site [chemical binding]; other site
331272008164	homodimer interface [polypeptide binding]; other site
331272008165	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
331272008166	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
331272008167	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272008168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008169	putative substrate translocation pore; other site
331272008170	Beta-lactamase; Region: Beta-lactamase; pfam00144
331272008171	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331272008172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272008173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272008174	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
331272008175	putative effector binding pocket; other site
331272008176	putative dimerization interface [polypeptide binding]; other site
331272008177	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
331272008178	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272008179	Walker A/P-loop; other site
331272008180	ATP binding site [chemical binding]; other site
331272008181	Q-loop/lid; other site
331272008182	ABC transporter signature motif; other site
331272008183	Walker B; other site
331272008184	D-loop; other site
331272008185	H-loop/switch region; other site
331272008186	TOBE domain; Region: TOBE; pfam03459
331272008187	TOBE domain; Region: TOBE_2; pfam08402
331272008188	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
331272008189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272008190	motif II; other site
331272008191	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272008192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272008193	dimer interface [polypeptide binding]; other site
331272008194	conserved gate region; other site
331272008195	putative PBP binding loops; other site
331272008196	ABC-ATPase subunit interface; other site
331272008197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272008198	dimer interface [polypeptide binding]; other site
331272008199	conserved gate region; other site
331272008200	putative PBP binding loops; other site
331272008201	ABC-ATPase subunit interface; other site
331272008202	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272008203	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272008204	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
331272008205	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
331272008206	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272008207	substrate binding site [chemical binding]; other site
331272008208	ATP binding site [chemical binding]; other site
331272008209	sorbitol dehydrogenase; Provisional; Region: PRK07067
331272008210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272008211	NAD(P) binding site [chemical binding]; other site
331272008212	active site
331272008213	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
331272008214	metal binding site 2 [ion binding]; metal-binding site
331272008215	putative DNA binding helix; other site
331272008216	metal binding site 1 [ion binding]; metal-binding site
331272008217	dimer interface [polypeptide binding]; other site
331272008218	structural Zn2+ binding site [ion binding]; other site
331272008219	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
331272008220	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
331272008221	metal binding site [ion binding]; metal-binding site
331272008222	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
331272008223	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
331272008224	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
331272008225	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
331272008226	ABC-ATPase subunit  interface; other site
331272008227	dimer interface [polypeptide binding]; other site
331272008228	S-formylglutathione hydrolase; Region: PLN02442
331272008229	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
331272008230	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
331272008231	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
331272008232	substrate binding site [chemical binding]; other site
331272008233	catalytic Zn binding site [ion binding]; other site
331272008234	NAD binding site [chemical binding]; other site
331272008235	structural Zn binding site [ion binding]; other site
331272008236	dimer interface [polypeptide binding]; other site
331272008237	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
331272008238	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
331272008239	nucleotide binding site [chemical binding]; other site
331272008240	xanthine permease; Region: pbuX; TIGR03173
331272008241	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
331272008242	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331272008243	Protein export membrane protein; Region: SecD_SecF; cl14618
331272008244	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
331272008245	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
331272008246	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272008247	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272008248	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
331272008249	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272008250	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
331272008251	Isochorismatase family; Region: Isochorismatase; pfam00857
331272008252	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
331272008253	catalytic triad [active]
331272008254	conserved cis-peptide bond; other site
331272008255	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
331272008256	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272008257	conserved cys residue [active]
331272008258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272008259	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272008260	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
331272008261	hydrophobic ligand binding site; other site
331272008262	Domain of unknown function (DUF427); Region: DUF427; pfam04248
331272008263	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
331272008264	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
331272008265	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331272008266	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272008267	protein binding site [polypeptide binding]; other site
331272008268	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272008269	protein binding site [polypeptide binding]; other site
331272008270	sensor protein QseC; Provisional; Region: PRK10337
331272008271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272008272	dimer interface [polypeptide binding]; other site
331272008273	phosphorylation site [posttranslational modification]
331272008274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272008275	ATP binding site [chemical binding]; other site
331272008276	Mg2+ binding site [ion binding]; other site
331272008277	G-X-G motif; other site
331272008278	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
331272008279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272008280	active site
331272008281	phosphorylation site [posttranslational modification]
331272008282	intermolecular recognition site; other site
331272008283	dimerization interface [polypeptide binding]; other site
331272008284	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272008285	DNA binding site [nucleotide binding]
331272008286	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
331272008287	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
331272008288	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
331272008289	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
331272008290	active site
331272008291	catalytic triad [active]
331272008292	oxyanion hole [active]
331272008293	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
331272008294	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
331272008295	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
331272008296	ATP-grasp domain; Region: ATP-grasp; pfam02222
331272008297	AIR carboxylase; Region: AIRC; pfam00731
331272008298	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
331272008299	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
331272008300	ATP binding site [chemical binding]; other site
331272008301	active site
331272008302	substrate binding site [chemical binding]; other site
331272008303	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
331272008304	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
331272008305	intersubunit interface [polypeptide binding]; other site
331272008306	active site
331272008307	zinc binding site [ion binding]; other site
331272008308	Na+ binding site [ion binding]; other site
331272008309	pyruvate kinase; Provisional; Region: PRK05826
331272008310	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
331272008311	domain interfaces; other site
331272008312	active site
331272008313	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
331272008314	Phosphoglycerate kinase; Region: PGK; pfam00162
331272008315	substrate binding site [chemical binding]; other site
331272008316	hinge regions; other site
331272008317	ADP binding site [chemical binding]; other site
331272008318	catalytic site [active]
331272008319	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
331272008320	AzlC protein; Region: AzlC; cl00570
331272008321	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331272008322	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
331272008323	homodimer interface [polypeptide binding]; other site
331272008324	substrate-cofactor binding pocket; other site
331272008325	catalytic residue [active]
331272008326	Zinc-finger domain; Region: zf-CHCC; cl01821
331272008327	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272008328	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272008329	putative active site [active]
331272008330	SnoaL-like domain; Region: SnoaL_3; pfam13474
331272008331	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
331272008332	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
331272008333	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
331272008334	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
331272008335	Peptidase family M48; Region: Peptidase_M48; pfam01435
331272008336	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
331272008337	trimer interface [polypeptide binding]; other site
331272008338	dimer interface [polypeptide binding]; other site
331272008339	putative active site [active]
331272008340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272008341	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272008342	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272008343	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272008344	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272008345	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
331272008346	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
331272008347	O-Antigen ligase; Region: Wzy_C; pfam04932
331272008348	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
331272008349	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
331272008350	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
331272008351	Pilin (bacterial filament); Region: Pilin; pfam00114
331272008352	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
331272008353	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
331272008354	CoA binding domain; Region: CoA_binding; smart00881
331272008355	CoA-ligase; Region: Ligase_CoA; pfam00549
331272008356	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
331272008357	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
331272008358	CoA-ligase; Region: Ligase_CoA; pfam00549
331272008359	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
331272008360	recombination regulator RecX; Provisional; Region: recX; PRK14136
331272008361	recombinase A; Provisional; Region: recA; PRK09354
331272008362	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
331272008363	hexamer interface [polypeptide binding]; other site
331272008364	Walker A motif; other site
331272008365	ATP binding site [chemical binding]; other site
331272008366	Walker B motif; other site
331272008367	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272008368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272008369	active site
331272008370	phosphorylation site [posttranslational modification]
331272008371	intermolecular recognition site; other site
331272008372	dimerization interface [polypeptide binding]; other site
331272008373	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272008374	DNA binding site [nucleotide binding]
331272008375	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
331272008376	HAMP domain; Region: HAMP; pfam00672
331272008377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272008378	dimer interface [polypeptide binding]; other site
331272008379	phosphorylation site [posttranslational modification]
331272008380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272008381	ATP binding site [chemical binding]; other site
331272008382	Mg2+ binding site [ion binding]; other site
331272008383	G-X-G motif; other site
331272008384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008385	putative substrate translocation pore; other site
331272008386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272008387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272008388	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272008389	putative effector binding pocket; other site
331272008390	putative dimerization interface [polypeptide binding]; other site
331272008391	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272008392	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272008393	conserved cys residue [active]
331272008394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272008395	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272008396	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272008397	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
331272008398	conserved cys residue [active]
331272008399	Cupin domain; Region: Cupin_2; cl17218
331272008400	PAAR motif; Region: PAAR_motif; pfam05488
331272008401	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272008402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272008403	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272008404	putative effector binding pocket; other site
331272008405	dimerization interface [polypeptide binding]; other site
331272008406	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
331272008407	Transglycosylase; Region: Transgly; cl17702
331272008408	Uncharacterized conserved protein [Function unknown]; Region: COG3791
331272008409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
331272008410	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
331272008411	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272008412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272008413	DNA-binding site [nucleotide binding]; DNA binding site
331272008414	FCD domain; Region: FCD; pfam07729
331272008415	galactonate dehydratase; Provisional; Region: PRK14017
331272008416	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
331272008417	putative active site pocket [active]
331272008418	putative metal binding site [ion binding]; other site
331272008419	Copper resistance protein D; Region: CopD; pfam05425
331272008420	Cytochrome c; Region: Cytochrom_C; cl11414
331272008421	Cytochrome c; Region: Cytochrom_C; cl11414
331272008422	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272008423	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272008424	Cytochrome c; Region: Cytochrom_C; pfam00034
331272008425	helicase 45; Provisional; Region: PTZ00424
331272008426	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
331272008427	ATP binding site [chemical binding]; other site
331272008428	Mg++ binding site [ion binding]; other site
331272008429	motif III; other site
331272008430	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272008431	nucleotide binding region [chemical binding]; other site
331272008432	ATP-binding site [chemical binding]; other site
331272008433	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
331272008434	dinuclear metal binding motif [ion binding]; other site
331272008435	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
331272008436	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
331272008437	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
331272008438	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
331272008439	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
331272008440	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
331272008441	glycerol kinase; Provisional; Region: glpK; PRK00047
331272008442	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
331272008443	N- and C-terminal domain interface [polypeptide binding]; other site
331272008444	active site
331272008445	MgATP binding site [chemical binding]; other site
331272008446	catalytic site [active]
331272008447	metal binding site [ion binding]; metal-binding site
331272008448	glycerol binding site [chemical binding]; other site
331272008449	homotetramer interface [polypeptide binding]; other site
331272008450	homodimer interface [polypeptide binding]; other site
331272008451	FBP binding site [chemical binding]; other site
331272008452	protein IIAGlc interface [polypeptide binding]; other site
331272008453	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
331272008454	amphipathic channel; other site
331272008455	Asn-Pro-Ala signature motifs; other site
331272008456	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
331272008457	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272008458	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
331272008459	[2Fe-2S] cluster binding site [ion binding]; other site
331272008460	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
331272008461	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
331272008462	putative di-iron ligands [ion binding]; other site
331272008463	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272008464	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
331272008465	putative ligand binding site [chemical binding]; other site
331272008466	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272008467	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
331272008468	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
331272008469	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272008470	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
331272008471	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
331272008472	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272008473	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
331272008474	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
331272008475	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272008476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272008477	non-specific DNA binding site [nucleotide binding]; other site
331272008478	salt bridge; other site
331272008479	sequence-specific DNA binding site [nucleotide binding]; other site
331272008480	Cupin domain; Region: Cupin_2; pfam07883
331272008481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008482	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272008483	putative substrate translocation pore; other site
331272008484	transcriptional regulator; Provisional; Region: PRK10632
331272008485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272008486	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272008487	putative effector binding pocket; other site
331272008488	dimerization interface [polypeptide binding]; other site
331272008489	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
331272008490	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
331272008491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272008492	FeS/SAM binding site; other site
331272008493	TRAM domain; Region: TRAM; pfam01938
331272008494	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
331272008495	PhoH-like protein; Region: PhoH; pfam02562
331272008496	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
331272008497	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
331272008498	putative active site pocket [active]
331272008499	dimerization interface [polypeptide binding]; other site
331272008500	putative catalytic residue [active]
331272008501	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
331272008502	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331272008503	Transporter associated domain; Region: CorC_HlyC; smart01091
331272008504	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
331272008505	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
331272008506	putative active site [active]
331272008507	catalytic triad [active]
331272008508	putative dimer interface [polypeptide binding]; other site
331272008509	TPR repeat; Region: TPR_11; pfam13414
331272008510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272008511	binding surface
331272008512	TPR motif; other site
331272008513	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272008514	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
331272008515	dimer interface [polypeptide binding]; other site
331272008516	motif 1; other site
331272008517	active site
331272008518	motif 2; other site
331272008519	motif 3; other site
331272008520	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
331272008521	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
331272008522	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
331272008523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272008524	active site
331272008525	motif I; other site
331272008526	motif II; other site
331272008527	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
331272008528	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
331272008529	putative acyl-acceptor binding pocket; other site
331272008530	Protein of unknown function DUF45; Region: DUF45; pfam01863
331272008531	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272008532	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
331272008533	dimer interface [polypeptide binding]; other site
331272008534	active site
331272008535	metal binding site [ion binding]; metal-binding site
331272008536	glutathione binding site [chemical binding]; other site
331272008537	EamA-like transporter family; Region: EamA; pfam00892
331272008538	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
331272008539	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
331272008540	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
331272008541	SurA N-terminal domain; Region: SurA_N; pfam09312
331272008542	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
331272008543	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
331272008544	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
331272008545	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
331272008546	Organic solvent tolerance protein; Region: OstA_C; pfam04453
331272008547	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
331272008548	Phosphotransferase enzyme family; Region: APH; pfam01636
331272008549	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
331272008550	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
331272008551	Substrate binding site; other site
331272008552	metal-binding site
331272008553	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272008554	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
331272008555	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
331272008556	Walker A/P-loop; other site
331272008557	ATP binding site [chemical binding]; other site
331272008558	Q-loop/lid; other site
331272008559	ABC transporter signature motif; other site
331272008560	Walker B; other site
331272008561	D-loop; other site
331272008562	H-loop/switch region; other site
331272008563	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
331272008564	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
331272008565	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
331272008566	enoyl-CoA hydratase; Provisional; Region: PRK06688
331272008567	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272008568	substrate binding site [chemical binding]; other site
331272008569	oxyanion hole (OAH) forming residues; other site
331272008570	trimer interface [polypeptide binding]; other site
331272008571	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
331272008572	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
331272008573	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272008574	dimer interface [polypeptide binding]; other site
331272008575	active site
331272008576	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
331272008577	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272008578	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272008579	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
331272008580	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272008581	substrate binding site [chemical binding]; other site
331272008582	oxyanion hole (OAH) forming residues; other site
331272008583	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
331272008584	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
331272008585	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
331272008586	FAD binding site [chemical binding]; other site
331272008587	substrate binding site [chemical binding]; other site
331272008588	catalytic residues [active]
331272008589	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
331272008590	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272008591	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272008592	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
331272008593	PLD-like domain; Region: PLDc_2; pfam13091
331272008594	putative active site [active]
331272008595	catalytic site [active]
331272008596	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
331272008597	PLD-like domain; Region: PLDc_2; pfam13091
331272008598	putative active site [active]
331272008599	catalytic site [active]
331272008600	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
331272008601	nudix motif; other site
331272008602	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
331272008603	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
331272008604	dimer interface [polypeptide binding]; other site
331272008605	anticodon binding site; other site
331272008606	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
331272008607	homodimer interface [polypeptide binding]; other site
331272008608	motif 1; other site
331272008609	active site
331272008610	motif 2; other site
331272008611	GAD domain; Region: GAD; pfam02938
331272008612	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
331272008613	motif 3; other site
331272008614	Uncharacterized conserved protein [Function unknown]; Region: COG2928
331272008615	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
331272008616	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
331272008617	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
331272008618	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
331272008619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
331272008620	SCP-2 sterol transfer family; Region: SCP2; pfam02036
331272008621	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
331272008622	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
331272008623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272008624	S-adenosylmethionine binding site [chemical binding]; other site
331272008625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
331272008626	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
331272008627	nucleotide binding site/active site [active]
331272008628	HIT family signature motif; other site
331272008629	catalytic residue [active]
331272008630	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
331272008631	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272008632	FAD binding domain; Region: FAD_binding_4; pfam01565
331272008633	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272008634	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
331272008635	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
331272008636	Cysteine-rich domain; Region: CCG; pfam02754
331272008637	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
331272008638	threonine dehydratase; Reviewed; Region: PRK09224
331272008639	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
331272008640	tetramer interface [polypeptide binding]; other site
331272008641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272008642	catalytic residue [active]
331272008643	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
331272008644	putative Ile/Val binding site [chemical binding]; other site
331272008645	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
331272008646	putative Ile/Val binding site [chemical binding]; other site
331272008647	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
331272008648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
331272008649	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
331272008650	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
331272008651	dimer interface [polypeptide binding]; other site
331272008652	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272008653	ligand binding site [chemical binding]; other site
331272008654	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
331272008655	homotrimer interaction site [polypeptide binding]; other site
331272008656	putative active site [active]
331272008657	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
331272008658	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
331272008659	active site
331272008660	putative substrate binding pocket [chemical binding]; other site
331272008661	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272008662	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272008663	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272008664	putative active site [active]
331272008665	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
331272008666	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
331272008667	dimer interface [polypeptide binding]; other site
331272008668	active site
331272008669	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272008670	substrate binding site [chemical binding]; other site
331272008671	catalytic residue [active]
331272008672	intracellular protease, PfpI family; Region: PfpI; TIGR01382
331272008673	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
331272008674	conserved cys residue [active]
331272008675	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272008676	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
331272008677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008678	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272008679	putative substrate translocation pore; other site
331272008680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008681	EcsC protein family; Region: EcsC; pfam12787
331272008682	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272008683	CHRD domain; Region: CHRD; pfam07452
331272008684	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
331272008685	aldolase II superfamily protein; Provisional; Region: PRK07044
331272008686	intersubunit interface [polypeptide binding]; other site
331272008687	active site
331272008688	Zn2+ binding site [ion binding]; other site
331272008689	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
331272008690	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
331272008691	putative active site [active]
331272008692	catalytic site [active]
331272008693	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
331272008694	putative active site [active]
331272008695	catalytic site [active]
331272008696	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
331272008697	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
331272008698	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
331272008699	Ligand binding site; other site
331272008700	Putative Catalytic site; other site
331272008701	DXD motif; other site
331272008702	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
331272008703	homotrimer interaction site [polypeptide binding]; other site
331272008704	putative active site [active]
331272008705	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272008706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272008707	NAD(P) binding site [chemical binding]; other site
331272008708	active site
331272008709	acyl carrier protein; Provisional; Region: PRK09184
331272008710	Predicted membrane protein [Function unknown]; Region: COG4648
331272008711	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
331272008712	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272008713	acyl-activating enzyme (AAE) consensus motif; other site
331272008714	AMP binding site [chemical binding]; other site
331272008715	active site
331272008716	CoA binding site [chemical binding]; other site
331272008717	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
331272008718	putative acyl-acceptor binding pocket; other site
331272008719	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
331272008720	Predicted exporter [General function prediction only]; Region: COG4258
331272008721	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
331272008722	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
331272008723	NodB motif; other site
331272008724	active site
331272008725	catalytic site [active]
331272008726	metal binding site [ion binding]; metal-binding site
331272008727	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
331272008728	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
331272008729	dimer interface [polypeptide binding]; other site
331272008730	active site
331272008731	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
331272008732	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
331272008733	putative active site 1 [active]
331272008734	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
331272008735	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
331272008736	NAD(P) binding site [chemical binding]; other site
331272008737	homotetramer interface [polypeptide binding]; other site
331272008738	homodimer interface [polypeptide binding]; other site
331272008739	active site
331272008740	putative acyltransferase; Provisional; Region: PRK05790
331272008741	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272008742	dimer interface [polypeptide binding]; other site
331272008743	active site
331272008744	Phasin protein; Region: Phasin_2; pfam09361
331272008745	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331272008746	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272008747	P-loop; other site
331272008748	Magnesium ion binding site [ion binding]; other site
331272008749	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272008750	Magnesium ion binding site [ion binding]; other site
331272008751	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
331272008752	active site
331272008753	DNA binding site [nucleotide binding]
331272008754	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
331272008755	active site
331272008756	SUMO-1 interface [polypeptide binding]; other site
331272008757	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
331272008758	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
331272008759	dimer interface [polypeptide binding]; other site
331272008760	ssDNA binding site [nucleotide binding]; other site
331272008761	tetramer (dimer of dimers) interface [polypeptide binding]; other site
331272008762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272008763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272008764	putative substrate translocation pore; other site
331272008765	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
331272008766	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331272008767	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331272008768	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
331272008769	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
331272008770	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
331272008771	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
331272008772	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
331272008773	putative active site [active]
331272008774	putative substrate binding site [chemical binding]; other site
331272008775	putative cosubstrate binding site; other site
331272008776	catalytic site [active]
331272008777	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331272008778	nudix motif; other site
331272008779	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272008780	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272008781	active site
331272008782	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
331272008783	TrkA-N domain; Region: TrkA_N; pfam02254
331272008784	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
331272008785	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
331272008786	putative active site [active]
331272008787	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
331272008788	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
331272008789	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
331272008790	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
331272008791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
331272008792	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
331272008793	OstA-like protein; Region: OstA; pfam03968
331272008794	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
331272008795	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
331272008796	Walker A/P-loop; other site
331272008797	ATP binding site [chemical binding]; other site
331272008798	Q-loop/lid; other site
331272008799	ABC transporter signature motif; other site
331272008800	Walker B; other site
331272008801	D-loop; other site
331272008802	H-loop/switch region; other site
331272008803	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
331272008804	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
331272008805	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
331272008806	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
331272008807	30S subunit binding site; other site
331272008808	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
331272008809	active site
331272008810	phosphorylation site [posttranslational modification]
331272008811	HPr kinase/phosphorylase; Provisional; Region: PRK05428
331272008812	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
331272008813	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
331272008814	Hpr binding site; other site
331272008815	active site
331272008816	homohexamer subunit interaction site [polypeptide binding]; other site
331272008817	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
331272008818	AAA domain; Region: AAA_18; pfam13238
331272008819	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
331272008820	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
331272008821	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331272008822	minor groove reading motif; other site
331272008823	helix-hairpin-helix signature motif; other site
331272008824	substrate binding pocket [chemical binding]; other site
331272008825	active site
331272008826	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
331272008827	DNA binding and oxoG recognition site [nucleotide binding]
331272008828	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
331272008829	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
331272008830	DNA binding site [nucleotide binding]
331272008831	catalytic residue [active]
331272008832	H2TH interface [polypeptide binding]; other site
331272008833	putative catalytic residues [active]
331272008834	turnover-facilitating residue; other site
331272008835	intercalation triad [nucleotide binding]; other site
331272008836	8OG recognition residue [nucleotide binding]; other site
331272008837	putative reading head residues; other site
331272008838	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
331272008839	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
331272008840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272008841	binding surface
331272008842	TPR motif; other site
331272008843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272008844	TPR motif; other site
331272008845	binding surface
331272008846	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
331272008847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272008848	binding surface
331272008849	TPR motif; other site
331272008850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272008851	binding surface
331272008852	TPR motif; other site
331272008853	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
331272008854	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
331272008855	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
331272008856	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
331272008857	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
331272008858	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
331272008859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272008860	active site
331272008861	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
331272008862	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
331272008863	5S rRNA interface [nucleotide binding]; other site
331272008864	CTC domain interface [polypeptide binding]; other site
331272008865	L16 interface [polypeptide binding]; other site
331272008866	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
331272008867	putative active site [active]
331272008868	catalytic residue [active]
331272008869	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
331272008870	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272008871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272008872	homodimer interface [polypeptide binding]; other site
331272008873	catalytic residue [active]
331272008874	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
331272008875	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
331272008876	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
331272008877	active site
331272008878	(T/H)XGH motif; other site
331272008879	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
331272008880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272008881	S-adenosylmethionine binding site [chemical binding]; other site
331272008882	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
331272008883	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
331272008884	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
331272008885	P loop; other site
331272008886	GTP binding site [chemical binding]; other site
331272008887	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
331272008888	maleylacetoacetate isomerase; Region: maiA; TIGR01262
331272008889	C-terminal domain interface [polypeptide binding]; other site
331272008890	GSH binding site (G-site) [chemical binding]; other site
331272008891	putative dimer interface [polypeptide binding]; other site
331272008892	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
331272008893	dimer interface [polypeptide binding]; other site
331272008894	N-terminal domain interface [polypeptide binding]; other site
331272008895	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
331272008896	glycosyl transferase family protein; Provisional; Region: PRK08136
331272008897	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
331272008898	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
331272008899	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
331272008900	active site
331272008901	catalytic residues [active]
331272008902	metal binding site [ion binding]; metal-binding site
331272008903	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
331272008904	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
331272008905	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
331272008906	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331272008907	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272008908	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272008909	DNA binding residues [nucleotide binding]
331272008910	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
331272008911	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
331272008912	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
331272008913	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
331272008914	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
331272008915	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
331272008916	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
331272008917	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
331272008918	active site
331272008919	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
331272008920	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
331272008921	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
331272008922	active site turn [active]
331272008923	phosphorylation site [posttranslational modification]
331272008924	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
331272008925	HPr interaction site; other site
331272008926	glycerol kinase (GK) interaction site [polypeptide binding]; other site
331272008927	active site
331272008928	phosphorylation site [posttranslational modification]
331272008929	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
331272008930	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
331272008931	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
331272008932	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
331272008933	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
331272008934	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331272008935	dimer interface [polypeptide binding]; other site
331272008936	active site
331272008937	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331272008938	dimer interface [polypeptide binding]; other site
331272008939	active site
331272008940	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
331272008941	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
331272008942	active site
331272008943	dimer interface [polypeptide binding]; other site
331272008944	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
331272008945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272008946	DNA-binding site [nucleotide binding]; DNA binding site
331272008947	UTRA domain; Region: UTRA; pfam07702
331272008948	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
331272008949	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
331272008950	putative active site [active]
331272008951	putative PHP Thumb interface [polypeptide binding]; other site
331272008952	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
331272008953	generic binding surface II; other site
331272008954	generic binding surface I; other site
331272008955	DNA Polymerase Y-family; Region: PolY_like; cd03468
331272008956	active site
331272008957	DNA binding site [nucleotide binding]
331272008958	Cell division inhibitor SulA; Region: SulA; cl01880
331272008959	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
331272008960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272008961	Walker A/P-loop; other site
331272008962	ATP binding site [chemical binding]; other site
331272008963	Q-loop/lid; other site
331272008964	ABC transporter signature motif; other site
331272008965	Walker B; other site
331272008966	D-loop; other site
331272008967	H-loop/switch region; other site
331272008968	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272008969	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
331272008970	TM-ABC transporter signature motif; other site
331272008971	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
331272008972	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272008973	zinc binding site [ion binding]; other site
331272008974	putative ligand binding site [chemical binding]; other site
331272008975	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
331272008976	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
331272008977	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
331272008978	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272008979	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272008980	dimer interface [polypeptide binding]; other site
331272008981	putative CheW interface [polypeptide binding]; other site
331272008982	YCII-related domain; Region: YCII; cl00999
331272008983	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
331272008984	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
331272008985	Cu(I) binding site [ion binding]; other site
331272008986	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
331272008987	UbiA prenyltransferase family; Region: UbiA; pfam01040
331272008988	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
331272008989	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
331272008990	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331272008991	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
331272008992	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
331272008993	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
331272008994	Subunit III/VIIa interface [polypeptide binding]; other site
331272008995	Phospholipid binding site [chemical binding]; other site
331272008996	Subunit I/III interface [polypeptide binding]; other site
331272008997	Subunit III/VIb interface [polypeptide binding]; other site
331272008998	Subunit III/VIa interface; other site
331272008999	Subunit III/Vb interface [polypeptide binding]; other site
331272009000	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
331272009001	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
331272009002	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
331272009003	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
331272009004	Subunit I/III interface [polypeptide binding]; other site
331272009005	D-pathway; other site
331272009006	Subunit I/VIIc interface [polypeptide binding]; other site
331272009007	Subunit I/IV interface [polypeptide binding]; other site
331272009008	Subunit I/II interface [polypeptide binding]; other site
331272009009	Low-spin heme (heme a) binding site [chemical binding]; other site
331272009010	Subunit I/VIIa interface [polypeptide binding]; other site
331272009011	Subunit I/VIa interface [polypeptide binding]; other site
331272009012	Dimer interface; other site
331272009013	Putative water exit pathway; other site
331272009014	Binuclear center (heme a3/CuB) [ion binding]; other site
331272009015	K-pathway; other site
331272009016	Subunit I/Vb interface [polypeptide binding]; other site
331272009017	Putative proton exit pathway; other site
331272009018	Subunit I/VIb interface; other site
331272009019	Subunit I/VIc interface [polypeptide binding]; other site
331272009020	Electron transfer pathway; other site
331272009021	Subunit I/VIIIb interface [polypeptide binding]; other site
331272009022	Subunit I/VIIb interface [polypeptide binding]; other site
331272009023	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
331272009024	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
331272009025	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
331272009026	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272009027	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
331272009028	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272009029	ligand binding site [chemical binding]; other site
331272009030	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
331272009031	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
331272009032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272009033	S-adenosylmethionine binding site [chemical binding]; other site
331272009034	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
331272009035	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
331272009036	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
331272009037	putative ADP-ribose binding site [chemical binding]; other site
331272009038	putative active site [active]
331272009039	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
331272009040	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331272009041	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
331272009042	preprotein translocase subunit SecB; Validated; Region: PRK05751
331272009043	SecA binding site; other site
331272009044	Preprotein binding site; other site
331272009045	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
331272009046	GSH binding site [chemical binding]; other site
331272009047	catalytic residues [active]
331272009048	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331272009049	active site residue [active]
331272009050	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272009051	catalytic core [active]
331272009052	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272009053	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
331272009054	C-terminal peptidase (prc); Region: prc; TIGR00225
331272009055	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
331272009056	protein binding site [polypeptide binding]; other site
331272009057	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
331272009058	Catalytic dyad [active]
331272009059	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
331272009060	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
331272009061	ATP binding site [chemical binding]; other site
331272009062	substrate interface [chemical binding]; other site
331272009063	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
331272009064	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
331272009065	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
331272009066	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
331272009067	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
331272009068	dimerization domain swap beta strand [polypeptide binding]; other site
331272009069	regulatory protein interface [polypeptide binding]; other site
331272009070	active site
331272009071	regulatory phosphorylation site [posttranslational modification]; other site
331272009072	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
331272009073	active pocket/dimerization site; other site
331272009074	active site
331272009075	phosphorylation site [posttranslational modification]
331272009076	glutathione synthetase; Provisional; Region: PRK05246
331272009077	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
331272009078	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
331272009079	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
331272009080	Glutamate-cysteine ligase; Region: GshA; pfam08886
331272009081	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
331272009082	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
331272009083	Nitrogen regulatory protein P-II; Region: P-II; smart00938
331272009084	Membrane fusogenic activity; Region: BMFP; pfam04380
331272009085	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
331272009086	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
331272009087	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
331272009088	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
331272009089	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
331272009090	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272009091	catalytic residues [active]
331272009092	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272009093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272009094	active site
331272009095	phosphorylation site [posttranslational modification]
331272009096	intermolecular recognition site; other site
331272009097	dimerization interface [polypeptide binding]; other site
331272009098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272009099	Walker A motif; other site
331272009100	ATP binding site [chemical binding]; other site
331272009101	Walker B motif; other site
331272009102	arginine finger; other site
331272009103	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272009104	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
331272009105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272009106	dimer interface [polypeptide binding]; other site
331272009107	phosphorylation site [posttranslational modification]
331272009108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272009109	ATP binding site [chemical binding]; other site
331272009110	G-X-G motif; other site
331272009111	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
331272009112	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272009113	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
331272009114	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
331272009115	Na binding site [ion binding]; other site
331272009116	Protein of unknown function, DUF485; Region: DUF485; pfam04341
331272009117	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272009118	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272009119	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
331272009120	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
331272009121	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
331272009122	active site
331272009123	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
331272009124	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272009125	active site
331272009126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272009127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009128	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272009129	putative effector binding pocket; other site
331272009130	dimerization interface [polypeptide binding]; other site
331272009131	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
331272009132	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
331272009133	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272009134	trimer interface [polypeptide binding]; other site
331272009135	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
331272009136	Haemagglutinin; Region: HIM; pfam05662
331272009137	YadA-like C-terminal region; Region: YadA; pfam03895
331272009138	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272009139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009140	dimer interface [polypeptide binding]; other site
331272009141	conserved gate region; other site
331272009142	putative PBP binding loops; other site
331272009143	ABC-ATPase subunit interface; other site
331272009144	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
331272009145	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272009146	Walker A/P-loop; other site
331272009147	ATP binding site [chemical binding]; other site
331272009148	Q-loop/lid; other site
331272009149	ABC transporter signature motif; other site
331272009150	Walker B; other site
331272009151	D-loop; other site
331272009152	H-loop/switch region; other site
331272009153	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
331272009154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272009155	substrate binding pocket [chemical binding]; other site
331272009156	membrane-bound complex binding site; other site
331272009157	hinge residues; other site
331272009158	lipoyl synthase; Provisional; Region: PRK05481
331272009159	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272009160	FeS/SAM binding site; other site
331272009161	lipoate-protein ligase B; Provisional; Region: PRK14343
331272009162	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
331272009163	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272009164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009165	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272009166	dimerization interface [polypeptide binding]; other site
331272009167	substrate binding pocket [chemical binding]; other site
331272009168	hypothetical protein; Provisional; Region: PRK02047
331272009169	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
331272009170	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331272009171	homodimer interface [polypeptide binding]; other site
331272009172	substrate-cofactor binding pocket; other site
331272009173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272009174	catalytic residue [active]
331272009175	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
331272009176	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
331272009177	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
331272009178	Transposase domain (DUF772); Region: DUF772; pfam05598
331272009179	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331272009180	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
331272009181	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
331272009182	dimer interface [polypeptide binding]; other site
331272009183	[2Fe-2S] cluster binding site [ion binding]; other site
331272009184	Predicted integral membrane protein [Function unknown]; Region: COG5652
331272009185	Protein of unknown function (DUF330); Region: DUF330; pfam03886
331272009186	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
331272009187	mce related protein; Region: MCE; pfam02470
331272009188	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
331272009189	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
331272009190	Walker A/P-loop; other site
331272009191	ATP binding site [chemical binding]; other site
331272009192	Q-loop/lid; other site
331272009193	ABC transporter signature motif; other site
331272009194	Walker B; other site
331272009195	D-loop; other site
331272009196	H-loop/switch region; other site
331272009197	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
331272009198	Permease; Region: Permease; pfam02405
331272009199	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
331272009200	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
331272009201	active site
331272009202	metal binding site [ion binding]; metal-binding site
331272009203	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
331272009204	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272009205	Sel1-like repeats; Region: SEL1; smart00671
331272009206	biotin--protein ligase; Provisional; Region: PRK06955
331272009207	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
331272009208	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
331272009209	pantothenate kinase; Reviewed; Region: PRK13328
331272009210	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
331272009211	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
331272009212	active site
331272009213	HIGH motif; other site
331272009214	nucleotide binding site [chemical binding]; other site
331272009215	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
331272009216	dinuclear metal binding motif [ion binding]; other site
331272009217	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
331272009218	active site
331272009219	nucleophile elbow; other site
331272009220	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
331272009221	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272009222	substrate binding site [chemical binding]; other site
331272009223	oxyanion hole (OAH) forming residues; other site
331272009224	trimer interface [polypeptide binding]; other site
331272009225	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272009226	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272009227	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272009228	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272009229	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
331272009230	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
331272009231	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
331272009232	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
331272009233	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
331272009234	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
331272009235	substrate binding pocket [chemical binding]; other site
331272009236	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
331272009237	B12 binding site [chemical binding]; other site
331272009238	cobalt ligand [ion binding]; other site
331272009239	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
331272009240	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
331272009241	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
331272009242	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
331272009243	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
331272009244	active site
331272009245	HIGH motif; other site
331272009246	KMSK motif region; other site
331272009247	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
331272009248	tRNA binding surface [nucleotide binding]; other site
331272009249	anticodon binding site; other site
331272009250	Sporulation related domain; Region: SPOR; pfam05036
331272009251	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
331272009252	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
331272009253	catalytic residues [active]
331272009254	hinge region; other site
331272009255	alpha helical domain; other site
331272009256	short chain dehydrogenase; Provisional; Region: PRK07024
331272009257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272009258	NAD(P) binding site [chemical binding]; other site
331272009259	active site
331272009260	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
331272009261	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
331272009262	peptide binding site [polypeptide binding]; other site
331272009263	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
331272009264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272009265	Walker A/P-loop; other site
331272009266	ATP binding site [chemical binding]; other site
331272009267	Q-loop/lid; other site
331272009268	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272009269	ABC transporter signature motif; other site
331272009270	Walker B; other site
331272009271	D-loop; other site
331272009272	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
331272009273	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
331272009274	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
331272009275	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
331272009276	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
331272009277	active site clefts [active]
331272009278	zinc binding site [ion binding]; other site
331272009279	dimer interface [polypeptide binding]; other site
331272009280	C factor cell-cell signaling protein; Provisional; Region: PRK09009
331272009281	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
331272009282	NADP binding site [chemical binding]; other site
331272009283	homodimer interface [polypeptide binding]; other site
331272009284	active site
331272009285	hypothetical protein; Provisional; Region: PRK01842
331272009286	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
331272009287	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272009288	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
331272009289	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272009290	inhibitor-cofactor binding pocket; inhibition site
331272009291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272009292	catalytic residue [active]
331272009293	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
331272009294	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
331272009295	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272009296	catalytic residue [active]
331272009297	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
331272009298	AAA domain; Region: AAA_26; pfam13500
331272009299	biotin synthase; Provisional; Region: PRK15108
331272009300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272009301	FeS/SAM binding site; other site
331272009302	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
331272009303	CutC family; Region: CutC; cl01218
331272009304	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272009305	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
331272009306	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
331272009307	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
331272009308	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
331272009309	dimer interface [polypeptide binding]; other site
331272009310	PYR/PP interface [polypeptide binding]; other site
331272009311	TPP binding site [chemical binding]; other site
331272009312	substrate binding site [chemical binding]; other site
331272009313	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
331272009314	TPP-binding site; other site
331272009315	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
331272009316	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
331272009317	active site
331272009318	substrate binding site [chemical binding]; other site
331272009319	trimer interface [polypeptide binding]; other site
331272009320	CoA binding site [chemical binding]; other site
331272009321	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272009322	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
331272009323	putative C-terminal domain interface [polypeptide binding]; other site
331272009324	putative GSH binding site (G-site) [chemical binding]; other site
331272009325	putative dimer interface [polypeptide binding]; other site
331272009326	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
331272009327	dimer interface [polypeptide binding]; other site
331272009328	N-terminal domain interface [polypeptide binding]; other site
331272009329	putative substrate binding pocket (H-site) [chemical binding]; other site
331272009330	Inward rectifier potassium channel; Region: IRK; pfam01007
331272009331	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
331272009332	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
331272009333	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272009334	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
331272009335	dimer interface [polypeptide binding]; other site
331272009336	active site
331272009337	catalytic residue [active]
331272009338	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
331272009339	putative active site [active]
331272009340	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
331272009341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272009343	dimerization interface [polypeptide binding]; other site
331272009344	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272009345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272009346	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
331272009347	C-terminal domain interface [polypeptide binding]; other site
331272009348	GSH binding site (G-site) [chemical binding]; other site
331272009349	dimer interface [polypeptide binding]; other site
331272009350	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
331272009351	dimer interface [polypeptide binding]; other site
331272009352	substrate binding pocket (H-site) [chemical binding]; other site
331272009353	N-terminal domain interface [polypeptide binding]; other site
331272009354	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272009355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009356	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272009357	dimerization interface [polypeptide binding]; other site
331272009358	substrate binding pocket [chemical binding]; other site
331272009359	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272009360	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272009361	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272009362	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
331272009363	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
331272009364	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
331272009365	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272009366	catalytic loop [active]
331272009367	iron binding site [ion binding]; other site
331272009368	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272009369	Serine hydrolase; Region: Ser_hydrolase; pfam06821
331272009370	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272009371	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
331272009372	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
331272009373	putative ligand binding site [chemical binding]; other site
331272009374	NAD binding site [chemical binding]; other site
331272009375	dimerization interface [polypeptide binding]; other site
331272009376	catalytic site [active]
331272009377	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
331272009378	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
331272009379	active site
331272009380	catalytic residues [active]
331272009381	metal binding site [ion binding]; metal-binding site
331272009382	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
331272009383	putative deacylase active site [active]
331272009384	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
331272009385	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272009386	EamA-like transporter family; Region: EamA; pfam00892
331272009387	EamA-like transporter family; Region: EamA; pfam00892
331272009388	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272009389	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272009390	dimerization interface [polypeptide binding]; other site
331272009391	putative DNA binding site [nucleotide binding]; other site
331272009392	putative Zn2+ binding site [ion binding]; other site
331272009393	AsnC family; Region: AsnC_trans_reg; pfam01037
331272009394	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
331272009395	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
331272009396	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
331272009397	FMN binding site [chemical binding]; other site
331272009398	substrate binding site [chemical binding]; other site
331272009399	putative catalytic residue [active]
331272009400	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272009401	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272009402	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272009403	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272009404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009405	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272009406	putative effector binding pocket; other site
331272009407	dimerization interface [polypeptide binding]; other site
331272009408	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272009409	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272009410	eyelet of channel; other site
331272009411	trimer interface [polypeptide binding]; other site
331272009412	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
331272009413	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
331272009414	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272009415	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
331272009416	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272009417	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272009418	metal binding site [ion binding]; metal-binding site
331272009419	active site
331272009420	I-site; other site
331272009421	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272009422	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272009423	DNA binding site [nucleotide binding]
331272009424	domain linker motif; other site
331272009425	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
331272009426	ligand binding site [chemical binding]; other site
331272009427	dimerization interface [polypeptide binding]; other site
331272009428	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
331272009429	dimerization interface [polypeptide binding]; other site
331272009430	putative active cleft [active]
331272009431	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
331272009432	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272009433	putative substrate binding site [chemical binding]; other site
331272009434	putative ATP binding site [chemical binding]; other site
331272009435	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
331272009436	Uncharacterized conserved protein [Function unknown]; Region: COG1565
331272009437	short chain dehydrogenase; Provisional; Region: PRK09134
331272009438	Dihydroneopterin aldolase; Region: FolB; smart00905
331272009439	active site
331272009440	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
331272009441	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
331272009442	Ligand Binding Site [chemical binding]; other site
331272009443	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
331272009444	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
331272009445	Substrate binding site; other site
331272009446	Mg++ binding site; other site
331272009447	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
331272009448	active site
331272009449	substrate binding site [chemical binding]; other site
331272009450	CoA binding site [chemical binding]; other site
331272009451	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
331272009452	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
331272009453	glutaminase active site [active]
331272009454	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331272009455	dimer interface [polypeptide binding]; other site
331272009456	active site
331272009457	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331272009458	dimer interface [polypeptide binding]; other site
331272009459	active site
331272009460	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
331272009461	Predicted transcriptional regulator [Transcription]; Region: COG2944
331272009462	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272009463	non-specific DNA binding site [nucleotide binding]; other site
331272009464	salt bridge; other site
331272009465	sequence-specific DNA binding site [nucleotide binding]; other site
331272009466	Iron permease FTR1 family; Region: FTR1; cl00475
331272009467	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
331272009468	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331272009469	metal-binding site [ion binding]
331272009470	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
331272009471	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
331272009472	NAD(P) binding site [chemical binding]; other site
331272009473	catalytic residues [active]
331272009474	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272009475	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
331272009476	non-specific DNA binding site [nucleotide binding]; other site
331272009477	salt bridge; other site
331272009478	sequence-specific DNA binding site [nucleotide binding]; other site
331272009479	Cupin domain; Region: Cupin_2; pfam07883
331272009480	Peptidase C26; Region: Peptidase_C26; pfam07722
331272009481	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
331272009482	catalytic triad [active]
331272009483	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
331272009484	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
331272009485	putative aminotransferase; Validated; Region: PRK07480
331272009486	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272009487	inhibitor-cofactor binding pocket; inhibition site
331272009488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272009489	catalytic residue [active]
331272009490	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
331272009491	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272009492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272009493	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
331272009494	Walker A/P-loop; other site
331272009495	ATP binding site [chemical binding]; other site
331272009496	Q-loop/lid; other site
331272009497	ABC transporter signature motif; other site
331272009498	Walker B; other site
331272009499	D-loop; other site
331272009500	H-loop/switch region; other site
331272009501	TOBE domain; Region: TOBE_2; pfam08402
331272009502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009503	dimer interface [polypeptide binding]; other site
331272009504	conserved gate region; other site
331272009505	putative PBP binding loops; other site
331272009506	ABC-ATPase subunit interface; other site
331272009507	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272009508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009509	dimer interface [polypeptide binding]; other site
331272009510	conserved gate region; other site
331272009511	putative PBP binding loops; other site
331272009512	ABC-ATPase subunit interface; other site
331272009513	Protein of unknown function (DUF3138); Region: DUF3138; pfam11336
331272009514	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
331272009515	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272009516	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272009517	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272009518	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272009519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
331272009520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
331272009521	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
331272009522	glutathione reductase; Validated; Region: PRK06116
331272009523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272009524	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272009525	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272009526	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272009527	eyelet of channel; other site
331272009528	trimer interface [polypeptide binding]; other site
331272009529	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
331272009530	Chromate transporter; Region: Chromate_transp; pfam02417
331272009531	Chromate transporter; Region: Chromate_transp; pfam02417
331272009532	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272009533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009534	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272009535	dimerization interface [polypeptide binding]; other site
331272009536	substrate binding pocket [chemical binding]; other site
331272009537	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
331272009538	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
331272009539	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
331272009540	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
331272009541	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
331272009542	Flagellar regulator YcgR; Region: YcgR; pfam07317
331272009543	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
331272009544	PilZ domain; Region: PilZ; pfam07238
331272009545	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709
331272009546	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
331272009547	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
331272009548	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
331272009549	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
331272009550	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697
331272009551	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
331272009552	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
331272009553	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
331272009554	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
331272009555	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
331272009556	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
331272009557	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
331272009558	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
331272009559	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
331272009560	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
331272009561	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
331272009562	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
331272009563	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
331272009564	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
331272009565	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
331272009566	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
331272009567	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
331272009568	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626
331272009569	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
331272009570	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
331272009571	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
331272009572	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
331272009573	FlgN protein; Region: FlgN; pfam05130
331272009574	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
331272009575	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
331272009576	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
331272009577	active site
331272009578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272009579	sequence-specific DNA binding site [nucleotide binding]; other site
331272009580	salt bridge; other site
331272009581	Cupin domain; Region: Cupin_2; pfam07883
331272009582	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
331272009583	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
331272009584	active site
331272009585	NTP binding site [chemical binding]; other site
331272009586	metal binding triad [ion binding]; metal-binding site
331272009587	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
331272009588	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
331272009589	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272009590	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
331272009591	putative C-terminal domain interface [polypeptide binding]; other site
331272009592	putative GSH binding site (G-site) [chemical binding]; other site
331272009593	putative dimer interface [polypeptide binding]; other site
331272009594	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
331272009595	putative N-terminal domain interface [polypeptide binding]; other site
331272009596	putative dimer interface [polypeptide binding]; other site
331272009597	putative substrate binding pocket (H-site) [chemical binding]; other site
331272009598	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
331272009599	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
331272009600	putative NAD(P) binding site [chemical binding]; other site
331272009601	active site
331272009602	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272009603	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272009604	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272009605	catalytic residue [active]
331272009606	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
331272009607	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
331272009608	MarR family; Region: MarR_2; cl17246
331272009609	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272009610	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
331272009611	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
331272009612	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
331272009613	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
331272009614	putative active site [active]
331272009615	TraB family; Region: TraB; pfam01963
331272009616	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
331272009617	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272009618	Walker A/P-loop; other site
331272009619	ATP binding site [chemical binding]; other site
331272009620	Q-loop/lid; other site
331272009621	ABC transporter signature motif; other site
331272009622	Walker B; other site
331272009623	D-loop; other site
331272009624	H-loop/switch region; other site
331272009625	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
331272009626	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
331272009627	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272009628	Walker A/P-loop; other site
331272009629	ATP binding site [chemical binding]; other site
331272009630	Q-loop/lid; other site
331272009631	ABC transporter signature motif; other site
331272009632	Walker B; other site
331272009633	D-loop; other site
331272009634	H-loop/switch region; other site
331272009635	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272009636	dipeptide transporter; Provisional; Region: PRK10913
331272009637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009638	dimer interface [polypeptide binding]; other site
331272009639	conserved gate region; other site
331272009640	putative PBP binding loops; other site
331272009641	ABC-ATPase subunit interface; other site
331272009642	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
331272009643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009644	dimer interface [polypeptide binding]; other site
331272009645	conserved gate region; other site
331272009646	putative PBP binding loops; other site
331272009647	ABC-ATPase subunit interface; other site
331272009648	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
331272009649	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
331272009650	peptide binding site [polypeptide binding]; other site
331272009651	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272009652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272009653	putative substrate translocation pore; other site
331272009654	High potential iron-sulfur protein; Region: HIPIP; pfam01355
331272009655	Predicted dehydrogenase [General function prediction only]; Region: COG0579
331272009656	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272009657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272009658	ATP binding site [chemical binding]; other site
331272009659	Walker B motif; other site
331272009660	arginine finger; other site
331272009661	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
331272009662	putative FMN binding site [chemical binding]; other site
331272009663	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
331272009664	putative catalytic site [active]
331272009665	putative phosphate binding site [ion binding]; other site
331272009666	putative metal binding site [ion binding]; other site
331272009667	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
331272009668	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
331272009669	FAD binding pocket [chemical binding]; other site
331272009670	FAD binding motif [chemical binding]; other site
331272009671	phosphate binding motif [ion binding]; other site
331272009672	beta-alpha-beta structure motif; other site
331272009673	NAD binding pocket [chemical binding]; other site
331272009674	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
331272009675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272009676	ATP binding site [chemical binding]; other site
331272009677	Mg2+ binding site [ion binding]; other site
331272009678	G-X-G motif; other site
331272009679	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272009680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272009681	active site
331272009682	phosphorylation site [posttranslational modification]
331272009683	intermolecular recognition site; other site
331272009684	dimerization interface [polypeptide binding]; other site
331272009685	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272009686	DNA binding residues [nucleotide binding]
331272009687	dimerization interface [polypeptide binding]; other site
331272009688	amino acid transporter; Region: 2A0306; TIGR00909
331272009689	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
331272009690	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
331272009691	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
331272009692	XdhC Rossmann domain; Region: XdhC_C; pfam13478
331272009693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
331272009694	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
331272009695	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
331272009696	Flagellar protein FliT; Region: FliT; cl05125
331272009697	Flagellar protein FliS; Region: FliS; cl00654
331272009698	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
331272009699	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
331272009700	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
331272009701	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
331272009702	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
331272009703	FliG C-terminal domain; Region: FliG_C; pfam01706
331272009704	flagellar assembly protein H; Validated; Region: fliH; PRK05687
331272009705	Flagellar assembly protein FliH; Region: FliH; pfam02108
331272009706	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
331272009707	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
331272009708	Walker A motif/ATP binding site; other site
331272009709	Walker B motif; other site
331272009710	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
331272009711	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
331272009712	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
331272009713	choline dehydrogenase; Validated; Region: PRK02106
331272009714	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272009715	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
331272009716	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
331272009717	NAD(P) binding site [chemical binding]; other site
331272009718	catalytic residues [active]
331272009719	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
331272009720	serine/threonine protein kinase; Provisional; Region: PRK11768
331272009721	EamA-like transporter family; Region: EamA; pfam00892
331272009722	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272009723	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272009724	active site
331272009725	catalytic tetrad [active]
331272009726	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
331272009727	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
331272009728	S-adenosylmethionine synthetase; Validated; Region: PRK05250
331272009729	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
331272009730	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
331272009731	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
331272009732	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
331272009733	putative acyl-acceptor binding pocket; other site
331272009734	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
331272009735	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272009736	sequence-specific DNA binding site [nucleotide binding]; other site
331272009737	salt bridge; other site
331272009738	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
331272009739	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
331272009740	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331272009741	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331272009742	Protein of unknown function, DUF484; Region: DUF484; cl17449
331272009743	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
331272009744	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272009745	active site
331272009746	DNA binding site [nucleotide binding]
331272009747	Int/Topo IB signature motif; other site
331272009748	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
331272009749	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
331272009750	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
331272009751	putative RNA binding site [nucleotide binding]; other site
331272009752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272009753	S-adenosylmethionine binding site [chemical binding]; other site
331272009754	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
331272009755	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
331272009756	P-loop, Walker A motif; other site
331272009757	Base recognition motif; other site
331272009758	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
331272009759	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
331272009760	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
331272009761	active site
331272009762	HslU subunit interaction site [polypeptide binding]; other site
331272009763	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
331272009764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272009765	Walker A motif; other site
331272009766	ATP binding site [chemical binding]; other site
331272009767	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
331272009768	Walker B motif; other site
331272009769	arginine finger; other site
331272009770	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
331272009771	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
331272009772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272009773	active site
331272009774	phosphorylation site [posttranslational modification]
331272009775	intermolecular recognition site; other site
331272009776	dimerization interface [polypeptide binding]; other site
331272009777	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272009778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272009779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272009780	dimer interface [polypeptide binding]; other site
331272009781	phosphorylation site [posttranslational modification]
331272009782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272009783	ATP binding site [chemical binding]; other site
331272009784	Mg2+ binding site [ion binding]; other site
331272009785	G-X-G motif; other site
331272009786	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
331272009787	feedback inhibition sensing region; other site
331272009788	homohexameric interface [polypeptide binding]; other site
331272009789	nucleotide binding site [chemical binding]; other site
331272009790	N-acetyl-L-glutamate binding site [chemical binding]; other site
331272009791	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
331272009792	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
331272009793	division inhibitor protein; Provisional; Region: slmA; PRK09480
331272009794	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272009795	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
331272009796	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
331272009797	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272009798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272009799	S-adenosylmethionine binding site [chemical binding]; other site
331272009800	muropeptide transporter; Reviewed; Region: ampG; PRK11902
331272009801	AmpG-like permease; Region: 2A0125; TIGR00901
331272009802	Peptidase family M48; Region: Peptidase_M48; cl12018
331272009803	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272009804	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272009805	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
331272009806	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
331272009807	putative NAD(P) binding site [chemical binding]; other site
331272009808	putative substrate binding site [chemical binding]; other site
331272009809	catalytic Zn binding site [ion binding]; other site
331272009810	structural Zn binding site [ion binding]; other site
331272009811	dimer interface [polypeptide binding]; other site
331272009812	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
331272009813	putative active site [active]
331272009814	putative catalytic site [active]
331272009815	putative DNA binding site [nucleotide binding]; other site
331272009816	putative phosphate binding site [ion binding]; other site
331272009817	metal binding site A [ion binding]; metal-binding site
331272009818	putative AP binding site [nucleotide binding]; other site
331272009819	putative metal binding site B [ion binding]; other site
331272009820	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
331272009821	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
331272009822	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
331272009823	GatB domain; Region: GatB_Yqey; smart00845
331272009824	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331272009825	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
331272009826	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
331272009827	rod shape-determining protein MreB; Provisional; Region: PRK13927
331272009828	MreB and similar proteins; Region: MreB_like; cd10225
331272009829	nucleotide binding site [chemical binding]; other site
331272009830	Mg binding site [ion binding]; other site
331272009831	putative protofilament interaction site [polypeptide binding]; other site
331272009832	RodZ interaction site [polypeptide binding]; other site
331272009833	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
331272009834	rod shape-determining protein MreC; Region: MreC; pfam04085
331272009835	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
331272009836	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
331272009837	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
331272009838	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
331272009839	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
331272009840	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272009841	Sel1-like repeats; Region: SEL1; smart00671
331272009842	Sel1-like repeats; Region: SEL1; smart00671
331272009843	Sel1-like repeats; Region: SEL1; smart00671
331272009844	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
331272009845	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
331272009846	active site
331272009847	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
331272009848	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
331272009849	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
331272009850	Ligand Binding Site [chemical binding]; other site
331272009851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272009852	Response regulator receiver domain; Region: Response_reg; pfam00072
331272009853	active site
331272009854	phosphorylation site [posttranslational modification]
331272009855	intermolecular recognition site; other site
331272009856	dimerization interface [polypeptide binding]; other site
331272009857	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
331272009858	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272009859	dimerization interface [polypeptide binding]; other site
331272009860	PAS domain; Region: PAS; smart00091
331272009861	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
331272009862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272009863	dimer interface [polypeptide binding]; other site
331272009864	phosphorylation site [posttranslational modification]
331272009865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272009866	ATP binding site [chemical binding]; other site
331272009867	Mg2+ binding site [ion binding]; other site
331272009868	G-X-G motif; other site
331272009869	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
331272009870	16S rRNA methyltransferase B; Provisional; Region: PRK10901
331272009871	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
331272009872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272009873	S-adenosylmethionine binding site [chemical binding]; other site
331272009874	M48 family peptidase; Provisional; Region: PRK03001
331272009875	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272009876	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
331272009877	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
331272009878	putative active site [active]
331272009879	substrate binding site [chemical binding]; other site
331272009880	putative cosubstrate binding site; other site
331272009881	catalytic site [active]
331272009882	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
331272009883	substrate binding site [chemical binding]; other site
331272009884	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
331272009885	active site
331272009886	catalytic residues [active]
331272009887	metal binding site [ion binding]; metal-binding site
331272009888	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
331272009889	DNA protecting protein DprA; Region: dprA; TIGR00732
331272009890	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331272009891	catalytic residues [active]
331272009892	DNA topoisomerase III; Validated; Region: PRK08173
331272009893	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
331272009894	active site
331272009895	putative interdomain interaction site [polypeptide binding]; other site
331272009896	putative metal-binding site [ion binding]; other site
331272009897	putative nucleotide binding site [chemical binding]; other site
331272009898	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
331272009899	domain I; other site
331272009900	DNA binding groove [nucleotide binding]
331272009901	phosphate binding site [ion binding]; other site
331272009902	domain II; other site
331272009903	domain III; other site
331272009904	nucleotide binding site [chemical binding]; other site
331272009905	catalytic site [active]
331272009906	domain IV; other site
331272009907	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
331272009908	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
331272009909	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272009910	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009911	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272009912	putative effector binding pocket; other site
331272009913	dimerization interface [polypeptide binding]; other site
331272009914	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
331272009915	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
331272009916	dimerization interface [polypeptide binding]; other site
331272009917	NAD binding site [chemical binding]; other site
331272009918	ligand binding site [chemical binding]; other site
331272009919	catalytic site [active]
331272009920	Patatin-like phospholipase; Region: Patatin; pfam01734
331272009921	active site
331272009922	nucleophile elbow; other site
331272009923	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
331272009924	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
331272009925	CoenzymeA binding site [chemical binding]; other site
331272009926	subunit interaction site [polypeptide binding]; other site
331272009927	PHB binding site; other site
331272009928	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
331272009929	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
331272009930	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
331272009931	CGNR zinc finger; Region: zf-CGNR; pfam11706
331272009932	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272009933	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272009934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272009935	Walker A/P-loop; other site
331272009936	ATP binding site [chemical binding]; other site
331272009937	Q-loop/lid; other site
331272009938	ABC transporter signature motif; other site
331272009939	Walker B; other site
331272009940	D-loop; other site
331272009941	H-loop/switch region; other site
331272009942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272009943	dimer interface [polypeptide binding]; other site
331272009944	conserved gate region; other site
331272009945	putative PBP binding loops; other site
331272009946	ABC-ATPase subunit interface; other site
331272009947	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272009948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272009949	substrate binding pocket [chemical binding]; other site
331272009950	membrane-bound complex binding site; other site
331272009951	hinge residues; other site
331272009952	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
331272009953	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
331272009954	NAD(P) binding site [chemical binding]; other site
331272009955	catalytic residues [active]
331272009956	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
331272009957	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
331272009958	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272009959	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272009960	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
331272009961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272009962	DNA-binding site [nucleotide binding]; DNA binding site
331272009963	FCD domain; Region: FCD; pfam07729
331272009964	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
331272009965	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272009966	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272009967	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272009968	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272009969	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
331272009970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272009971	dimerization interface [polypeptide binding]; other site
331272009972	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
331272009973	L-lactate permease; Region: Lactate_perm; cl00701
331272009974	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272009975	glutamate--cysteine ligase; Provisional; Region: PRK02107
331272009976	AlkA N-terminal domain; Region: AlkA_N; pfam06029
331272009977	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
331272009978	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
331272009979	minor groove reading motif; other site
331272009980	helix-hairpin-helix signature motif; other site
331272009981	substrate binding pocket [chemical binding]; other site
331272009982	active site
331272009983	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
331272009984	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
331272009985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272009986	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
331272009987	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
331272009988	DNA binding site [nucleotide binding]
331272009989	active site
331272009990	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
331272009991	dimer interface [polypeptide binding]; other site
331272009992	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272009993	metal binding site [ion binding]; metal-binding site
331272009994	YaeQ protein; Region: YaeQ; pfam07152
331272009995	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
331272009996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272009997	Coenzyme A binding pocket [chemical binding]; other site
331272009998	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
331272009999	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272010000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272010001	metal binding site [ion binding]; metal-binding site
331272010002	active site
331272010003	I-site; other site
331272010004	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
331272010005	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
331272010006	trmE is a tRNA modification GTPase; Region: trmE; cd04164
331272010007	G1 box; other site
331272010008	GTP/Mg2+ binding site [chemical binding]; other site
331272010009	Switch I region; other site
331272010010	G2 box; other site
331272010011	Switch II region; other site
331272010012	G3 box; other site
331272010013	G4 box; other site
331272010014	G5 box; other site
331272010015	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
331272010016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272010017	non-specific DNA binding site [nucleotide binding]; other site
331272010018	salt bridge; other site
331272010019	sequence-specific DNA binding site [nucleotide binding]; other site
331272010020	membrane protein insertase; Provisional; Region: PRK01318
331272010021	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
331272010022	hypothetical protein; Validated; Region: PRK00041
331272010023	Ribonuclease P; Region: Ribonuclease_P; cl00457
331272010024	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
331272010025	malate:quinone oxidoreductase; Validated; Region: PRK05257
331272010026	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
331272010027	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272010028	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272010029	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
331272010030	Peptidase family M23; Region: Peptidase_M23; pfam01551
331272010031	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
331272010032	putative heme binding pocket [chemical binding]; other site
331272010033	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
331272010034	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331272010035	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
331272010036	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
331272010037	Autotransporter beta-domain; Region: Autotransporter; smart00869
331272010038	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
331272010039	N-Terminal Domain Of Bc2l-C Lectin; Region: Bc2l-C_N; cd12211
331272010040	trimer interface [polypeptide binding]; other site
331272010041	ligand binding site [chemical binding]; other site
331272010042	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
331272010043	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
331272010044	2-isopropylmalate synthase; Validated; Region: PRK03739
331272010045	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
331272010046	active site
331272010047	catalytic residues [active]
331272010048	metal binding site [ion binding]; metal-binding site
331272010049	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
331272010050	Autoinducer binding domain; Region: Autoind_bind; pfam03472
331272010051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272010052	DNA binding residues [nucleotide binding]
331272010053	dimerization interface [polypeptide binding]; other site
331272010054	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272010055	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272010056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010057	hypothetical protein; Provisional; Region: PRK07481
331272010058	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272010059	inhibitor-cofactor binding pocket; inhibition site
331272010060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272010061	catalytic residue [active]
331272010062	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
331272010063	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
331272010064	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
331272010065	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
331272010066	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
331272010067	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
331272010068	acyl-activating enzyme (AAE) consensus motif; other site
331272010069	AMP binding site [chemical binding]; other site
331272010070	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272010071	thioester reductase domain; Region: Thioester-redct; TIGR01746
331272010072	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
331272010073	putative NAD(P) binding site [chemical binding]; other site
331272010074	active site
331272010075	putative substrate binding site [chemical binding]; other site
331272010076	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
331272010077	putative hydrophobic ligand binding site [chemical binding]; other site
331272010078	protein interface [polypeptide binding]; other site
331272010079	gate; other site
331272010080	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010082	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272010083	putative effector binding pocket; other site
331272010084	dimerization interface [polypeptide binding]; other site
331272010085	Cupin domain; Region: Cupin_2; pfam07883
331272010086	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272010087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010088	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
331272010089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272010090	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
331272010091	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272010092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010093	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272010094	putative substrate translocation pore; other site
331272010095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272010097	dimerization interface [polypeptide binding]; other site
331272010098	putative DNA binding site [nucleotide binding]; other site
331272010099	putative Zn2+ binding site [ion binding]; other site
331272010100	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
331272010101	Low molecular weight phosphatase family; Region: LMWPc; cd00115
331272010102	active site
331272010103	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
331272010104	arsenical-resistance protein; Region: acr3; TIGR00832
331272010105	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
331272010106	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272010107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272010108	dimer interface [polypeptide binding]; other site
331272010109	phosphorylation site [posttranslational modification]
331272010110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272010111	ATP binding site [chemical binding]; other site
331272010112	Mg2+ binding site [ion binding]; other site
331272010113	G-X-G motif; other site
331272010114	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
331272010115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272010116	active site
331272010117	phosphorylation site [posttranslational modification]
331272010118	intermolecular recognition site; other site
331272010119	dimerization interface [polypeptide binding]; other site
331272010120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272010121	DNA binding residues [nucleotide binding]
331272010122	dimerization interface [polypeptide binding]; other site
331272010123	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
331272010124	active site
331272010125	zinc binding site [ion binding]; other site
331272010126	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
331272010127	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
331272010128	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
331272010129	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272010130	Integrase core domain; Region: rve; pfam00665
331272010131	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
331272010132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272010133	Walker A motif; other site
331272010134	ATP binding site [chemical binding]; other site
331272010135	Walker B motif; other site
331272010136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272010137	NAD(P) binding site [chemical binding]; other site
331272010138	active site
331272010139	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
331272010140	EamA-like transporter family; Region: EamA; pfam00892
331272010141	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272010142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010143	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272010144	dimerization interface [polypeptide binding]; other site
331272010145	substrate binding pocket [chemical binding]; other site
331272010146	Helix-turn-helix domain; Region: HTH_17; pfam12728
331272010147	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
331272010148	active site
331272010149	coenzyme A binding site [chemical binding]; other site
331272010150	citrylCoA binding site [chemical binding]; other site
331272010151	dimer interface [polypeptide binding]; other site
331272010152	Citrate synthase; Region: Citrate_synt; pfam00285
331272010153	oxalacetate/citrate binding site [chemical binding]; other site
331272010154	catalytic triad [active]
331272010155	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272010156	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331272010157	active site
331272010158	metal binding site [ion binding]; metal-binding site
331272010159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010160	D-galactonate transporter; Region: 2A0114; TIGR00893
331272010161	putative substrate translocation pore; other site
331272010162	classical (c) SDRs; Region: SDR_c; cd05233
331272010163	NAD(P) binding site [chemical binding]; other site
331272010164	active site
331272010165	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
331272010166	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
331272010167	dimerization interface [polypeptide binding]; other site
331272010168	ligand binding site [chemical binding]; other site
331272010169	NADP binding site [chemical binding]; other site
331272010170	catalytic site [active]
331272010171	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
331272010172	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
331272010173	active site pocket [active]
331272010174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010175	D-galactonate transporter; Region: 2A0114; TIGR00893
331272010176	putative substrate translocation pore; other site
331272010177	short chain dehydrogenase; Validated; Region: PRK08264
331272010178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272010179	NAD(P) binding site [chemical binding]; other site
331272010180	active site
331272010181	YCII-related domain; Region: YCII; pfam03795
331272010182	short chain dehydrogenase; Provisional; Region: PRK06179
331272010183	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272010184	NADP binding site [chemical binding]; other site
331272010185	active site
331272010186	steroid binding site; other site
331272010187	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272010188	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272010189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010190	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272010191	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272010192	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272010193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272010195	putative effector binding pocket; other site
331272010196	dimerization interface [polypeptide binding]; other site
331272010197	short chain dehydrogenase; Provisional; Region: PRK06500
331272010198	classical (c) SDRs; Region: SDR_c; cd05233
331272010199	NAD(P) binding site [chemical binding]; other site
331272010200	active site
331272010201	Pirin-related protein [General function prediction only]; Region: COG1741
331272010202	Pirin; Region: Pirin; pfam02678
331272010203	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272010204	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010205	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010206	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272010207	dimerization interface [polypeptide binding]; other site
331272010208	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272010209	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272010210	inhibitor site; inhibition site
331272010211	active site
331272010212	dimer interface [polypeptide binding]; other site
331272010213	catalytic residue [active]
331272010214	benzoate transport; Region: 2A0115; TIGR00895
331272010215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010216	putative substrate translocation pore; other site
331272010217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010218	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272010219	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272010220	trimer interface [polypeptide binding]; other site
331272010221	eyelet of channel; other site
331272010222	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272010223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010224	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
331272010225	Helix-turn-helix domain; Region: HTH_38; pfam13936
331272010226	Integrase core domain; Region: rve; pfam00665
331272010227	HTH-like domain; Region: HTH_21; pfam13276
331272010228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272010229	Transposase; Region: HTH_Tnp_1; pfam01527
331272010230	hypothetical protein; Provisional; Region: PRK10621
331272010231	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
331272010232	Protein of unknown function, DUF488; Region: DUF488; pfam04343
331272010233	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
331272010234	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272010235	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272010236	trimer interface [polypeptide binding]; other site
331272010237	eyelet of channel; other site
331272010238	benzoate transport; Region: 2A0115; TIGR00895
331272010239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010240	putative substrate translocation pore; other site
331272010241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010242	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272010243	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272010244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010245	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
331272010246	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
331272010247	dimer interface [polypeptide binding]; other site
331272010248	TPP-binding site [chemical binding]; other site
331272010249	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
331272010250	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272010251	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
331272010252	E3 interaction surface; other site
331272010253	lipoyl attachment site [posttranslational modification]; other site
331272010254	e3 binding domain; Region: E3_binding; pfam02817
331272010255	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
331272010256	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272010257	E3 interaction surface; other site
331272010258	lipoyl attachment site [posttranslational modification]; other site
331272010259	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
331272010260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272010261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272010262	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272010263	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272010264	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272010265	putative DNA binding site [nucleotide binding]; other site
331272010266	putative Zn2+ binding site [ion binding]; other site
331272010267	AsnC family; Region: AsnC_trans_reg; pfam01037
331272010268	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
331272010269	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
331272010270	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
331272010271	dimerization interface [polypeptide binding]; other site
331272010272	active site
331272010273	acyl-CoA synthetase; Validated; Region: PRK08162
331272010274	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
331272010275	acyl-activating enzyme (AAE) consensus motif; other site
331272010276	putative active site [active]
331272010277	AMP binding site [chemical binding]; other site
331272010278	putative CoA binding site [chemical binding]; other site
331272010279	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272010280	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272010281	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010282	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
331272010283	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272010284	substrate binding site [chemical binding]; other site
331272010285	oxyanion hole (OAH) forming residues; other site
331272010286	trimer interface [polypeptide binding]; other site
331272010287	Creatinine amidohydrolase; Region: Creatininase; pfam02633
331272010288	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
331272010289	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
331272010290	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
331272010291	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272010292	substrate binding site [chemical binding]; other site
331272010293	oxyanion hole (OAH) forming residues; other site
331272010294	trimer interface [polypeptide binding]; other site
331272010295	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
331272010296	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272010297	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
331272010298	acyl-activating enzyme (AAE) consensus motif; other site
331272010299	putative AMP binding site [chemical binding]; other site
331272010300	putative active site [active]
331272010301	putative CoA binding site [chemical binding]; other site
331272010302	Flavin Reductases; Region: FlaRed; cl00801
331272010303	Winged helix-turn helix; Region: HTH_29; pfam13551
331272010304	Integrase core domain; Region: rve; pfam00665
331272010305	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
331272010306	Bacterial TniB protein; Region: TniB; pfam05621
331272010307	AAA domain; Region: AAA_22; pfam13401
331272010308	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
331272010309	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
331272010310	active site 1 [active]
331272010311	dimer interface [polypeptide binding]; other site
331272010312	hexamer interface [polypeptide binding]; other site
331272010313	active site 2 [active]
331272010314	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
331272010315	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272010316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272010317	homodimer interface [polypeptide binding]; other site
331272010318	catalytic residue [active]
331272010319	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272010320	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272010321	FMN binding site [chemical binding]; other site
331272010322	active site
331272010323	substrate binding site [chemical binding]; other site
331272010324	catalytic residue [active]
331272010325	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
331272010326	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
331272010327	catalytic residues [active]
331272010328	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
331272010329	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272010330	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272010331	OsmC-like protein; Region: OsmC; pfam02566
331272010332	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272010333	classical (c) SDRs; Region: SDR_c; cd05233
331272010334	NAD(P) binding site [chemical binding]; other site
331272010335	active site
331272010336	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
331272010337	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272010338	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331272010339	Amidase; Region: Amidase; cl11426
331272010340	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010341	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272010342	putative substrate translocation pore; other site
331272010343	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
331272010344	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272010345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010346	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
331272010347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272010348	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272010349	Integrase core domain; Region: rve; pfam00665
331272010350	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
331272010351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272010352	Walker A motif; other site
331272010353	ATP binding site [chemical binding]; other site
331272010354	Walker B motif; other site
331272010355	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272010356	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272010357	DNA binding site [nucleotide binding]
331272010358	domain linker motif; other site
331272010359	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
331272010360	dimerization interface [polypeptide binding]; other site
331272010361	ligand binding site [chemical binding]; other site
331272010362	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
331272010363	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272010364	Walker A/P-loop; other site
331272010365	ATP binding site [chemical binding]; other site
331272010366	Q-loop/lid; other site
331272010367	ABC transporter signature motif; other site
331272010368	Walker B; other site
331272010369	D-loop; other site
331272010370	H-loop/switch region; other site
331272010371	TOBE domain; Region: TOBE_2; pfam08402
331272010372	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272010373	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272010374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272010375	dimer interface [polypeptide binding]; other site
331272010376	putative PBP binding loops; other site
331272010377	ABC-ATPase subunit interface; other site
331272010378	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272010379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272010380	dimer interface [polypeptide binding]; other site
331272010381	conserved gate region; other site
331272010382	putative PBP binding loops; other site
331272010383	ABC-ATPase subunit interface; other site
331272010384	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
331272010385	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
331272010386	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
331272010387	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
331272010388	sugar efflux transporter; Region: 2A0120; TIGR00899
331272010389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010390	putative substrate translocation pore; other site
331272010391	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745
331272010392	YCII-related domain; Region: YCII; cl00999
331272010393	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
331272010394	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272010395	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272010396	Homeodomain-like domain; Region: HTH_23; cl17451
331272010397	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272010398	Integrase core domain; Region: rve; pfam00665
331272010399	Integrase core domain; Region: rve_3; pfam13683
331272010400	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
331272010401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272010402	Walker A motif; other site
331272010403	ATP binding site [chemical binding]; other site
331272010404	Walker B motif; other site
331272010405	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
331272010406	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272010407	Integrase core domain; Region: rve; pfam00665
331272010408	Transposase; Region: HTH_Tnp_1; pfam01527
331272010409	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
331272010410	Integrase core domain; Region: rve; pfam00665
331272010411	Integrase core domain; Region: rve_3; pfam13683
331272010412	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
331272010413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272010414	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272010415	Coenzyme A binding pocket [chemical binding]; other site
331272010416	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
331272010417	putative transposase OrfB; Reviewed; Region: PHA02517
331272010418	HTH-like domain; Region: HTH_21; pfam13276
331272010419	Integrase core domain; Region: rve; pfam00665
331272010420	Integrase core domain; Region: rve_3; pfam13683
331272010421	Integrase core domain; Region: rve_3; cl15866
331272010422	Winged helix-turn helix; Region: HTH_29; pfam13551
331272010423	Helix-turn-helix domain; Region: HTH_28; pfam13518
331272010424	Homeodomain-like domain; Region: HTH_32; pfam13565
331272010425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
331272010426	Integrase core domain; Region: rve; pfam00665
331272010427	Integrase core domain; Region: rve_3; pfam13683
331272010428	HTH-like domain; Region: HTH_21; pfam13276
331272010429	Integrase core domain; Region: rve; pfam00665
331272010430	Transposase; Region: HTH_Tnp_1; cl17663
331272010431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272010432	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272010433	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272010434	catalytic residue [active]
331272010435	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
331272010436	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
331272010437	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
331272010438	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
331272010439	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
331272010440	Type IV secretion system proteins; Region: T4SS; pfam07996
331272010441	VirB8 protein; Region: VirB8; pfam04335
331272010442	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
331272010443	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
331272010444	VirB7 interaction site; other site
331272010445	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
331272010446	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
331272010447	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
331272010448	Walker A motif; other site
331272010449	hexamer interface [polypeptide binding]; other site
331272010450	ATP binding site [chemical binding]; other site
331272010451	Walker B motif; other site
331272010452	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
331272010453	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
331272010454	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
331272010455	Walker A motif; other site
331272010456	ATP binding site [chemical binding]; other site
331272010457	Walker B motif; other site
331272010458	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
331272010459	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
331272010460	active site
331272010461	metal binding site [ion binding]; metal-binding site
331272010462	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
331272010463	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
331272010464	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
331272010465	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272010466	catalytic residues [active]
331272010467	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
331272010468	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
331272010469	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
331272010470	oligomeric interface; other site
331272010471	putative active site [active]
331272010472	homodimer interface [polypeptide binding]; other site
331272010473	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
331272010474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272010475	S-adenosylmethionine binding site [chemical binding]; other site
331272010476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272010477	non-specific DNA binding site [nucleotide binding]; other site
331272010478	salt bridge; other site
331272010479	sequence-specific DNA binding site [nucleotide binding]; other site
331272010480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272010481	Coenzyme A binding pocket [chemical binding]; other site
331272010482	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
331272010483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272010484	Walker A/P-loop; other site
331272010485	ATP binding site [chemical binding]; other site
331272010486	Q-loop/lid; other site
331272010487	ABC transporter signature motif; other site
331272010488	Walker B; other site
331272010489	D-loop; other site
331272010490	H-loop/switch region; other site
331272010491	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272010492	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272010493	active site
331272010494	catalytic tetrad [active]
331272010495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010497	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272010498	putative effector binding pocket; other site
331272010499	dimerization interface [polypeptide binding]; other site
331272010500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272010501	dimerization interface [polypeptide binding]; other site
331272010502	putative DNA binding site [nucleotide binding]; other site
331272010503	putative Zn2+ binding site [ion binding]; other site
331272010504	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272010505	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272010506	catalytic residue [active]
331272010507	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
331272010508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010509	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272010510	dimerization interface [polypeptide binding]; other site
331272010511	allantoate amidohydrolase; Reviewed; Region: PRK12892
331272010512	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
331272010513	active site
331272010514	metal binding site [ion binding]; metal-binding site
331272010515	dimer interface [polypeptide binding]; other site
331272010516	Cupin domain; Region: Cupin_2; cl17218
331272010517	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
331272010518	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
331272010519	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
331272010520	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
331272010521	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
331272010522	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
331272010523	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
331272010524	putative active site [active]
331272010525	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
331272010526	classical (c) SDRs; Region: SDR_c; cd05233
331272010527	NAD(P) binding site [chemical binding]; other site
331272010528	active site
331272010529	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
331272010530	Predicted membrane protein [Function unknown]; Region: COG4541
331272010531	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
331272010532	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272010533	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272010534	putative DNA binding site [nucleotide binding]; other site
331272010535	putative Zn2+ binding site [ion binding]; other site
331272010536	AsnC family; Region: AsnC_trans_reg; pfam01037
331272010537	hypothetical protein; Provisional; Region: PRK11470
331272010538	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272010539	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
331272010540	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
331272010541	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
331272010542	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
331272010543	catalytic residues [active]
331272010544	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
331272010545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272010546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272010547	dimer interface [polypeptide binding]; other site
331272010548	phosphorylation site [posttranslational modification]
331272010549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272010550	ATP binding site [chemical binding]; other site
331272010551	Mg2+ binding site [ion binding]; other site
331272010552	G-X-G motif; other site
331272010553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272010554	Response regulator receiver domain; Region: Response_reg; pfam00072
331272010555	active site
331272010556	phosphorylation site [posttranslational modification]
331272010557	intermolecular recognition site; other site
331272010558	dimerization interface [polypeptide binding]; other site
331272010559	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
331272010560	BetR domain; Region: BetR; pfam08667
331272010561	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
331272010562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272010563	active site
331272010564	phosphorylation site [posttranslational modification]
331272010565	intermolecular recognition site; other site
331272010566	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272010567	Sel1-like repeats; Region: SEL1; smart00671
331272010568	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
331272010569	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
331272010570	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
331272010571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272010572	catalytic residue [active]
331272010573	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272010574	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272010575	putative DNA binding site [nucleotide binding]; other site
331272010576	putative Zn2+ binding site [ion binding]; other site
331272010577	AsnC family; Region: AsnC_trans_reg; pfam01037
331272010578	pyruvate dehydrogenase; Provisional; Region: PRK09124
331272010579	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
331272010580	PYR/PP interface [polypeptide binding]; other site
331272010581	tetramer interface [polypeptide binding]; other site
331272010582	dimer interface [polypeptide binding]; other site
331272010583	TPP binding site [chemical binding]; other site
331272010584	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272010585	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
331272010586	TPP-binding site [chemical binding]; other site
331272010587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272010588	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272010589	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
331272010590	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010592	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272010593	dimerization interface [polypeptide binding]; other site
331272010594	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
331272010595	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
331272010596	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
331272010597	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010598	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
331272010599	dimerization interface [polypeptide binding]; other site
331272010600	Probable transposase; Region: OrfB_IS605; pfam01385
331272010601	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272010602	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272010603	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
331272010604	active site clefts [active]
331272010605	zinc binding site [ion binding]; other site
331272010606	dimer interface [polypeptide binding]; other site
331272010607	cyanate hydratase; Validated; Region: PRK02866
331272010608	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
331272010609	oligomer interface [polypeptide binding]; other site
331272010610	active site
331272010611	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272010612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272010613	Coenzyme A binding pocket [chemical binding]; other site
331272010614	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010616	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272010617	putative dimerization interface [polypeptide binding]; other site
331272010618	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
331272010619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272010620	S-adenosylmethionine binding site [chemical binding]; other site
331272010621	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272010622	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272010623	Coenzyme A binding pocket [chemical binding]; other site
331272010624	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272010625	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272010626	DNA binding residues [nucleotide binding]
331272010627	dimerization interface [polypeptide binding]; other site
331272010628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010629	D-galactonate transporter; Region: 2A0114; TIGR00893
331272010630	putative substrate translocation pore; other site
331272010631	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272010632	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272010633	glutathionine S-transferase; Provisional; Region: PRK10542
331272010634	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
331272010635	C-terminal domain interface [polypeptide binding]; other site
331272010636	GSH binding site (G-site) [chemical binding]; other site
331272010637	dimer interface [polypeptide binding]; other site
331272010638	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
331272010639	dimer interface [polypeptide binding]; other site
331272010640	N-terminal domain interface [polypeptide binding]; other site
331272010641	substrate binding pocket (H-site) [chemical binding]; other site
331272010642	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
331272010643	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
331272010644	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272010645	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
331272010646	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
331272010647	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
331272010648	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
331272010649	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
331272010650	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
331272010651	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
331272010652	putative metal binding site [ion binding]; other site
331272010653	putative homodimer interface [polypeptide binding]; other site
331272010654	putative homotetramer interface [polypeptide binding]; other site
331272010655	putative homodimer-homodimer interface [polypeptide binding]; other site
331272010656	putative allosteric switch controlling residues; other site
331272010657	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
331272010658	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
331272010659	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
331272010660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272010662	putative substrate translocation pore; other site
331272010663	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
331272010664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272010665	dimerization interface [polypeptide binding]; other site
331272010666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272010667	dimer interface [polypeptide binding]; other site
331272010668	phosphorylation site [posttranslational modification]
331272010669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272010670	ATP binding site [chemical binding]; other site
331272010671	Mg2+ binding site [ion binding]; other site
331272010672	G-X-G motif; other site
331272010673	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
331272010674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272010675	active site
331272010676	phosphorylation site [posttranslational modification]
331272010677	intermolecular recognition site; other site
331272010678	dimerization interface [polypeptide binding]; other site
331272010679	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272010680	DNA binding site [nucleotide binding]
331272010681	Outer membrane efflux protein; Region: OEP; pfam02321
331272010682	Outer membrane efflux protein; Region: OEP; pfam02321
331272010683	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
331272010684	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
331272010685	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
331272010686	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
331272010687	CopC domain; Region: CopC; pfam04234
331272010688	Copper resistance protein D; Region: CopD; cl00563
331272010689	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
331272010690	generic binding surface I; other site
331272010691	generic binding surface II; other site
331272010692	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
331272010693	putative active site [active]
331272010694	putative catalytic site [active]
331272010695	putative Mg binding site IVb [ion binding]; other site
331272010696	putative phosphate binding site [ion binding]; other site
331272010697	putative DNA binding site [nucleotide binding]; other site
331272010698	putative Mg binding site IVa [ion binding]; other site
331272010699	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
331272010700	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
331272010701	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272010702	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272010703	conserved cys residue [active]
331272010704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010706	DJ-1 family protein; Region: not_thiJ; TIGR01383
331272010707	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
331272010708	conserved cys residue [active]
331272010709	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272010710	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
331272010711	NAD(P) binding site [chemical binding]; other site
331272010712	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
331272010713	salt bridge; other site
331272010714	non-specific DNA binding site [nucleotide binding]; other site
331272010715	sequence-specific DNA binding site [nucleotide binding]; other site
331272010716	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272010717	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
331272010718	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272010719	catalytic residue [active]
331272010720	Putative phosphatase (DUF442); Region: DUF442; cl17385
331272010721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010722	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272010723	putative substrate translocation pore; other site
331272010724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272010725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010726	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272010727	putative effector binding pocket; other site
331272010728	dimerization interface [polypeptide binding]; other site
331272010729	3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399
331272010730	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272010731	Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115
331272010732	NAD(P) binding site [chemical binding]; other site
331272010733	catalytic residues [active]
331272010734	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
331272010735	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
331272010736	active site
331272010737	dimer interface [polypeptide binding]; other site
331272010738	metal binding site [ion binding]; metal-binding site
331272010739	YciI-like protein; Reviewed; Region: PRK12863
331272010740	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
331272010741	iron-sulfur cluster [ion binding]; other site
331272010742	[2Fe-2S] cluster binding site [ion binding]; other site
331272010743	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272010744	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272010745	trimer interface [polypeptide binding]; other site
331272010746	eyelet of channel; other site
331272010747	MltA-interacting protein MipA; Region: MipA; cl01504
331272010748	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272010749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272010750	active site
331272010751	phosphorylation site [posttranslational modification]
331272010752	intermolecular recognition site; other site
331272010753	dimerization interface [polypeptide binding]; other site
331272010754	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272010755	DNA binding site [nucleotide binding]
331272010756	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
331272010757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272010758	dimerization interface [polypeptide binding]; other site
331272010759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272010760	dimer interface [polypeptide binding]; other site
331272010761	phosphorylation site [posttranslational modification]
331272010762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272010763	ATP binding site [chemical binding]; other site
331272010764	Mg2+ binding site [ion binding]; other site
331272010765	G-X-G motif; other site
331272010766	HTH-like domain; Region: HTH_21; pfam13276
331272010767	Integrase core domain; Region: rve; pfam00665
331272010768	Integrase core domain; Region: rve_3; pfam13683
331272010769	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331272010770	DNA-binding interface [nucleotide binding]; DNA binding site
331272010771	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
331272010772	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
331272010773	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
331272010774	glutaminase active site [active]
331272010775	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331272010776	dimer interface [polypeptide binding]; other site
331272010777	active site
331272010778	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331272010779	dimer interface [polypeptide binding]; other site
331272010780	active site
331272010781	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272010782	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272010783	putative DNA binding site [nucleotide binding]; other site
331272010784	putative Zn2+ binding site [ion binding]; other site
331272010785	AsnC family; Region: AsnC_trans_reg; pfam01037
331272010786	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
331272010787	oligomerization interface [polypeptide binding]; other site
331272010788	active site
331272010789	metal binding site [ion binding]; metal-binding site
331272010790	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272010791	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272010792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010793	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
331272010794	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
331272010795	DNA binding site [nucleotide binding]
331272010796	active site
331272010797	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
331272010798	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
331272010799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272010801	AlkA N-terminal domain; Region: AlkA_N; pfam06029
331272010802	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
331272010803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272010804	D-galactonate transporter; Region: 2A0114; TIGR00893
331272010805	putative substrate translocation pore; other site
331272010806	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272010807	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272010808	DNA binding site [nucleotide binding]
331272010809	domain linker motif; other site
331272010810	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
331272010811	dimerization interface [polypeptide binding]; other site
331272010812	ligand binding site [chemical binding]; other site
331272010813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272010814	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272010815	NAD(P) binding site [chemical binding]; other site
331272010816	active site
331272010817	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
331272010818	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
331272010819	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331272010820	DNA binding residues [nucleotide binding]
331272010821	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272010822	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
331272010823	putative active site [active]
331272010824	putative FMN binding site [chemical binding]; other site
331272010825	putative substrate binding site [chemical binding]; other site
331272010826	putative catalytic residue [active]
331272010827	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272010828	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272010829	N-terminal plug; other site
331272010830	ligand-binding site [chemical binding]; other site
331272010831	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
331272010832	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
331272010833	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
331272010834	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272010835	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
331272010836	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
331272010837	tetrameric interface [polypeptide binding]; other site
331272010838	activator binding site; other site
331272010839	NADP binding site [chemical binding]; other site
331272010840	substrate binding site [chemical binding]; other site
331272010841	catalytic residues [active]
331272010842	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331272010843	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331272010844	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
331272010845	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331272010846	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331272010847	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
331272010848	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272010849	N-terminal plug; other site
331272010850	ligand-binding site [chemical binding]; other site
331272010851	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272010852	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010853	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272010854	dimerization interface [polypeptide binding]; other site
331272010855	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
331272010856	CsbD-like; Region: CsbD; cl17424
331272010857	outer membrane lipoprotein; Provisional; Region: PRK11023
331272010858	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
331272010859	PAS domain; Region: PAS_9; pfam13426
331272010860	PAS domain S-box; Region: sensory_box; TIGR00229
331272010861	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272010862	putative active site [active]
331272010863	heme pocket [chemical binding]; other site
331272010864	PAS domain S-box; Region: sensory_box; TIGR00229
331272010865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272010866	putative active site [active]
331272010867	heme pocket [chemical binding]; other site
331272010868	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272010869	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272010870	DNA binding residues [nucleotide binding]
331272010871	dimerization interface [polypeptide binding]; other site
331272010872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
331272010873	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272010874	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272010875	CsbD-like; Region: CsbD; pfam05532
331272010876	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272010877	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272010878	dimerization interface [polypeptide binding]; other site
331272010879	ligand binding site [chemical binding]; other site
331272010880	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272010881	Beta-lactamase; Region: Beta-lactamase; pfam00144
331272010882	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331272010883	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
331272010884	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272010885	catalytic residue [active]
331272010886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
331272010887	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
331272010888	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
331272010889	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
331272010890	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
331272010891	dimer interface [polypeptide binding]; other site
331272010892	putative functional site; other site
331272010893	putative MPT binding site; other site
331272010894	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
331272010895	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272010896	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272010897	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272010898	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272010899	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
331272010900	putative C-terminal domain interface [polypeptide binding]; other site
331272010901	putative GSH binding site (G-site) [chemical binding]; other site
331272010902	putative dimer interface [polypeptide binding]; other site
331272010903	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
331272010904	putative N-terminal domain interface [polypeptide binding]; other site
331272010905	putative dimer interface [polypeptide binding]; other site
331272010906	putative substrate binding pocket (H-site) [chemical binding]; other site
331272010907	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
331272010908	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
331272010909	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272010910	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272010911	active site
331272010912	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
331272010913	putative deacylase active site [active]
331272010914	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
331272010915	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
331272010916	acyl-activating enzyme (AAE) consensus motif; other site
331272010917	AMP binding site [chemical binding]; other site
331272010918	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
331272010919	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272010920	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
331272010921	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272010922	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272010923	dimerization interface [polypeptide binding]; other site
331272010924	ligand binding site [chemical binding]; other site
331272010925	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272010926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272010927	DNA-binding site [nucleotide binding]; DNA binding site
331272010928	FCD domain; Region: FCD; pfam07729
331272010929	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
331272010930	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010931	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272010932	dimerization interface [polypeptide binding]; other site
331272010933	malic enzyme; Reviewed; Region: PRK12861
331272010934	Malic enzyme, N-terminal domain; Region: malic; pfam00390
331272010935	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
331272010936	putative NAD(P) binding site [chemical binding]; other site
331272010937	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
331272010938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272010939	Walker A motif; other site
331272010940	ATP binding site [chemical binding]; other site
331272010941	Walker B motif; other site
331272010942	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
331272010943	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272010944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272010945	homodimer interface [polypeptide binding]; other site
331272010946	catalytic residue [active]
331272010947	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
331272010948	Uncharacterized conserved protein [Function unknown]; Region: COG5135
331272010949	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272010950	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272010951	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272010952	dimerization interface [polypeptide binding]; other site
331272010953	substrate binding pocket [chemical binding]; other site
331272010954	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
331272010955	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
331272010956	putative NAD(P) binding site [chemical binding]; other site
331272010957	putative active site [active]
331272010958	Epoxide hydrolase N terminus; Region: EHN; pfam06441
331272010959	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272010960	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272010961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272010962	DNA-binding site [nucleotide binding]; DNA binding site
331272010963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272010964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272010965	homodimer interface [polypeptide binding]; other site
331272010966	catalytic residue [active]
331272010967	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
331272010968	homodimer interface [polypeptide binding]; other site
331272010969	catalytic residues [active]
331272010970	NAD binding site [chemical binding]; other site
331272010971	substrate binding pocket [chemical binding]; other site
331272010972	flexible flap; other site
331272010973	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272010974	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272010975	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
331272010976	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272010977	amidase; Provisional; Region: PRK07487
331272010978	Amidase; Region: Amidase; cl11426
331272010979	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
331272010980	active site residue [active]
331272010981	serine O-acetyltransferase; Region: cysE; TIGR01172
331272010982	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
331272010983	trimer interface [polypeptide binding]; other site
331272010984	active site
331272010985	substrate binding site [chemical binding]; other site
331272010986	CoA binding site [chemical binding]; other site
331272010987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272010988	non-specific DNA binding site [nucleotide binding]; other site
331272010989	salt bridge; other site
331272010990	sequence-specific DNA binding site [nucleotide binding]; other site
331272010991	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
331272010992	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
331272010993	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272010994	catalytic residue [active]
331272010995	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
331272010996	nucleotide binding site [chemical binding]; other site
331272010997	substrate binding site [chemical binding]; other site
331272010998	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
331272010999	active site
331272011000	phosphorylation site [posttranslational modification]
331272011001	LysE type translocator; Region: LysE; cl00565
331272011002	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331272011003	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331272011004	ring oligomerisation interface [polypeptide binding]; other site
331272011005	ATP/Mg binding site [chemical binding]; other site
331272011006	stacking interactions; other site
331272011007	hinge regions; other site
331272011008	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
331272011009	oligomerisation interface [polypeptide binding]; other site
331272011010	mobile loop; other site
331272011011	roof hairpin; other site
331272011012	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331272011013	Secretory lipase; Region: LIP; pfam03583
331272011014	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
331272011015	active site
331272011016	Zn2+ binding site [ion binding]; other site
331272011017	intersubunit interface [polypeptide binding]; other site
331272011018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272011019	Walker A motif; other site
331272011020	ATP binding site [chemical binding]; other site
331272011021	Walker B motif; other site
331272011022	arginine finger; other site
331272011023	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272011024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272011025	putative PBP binding loops; other site
331272011026	dimer interface [polypeptide binding]; other site
331272011027	ABC-ATPase subunit interface; other site
331272011028	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272011029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
331272011030	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272011031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272011032	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272011033	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
331272011034	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272011035	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272011036	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
331272011037	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
331272011038	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
331272011039	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
331272011040	TolR protein; Region: tolR; TIGR02801
331272011041	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272011042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011043	putative substrate translocation pore; other site
331272011044	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272011045	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
331272011046	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272011047	N-terminal plug; other site
331272011048	ligand-binding site [chemical binding]; other site
331272011049	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
331272011050	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272011051	putative NAD(P) binding site [chemical binding]; other site
331272011052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011054	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
331272011055	putative effector binding pocket; other site
331272011056	putative dimerization interface [polypeptide binding]; other site
331272011057	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272011058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011059	putative substrate translocation pore; other site
331272011060	short chain dehydrogenase; Provisional; Region: PRK07577
331272011061	classical (c) SDRs; Region: SDR_c; cd05233
331272011062	NAD(P) binding site [chemical binding]; other site
331272011063	active site
331272011064	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
331272011065	Sulfatase; Region: Sulfatase; cl17466
331272011066	Sulfatase; Region: Sulfatase; cl17466
331272011067	Sulfatase; Region: Sulfatase; cl17466
331272011068	Uncharacterized conserved protein [Function unknown]; Region: COG1262
331272011069	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
331272011070	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
331272011071	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
331272011072	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272011075	dimerization interface [polypeptide binding]; other site
331272011076	hypothetical protein; Provisional; Region: PRK05463
331272011077	benzoate transport; Region: 2A0115; TIGR00895
331272011078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011079	putative substrate translocation pore; other site
331272011080	5-oxoprolinase; Region: PLN02666
331272011081	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
331272011082	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
331272011083	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
331272011084	RNase II stability modulator; Provisional; Region: PRK10060
331272011085	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272011086	metal binding site [ion binding]; metal-binding site
331272011087	active site
331272011088	I-site; other site
331272011089	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272011090	enoyl-CoA hydratase; Validated; Region: PRK08788
331272011091	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272011092	substrate binding site [chemical binding]; other site
331272011093	oxyanion hole (OAH) forming residues; other site
331272011094	trimer interface [polypeptide binding]; other site
331272011095	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
331272011096	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
331272011097	Cupin; Region: Cupin_6; pfam12852
331272011098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011099	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272011100	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011102	putative substrate translocation pore; other site
331272011103	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272011104	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272011105	active site
331272011106	catalytic tetrad [active]
331272011107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011109	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272011110	putative effector binding pocket; other site
331272011111	putative dimerization interface [polypeptide binding]; other site
331272011112	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272011113	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
331272011114	tetramer interface [polypeptide binding]; other site
331272011115	active site
331272011116	Mg2+/Mn2+ binding site [ion binding]; other site
331272011117	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272011118	MarR family; Region: MarR; pfam01047
331272011119	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272011120	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
331272011121	dimer interface [polypeptide binding]; other site
331272011122	N-terminal domain interface [polypeptide binding]; other site
331272011123	putative substrate binding pocket (H-site) [chemical binding]; other site
331272011124	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
331272011125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272011126	motif II; other site
331272011127	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
331272011128	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
331272011129	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
331272011130	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
331272011131	dimer interface [polypeptide binding]; other site
331272011132	active site
331272011133	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272011134	substrate binding site [chemical binding]; other site
331272011135	catalytic residue [active]
331272011136	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011138	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272011139	dimerization interface [polypeptide binding]; other site
331272011140	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
331272011141	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272011142	Predicted transcriptional regulator [Transcription]; Region: COG1959
331272011143	Transcriptional regulator; Region: Rrf2; pfam02082
331272011144	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
331272011145	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
331272011146	nucleotide binding site [chemical binding]; other site
331272011147	putative NEF/HSP70 interaction site [polypeptide binding]; other site
331272011148	SBD interface [polypeptide binding]; other site
331272011149	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
331272011150	nucleotide binding site [chemical binding]; other site
331272011151	putative NEF/HSP70 interaction site [polypeptide binding]; other site
331272011152	SBD interface [polypeptide binding]; other site
331272011153	DNA-K related protein; Region: DUF3731; pfam12531
331272011154	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
331272011155	Amidinotransferase; Region: Amidinotransf; pfam02274
331272011156	ornithine cyclodeaminase; Validated; Region: PRK07589
331272011157	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
331272011158	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272011159	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
331272011160	putative DNA binding site [nucleotide binding]; other site
331272011161	putative Zn2+ binding site [ion binding]; other site
331272011162	AsnC family; Region: AsnC_trans_reg; pfam01037
331272011163	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272011164	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
331272011165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
331272011166	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
331272011167	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
331272011168	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272011169	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272011172	dimerization interface [polypeptide binding]; other site
331272011173	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272011174	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349
331272011175	putative ligand binding site [chemical binding]; other site
331272011176	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272011177	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272011178	TM-ABC transporter signature motif; other site
331272011179	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272011180	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272011181	TM-ABC transporter signature motif; other site
331272011182	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272011183	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272011184	Walker A/P-loop; other site
331272011185	ATP binding site [chemical binding]; other site
331272011186	Q-loop/lid; other site
331272011187	ABC transporter signature motif; other site
331272011188	Walker B; other site
331272011189	D-loop; other site
331272011190	H-loop/switch region; other site
331272011191	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272011192	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272011193	Walker A/P-loop; other site
331272011194	ATP binding site [chemical binding]; other site
331272011195	Q-loop/lid; other site
331272011196	ABC transporter signature motif; other site
331272011197	Walker B; other site
331272011198	D-loop; other site
331272011199	H-loop/switch region; other site
331272011200	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
331272011201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272011202	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
331272011203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272011204	dimer interface [polypeptide binding]; other site
331272011205	phosphorylation site [posttranslational modification]
331272011206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272011207	ATP binding site [chemical binding]; other site
331272011208	Mg2+ binding site [ion binding]; other site
331272011209	G-X-G motif; other site
331272011210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272011211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011212	active site
331272011213	phosphorylation site [posttranslational modification]
331272011214	intermolecular recognition site; other site
331272011215	dimerization interface [polypeptide binding]; other site
331272011216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272011217	DNA binding site [nucleotide binding]
331272011218	NMT1-like family; Region: NMT1_2; pfam13379
331272011219	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272011220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011221	D-galactonate transporter; Region: 2A0114; TIGR00893
331272011222	putative substrate translocation pore; other site
331272011223	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
331272011224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
331272011225	Histidine kinase; Region: HisKA_3; pfam07730
331272011226	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272011227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011228	active site
331272011229	phosphorylation site [posttranslational modification]
331272011230	intermolecular recognition site; other site
331272011231	dimerization interface [polypeptide binding]; other site
331272011232	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272011233	DNA binding residues [nucleotide binding]
331272011234	dimerization interface [polypeptide binding]; other site
331272011235	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
331272011236	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
331272011237	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
331272011238	active site
331272011239	LssY C-terminus; Region: LssY_C; pfam14067
331272011240	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
331272011241	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
331272011242	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
331272011243	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
331272011244	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272011245	choline dehydrogenase; Validated; Region: PRK02106
331272011246	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272011247	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272011248	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272011249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011250	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272011251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272011252	Coenzyme A binding pocket [chemical binding]; other site
331272011253	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272011254	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272011255	putative DNA binding site [nucleotide binding]; other site
331272011256	putative Zn2+ binding site [ion binding]; other site
331272011257	AsnC family; Region: AsnC_trans_reg; pfam01037
331272011258	Serine hydrolase; Region: Ser_hydrolase; pfam06821
331272011259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011260	putative substrate translocation pore; other site
331272011261	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272011262	Flavin Reductases; Region: FlaRed; cl00801
331272011263	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
331272011264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011265	active site
331272011266	phosphorylation site [posttranslational modification]
331272011267	intermolecular recognition site; other site
331272011268	dimerization interface [polypeptide binding]; other site
331272011269	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272011270	DNA binding residues [nucleotide binding]
331272011271	dimerization interface [polypeptide binding]; other site
331272011272	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
331272011273	classical (c) SDRs; Region: SDR_c; cd05233
331272011274	NAD(P) binding site [chemical binding]; other site
331272011275	active site
331272011276	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331272011277	Amidase; Region: Amidase; cl11426
331272011278	SnoaL-like domain; Region: SnoaL_4; pfam13577
331272011279	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272011280	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272011281	active site
331272011282	PAS domain; Region: PAS_9; pfam13426
331272011283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
331272011284	putative active site [active]
331272011285	heme pocket [chemical binding]; other site
331272011286	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331272011287	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272011288	putative active site [active]
331272011289	heme pocket [chemical binding]; other site
331272011290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272011291	dimer interface [polypeptide binding]; other site
331272011292	phosphorylation site [posttranslational modification]
331272011293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272011294	ATP binding site [chemical binding]; other site
331272011295	Mg2+ binding site [ion binding]; other site
331272011296	G-X-G motif; other site
331272011297	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
331272011298	active site 1 [active]
331272011299	dimer interface [polypeptide binding]; other site
331272011300	hexamer interface [polypeptide binding]; other site
331272011301	active site 2 [active]
331272011302	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
331272011303	active site 1 [active]
331272011304	dimer interface [polypeptide binding]; other site
331272011305	hexamer interface [polypeptide binding]; other site
331272011306	active site 2 [active]
331272011307	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
331272011308	inter-subunit interface; other site
331272011309	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272011310	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272011311	[2Fe-2S] cluster binding site [ion binding]; other site
331272011312	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
331272011313	putative alpha subunit interface [polypeptide binding]; other site
331272011314	putative active site [active]
331272011315	putative substrate binding site [chemical binding]; other site
331272011316	Fe binding site [ion binding]; other site
331272011317	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
331272011318	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011319	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
331272011320	substrate binding pocket [chemical binding]; other site
331272011321	dimerization interface [polypeptide binding]; other site
331272011322	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
331272011323	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
331272011324	FMN-binding pocket [chemical binding]; other site
331272011325	flavin binding motif; other site
331272011326	phosphate binding motif [ion binding]; other site
331272011327	beta-alpha-beta structure motif; other site
331272011328	NAD binding pocket [chemical binding]; other site
331272011329	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272011330	catalytic loop [active]
331272011331	iron binding site [ion binding]; other site
331272011332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011333	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272011334	putative substrate translocation pore; other site
331272011335	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272011336	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272011337	trimer interface [polypeptide binding]; other site
331272011338	eyelet of channel; other site
331272011339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272011342	dimerization interface [polypeptide binding]; other site
331272011343	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272011344	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331272011345	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
331272011346	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272011347	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269
331272011348	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272011349	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272011350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011351	putative substrate translocation pore; other site
331272011352	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272011353	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272011354	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272011355	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
331272011356	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272011357	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
331272011358	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
331272011359	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272011360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272011361	dimer interface [polypeptide binding]; other site
331272011362	conserved gate region; other site
331272011363	putative PBP binding loops; other site
331272011364	ABC-ATPase subunit interface; other site
331272011365	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
331272011366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272011367	dimer interface [polypeptide binding]; other site
331272011368	conserved gate region; other site
331272011369	putative PBP binding loops; other site
331272011370	ABC-ATPase subunit interface; other site
331272011371	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272011372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272011373	Walker A/P-loop; other site
331272011374	ATP binding site [chemical binding]; other site
331272011375	Q-loop/lid; other site
331272011376	ABC transporter signature motif; other site
331272011377	Walker B; other site
331272011378	D-loop; other site
331272011379	H-loop/switch region; other site
331272011380	TOBE domain; Region: TOBE_2; pfam08402
331272011381	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272011382	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272011383	dimerization interface [polypeptide binding]; other site
331272011384	putative Zn2+ binding site [ion binding]; other site
331272011385	putative DNA binding site [nucleotide binding]; other site
331272011386	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272011387	short chain dehydrogenase; Provisional; Region: PRK06500
331272011388	classical (c) SDRs; Region: SDR_c; cd05233
331272011389	NAD(P) binding site [chemical binding]; other site
331272011390	active site
331272011391	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272011392	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
331272011393	conserved cys residue [active]
331272011394	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
331272011395	SnoaL-like domain; Region: SnoaL_3; pfam13474
331272011396	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272011397	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272011398	conserved cys residue [active]
331272011399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011400	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
331272011401	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272011402	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272011403	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272011404	salt bridge; other site
331272011405	non-specific DNA binding site [nucleotide binding]; other site
331272011406	sequence-specific DNA binding site [nucleotide binding]; other site
331272011407	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
331272011408	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272011409	putative NAD(P) binding site [chemical binding]; other site
331272011410	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
331272011411	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272011412	putative NAD(P) binding site [chemical binding]; other site
331272011413	transcriptional regulator; Provisional; Region: PRK10632
331272011414	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011415	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272011416	putative effector binding pocket; other site
331272011417	putative dimerization interface [polypeptide binding]; other site
331272011418	mercuric reductase; Validated; Region: PRK06370
331272011419	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272011420	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272011421	Transposase; Region: DEDD_Tnp_IS110; pfam01548
331272011422	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272011423	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272011424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272011425	Coenzyme A binding pocket [chemical binding]; other site
331272011426	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272011427	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
331272011428	Domain of unknown function (DUF802); Region: DUF802; pfam05650
331272011429	Domain of unknown function (DUF802); Region: DUF802; pfam05650
331272011430	hypothetical protein; Provisional; Region: PRK09040
331272011431	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272011432	ligand binding site [chemical binding]; other site
331272011433	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
331272011434	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272011435	Predicted flavoprotein [General function prediction only]; Region: COG0431
331272011436	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
331272011437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011438	putative substrate translocation pore; other site
331272011439	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272011440	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272011441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272011442	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
331272011443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
331272011444	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272011445	short chain dehydrogenase; Provisional; Region: PRK05650
331272011446	NAD(P) binding site [chemical binding]; other site
331272011447	active site
331272011448	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272011449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272011450	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
331272011451	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011453	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272011454	putative effector binding pocket; other site
331272011455	dimerization interface [polypeptide binding]; other site
331272011456	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
331272011457	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272011458	putative C-terminal domain interface [polypeptide binding]; other site
331272011459	putative GSH binding site (G-site) [chemical binding]; other site
331272011460	putative dimer interface [polypeptide binding]; other site
331272011461	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
331272011462	putative N-terminal domain interface [polypeptide binding]; other site
331272011463	putative dimer interface [polypeptide binding]; other site
331272011464	putative substrate binding pocket (H-site) [chemical binding]; other site
331272011465	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
331272011466	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
331272011467	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
331272011468	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
331272011469	FAD binding pocket [chemical binding]; other site
331272011470	FAD binding motif [chemical binding]; other site
331272011471	phosphate binding motif [ion binding]; other site
331272011472	beta-alpha-beta structure motif; other site
331272011473	NAD binding pocket [chemical binding]; other site
331272011474	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272011475	catalytic loop [active]
331272011476	iron binding site [ion binding]; other site
331272011477	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
331272011478	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272011479	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272011480	N-terminal plug; other site
331272011481	ligand-binding site [chemical binding]; other site
331272011482	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
331272011483	Phosphotransferase enzyme family; Region: APH; pfam01636
331272011484	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
331272011485	active site
331272011486	ATP binding site [chemical binding]; other site
331272011487	substrate binding site [chemical binding]; other site
331272011488	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331272011489	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272011490	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
331272011491	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272011492	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
331272011493	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
331272011494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011495	active site
331272011496	phosphorylation site [posttranslational modification]
331272011497	intermolecular recognition site; other site
331272011498	dimerization interface [polypeptide binding]; other site
331272011499	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272011500	DNA binding site [nucleotide binding]
331272011501	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
331272011502	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272011503	dimerization interface [polypeptide binding]; other site
331272011504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272011505	dimer interface [polypeptide binding]; other site
331272011506	phosphorylation site [posttranslational modification]
331272011507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272011508	ATP binding site [chemical binding]; other site
331272011509	Mg2+ binding site [ion binding]; other site
331272011510	G-X-G motif; other site
331272011511	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272011512	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272011513	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272011514	trimer interface [polypeptide binding]; other site
331272011515	eyelet of channel; other site
331272011516	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272011517	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
331272011518	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
331272011519	homodimer interface [polypeptide binding]; other site
331272011520	substrate-cofactor binding pocket; other site
331272011521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272011522	catalytic residue [active]
331272011523	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
331272011524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272011525	S-adenosylmethionine binding site [chemical binding]; other site
331272011526	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
331272011527	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
331272011528	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
331272011529	hypothetical protein; Reviewed; Region: PRK09588
331272011530	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
331272011531	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
331272011532	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
331272011533	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
331272011534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272011535	Walker A motif; other site
331272011536	ATP binding site [chemical binding]; other site
331272011537	Walker B motif; other site
331272011538	arginine finger; other site
331272011539	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
331272011540	SnoaL-like domain; Region: SnoaL_4; pfam13577
331272011541	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272011542	MarR family; Region: MarR_2; pfam12802
331272011543	cysteine desulfurase; Provisional; Region: PRK14012
331272011544	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
331272011545	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272011546	catalytic residue [active]
331272011547	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
331272011548	4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794
331272011549	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
331272011550	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
331272011551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272011552	S-adenosylmethionine binding site [chemical binding]; other site
331272011553	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272011554	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272011555	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272011556	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272011557	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011560	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272011561	putative effector binding pocket; other site
331272011562	putative dimerization interface [polypeptide binding]; other site
331272011563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011564	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
331272011565	putative effector binding pocket; other site
331272011566	putative dimerization interface [polypeptide binding]; other site
331272011567	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
331272011568	tartrate dehydrogenase; Region: TTC; TIGR02089
331272011569	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272011570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011571	putative substrate translocation pore; other site
331272011572	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
331272011573	active site
331272011574	argininosuccinate synthase; Validated; Region: PRK05370
331272011575	argininosuccinate synthase; Provisional; Region: PRK13820
331272011576	Predicted membrane protein [Function unknown]; Region: COG1289
331272011577	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272011578	Cache domain; Region: Cache_1; pfam02743
331272011579	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272011580	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272011581	metal binding site [ion binding]; metal-binding site
331272011582	active site
331272011583	I-site; other site
331272011584	lysine transporter; Provisional; Region: PRK10836
331272011585	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
331272011586	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272011587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011588	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
331272011589	dimerizarion interface [polypeptide binding]; other site
331272011590	CrgA pocket; other site
331272011591	substrate binding pocket [chemical binding]; other site
331272011592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272011593	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272011594	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272011595	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
331272011596	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
331272011597	homodimer interface [polypeptide binding]; other site
331272011598	active site
331272011599	TDP-binding site; other site
331272011600	acceptor substrate-binding pocket; other site
331272011601	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
331272011602	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272011603	DNA-binding site [nucleotide binding]; DNA binding site
331272011604	UTRA domain; Region: UTRA; pfam07702
331272011605	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272011606	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272011607	trimer interface [polypeptide binding]; other site
331272011608	eyelet of channel; other site
331272011609	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272011610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272011611	dimer interface [polypeptide binding]; other site
331272011612	conserved gate region; other site
331272011613	putative PBP binding loops; other site
331272011614	ABC-ATPase subunit interface; other site
331272011615	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272011616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272011617	dimer interface [polypeptide binding]; other site
331272011618	conserved gate region; other site
331272011619	putative PBP binding loops; other site
331272011620	ABC-ATPase subunit interface; other site
331272011621	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
331272011622	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272011623	Walker A/P-loop; other site
331272011624	ATP binding site [chemical binding]; other site
331272011625	Q-loop/lid; other site
331272011626	ABC transporter signature motif; other site
331272011627	Walker B; other site
331272011628	D-loop; other site
331272011629	H-loop/switch region; other site
331272011630	Cupin domain; Region: Cupin_2; cl17218
331272011631	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
331272011632	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
331272011633	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
331272011634	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
331272011635	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272011636	putative C-terminal domain interface [polypeptide binding]; other site
331272011637	putative GSH binding site (G-site) [chemical binding]; other site
331272011638	putative dimer interface [polypeptide binding]; other site
331272011639	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
331272011640	putative N-terminal domain interface [polypeptide binding]; other site
331272011641	putative dimer interface [polypeptide binding]; other site
331272011642	putative substrate binding pocket (H-site) [chemical binding]; other site
331272011643	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272011644	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272011645	ligand binding site [chemical binding]; other site
331272011646	flexible hinge region; other site
331272011647	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
331272011648	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
331272011649	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
331272011650	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272011651	ligand binding site [chemical binding]; other site
331272011652	Cache domain; Region: Cache_1; pfam02743
331272011653	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272011654	dimerization interface [polypeptide binding]; other site
331272011655	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272011656	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272011657	dimer interface [polypeptide binding]; other site
331272011658	putative CheW interface [polypeptide binding]; other site
331272011659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272011660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011661	active site
331272011662	phosphorylation site [posttranslational modification]
331272011663	intermolecular recognition site; other site
331272011664	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
331272011665	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272011666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011667	active site
331272011668	phosphorylation site [posttranslational modification]
331272011669	intermolecular recognition site; other site
331272011670	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272011671	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
331272011672	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
331272011673	active site
331272011674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011675	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272011676	putative substrate translocation pore; other site
331272011677	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272011678	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011679	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272011680	dimerization interface [polypeptide binding]; other site
331272011681	substrate binding pocket [chemical binding]; other site
331272011682	TIGR02594 family protein; Region: TIGR02594
331272011683	glutathione S-transferase; Provisional; Region: PRK15113
331272011684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272011685	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272011686	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272011687	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272011688	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272011689	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
331272011690	PAAR motif; Region: PAAR_motif; pfam05488
331272011691	Transposase, Mutator family; Region: Transposase_mut; pfam00872
331272011692	MULE transposase domain; Region: MULE; pfam10551
331272011693	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272011694	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272011695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011696	putative substrate translocation pore; other site
331272011697	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
331272011698	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272011699	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272011700	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272011701	MarR family; Region: MarR_2; pfam12802
331272011702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011704	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272011705	putative effector binding pocket; other site
331272011706	dimerization interface [polypeptide binding]; other site
331272011707	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272011708	MarR family; Region: MarR_2; pfam12802
331272011709	Protein of unknown function (DUF521); Region: DUF521; pfam04412
331272011710	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
331272011711	substrate binding site [chemical binding]; other site
331272011712	ligand binding site [chemical binding]; other site
331272011713	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
331272011714	substrate binding site [chemical binding]; other site
331272011715	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272011716	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272011717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011718	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272011719	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
331272011720	active site
331272011721	FMN binding site [chemical binding]; other site
331272011722	2,4-decadienoyl-CoA binding site; other site
331272011723	catalytic residue [active]
331272011724	4Fe-4S cluster binding site [ion binding]; other site
331272011725	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272011726	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
331272011727	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011729	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
331272011730	putative substrate binding pocket [chemical binding]; other site
331272011731	putative dimerization interface [polypeptide binding]; other site
331272011732	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
331272011733	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272011734	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
331272011735	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
331272011736	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
331272011737	dimer interface [polypeptide binding]; other site
331272011738	active site
331272011739	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
331272011740	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
331272011741	octamer interface [polypeptide binding]; other site
331272011742	active site
331272011743	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272011744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011745	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
331272011746	dimerizarion interface [polypeptide binding]; other site
331272011747	CrgA pocket; other site
331272011748	substrate binding pocket [chemical binding]; other site
331272011749	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272011750	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
331272011751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272011752	dimerization interface [polypeptide binding]; other site
331272011753	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272011754	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272011755	dimer interface [polypeptide binding]; other site
331272011756	putative CheW interface [polypeptide binding]; other site
331272011757	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272011758	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011759	Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545
331272011760	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
331272011761	putative alpha subunit interface [polypeptide binding]; other site
331272011762	putative active site [active]
331272011763	putative substrate binding site [chemical binding]; other site
331272011764	Fe binding site [ion binding]; other site
331272011765	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
331272011766	inter-subunit interface; other site
331272011767	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
331272011768	[2Fe-2S] cluster binding site [ion binding]; other site
331272011769	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
331272011770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272011771	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272011772	Protein of unknown function (DUF445); Region: DUF445; pfam04286
331272011773	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
331272011774	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
331272011775	acetolactate synthase; Reviewed; Region: PRK08322
331272011776	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272011777	PYR/PP interface [polypeptide binding]; other site
331272011778	dimer interface [polypeptide binding]; other site
331272011779	TPP binding site [chemical binding]; other site
331272011780	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272011781	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
331272011782	TPP-binding site [chemical binding]; other site
331272011783	dimer interface [polypeptide binding]; other site
331272011784	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
331272011785	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272011786	NAD(P) binding site [chemical binding]; other site
331272011787	catalytic residues [active]
331272011788	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
331272011789	Response regulator receiver domain; Region: Response_reg; pfam00072
331272011790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011791	active site
331272011792	phosphorylation site [posttranslational modification]
331272011793	intermolecular recognition site; other site
331272011794	dimerization interface [polypeptide binding]; other site
331272011795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
331272011796	dimer interface [polypeptide binding]; other site
331272011797	phosphorylation site [posttranslational modification]
331272011798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272011799	Mg2+ binding site [ion binding]; other site
331272011800	G-X-G motif; other site
331272011801	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272011802	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
331272011803	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272011804	dimerization interface [polypeptide binding]; other site
331272011805	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272011806	dimer interface [polypeptide binding]; other site
331272011807	putative CheW interface [polypeptide binding]; other site
331272011808	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
331272011809	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
331272011810	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
331272011811	Tetratricopeptide repeat; Region: TPR_16; pfam13432
331272011812	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
331272011813	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
331272011814	putative binding surface; other site
331272011815	active site
331272011816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272011817	ATP binding site [chemical binding]; other site
331272011818	Mg2+ binding site [ion binding]; other site
331272011819	G-X-G motif; other site
331272011820	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
331272011821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011822	Response regulator receiver domain; Region: Response_reg; pfam00072
331272011823	active site
331272011824	phosphorylation site [posttranslational modification]
331272011825	intermolecular recognition site; other site
331272011826	dimerization interface [polypeptide binding]; other site
331272011827	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
331272011828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272011829	active site
331272011830	phosphorylation site [posttranslational modification]
331272011831	intermolecular recognition site; other site
331272011832	dimerization interface [polypeptide binding]; other site
331272011833	CheB methylesterase; Region: CheB_methylest; pfam01339
331272011834	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
331272011835	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
331272011836	putative Cl- selectivity filter; other site
331272011837	putative pore gating glutamate residue; other site
331272011838	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
331272011839	Lumazine binding domain; Region: Lum_binding; pfam00677
331272011840	Lumazine binding domain; Region: Lum_binding; pfam00677
331272011841	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272011842	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272011843	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331272011844	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272011845	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
331272011846	Walker A/P-loop; other site
331272011847	ATP binding site [chemical binding]; other site
331272011848	Q-loop/lid; other site
331272011849	ABC transporter signature motif; other site
331272011850	Walker B; other site
331272011851	D-loop; other site
331272011852	H-loop/switch region; other site
331272011853	Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413
331272011854	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
331272011855	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272011856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272011857	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
331272011858	substrate binding pocket [chemical binding]; other site
331272011859	dimerization interface [polypeptide binding]; other site
331272011860	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272011861	manganese transport protein MntH; Reviewed; Region: PRK00701
331272011862	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
331272011863	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
331272011864	active site
331272011865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272011866	short chain dehydrogenase; Validated; Region: PRK07069
331272011867	NAD(P) binding site [chemical binding]; other site
331272011868	active site
331272011869	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
331272011870	Prostaglandin dehydrogenases; Region: PGDH; cd05288
331272011871	NAD(P) binding site [chemical binding]; other site
331272011872	substrate binding site [chemical binding]; other site
331272011873	dimer interface [polypeptide binding]; other site
331272011874	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
331272011875	Domain of unknown function DUF20; Region: UPF0118; pfam01594
331272011876	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
331272011877	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
331272011878	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
331272011879	generic binding surface I; other site
331272011880	generic binding surface II; other site
331272011881	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
331272011882	putative active site [active]
331272011883	putative catalytic site [active]
331272011884	putative Mg binding site IVb [ion binding]; other site
331272011885	putative DNA binding site [nucleotide binding]; other site
331272011886	putative phosphate binding site [ion binding]; other site
331272011887	putative Mg binding site IVa [ion binding]; other site
331272011888	YCII-related domain; Region: YCII; cl00999
331272011889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
331272011890	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272011891	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
331272011892	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
331272011893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272011894	Rubrerythrin [Energy production and conversion]; Region: COG1592
331272011895	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
331272011896	binuclear metal center [ion binding]; other site
331272011897	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
331272011898	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
331272011899	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
331272011900	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
331272011901	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
331272011902	Substrate binding site; other site
331272011903	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
331272011904	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
331272011905	Bacterial sugar transferase; Region: Bac_transf; pfam02397
331272011906	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
331272011907	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
331272011908	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
331272011909	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
331272011910	Low molecular weight phosphatase family; Region: LMWPc; cd00115
331272011911	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
331272011912	active site
331272011913	polysaccharide export protein Wza; Provisional; Region: PRK15078
331272011914	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
331272011915	SLBB domain; Region: SLBB; pfam10531
331272011916	SLBB domain; Region: SLBB; pfam10531
331272011917	tyrosine kinase; Provisional; Region: PRK11519
331272011918	Chain length determinant protein; Region: Wzz; pfam02706
331272011919	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
331272011920	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272011921	P-loop; other site
331272011922	Magnesium ion binding site [ion binding]; other site
331272011923	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272011924	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272011925	active site
331272011926	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272011927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272011928	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272011929	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
331272011930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272011931	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272011932	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272011933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011934	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272011935	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272011936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011937	putative substrate translocation pore; other site
331272011938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272011939	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272011940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272011941	Coenzyme A binding pocket [chemical binding]; other site
331272011942	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011943	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272011944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272011945	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
331272011946	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
331272011947	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
331272011948	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
331272011949	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
331272011950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272011951	Walker A motif; other site
331272011952	ATP binding site [chemical binding]; other site
331272011953	Walker B motif; other site
331272011954	arginine finger; other site
331272011955	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272011956	Predicted membrane protein [Function unknown]; Region: COG2246
331272011957	GtrA-like protein; Region: GtrA; pfam04138
331272011958	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272011959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272011960	substrate binding pocket [chemical binding]; other site
331272011961	membrane-bound complex binding site; other site
331272011962	hinge residues; other site
331272011963	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
331272011964	RES domain; Region: RES; smart00953
331272011965	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331272011966	active site
331272011967	metal binding site [ion binding]; metal-binding site
331272011968	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
331272011969	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272011970	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
331272011971	putative C-terminal domain interface [polypeptide binding]; other site
331272011972	putative GSH binding site (G-site) [chemical binding]; other site
331272011973	putative dimer interface [polypeptide binding]; other site
331272011974	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
331272011975	putative N-terminal domain interface [polypeptide binding]; other site
331272011976	putative dimer interface [polypeptide binding]; other site
331272011977	putative substrate binding pocket (H-site) [chemical binding]; other site
331272011978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272011979	S-adenosylmethionine binding site [chemical binding]; other site
331272011980	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
331272011981	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
331272011982	active site
331272011983	catalytic site [active]
331272011984	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
331272011985	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
331272011986	active site
331272011987	thiamine phosphate binding site [chemical binding]; other site
331272011988	pyrophosphate binding site [ion binding]; other site
331272011989	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
331272011990	Domain of unknown function DUF21; Region: DUF21; pfam01595
331272011991	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
331272011992	Transporter associated domain; Region: CorC_HlyC; smart01091
331272011993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272011994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272011995	dimer interface [polypeptide binding]; other site
331272011996	phosphorylation site [posttranslational modification]
331272011997	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
331272011998	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272011999	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012001	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272012002	dimerization interface [polypeptide binding]; other site
331272012003	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
331272012004	active site 1 [active]
331272012005	dimer interface [polypeptide binding]; other site
331272012006	hexamer interface [polypeptide binding]; other site
331272012007	active site 2 [active]
331272012008	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
331272012009	active site 1 [active]
331272012010	dimer interface [polypeptide binding]; other site
331272012011	hexamer interface [polypeptide binding]; other site
331272012012	active site 2 [active]
331272012013	CHAD domain; Region: CHAD; pfam05235
331272012014	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
331272012015	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
331272012016	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
331272012017	molybdenum-pterin binding domain; Region: Mop; TIGR00638
331272012018	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
331272012019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272012020	Walker A/P-loop; other site
331272012021	ATP binding site [chemical binding]; other site
331272012022	Q-loop/lid; other site
331272012023	ABC transporter signature motif; other site
331272012024	Walker B; other site
331272012025	D-loop; other site
331272012026	H-loop/switch region; other site
331272012027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012028	dimer interface [polypeptide binding]; other site
331272012029	conserved gate region; other site
331272012030	putative PBP binding loops; other site
331272012031	ABC-ATPase subunit interface; other site
331272012032	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
331272012033	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272012034	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
331272012035	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
331272012036	active site
331272012037	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
331272012038	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
331272012039	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
331272012040	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272012041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272012042	putative Zn2+ binding site [ion binding]; other site
331272012043	putative DNA binding site [nucleotide binding]; other site
331272012044	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
331272012045	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
331272012046	putative active site [active]
331272012047	putative substrate binding site [chemical binding]; other site
331272012048	ATP binding site [chemical binding]; other site
331272012049	AMP nucleosidase; Provisional; Region: PRK08292
331272012050	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
331272012051	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
331272012052	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
331272012053	DNA polymerase I; Provisional; Region: PRK05755
331272012054	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
331272012055	active site
331272012056	metal binding site 1 [ion binding]; metal-binding site
331272012057	putative 5' ssDNA interaction site; other site
331272012058	metal binding site 3; metal-binding site
331272012059	metal binding site 2 [ion binding]; metal-binding site
331272012060	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
331272012061	putative DNA binding site [nucleotide binding]; other site
331272012062	putative metal binding site [ion binding]; other site
331272012063	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
331272012064	active site
331272012065	catalytic site [active]
331272012066	substrate binding site [chemical binding]; other site
331272012067	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
331272012068	active site
331272012069	DNA binding site [nucleotide binding]
331272012070	catalytic site [active]
331272012071	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
331272012072	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272012073	Dienelactone hydrolase family; Region: DLH; pfam01738
331272012074	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
331272012075	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
331272012076	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
331272012077	active site residue [active]
331272012078	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
331272012079	active site residue [active]
331272012080	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272012081	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272012082	[2Fe-2S] cluster binding site [ion binding]; other site
331272012083	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
331272012084	alpha subunit interface [polypeptide binding]; other site
331272012085	active site
331272012086	substrate binding site [chemical binding]; other site
331272012087	Fe binding site [ion binding]; other site
331272012088	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
331272012089	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
331272012090	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
331272012091	substrate binding pocket [chemical binding]; other site
331272012092	chain length determination region; other site
331272012093	substrate-Mg2+ binding site; other site
331272012094	catalytic residues [active]
331272012095	aspartate-rich region 1; other site
331272012096	active site lid residues [active]
331272012097	aspartate-rich region 2; other site
331272012098	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
331272012099	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
331272012100	TPP-binding site; other site
331272012101	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331272012102	PYR/PP interface [polypeptide binding]; other site
331272012103	dimer interface [polypeptide binding]; other site
331272012104	TPP binding site [chemical binding]; other site
331272012105	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272012106	putative GTP cyclohydrolase; Provisional; Region: PRK13674
331272012107	UGMP family protein; Validated; Region: PRK09604
331272012108	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
331272012109	Predicted flavoproteins [General function prediction only]; Region: COG2081
331272012110	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
331272012111	Yqey-like protein; Region: YqeY; pfam09424
331272012112	DNA primase; Validated; Region: dnaG; PRK05667
331272012113	CHC2 zinc finger; Region: zf-CHC2; pfam01807
331272012114	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
331272012115	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
331272012116	active site
331272012117	metal binding site [ion binding]; metal-binding site
331272012118	interdomain interaction site; other site
331272012119	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
331272012120	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
331272012121	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
331272012122	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
331272012123	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331272012124	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
331272012125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272012126	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
331272012127	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272012128	DNA binding residues [nucleotide binding]
331272012129	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
331272012130	PLD-like domain; Region: PLDc_2; pfam13091
331272012131	putative active site [active]
331272012132	catalytic site [active]
331272012133	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
331272012134	PLD-like domain; Region: PLDc_2; pfam13091
331272012135	putative active site [active]
331272012136	catalytic site [active]
331272012137	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272012138	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272012139	DNA-binding site [nucleotide binding]; DNA binding site
331272012140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272012141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012142	homodimer interface [polypeptide binding]; other site
331272012143	catalytic residue [active]
331272012144	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
331272012145	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
331272012146	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
331272012147	peptidase domain interface [polypeptide binding]; other site
331272012148	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
331272012149	active site
331272012150	catalytic triad [active]
331272012151	calcium binding site [ion binding]; other site
331272012152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272012153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272012154	active site
331272012155	phosphorylation site [posttranslational modification]
331272012156	intermolecular recognition site; other site
331272012157	dimerization interface [polypeptide binding]; other site
331272012158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272012159	DNA binding site [nucleotide binding]
331272012160	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272012161	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331272012162	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272012163	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272012164	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272012165	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
331272012166	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
331272012167	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
331272012168	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
331272012169	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
331272012170	tetramer interface [polypeptide binding]; other site
331272012171	heme binding pocket [chemical binding]; other site
331272012172	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
331272012173	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272012174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012175	putative substrate translocation pore; other site
331272012176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012177	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
331272012178	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272012179	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272012180	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
331272012181	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272012182	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
331272012183	putative mechanosensitive channel protein; Provisional; Region: PRK11465
331272012184	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272012185	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
331272012186	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272012187	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
331272012188	NAD-dependent deacetylase; Provisional; Region: PRK05333
331272012189	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
331272012190	NAD+ binding site [chemical binding]; other site
331272012191	substrate binding site [chemical binding]; other site
331272012192	Zn binding site [ion binding]; other site
331272012193	Methyltransferase domain; Region: Methyltransf_23; pfam13489
331272012194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272012195	S-adenosylmethionine binding site [chemical binding]; other site
331272012196	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272012197	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
331272012198	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
331272012199	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272012200	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
331272012201	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272012202	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
331272012203	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
331272012204	E3 interaction surface; other site
331272012205	lipoyl attachment site [posttranslational modification]; other site
331272012206	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
331272012207	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
331272012208	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
331272012209	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272012210	N-terminal plug; other site
331272012211	ligand-binding site [chemical binding]; other site
331272012212	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
331272012213	Lipase (class 2); Region: Lipase_2; pfam01674
331272012214	PGAP1-like protein; Region: PGAP1; pfam07819
331272012215	lipase chaperone; Provisional; Region: PRK01294
331272012216	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
331272012217	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272012218	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272012219	DNA-binding site [nucleotide binding]; DNA binding site
331272012220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272012221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012222	homodimer interface [polypeptide binding]; other site
331272012223	catalytic residue [active]
331272012224	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272012225	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
331272012226	Walker A/P-loop; other site
331272012227	ATP binding site [chemical binding]; other site
331272012228	Q-loop/lid; other site
331272012229	ABC transporter signature motif; other site
331272012230	Walker B; other site
331272012231	D-loop; other site
331272012232	H-loop/switch region; other site
331272012233	TOBE domain; Region: TOBE_2; pfam08402
331272012234	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
331272012235	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272012236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012237	dimer interface [polypeptide binding]; other site
331272012238	conserved gate region; other site
331272012239	putative PBP binding loops; other site
331272012240	ABC-ATPase subunit interface; other site
331272012241	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272012242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012243	dimer interface [polypeptide binding]; other site
331272012244	conserved gate region; other site
331272012245	putative PBP binding loops; other site
331272012246	ABC-ATPase subunit interface; other site
331272012247	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272012248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012250	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
331272012251	peptidase domain interface [polypeptide binding]; other site
331272012252	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
331272012253	active site
331272012254	catalytic triad [active]
331272012255	calcium binding site [ion binding]; other site
331272012256	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272012257	dimerization interface [polypeptide binding]; other site
331272012258	putative DNA binding site [nucleotide binding]; other site
331272012259	putative Zn2+ binding site [ion binding]; other site
331272012260	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
331272012261	putative hydrophobic ligand binding site [chemical binding]; other site
331272012262	Domain of unknown function (DU1801); Region: DUF1801; cl17490
331272012263	aconitate hydratase; Provisional; Region: acnA; PRK12881
331272012264	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
331272012265	substrate binding site [chemical binding]; other site
331272012266	ligand binding site [chemical binding]; other site
331272012267	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
331272012268	substrate binding site [chemical binding]; other site
331272012269	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
331272012270	2-methylcitrate dehydratase; Region: prpD; TIGR02330
331272012271	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
331272012272	malate dehydrogenase; Provisional; Region: PRK05442
331272012273	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
331272012274	NAD(P) binding site [chemical binding]; other site
331272012275	dimer interface [polypeptide binding]; other site
331272012276	malate binding site [chemical binding]; other site
331272012277	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
331272012278	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272012279	DNA-binding site [nucleotide binding]; DNA binding site
331272012280	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
331272012281	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
331272012282	Iron-sulfur protein interface; other site
331272012283	proximal quinone binding site [chemical binding]; other site
331272012284	SdhD (CybS) interface [polypeptide binding]; other site
331272012285	proximal heme binding site [chemical binding]; other site
331272012286	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
331272012287	SdhC subunit interface [polypeptide binding]; other site
331272012288	proximal heme binding site [chemical binding]; other site
331272012289	cardiolipin binding site; other site
331272012290	Iron-sulfur protein interface; other site
331272012291	proximal quinone binding site [chemical binding]; other site
331272012292	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
331272012293	L-aspartate oxidase; Provisional; Region: PRK06175
331272012294	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
331272012295	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
331272012296	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
331272012297	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
331272012298	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
331272012299	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
331272012300	dimer interface [polypeptide binding]; other site
331272012301	active site
331272012302	citrylCoA binding site [chemical binding]; other site
331272012303	NADH binding [chemical binding]; other site
331272012304	cationic pore residues; other site
331272012305	oxalacetate/citrate binding site [chemical binding]; other site
331272012306	coenzyme A binding site [chemical binding]; other site
331272012307	catalytic triad [active]
331272012308	Cupin domain; Region: Cupin_2; cl17218
331272012309	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272012310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272012311	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
331272012312	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272012313	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
331272012314	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
331272012315	Amidinotransferase; Region: Amidinotransf; cl12043
331272012316	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272012317	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272012318	AsnC family; Region: AsnC_trans_reg; pfam01037
331272012319	lysine transporter; Provisional; Region: PRK10836
331272012320	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
331272012321	glutathione s-transferase; Provisional; Region: PTZ00057
331272012322	GSH binding site (G-site) [chemical binding]; other site
331272012323	C-terminal domain interface [polypeptide binding]; other site
331272012324	dimer interface [polypeptide binding]; other site
331272012325	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
331272012326	dimer interface [polypeptide binding]; other site
331272012327	N-terminal domain interface [polypeptide binding]; other site
331272012328	substrate binding pocket (H-site) [chemical binding]; other site
331272012329	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272012330	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272012331	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
331272012332	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272012333	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
331272012334	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
331272012335	substrate binding site [chemical binding]; other site
331272012336	ligand binding site [chemical binding]; other site
331272012337	Entericidin EcnA/B family; Region: Entericidin; cl02322
331272012338	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
331272012339	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
331272012340	substrate binding site [chemical binding]; other site
331272012341	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
331272012342	tartrate dehydrogenase; Region: TTC; TIGR02089
331272012343	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
331272012344	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
331272012345	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
331272012346	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
331272012347	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
331272012348	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
331272012349	FimV N-terminal domain; Region: FimV_core; TIGR03505
331272012350	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
331272012351	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
331272012352	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
331272012353	dimerization interface 3.5A [polypeptide binding]; other site
331272012354	active site
331272012355	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
331272012356	active site
331272012357	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
331272012358	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
331272012359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012360	catalytic residue [active]
331272012361	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
331272012362	DNA methylase; Region: N6_N4_Mtase; pfam01555
331272012363	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
331272012364	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
331272012365	substrate binding site [chemical binding]; other site
331272012366	active site
331272012367	catalytic residues [active]
331272012368	heterodimer interface [polypeptide binding]; other site
331272012369	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
331272012370	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
331272012371	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
331272012372	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
331272012373	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
331272012374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
331272012375	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
331272012376	Colicin V production protein; Region: Colicin_V; pfam02674
331272012377	amidophosphoribosyltransferase; Provisional; Region: PRK09246
331272012378	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
331272012379	active site
331272012380	tetramer interface [polypeptide binding]; other site
331272012381	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
331272012382	active site
331272012383	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
331272012384	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
331272012385	homodimer interface [polypeptide binding]; other site
331272012386	substrate-cofactor binding pocket; other site
331272012387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012388	catalytic residue [active]
331272012389	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
331272012390	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
331272012391	putative active site [active]
331272012392	putative NTP binding site [chemical binding]; other site
331272012393	putative nucleic acid binding site [nucleotide binding]; other site
331272012394	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
331272012395	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272012396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272012397	NAD(P) binding site [chemical binding]; other site
331272012398	active site
331272012399	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
331272012400	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
331272012401	NADP-binding site; other site
331272012402	homotetramer interface [polypeptide binding]; other site
331272012403	substrate binding site [chemical binding]; other site
331272012404	homodimer interface [polypeptide binding]; other site
331272012405	active site
331272012406	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272012407	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
331272012408	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
331272012409	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272012410	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
331272012411	putative ADP-binding pocket [chemical binding]; other site
331272012412	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272012413	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272012414	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272012415	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
331272012416	active site
331272012417	tetramer interface; other site
331272012418	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272012419	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
331272012420	dimer interface [polypeptide binding]; other site
331272012421	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272012422	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272012423	trimer interface [polypeptide binding]; other site
331272012424	eyelet of channel; other site
331272012425	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
331272012426	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
331272012427	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
331272012428	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
331272012429	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
331272012430	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
331272012431	molybdopterin cofactor binding site; other site
331272012432	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
331272012433	4Fe-4S binding domain; Region: Fer4; cl02805
331272012434	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
331272012435	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
331272012436	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
331272012437	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
331272012438	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
331272012439	selenocysteine synthase; Provisional; Region: PRK04311
331272012440	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
331272012441	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
331272012442	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272012443	catalytic residue [active]
331272012444	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
331272012445	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
331272012446	G1 box; other site
331272012447	putative GEF interaction site [polypeptide binding]; other site
331272012448	GTP/Mg2+ binding site [chemical binding]; other site
331272012449	Switch I region; other site
331272012450	G2 box; other site
331272012451	G3 box; other site
331272012452	Switch II region; other site
331272012453	G4 box; other site
331272012454	G5 box; other site
331272012455	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
331272012456	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
331272012457	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
331272012458	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
331272012459	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272012460	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
331272012461	NADP binding site [chemical binding]; other site
331272012462	putative substrate binding site [chemical binding]; other site
331272012463	active site
331272012464	Cupin; Region: Cupin_6; pfam12852
331272012465	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272012466	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272012467	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272012468	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272012469	DNA binding residues [nucleotide binding]
331272012470	dimerization interface [polypeptide binding]; other site
331272012471	Predicted amidohydrolase [General function prediction only]; Region: COG0388
331272012472	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
331272012473	putative active site [active]
331272012474	catalytic triad [active]
331272012475	putative dimer interface [polypeptide binding]; other site
331272012476	amino acid transporter; Region: 2A0306; TIGR00909
331272012477	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272012478	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272012479	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272012480	short chain dehydrogenase; Provisional; Region: PRK06523
331272012481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272012482	NAD(P) binding site [chemical binding]; other site
331272012483	active site
331272012484	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
331272012485	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
331272012486	nudix motif; other site
331272012487	xanthine permease; Region: pbuX; TIGR03173
331272012488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012490	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
331272012491	putative substrate binding pocket [chemical binding]; other site
331272012492	putative dimerization interface [polypeptide binding]; other site
331272012493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272012494	C factor cell-cell signaling protein; Provisional; Region: PRK09009
331272012495	NAD(P) binding site [chemical binding]; other site
331272012496	active site
331272012497	Uncharacterized conserved protein [Function unknown]; Region: COG1359
331272012498	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
331272012499	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
331272012500	putative active site [active]
331272012501	metal binding site [ion binding]; metal-binding site
331272012502	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272012503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012504	putative substrate translocation pore; other site
331272012505	ornithine decarboxylase; Provisional; Region: PRK13578
331272012506	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
331272012507	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
331272012508	homodimer interface [polypeptide binding]; other site
331272012509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012510	catalytic residue [active]
331272012511	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
331272012512	arginine decarboxylase; Provisional; Region: PRK15029
331272012513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272012514	active site
331272012515	phosphorylation site [posttranslational modification]
331272012516	intermolecular recognition site; other site
331272012517	dimerization interface [polypeptide binding]; other site
331272012518	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
331272012519	homodimer interface [polypeptide binding]; other site
331272012520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012521	catalytic residue [active]
331272012522	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
331272012523	putrescine transporter; Provisional; Region: potE; PRK10655
331272012524	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012526	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272012527	putative effector binding pocket; other site
331272012528	dimerization interface [polypeptide binding]; other site
331272012529	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
331272012530	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272012531	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272012532	substrate binding pocket [chemical binding]; other site
331272012533	membrane-bound complex binding site; other site
331272012534	hinge residues; other site
331272012535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
331272012536	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
331272012537	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
331272012538	peptide binding site [polypeptide binding]; other site
331272012539	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
331272012540	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272012541	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
331272012542	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272012543	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272012544	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272012545	Walker A/P-loop; other site
331272012546	ATP binding site [chemical binding]; other site
331272012547	Q-loop/lid; other site
331272012548	ABC transporter signature motif; other site
331272012549	Walker B; other site
331272012550	D-loop; other site
331272012551	H-loop/switch region; other site
331272012552	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272012553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012554	dimer interface [polypeptide binding]; other site
331272012555	putative PBP binding loops; other site
331272012556	ABC-ATPase subunit interface; other site
331272012557	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272012558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012559	dimer interface [polypeptide binding]; other site
331272012560	conserved gate region; other site
331272012561	ABC-ATPase subunit interface; other site
331272012562	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272012563	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272012564	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
331272012565	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
331272012566	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
331272012567	Ligand binding site; other site
331272012568	Putative Catalytic site; other site
331272012569	DXD motif; other site
331272012570	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
331272012571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272012572	substrate binding pocket [chemical binding]; other site
331272012573	membrane-bound complex binding site; other site
331272012574	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
331272012575	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012577	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272012578	dimerization interface [polypeptide binding]; other site
331272012579	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
331272012580	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
331272012581	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
331272012582	Na binding site [ion binding]; other site
331272012583	putative substrate binding site [chemical binding]; other site
331272012584	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
331272012585	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
331272012586	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272012587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012588	putative substrate translocation pore; other site
331272012589	MarR family; Region: MarR_2; cl17246
331272012590	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272012591	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272012592	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272012593	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272012594	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272012595	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272012596	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
331272012597	Isochorismatase family; Region: Isochorismatase; pfam00857
331272012598	catalytic triad [active]
331272012599	conserved cis-peptide bond; other site
331272012600	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272012601	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
331272012602	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272012603	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
331272012604	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272012605	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272012606	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
331272012607	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272012608	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272012609	Cytochrome c; Region: Cytochrom_C; pfam00034
331272012610	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272012611	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
331272012612	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
331272012613	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
331272012614	tetrameric interface [polypeptide binding]; other site
331272012615	NAD binding site [chemical binding]; other site
331272012616	catalytic residues [active]
331272012617	shikimate transporter; Provisional; Region: PRK09952
331272012618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012619	putative substrate translocation pore; other site
331272012620	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012622	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272012623	dimerization interface [polypeptide binding]; other site
331272012624	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
331272012625	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272012626	motif II; other site
331272012627	Isochorismatase family; Region: Isochorismatase; pfam00857
331272012628	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
331272012629	catalytic triad [active]
331272012630	dimer interface [polypeptide binding]; other site
331272012631	conserved cis-peptide bond; other site
331272012632	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272012633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012634	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
331272012635	putative effector binding pocket; other site
331272012636	putative dimerization interface [polypeptide binding]; other site
331272012637	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
331272012638	GAF domain; Region: GAF; pfam01590
331272012639	PAS fold; Region: PAS; pfam00989
331272012640	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
331272012641	putative active site [active]
331272012642	heme pocket [chemical binding]; other site
331272012643	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272012644	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272012645	metal binding site [ion binding]; metal-binding site
331272012646	active site
331272012647	I-site; other site
331272012648	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272012649	Response regulator receiver domain; Region: Response_reg; pfam00072
331272012650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272012651	active site
331272012652	phosphorylation site [posttranslational modification]
331272012653	intermolecular recognition site; other site
331272012654	dimerization interface [polypeptide binding]; other site
331272012655	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272012656	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272012657	metal binding site [ion binding]; metal-binding site
331272012658	active site
331272012659	I-site; other site
331272012660	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
331272012661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272012662	active site
331272012663	phosphorylation site [posttranslational modification]
331272012664	intermolecular recognition site; other site
331272012665	CheB methylesterase; Region: CheB_methylest; pfam01339
331272012666	Protein of unknown function (DUF969); Region: DUF969; pfam06149
331272012667	Predicted membrane protein [Function unknown]; Region: COG3817
331272012668	Protein of unknown function (DUF979); Region: DUF979; pfam06166
331272012669	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
331272012670	L-asparaginase II; Region: Asparaginase_II; pfam06089
331272012671	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012673	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272012674	putative effector binding pocket; other site
331272012675	dimerization interface [polypeptide binding]; other site
331272012676	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
331272012677	Aspartase; Region: Aspartase; cd01357
331272012678	active sites [active]
331272012679	tetramer interface [polypeptide binding]; other site
331272012680	L-asparagine permease; Provisional; Region: PRK15049
331272012681	putative hydrolase; Provisional; Region: PRK11460
331272012682	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272012683	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272012684	dimerization interface [polypeptide binding]; other site
331272012685	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
331272012686	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
331272012687	putative binding surface; other site
331272012688	active site
331272012689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272012690	ATP binding site [chemical binding]; other site
331272012691	Mg2+ binding site [ion binding]; other site
331272012692	G-X-G motif; other site
331272012693	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272012694	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
331272012695	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
331272012696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272012697	active site
331272012698	phosphorylation site [posttranslational modification]
331272012699	intermolecular recognition site; other site
331272012700	dimerization interface [polypeptide binding]; other site
331272012701	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
331272012702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272012703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012704	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272012705	dimerization interface [polypeptide binding]; other site
331272012706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012707	putative substrate translocation pore; other site
331272012708	enoyl-CoA hydratase; Validated; Region: PRK08139
331272012709	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272012710	substrate binding site [chemical binding]; other site
331272012711	oxyanion hole (OAH) forming residues; other site
331272012712	trimer interface [polypeptide binding]; other site
331272012713	alanine racemase; Reviewed; Region: PRK13340
331272012714	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
331272012715	active site
331272012716	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272012717	substrate binding site [chemical binding]; other site
331272012718	catalytic residues [active]
331272012719	dimer interface [polypeptide binding]; other site
331272012720	MAPEG family; Region: MAPEG; cl09190
331272012721	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272012722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272012724	dimerization interface [polypeptide binding]; other site
331272012725	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331272012726	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272012727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272012728	Walker A/P-loop; other site
331272012729	ATP binding site [chemical binding]; other site
331272012730	Q-loop/lid; other site
331272012731	ABC transporter signature motif; other site
331272012732	Walker B; other site
331272012733	D-loop; other site
331272012734	H-loop/switch region; other site
331272012735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272012736	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
331272012737	Walker A/P-loop; other site
331272012738	ATP binding site [chemical binding]; other site
331272012739	Q-loop/lid; other site
331272012740	ABC transporter signature motif; other site
331272012741	Walker B; other site
331272012742	D-loop; other site
331272012743	H-loop/switch region; other site
331272012744	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272012745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272012746	substrate binding pocket [chemical binding]; other site
331272012747	membrane-bound complex binding site; other site
331272012748	hinge residues; other site
331272012749	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272012750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012751	dimer interface [polypeptide binding]; other site
331272012752	conserved gate region; other site
331272012753	putative PBP binding loops; other site
331272012754	ABC-ATPase subunit interface; other site
331272012755	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
331272012756	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272012757	Walker A/P-loop; other site
331272012758	ATP binding site [chemical binding]; other site
331272012759	Q-loop/lid; other site
331272012760	ABC transporter signature motif; other site
331272012761	Walker B; other site
331272012762	D-loop; other site
331272012763	H-loop/switch region; other site
331272012764	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
331272012765	hypothetical protein; Provisional; Region: PRK07483
331272012766	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272012767	inhibitor-cofactor binding pocket; inhibition site
331272012768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272012769	catalytic residue [active]
331272012770	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272012771	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
331272012772	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
331272012773	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
331272012774	catalytic residue [active]
331272012775	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
331272012776	catalytic residues [active]
331272012777	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272012778	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272012779	peroxiredoxin; Region: AhpC; TIGR03137
331272012780	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
331272012781	dimer interface [polypeptide binding]; other site
331272012782	decamer (pentamer of dimers) interface [polypeptide binding]; other site
331272012783	catalytic triad [active]
331272012784	peroxidatic and resolving cysteines [active]
331272012785	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
331272012786	oligomeric interface; other site
331272012787	putative active site [active]
331272012788	homodimer interface [polypeptide binding]; other site
331272012789	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272012790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012791	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272012792	dimerization interface [polypeptide binding]; other site
331272012793	substrate binding pocket [chemical binding]; other site
331272012794	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272012795	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272012796	dimerization interface [polypeptide binding]; other site
331272012797	ligand binding site [chemical binding]; other site
331272012798	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
331272012799	allantoate amidohydrolase; Reviewed; Region: PRK12891
331272012800	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
331272012801	active site
331272012802	metal binding site [ion binding]; metal-binding site
331272012803	dimer interface [polypeptide binding]; other site
331272012804	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272012805	Cytochrome c; Region: Cytochrom_C; pfam00034
331272012806	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
331272012807	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
331272012808	glutaminase active site [active]
331272012809	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
331272012810	dimer interface [polypeptide binding]; other site
331272012811	active site
331272012812	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
331272012813	dimer interface [polypeptide binding]; other site
331272012814	active site
331272012815	N-glycosyltransferase; Provisional; Region: PRK11204
331272012816	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
331272012817	DXD motif; other site
331272012818	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
331272012819	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
331272012820	putative active site [active]
331272012821	putative metal binding site [ion binding]; other site
331272012822	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
331272012823	cell density-dependent motility repressor; Provisional; Region: PRK10082
331272012824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012825	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272012826	dimerization interface [polypeptide binding]; other site
331272012827	Uncharacterized conserved protein [Function unknown]; Region: COG2308
331272012828	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
331272012829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
331272012830	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
331272012831	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
331272012832	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
331272012833	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
331272012834	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
331272012835	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
331272012836	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
331272012837	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
331272012838	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
331272012839	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
331272012840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
331272012841	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
331272012842	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
331272012843	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
331272012844	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
331272012845	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
331272012846	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
331272012847	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272012848	Patatin-like phospholipase; Region: Patatin; pfam01734
331272012849	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272012850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272012851	catalytic residue [active]
331272012852	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272012853	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
331272012854	PYR/PP interface [polypeptide binding]; other site
331272012855	dimer interface [polypeptide binding]; other site
331272012856	TPP binding site [chemical binding]; other site
331272012857	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
331272012858	TPP-binding site [chemical binding]; other site
331272012859	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
331272012860	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272012861	tetramer interface [polypeptide binding]; other site
331272012862	active site
331272012863	Mg2+/Mn2+ binding site [ion binding]; other site
331272012864	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
331272012865	active site
331272012866	metal-binding site
331272012867	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
331272012868	active site
331272012869	metal-binding site
331272012870	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
331272012871	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
331272012872	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
331272012873	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
331272012874	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
331272012875	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
331272012876	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272012877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012878	putative substrate translocation pore; other site
331272012879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012880	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272012881	MarR family; Region: MarR_2; pfam12802
331272012882	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
331272012883	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
331272012884	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
331272012885	DNA binding residues [nucleotide binding]
331272012886	putative dimer interface [polypeptide binding]; other site
331272012887	putative metal binding residues [ion binding]; other site
331272012888	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
331272012889	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
331272012890	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331272012891	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
331272012892	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272012893	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
331272012894	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
331272012895	DNA binding residues [nucleotide binding]
331272012896	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
331272012897	Bacterial SH3 domain; Region: SH3_3; pfam08239
331272012898	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
331272012899	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
331272012900	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
331272012901	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
331272012902	dimer interface [polypeptide binding]; other site
331272012903	NADP binding site [chemical binding]; other site
331272012904	catalytic residues [active]
331272012905	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331272012906	Spore germination protein; Region: Spore_permease; cl17796
331272012907	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272012908	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272012909	inhibitor site; inhibition site
331272012910	active site
331272012911	dimer interface [polypeptide binding]; other site
331272012912	catalytic residue [active]
331272012913	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
331272012914	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
331272012915	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272012916	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272012917	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272012918	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
331272012919	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
331272012920	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272012921	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
331272012922	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272012923	dimerization interface [polypeptide binding]; other site
331272012924	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
331272012925	Cupin domain; Region: Cupin_2; pfam07883
331272012926	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272012927	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272012928	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
331272012929	maleylacetoacetate isomerase; Region: maiA; TIGR01262
331272012930	C-terminal domain interface [polypeptide binding]; other site
331272012931	GSH binding site (G-site) [chemical binding]; other site
331272012932	putative dimer interface [polypeptide binding]; other site
331272012933	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
331272012934	dimer interface [polypeptide binding]; other site
331272012935	N-terminal domain interface [polypeptide binding]; other site
331272012936	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
331272012937	salicylate hydroxylase; Provisional; Region: PRK08163
331272012938	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272012939	benzoate transport; Region: 2A0115; TIGR00895
331272012940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012941	putative substrate translocation pore; other site
331272012942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012943	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272012944	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
331272012945	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331272012946	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272012947	active site
331272012948	metal binding site [ion binding]; metal-binding site
331272012949	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272012950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272012951	S-adenosylmethionine binding site [chemical binding]; other site
331272012952	BCCT family transporter; Region: BCCT; pfam02028
331272012953	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272012954	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272012955	trimer interface [polypeptide binding]; other site
331272012956	eyelet of channel; other site
331272012957	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
331272012958	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
331272012959	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
331272012960	putative active site [active]
331272012961	putative catalytic site [active]
331272012962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272012963	D-galactonate transporter; Region: 2A0114; TIGR00893
331272012964	putative substrate translocation pore; other site
331272012965	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272012966	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272012967	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272012968	putative active site [active]
331272012969	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
331272012970	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
331272012971	catalytic nucleophile [active]
331272012972	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
331272012973	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272012974	Walker A/P-loop; other site
331272012975	ATP binding site [chemical binding]; other site
331272012976	Q-loop/lid; other site
331272012977	ABC transporter signature motif; other site
331272012978	Walker B; other site
331272012979	D-loop; other site
331272012980	H-loop/switch region; other site
331272012981	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272012982	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272012983	Walker A/P-loop; other site
331272012984	ATP binding site [chemical binding]; other site
331272012985	Q-loop/lid; other site
331272012986	ABC transporter signature motif; other site
331272012987	Walker B; other site
331272012988	D-loop; other site
331272012989	H-loop/switch region; other site
331272012990	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
331272012991	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
331272012992	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
331272012993	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
331272012994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272012995	dimer interface [polypeptide binding]; other site
331272012996	conserved gate region; other site
331272012997	putative PBP binding loops; other site
331272012998	ABC-ATPase subunit interface; other site
331272012999	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
331272013000	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
331272013001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013002	dimer interface [polypeptide binding]; other site
331272013003	conserved gate region; other site
331272013004	putative PBP binding loops; other site
331272013005	ABC-ATPase subunit interface; other site
331272013006	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
331272013007	homodimer interface [polypeptide binding]; other site
331272013008	homotetramer interface [polypeptide binding]; other site
331272013009	active site pocket [active]
331272013010	cleavage site
331272013011	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
331272013012	SxDxEG motif; other site
331272013013	active site
331272013014	metal binding site [ion binding]; metal-binding site
331272013015	homopentamer interface [polypeptide binding]; other site
331272013016	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272013017	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272013018	catalytic site [active]
331272013019	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272013020	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
331272013021	heterodimer interface [polypeptide binding]; other site
331272013022	active site
331272013023	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
331272013024	heterodimer interface [polypeptide binding]; other site
331272013025	multimer interface [polypeptide binding]; other site
331272013026	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
331272013027	active site
331272013028	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
331272013029	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272013030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272013031	non-specific DNA binding site [nucleotide binding]; other site
331272013032	salt bridge; other site
331272013033	sequence-specific DNA binding site [nucleotide binding]; other site
331272013034	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
331272013035	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013036	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272013037	dimerization interface [polypeptide binding]; other site
331272013038	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
331272013039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
331272013040	putative transporter; Provisional; Region: PRK11021
331272013041	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
331272013042	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
331272013043	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
331272013044	haloalkane dehalogenase; Provisional; Region: PRK00870
331272013045	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272013046	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272013047	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331272013048	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
331272013049	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
331272013050	putative active site [active]
331272013051	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272013052	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
331272013053	Walker A/P-loop; other site
331272013054	ATP binding site [chemical binding]; other site
331272013055	Q-loop/lid; other site
331272013056	ABC transporter signature motif; other site
331272013057	Walker B; other site
331272013058	D-loop; other site
331272013059	H-loop/switch region; other site
331272013060	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
331272013061	putative acyl-acceptor binding pocket; other site
331272013062	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
331272013063	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272013064	OmpW family; Region: OmpW; cl17427
331272013065	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
331272013066	Uncharacterized conserved protein [Function unknown]; Region: COG1739
331272013067	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
331272013068	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
331272013069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272013071	dimerization interface [polypeptide binding]; other site
331272013072	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
331272013073	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
331272013074	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
331272013075	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
331272013076	polysaccharide export protein Wza; Provisional; Region: PRK15078
331272013077	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
331272013078	SLBB domain; Region: SLBB; pfam10531
331272013079	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
331272013080	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272013081	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272013082	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
331272013083	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
331272013084	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
331272013085	Chain length determinant protein; Region: Wzz; pfam02706
331272013086	tyrosine kinase; Provisional; Region: PRK11519
331272013087	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
331272013088	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
331272013089	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
331272013090	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
331272013091	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
331272013092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272013093	putative ADP-binding pocket [chemical binding]; other site
331272013094	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
331272013095	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
331272013096	Substrate binding site; other site
331272013097	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
331272013098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272013099	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272013100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272013101	Walker A motif; other site
331272013102	ATP binding site [chemical binding]; other site
331272013103	Walker B motif; other site
331272013104	arginine finger; other site
331272013105	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272013106	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
331272013107	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
331272013108	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
331272013109	dimer interface [polypeptide binding]; other site
331272013110	motif 1; other site
331272013111	active site
331272013112	motif 2; other site
331272013113	motif 3; other site
331272013114	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272013115	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
331272013116	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272013117	active site
331272013118	acyl carrier protein; Provisional; Region: PRK07081
331272013119	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272013120	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272013121	ligand binding site [chemical binding]; other site
331272013122	flexible hinge region; other site
331272013123	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
331272013124	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272013125	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
331272013126	non-specific DNA interactions [nucleotide binding]; other site
331272013127	DNA binding site [nucleotide binding]
331272013128	sequence specific DNA binding site [nucleotide binding]; other site
331272013129	putative cAMP binding site [chemical binding]; other site
331272013130	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
331272013131	Bacterial sugar transferase; Region: Bac_transf; pfam02397
331272013132	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
331272013133	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
331272013134	hypothetical protein; Provisional; Region: PRK08609
331272013135	active site
331272013136	primer binding site [nucleotide binding]; other site
331272013137	NTP  binding site [chemical binding]; other site
331272013138	metal binding triad [ion binding]; metal-binding site
331272013139	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
331272013140	active site
331272013141	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
331272013142	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
331272013143	hexamer interface [polypeptide binding]; other site
331272013144	ligand binding site [chemical binding]; other site
331272013145	putative active site [active]
331272013146	NAD(P) binding site [chemical binding]; other site
331272013147	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
331272013148	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
331272013149	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
331272013150	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331272013151	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272013152	Cytochrome c; Region: Cytochrom_C; pfam00034
331272013153	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013154	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013155	Cytochrome c; Region: Cytochrom_C; pfam00034
331272013156	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
331272013157	putative cation:proton antiport protein; Provisional; Region: PRK10669
331272013158	TrkA-N domain; Region: TrkA_N; pfam02254
331272013159	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
331272013160	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
331272013161	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
331272013162	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
331272013163	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
331272013164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272013165	NAD(P) binding site [chemical binding]; other site
331272013166	active site
331272013167	MarR family; Region: MarR_2; cl17246
331272013168	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272013169	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
331272013170	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
331272013171	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272013172	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
331272013173	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
331272013174	NAD binding site [chemical binding]; other site
331272013175	catalytic residues [active]
331272013176	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
331272013177	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
331272013178	putative active site [active]
331272013179	putative metal binding site [ion binding]; other site
331272013180	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
331272013181	putative substrate binding pocket [chemical binding]; other site
331272013182	trimer interface [polypeptide binding]; other site
331272013183	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
331272013184	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
331272013185	Cupin domain; Region: Cupin_2; cl17218
331272013186	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272013187	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013188	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272013189	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
331272013190	NAD(P) binding site [chemical binding]; other site
331272013191	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272013192	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272013193	trimer interface [polypeptide binding]; other site
331272013194	eyelet of channel; other site
331272013195	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
331272013196	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272013197	Walker A/P-loop; other site
331272013198	ATP binding site [chemical binding]; other site
331272013199	Q-loop/lid; other site
331272013200	ABC transporter signature motif; other site
331272013201	Walker B; other site
331272013202	D-loop; other site
331272013203	H-loop/switch region; other site
331272013204	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
331272013205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013206	dimer interface [polypeptide binding]; other site
331272013207	conserved gate region; other site
331272013208	ABC-ATPase subunit interface; other site
331272013209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013210	dimer interface [polypeptide binding]; other site
331272013211	conserved gate region; other site
331272013212	putative PBP binding loops; other site
331272013213	ABC-ATPase subunit interface; other site
331272013214	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272013215	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272013216	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272013217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272013218	DNA-binding site [nucleotide binding]; DNA binding site
331272013219	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272013220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013221	homodimer interface [polypeptide binding]; other site
331272013222	catalytic residue [active]
331272013223	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
331272013224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013225	putative substrate translocation pore; other site
331272013226	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
331272013227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013228	active site
331272013229	phosphorylation site [posttranslational modification]
331272013230	intermolecular recognition site; other site
331272013231	dimerization interface [polypeptide binding]; other site
331272013232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272013233	DNA binding site [nucleotide binding]
331272013234	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
331272013235	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
331272013236	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272013237	dimer interface [polypeptide binding]; other site
331272013238	phosphorylation site [posttranslational modification]
331272013239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272013240	ATP binding site [chemical binding]; other site
331272013241	Mg2+ binding site [ion binding]; other site
331272013242	G-X-G motif; other site
331272013243	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
331272013244	MOSC domain; Region: MOSC; pfam03473
331272013245	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272013246	membrane-bound complex binding site; other site
331272013247	Cytochrome c; Region: Cytochrom_C; pfam00034
331272013248	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272013249	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272013250	Walker A/P-loop; other site
331272013251	ATP binding site [chemical binding]; other site
331272013252	Q-loop/lid; other site
331272013253	ABC transporter signature motif; other site
331272013254	Walker B; other site
331272013255	D-loop; other site
331272013256	H-loop/switch region; other site
331272013257	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272013258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013259	dimer interface [polypeptide binding]; other site
331272013260	conserved gate region; other site
331272013261	putative PBP binding loops; other site
331272013262	ABC-ATPase subunit interface; other site
331272013263	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272013264	NMT1/THI5 like; Region: NMT1; pfam09084
331272013265	hypothetical protein; Provisional; Region: PRK06208
331272013266	active site
331272013267	intersubunit interface [polypeptide binding]; other site
331272013268	Zn2+ binding site [ion binding]; other site
331272013269	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
331272013270	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
331272013271	dimer interface [polypeptide binding]; other site
331272013272	active site
331272013273	non-prolyl cis peptide bond; other site
331272013274	insertion regions; other site
331272013275	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272013276	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
331272013277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272013278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013279	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272013280	dimerization interface [polypeptide binding]; other site
331272013281	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
331272013282	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
331272013283	active site residue [active]
331272013284	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
331272013285	active site residue [active]
331272013286	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
331272013287	active site residue [active]
331272013288	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
331272013289	active site residue [active]
331272013290	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
331272013291	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
331272013292	putative active site [active]
331272013293	catalytic site [active]
331272013294	putative metal binding site [ion binding]; other site
331272013295	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
331272013296	active site lid residues [active]
331272013297	substrate binding pocket [chemical binding]; other site
331272013298	catalytic residues [active]
331272013299	substrate-Mg2+ binding site; other site
331272013300	aspartate-rich region 1; other site
331272013301	aspartate-rich region 2; other site
331272013302	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272013303	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272013304	trimer interface [polypeptide binding]; other site
331272013305	eyelet of channel; other site
331272013306	Cupin domain; Region: Cupin_2; pfam07883
331272013307	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272013308	Uncharacterized conserved protein [Function unknown]; Region: COG2128
331272013309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272013310	DNA-binding site [nucleotide binding]; DNA binding site
331272013311	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272013312	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272013313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013314	homodimer interface [polypeptide binding]; other site
331272013315	catalytic residue [active]
331272013316	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
331272013317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013318	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272013319	dimerization interface [polypeptide binding]; other site
331272013320	short chain dehydrogenase; Provisional; Region: PRK06500
331272013321	classical (c) SDRs; Region: SDR_c; cd05233
331272013322	NAD(P) binding site [chemical binding]; other site
331272013323	active site
331272013324	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
331272013325	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
331272013326	substrate binding [chemical binding]; other site
331272013327	active site
331272013328	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
331272013329	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
331272013330	active site
331272013331	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272013332	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272013333	DNA binding site [nucleotide binding]
331272013334	domain linker motif; other site
331272013335	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
331272013336	ligand binding site [chemical binding]; other site
331272013337	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272013338	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
331272013339	potential catalytic triad [active]
331272013340	conserved cys residue [active]
331272013341	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272013342	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
331272013343	active site
331272013344	FMN binding site [chemical binding]; other site
331272013345	substrate binding site [chemical binding]; other site
331272013346	homotetramer interface [polypeptide binding]; other site
331272013347	catalytic residue [active]
331272013348	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
331272013349	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
331272013350	short chain dehydrogenase; Provisional; Region: PRK06523
331272013351	classical (c) SDRs; Region: SDR_c; cd05233
331272013352	NAD(P) binding site [chemical binding]; other site
331272013353	active site
331272013354	Inclusion body protein; Region: PixA; pfam12306
331272013355	Inclusion body protein; Region: PixA; pfam12306
331272013356	Inclusion body protein; Region: PixA; pfam12306
331272013357	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272013358	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272013359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013361	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272013362	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
331272013363	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
331272013364	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
331272013365	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
331272013366	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
331272013367	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
331272013368	putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
331272013369	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
331272013370	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
331272013371	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
331272013372	amidase; Provisional; Region: PRK07235
331272013373	amidase; Provisional; Region: PRK07487
331272013374	Cupin domain; Region: Cupin_2; cl17218
331272013375	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272013376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013377	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
331272013378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
331272013379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272013380	dimer interface [polypeptide binding]; other site
331272013381	phosphorylation site [posttranslational modification]
331272013382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272013383	ATP binding site [chemical binding]; other site
331272013384	Mg2+ binding site [ion binding]; other site
331272013385	G-X-G motif; other site
331272013386	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
331272013387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013388	active site
331272013389	phosphorylation site [posttranslational modification]
331272013390	intermolecular recognition site; other site
331272013391	dimerization interface [polypeptide binding]; other site
331272013392	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272013393	DNA binding site [nucleotide binding]
331272013394	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272013395	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272013396	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272013397	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272013398	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272013399	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272013400	ligand binding site [chemical binding]; other site
331272013401	flexible hinge region; other site
331272013402	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
331272013403	acyl-CoA synthetase; Validated; Region: PRK08162
331272013404	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
331272013405	acyl-activating enzyme (AAE) consensus motif; other site
331272013406	putative active site [active]
331272013407	AMP binding site [chemical binding]; other site
331272013408	putative CoA binding site [chemical binding]; other site
331272013409	Cache domain; Region: Cache_1; pfam02743
331272013410	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272013411	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272013412	dimer interface [polypeptide binding]; other site
331272013413	putative CheW interface [polypeptide binding]; other site
331272013414	Predicted membrane protein [Function unknown]; Region: COG1238
331272013415	voltage-gated potassium channel; Provisional; Region: PRK10537
331272013416	Ion channel; Region: Ion_trans_2; pfam07885
331272013417	TrkA-N domain; Region: TrkA_N; pfam02254
331272013418	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272013419	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272013420	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
331272013421	putative DNA binding site [nucleotide binding]; other site
331272013422	putative Zn2+ binding site [ion binding]; other site
331272013423	AsnC family; Region: AsnC_trans_reg; pfam01037
331272013424	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272013425	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
331272013426	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272013427	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272013428	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
331272013429	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272013430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013431	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
331272013432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272013433	NAD(P) binding site [chemical binding]; other site
331272013434	active site
331272013435	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272013436	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272013437	conserved cys residue [active]
331272013438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013439	Epoxide hydrolase N terminus; Region: EHN; pfam06441
331272013440	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272013441	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
331272013442	MarR family; Region: MarR_2; pfam12802
331272013443	H+ Antiporter protein; Region: 2A0121; TIGR00900
331272013444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013445	putative substrate translocation pore; other site
331272013446	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272013447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013448	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272013449	dimerization interface [polypeptide binding]; other site
331272013450	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
331272013451	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272013452	inhibitor-cofactor binding pocket; inhibition site
331272013453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013454	catalytic residue [active]
331272013455	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
331272013456	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
331272013457	tetrameric interface [polypeptide binding]; other site
331272013458	NAD binding site [chemical binding]; other site
331272013459	catalytic residues [active]
331272013460	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
331272013461	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
331272013462	EamA-like transporter family; Region: EamA; pfam00892
331272013463	EamA-like transporter family; Region: EamA; pfam00892
331272013464	Predicted permeases [General function prediction only]; Region: COG0679
331272013465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272013466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013467	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
331272013468	putative dimerization interface [polypeptide binding]; other site
331272013469	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272013470	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272013471	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272013472	DNA binding residues [nucleotide binding]
331272013473	dimerization interface [polypeptide binding]; other site
331272013474	amino acid transporter; Region: 2A0306; TIGR00909
331272013475	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
331272013476	homodimer interface [polypeptide binding]; other site
331272013477	homotetramer interface [polypeptide binding]; other site
331272013478	active site pocket [active]
331272013479	cleavage site
331272013480	Fusaric acid resistance protein family; Region: FUSC; pfam04632
331272013481	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272013482	transcriptional regulator; Provisional; Region: PRK10632
331272013483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013484	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272013485	putative effector binding pocket; other site
331272013486	dimerization interface [polypeptide binding]; other site
331272013487	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272013488	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272013489	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272013490	trimer interface [polypeptide binding]; other site
331272013491	eyelet of channel; other site
331272013492	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
331272013493	cytosine deaminase; Provisional; Region: PRK09230
331272013494	active site
331272013495	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
331272013496	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
331272013497	putative ion selectivity filter; other site
331272013498	putative pore gating glutamate residue; other site
331272013499	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272013500	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272013501	non-specific DNA binding site [nucleotide binding]; other site
331272013502	salt bridge; other site
331272013503	sequence-specific DNA binding site [nucleotide binding]; other site
331272013504	HipA N-terminal domain; Region: Couple_hipA; pfam13657
331272013505	HipA-like N-terminal domain; Region: HipA_N; pfam07805
331272013506	HipA-like C-terminal domain; Region: HipA_C; pfam07804
331272013507	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272013508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013509	putative substrate translocation pore; other site
331272013510	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
331272013511	short chain dehydrogenase; Provisional; Region: PRK12829
331272013512	classical (c) SDRs; Region: SDR_c; cd05233
331272013513	NAD(P) binding site [chemical binding]; other site
331272013514	active site
331272013515	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272013516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
331272013517	FCD domain; Region: FCD; pfam07729
331272013518	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
331272013519	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272013520	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272013521	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272013522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272013523	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272013524	substrate binding pocket [chemical binding]; other site
331272013525	membrane-bound complex binding site; other site
331272013526	hinge residues; other site
331272013527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013528	dimer interface [polypeptide binding]; other site
331272013529	conserved gate region; other site
331272013530	putative PBP binding loops; other site
331272013531	ABC-ATPase subunit interface; other site
331272013532	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272013533	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272013534	Walker A/P-loop; other site
331272013535	ATP binding site [chemical binding]; other site
331272013536	Q-loop/lid; other site
331272013537	ABC transporter signature motif; other site
331272013538	Walker B; other site
331272013539	D-loop; other site
331272013540	H-loop/switch region; other site
331272013541	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272013542	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272013543	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272013544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272013545	S-adenosylmethionine binding site [chemical binding]; other site
331272013546	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
331272013547	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272013548	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
331272013549	EamA-like transporter family; Region: EamA; cl17759
331272013550	EamA-like transporter family; Region: EamA; pfam00892
331272013551	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272013552	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
331272013553	putative DNA binding site [nucleotide binding]; other site
331272013554	putative Zn2+ binding site [ion binding]; other site
331272013555	AsnC family; Region: AsnC_trans_reg; pfam01037
331272013556	aromatic amino acid transporter; Provisional; Region: PRK10238
331272013557	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
331272013558	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272013559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013560	homodimer interface [polypeptide binding]; other site
331272013561	catalytic residue [active]
331272013562	Protein of unknown function, DUF488; Region: DUF488; cl01246
331272013563	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
331272013564	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
331272013565	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272013566	ligand binding site [chemical binding]; other site
331272013567	flexible hinge region; other site
331272013568	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
331272013569	putative switch regulator; other site
331272013570	non-specific DNA interactions [nucleotide binding]; other site
331272013571	DNA binding site [nucleotide binding]
331272013572	sequence specific DNA binding site [nucleotide binding]; other site
331272013573	putative cAMP binding site [chemical binding]; other site
331272013574	Response regulator receiver domain; Region: Response_reg; pfam00072
331272013575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013576	active site
331272013577	phosphorylation site [posttranslational modification]
331272013578	intermolecular recognition site; other site
331272013579	dimerization interface [polypeptide binding]; other site
331272013580	ornithine cyclodeaminase; Validated; Region: PRK07340
331272013581	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
331272013582	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272013583	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272013584	DNA-binding site [nucleotide binding]; DNA binding site
331272013585	FCD domain; Region: FCD; pfam07729
331272013586	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272013587	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272013588	dimerization interface [polypeptide binding]; other site
331272013589	ligand binding site [chemical binding]; other site
331272013590	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
331272013591	Proline racemase; Region: Pro_racemase; pfam05544
331272013592	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
331272013593	Transglycosylase; Region: Transgly; pfam00912
331272013594	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272013595	PilZ domain; Region: PilZ; pfam07238
331272013596	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272013597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
331272013598	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272013599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013600	active site
331272013601	phosphorylation site [posttranslational modification]
331272013602	intermolecular recognition site; other site
331272013603	dimerization interface [polypeptide binding]; other site
331272013604	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272013605	DNA binding residues [nucleotide binding]
331272013606	dimerization interface [polypeptide binding]; other site
331272013607	PAS domain S-box; Region: sensory_box; TIGR00229
331272013608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272013609	putative active site [active]
331272013610	heme pocket [chemical binding]; other site
331272013611	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
331272013612	Histidine kinase; Region: HisKA_3; pfam07730
331272013613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272013614	ATP binding site [chemical binding]; other site
331272013615	Mg2+ binding site [ion binding]; other site
331272013616	G-X-G motif; other site
331272013617	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272013618	Ligand Binding Site [chemical binding]; other site
331272013619	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
331272013620	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
331272013621	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
331272013622	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
331272013623	active site residue [active]
331272013624	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
331272013625	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272013626	Ligand Binding Site [chemical binding]; other site
331272013627	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272013628	Ligand Binding Site [chemical binding]; other site
331272013629	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
331272013630	Cache domain; Region: Cache_1; pfam02743
331272013631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272013632	dimerization interface [polypeptide binding]; other site
331272013633	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272013634	dimer interface [polypeptide binding]; other site
331272013635	putative CheW interface [polypeptide binding]; other site
331272013636	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
331272013637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272013638	Walker A motif; other site
331272013639	ATP binding site [chemical binding]; other site
331272013640	Walker B motif; other site
331272013641	arginine finger; other site
331272013642	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272013643	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331272013644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272013645	putative active site [active]
331272013646	heme pocket [chemical binding]; other site
331272013647	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272013648	dimer interface [polypeptide binding]; other site
331272013649	phosphorylation site [posttranslational modification]
331272013650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272013651	ATP binding site [chemical binding]; other site
331272013652	G-X-G motif; other site
331272013653	Response regulator receiver domain; Region: Response_reg; pfam00072
331272013654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013655	active site
331272013656	phosphorylation site [posttranslational modification]
331272013657	intermolecular recognition site; other site
331272013658	dimerization interface [polypeptide binding]; other site
331272013659	BON domain; Region: BON; pfam04972
331272013660	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
331272013661	PRC-barrel domain; Region: PRC; pfam05239
331272013662	FOG: CBS domain [General function prediction only]; Region: COG0517
331272013663	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
331272013664	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
331272013665	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
331272013666	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
331272013667	DEAD_2; Region: DEAD_2; pfam06733
331272013668	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
331272013669	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
331272013670	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
331272013671	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272013672	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
331272013673	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
331272013674	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
331272013675	putative active site [active]
331272013676	shikimate transporter; Provisional; Region: PRK09952
331272013677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013678	putative substrate translocation pore; other site
331272013679	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
331272013680	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
331272013681	dimer interface [polypeptide binding]; other site
331272013682	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
331272013683	active site
331272013684	Fe binding site [ion binding]; other site
331272013685	HipA N-terminal domain; Region: Couple_hipA; cl11853
331272013686	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
331272013687	HipA-like N-terminal domain; Region: HipA_N; pfam07805
331272013688	HipA-like C-terminal domain; Region: HipA_C; pfam07804
331272013689	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272013690	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272013691	salt bridge; other site
331272013692	non-specific DNA binding site [nucleotide binding]; other site
331272013693	sequence-specific DNA binding site [nucleotide binding]; other site
331272013694	Cation efflux family; Region: Cation_efflux; cl00316
331272013695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
331272013696	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272013697	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272013698	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
331272013699	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
331272013700	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272013701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272013702	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
331272013703	Prostaglandin dehydrogenases; Region: PGDH; cd05288
331272013704	NAD(P) binding site [chemical binding]; other site
331272013705	substrate binding site [chemical binding]; other site
331272013706	dimer interface [polypeptide binding]; other site
331272013707	Uncharacterized conserved protein [Function unknown]; Region: COG1359
331272013708	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272013709	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272013710	catalytic loop [active]
331272013711	iron binding site [ion binding]; other site
331272013712	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272013713	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272013714	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272013715	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272013716	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272013717	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272013718	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013719	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
331272013720	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013721	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272013722	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331272013723	tetramerization interface [polypeptide binding]; other site
331272013724	NAD(P) binding site [chemical binding]; other site
331272013725	catalytic residues [active]
331272013726	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
331272013727	active site
331272013728	nucleophile elbow; other site
331272013729	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
331272013730	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
331272013731	putative dimer interface [polypeptide binding]; other site
331272013732	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272013733	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272013734	trimer interface [polypeptide binding]; other site
331272013735	eyelet of channel; other site
331272013736	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272013737	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272013738	ligand binding site [chemical binding]; other site
331272013739	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013740	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272013741	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
331272013742	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272013743	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272013744	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272013745	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272013746	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272013747	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272013748	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272013749	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272013750	PAS domain; Region: PAS; smart00091
331272013751	PAS fold; Region: PAS_7; pfam12860
331272013752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272013753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272013754	metal binding site [ion binding]; metal-binding site
331272013755	active site
331272013756	I-site; other site
331272013757	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
331272013758	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
331272013759	putative active site [active]
331272013760	Zn binding site [ion binding]; other site
331272013761	recombination associated protein; Reviewed; Region: rdgC; PRK00321
331272013762	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272013763	Coenzyme A binding pocket [chemical binding]; other site
331272013764	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272013765	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272013766	substrate binding pocket [chemical binding]; other site
331272013767	membrane-bound complex binding site; other site
331272013768	hinge residues; other site
331272013769	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
331272013770	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
331272013771	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
331272013772	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
331272013773	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
331272013774	active site
331272013775	non-prolyl cis peptide bond; other site
331272013776	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272013777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272013778	dimer interface [polypeptide binding]; other site
331272013779	conserved gate region; other site
331272013780	putative PBP binding loops; other site
331272013781	ABC-ATPase subunit interface; other site
331272013782	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272013783	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272013784	Walker A/P-loop; other site
331272013785	ATP binding site [chemical binding]; other site
331272013786	Q-loop/lid; other site
331272013787	ABC transporter signature motif; other site
331272013788	Walker B; other site
331272013789	D-loop; other site
331272013790	H-loop/switch region; other site
331272013791	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272013792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272013793	substrate binding pocket [chemical binding]; other site
331272013794	membrane-bound complex binding site; other site
331272013795	hinge residues; other site
331272013796	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
331272013797	active site
331272013798	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
331272013799	dimer interface [polypeptide binding]; other site
331272013800	non-prolyl cis peptide bond; other site
331272013801	insertion regions; other site
331272013802	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272013803	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272013804	substrate binding pocket [chemical binding]; other site
331272013805	membrane-bound complex binding site; other site
331272013806	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
331272013807	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272013808	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272013809	MarR family; Region: MarR; pfam01047
331272013810	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
331272013811	Asp-box motif; other site
331272013812	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
331272013813	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
331272013814	NAD binding site [chemical binding]; other site
331272013815	substrate binding site [chemical binding]; other site
331272013816	catalytic Zn binding site [ion binding]; other site
331272013817	tetramer interface [polypeptide binding]; other site
331272013818	structural Zn binding site [ion binding]; other site
331272013819	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
331272013820	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272013821	N-terminal plug; other site
331272013822	ligand-binding site [chemical binding]; other site
331272013823	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272013824	dimerization interface [polypeptide binding]; other site
331272013825	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272013826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272013827	dimer interface [polypeptide binding]; other site
331272013828	putative CheW interface [polypeptide binding]; other site
331272013829	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
331272013830	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
331272013831	active site
331272013832	homotetramer interface [polypeptide binding]; other site
331272013833	FtsH Extracellular; Region: FtsH_ext; pfam06480
331272013834	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
331272013835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272013836	Walker A motif; other site
331272013837	ATP binding site [chemical binding]; other site
331272013838	Walker B motif; other site
331272013839	arginine finger; other site
331272013840	Peptidase family M41; Region: Peptidase_M41; pfam01434
331272013841	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
331272013842	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
331272013843	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
331272013844	active site
331272013845	substrate-binding site [chemical binding]; other site
331272013846	metal-binding site [ion binding]
331272013847	GTP binding site [chemical binding]; other site
331272013848	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272013849	tetramer interface [polypeptide binding]; other site
331272013850	active site
331272013851	Mg2+/Mn2+ binding site [ion binding]; other site
331272013852	isocitrate lyase; Region: PLN02892
331272013853	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
331272013854	putative deacylase active site [active]
331272013855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
331272013856	YheO-like PAS domain; Region: PAS_6; pfam08348
331272013857	HTH domain; Region: HTH_22; pfam13309
331272013858	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
331272013859	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
331272013860	tetramer interface [polypeptide binding]; other site
331272013861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013862	catalytic residue [active]
331272013863	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
331272013864	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272013865	N-terminal plug; other site
331272013866	ligand-binding site [chemical binding]; other site
331272013867	LysE type translocator; Region: LysE; cl00565
331272013868	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272013869	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272013870	putative DNA binding site [nucleotide binding]; other site
331272013871	putative Zn2+ binding site [ion binding]; other site
331272013872	AsnC family; Region: AsnC_trans_reg; pfam01037
331272013873	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
331272013874	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
331272013875	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
331272013876	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272013877	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
331272013878	rRNA binding site [nucleotide binding]; other site
331272013879	predicted 30S ribosome binding site; other site
331272013880	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272013881	DNA-binding site [nucleotide binding]; DNA binding site
331272013882	RNA-binding motif; other site
331272013883	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
331272013884	oligomeric interface; other site
331272013885	putative active site [active]
331272013886	homodimer interface [polypeptide binding]; other site
331272013887	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
331272013888	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
331272013889	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
331272013890	putative transporter; Provisional; Region: PRK10504
331272013891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013892	putative substrate translocation pore; other site
331272013893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013894	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
331272013895	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
331272013896	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
331272013897	Int/Topo IB signature motif; other site
331272013898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
331272013899	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
331272013900	Heavy-metal resistance; Region: Metal_resist; pfam13801
331272013901	RNA polymerase sigma factor; Reviewed; Region: PRK05602
331272013902	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272013903	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272013904	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331272013905	active site
331272013906	metal binding site [ion binding]; metal-binding site
331272013907	aromatic amino acid exporter; Provisional; Region: PRK11689
331272013908	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272013909	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
331272013910	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013911	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272013912	dimerization interface [polypeptide binding]; other site
331272013913	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272013914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272013915	dimerization interface [polypeptide binding]; other site
331272013916	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272013917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272013918	metal binding site [ion binding]; metal-binding site
331272013919	active site
331272013920	I-site; other site
331272013921	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272013922	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272013923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272013924	DNA-binding site [nucleotide binding]; DNA binding site
331272013925	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272013926	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272013927	mannonate dehydratase; Region: uxuA; TIGR00695
331272013928	mannonate dehydratase; Provisional; Region: PRK03906
331272013929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013930	D-galactonate transporter; Region: 2A0114; TIGR00893
331272013931	putative substrate translocation pore; other site
331272013932	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272013933	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272013934	DNA-binding site [nucleotide binding]; DNA binding site
331272013935	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272013936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272013937	homodimer interface [polypeptide binding]; other site
331272013938	catalytic residue [active]
331272013939	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
331272013940	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
331272013941	Predicted integral membrane protein [Function unknown]; Region: COG0392
331272013942	Uncharacterized conserved protein [Function unknown]; Region: COG2898
331272013943	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
331272013944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272013945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272013946	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272013947	putative effector binding pocket; other site
331272013948	putative dimerization interface [polypeptide binding]; other site
331272013949	Domain of unknown function (DUF336); Region: DUF336; pfam03928
331272013950	short chain dehydrogenase; Provisional; Region: PRK09291
331272013951	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272013952	NADP binding site [chemical binding]; other site
331272013953	active site
331272013954	steroid binding site; other site
331272013955	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
331272013956	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
331272013957	[4Fe-4S] binding site [ion binding]; other site
331272013958	molybdopterin cofactor binding site; other site
331272013959	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
331272013960	molybdopterin cofactor binding site; other site
331272013961	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
331272013962	Flavodoxin; Region: Flavodoxin_1; pfam00258
331272013963	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
331272013964	FAD binding pocket [chemical binding]; other site
331272013965	FAD binding motif [chemical binding]; other site
331272013966	catalytic residues [active]
331272013967	NAD binding pocket [chemical binding]; other site
331272013968	phosphate binding motif [ion binding]; other site
331272013969	beta-alpha-beta structure motif; other site
331272013970	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
331272013971	nitrite reductase subunit NirD; Provisional; Region: PRK14989
331272013972	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272013973	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272013974	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
331272013975	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
331272013976	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
331272013977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272013978	putative substrate translocation pore; other site
331272013979	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
331272013980	active site
331272013981	SAM binding site [chemical binding]; other site
331272013982	homodimer interface [polypeptide binding]; other site
331272013983	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
331272013984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272013985	active site
331272013986	phosphorylation site [posttranslational modification]
331272013987	intermolecular recognition site; other site
331272013988	dimerization interface [polypeptide binding]; other site
331272013989	ANTAR domain; Region: ANTAR; pfam03861
331272013990	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272013991	NMT1-like family; Region: NMT1_2; pfam13379
331272013992	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
331272013993	putative uracil binding site [chemical binding]; other site
331272013994	putative active site [active]
331272013995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272013996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272013997	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272013998	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272013999	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
331272014000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014001	putative substrate translocation pore; other site
331272014002	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
331272014003	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331272014004	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272014005	protein binding site [polypeptide binding]; other site
331272014006	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
331272014007	protein binding site [polypeptide binding]; other site
331272014008	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272014009	DNA-binding site [nucleotide binding]; DNA binding site
331272014010	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272014011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272014012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272014013	homodimer interface [polypeptide binding]; other site
331272014014	catalytic residue [active]
331272014015	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272014016	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272014017	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272014018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272014019	Coenzyme A binding pocket [chemical binding]; other site
331272014020	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
331272014021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014022	putative substrate translocation pore; other site
331272014023	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272014024	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
331272014025	Coenzyme A binding pocket [chemical binding]; other site
331272014026	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272014027	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
331272014028	putative NAD(P) binding site [chemical binding]; other site
331272014029	catalytic Zn binding site [ion binding]; other site
331272014030	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272014031	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272014032	active site
331272014033	catalytic tetrad [active]
331272014034	MarC family integral membrane protein; Region: MarC; cl00919
331272014035	enoyl-CoA hydratase; Provisional; Region: PRK05995
331272014036	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272014037	substrate binding site [chemical binding]; other site
331272014038	oxyanion hole (OAH) forming residues; other site
331272014039	trimer interface [polypeptide binding]; other site
331272014040	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
331272014041	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
331272014042	active site
331272014043	AMP binding site [chemical binding]; other site
331272014044	homodimer interface [polypeptide binding]; other site
331272014045	acyl-activating enzyme (AAE) consensus motif; other site
331272014046	CoA binding site [chemical binding]; other site
331272014047	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
331272014048	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272014049	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272014050	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272014051	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
331272014052	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272014053	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272014054	active site
331272014055	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
331272014056	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
331272014057	putative ligand binding site [chemical binding]; other site
331272014058	putative NAD binding site [chemical binding]; other site
331272014059	catalytic site [active]
331272014060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272014061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272014062	DNA binding site [nucleotide binding]
331272014063	domain linker motif; other site
331272014064	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292
331272014065	putative dimerization interface [polypeptide binding]; other site
331272014066	putative ligand binding site [chemical binding]; other site
331272014067	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
331272014068	DctM-like transporters; Region: DctM; pfam06808
331272014069	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
331272014070	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
331272014071	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
331272014072	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272014073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014075	dimerization interface [polypeptide binding]; other site
331272014076	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
331272014077	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
331272014078	putative ligand binding site [chemical binding]; other site
331272014079	NAD binding site [chemical binding]; other site
331272014080	catalytic site [active]
331272014081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014082	D-galactonate transporter; Region: 2A0114; TIGR00893
331272014083	putative substrate translocation pore; other site
331272014084	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014086	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272014087	putative effector binding pocket; other site
331272014088	dimerization interface [polypeptide binding]; other site
331272014089	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
331272014090	HPP family; Region: HPP; pfam04982
331272014091	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
331272014092	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272014093	MarR family; Region: MarR_2; pfam12802
331272014094	MarR family; Region: MarR_2; cl17246
331272014095	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
331272014096	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
331272014097	Cl- selectivity filter; other site
331272014098	Cl- binding residues [ion binding]; other site
331272014099	pore gating glutamate residue; other site
331272014100	dimer interface [polypeptide binding]; other site
331272014101	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
331272014102	FOG: CBS domain [General function prediction only]; Region: COG0517
331272014103	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
331272014104	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
331272014105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014107	dimerization interface [polypeptide binding]; other site
331272014108	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272014109	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272014110	metal binding site [ion binding]; metal-binding site
331272014111	putative dimer interface [polypeptide binding]; other site
331272014112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014113	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272014114	putative substrate translocation pore; other site
331272014115	Isochorismatase family; Region: Isochorismatase; pfam00857
331272014116	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
331272014117	catalytic triad [active]
331272014118	conserved cis-peptide bond; other site
331272014119	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014120	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014121	trimer interface [polypeptide binding]; other site
331272014122	eyelet of channel; other site
331272014123	Predicted membrane protein [Function unknown]; Region: COG2259
331272014124	Cytochrome c; Region: Cytochrom_C; pfam00034
331272014125	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272014126	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272014127	Cytochrome c; Region: Cytochrom_C; pfam00034
331272014128	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331272014129	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272014130	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
331272014131	Bacterial Ig-like domain; Region: Big_5; pfam13205
331272014132	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
331272014133	MG2 domain; Region: A2M_N; pfam01835
331272014134	Alpha-2-macroglobulin family; Region: A2M; pfam00207
331272014135	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
331272014136	Transglycosylase; Region: Transgly; pfam00912
331272014137	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272014138	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
331272014139	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272014140	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272014141	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
331272014142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014143	putative substrate translocation pore; other site
331272014144	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331272014145	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272014146	substrate binding pocket [chemical binding]; other site
331272014147	membrane-bound complex binding site; other site
331272014148	hinge residues; other site
331272014149	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
331272014150	active site
331272014151	catalytic triad [active]
331272014152	magnesium-transporting ATPase; Provisional; Region: PRK15122
331272014153	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
331272014154	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331272014155	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
331272014156	Soluble P-type ATPase [General function prediction only]; Region: COG4087
331272014157	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
331272014158	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272014159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014160	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272014161	dimerization interface [polypeptide binding]; other site
331272014162	substrate binding pocket [chemical binding]; other site
331272014163	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
331272014164	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
331272014165	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272014166	MarR family; Region: MarR; pfam01047
331272014167	Isochorismatase family; Region: Isochorismatase; pfam00857
331272014168	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
331272014169	catalytic triad [active]
331272014170	conserved cis-peptide bond; other site
331272014171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014172	putative substrate translocation pore; other site
331272014173	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272014174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014177	dimerization interface [polypeptide binding]; other site
331272014178	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
331272014179	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
331272014180	Sulfate transporter family; Region: Sulfate_transp; pfam00916
331272014181	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
331272014182	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272014183	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272014184	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272014185	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272014186	DNA-binding site [nucleotide binding]; DNA binding site
331272014187	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272014188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272014189	homodimer interface [polypeptide binding]; other site
331272014190	catalytic residue [active]
331272014191	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
331272014192	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
331272014193	putative molybdopterin cofactor binding site [chemical binding]; other site
331272014194	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
331272014195	putative molybdopterin cofactor binding site; other site
331272014196	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
331272014197	Fusaric acid resistance protein family; Region: FUSC; pfam04632
331272014198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014200	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272014201	putative effector binding pocket; other site
331272014202	dimerization interface [polypeptide binding]; other site
331272014203	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272014204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014205	putative substrate translocation pore; other site
331272014206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014207	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
331272014208	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
331272014209	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
331272014210	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
331272014211	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
331272014212	Cupin; Region: Cupin_1; smart00835
331272014213	Cupin; Region: Cupin_1; smart00835
331272014214	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272014215	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272014216	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
331272014217	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
331272014218	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
331272014219	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
331272014220	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
331272014221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014222	dimer interface [polypeptide binding]; other site
331272014223	conserved gate region; other site
331272014224	putative PBP binding loops; other site
331272014225	ABC-ATPase subunit interface; other site
331272014226	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
331272014227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014228	dimer interface [polypeptide binding]; other site
331272014229	conserved gate region; other site
331272014230	putative PBP binding loops; other site
331272014231	ABC-ATPase subunit interface; other site
331272014232	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
331272014233	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272014234	Walker A/P-loop; other site
331272014235	ATP binding site [chemical binding]; other site
331272014236	Q-loop/lid; other site
331272014237	ABC transporter signature motif; other site
331272014238	Walker B; other site
331272014239	D-loop; other site
331272014240	H-loop/switch region; other site
331272014241	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
331272014242	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272014243	Walker A/P-loop; other site
331272014244	ATP binding site [chemical binding]; other site
331272014245	Q-loop/lid; other site
331272014246	ABC transporter signature motif; other site
331272014247	Walker B; other site
331272014248	D-loop; other site
331272014249	H-loop/switch region; other site
331272014250	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
331272014251	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272014252	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014253	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272014254	substrate binding pocket [chemical binding]; other site
331272014255	dimerization interface [polypeptide binding]; other site
331272014256	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
331272014257	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
331272014258	Peptidase family M23; Region: Peptidase_M23; pfam01551
331272014259	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014261	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
331272014262	putative dimerization interface [polypeptide binding]; other site
331272014263	Predicted ester cyclase [General function prediction only]; Region: COG5485
331272014264	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272014265	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272014266	active site
331272014267	catalytic tetrad [active]
331272014268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014270	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272014271	putative effector binding pocket; other site
331272014272	putative dimerization interface [polypeptide binding]; other site
331272014273	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014274	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014275	trimer interface [polypeptide binding]; other site
331272014276	eyelet of channel; other site
331272014277	OpgC protein; Region: OpgC_C; pfam10129
331272014278	S-formylglutathione hydrolase; Region: PLN02442
331272014279	Putative esterase; Region: Esterase; pfam00756
331272014280	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331272014281	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272014282	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
331272014283	Cytochrome c; Region: Cytochrom_C; pfam00034
331272014284	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272014285	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272014286	Cytochrome c; Region: Cytochrom_C; pfam00034
331272014287	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
331272014288	classical (c) SDRs; Region: SDR_c; cd05233
331272014289	NAD(P) binding site [chemical binding]; other site
331272014290	active site
331272014291	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014292	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014293	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272014294	putative effector binding pocket; other site
331272014295	dimerization interface [polypeptide binding]; other site
331272014296	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272014297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014298	active site
331272014299	phosphorylation site [posttranslational modification]
331272014300	intermolecular recognition site; other site
331272014301	dimerization interface [polypeptide binding]; other site
331272014302	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272014303	DNA binding site [nucleotide binding]
331272014304	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272014305	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272014306	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272014307	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272014308	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014309	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014310	trimer interface [polypeptide binding]; other site
331272014311	eyelet of channel; other site
331272014312	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272014313	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272014314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
331272014315	active site
331272014316	phosphorylation site [posttranslational modification]
331272014317	intermolecular recognition site; other site
331272014318	dimerization interface [polypeptide binding]; other site
331272014319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272014320	DNA binding site [nucleotide binding]
331272014321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272014322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272014323	dimerization interface [polypeptide binding]; other site
331272014324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272014325	ATP binding site [chemical binding]; other site
331272014326	Mg2+ binding site [ion binding]; other site
331272014327	G-X-G motif; other site
331272014328	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272014329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014330	active site
331272014331	phosphorylation site [posttranslational modification]
331272014332	intermolecular recognition site; other site
331272014333	dimerization interface [polypeptide binding]; other site
331272014334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272014335	DNA binding site [nucleotide binding]
331272014336	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272014337	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014338	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014339	trimer interface [polypeptide binding]; other site
331272014340	eyelet of channel; other site
331272014341	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
331272014342	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
331272014343	multimer interface [polypeptide binding]; other site
331272014344	active site
331272014345	catalytic triad [active]
331272014346	dimer interface [polypeptide binding]; other site
331272014347	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
331272014348	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
331272014349	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
331272014350	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272014351	Walker A/P-loop; other site
331272014352	ATP binding site [chemical binding]; other site
331272014353	Q-loop/lid; other site
331272014354	ABC transporter signature motif; other site
331272014355	Walker B; other site
331272014356	D-loop; other site
331272014357	H-loop/switch region; other site
331272014358	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
331272014359	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272014360	Walker A/P-loop; other site
331272014361	ATP binding site [chemical binding]; other site
331272014362	Q-loop/lid; other site
331272014363	ABC transporter signature motif; other site
331272014364	Walker B; other site
331272014365	D-loop; other site
331272014366	H-loop/switch region; other site
331272014367	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272014368	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272014369	TM-ABC transporter signature motif; other site
331272014370	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272014371	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272014372	TM-ABC transporter signature motif; other site
331272014373	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
331272014374	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
331272014375	putative ligand binding site [chemical binding]; other site
331272014376	Na binding site [ion binding]; other site
331272014377	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
331272014378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272014379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272014380	dimer interface [polypeptide binding]; other site
331272014381	phosphorylation site [posttranslational modification]
331272014382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272014383	ATP binding site [chemical binding]; other site
331272014384	Mg2+ binding site [ion binding]; other site
331272014385	G-X-G motif; other site
331272014386	Response regulator receiver domain; Region: Response_reg; pfam00072
331272014387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014388	active site
331272014389	phosphorylation site [posttranslational modification]
331272014390	intermolecular recognition site; other site
331272014391	dimerization interface [polypeptide binding]; other site
331272014392	Response regulator receiver domain; Region: Response_reg; pfam00072
331272014393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014394	active site
331272014395	phosphorylation site [posttranslational modification]
331272014396	intermolecular recognition site; other site
331272014397	dimerization interface [polypeptide binding]; other site
331272014398	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272014399	DNA binding residues [nucleotide binding]
331272014400	dimerization interface [polypeptide binding]; other site
331272014401	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
331272014402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014403	putative substrate translocation pore; other site
331272014404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014405	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
331272014406	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272014407	motif II; other site
331272014408	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
331272014409	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
331272014410	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
331272014411	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272014412	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
331272014413	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
331272014414	homodimer interface [polypeptide binding]; other site
331272014415	substrate-cofactor binding pocket; other site
331272014416	catalytic residue [active]
331272014417	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272014418	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272014419	putative DNA binding site [nucleotide binding]; other site
331272014420	putative Zn2+ binding site [ion binding]; other site
331272014421	AsnC family; Region: AsnC_trans_reg; pfam01037
331272014422	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
331272014423	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
331272014424	NADP binding site [chemical binding]; other site
331272014425	dimer interface [polypeptide binding]; other site
331272014426	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272014427	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272014428	active site
331272014429	catalytic tetrad [active]
331272014430	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272014431	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272014432	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014436	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272014437	putative dimerization interface [polypeptide binding]; other site
331272014438	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
331272014439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014440	D-galactonate transporter; Region: 2A0114; TIGR00893
331272014441	putative substrate translocation pore; other site
331272014442	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331272014443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272014444	substrate binding pocket [chemical binding]; other site
331272014445	membrane-bound complex binding site; other site
331272014446	hinge residues; other site
331272014447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272014449	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272014450	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272014451	metal binding site [ion binding]; metal-binding site
331272014452	putative dimer interface [polypeptide binding]; other site
331272014453	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
331272014454	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272014455	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272014456	NAD(P) binding site [chemical binding]; other site
331272014457	catalytic residues [active]
331272014458	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272014459	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272014460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014463	dimerization interface [polypeptide binding]; other site
331272014464	Ion channel; Region: Ion_trans_2; pfam07885
331272014465	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
331272014466	TrkA-N domain; Region: TrkA_N; pfam02254
331272014467	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272014468	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272014469	BetR domain; Region: BetR; pfam08667
331272014470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014471	active site
331272014472	phosphorylation site [posttranslational modification]
331272014473	intermolecular recognition site; other site
331272014474	dimerization interface [polypeptide binding]; other site
331272014475	Part of AAA domain; Region: AAA_19; pfam13245
331272014476	Family description; Region: UvrD_C_2; pfam13538
331272014477	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272014478	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
331272014479	dimer interface [polypeptide binding]; other site
331272014480	ligand binding site [chemical binding]; other site
331272014481	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272014482	dimerization interface [polypeptide binding]; other site
331272014483	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272014484	dimer interface [polypeptide binding]; other site
331272014485	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
331272014486	putative CheW interface [polypeptide binding]; other site
331272014487	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
331272014488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014489	putative substrate translocation pore; other site
331272014490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014491	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
331272014492	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
331272014493	NADP binding site [chemical binding]; other site
331272014494	dimer interface [polypeptide binding]; other site
331272014495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014497	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014498	dimerization interface [polypeptide binding]; other site
331272014499	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
331272014500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272014501	Coenzyme A binding pocket [chemical binding]; other site
331272014502	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
331272014503	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331272014504	DNA binding residues [nucleotide binding]
331272014505	putative dimer interface [polypeptide binding]; other site
331272014506	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272014507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272014508	substrate binding pocket [chemical binding]; other site
331272014509	membrane-bound complex binding site; other site
331272014510	hinge residues; other site
331272014511	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
331272014512	oligomer interface [polypeptide binding]; other site
331272014513	putative active site [active]
331272014514	Mn binding site [ion binding]; other site
331272014515	YhhN-like protein; Region: YhhN; pfam07947
331272014516	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
331272014517	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
331272014518	short chain dehydrogenase; Provisional; Region: PRK07832
331272014519	classical (c) SDRs; Region: SDR_c; cd05233
331272014520	NAD(P) binding site [chemical binding]; other site
331272014521	active site
331272014522	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
331272014523	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
331272014524	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272014525	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272014526	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
331272014527	Urea transporter; Region: UT; cl01829
331272014528	aldolase II superfamily protein; Provisional; Region: PRK07044
331272014529	intersubunit interface [polypeptide binding]; other site
331272014530	active site
331272014531	Zn2+ binding site [ion binding]; other site
331272014532	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
331272014533	active site 1 [active]
331272014534	dimer interface [polypeptide binding]; other site
331272014535	hexamer interface [polypeptide binding]; other site
331272014536	active site 2 [active]
331272014537	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
331272014538	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
331272014539	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
331272014540	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
331272014541	active site
331272014542	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
331272014543	amidase; Provisional; Region: PRK07486
331272014544	Amidase; Region: Amidase; pfam01425
331272014545	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272014546	Ligand Binding Site [chemical binding]; other site
331272014547	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272014548	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
331272014549	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
331272014550	conserved cys residue [active]
331272014551	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
331272014552	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
331272014553	substrate binding site [chemical binding]; other site
331272014554	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
331272014555	substrate binding site [chemical binding]; other site
331272014556	ligand binding site [chemical binding]; other site
331272014557	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
331272014558	trimer interface [polypeptide binding]; other site
331272014559	putative Zn binding site [ion binding]; other site
331272014560	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272014561	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272014562	benzoate transport; Region: 2A0115; TIGR00895
331272014563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014564	putative substrate translocation pore; other site
331272014565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014566	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
331272014567	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272014568	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272014569	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331272014570	active site
331272014571	metal binding site [ion binding]; metal-binding site
331272014572	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
331272014573	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272014574	putative active site [active]
331272014575	putative metal binding site [ion binding]; other site
331272014576	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272014577	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
331272014578	NAD(P) binding site [chemical binding]; other site
331272014579	catalytic residues [active]
331272014580	L-aspartate dehydrogenase; Provisional; Region: PRK13303
331272014581	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
331272014582	Domain of unknown function DUF108; Region: DUF108; pfam01958
331272014583	hypothetical protein; Provisional; Region: PRK07064
331272014584	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272014585	PYR/PP interface [polypeptide binding]; other site
331272014586	dimer interface [polypeptide binding]; other site
331272014587	TPP binding site [chemical binding]; other site
331272014588	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272014589	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
331272014590	TPP-binding site [chemical binding]; other site
331272014591	short chain dehydrogenase; Provisional; Region: PRK07062
331272014592	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
331272014593	putative NAD(P) binding site [chemical binding]; other site
331272014594	putative active site [active]
331272014595	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272014596	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272014597	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272014598	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272014599	Cupin domain; Region: Cupin_2; pfam07883
331272014600	short chain dehydrogenase; Provisional; Region: PRK12939
331272014601	classical (c) SDRs; Region: SDR_c; cd05233
331272014602	NAD(P) binding site [chemical binding]; other site
331272014603	active site
331272014604	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272014605	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272014606	[2Fe-2S] cluster binding site [ion binding]; other site
331272014607	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
331272014608	hydrophobic ligand binding site; other site
331272014609	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
331272014610	[2Fe-2S] cluster binding site [ion binding]; other site
331272014611	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014612	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014613	trimer interface [polypeptide binding]; other site
331272014614	eyelet of channel; other site
331272014615	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272014616	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272014617	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272014618	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
331272014619	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
331272014620	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272014621	putative active site [active]
331272014622	putative metal binding site [ion binding]; other site
331272014623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014625	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
331272014626	putative dimerization interface [polypeptide binding]; other site
331272014627	multidrug resistance protein MdtN; Provisional; Region: PRK10476
331272014628	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272014629	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272014630	Fusaric acid resistance protein family; Region: FUSC; pfam04632
331272014631	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272014632	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331272014633	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
331272014634	MgtC family; Region: MgtC; pfam02308
331272014635	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
331272014636	Autoinducer binding domain; Region: Autoind_bind; pfam03472
331272014637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272014638	DNA binding residues [nucleotide binding]
331272014639	dimerization interface [polypeptide binding]; other site
331272014640	Autoinducer synthetase; Region: Autoind_synth; cl17404
331272014641	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
331272014642	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331272014643	active site
331272014644	metal binding site [ion binding]; metal-binding site
331272014645	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272014646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272014647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272014648	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
331272014649	dimerization interface [polypeptide binding]; other site
331272014650	active site
331272014651	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
331272014652	FOG: CBS domain [General function prediction only]; Region: COG0517
331272014653	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272014654	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
331272014655	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
331272014656	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014657	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014658	trimer interface [polypeptide binding]; other site
331272014659	eyelet of channel; other site
331272014660	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272014661	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272014662	dimerization interface [polypeptide binding]; other site
331272014663	putative DNA binding site [nucleotide binding]; other site
331272014664	putative Zn2+ binding site [ion binding]; other site
331272014665	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331272014666	Isochorismatase family; Region: Isochorismatase; pfam00857
331272014667	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
331272014668	catalytic triad [active]
331272014669	conserved cis-peptide bond; other site
331272014670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014671	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272014672	putative substrate translocation pore; other site
331272014673	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
331272014674	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
331272014675	C-terminal domain interface [polypeptide binding]; other site
331272014676	GSH binding site (G-site) [chemical binding]; other site
331272014677	dimer interface [polypeptide binding]; other site
331272014678	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
331272014679	N-terminal domain interface [polypeptide binding]; other site
331272014680	dimer interface [polypeptide binding]; other site
331272014681	substrate binding pocket (H-site) [chemical binding]; other site
331272014682	MarR family; Region: MarR_2; cl17246
331272014683	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272014684	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272014685	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272014686	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272014687	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272014688	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
331272014689	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
331272014690	DNA binding residues [nucleotide binding]
331272014691	dimer interface [polypeptide binding]; other site
331272014692	[2Fe-2S] cluster binding site [ion binding]; other site
331272014693	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
331272014694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272014695	NAD(P) binding site [chemical binding]; other site
331272014696	active site
331272014697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014699	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272014700	dimerization interface [polypeptide binding]; other site
331272014701	substrate binding pocket [chemical binding]; other site
331272014702	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
331272014703	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272014704	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
331272014705	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272014706	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272014707	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
331272014708	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272014709	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
331272014710	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
331272014711	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
331272014712	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272014713	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272014714	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272014715	putative active site [active]
331272014716	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272014717	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272014718	Walker A/P-loop; other site
331272014719	ATP binding site [chemical binding]; other site
331272014720	Q-loop/lid; other site
331272014721	ABC transporter signature motif; other site
331272014722	Walker B; other site
331272014723	D-loop; other site
331272014724	H-loop/switch region; other site
331272014725	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
331272014726	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
331272014727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014728	dimer interface [polypeptide binding]; other site
331272014729	conserved gate region; other site
331272014730	putative PBP binding loops; other site
331272014731	ABC-ATPase subunit interface; other site
331272014732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014733	putative PBP binding loops; other site
331272014734	dimer interface [polypeptide binding]; other site
331272014735	ABC-ATPase subunit interface; other site
331272014736	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
331272014737	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272014738	active site
331272014739	metal binding site [ion binding]; metal-binding site
331272014740	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
331272014741	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
331272014742	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
331272014743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272014744	motif II; other site
331272014745	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272014746	dimerization interface [polypeptide binding]; other site
331272014747	putative DNA binding site [nucleotide binding]; other site
331272014748	putative Zn2+ binding site [ion binding]; other site
331272014749	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272014750	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272014751	FMN binding site [chemical binding]; other site
331272014752	active site
331272014753	substrate binding site [chemical binding]; other site
331272014754	catalytic residue [active]
331272014755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014756	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272014757	putative substrate translocation pore; other site
331272014758	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014759	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014760	trimer interface [polypeptide binding]; other site
331272014761	eyelet of channel; other site
331272014762	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272014763	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272014764	metal binding site [ion binding]; metal-binding site
331272014765	putative dimer interface [polypeptide binding]; other site
331272014766	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014768	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272014769	dimerization interface [polypeptide binding]; other site
331272014770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272014771	Coenzyme A binding pocket [chemical binding]; other site
331272014772	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
331272014773	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272014774	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272014775	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
331272014776	active site
331272014777	catalytic site [active]
331272014778	putative metal binding site [ion binding]; other site
331272014779	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272014780	DNA binding site [nucleotide binding]
331272014781	domain linker motif; other site
331272014782	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
331272014783	putative dimerization interface [polypeptide binding]; other site
331272014784	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272014785	putative ligand binding site [chemical binding]; other site
331272014786	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272014787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014788	dimer interface [polypeptide binding]; other site
331272014789	conserved gate region; other site
331272014790	putative PBP binding loops; other site
331272014791	ABC-ATPase subunit interface; other site
331272014792	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
331272014793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272014794	dimer interface [polypeptide binding]; other site
331272014795	conserved gate region; other site
331272014796	putative PBP binding loops; other site
331272014797	ABC-ATPase subunit interface; other site
331272014798	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272014799	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272014800	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272014801	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272014802	trimer interface [polypeptide binding]; other site
331272014803	eyelet of channel; other site
331272014804	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272014805	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014806	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
331272014807	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331272014808	hypothetical protein; Provisional; Region: PRK07481
331272014809	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272014810	inhibitor-cofactor binding pocket; inhibition site
331272014811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272014812	catalytic residue [active]
331272014813	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272014814	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272014815	NAD(P) binding site [chemical binding]; other site
331272014816	catalytic residues [active]
331272014817	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272014818	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272014819	DNA binding residues [nucleotide binding]
331272014820	dimerization interface [polypeptide binding]; other site
331272014821	Predicted metalloprotease [General function prediction only]; Region: COG2321
331272014822	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
331272014823	classical (c) SDRs; Region: SDR_c; cd05233
331272014824	NAD(P) binding site [chemical binding]; other site
331272014825	active site
331272014826	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014828	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272014829	dimerization interface [polypeptide binding]; other site
331272014830	carbamoyl-phosphate synthase; Region: PLN02735
331272014831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014832	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272014833	putative substrate translocation pore; other site
331272014834	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
331272014835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272014836	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272014837	NAD(P) binding site [chemical binding]; other site
331272014838	active site
331272014839	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014841	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272014842	putative effector binding pocket; other site
331272014843	dimerization interface [polypeptide binding]; other site
331272014844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272014845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272014846	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272014847	dimerization interface [polypeptide binding]; other site
331272014848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272014849	putative substrate translocation pore; other site
331272014850	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
331272014851	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
331272014852	homotrimer interaction site [polypeptide binding]; other site
331272014853	putative active site [active]
331272014854	inner membrane protein; Provisional; Region: PRK11715
331272014855	sensory histidine kinase CreC; Provisional; Region: PRK11100
331272014856	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272014857	dimerization interface [polypeptide binding]; other site
331272014858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272014859	dimer interface [polypeptide binding]; other site
331272014860	phosphorylation site [posttranslational modification]
331272014861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272014862	ATP binding site [chemical binding]; other site
331272014863	Mg2+ binding site [ion binding]; other site
331272014864	G-X-G motif; other site
331272014865	DNA-binding response regulator CreB; Provisional; Region: PRK11083
331272014866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272014867	active site
331272014868	phosphorylation site [posttranslational modification]
331272014869	intermolecular recognition site; other site
331272014870	dimerization interface [polypeptide binding]; other site
331272014871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272014872	DNA binding site [nucleotide binding]
331272014873	short chain dehydrogenase; Provisional; Region: PRK12828
331272014874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272014875	NAD(P) binding site [chemical binding]; other site
331272014876	active site
331272014877	Probable dihydrodipicolinate reductase; Region: PLN02775
331272014878	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
331272014879	classical (c) SDRs; Region: SDR_c; cd05233
331272014880	NAD(P) binding site [chemical binding]; other site
331272014881	active site
331272014882	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
331272014883	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272014884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014885	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272014886	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272014887	EamA-like transporter family; Region: EamA; pfam00892
331272014888	EamA-like transporter family; Region: EamA; pfam00892
331272014889	Predicted small secreted protein [Function unknown]; Region: COG5510
331272014890	aspartate carbamoyltransferase; Provisional; Region: PRK11891
331272014891	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
331272014892	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
331272014893	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
331272014894	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272014895	N-terminal plug; other site
331272014896	ligand-binding site [chemical binding]; other site
331272014897	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272014898	Sel1-like repeats; Region: SEL1; smart00671
331272014899	Sel1-like repeats; Region: SEL1; smart00671
331272014900	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
331272014901	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
331272014902	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
331272014903	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
331272014904	metal-binding site
331272014905	short chain dehydrogenase; Provisional; Region: PRK07060
331272014906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272014907	NAD(P) binding site [chemical binding]; other site
331272014908	active site
331272014909	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
331272014910	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
331272014911	N- and C-terminal domain interface [polypeptide binding]; other site
331272014912	putative active site [active]
331272014913	MgATP binding site [chemical binding]; other site
331272014914	catalytic site [active]
331272014915	metal binding site [ion binding]; metal-binding site
331272014916	putative xylulose binding site [chemical binding]; other site
331272014917	putative homodimer interface [polypeptide binding]; other site
331272014918	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272014919	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256
331272014920	putative NAD(P) binding site [chemical binding]; other site
331272014921	catalytic Zn binding site [ion binding]; other site
331272014922	structural Zn binding site [ion binding]; other site
331272014923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272014924	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272014925	TM-ABC transporter signature motif; other site
331272014926	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272014927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272014928	Walker A/P-loop; other site
331272014929	ATP binding site [chemical binding]; other site
331272014930	Q-loop/lid; other site
331272014931	ABC transporter signature motif; other site
331272014932	Walker B; other site
331272014933	D-loop; other site
331272014934	H-loop/switch region; other site
331272014935	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272014936	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
331272014937	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272014938	putative ligand binding site [chemical binding]; other site
331272014939	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272014940	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272014941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014942	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
331272014943	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272014944	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272014945	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
331272014946	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
331272014947	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272014948	dimer interface [polypeptide binding]; other site
331272014949	putative CheW interface [polypeptide binding]; other site
331272014950	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272014951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
331272014952	active site
331272014953	phosphorylation site [posttranslational modification]
331272014954	intermolecular recognition site; other site
331272014955	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272014956	DNA binding residues [nucleotide binding]
331272014957	dimerization interface [polypeptide binding]; other site
331272014958	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272014959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272014960	Walker A motif; other site
331272014961	ATP binding site [chemical binding]; other site
331272014962	Walker B motif; other site
331272014963	arginine finger; other site
331272014964	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
331272014965	DNA-binding interface [nucleotide binding]; DNA binding site
331272014966	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272014967	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272014968	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272014969	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272014970	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272014971	catalytic loop [active]
331272014972	iron binding site [ion binding]; other site
331272014973	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272014974	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272014975	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272014976	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272014977	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272014978	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272014979	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272014980	DNA binding site [nucleotide binding]
331272014981	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
331272014982	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
331272014983	type III secretion system protein YscR; Provisional; Region: PRK12797
331272014984	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272014985	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272014986	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272014987	catalytic residue [active]
331272014988	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
331272014989	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
331272014990	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
331272014991	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
331272014992	active site
331272014993	dimer interface [polypeptide binding]; other site
331272014994	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
331272014995	Ligand Binding Site [chemical binding]; other site
331272014996	Molecular Tunnel; other site
331272014997	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
331272014998	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
331272014999	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
331272015000	Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311
331272015001	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
331272015002	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
331272015003	Walker A motif/ATP binding site; other site
331272015004	Walker B motif; other site
331272015005	type III secretion system protein; Reviewed; Region: PRK06937
331272015006	Flagellar assembly protein FliH; Region: FliH; pfam02108
331272015007	YOP proteins translocation protein K (YscK); Region: YscK; pfam06578
331272015008	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
331272015009	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
331272015010	FHA domain; Region: FHA; pfam00498
331272015011	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
331272015012	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
331272015013	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272015014	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
331272015015	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331272015016	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
331272015017	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
331272015018	FHIPEP family; Region: FHIPEP; pfam00771
331272015019	Autoinducer binding domain; Region: Autoind_bind; pfam03472
331272015020	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
331272015021	DNA binding residues [nucleotide binding]
331272015022	Autoinducer binding domain; Region: Autoind_bind; pfam03472
331272015023	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272015024	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272015025	DNA binding residues [nucleotide binding]
331272015026	dimerization interface [polypeptide binding]; other site
331272015027	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
331272015028	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
331272015029	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
331272015030	Trehalase; Region: Trehalase; cl17346
331272015031	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
331272015032	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272015033	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272015034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015035	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272015036	putative substrate translocation pore; other site
331272015037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
331272015038	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
331272015039	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
331272015040	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
331272015041	NAD binding site [chemical binding]; other site
331272015042	homotetramer interface [polypeptide binding]; other site
331272015043	homodimer interface [polypeptide binding]; other site
331272015044	substrate binding site [chemical binding]; other site
331272015045	active site
331272015046	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
331272015047	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
331272015048	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
331272015049	propionate/acetate kinase; Provisional; Region: PRK12379
331272015050	phosphate acetyltransferase; Provisional; Region: PRK11890
331272015051	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
331272015052	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
331272015053	core domain interface [polypeptide binding]; other site
331272015054	delta subunit interface [polypeptide binding]; other site
331272015055	epsilon subunit interface [polypeptide binding]; other site
331272015056	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
331272015057	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
331272015058	gamma subunit interface [polypeptide binding]; other site
331272015059	epsilon subunit interface [polypeptide binding]; other site
331272015060	LBP interface [polypeptide binding]; other site
331272015061	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
331272015062	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272015063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272015064	Coenzyme A binding pocket [chemical binding]; other site
331272015065	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
331272015066	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
331272015067	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
331272015068	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
331272015069	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272015070	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272015071	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
331272015072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015073	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272015074	dimerization interface [polypeptide binding]; other site
331272015075	diaminopimelate decarboxylase; Provisional; Region: PRK11165
331272015076	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
331272015077	active site
331272015078	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272015079	substrate binding site [chemical binding]; other site
331272015080	catalytic residues [active]
331272015081	dimer interface [polypeptide binding]; other site
331272015082	EamA-like transporter family; Region: EamA; pfam00892
331272015083	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272015084	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272015085	DNA-binding site [nucleotide binding]; DNA binding site
331272015086	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272015087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272015088	homodimer interface [polypeptide binding]; other site
331272015089	catalytic residue [active]
331272015090	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
331272015091	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
331272015092	active site
331272015093	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
331272015094	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
331272015095	active site
331272015096	nucleotide binding site [chemical binding]; other site
331272015097	HIGH motif; other site
331272015098	KMSKS motif; other site
331272015099	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
331272015100	nudix motif; other site
331272015101	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
331272015102	hydrophobic ligand binding site; other site
331272015103	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
331272015104	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
331272015105	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
331272015106	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
331272015107	Short C-terminal domain; Region: SHOCT; pfam09851
331272015108	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
331272015109	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
331272015110	spermidine synthase; Provisional; Region: PRK03612
331272015111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272015112	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272015113	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
331272015114	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
331272015115	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
331272015116	active site
331272015117	metal binding site [ion binding]; metal-binding site
331272015118	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
331272015119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272015120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272015121	Coenzyme A binding pocket [chemical binding]; other site
331272015122	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272015123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272015125	dimerization interface [polypeptide binding]; other site
331272015126	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
331272015127	hypothetical protein; Provisional; Region: PRK07236
331272015128	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
331272015129	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
331272015130	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272015131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272015132	non-specific DNA binding site [nucleotide binding]; other site
331272015133	salt bridge; other site
331272015134	sequence-specific DNA binding site [nucleotide binding]; other site
331272015135	Cupin domain; Region: Cupin_2; pfam07883
331272015136	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272015137	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272015138	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
331272015139	Protein of unknown function, DUF488; Region: DUF488; pfam04343
331272015140	hypothetical protein; Provisional; Region: PRK10621
331272015141	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
331272015142	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
331272015143	Spore germination protein; Region: Spore_permease; cl17796
331272015144	NnrU protein; Region: NnrU; pfam07298
331272015145	TfoX N-terminal domain; Region: TfoX_N; pfam04993
331272015146	putative dehydrogenase; Provisional; Region: PRK10098
331272015147	hypothetical protein; Provisional; Region: PRK07907
331272015148	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
331272015149	metal binding site [ion binding]; metal-binding site
331272015150	putative dimer interface [polypeptide binding]; other site
331272015151	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
331272015152	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
331272015153	FMN binding site [chemical binding]; other site
331272015154	substrate binding site [chemical binding]; other site
331272015155	putative catalytic residue [active]
331272015156	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
331272015157	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272015158	conserved cys residue [active]
331272015159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015160	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015161	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
331272015162	active site residue [active]
331272015163	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
331272015164	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
331272015165	Cytochrome P450; Region: p450; cl12078
331272015166	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
331272015167	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272015168	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
331272015169	tetramer interface [polypeptide binding]; other site
331272015170	active site
331272015171	Mg2+/Mn2+ binding site [ion binding]; other site
331272015172	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
331272015173	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
331272015174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272015175	Coenzyme A binding pocket [chemical binding]; other site
331272015176	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
331272015177	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
331272015178	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
331272015179	putative active site [active]
331272015180	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
331272015181	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
331272015182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272015183	active site
331272015184	phosphorylation site [posttranslational modification]
331272015185	intermolecular recognition site; other site
331272015186	dimerization interface [polypeptide binding]; other site
331272015187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272015188	DNA binding site [nucleotide binding]
331272015189	sensor protein QseC; Provisional; Region: PRK10337
331272015190	HAMP domain; Region: HAMP; pfam00672
331272015191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272015192	dimer interface [polypeptide binding]; other site
331272015193	phosphorylation site [posttranslational modification]
331272015194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272015195	ATP binding site [chemical binding]; other site
331272015196	Mg2+ binding site [ion binding]; other site
331272015197	G-X-G motif; other site
331272015198	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272015199	MarR family; Region: MarR_2; pfam12802
331272015200	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
331272015201	Protein of unknown function (DUF805); Region: DUF805; cl01224
331272015202	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
331272015203	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272015204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015205	The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487
331272015206	putative dimerization interface [polypeptide binding]; other site
331272015207	putative substrate binding pocket [chemical binding]; other site
331272015208	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
331272015209	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
331272015210	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331272015211	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
331272015212	Autotransporter beta-domain; Region: Autotransporter; pfam03797
331272015213	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
331272015214	putative active site [active]
331272015215	rod shape-determining protein MreB; Provisional; Region: PRK13930
331272015216	MreB and similar proteins; Region: MreB_like; cd10225
331272015217	nucleotide binding site [chemical binding]; other site
331272015218	Mg binding site [ion binding]; other site
331272015219	putative protofilament interaction site [polypeptide binding]; other site
331272015220	RodZ interaction site [polypeptide binding]; other site
331272015221	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
331272015222	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
331272015223	active site
331272015224	nucleophile elbow; other site
331272015225	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
331272015226	Surface antigen; Region: Bac_surface_Ag; pfam01103
331272015227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272015228	dimer interface [polypeptide binding]; other site
331272015229	phosphorylation site [posttranslational modification]
331272015230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272015231	ATP binding site [chemical binding]; other site
331272015232	Mg2+ binding site [ion binding]; other site
331272015233	G-X-G motif; other site
331272015234	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
331272015235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272015236	active site
331272015237	phosphorylation site [posttranslational modification]
331272015238	intermolecular recognition site; other site
331272015239	dimerization interface [polypeptide binding]; other site
331272015240	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272015241	DNA binding site [nucleotide binding]
331272015242	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
331272015243	glutaminase; Provisional; Region: PRK00971
331272015244	short chain dehydrogenase; Provisional; Region: PRK05854
331272015245	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
331272015246	putative NAD(P) binding site [chemical binding]; other site
331272015247	active site
331272015248	Cytochrome c; Region: Cytochrom_C; cl11414
331272015249	Cytochrome c; Region: Cytochrom_C; pfam00034
331272015250	Cupin domain; Region: Cupin_2; cl17218
331272015251	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272015252	Isochorismatase family; Region: Isochorismatase; pfam00857
331272015253	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
331272015254	catalytic triad [active]
331272015255	conserved cis-peptide bond; other site
331272015256	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
331272015257	B1 nucleotide binding pocket [chemical binding]; other site
331272015258	B2 nucleotide binding pocket [chemical binding]; other site
331272015259	CAS motifs; other site
331272015260	active site
331272015261	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272015262	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272015263	non-specific DNA binding site [nucleotide binding]; other site
331272015264	salt bridge; other site
331272015265	sequence-specific DNA binding site [nucleotide binding]; other site
331272015266	HD domain; Region: HD_3; pfam13023
331272015267	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272015268	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272015269	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272015270	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331272015271	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331272015272	Walker A/P-loop; other site
331272015273	ATP binding site [chemical binding]; other site
331272015274	Q-loop/lid; other site
331272015275	ABC transporter signature motif; other site
331272015276	Walker B; other site
331272015277	D-loop; other site
331272015278	H-loop/switch region; other site
331272015279	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
331272015280	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331272015281	FtsX-like permease family; Region: FtsX; pfam02687
331272015282	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272015283	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272015284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015285	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272015286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015287	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
331272015288	putative effector binding pocket; other site
331272015289	putative dimerization interface [polypeptide binding]; other site
331272015290	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
331272015291	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272015292	substrate binding site [chemical binding]; other site
331272015293	oxyanion hole (OAH) forming residues; other site
331272015294	trimer interface [polypeptide binding]; other site
331272015295	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
331272015296	enoyl-CoA hydratase; Provisional; Region: PRK09076
331272015297	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272015298	substrate binding site [chemical binding]; other site
331272015299	oxyanion hole (OAH) forming residues; other site
331272015300	trimer interface [polypeptide binding]; other site
331272015301	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272015302	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
331272015303	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
331272015304	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
331272015305	tetrameric interface [polypeptide binding]; other site
331272015306	NAD binding site [chemical binding]; other site
331272015307	catalytic residues [active]
331272015308	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
331272015309	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
331272015310	active site
331272015311	acyl-activating enzyme (AAE) consensus motif; other site
331272015312	putative CoA binding site [chemical binding]; other site
331272015313	AMP binding site [chemical binding]; other site
331272015314	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272015315	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272015316	active site
331272015317	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272015318	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272015319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015320	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
331272015321	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
331272015322	active site residues [active]
331272015323	dimer interface [polypeptide binding]; other site
331272015324	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
331272015325	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
331272015326	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
331272015327	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
331272015328	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
331272015329	active site
331272015330	short chain dehydrogenase; Validated; Region: PRK05855
331272015331	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272015332	classical (c) SDRs; Region: SDR_c; cd05233
331272015333	NAD(P) binding site [chemical binding]; other site
331272015334	active site
331272015335	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
331272015336	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
331272015337	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
331272015338	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
331272015339	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
331272015340	TPR repeat; Region: TPR_11; pfam13414
331272015341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272015342	binding surface
331272015343	TPR motif; other site
331272015344	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
331272015345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272015346	binding surface
331272015347	TPR motif; other site
331272015348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
331272015349	TPR motif; other site
331272015350	binding surface
331272015351	TPR repeat; Region: TPR_11; pfam13414
331272015352	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
331272015353	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
331272015354	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
331272015355	GAF domain; Region: GAF; pfam01590
331272015356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272015357	Walker A motif; other site
331272015358	ATP binding site [chemical binding]; other site
331272015359	Walker B motif; other site
331272015360	arginine finger; other site
331272015361	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272015362	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272015363	catalytic loop [active]
331272015364	iron binding site [ion binding]; other site
331272015365	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
331272015366	putative hydrophobic ligand binding site [chemical binding]; other site
331272015367	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
331272015368	CopC domain; Region: CopC; pfam04234
331272015369	Protein of unknown function (DUF461); Region: DUF461; pfam04314
331272015370	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272015371	Leucine rich repeat; Region: LRR_8; pfam13855
331272015372	Protein kinase; unclassified specificity; Region: STYKc; smart00221
331272015373	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331272015374	active site
331272015375	ATP binding site [chemical binding]; other site
331272015376	substrate binding site [chemical binding]; other site
331272015377	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
331272015378	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015379	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
331272015380	putative dimerization interface [polypeptide binding]; other site
331272015381	putative substrate binding pocket [chemical binding]; other site
331272015382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015383	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272015384	putative substrate translocation pore; other site
331272015385	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
331272015386	muropeptide transporter; Validated; Region: ampG; cl17669
331272015387	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
331272015388	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
331272015389	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
331272015390	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272015391	N-terminal plug; other site
331272015392	ligand-binding site [chemical binding]; other site
331272015393	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331272015394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272015395	Walker A/P-loop; other site
331272015396	ATP binding site [chemical binding]; other site
331272015397	Q-loop/lid; other site
331272015398	ABC transporter signature motif; other site
331272015399	Walker B; other site
331272015400	D-loop; other site
331272015401	H-loop/switch region; other site
331272015402	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331272015403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272015404	Walker A/P-loop; other site
331272015405	ATP binding site [chemical binding]; other site
331272015406	Q-loop/lid; other site
331272015407	ABC transporter signature motif; other site
331272015408	Walker B; other site
331272015409	D-loop; other site
331272015410	H-loop/switch region; other site
331272015411	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
331272015412	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272015413	Condensation domain; Region: Condensation; pfam00668
331272015414	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272015415	Nonribosomal peptide synthase; Region: NRPS; pfam08415
331272015416	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
331272015417	acyl-activating enzyme (AAE) consensus motif; other site
331272015418	AMP binding site [chemical binding]; other site
331272015419	Methyltransferase domain; Region: Methyltransf_12; pfam08242
331272015420	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272015421	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272015422	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
331272015423	Condensation domain; Region: Condensation; pfam00668
331272015424	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
331272015425	Nonribosomal peptide synthase; Region: NRPS; pfam08415
331272015426	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
331272015427	acyl-activating enzyme (AAE) consensus motif; other site
331272015428	AMP binding site [chemical binding]; other site
331272015429	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272015430	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
331272015431	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272015432	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015433	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
331272015434	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
331272015435	acyl-activating enzyme (AAE) consensus motif; other site
331272015436	active site
331272015437	AMP binding site [chemical binding]; other site
331272015438	substrate binding site [chemical binding]; other site
331272015439	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
331272015440	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
331272015441	nucleophilic elbow; other site
331272015442	catalytic triad; other site
331272015443	isochorismate-pyruvate lyase; Reviewed; Region: PRK07075
331272015444	salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054
331272015445	chorismate binding enzyme; Region: Chorismate_bind; cl10555
331272015446	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
331272015447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015448	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
331272015449	putative dimerization interface [polypeptide binding]; other site
331272015450	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272015451	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
331272015452	inhibitor-cofactor binding pocket; inhibition site
331272015453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272015454	catalytic residue [active]
331272015455	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272015456	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
331272015457	NADP binding site [chemical binding]; other site
331272015458	active site
331272015459	steroid binding site; other site
331272015460	Cupin; Region: Cupin_6; pfam12852
331272015461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015462	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272015463	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015464	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272015465	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015466	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272015467	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015468	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
331272015469	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272015470	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
331272015471	dimer interface [polypeptide binding]; other site
331272015472	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272015473	EamA-like transporter family; Region: EamA; pfam00892
331272015474	EamA-like transporter family; Region: EamA; pfam00892
331272015475	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
331272015476	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272015477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015478	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272015479	dimerization interface [polypeptide binding]; other site
331272015480	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272015481	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272015482	Walker A/P-loop; other site
331272015483	ATP binding site [chemical binding]; other site
331272015484	Q-loop/lid; other site
331272015485	ABC transporter signature motif; other site
331272015486	Walker B; other site
331272015487	D-loop; other site
331272015488	H-loop/switch region; other site
331272015489	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
331272015490	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272015491	Walker A/P-loop; other site
331272015492	ATP binding site [chemical binding]; other site
331272015493	Q-loop/lid; other site
331272015494	ABC transporter signature motif; other site
331272015495	Walker B; other site
331272015496	D-loop; other site
331272015497	H-loop/switch region; other site
331272015498	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
331272015499	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
331272015500	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272015501	TM-ABC transporter signature motif; other site
331272015502	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272015503	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272015504	TM-ABC transporter signature motif; other site
331272015505	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272015506	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272015507	dimerization interface [polypeptide binding]; other site
331272015508	ligand binding site [chemical binding]; other site
331272015509	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
331272015510	PAAR motif; Region: PAAR_motif; pfam05488
331272015511	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
331272015512	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
331272015513	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
331272015514	RHS Repeat; Region: RHS_repeat; cl11982
331272015515	RHS Repeat; Region: RHS_repeat; cl11982
331272015516	RHS Repeat; Region: RHS_repeat; pfam05593
331272015517	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
331272015518	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
331272015519	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
331272015520	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
331272015521	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272015522	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272015523	putative outer membrane lipoprotein; Provisional; Region: PRK09967
331272015524	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272015525	ligand binding site [chemical binding]; other site
331272015526	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
331272015527	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272015528	metal binding site [ion binding]; metal-binding site
331272015529	active site
331272015530	I-site; other site
331272015531	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
331272015532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272015533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015534	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272015535	putative dimerization interface [polypeptide binding]; other site
331272015536	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
331272015537	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272015538	active site
331272015539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272015540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015541	D-galactonate transporter; Region: 2A0114; TIGR00893
331272015542	putative substrate translocation pore; other site
331272015543	amidase; Provisional; Region: PRK09201
331272015544	Amidase; Region: Amidase; cl11426
331272015545	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272015546	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272015547	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272015548	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
331272015549	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
331272015550	phosphate binding site [ion binding]; other site
331272015551	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272015552	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272015553	DNA-binding site [nucleotide binding]; DNA binding site
331272015554	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272015555	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272015556	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272015557	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
331272015558	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272015559	putative ligand binding site [chemical binding]; other site
331272015560	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272015561	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272015562	TM-ABC transporter signature motif; other site
331272015563	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272015564	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272015565	Walker A/P-loop; other site
331272015566	ATP binding site [chemical binding]; other site
331272015567	Q-loop/lid; other site
331272015568	ABC transporter signature motif; other site
331272015569	Walker B; other site
331272015570	D-loop; other site
331272015571	H-loop/switch region; other site
331272015572	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272015573	short chain dehydrogenase; Provisional; Region: PRK08628
331272015574	classical (c) SDRs; Region: SDR_c; cd05233
331272015575	NAD(P) binding site [chemical binding]; other site
331272015576	active site
331272015577	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
331272015578	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
331272015579	putative active site pocket [active]
331272015580	metal binding site [ion binding]; metal-binding site
331272015581	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272015582	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272015583	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272015584	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
331272015585	NAD binding site [chemical binding]; other site
331272015586	homotetramer interface [polypeptide binding]; other site
331272015587	homodimer interface [polypeptide binding]; other site
331272015588	active site
331272015589	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
331272015590	short chain dehydrogenase; Provisional; Region: PRK06197
331272015591	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
331272015592	putative NAD(P) binding site [chemical binding]; other site
331272015593	active site
331272015594	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272015595	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
331272015596	Protein of unknown function (DUF971); Region: DUF971; cl01414
331272015597	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
331272015598	substrate binding pocket [chemical binding]; other site
331272015599	active site
331272015600	iron coordination sites [ion binding]; other site
331272015601	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272015602	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
331272015603	active site
331272015604	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
331272015605	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272015606	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272015607	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
331272015608	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
331272015609	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
331272015610	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
331272015611	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015612	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272015613	dimerization interface [polypeptide binding]; other site
331272015614	substrate binding pocket [chemical binding]; other site
331272015615	Protein of unknown function, DUF606; Region: DUF606; pfam04657
331272015616	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272015617	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272015618	NAD(P) binding site [chemical binding]; other site
331272015619	catalytic residues [active]
331272015620	Cytochrome c; Region: Cytochrom_C; pfam00034
331272015621	Cytochrome c; Region: Cytochrom_C; pfam00034
331272015622	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
331272015623	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331272015624	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272015625	Methylamine utilisation protein MauE; Region: MauE; pfam07291
331272015626	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
331272015627	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
331272015628	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272015629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015630	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272015631	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
331272015632	conserved cys residue [active]
331272015633	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015634	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
331272015635	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
331272015636	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
331272015637	Zn binding site [ion binding]; other site
331272015638	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
331272015639	Peptidase family M28; Region: Peptidase_M28; pfam04389
331272015640	active site
331272015641	metal binding site [ion binding]; metal-binding site
331272015642	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
331272015643	H+ Antiporter protein; Region: 2A0121; TIGR00900
331272015644	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272015645	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272015646	trimer interface [polypeptide binding]; other site
331272015647	eyelet of channel; other site
331272015648	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
331272015649	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
331272015650	choline-sulfatase; Region: chol_sulfatase; TIGR03417
331272015651	Sulfatase; Region: Sulfatase; cl17466
331272015652	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
331272015653	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
331272015654	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015655	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272015656	dimerization interface [polypeptide binding]; other site
331272015657	substrate binding pocket [chemical binding]; other site
331272015658	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
331272015659	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
331272015660	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
331272015661	putative active site [active]
331272015662	putative substrate binding site [chemical binding]; other site
331272015663	putative cosubstrate binding site; other site
331272015664	catalytic site [active]
331272015665	Amino acid permease; Region: AA_permease_2; pfam13520
331272015666	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
331272015667	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
331272015668	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
331272015669	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
331272015670	FAD binding pocket [chemical binding]; other site
331272015671	FAD binding motif [chemical binding]; other site
331272015672	phosphate binding motif [ion binding]; other site
331272015673	beta-alpha-beta structure motif; other site
331272015674	NAD binding pocket [chemical binding]; other site
331272015675	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
331272015676	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272015677	catalytic loop [active]
331272015678	iron binding site [ion binding]; other site
331272015679	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272015680	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272015681	[2Fe-2S] cluster binding site [ion binding]; other site
331272015682	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
331272015683	putative alpha subunit interface [polypeptide binding]; other site
331272015684	putative active site [active]
331272015685	putative substrate binding site [chemical binding]; other site
331272015686	Fe binding site [ion binding]; other site
331272015687	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
331272015688	Electron transfer flavoprotein domain; Region: ETF; pfam01012
331272015689	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
331272015690	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
331272015691	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
331272015692	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
331272015693	4Fe-4S binding domain; Region: Fer4; cl02805
331272015694	Cysteine-rich domain; Region: CCG; pfam02754
331272015695	Cysteine-rich domain; Region: CCG; pfam02754
331272015696	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
331272015697	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
331272015698	putative active site [active]
331272015699	putative FMN binding site [chemical binding]; other site
331272015700	putative substrate binding site [chemical binding]; other site
331272015701	putative catalytic residue [active]
331272015702	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272015703	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
331272015704	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
331272015705	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
331272015706	active site
331272015707	dimer interface [polypeptide binding]; other site
331272015708	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
331272015709	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
331272015710	dimer interface [polypeptide binding]; other site
331272015711	active site
331272015712	glycine-pyridoxal phosphate binding site [chemical binding]; other site
331272015713	folate binding site [chemical binding]; other site
331272015714	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272015715	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
331272015716	conserved cys residue [active]
331272015717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015718	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
331272015719	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
331272015720	sugar binding site [chemical binding]; other site
331272015721	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272015722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272015723	DNA-binding site [nucleotide binding]; DNA binding site
331272015724	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272015725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272015726	homodimer interface [polypeptide binding]; other site
331272015727	catalytic residue [active]
331272015728	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
331272015729	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
331272015730	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
331272015731	NAD binding site [chemical binding]; other site
331272015732	catalytic Zn binding site [ion binding]; other site
331272015733	structural Zn binding site [ion binding]; other site
331272015734	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
331272015735	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272015736	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272015737	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
331272015738	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
331272015739	Ligand binding site; other site
331272015740	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272015741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015742	putative substrate translocation pore; other site
331272015743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015744	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
331272015745	active site
331272015746	TDP-binding site; other site
331272015747	acceptor substrate-binding pocket; other site
331272015748	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
331272015749	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272015750	transcriptional regulator BetI; Validated; Region: PRK00767
331272015751	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272015752	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
331272015753	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
331272015754	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
331272015755	tetrameric interface [polypeptide binding]; other site
331272015756	NAD binding site [chemical binding]; other site
331272015757	catalytic residues [active]
331272015758	choline dehydrogenase; Validated; Region: PRK02106
331272015759	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272015760	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
331272015761	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
331272015762	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
331272015763	Cupin domain; Region: Cupin_2; pfam07883
331272015764	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
331272015765	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
331272015766	Walker A/P-loop; other site
331272015767	ATP binding site [chemical binding]; other site
331272015768	Q-loop/lid; other site
331272015769	ABC transporter signature motif; other site
331272015770	Walker B; other site
331272015771	D-loop; other site
331272015772	H-loop/switch region; other site
331272015773	ABC-2 type transporter; Region: ABC2_membrane; cl17235
331272015774	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
331272015775	benzoate transport; Region: 2A0115; TIGR00895
331272015776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015777	putative substrate translocation pore; other site
331272015778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015779	PAS fold; Region: PAS_4; pfam08448
331272015780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272015781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272015782	dimer interface [polypeptide binding]; other site
331272015783	phosphorylation site [posttranslational modification]
331272015784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272015785	ATP binding site [chemical binding]; other site
331272015786	G-X-G motif; other site
331272015787	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
331272015788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272015789	active site
331272015790	phosphorylation site [posttranslational modification]
331272015791	intermolecular recognition site; other site
331272015792	dimerization interface [polypeptide binding]; other site
331272015793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
331272015794	Lipase (class 2); Region: Lipase_2; pfam01674
331272015795	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
331272015796	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272015797	catalytic site [active]
331272015798	Predicted esterase [General function prediction only]; Region: COG0627
331272015799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
331272015800	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
331272015801	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
331272015802	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272015803	FeS/SAM binding site; other site
331272015804	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
331272015805	coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859
331272015806	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
331272015807	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
331272015808	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
331272015809	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
331272015810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272015811	Walker A motif; other site
331272015812	ATP binding site [chemical binding]; other site
331272015813	Walker B motif; other site
331272015814	arginine finger; other site
331272015815	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272015816	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
331272015817	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
331272015818	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272015819	N-terminal plug; other site
331272015820	ligand-binding site [chemical binding]; other site
331272015821	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
331272015822	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
331272015823	dimer interface [polypeptide binding]; other site
331272015824	Trp docking motif [polypeptide binding]; other site
331272015825	active site
331272015826	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331272015827	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272015828	membrane-bound complex binding site; other site
331272015829	hinge residues; other site
331272015830	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
331272015831	High potential iron-sulfur protein; Region: HIPIP; pfam01355
331272015832	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
331272015833	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
331272015834	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272015835	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
331272015836	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272015837	DNA binding residues [nucleotide binding]
331272015838	acetyl-CoA synthetase; Provisional; Region: PRK00174
331272015839	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
331272015840	active site
331272015841	CoA binding site [chemical binding]; other site
331272015842	acyl-activating enzyme (AAE) consensus motif; other site
331272015843	AMP binding site [chemical binding]; other site
331272015844	acetate binding site [chemical binding]; other site
331272015845	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272015846	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272015847	trimer interface [polypeptide binding]; other site
331272015848	eyelet of channel; other site
331272015849	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272015850	dimer interface [polypeptide binding]; other site
331272015851	putative CheW interface [polypeptide binding]; other site
331272015852	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
331272015853	Transglycosylase; Region: Transgly; pfam00912
331272015854	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272015855	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
331272015856	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
331272015857	MG2 domain; Region: A2M_N; pfam01835
331272015858	Alpha-2-macroglobulin family; Region: A2M; pfam00207
331272015859	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
331272015860	surface patch; other site
331272015861	thioester region; other site
331272015862	specificity defining residues; other site
331272015863	Probable transposase; Region: OrfB_IS605; pfam01385
331272015864	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272015865	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272015866	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
331272015867	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331272015868	FtsX-like permease family; Region: FtsX; pfam02687
331272015869	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
331272015870	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272015871	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
331272015872	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
331272015873	nudix motif; other site
331272015874	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
331272015875	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
331272015876	putative ligand binding site [chemical binding]; other site
331272015877	NAD binding site [chemical binding]; other site
331272015878	catalytic site [active]
331272015879	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
331272015880	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
331272015881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272015882	ABC-ATPase subunit interface; other site
331272015883	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
331272015884	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
331272015885	Walker A/P-loop; other site
331272015886	ATP binding site [chemical binding]; other site
331272015887	Q-loop/lid; other site
331272015888	ABC transporter signature motif; other site
331272015889	Walker B; other site
331272015890	D-loop; other site
331272015891	H-loop/switch region; other site
331272015892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272015893	ABC-ATPase subunit interface; other site
331272015894	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
331272015895	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272015896	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272015897	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272015898	catalytic residue [active]
331272015899	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
331272015900	active site
331272015901	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
331272015902	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
331272015903	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
331272015904	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272015905	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
331272015906	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
331272015907	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
331272015908	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
331272015909	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272015910	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
331272015911	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
331272015912	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
331272015913	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272015914	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
331272015915	conserved cys residue [active]
331272015916	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015917	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272015918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272015919	DNA-binding site [nucleotide binding]; DNA binding site
331272015920	FCD domain; Region: FCD; pfam07729
331272015921	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272015922	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272015923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
331272015924	putative aldolase; Validated; Region: PRK08130
331272015925	intersubunit interface [polypeptide binding]; other site
331272015926	active site
331272015927	Zn2+ binding site [ion binding]; other site
331272015928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015929	D-galactonate transporter; Region: 2A0114; TIGR00893
331272015930	putative substrate translocation pore; other site
331272015931	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
331272015932	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272015933	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
331272015934	putative NAD(P) binding site [chemical binding]; other site
331272015935	active site
331272015936	putative substrate binding site [chemical binding]; other site
331272015937	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272015938	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272015939	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
331272015940	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272015941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272015942	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272015943	dimerization interface [polypeptide binding]; other site
331272015944	Predicted membrane protein [Function unknown]; Region: COG4125
331272015945	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272015946	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272015947	Predicted membrane protein [Function unknown]; Region: COG2860
331272015948	UPF0126 domain; Region: UPF0126; pfam03458
331272015949	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
331272015950	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
331272015951	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272015952	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
331272015953	conserved cys residue [active]
331272015954	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
331272015955	metal binding site [ion binding]; metal-binding site
331272015956	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272015957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272015958	dimer interface [polypeptide binding]; other site
331272015959	conserved gate region; other site
331272015960	putative PBP binding loops; other site
331272015961	ABC-ATPase subunit interface; other site
331272015962	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
331272015963	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
331272015964	Walker A/P-loop; other site
331272015965	ATP binding site [chemical binding]; other site
331272015966	Q-loop/lid; other site
331272015967	ABC transporter signature motif; other site
331272015968	Walker B; other site
331272015969	D-loop; other site
331272015970	H-loop/switch region; other site
331272015971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
331272015972	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
331272015973	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
331272015974	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
331272015975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272015976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272015977	Coenzyme A binding pocket [chemical binding]; other site
331272015978	NIPSNAP; Region: NIPSNAP; pfam07978
331272015979	Predicted flavoprotein [General function prediction only]; Region: COG0431
331272015980	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272015981	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
331272015982	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
331272015983	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272015984	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272015985	non-specific DNA binding site [nucleotide binding]; other site
331272015986	salt bridge; other site
331272015987	sequence-specific DNA binding site [nucleotide binding]; other site
331272015988	Domain of unknown function (DUF955); Region: DUF955; cl01076
331272015989	HEPN domain; Region: HEPN; cl00824
331272015990	Family description; Region: UvrD_C_2; pfam13538
331272015991	mercuric reductase; Validated; Region: PRK06370
331272015992	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272015993	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272015994	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
331272015995	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272015996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272015997	putative substrate translocation pore; other site
331272015998	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
331272015999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272016000	active site
331272016001	phosphorylation site [posttranslational modification]
331272016002	intermolecular recognition site; other site
331272016003	dimerization interface [polypeptide binding]; other site
331272016004	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272016005	DNA binding residues [nucleotide binding]
331272016006	dimerization interface [polypeptide binding]; other site
331272016007	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272016008	PAS domain; Region: PAS_9; pfam13426
331272016009	putative active site [active]
331272016010	heme pocket [chemical binding]; other site
331272016011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272016012	PAS fold; Region: PAS_3; pfam08447
331272016013	putative active site [active]
331272016014	heme pocket [chemical binding]; other site
331272016015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272016016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272016017	dimer interface [polypeptide binding]; other site
331272016018	phosphorylation site [posttranslational modification]
331272016019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272016020	ATP binding site [chemical binding]; other site
331272016021	Mg2+ binding site [ion binding]; other site
331272016022	G-X-G motif; other site
331272016023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272016024	active site
331272016025	phosphorylation site [posttranslational modification]
331272016026	intermolecular recognition site; other site
331272016027	dimerization interface [polypeptide binding]; other site
331272016028	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016029	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016030	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272016031	dimerization interface [polypeptide binding]; other site
331272016032	BON domain; Region: BON; pfam04972
331272016033	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272016034	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
331272016035	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272016036	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272016037	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272016038	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272016039	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272016040	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272016041	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272016042	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272016043	catalytic loop [active]
331272016044	iron binding site [ion binding]; other site
331272016045	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272016046	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272016047	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272016048	ligand binding site [chemical binding]; other site
331272016049	flexible hinge region; other site
331272016050	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
331272016051	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
331272016052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272016053	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016055	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272016056	dimerization interface [polypeptide binding]; other site
331272016057	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272016058	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272016059	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272016060	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
331272016061	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
331272016062	dimer interface [polypeptide binding]; other site
331272016063	active site
331272016064	heme binding site [chemical binding]; other site
331272016065	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
331272016066	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
331272016067	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272016068	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272016069	conserved cys residue [active]
331272016070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016071	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272016072	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016073	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272016074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016075	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272016076	putative substrate translocation pore; other site
331272016077	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
331272016078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272016079	NAD(P) binding site [chemical binding]; other site
331272016080	active site
331272016081	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272016082	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272016083	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272016084	conserved cys residue [active]
331272016085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016086	FRG domain; Region: FRG; pfam08867
331272016087	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272016088	active site
331272016089	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
331272016090	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
331272016091	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
331272016092	H-NS histone family; Region: Histone_HNS; pfam00816
331272016093	Seripauperin and TIP1 family; Region: SRP1_TIP1; pfam00660
331272016094	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272016095	TniQ; Region: TniQ; pfam06527
331272016096	TniQ; Region: TniQ; pfam06527
331272016097	Bacterial TniB protein; Region: TniB; pfam05621
331272016098	Integrase core domain; Region: rve; pfam00665
331272016099	head completion protein; Provisional; Region: 4; PHA02552
331272016100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272016101	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
331272016102	Walker A motif; other site
331272016103	ATP binding site [chemical binding]; other site
331272016104	Walker B motif; other site
331272016105	arginine finger; other site
331272016106	Helix-turn-helix domain; Region: HTH_36; pfam13730
331272016107	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
331272016108	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272016109	trimer interface [polypeptide binding]; other site
331272016110	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272016111	YadA-like C-terminal region; Region: YadA; pfam03895
331272016112	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272016113	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272016114	ligand binding site [chemical binding]; other site
331272016115	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
331272016116	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
331272016117	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
331272016118	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
331272016119	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
331272016120	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272016121	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
331272016122	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
331272016123	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
331272016124	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272016125	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272016126	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272016127	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
331272016128	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331272016129	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331272016130	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
331272016131	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
331272016132	carboxyltransferase (CT) interaction site; other site
331272016133	biotinylation site [posttranslational modification]; other site
331272016134	enoyl-CoA hydratase; Provisional; Region: PRK05995
331272016135	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272016136	substrate binding site [chemical binding]; other site
331272016137	oxyanion hole (OAH) forming residues; other site
331272016138	trimer interface [polypeptide binding]; other site
331272016139	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
331272016140	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
331272016141	isovaleryl-CoA dehydrogenase; Region: PLN02519
331272016142	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
331272016143	substrate binding site [chemical binding]; other site
331272016144	FAD binding site [chemical binding]; other site
331272016145	catalytic base [active]
331272016146	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016147	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016148	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
331272016149	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272016150	MarR family; Region: MarR; pfam01047
331272016151	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272016152	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
331272016153	iron-sulfur cluster [ion binding]; other site
331272016154	[2Fe-2S] cluster binding site [ion binding]; other site
331272016155	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
331272016156	alpha subunit interface [polypeptide binding]; other site
331272016157	active site
331272016158	substrate binding site [chemical binding]; other site
331272016159	Fe binding site [ion binding]; other site
331272016160	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
331272016161	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
331272016162	FMN-binding pocket [chemical binding]; other site
331272016163	flavin binding motif; other site
331272016164	phosphate binding motif [ion binding]; other site
331272016165	beta-alpha-beta structure motif; other site
331272016166	NAD binding pocket [chemical binding]; other site
331272016167	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272016168	catalytic loop [active]
331272016169	iron binding site [ion binding]; other site
331272016170	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272016171	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272016172	N-terminal plug; other site
331272016173	ligand-binding site [chemical binding]; other site
331272016174	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
331272016175	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272016176	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272016177	eyelet of channel; other site
331272016178	trimer interface [polypeptide binding]; other site
331272016179	Probable transposase; Region: OrfB_IS605; pfam01385
331272016180	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272016181	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272016182	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272016183	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272016184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272016185	Coenzyme A binding pocket [chemical binding]; other site
331272016186	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
331272016187	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
331272016188	active site
331272016189	metal binding site [ion binding]; metal-binding site
331272016190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272016191	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272016192	catalytic site [active]
331272016193	TAP-like protein; Region: Abhydrolase_4; pfam08386
331272016194	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272016195	dimerization interface [polypeptide binding]; other site
331272016196	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272016197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272016198	ATP binding site [chemical binding]; other site
331272016199	Mg2+ binding site [ion binding]; other site
331272016200	G-X-G motif; other site
331272016201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272016202	active site
331272016203	phosphorylation site [posttranslational modification]
331272016204	intermolecular recognition site; other site
331272016205	dimerization interface [polypeptide binding]; other site
331272016206	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272016207	DNA binding site [nucleotide binding]
331272016208	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
331272016209	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272016210	catalytic residues [active]
331272016211	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
331272016212	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272016213	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272016214	DNA-binding site [nucleotide binding]; DNA binding site
331272016215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272016216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272016217	homodimer interface [polypeptide binding]; other site
331272016218	catalytic residue [active]
331272016219	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
331272016220	Transglycosylase; Region: Transgly; pfam00912
331272016221	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272016222	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
331272016223	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272016224	active site
331272016225	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
331272016226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016228	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272016229	dimerization interface [polypeptide binding]; other site
331272016230	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
331272016231	active site
331272016232	tetramer interface [polypeptide binding]; other site
331272016233	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272016234	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272016235	trimer interface [polypeptide binding]; other site
331272016236	eyelet of channel; other site
331272016237	benzoate transport; Region: 2A0115; TIGR00895
331272016238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016240	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
331272016241	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
331272016242	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272016243	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
331272016244	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
331272016245	putative active site [active]
331272016246	putative NTP binding site [chemical binding]; other site
331272016247	putative nucleic acid binding site [nucleotide binding]; other site
331272016248	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
331272016249	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
331272016250	aldehyde dehydrogenase family 7 member; Region: PLN02315
331272016251	tetrameric interface [polypeptide binding]; other site
331272016252	NAD binding site [chemical binding]; other site
331272016253	catalytic residues [active]
331272016254	lysine transporter; Provisional; Region: PRK10836
331272016255	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272016256	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272016257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016259	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272016260	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
331272016261	putative active site [active]
331272016262	catalytic site [active]
331272016263	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
331272016264	putative active site [active]
331272016265	catalytic site [active]
331272016266	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
331272016267	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
331272016268	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
331272016269	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
331272016270	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
331272016271	homodimer interface [polypeptide binding]; other site
331272016272	NAD binding pocket [chemical binding]; other site
331272016273	ATP binding pocket [chemical binding]; other site
331272016274	Mg binding site [ion binding]; other site
331272016275	active-site loop [active]
331272016276	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
331272016277	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
331272016278	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
331272016279	peptidase domain interface [polypeptide binding]; other site
331272016280	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
331272016281	active site
331272016282	catalytic triad [active]
331272016283	calcium binding site [ion binding]; other site
331272016284	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272016285	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272016286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272016287	putative DNA binding site [nucleotide binding]; other site
331272016288	putative Zn2+ binding site [ion binding]; other site
331272016289	AsnC family; Region: AsnC_trans_reg; pfam01037
331272016290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016292	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272016293	dimerization interface [polypeptide binding]; other site
331272016294	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
331272016295	agmatinase; Region: agmatinase; TIGR01230
331272016296	oligomer interface [polypeptide binding]; other site
331272016297	putative active site [active]
331272016298	Mn binding site [ion binding]; other site
331272016299	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272016300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016301	putative substrate translocation pore; other site
331272016302	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
331272016303	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
331272016304	THF binding site; other site
331272016305	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
331272016306	substrate binding site [chemical binding]; other site
331272016307	THF binding site; other site
331272016308	zinc-binding site [ion binding]; other site
331272016309	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
331272016310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016311	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
331272016312	putative dimerization interface [polypeptide binding]; other site
331272016313	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
331272016314	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
331272016315	catalytic core [active]
331272016316	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
331272016317	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
331272016318	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
331272016319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
331272016320	putative transporter; Provisional; Region: PRK10504
331272016321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016322	putative substrate translocation pore; other site
331272016323	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
331272016324	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
331272016325	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
331272016326	NAD(P) binding site [chemical binding]; other site
331272016327	catalytic residues [active]
331272016328	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
331272016329	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
331272016330	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272016331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272016332	conserved gate region; other site
331272016333	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
331272016334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272016335	dimer interface [polypeptide binding]; other site
331272016336	conserved gate region; other site
331272016337	putative PBP binding loops; other site
331272016338	ABC-ATPase subunit interface; other site
331272016339	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
331272016340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272016341	Walker A/P-loop; other site
331272016342	ATP binding site [chemical binding]; other site
331272016343	Q-loop/lid; other site
331272016344	ABC transporter signature motif; other site
331272016345	Walker B; other site
331272016346	D-loop; other site
331272016347	H-loop/switch region; other site
331272016348	TOBE domain; Region: TOBE_2; pfam08402
331272016349	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272016350	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
331272016351	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
331272016352	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272016353	catalytic residue [active]
331272016354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016355	D-galactonate transporter; Region: 2A0114; TIGR00893
331272016356	putative substrate translocation pore; other site
331272016357	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
331272016358	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
331272016359	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
331272016360	shikimate binding site; other site
331272016361	NAD(P) binding site [chemical binding]; other site
331272016362	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
331272016363	Dehydroquinase class II; Region: DHquinase_II; pfam01220
331272016364	active site
331272016365	trimer interface [polypeptide binding]; other site
331272016366	dimer interface [polypeptide binding]; other site
331272016367	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
331272016368	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
331272016369	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
331272016370	dimer interface [polypeptide binding]; other site
331272016371	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
331272016372	active site
331272016373	Fe binding site [ion binding]; other site
331272016374	SPRY-associated domain; Region: PRY; cl02686
331272016375	PAS fold; Region: PAS_4; pfam08448
331272016376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272016377	putative active site [active]
331272016378	heme pocket [chemical binding]; other site
331272016379	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272016380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016382	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272016383	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272016384	dimerization interface [polypeptide binding]; other site
331272016385	ligand binding site [chemical binding]; other site
331272016386	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272016387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016388	putative substrate translocation pore; other site
331272016389	Predicted membrane protein [Function unknown]; Region: COG2259
331272016390	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
331272016391	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272016392	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
331272016393	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
331272016394	homodimer interface [polypeptide binding]; other site
331272016395	substrate-cofactor binding pocket; other site
331272016396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272016397	catalytic residue [active]
331272016398	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272016399	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272016400	dimerization interface [polypeptide binding]; other site
331272016401	ligand binding site [chemical binding]; other site
331272016402	galactarate dehydratase; Region: galactar-dH20; TIGR03248
331272016403	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
331272016404	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
331272016405	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272016406	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
331272016407	putative active site [active]
331272016408	catalytic residue [active]
331272016409	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
331272016410	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
331272016411	putative active site [active]
331272016412	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
331272016413	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
331272016414	dimer interface [polypeptide binding]; other site
331272016415	NADP binding site [chemical binding]; other site
331272016416	catalytic residues [active]
331272016417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016418	D-galactonate transporter; Region: 2A0114; TIGR00893
331272016419	putative substrate translocation pore; other site
331272016420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016421	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
331272016422	Peptidase family M50; Region: Peptidase_M50; pfam02163
331272016423	active site
331272016424	putative substrate binding region [chemical binding]; other site
331272016425	Protein of unknown function (DUF2167); Region: DUF2167; pfam09935
331272016426	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272016427	non-specific DNA binding site [nucleotide binding]; other site
331272016428	salt bridge; other site
331272016429	sequence-specific DNA binding site [nucleotide binding]; other site
331272016430	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272016431	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272016432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272016433	putative DNA binding site [nucleotide binding]; other site
331272016434	putative Zn2+ binding site [ion binding]; other site
331272016435	AsnC family; Region: AsnC_trans_reg; pfam01037
331272016436	dihydroorotase; Validated; Region: PRK09060
331272016437	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272016438	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
331272016439	active site
331272016440	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
331272016441	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
331272016442	trimer interface [polypeptide binding]; other site
331272016443	active site
331272016444	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
331272016445	putative GTP cyclohydrolase; Provisional; Region: PRK13674
331272016446	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
331272016447	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
331272016448	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
331272016449	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
331272016450	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
331272016451	Flavin binding site [chemical binding]; other site
331272016452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272016453	dimer interface [polypeptide binding]; other site
331272016454	conserved gate region; other site
331272016455	ABC-ATPase subunit interface; other site
331272016456	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
331272016457	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
331272016458	Walker A/P-loop; other site
331272016459	ATP binding site [chemical binding]; other site
331272016460	Q-loop/lid; other site
331272016461	ABC transporter signature motif; other site
331272016462	Walker B; other site
331272016463	D-loop; other site
331272016464	H-loop/switch region; other site
331272016465	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
331272016466	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
331272016467	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
331272016468	active site
331272016469	non-prolyl cis peptide bond; other site
331272016470	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
331272016471	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
331272016472	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
331272016473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272016474	dimer interface [polypeptide binding]; other site
331272016475	phosphorylation site [posttranslational modification]
331272016476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272016477	ATP binding site [chemical binding]; other site
331272016478	Mg2+ binding site [ion binding]; other site
331272016479	G-X-G motif; other site
331272016480	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272016481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272016482	active site
331272016483	phosphorylation site [posttranslational modification]
331272016484	intermolecular recognition site; other site
331272016485	dimerization interface [polypeptide binding]; other site
331272016486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272016487	Walker A motif; other site
331272016488	ATP binding site [chemical binding]; other site
331272016489	Walker B motif; other site
331272016490	arginine finger; other site
331272016491	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272016492	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
331272016493	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
331272016494	MarR family; Region: MarR_2; cl17246
331272016495	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272016496	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
331272016497	catalytic site [active]
331272016498	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272016499	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
331272016500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016502	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272016503	dimerization interface [polypeptide binding]; other site
331272016504	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272016505	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
331272016506	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272016507	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272016508	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272016509	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272016510	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272016511	substrate binding pocket [chemical binding]; other site
331272016512	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016514	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272016515	putative effector binding pocket; other site
331272016516	putative dimerization interface [polypeptide binding]; other site
331272016517	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272016518	Purine nucleoside permease (NUP); Region: NUP; pfam06516
331272016519	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272016520	selenophosphate synthetase; Provisional; Region: PRK00943
331272016521	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
331272016522	dimerization interface [polypeptide binding]; other site
331272016523	putative ATP binding site [chemical binding]; other site
331272016524	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
331272016525	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272016526	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272016527	DNA-binding site [nucleotide binding]; DNA binding site
331272016528	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272016529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272016530	homodimer interface [polypeptide binding]; other site
331272016531	catalytic residue [active]
331272016532	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
331272016533	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272016534	inhibitor-cofactor binding pocket; inhibition site
331272016535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272016536	catalytic residue [active]
331272016537	succinic semialdehyde dehydrogenase; Region: PLN02278
331272016538	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331272016539	tetramerization interface [polypeptide binding]; other site
331272016540	NAD(P) binding site [chemical binding]; other site
331272016541	catalytic residues [active]
331272016542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272016543	PAS domain; Region: PAS_9; pfam13426
331272016544	putative active site [active]
331272016545	heme pocket [chemical binding]; other site
331272016546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
331272016547	dimerization interface [polypeptide binding]; other site
331272016548	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272016549	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272016550	dimer interface [polypeptide binding]; other site
331272016551	putative CheW interface [polypeptide binding]; other site
331272016552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272016553	PAS domain; Region: PAS_9; pfam13426
331272016554	putative active site [active]
331272016555	heme pocket [chemical binding]; other site
331272016556	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
331272016557	dimerization interface [polypeptide binding]; other site
331272016558	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272016559	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272016560	dimer interface [polypeptide binding]; other site
331272016561	putative CheW interface [polypeptide binding]; other site
331272016562	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272016563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272016564	S-adenosylmethionine binding site [chemical binding]; other site
331272016565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272016566	Coenzyme A binding pocket [chemical binding]; other site
331272016567	Uncharacterized conserved protein [Function unknown]; Region: COG1683
331272016568	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
331272016569	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272016570	dimer interface [polypeptide binding]; other site
331272016571	active site
331272016572	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
331272016573	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272016574	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272016575	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
331272016576	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
331272016577	active site
331272016578	Zn binding site [ion binding]; other site
331272016579	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
331272016580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272016581	substrate binding pocket [chemical binding]; other site
331272016582	membrane-bound complex binding site; other site
331272016583	hinge residues; other site
331272016584	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
331272016585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016586	LysR substrate binding domain; Region: LysR_substrate; pfam03466
331272016587	dimerization interface [polypeptide binding]; other site
331272016588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016589	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272016590	putative substrate translocation pore; other site
331272016591	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272016592	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272016593	metal binding site [ion binding]; metal-binding site
331272016594	putative dimer interface [polypeptide binding]; other site
331272016595	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331272016596	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272016597	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272016598	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272016599	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272016600	FMN binding site [chemical binding]; other site
331272016601	active site
331272016602	substrate binding site [chemical binding]; other site
331272016603	catalytic residue [active]
331272016604	classical (c) SDRs; Region: SDR_c; cd05233
331272016605	NAD(P) binding site [chemical binding]; other site
331272016606	active site
331272016607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016609	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272016610	putative effector binding pocket; other site
331272016611	dimerization interface [polypeptide binding]; other site
331272016612	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272016613	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272016614	Cytochrome c; Region: Cytochrom_C; pfam00034
331272016615	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272016616	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272016617	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272016618	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272016619	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272016620	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272016621	catalytic loop [active]
331272016622	iron binding site [ion binding]; other site
331272016623	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272016624	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
331272016625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016626	putative substrate translocation pore; other site
331272016627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016629	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272016630	putative effector binding pocket; other site
331272016631	putative dimerization interface [polypeptide binding]; other site
331272016632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016634	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272016635	putative effector binding pocket; other site
331272016636	putative dimerization interface [polypeptide binding]; other site
331272016637	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272016638	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
331272016639	putative NAD(P) binding site [chemical binding]; other site
331272016640	homodimer interface [polypeptide binding]; other site
331272016641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016643	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
331272016644	putative effector binding pocket; other site
331272016645	putative dimerization interface [polypeptide binding]; other site
331272016646	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272016647	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272016648	active site
331272016649	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272016650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016651	putative substrate translocation pore; other site
331272016652	H+ Antiporter protein; Region: 2A0121; TIGR00900
331272016653	benzoate transport; Region: 2A0115; TIGR00895
331272016654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016655	putative substrate translocation pore; other site
331272016656	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272016657	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272016658	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272016659	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272016660	trimer interface [polypeptide binding]; other site
331272016661	eyelet of channel; other site
331272016662	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272016663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016664	putative substrate translocation pore; other site
331272016665	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
331272016666	Strictosidine synthase; Region: Str_synth; pfam03088
331272016667	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
331272016668	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
331272016669	ligand binding site [chemical binding]; other site
331272016670	NAD binding site [chemical binding]; other site
331272016671	dimerization interface [polypeptide binding]; other site
331272016672	catalytic site [active]
331272016673	hypothetical protein; Validated; Region: PRK06201
331272016674	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
331272016675	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272016676	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272016677	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016679	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
331272016680	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
331272016681	NADP binding site [chemical binding]; other site
331272016682	dimer interface [polypeptide binding]; other site
331272016683	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
331272016684	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
331272016685	Beta-lactamase; Region: Beta-lactamase; pfam00144
331272016686	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331272016687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016689	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272016690	dimerization interface [polypeptide binding]; other site
331272016691	short chain dehydrogenase; Provisional; Region: PRK06180
331272016692	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272016693	NADP binding site [chemical binding]; other site
331272016694	active site
331272016695	steroid binding site; other site
331272016696	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016697	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016698	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
331272016699	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
331272016700	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
331272016701	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016702	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016703	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272016704	dimerization interface [polypeptide binding]; other site
331272016705	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272016706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016707	putative substrate translocation pore; other site
331272016708	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
331272016709	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272016710	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
331272016711	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272016712	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272016713	active site
331272016714	catalytic tetrad [active]
331272016715	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272016716	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272016717	FMN binding site [chemical binding]; other site
331272016718	active site
331272016719	substrate binding site [chemical binding]; other site
331272016720	catalytic residue [active]
331272016721	Putative cyclase; Region: Cyclase; pfam04199
331272016722	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
331272016723	Methyltransferase domain; Region: Methyltransf_24; pfam13578
331272016724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016725	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016726	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
331272016727	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
331272016728	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
331272016729	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272016730	conserved cys residue [active]
331272016731	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272016733	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
331272016734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016735	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272016736	dimerization interface [polypeptide binding]; other site
331272016737	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272016738	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272016739	substrate binding pocket [chemical binding]; other site
331272016740	membrane-bound complex binding site; other site
331272016741	hinge residues; other site
331272016742	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
331272016743	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
331272016744	active site
331272016745	Zn binding site [ion binding]; other site
331272016746	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
331272016747	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
331272016748	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272016749	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272016750	trimer interface [polypeptide binding]; other site
331272016751	eyelet of channel; other site
331272016752	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
331272016753	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
331272016754	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272016755	N-terminal plug; other site
331272016756	ligand-binding site [chemical binding]; other site
331272016757	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
331272016758	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
331272016759	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
331272016760	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
331272016761	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
331272016762	intersubunit interface [polypeptide binding]; other site
331272016763	ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609
331272016764	putative PBP binding regions; other site
331272016765	ABC-ATPase subunit  interface; other site
331272016766	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547
331272016767	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
331272016768	Walker A/P-loop; other site
331272016769	ATP binding site [chemical binding]; other site
331272016770	Q-loop/lid; other site
331272016771	ABC transporter signature motif; other site
331272016772	Walker B; other site
331272016773	D-loop; other site
331272016774	H-loop/switch region; other site
331272016775	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331272016776	active site
331272016777	Predicted membrane protein [Function unknown]; Region: COG2860
331272016778	UPF0126 domain; Region: UPF0126; pfam03458
331272016779	UPF0126 domain; Region: UPF0126; pfam03458
331272016780	Transglycosylase; Region: Transgly; pfam00912
331272016781	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
331272016782	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
331272016783	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
331272016784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016786	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
331272016787	putative substrate binding pocket [chemical binding]; other site
331272016788	putative dimerization interface [polypeptide binding]; other site
331272016789	hypothetical protein; Provisional; Region: PRK11171
331272016790	Cupin domain; Region: Cupin_2; pfam07883
331272016791	Cupin domain; Region: Cupin_2; pfam07883
331272016792	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
331272016793	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
331272016794	HIT family signature motif; other site
331272016795	catalytic residue [active]
331272016796	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331272016797	Beta-lactamase; Region: Beta-lactamase; pfam00144
331272016798	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272016799	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
331272016800	putative C-terminal domain interface [polypeptide binding]; other site
331272016801	putative GSH binding site (G-site) [chemical binding]; other site
331272016802	putative dimer interface [polypeptide binding]; other site
331272016803	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
331272016804	putative N-terminal domain interface [polypeptide binding]; other site
331272016805	putative dimer interface [polypeptide binding]; other site
331272016806	putative substrate binding pocket (H-site) [chemical binding]; other site
331272016807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272016808	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
331272016809	NAD(P) binding site [chemical binding]; other site
331272016810	active site
331272016811	Protein of unknown function, DUF393; Region: DUF393; pfam04134
331272016812	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
331272016813	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
331272016814	NADH(P)-binding; Region: NAD_binding_10; pfam13460
331272016815	putative NAD(P) binding site [chemical binding]; other site
331272016816	active site
331272016817	DoxX-like family; Region: DoxX_3; pfam13781
331272016818	Predicted transcriptional regulators [Transcription]; Region: COG1510
331272016819	MarR family; Region: MarR_2; pfam12802
331272016820	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
331272016821	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
331272016822	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
331272016823	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
331272016824	short chain dehydrogenase; Validated; Region: PRK08264
331272016825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272016826	NAD(P) binding site [chemical binding]; other site
331272016827	active site
331272016828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272016829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272016830	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
331272016831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272016832	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272016833	dimerization interface [polypeptide binding]; other site
331272016834	putative DNA binding site [nucleotide binding]; other site
331272016835	putative Zn2+ binding site [ion binding]; other site
331272016836	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
331272016837	putative hydrophobic ligand binding site [chemical binding]; other site
331272016838	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
331272016839	putative hydrophobic ligand binding site [chemical binding]; other site
331272016840	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272016841	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272016842	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272016843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016844	putative substrate translocation pore; other site
331272016845	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272016846	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272016847	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
331272016848	active site
331272016849	catalytic residues [active]
331272016850	metal binding site [ion binding]; metal-binding site
331272016851	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272016852	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272016853	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272016854	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
331272016855	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
331272016856	putative catalytic residue [active]
331272016857	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272016858	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016859	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272016860	putative effector binding pocket; other site
331272016861	dimerization interface [polypeptide binding]; other site
331272016862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016863	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272016864	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331272016865	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
331272016866	active site
331272016867	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272016868	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
331272016869	C-terminal domain interface [polypeptide binding]; other site
331272016870	GSH binding site (G-site) [chemical binding]; other site
331272016871	dimer interface [polypeptide binding]; other site
331272016872	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
331272016873	N-terminal domain interface [polypeptide binding]; other site
331272016874	dimer interface [polypeptide binding]; other site
331272016875	substrate binding pocket (H-site) [chemical binding]; other site
331272016876	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
331272016877	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
331272016878	active site residue [active]
331272016879	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
331272016880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016881	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
331272016882	putative dimerization interface [polypeptide binding]; other site
331272016883	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
331272016884	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
331272016885	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
331272016886	tetramer interface [polypeptide binding]; other site
331272016887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272016888	catalytic residue [active]
331272016889	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
331272016890	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
331272016891	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
331272016892	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
331272016893	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272016894	non-specific DNA binding site [nucleotide binding]; other site
331272016895	salt bridge; other site
331272016896	sequence-specific DNA binding site [nucleotide binding]; other site
331272016897	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
331272016898	HipA-like N-terminal domain; Region: HipA_N; pfam07805
331272016899	HipA-like C-terminal domain; Region: HipA_C; pfam07804
331272016900	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
331272016901	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272016902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272016903	dimer interface [polypeptide binding]; other site
331272016904	conserved gate region; other site
331272016905	putative PBP binding loops; other site
331272016906	ABC-ATPase subunit interface; other site
331272016907	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
331272016908	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
331272016909	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
331272016910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272016911	Walker A/P-loop; other site
331272016912	ATP binding site [chemical binding]; other site
331272016913	Q-loop/lid; other site
331272016914	ABC transporter signature motif; other site
331272016915	Walker B; other site
331272016916	D-loop; other site
331272016917	H-loop/switch region; other site
331272016918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272016919	dimer interface [polypeptide binding]; other site
331272016920	conserved gate region; other site
331272016921	putative PBP binding loops; other site
331272016922	ABC-ATPase subunit interface; other site
331272016923	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272016924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272016925	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272016926	dimerization interface [polypeptide binding]; other site
331272016927	Sulfatase; Region: Sulfatase; cl17466
331272016928	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
331272016929	Sulfatase; Region: Sulfatase; cl17466
331272016930	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
331272016931	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
331272016932	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
331272016933	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
331272016934	Uncharacterized conserved protein [Function unknown]; Region: COG5361
331272016935	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
331272016936	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
331272016937	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331272016938	metal-binding site [ion binding]
331272016939	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331272016940	metal-binding site [ion binding]
331272016941	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331272016942	metal-binding site [ion binding]
331272016943	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
331272016944	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
331272016945	metal-binding site [ion binding]
331272016946	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
331272016947	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272016948	motif II; other site
331272016949	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272016950	MgtC family; Region: MgtC; pfam02308
331272016951	dimerization interface [polypeptide binding]; other site
331272016952	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
331272016953	putative active cleft [active]
331272016954	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
331272016955	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
331272016956	dimer interface [polypeptide binding]; other site
331272016957	ligand binding site [chemical binding]; other site
331272016958	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272016959	dimer interface [polypeptide binding]; other site
331272016960	putative CheW interface [polypeptide binding]; other site
331272016961	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
331272016962	CoenzymeA binding site [chemical binding]; other site
331272016963	subunit interaction site [polypeptide binding]; other site
331272016964	PHB binding site; other site
331272016965	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
331272016966	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272016967	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272016968	Transposase domain (DUF772); Region: DUF772; pfam05598
331272016969	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331272016970	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
331272016971	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272016972	enoyl-CoA hydratase; Provisional; Region: PRK09245
331272016973	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272016974	substrate binding site [chemical binding]; other site
331272016975	oxyanion hole (OAH) forming residues; other site
331272016976	trimer interface [polypeptide binding]; other site
331272016977	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272016978	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272016979	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
331272016980	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272016981	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
331272016982	substrate binding site [chemical binding]; other site
331272016983	oxyanion hole (OAH) forming residues; other site
331272016984	trimer interface [polypeptide binding]; other site
331272016985	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272016986	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272016987	trimer interface [polypeptide binding]; other site
331272016988	eyelet of channel; other site
331272016989	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272016990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272016991	putative substrate translocation pore; other site
331272016992	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272016993	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
331272016994	active site
331272016995	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272016996	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272016997	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272016998	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
331272016999	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
331272017000	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
331272017001	substrate binding site [chemical binding]; other site
331272017002	ligand binding site [chemical binding]; other site
331272017003	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
331272017004	substrate binding site [chemical binding]; other site
331272017005	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
331272017006	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
331272017007	dimer interface [polypeptide binding]; other site
331272017008	active site
331272017009	citrylCoA binding site [chemical binding]; other site
331272017010	oxalacetate/citrate binding site [chemical binding]; other site
331272017011	coenzyme A binding site [chemical binding]; other site
331272017012	catalytic triad [active]
331272017013	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
331272017014	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
331272017015	tetramer interface [polypeptide binding]; other site
331272017016	active site
331272017017	Mg2+/Mn2+ binding site [ion binding]; other site
331272017018	Propionate catabolism activator; Region: PrpR_N; pfam06506
331272017019	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
331272017020	PAS domain; Region: PAS; smart00091
331272017021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272017022	Walker A motif; other site
331272017023	ATP binding site [chemical binding]; other site
331272017024	Walker B motif; other site
331272017025	arginine finger; other site
331272017026	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
331272017027	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
331272017028	CGNR zinc finger; Region: zf-CGNR; pfam11706
331272017029	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
331272017030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272017031	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272017032	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272017033	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272017034	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
331272017035	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272017036	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
331272017037	CoA binding domain; Region: CoA_binding_2; pfam13380
331272017038	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
331272017039	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272017040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272017041	Coenzyme A binding pocket [chemical binding]; other site
331272017042	H-NS histone family; Region: Histone_HNS; pfam00816
331272017043	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272017044	PAS fold; Region: PAS_4; pfam08448
331272017045	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
331272017046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272017047	Walker B motif; other site
331272017048	arginine finger; other site
331272017049	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272017050	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
331272017051	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272017052	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
331272017053	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272017054	putative acetyltransferase YhhY; Provisional; Region: PRK10140
331272017055	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272017056	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
331272017057	Phosphoesterase family; Region: Phosphoesterase; pfam04185
331272017058	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272017059	Domain of unknown function (DUF756); Region: DUF756; pfam05506
331272017060	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
331272017061	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
331272017062	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
331272017063	active site residue [active]
331272017064	outer membrane porin, OprD family; Region: OprD; pfam03573
331272017065	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
331272017066	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272017067	Walker A/P-loop; other site
331272017068	ATP binding site [chemical binding]; other site
331272017069	Q-loop/lid; other site
331272017070	ABC transporter signature motif; other site
331272017071	Walker B; other site
331272017072	D-loop; other site
331272017073	H-loop/switch region; other site
331272017074	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272017075	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
331272017076	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272017077	Walker A/P-loop; other site
331272017078	ATP binding site [chemical binding]; other site
331272017079	Q-loop/lid; other site
331272017080	ABC transporter signature motif; other site
331272017081	Walker B; other site
331272017082	D-loop; other site
331272017083	H-loop/switch region; other site
331272017084	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272017085	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
331272017086	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
331272017087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272017088	dimer interface [polypeptide binding]; other site
331272017089	conserved gate region; other site
331272017090	putative PBP binding loops; other site
331272017091	ABC-ATPase subunit interface; other site
331272017092	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
331272017093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
331272017094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272017095	ABC-ATPase subunit interface; other site
331272017096	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
331272017097	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
331272017098	peptide binding site [polypeptide binding]; other site
331272017099	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
331272017100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272017101	non-specific DNA binding site [nucleotide binding]; other site
331272017102	salt bridge; other site
331272017103	sequence-specific DNA binding site [nucleotide binding]; other site
331272017104	Cupin domain; Region: Cupin_2; pfam07883
331272017105	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
331272017106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017107	putative substrate translocation pore; other site
331272017108	POT family; Region: PTR2; cl17359
331272017109	OpgC protein; Region: OpgC_C; pfam10129
331272017110	Predicted permeases [General function prediction only]; Region: RarD; COG2962
331272017111	acylphosphatase; Provisional; Region: PRK14424
331272017112	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
331272017113	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
331272017114	putative NADP binding site [chemical binding]; other site
331272017115	putative substrate binding site [chemical binding]; other site
331272017116	active site
331272017117	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
331272017118	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
331272017119	active site
331272017120	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272017121	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
331272017122	LytB protein; Region: LYTB; pfam02401
331272017123	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
331272017124	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272017125	FeS/SAM binding site; other site
331272017126	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
331272017127	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272017128	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
331272017129	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
331272017130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017131	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272017132	putative substrate translocation pore; other site
331272017133	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
331272017134	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
331272017135	carbon starvation protein A; Provisional; Region: PRK15015
331272017136	Carbon starvation protein CstA; Region: CstA; pfam02554
331272017137	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
331272017138	Transposase, Mutator family; Region: Transposase_mut; pfam00872
331272017139	MULE transposase domain; Region: MULE; pfam10551
331272017140	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
331272017141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272017142	non-specific DNA binding site [nucleotide binding]; other site
331272017143	salt bridge; other site
331272017144	sequence-specific DNA binding site [nucleotide binding]; other site
331272017145	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
331272017146	Phage integrase protein; Region: DUF3701; pfam12482
331272017147	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
331272017148	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
331272017149	Int/Topo IB signature motif; other site
331272017150	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272017151	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272017152	ligand binding site [chemical binding]; other site
331272017153	flexible hinge region; other site
331272017154	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
331272017155	PRC-barrel domain; Region: PRC; pfam05239
331272017156	PRC-barrel domain; Region: PRC; pfam05239
331272017157	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
331272017158	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
331272017159	TPP-binding site [chemical binding]; other site
331272017160	dimer interface [polypeptide binding]; other site
331272017161	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331272017162	PYR/PP interface [polypeptide binding]; other site
331272017163	dimer interface [polypeptide binding]; other site
331272017164	TPP binding site [chemical binding]; other site
331272017165	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272017166	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
331272017167	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
331272017168	CsbD-like; Region: CsbD; pfam05532
331272017169	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272017170	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
331272017171	Di-iron ligands [ion binding]; other site
331272017172	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
331272017173	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272017174	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272017175	ligand binding site [chemical binding]; other site
331272017176	flexible hinge region; other site
331272017177	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
331272017178	Transposase; Region: DDE_Tnp_ISL3; pfam01610
331272017179	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272017180	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272017181	ligand binding site [chemical binding]; other site
331272017182	flexible hinge region; other site
331272017183	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
331272017184	non-specific DNA interactions [nucleotide binding]; other site
331272017185	DNA binding site [nucleotide binding]
331272017186	sequence specific DNA binding site [nucleotide binding]; other site
331272017187	putative cAMP binding site [chemical binding]; other site
331272017188	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305
331272017189	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
331272017190	Putative glucoamylase; Region: Glycoamylase; pfam10091
331272017191	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
331272017192	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
331272017193	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
331272017194	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
331272017195	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
331272017196	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
331272017197	AAA domain; Region: AAA_22; pfam13401
331272017198	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
331272017199	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331272017200	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
331272017201	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
331272017202	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
331272017203	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
331272017204	DNA binding residues [nucleotide binding]
331272017205	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
331272017206	Uncharacterized conserved protein [Function unknown]; Region: COG2128
331272017207	Cupin domain; Region: Cupin_2; pfam07883
331272017208	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017210	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272017211	putative effector binding pocket; other site
331272017212	dimerization interface [polypeptide binding]; other site
331272017213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272017214	NADH(P)-binding; Region: NAD_binding_10; pfam13460
331272017215	NAD(P) binding site [chemical binding]; other site
331272017216	active site
331272017217	OsmC-like protein; Region: OsmC; cl00767
331272017218	PRC-barrel domain; Region: PRC; pfam05239
331272017219	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
331272017220	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
331272017221	Secretory lipase; Region: LIP; pfam03583
331272017222	hypothetical protein; Provisional; Region: PRK11239
331272017223	Protein of unknown function, DUF480; Region: DUF480; pfam04337
331272017224	short chain dehydrogenase; Provisional; Region: PRK07023
331272017225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272017226	NAD(P) binding site [chemical binding]; other site
331272017227	active site
331272017228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
331272017229	MOSC domain; Region: MOSC; pfam03473
331272017230	3-alpha domain; Region: 3-alpha; pfam03475
331272017231	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272017232	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272017233	inhibitor site; inhibition site
331272017234	active site
331272017235	dimer interface [polypeptide binding]; other site
331272017236	catalytic residue [active]
331272017237	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
331272017238	intersubunit interface [polypeptide binding]; other site
331272017239	active site
331272017240	Zn2+ binding site [ion binding]; other site
331272017241	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272017242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272017243	non-specific DNA binding site [nucleotide binding]; other site
331272017244	salt bridge; other site
331272017245	sequence-specific DNA binding site [nucleotide binding]; other site
331272017246	Cupin domain; Region: Cupin_2; pfam07883
331272017247	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
331272017248	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272017249	DNA-binding site [nucleotide binding]; DNA binding site
331272017250	UTRA domain; Region: UTRA; pfam07702
331272017251	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
331272017252	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
331272017253	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272017254	substrate binding pocket [chemical binding]; other site
331272017255	membrane-bound complex binding site; other site
331272017256	hinge residues; other site
331272017257	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272017258	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272017259	non-specific DNA binding site [nucleotide binding]; other site
331272017260	salt bridge; other site
331272017261	sequence-specific DNA binding site [nucleotide binding]; other site
331272017262	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
331272017263	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017265	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017266	dimerization interface [polypeptide binding]; other site
331272017267	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331272017268	cytosine deaminase; Provisional; Region: PRK05985
331272017269	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
331272017270	active site
331272017271	cytosine deaminase; Provisional; Region: PRK05985
331272017272	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
331272017273	active site
331272017274	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
331272017275	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272017276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272017277	Coenzyme A binding pocket [chemical binding]; other site
331272017278	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272017279	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272017280	metal binding site [ion binding]; metal-binding site
331272017281	putative dimer interface [polypeptide binding]; other site
331272017282	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
331272017283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272017284	catalytic residue [active]
331272017285	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272017286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272017287	putative DNA binding site [nucleotide binding]; other site
331272017288	putative Zn2+ binding site [ion binding]; other site
331272017289	AsnC family; Region: AsnC_trans_reg; pfam01037
331272017290	Tannase and feruloyl esterase; Region: Tannase; pfam07519
331272017291	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272017292	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272017293	trimer interface [polypeptide binding]; other site
331272017294	eyelet of channel; other site
331272017295	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
331272017296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017297	putative substrate translocation pore; other site
331272017298	feruloyl-CoA synthase; Reviewed; Region: PRK08180
331272017299	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
331272017300	acyl-activating enzyme (AAE) consensus motif; other site
331272017301	putative AMP binding site [chemical binding]; other site
331272017302	putative active site [active]
331272017303	putative CoA binding site [chemical binding]; other site
331272017304	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272017305	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
331272017306	NAD(P) binding site [chemical binding]; other site
331272017307	catalytic residues [active]
331272017308	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
331272017309	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272017310	substrate binding site [chemical binding]; other site
331272017311	oxyanion hole (OAH) forming residues; other site
331272017312	trimer interface [polypeptide binding]; other site
331272017313	Transcriptional regulators [Transcription]; Region: MarR; COG1846
331272017314	MarR family; Region: MarR_2; pfam12802
331272017315	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
331272017316	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272017317	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272017318	TM-ABC transporter signature motif; other site
331272017319	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
331272017320	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272017321	Walker A/P-loop; other site
331272017322	ATP binding site [chemical binding]; other site
331272017323	Q-loop/lid; other site
331272017324	ABC transporter signature motif; other site
331272017325	Walker B; other site
331272017326	D-loop; other site
331272017327	H-loop/switch region; other site
331272017328	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272017329	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
331272017330	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
331272017331	ligand binding site [chemical binding]; other site
331272017332	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
331272017333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
331272017334	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272017335	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272017336	inhibitor site; inhibition site
331272017337	active site
331272017338	dimer interface [polypeptide binding]; other site
331272017339	catalytic residue [active]
331272017340	dihydroxy-acid dehydratase; Validated; Region: PRK06131
331272017341	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
331272017342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017343	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017344	dimerization interface [polypeptide binding]; other site
331272017345	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
331272017346	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272017347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272017348	DNA-binding site [nucleotide binding]; DNA binding site
331272017349	FCD domain; Region: FCD; pfam07729
331272017350	BON domain; Region: BON; pfam04972
331272017351	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272017352	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272017353	eyelet of channel; other site
331272017354	trimer interface [polypeptide binding]; other site
331272017355	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
331272017356	Sulfatase; Region: Sulfatase; pfam00884
331272017357	Sulfatase; Region: Sulfatase; cl17466
331272017358	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
331272017359	Uncharacterized conserved protein [Function unknown]; Region: COG1262
331272017360	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
331272017361	beta-galactosidase; Region: BGL; TIGR03356
331272017362	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
331272017363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017365	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272017366	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272017367	DNA binding site [nucleotide binding]
331272017368	domain linker motif; other site
331272017369	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
331272017370	dimerization interface [polypeptide binding]; other site
331272017371	ligand binding site [chemical binding]; other site
331272017372	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
331272017373	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272017374	Walker A/P-loop; other site
331272017375	ATP binding site [chemical binding]; other site
331272017376	Q-loop/lid; other site
331272017377	ABC transporter signature motif; other site
331272017378	Walker B; other site
331272017379	D-loop; other site
331272017380	H-loop/switch region; other site
331272017381	TOBE domain; Region: TOBE_2; pfam08402
331272017382	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
331272017383	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
331272017384	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
331272017385	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272017386	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272017387	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272017388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272017389	dimer interface [polypeptide binding]; other site
331272017390	conserved gate region; other site
331272017391	putative PBP binding loops; other site
331272017392	ABC-ATPase subunit interface; other site
331272017393	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272017394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272017395	dimer interface [polypeptide binding]; other site
331272017396	conserved gate region; other site
331272017397	putative PBP binding loops; other site
331272017398	ABC-ATPase subunit interface; other site
331272017399	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
331272017400	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272017401	EamA-like transporter family; Region: EamA; pfam00892
331272017402	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
331272017403	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272017404	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272017405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017406	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272017407	dimerization interface [polypeptide binding]; other site
331272017408	substrate binding pocket [chemical binding]; other site
331272017409	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
331272017410	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
331272017411	ATP binding site [chemical binding]; other site
331272017412	Mg++ binding site [ion binding]; other site
331272017413	motif III; other site
331272017414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272017415	nucleotide binding region [chemical binding]; other site
331272017416	ATP-binding site [chemical binding]; other site
331272017417	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
331272017418	malate synthase G; Provisional; Region: PRK02999
331272017419	active site
331272017420	Cache domain; Region: Cache_1; pfam02743
331272017421	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272017422	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272017423	metal binding site [ion binding]; metal-binding site
331272017424	active site
331272017425	I-site; other site
331272017426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
331272017427	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
331272017428	Histidine kinase; Region: HisKA_3; pfam07730
331272017429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272017430	ATP binding site [chemical binding]; other site
331272017431	Mg2+ binding site [ion binding]; other site
331272017432	G-X-G motif; other site
331272017433	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272017434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272017435	active site
331272017436	phosphorylation site [posttranslational modification]
331272017437	intermolecular recognition site; other site
331272017438	dimerization interface [polypeptide binding]; other site
331272017439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272017440	DNA binding residues [nucleotide binding]
331272017441	dimerization interface [polypeptide binding]; other site
331272017442	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272017443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017444	putative substrate translocation pore; other site
331272017445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017447	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
331272017448	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
331272017449	VacJ like lipoprotein; Region: VacJ; cl01073
331272017450	hypothetical protein; Provisional; Region: PRK07077
331272017451	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
331272017452	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
331272017453	Active site cavity [active]
331272017454	catalytic acid [active]
331272017455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272017456	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
331272017457	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
331272017458	active site lid residues [active]
331272017459	substrate binding pocket [chemical binding]; other site
331272017460	catalytic residues [active]
331272017461	substrate-Mg2+ binding site; other site
331272017462	aspartate-rich region 1; other site
331272017463	aspartate-rich region 2; other site
331272017464	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
331272017465	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272017466	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272017467	PAS domain; Region: PAS_9; pfam13426
331272017468	putative active site [active]
331272017469	heme pocket [chemical binding]; other site
331272017470	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
331272017471	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272017472	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272017473	metal binding site [ion binding]; metal-binding site
331272017474	active site
331272017475	I-site; other site
331272017476	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
331272017477	Response regulator receiver domain; Region: Response_reg; pfam00072
331272017478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272017479	active site
331272017480	phosphorylation site [posttranslational modification]
331272017481	intermolecular recognition site; other site
331272017482	dimerization interface [polypeptide binding]; other site
331272017483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272017484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272017485	dimer interface [polypeptide binding]; other site
331272017486	phosphorylation site [posttranslational modification]
331272017487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272017488	ATP binding site [chemical binding]; other site
331272017489	Mg2+ binding site [ion binding]; other site
331272017490	G-X-G motif; other site
331272017491	Response regulator receiver domain; Region: Response_reg; pfam00072
331272017492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272017493	active site
331272017494	phosphorylation site [posttranslational modification]
331272017495	intermolecular recognition site; other site
331272017496	dimerization interface [polypeptide binding]; other site
331272017497	Predicted flavoprotein [General function prediction only]; Region: COG0431
331272017498	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272017499	RNA polymerase sigma factor; Provisional; Region: PRK12545
331272017500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
331272017501	Putative zinc-finger; Region: zf-HC2; pfam13490
331272017502	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
331272017503	ArsC family; Region: ArsC; pfam03960
331272017504	catalytic residues [active]
331272017505	ParA-like protein; Provisional; Region: PHA02518
331272017506	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272017507	P-loop; other site
331272017508	Magnesium ion binding site [ion binding]; other site
331272017509	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
331272017510	ParB-like nuclease domain; Region: ParB; smart00470
331272017511	Initiator Replication protein; Region: Rep_3; pfam01051
331272017512	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
331272017513	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
331272017514	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331272017515	active site
331272017516	catalytic residues [active]
331272017517	Int/Topo IB signature motif; other site
331272017518	DNA binding site [nucleotide binding]
331272017519	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
331272017520	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272017521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272017522	non-specific DNA binding site [nucleotide binding]; other site
331272017523	salt bridge; other site
331272017524	sequence-specific DNA binding site [nucleotide binding]; other site
331272017525	Cupin domain; Region: Cupin_2; pfam07883
331272017526	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
331272017527	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
331272017528	substrate-cofactor binding pocket; other site
331272017529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272017530	catalytic residue [active]
331272017531	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
331272017532	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
331272017533	NAD(P) binding site [chemical binding]; other site
331272017534	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017535	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
331272017537	SnoaL-like domain; Region: SnoaL_2; pfam12680
331272017538	tartrate dehydrogenase; Region: TTC; TIGR02089
331272017539	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
331272017540	transcriptional activator TtdR; Provisional; Region: PRK09801
331272017541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017542	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
331272017543	putative effector binding pocket; other site
331272017544	putative dimerization interface [polypeptide binding]; other site
331272017545	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
331272017546	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
331272017547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017549	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272017550	dimerization interface [polypeptide binding]; other site
331272017551	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
331272017552	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
331272017553	nucleophile elbow; other site
331272017554	Patatin phospholipase; Region: DUF3734; pfam12536
331272017555	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
331272017556	classical (c) SDRs; Region: SDR_c; cd05233
331272017557	NAD(P) binding site [chemical binding]; other site
331272017558	active site
331272017559	acetoacetate decarboxylase; Provisional; Region: PRK02265
331272017560	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331272017561	active site
331272017562	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
331272017563	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
331272017564	FAD binding pocket [chemical binding]; other site
331272017565	FAD binding motif [chemical binding]; other site
331272017566	phosphate binding motif [ion binding]; other site
331272017567	NAD binding pocket [chemical binding]; other site
331272017568	Predicted transcriptional regulators [Transcription]; Region: COG1695
331272017569	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
331272017570	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
331272017571	phosphopeptide binding site; other site
331272017572	Catalytic domain of Protein Kinases; Region: PKc; cd00180
331272017573	active site
331272017574	ATP binding site [chemical binding]; other site
331272017575	substrate binding site [chemical binding]; other site
331272017576	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
331272017577	activation loop (A-loop); other site
331272017578	cyclase homology domain; Region: CHD; cd07302
331272017579	nucleotidyl binding site; other site
331272017580	metal binding site [ion binding]; metal-binding site
331272017581	AAA ATPase domain; Region: AAA_16; pfam13191
331272017582	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
331272017583	ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795
331272017584	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
331272017585	YcaO-like family; Region: YcaO; pfam02624
331272017586	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
331272017587	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272017588	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272017589	trimer interface [polypeptide binding]; other site
331272017590	eyelet of channel; other site
331272017591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272017592	classical (c) SDRs; Region: SDR_c; cd05233
331272017593	NAD(P) binding site [chemical binding]; other site
331272017594	active site
331272017595	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272017596	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
331272017597	putative NAD(P) binding site [chemical binding]; other site
331272017598	catalytic Zn binding site [ion binding]; other site
331272017599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017600	D-galactonate transporter; Region: 2A0114; TIGR00893
331272017601	putative substrate translocation pore; other site
331272017602	Cupin domain; Region: Cupin_2; pfam07883
331272017603	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272017604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272017605	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272017606	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272017607	active site
331272017608	catalytic tetrad [active]
331272017609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272017610	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272017611	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272017612	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272017613	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272017614	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
331272017615	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
331272017616	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
331272017617	Lysine efflux permease [General function prediction only]; Region: COG1279
331272017618	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
331272017619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017621	dimerization interface [polypeptide binding]; other site
331272017622	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
331272017623	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272017624	ligand binding site [chemical binding]; other site
331272017625	flexible hinge region; other site
331272017626	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
331272017627	putative switch regulator; other site
331272017628	non-specific DNA interactions [nucleotide binding]; other site
331272017629	DNA binding site [nucleotide binding]
331272017630	sequence specific DNA binding site [nucleotide binding]; other site
331272017631	putative cAMP binding site [chemical binding]; other site
331272017632	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272017633	Ligand Binding Site [chemical binding]; other site
331272017634	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
331272017635	serine O-acetyltransferase; Region: cysE; TIGR01172
331272017636	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
331272017637	trimer interface [polypeptide binding]; other site
331272017638	active site
331272017639	substrate binding site [chemical binding]; other site
331272017640	CoA binding site [chemical binding]; other site
331272017641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272017642	short chain dehydrogenase; Provisional; Region: PRK09134
331272017643	NAD(P) binding site [chemical binding]; other site
331272017644	active site
331272017645	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
331272017646	GTP cyclohydrolase I; Provisional; Region: PLN03044
331272017647	active site
331272017648	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017650	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
331272017651	substrate binding pocket [chemical binding]; other site
331272017652	dimerization interface [polypeptide binding]; other site
331272017653	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
331272017654	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272017655	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
331272017656	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
331272017657	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
331272017658	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
331272017659	tetramer interface [polypeptide binding]; other site
331272017660	active site
331272017661	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331272017662	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
331272017663	benzoate transport; Region: 2A0115; TIGR00895
331272017664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017665	putative substrate translocation pore; other site
331272017666	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272017667	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
331272017668	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272017669	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272017670	ligand binding site [chemical binding]; other site
331272017671	flexible hinge region; other site
331272017672	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
331272017673	Winged helix-turn helix; Region: HTH_29; pfam13551
331272017674	Helix-turn-helix domain; Region: HTH_28; pfam13518
331272017675	Homeodomain-like domain; Region: HTH_32; pfam13565
331272017676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
331272017677	Integrase core domain; Region: rve; pfam00665
331272017678	Integrase core domain; Region: rve_3; pfam13683
331272017679	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272017680	DNA-binding site [nucleotide binding]; DNA binding site
331272017681	RNA-binding motif; other site
331272017682	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
331272017683	rRNA binding site [nucleotide binding]; other site
331272017684	predicted 30S ribosome binding site; other site
331272017685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272017686	Radical SAM superfamily; Region: Radical_SAM; pfam04055
331272017687	FeS/SAM binding site; other site
331272017688	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
331272017689	Biofilm formation and stress response factor; Region: BsmA; pfam10014
331272017690	H+ Antiporter protein; Region: 2A0121; TIGR00900
331272017691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017693	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
331272017694	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272017695	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
331272017696	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
331272017697	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
331272017698	putative active site [active]
331272017699	putative metal binding site [ion binding]; other site
331272017700	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272017701	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272017702	AMP-binding domain protein; Validated; Region: PRK07529
331272017703	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272017704	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
331272017705	acyl-activating enzyme (AAE) consensus motif; other site
331272017706	putative AMP binding site [chemical binding]; other site
331272017707	putative active site [active]
331272017708	putative CoA binding site [chemical binding]; other site
331272017709	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
331272017710	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
331272017711	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
331272017712	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
331272017713	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
331272017714	putative active site [active]
331272017715	putative metal binding site [ion binding]; other site
331272017716	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272017717	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
331272017718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017720	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272017721	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331272017722	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
331272017723	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
331272017724	SurA N-terminal domain; Region: SurA_N_3; cl07813
331272017725	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
331272017726	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272017727	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272017728	MASE1; Region: MASE1; pfam05231
331272017729	PAS fold; Region: PAS_3; pfam08447
331272017730	Esterase/lipase [General function prediction only]; Region: COG1647
331272017731	Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140
331272017732	putative RNAase interaction site [polypeptide binding]; other site
331272017733	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331272017734	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
331272017735	DNA binding residues [nucleotide binding]
331272017736	dimer interface [polypeptide binding]; other site
331272017737	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
331272017738	N- and C-terminal domain interface [polypeptide binding]; other site
331272017739	D-xylulose kinase; Region: XylB; TIGR01312
331272017740	active site
331272017741	MgATP binding site [chemical binding]; other site
331272017742	catalytic site [active]
331272017743	metal binding site [ion binding]; metal-binding site
331272017744	xylulose binding site [chemical binding]; other site
331272017745	homodimer interface [polypeptide binding]; other site
331272017746	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
331272017747	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272017748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272017749	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
331272017750	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272017751	Walker A/P-loop; other site
331272017752	ATP binding site [chemical binding]; other site
331272017753	Q-loop/lid; other site
331272017754	ABC transporter signature motif; other site
331272017755	Walker B; other site
331272017756	D-loop; other site
331272017757	H-loop/switch region; other site
331272017758	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272017759	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
331272017760	inhibitor binding site; inhibition site
331272017761	catalytic Zn binding site [ion binding]; other site
331272017762	structural Zn binding site [ion binding]; other site
331272017763	NADP binding site [chemical binding]; other site
331272017764	tetramer interface [polypeptide binding]; other site
331272017765	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272017766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272017767	dimer interface [polypeptide binding]; other site
331272017768	conserved gate region; other site
331272017769	putative PBP binding loops; other site
331272017770	ABC-ATPase subunit interface; other site
331272017771	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
331272017772	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
331272017773	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272017774	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272017775	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272017776	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272017777	Uncharacterized conserved protein [Function unknown]; Region: COG3391
331272017778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017779	D-galactonate transporter; Region: 2A0114; TIGR00893
331272017780	putative substrate translocation pore; other site
331272017781	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272017782	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272017783	inhibitor site; inhibition site
331272017784	active site
331272017785	dimer interface [polypeptide binding]; other site
331272017786	catalytic residue [active]
331272017787	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
331272017788	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
331272017789	putative active site pocket [active]
331272017790	putative metal binding site [ion binding]; other site
331272017791	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
331272017792	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
331272017793	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017794	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017795	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017796	dimerization interface [polypeptide binding]; other site
331272017797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017798	D-galactonate transporter; Region: 2A0114; TIGR00893
331272017799	putative substrate translocation pore; other site
331272017800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272017801	HAMP domain; Region: HAMP; pfam00672
331272017802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272017803	dimer interface [polypeptide binding]; other site
331272017804	phosphorylation site [posttranslational modification]
331272017805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272017806	Mg2+ binding site [ion binding]; other site
331272017807	G-X-G motif; other site
331272017808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272017809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272017810	active site
331272017811	phosphorylation site [posttranslational modification]
331272017812	intermolecular recognition site; other site
331272017813	dimerization interface [polypeptide binding]; other site
331272017814	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272017815	DNA binding site [nucleotide binding]
331272017816	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
331272017817	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272017818	Cytochrome c; Region: Cytochrom_C; cl11414
331272017819	Cytochrome c; Region: Cytochrom_C; cl11414
331272017820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017821	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017822	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
331272017823	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
331272017824	homotrimer interaction site [polypeptide binding]; other site
331272017825	putative active site [active]
331272017826	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
331272017827	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
331272017828	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
331272017829	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
331272017830	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
331272017831	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272017832	Cytochrome c; Region: Cytochrom_C; cl11414
331272017833	Cytochrome c; Region: Cytochrom_C; cl11414
331272017834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272017835	NAD(P) binding site [chemical binding]; other site
331272017836	acyl-CoA synthetase; Validated; Region: PRK06188
331272017837	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272017838	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
331272017839	acyl-activating enzyme (AAE) consensus motif; other site
331272017840	acyl-activating enzyme (AAE) consensus motif; other site
331272017841	putative AMP binding site [chemical binding]; other site
331272017842	putative active site [active]
331272017843	putative CoA binding site [chemical binding]; other site
331272017844	lipid-transfer protein; Provisional; Region: PRK08256
331272017845	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
331272017846	active site
331272017847	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272017848	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272017849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272017850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272017851	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
331272017852	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272017853	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272017854	active site
331272017855	chaperone protein HchA; Provisional; Region: PRK04155
331272017856	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
331272017857	conserved cys residue [active]
331272017858	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
331272017859	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272017860	acyl-activating enzyme (AAE) consensus motif; other site
331272017861	AMP binding site [chemical binding]; other site
331272017862	active site
331272017863	CoA binding site [chemical binding]; other site
331272017864	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
331272017865	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272017866	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272017867	DNA binding residues [nucleotide binding]
331272017868	dimerization interface [polypeptide binding]; other site
331272017869	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017870	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017871	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017872	dimerization interface [polypeptide binding]; other site
331272017873	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
331272017874	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
331272017875	NAD(P) binding site [chemical binding]; other site
331272017876	transcriptional regulator; Provisional; Region: PRK10632
331272017877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017878	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272017879	putative effector binding pocket; other site
331272017880	dimerization interface [polypeptide binding]; other site
331272017881	BON domain; Region: BON; pfam04972
331272017882	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
331272017883	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
331272017884	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
331272017885	catalytic core [active]
331272017886	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
331272017887	Phosphotransferase enzyme family; Region: APH; pfam01636
331272017888	putative active site [active]
331272017889	putative substrate binding site [chemical binding]; other site
331272017890	ATP binding site [chemical binding]; other site
331272017891	short chain dehydrogenase; Provisional; Region: PRK07035
331272017892	classical (c) SDRs; Region: SDR_c; cd05233
331272017893	NAD(P) binding site [chemical binding]; other site
331272017894	active site
331272017895	short chain dehydrogenase; Provisional; Region: PRK06172
331272017896	classical (c) SDRs; Region: SDR_c; cd05233
331272017897	NAD(P) binding site [chemical binding]; other site
331272017898	active site
331272017899	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272017900	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272017901	active site
331272017902	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
331272017903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017904	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
331272017905	substrate binding pocket [chemical binding]; other site
331272017906	dimerization interface [polypeptide binding]; other site
331272017907	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
331272017908	HSP70 interaction site [polypeptide binding]; other site
331272017909	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272017910	DNA polymerase II; Reviewed; Region: PRK05762
331272017911	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
331272017912	active site
331272017913	catalytic site [active]
331272017914	substrate binding site [chemical binding]; other site
331272017915	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
331272017916	active site
331272017917	metal-binding site
331272017918	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
331272017919	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
331272017920	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
331272017921	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272017922	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
331272017923	pyrophosphatase PpaX; Provisional; Region: PRK13288
331272017924	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
331272017925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272017926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272017927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017929	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
331272017930	putative dimerization interface [polypeptide binding]; other site
331272017931	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272017932	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272017933	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272017934	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
331272017935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272017936	NAD(P) binding site [chemical binding]; other site
331272017937	active site
331272017938	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272017939	ligand binding site [chemical binding]; other site
331272017940	benzoate transporter; Region: benE; TIGR00843
331272017941	Benzoate membrane transport protein; Region: BenE; pfam03594
331272017942	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
331272017943	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272017944	putative di-iron ligands [ion binding]; other site
331272017945	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
331272017946	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
331272017947	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
331272017948	putative Mg++ binding site [ion binding]; other site
331272017949	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
331272017950	nucleotide binding region [chemical binding]; other site
331272017951	ATP-binding site [chemical binding]; other site
331272017952	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
331272017953	putative RNA binding site [nucleotide binding]; other site
331272017954	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
331272017955	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
331272017956	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
331272017957	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
331272017958	Ligand binding site; other site
331272017959	Putative Catalytic site; other site
331272017960	DXD motif; other site
331272017961	Predicted membrane protein [Function unknown]; Region: COG2246
331272017962	GtrA-like protein; Region: GtrA; pfam04138
331272017963	Inclusion body protein; Region: PixA; pfam12306
331272017964	Inclusion body protein; Region: PixA; pfam12306
331272017965	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272017966	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272017967	substrate binding pocket [chemical binding]; other site
331272017968	membrane-bound complex binding site; other site
331272017969	hinge residues; other site
331272017970	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272017971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017972	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272017973	putative substrate translocation pore; other site
331272017974	hypothetical protein; Provisional; Region: PRK07206
331272017975	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
331272017976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017978	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017979	dimerization interface [polypeptide binding]; other site
331272017980	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
331272017981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272017982	putative substrate translocation pore; other site
331272017983	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272017984	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
331272017985	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017986	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272017987	dimerization interface [polypeptide binding]; other site
331272017988	substrate binding pocket [chemical binding]; other site
331272017989	NIPSNAP; Region: NIPSNAP; pfam07978
331272017990	NIPSNAP; Region: NIPSNAP; pfam07978
331272017991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272017992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272017993	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272017994	dimerization interface [polypeptide binding]; other site
331272017995	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
331272017996	DNA-binding site [nucleotide binding]; DNA binding site
331272017997	RNA-binding motif; other site
331272017998	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272017999	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272018000	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272018001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018003	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018004	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018005	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
331272018006	substrate binding pocket [chemical binding]; other site
331272018007	dimerization interface [polypeptide binding]; other site
331272018008	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
331272018009	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272018010	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272018011	active site
331272018012	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
331272018013	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
331272018014	active site
331272018015	catalytic site [active]
331272018016	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272018017	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272018018	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
331272018019	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
331272018020	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
331272018021	shikimate binding site; other site
331272018022	NAD(P) binding site [chemical binding]; other site
331272018023	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
331272018024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018025	putative substrate translocation pore; other site
331272018026	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
331272018027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272018028	S-adenosylmethionine binding site [chemical binding]; other site
331272018029	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
331272018030	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
331272018031	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272018032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018033	putative substrate translocation pore; other site
331272018034	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018035	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018036	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018037	dimerization interface [polypeptide binding]; other site
331272018038	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
331272018039	tartrate dehydrogenase; Region: TTC; TIGR02089
331272018040	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272018041	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
331272018042	NAD(P) binding site [chemical binding]; other site
331272018043	catalytic residues [active]
331272018044	catalytic residues [active]
331272018045	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
331272018046	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
331272018047	dimer interface [polypeptide binding]; other site
331272018048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018049	catalytic residue [active]
331272018050	MAPEG family; Region: MAPEG; pfam01124
331272018051	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
331272018052	NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs; Region: NmrA_TMR_like_SDR_a; cd08947
331272018053	NADP binding site [chemical binding]; other site
331272018054	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018056	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272018057	putative effector binding pocket; other site
331272018058	dimerization interface [polypeptide binding]; other site
331272018059	Probable transposase; Region: OrfB_IS605; pfam01385
331272018060	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
331272018061	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
331272018062	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
331272018063	conserved cys residue [active]
331272018064	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
331272018065	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272018066	NADP binding site [chemical binding]; other site
331272018067	active site
331272018068	steroid binding site; other site
331272018069	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272018070	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272018071	DNA-binding site [nucleotide binding]; DNA binding site
331272018072	FCD domain; Region: FCD; pfam07729
331272018073	aminotransferase; Validated; Region: PRK07046
331272018074	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272018075	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272018076	catalytic residue [active]
331272018077	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
331272018078	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
331272018079	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
331272018080	short chain dehydrogenase; Provisional; Region: PRK06500
331272018081	classical (c) SDRs; Region: SDR_c; cd05233
331272018082	NAD(P) binding site [chemical binding]; other site
331272018083	active site
331272018084	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272018085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018086	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272018087	putative effector binding pocket; other site
331272018088	dimerization interface [polypeptide binding]; other site
331272018089	transcriptional regulator, ArgP family; Region: argP; TIGR03298
331272018090	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331272018091	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018092	substrate binding pocket [chemical binding]; other site
331272018093	membrane-bound complex binding site; other site
331272018094	hinge residues; other site
331272018095	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272018096	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272018097	Walker A/P-loop; other site
331272018098	ATP binding site [chemical binding]; other site
331272018099	Q-loop/lid; other site
331272018100	ABC transporter signature motif; other site
331272018101	Walker B; other site
331272018102	D-loop; other site
331272018103	H-loop/switch region; other site
331272018104	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272018105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272018106	dimer interface [polypeptide binding]; other site
331272018107	conserved gate region; other site
331272018108	putative PBP binding loops; other site
331272018109	ABC-ATPase subunit interface; other site
331272018110	allophanate hydrolase; Provisional; Region: PRK08186
331272018111	Amidase; Region: Amidase; cl11426
331272018112	urea carboxylase; Region: urea_carbox; TIGR02712
331272018113	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
331272018114	ATP-grasp domain; Region: ATP-grasp_4; cl17255
331272018115	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
331272018116	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
331272018117	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
331272018118	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
331272018119	carboxyltransferase (CT) interaction site; other site
331272018120	biotinylation site [posttranslational modification]; other site
331272018121	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
331272018122	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
331272018123	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
331272018124	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
331272018125	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018126	substrate binding pocket [chemical binding]; other site
331272018127	membrane-bound complex binding site; other site
331272018128	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
331272018129	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
331272018130	hexamer interface [polypeptide binding]; other site
331272018131	active site
331272018132	metal binding site [ion binding]; metal-binding site
331272018133	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
331272018134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
331272018135	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
331272018136	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
331272018137	nudix motif; other site
331272018138	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
331272018139	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
331272018140	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018141	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018142	dimerization interface [polypeptide binding]; other site
331272018143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272018144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272018145	dimer interface [polypeptide binding]; other site
331272018146	phosphorylation site [posttranslational modification]
331272018147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272018148	ATP binding site [chemical binding]; other site
331272018149	Mg2+ binding site [ion binding]; other site
331272018150	G-X-G motif; other site
331272018151	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
331272018152	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
331272018153	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
331272018154	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
331272018155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272018156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272018157	dimer interface [polypeptide binding]; other site
331272018158	phosphorylation site [posttranslational modification]
331272018159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272018160	ATP binding site [chemical binding]; other site
331272018161	Mg2+ binding site [ion binding]; other site
331272018162	G-X-G motif; other site
331272018163	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
331272018164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272018165	active site
331272018166	phosphorylation site [posttranslational modification]
331272018167	intermolecular recognition site; other site
331272018168	dimerization interface [polypeptide binding]; other site
331272018169	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272018170	Zn2+ binding site [ion binding]; other site
331272018171	Mg2+ binding site [ion binding]; other site
331272018172	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
331272018173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272018174	Coenzyme A binding pocket [chemical binding]; other site
331272018175	RNase II stability modulator; Provisional; Region: PRK10060
331272018176	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
331272018177	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272018178	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
331272018179	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272018180	DNA-binding site [nucleotide binding]; DNA binding site
331272018181	FCD domain; Region: FCD; pfam07729
331272018182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272018183	Coenzyme A binding pocket [chemical binding]; other site
331272018184	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272018185	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272018186	eyelet of channel; other site
331272018187	trimer interface [polypeptide binding]; other site
331272018188	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018189	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018190	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272018191	dimerization interface [polypeptide binding]; other site
331272018192	substrate binding pocket [chemical binding]; other site
331272018193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018194	putative substrate translocation pore; other site
331272018195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272018196	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
331272018197	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
331272018198	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
331272018199	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272018200	Putative amidotransferase; Region: DUF4066; pfam13278
331272018201	conserved cys residue [active]
331272018202	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
331272018203	Uncharacterized conserved protein [Function unknown]; Region: COG4275
331272018204	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
331272018205	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
331272018206	Chromate transporter; Region: Chromate_transp; pfam02417
331272018207	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
331272018208	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
331272018209	Transposase domain (DUF772); Region: DUF772; pfam05598
331272018210	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331272018211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272018212	HAMP domain; Region: HAMP; pfam00672
331272018213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272018214	dimer interface [polypeptide binding]; other site
331272018215	phosphorylation site [posttranslational modification]
331272018216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272018217	ATP binding site [chemical binding]; other site
331272018218	Mg2+ binding site [ion binding]; other site
331272018219	G-X-G motif; other site
331272018220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272018221	active site
331272018222	phosphorylation site [posttranslational modification]
331272018223	intermolecular recognition site; other site
331272018224	dimerization interface [polypeptide binding]; other site
331272018225	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272018226	DNA binding site [nucleotide binding]
331272018227	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
331272018228	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272018229	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272018230	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331272018231	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272018232	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
331272018233	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018234	substrate binding pocket [chemical binding]; other site
331272018235	membrane-bound complex binding site; other site
331272018236	hinge residues; other site
331272018237	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
331272018238	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
331272018239	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
331272018240	catalytic residue [active]
331272018241	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
331272018242	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272018243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018245	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
331272018246	dimerization interface [polypeptide binding]; other site
331272018247	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
331272018248	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272018249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018250	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272018251	substrate binding pocket [chemical binding]; other site
331272018252	membrane-bound complex binding site; other site
331272018253	hinge residues; other site
331272018254	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
331272018255	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331272018256	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331272018257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272018258	Walker A/P-loop; other site
331272018259	ATP binding site [chemical binding]; other site
331272018260	Q-loop/lid; other site
331272018261	ABC transporter signature motif; other site
331272018262	Walker B; other site
331272018263	D-loop; other site
331272018264	H-loop/switch region; other site
331272018265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272018266	Walker A/P-loop; other site
331272018267	ATP binding site [chemical binding]; other site
331272018268	Q-loop/lid; other site
331272018269	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
331272018270	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
331272018271	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
331272018272	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
331272018273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018275	Putative cyclase; Region: Cyclase; pfam04199
331272018276	fumarylacetoacetase; Region: PLN02856
331272018277	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
331272018278	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272018279	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272018280	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272018281	trimer interface [polypeptide binding]; other site
331272018282	eyelet of channel; other site
331272018283	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018284	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018285	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
331272018286	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
331272018287	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
331272018288	ligand binding site [chemical binding]; other site
331272018289	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
331272018290	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272018291	trimer interface [polypeptide binding]; other site
331272018292	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272018293	trimer interface [polypeptide binding]; other site
331272018294	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
331272018295	trimer interface [polypeptide binding]; other site
331272018296	YadA-like C-terminal region; Region: YadA; pfam03895
331272018297	Response regulator receiver domain; Region: Response_reg; pfam00072
331272018298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272018299	active site
331272018300	phosphorylation site [posttranslational modification]
331272018301	intermolecular recognition site; other site
331272018302	dimerization interface [polypeptide binding]; other site
331272018303	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272018304	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018305	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
331272018306	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
331272018307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272018308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272018309	dimer interface [polypeptide binding]; other site
331272018310	phosphorylation site [posttranslational modification]
331272018311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272018312	ATP binding site [chemical binding]; other site
331272018313	Mg2+ binding site [ion binding]; other site
331272018314	G-X-G motif; other site
331272018315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272018316	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272018317	TM-ABC transporter signature motif; other site
331272018318	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272018319	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272018320	TM-ABC transporter signature motif; other site
331272018321	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272018322	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272018323	Walker A/P-loop; other site
331272018324	ATP binding site [chemical binding]; other site
331272018325	Q-loop/lid; other site
331272018326	ABC transporter signature motif; other site
331272018327	Walker B; other site
331272018328	D-loop; other site
331272018329	H-loop/switch region; other site
331272018330	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272018331	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
331272018332	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272018333	putative ligand binding site [chemical binding]; other site
331272018334	Pirin-related protein [General function prediction only]; Region: COG1741
331272018335	Pirin; Region: Pirin; pfam02678
331272018336	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
331272018337	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272018338	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018340	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272018341	putative effector binding pocket; other site
331272018342	dimerization interface [polypeptide binding]; other site
331272018343	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
331272018344	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
331272018345	active site
331272018346	DNA binding site [nucleotide binding]
331272018347	Int/Topo IB signature motif; other site
331272018348	catalytic residues [active]
331272018349	proline/glycine betaine transporter; Provisional; Region: PRK10642
331272018350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018351	putative substrate translocation pore; other site
331272018352	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331272018353	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
331272018354	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018356	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272018357	dimerization interface [polypeptide binding]; other site
331272018358	substrate binding pocket [chemical binding]; other site
331272018359	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
331272018360	dinuclear metal binding motif [ion binding]; other site
331272018361	Fatty acid desaturase; Region: FA_desaturase; pfam00487
331272018362	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
331272018363	putative di-iron ligands [ion binding]; other site
331272018364	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
331272018365	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
331272018366	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
331272018367	acyl-activating enzyme (AAE) consensus motif; other site
331272018368	active site
331272018369	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
331272018370	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
331272018371	Walker A/P-loop; other site
331272018372	ATP binding site [chemical binding]; other site
331272018373	Q-loop/lid; other site
331272018374	ABC transporter signature motif; other site
331272018375	Walker B; other site
331272018376	D-loop; other site
331272018377	H-loop/switch region; other site
331272018378	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
331272018379	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
331272018380	FtsX-like permease family; Region: FtsX; pfam02687
331272018381	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
331272018382	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
331272018383	dinuclear metal binding motif [ion binding]; other site
331272018384	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
331272018385	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
331272018386	dimer interface [polypeptide binding]; other site
331272018387	active site
331272018388	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810
331272018389	dimer interface [polypeptide binding]; other site
331272018390	active site
331272018391	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
331272018392	catalytic residues [active]
331272018393	substrate binding site [chemical binding]; other site
331272018394	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
331272018395	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272018396	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
331272018397	acyl-activating enzyme (AAE) consensus motif; other site
331272018398	acyl-activating enzyme (AAE) consensus motif; other site
331272018399	AMP binding site [chemical binding]; other site
331272018400	active site
331272018401	CoA binding site [chemical binding]; other site
331272018402	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272018403	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272018404	active site
331272018405	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
331272018406	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
331272018407	citrylCoA binding site [chemical binding]; other site
331272018408	oxalacetate binding site [chemical binding]; other site
331272018409	coenzyme A binding site [chemical binding]; other site
331272018410	catalytic triad [active]
331272018411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272018412	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272018413	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
331272018414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272018415	Walker A/P-loop; other site
331272018416	ATP binding site [chemical binding]; other site
331272018417	Q-loop/lid; other site
331272018418	ABC transporter signature motif; other site
331272018419	Walker B; other site
331272018420	D-loop; other site
331272018421	H-loop/switch region; other site
331272018422	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
331272018423	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272018424	FAD binding domain; Region: FAD_binding_4; pfam01565
331272018425	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
331272018426	DctM-like transporters; Region: DctM; pfam06808
331272018427	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
331272018428	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
331272018429	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
331272018430	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
331272018431	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
331272018432	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
331272018433	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
331272018434	dimerization interface [polypeptide binding]; other site
331272018435	DNA binding residues [nucleotide binding]
331272018436	cinnamoyl-CoA reductase; Region: PLN02214
331272018437	flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958
331272018438	NADP binding site [chemical binding]; other site
331272018439	substrate binding site [chemical binding]; other site
331272018440	active site
331272018441	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272018442	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272018443	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018444	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
331272018445	homotrimer interaction site [polypeptide binding]; other site
331272018446	putative active site [active]
331272018447	H-NS histone family; Region: Histone_HNS; pfam00816
331272018448	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272018449	Cupin domain; Region: Cupin_2; pfam07883
331272018450	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018452	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018453	dimerization interface [polypeptide binding]; other site
331272018454	LysE type translocator; Region: LysE; cl00565
331272018455	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
331272018456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018457	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018458	dimerization interface [polypeptide binding]; other site
331272018459	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
331272018460	NAD(P) binding site [chemical binding]; other site
331272018461	catalytic residues [active]
331272018462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018464	WHG domain; Region: WHG; pfam13305
331272018465	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
331272018466	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
331272018467	potential catalytic triad [active]
331272018468	conserved cys residue [active]
331272018469	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
331272018470	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
331272018471	DNA binding residues [nucleotide binding]
331272018472	Uncharacterized conserved protein [Function unknown]; Region: COG3268
331272018473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272018474	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
331272018475	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
331272018476	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
331272018477	DNA binding residues [nucleotide binding]
331272018478	putative dimer interface [polypeptide binding]; other site
331272018479	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272018480	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272018481	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
331272018482	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
331272018483	HAMP domain; Region: HAMP; pfam00672
331272018484	dimerization interface [polypeptide binding]; other site
331272018485	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272018486	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272018487	dimer interface [polypeptide binding]; other site
331272018488	putative CheW interface [polypeptide binding]; other site
331272018489	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331272018490	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
331272018491	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018493	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018494	dimerization interface [polypeptide binding]; other site
331272018495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018497	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272018498	putative effector binding pocket; other site
331272018499	putative dimerization interface [polypeptide binding]; other site
331272018500	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
331272018501	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272018502	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272018503	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272018504	active site
331272018505	catalytic tetrad [active]
331272018506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272018507	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272018508	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
331272018509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018511	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
331272018512	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
331272018513	Active site cavity [active]
331272018514	catalytic acid [active]
331272018515	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
331272018516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018517	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
331272018518	putative dimerization interface [polypeptide binding]; other site
331272018519	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272018520	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272018521	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
331272018522	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
331272018523	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272018524	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018525	substrate binding pocket [chemical binding]; other site
331272018526	membrane-bound complex binding site; other site
331272018527	hinge residues; other site
331272018528	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
331272018529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018530	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
331272018531	dimerization interface [polypeptide binding]; other site
331272018532	substrate binding pocket [chemical binding]; other site
331272018533	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
331272018534	putative hydrophobic ligand binding site [chemical binding]; other site
331272018535	protein interface [polypeptide binding]; other site
331272018536	gate; other site
331272018537	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272018538	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272018539	active site
331272018540	catalytic tetrad [active]
331272018541	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272018542	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272018543	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272018544	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272018545	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272018546	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
331272018547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018549	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018550	dimerization interface [polypeptide binding]; other site
331272018551	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272018552	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272018553	NAD(P) binding site [chemical binding]; other site
331272018554	active site
331272018555	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
331272018556	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
331272018557	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
331272018558	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
331272018559	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272018560	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272018561	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
331272018562	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
331272018563	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
331272018564	Uncharacterized conserved protein [Function unknown]; Region: COG5476
331272018565	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
331272018566	MlrC C-terminus; Region: MlrC_C; pfam07171
331272018567	allantoate amidohydrolase; Reviewed; Region: PRK12893
331272018568	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
331272018569	active site
331272018570	metal binding site [ion binding]; metal-binding site
331272018571	dimer interface [polypeptide binding]; other site
331272018572	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272018573	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272018574	Walker A/P-loop; other site
331272018575	ATP binding site [chemical binding]; other site
331272018576	Q-loop/lid; other site
331272018577	ABC transporter signature motif; other site
331272018578	Walker B; other site
331272018579	D-loop; other site
331272018580	H-loop/switch region; other site
331272018581	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272018582	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272018583	Walker A/P-loop; other site
331272018584	ATP binding site [chemical binding]; other site
331272018585	Q-loop/lid; other site
331272018586	ABC transporter signature motif; other site
331272018587	Walker B; other site
331272018588	D-loop; other site
331272018589	H-loop/switch region; other site
331272018590	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272018591	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272018592	TM-ABC transporter signature motif; other site
331272018593	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272018594	TM-ABC transporter signature motif; other site
331272018595	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
331272018596	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
331272018597	putative ligand binding site [chemical binding]; other site
331272018598	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272018599	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272018600	DNA-binding site [nucleotide binding]; DNA binding site
331272018601	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272018602	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
331272018603	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272018604	NAD binding site [chemical binding]; other site
331272018605	catalytic residues [active]
331272018606	hypothetical protein; Provisional; Region: PRK06541
331272018607	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272018608	inhibitor-cofactor binding pocket; inhibition site
331272018609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018610	catalytic residue [active]
331272018611	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331272018612	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272018613	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272018614	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018615	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272018616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272018617	dimer interface [polypeptide binding]; other site
331272018618	conserved gate region; other site
331272018619	putative PBP binding loops; other site
331272018620	ABC-ATPase subunit interface; other site
331272018621	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
331272018622	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
331272018623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272018624	dimer interface [polypeptide binding]; other site
331272018625	conserved gate region; other site
331272018626	putative PBP binding loops; other site
331272018627	ABC-ATPase subunit interface; other site
331272018628	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
331272018629	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
331272018630	Walker A/P-loop; other site
331272018631	ATP binding site [chemical binding]; other site
331272018632	Q-loop/lid; other site
331272018633	ABC transporter signature motif; other site
331272018634	Walker B; other site
331272018635	D-loop; other site
331272018636	H-loop/switch region; other site
331272018637	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
331272018638	FOG: CBS domain [General function prediction only]; Region: COG0517
331272018639	Predicted transcriptional regulator [Transcription]; Region: COG3355
331272018640	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272018641	putative DNA binding site [nucleotide binding]; other site
331272018642	putative Zn2+ binding site [ion binding]; other site
331272018643	MarR family; Region: MarR_2; cl17246
331272018644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272018645	Coenzyme A binding pocket [chemical binding]; other site
331272018646	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
331272018647	benzoate transport; Region: 2A0115; TIGR00895
331272018648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018649	putative substrate translocation pore; other site
331272018650	H-NS histone family; Region: Histone_HNS; pfam00816
331272018651	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272018652	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
331272018653	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
331272018654	putative active site [active]
331272018655	putative NTP binding site [chemical binding]; other site
331272018656	putative nucleic acid binding site [nucleotide binding]; other site
331272018657	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
331272018658	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272018659	DNA-binding site [nucleotide binding]; DNA binding site
331272018660	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
331272018661	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
331272018662	active sites [active]
331272018663	tetramer interface [polypeptide binding]; other site
331272018664	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
331272018665	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272018666	Walker A/P-loop; other site
331272018667	ATP binding site [chemical binding]; other site
331272018668	Q-loop/lid; other site
331272018669	ABC transporter signature motif; other site
331272018670	Walker B; other site
331272018671	D-loop; other site
331272018672	H-loop/switch region; other site
331272018673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272018674	dimer interface [polypeptide binding]; other site
331272018675	conserved gate region; other site
331272018676	putative PBP binding loops; other site
331272018677	ABC-ATPase subunit interface; other site
331272018678	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272018679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272018680	dimer interface [polypeptide binding]; other site
331272018681	conserved gate region; other site
331272018682	putative PBP binding loops; other site
331272018683	ABC-ATPase subunit interface; other site
331272018684	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
331272018685	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018686	substrate binding pocket [chemical binding]; other site
331272018687	membrane-bound complex binding site; other site
331272018688	hinge residues; other site
331272018689	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
331272018690	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
331272018691	NADP binding site [chemical binding]; other site
331272018692	active site
331272018693	putative substrate binding site [chemical binding]; other site
331272018694	Predicted membrane protein [Function unknown]; Region: COG2259
331272018695	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
331272018696	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
331272018697	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
331272018698	Nitrate and nitrite sensing; Region: NIT; pfam08376
331272018699	ANTAR domain; Region: ANTAR; pfam03861
331272018700	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
331272018701	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272018702	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272018703	inhibitor site; inhibition site
331272018704	active site
331272018705	dimer interface [polypeptide binding]; other site
331272018706	catalytic residue [active]
331272018707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018708	D-galactonate transporter; Region: 2A0114; TIGR00893
331272018709	putative substrate translocation pore; other site
331272018710	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272018711	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
331272018712	substrate binding site [chemical binding]; other site
331272018713	dimer interface [polypeptide binding]; other site
331272018714	ATP binding site [chemical binding]; other site
331272018715	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272018716	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272018717	DNA binding site [nucleotide binding]
331272018718	domain linker motif; other site
331272018719	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
331272018720	putative dimerization interface [polypeptide binding]; other site
331272018721	putative ligand binding site [chemical binding]; other site
331272018722	Fic family protein [Function unknown]; Region: COG3177
331272018723	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
331272018724	Fic/DOC family; Region: Fic; pfam02661
331272018725	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
331272018726	LysR family transcriptional regulator; Provisional; Region: PRK14997
331272018727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018728	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272018729	putative effector binding pocket; other site
331272018730	dimerization interface [polypeptide binding]; other site
331272018731	Pirin-related protein [General function prediction only]; Region: COG1741
331272018732	Pirin; Region: Pirin; pfam02678
331272018733	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
331272018734	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272018735	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
331272018736	LrgA family; Region: LrgA; pfam03788
331272018737	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
331272018738	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
331272018739	substrate binding pocket [chemical binding]; other site
331272018740	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272018741	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
331272018742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018743	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018744	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018745	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018746	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
331272018747	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
331272018748	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272018749	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
331272018750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272018751	Walker A/P-loop; other site
331272018752	ATP binding site [chemical binding]; other site
331272018753	Q-loop/lid; other site
331272018754	ABC transporter signature motif; other site
331272018755	Walker B; other site
331272018756	D-loop; other site
331272018757	H-loop/switch region; other site
331272018758	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272018759	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272018760	trimer interface [polypeptide binding]; other site
331272018761	eyelet of channel; other site
331272018762	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
331272018763	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
331272018764	putative C-terminal domain interface [polypeptide binding]; other site
331272018765	putative GSH binding site (G-site) [chemical binding]; other site
331272018766	putative dimer interface [polypeptide binding]; other site
331272018767	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
331272018768	putative N-terminal domain interface [polypeptide binding]; other site
331272018769	putative dimer interface [polypeptide binding]; other site
331272018770	putative substrate binding pocket (H-site) [chemical binding]; other site
331272018771	Acyltransferase family; Region: Acyl_transf_3; pfam01757
331272018772	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018774	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018775	dimerization interface [polypeptide binding]; other site
331272018776	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
331272018777	EamA-like transporter family; Region: EamA; pfam00892
331272018778	EamA-like transporter family; Region: EamA; pfam00892
331272018779	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272018780	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272018781	dimerization interface [polypeptide binding]; other site
331272018782	ligand binding site [chemical binding]; other site
331272018783	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
331272018784	FAD binding domain; Region: FAD_binding_4; pfam01565
331272018785	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
331272018786	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018788	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272018789	dimerization interface [polypeptide binding]; other site
331272018790	substrate binding pocket [chemical binding]; other site
331272018791	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018793	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018794	dimerization interface [polypeptide binding]; other site
331272018795	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272018796	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
331272018797	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
331272018798	active site
331272018799	dimer interface [polypeptide binding]; other site
331272018800	non-prolyl cis peptide bond; other site
331272018801	insertion regions; other site
331272018802	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272018803	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
331272018804	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
331272018805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272018806	Walker A motif; other site
331272018807	ATP binding site [chemical binding]; other site
331272018808	Walker B motif; other site
331272018809	arginine finger; other site
331272018810	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
331272018811	dihydroxyacetone kinase; Provisional; Region: PRK14479
331272018812	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
331272018813	DAK2 domain; Region: Dak2; pfam02734
331272018814	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
331272018815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272018816	metabolite-proton symporter; Region: 2A0106; TIGR00883
331272018817	putative substrate translocation pore; other site
331272018818	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272018819	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
331272018820	DNA-binding site [nucleotide binding]; DNA binding site
331272018821	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272018822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018823	homodimer interface [polypeptide binding]; other site
331272018824	catalytic residue [active]
331272018825	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
331272018826	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
331272018827	hypothetical protein; Provisional; Region: PRK07482
331272018828	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272018829	inhibitor-cofactor binding pocket; inhibition site
331272018830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018831	catalytic residue [active]
331272018832	succinic semialdehyde dehydrogenase; Region: PLN02278
331272018833	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331272018834	tetramerization interface [polypeptide binding]; other site
331272018835	NAD(P) binding site [chemical binding]; other site
331272018836	catalytic residues [active]
331272018837	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272018838	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272018839	putative DNA binding site [nucleotide binding]; other site
331272018840	putative Zn2+ binding site [ion binding]; other site
331272018841	AsnC family; Region: AsnC_trans_reg; pfam01037
331272018842	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
331272018843	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
331272018844	putative active site [active]
331272018845	Zn binding site [ion binding]; other site
331272018846	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
331272018847	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
331272018848	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
331272018849	active site
331272018850	ectoine utilization protein EutC; Validated; Region: PRK08291
331272018851	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
331272018852	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
331272018853	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
331272018854	tetramer interface [polypeptide binding]; other site
331272018855	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018856	catalytic residue [active]
331272018857	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272018858	DNA-binding site [nucleotide binding]; DNA binding site
331272018859	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272018860	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272018861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272018862	homodimer interface [polypeptide binding]; other site
331272018863	catalytic residue [active]
331272018864	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
331272018865	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
331272018866	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
331272018867	CoA-transferase family III; Region: CoA_transf_3; pfam02515
331272018868	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272018869	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272018870	active site
331272018871	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
331272018872	Uncharacterized conserved protein [Function unknown]; Region: COG3777
331272018873	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
331272018874	active site 2 [active]
331272018875	active site 1 [active]
331272018876	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
331272018877	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
331272018878	Fusaric acid resistance protein family; Region: FUSC; pfam04632
331272018879	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
331272018880	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
331272018881	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
331272018882	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272018883	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272018884	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272018885	TOBE domain; Region: TOBE; cl01440
331272018886	TOBE domain; Region: TOBE; cl01440
331272018887	NifQ; Region: NifQ; pfam04891
331272018888	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
331272018889	ProQ/FINO family; Region: ProQ; pfam04352
331272018890	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
331272018891	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
331272018892	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
331272018893	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272018894	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
331272018895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272018896	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272018897	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
331272018898	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
331272018899	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
331272018900	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272018901	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272018902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018903	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
331272018904	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272018905	P-loop; other site
331272018906	Magnesium ion binding site [ion binding]; other site
331272018907	ParB-like nuclease domain; Region: ParB; smart00470
331272018908	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
331272018909	Initiator Replication protein; Region: Rep_3; pfam01051
331272018910	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272018911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018912	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272018913	dimerization interface [polypeptide binding]; other site
331272018914	substrate binding pocket [chemical binding]; other site
331272018915	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
331272018916	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
331272018917	GDP-binding site [chemical binding]; other site
331272018918	ACT binding site; other site
331272018919	IMP binding site; other site
331272018920	transcriptional regulator; Provisional; Region: PRK10632
331272018921	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018922	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272018923	putative effector binding pocket; other site
331272018924	dimerization interface [polypeptide binding]; other site
331272018925	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272018926	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272018927	substrate binding pocket [chemical binding]; other site
331272018928	membrane-bound complex binding site; other site
331272018929	hinge residues; other site
331272018930	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272018931	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018932	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272018933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018934	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
331272018935	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018936	dimerization interface [polypeptide binding]; other site
331272018937	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
331272018938	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272018939	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272018940	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
331272018941	Protein export membrane protein; Region: SecD_SecF; cl14618
331272018942	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272018943	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
331272018944	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272018945	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272018946	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
331272018947	conserved cys residue [active]
331272018948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018949	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018950	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272018951	Zn2+ binding site [ion binding]; other site
331272018952	Mg2+ binding site [ion binding]; other site
331272018953	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
331272018954	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
331272018955	RES domain; Region: RES; pfam08808
331272018956	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331272018957	active site
331272018958	Int/Topo IB signature motif; other site
331272018959	catalytic residues [active]
331272018960	DNA binding site [nucleotide binding]
331272018961	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
331272018962	xanthine permease; Region: pbuX; TIGR03173
331272018963	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
331272018964	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272018965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272018966	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272018967	dimerization interface [polypeptide binding]; other site
331272018968	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
331272018969	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
331272018970	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
331272018971	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
331272018972	active site
331272018973	metal binding site [ion binding]; metal-binding site
331272018974	DNA binding site [nucleotide binding]
331272018975	P-loop containing region of AAA domain; Region: AAA_29; cl17516
331272018976	AAA domain; Region: AAA_27; pfam13514
331272018977	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
331272018978	HD domain; Region: HD_4; pfam13328
331272018979	Protein of unknown function (DUF429); Region: DUF429; pfam04250
331272018980	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272018981	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272018982	Coenzyme A binding pocket [chemical binding]; other site
331272018983	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272018984	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272018985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272018986	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
331272018987	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973
331272018988	active site
331272018989	acyl-activating enzyme (AAE) consensus motif; other site
331272018990	putative CoA binding site [chemical binding]; other site
331272018991	AMP binding site [chemical binding]; other site
331272018992	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
331272018993	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
331272018994	NAD binding site [chemical binding]; other site
331272018995	homodimer interface [polypeptide binding]; other site
331272018996	homotetramer interface [polypeptide binding]; other site
331272018997	active site
331272018998	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
331272018999	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272019000	dimer interface [polypeptide binding]; other site
331272019001	active site
331272019002	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
331272019003	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272019004	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
331272019005	allantoate amidohydrolase; Reviewed; Region: PRK09290
331272019006	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
331272019007	active site
331272019008	metal binding site [ion binding]; metal-binding site
331272019009	dimer interface [polypeptide binding]; other site
331272019010	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
331272019011	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272019012	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
331272019013	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
331272019014	homodimer interface [polypeptide binding]; other site
331272019015	active site
331272019016	FMN binding site [chemical binding]; other site
331272019017	substrate binding site [chemical binding]; other site
331272019018	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
331272019019	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
331272019020	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
331272019021	Na binding site [ion binding]; other site
331272019022	putative substrate binding site [chemical binding]; other site
331272019023	phenylhydantoinase; Validated; Region: PRK08323
331272019024	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
331272019025	tetramer interface [polypeptide binding]; other site
331272019026	active site
331272019027	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
331272019028	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
331272019029	Nucleoside recognition; Region: Gate; pfam07670
331272019030	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
331272019031	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
331272019032	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
331272019033	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
331272019034	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
331272019035	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
331272019036	active site
331272019037	catalytic motif [active]
331272019038	Zn binding site [ion binding]; other site
331272019039	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272019040	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272019041	[2Fe-2S] cluster binding site [ion binding]; other site
331272019042	methionine sulfoxide reductase A; Provisional; Region: PRK13014
331272019043	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
331272019044	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
331272019045	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
331272019046	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
331272019047	catalytic residues [active]
331272019048	methionine sulfoxide reductase B; Provisional; Region: PRK00222
331272019049	SelR domain; Region: SelR; pfam01641
331272019050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019052	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272019053	putative effector binding pocket; other site
331272019054	putative dimerization interface [polypeptide binding]; other site
331272019055	short chain dehydrogenase; Provisional; Region: PRK09291
331272019056	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272019057	NADP binding site [chemical binding]; other site
331272019058	active site
331272019059	steroid binding site; other site
331272019060	Domain of unknown function (DUF336); Region: DUF336; cl01249
331272019061	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
331272019062	oligomerisation interface [polypeptide binding]; other site
331272019063	mobile loop; other site
331272019064	roof hairpin; other site
331272019065	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
331272019066	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
331272019067	ring oligomerisation interface [polypeptide binding]; other site
331272019068	ATP/Mg binding site [chemical binding]; other site
331272019069	stacking interactions; other site
331272019070	hinge regions; other site
331272019071	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
331272019072	dimanganese center [ion binding]; other site
331272019073	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
331272019074	CheB methylesterase; Region: CheB_methylest; pfam01339
331272019075	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
331272019076	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
331272019077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272019078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272019079	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272019080	Sel1-like repeats; Region: SEL1; smart00671
331272019081	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
331272019082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272019085	dimerization interface [polypeptide binding]; other site
331272019086	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272019087	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272019088	inhibitor site; inhibition site
331272019089	active site
331272019090	dimer interface [polypeptide binding]; other site
331272019091	catalytic residue [active]
331272019092	benzoate transport; Region: 2A0115; TIGR00895
331272019093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019094	putative substrate translocation pore; other site
331272019095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019096	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272019097	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272019098	trimer interface [polypeptide binding]; other site
331272019099	eyelet of channel; other site
331272019100	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
331272019101	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
331272019102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272019103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272019104	metal binding site [ion binding]; metal-binding site
331272019105	active site
331272019106	I-site; other site
331272019107	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
331272019108	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272019109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019110	active site
331272019111	phosphorylation site [posttranslational modification]
331272019112	intermolecular recognition site; other site
331272019113	dimerization interface [polypeptide binding]; other site
331272019114	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272019115	DNA binding site [nucleotide binding]
331272019116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272019117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272019118	dimer interface [polypeptide binding]; other site
331272019119	phosphorylation site [posttranslational modification]
331272019120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272019121	ATP binding site [chemical binding]; other site
331272019122	Mg2+ binding site [ion binding]; other site
331272019123	G-X-G motif; other site
331272019124	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272019125	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272019126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019127	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
331272019128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
331272019129	active site
331272019130	motif I; other site
331272019131	motif II; other site
331272019132	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
331272019133	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
331272019134	acyl-activating enzyme (AAE) consensus motif; other site
331272019135	putative AMP binding site [chemical binding]; other site
331272019136	putative active site [active]
331272019137	putative CoA binding site [chemical binding]; other site
331272019138	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
331272019139	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272019140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019141	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
331272019142	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
331272019143	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272019144	active site
331272019145	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
331272019146	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
331272019147	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
331272019148	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
331272019149	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
331272019150	beta-ketothiolase; Provisional; Region: PRK09051
331272019151	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
331272019152	dimer interface [polypeptide binding]; other site
331272019153	active site
331272019154	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
331272019155	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
331272019156	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
331272019157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272019158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272019159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272019160	NADH(P)-binding; Region: NAD_binding_10; pfam13460
331272019161	NAD(P) binding site [chemical binding]; other site
331272019162	active site
331272019163	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
331272019164	Cupin domain; Region: Cupin_2; cl17218
331272019165	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272019166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019168	EamA-like transporter family; Region: EamA; pfam00892
331272019169	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
331272019170	EamA-like transporter family; Region: EamA; pfam00892
331272019171	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
331272019172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019173	Walker A motif; other site
331272019174	ATP binding site [chemical binding]; other site
331272019175	Walker B motif; other site
331272019176	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
331272019177	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
331272019178	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
331272019179	intersubunit interface [polypeptide binding]; other site
331272019180	active site
331272019181	catalytic residue [active]
331272019182	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
331272019183	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
331272019184	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
331272019185	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
331272019186	active site
331272019187	catalytic residues [active]
331272019188	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
331272019189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019191	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
331272019192	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
331272019193	substrate binding site [chemical binding]; other site
331272019194	dimer interface [polypeptide binding]; other site
331272019195	ATP binding site [chemical binding]; other site
331272019196	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272019197	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272019198	inhibitor site; inhibition site
331272019199	active site
331272019200	dimer interface [polypeptide binding]; other site
331272019201	catalytic residue [active]
331272019202	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
331272019203	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
331272019204	putative active site [active]
331272019205	metal binding site [ion binding]; metal-binding site
331272019206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
331272019207	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
331272019208	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
331272019209	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
331272019210	Na binding site [ion binding]; other site
331272019211	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
331272019212	BNR repeat-like domain; Region: BNR_2; pfam13088
331272019213	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
331272019214	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
331272019215	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
331272019216	classical (c) SDRs; Region: SDR_c; cd05233
331272019217	NAD(P) binding site [chemical binding]; other site
331272019218	active site
331272019219	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331272019220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272019222	putative substrate translocation pore; other site
331272019223	Transposase domain (DUF772); Region: DUF772; pfam05598
331272019224	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
331272019225	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272019226	sequence-specific DNA binding site [nucleotide binding]; other site
331272019227	salt bridge; other site
331272019228	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
331272019229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272019230	dimer interface [polypeptide binding]; other site
331272019231	putative PBP binding loops; other site
331272019232	ABC-ATPase subunit interface; other site
331272019233	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
331272019234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272019235	dimer interface [polypeptide binding]; other site
331272019236	conserved gate region; other site
331272019237	putative PBP binding loops; other site
331272019238	ABC-ATPase subunit interface; other site
331272019239	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
331272019240	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
331272019241	Walker A/P-loop; other site
331272019242	ATP binding site [chemical binding]; other site
331272019243	Q-loop/lid; other site
331272019244	ABC transporter signature motif; other site
331272019245	Walker B; other site
331272019246	D-loop; other site
331272019247	H-loop/switch region; other site
331272019248	TOBE domain; Region: TOBE_2; pfam08402
331272019249	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
331272019250	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
331272019251	active site
331272019252	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272019253	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272019254	DNA binding site [nucleotide binding]
331272019255	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
331272019256	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
331272019257	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272019258	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
331272019259	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272019260	PYR/PP interface [polypeptide binding]; other site
331272019261	dimer interface [polypeptide binding]; other site
331272019262	TPP binding site [chemical binding]; other site
331272019263	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272019264	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
331272019265	TPP-binding site [chemical binding]; other site
331272019266	Trehalose utilisation; Region: ThuA; pfam06283
331272019267	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
331272019268	histidinol dehydrogenase; Region: hisD; TIGR00069
331272019269	NAD binding site [chemical binding]; other site
331272019270	dimerization interface [polypeptide binding]; other site
331272019271	product binding site; other site
331272019272	substrate binding site [chemical binding]; other site
331272019273	zinc binding site [ion binding]; other site
331272019274	catalytic residues [active]
331272019275	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272019276	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272019277	trimer interface [polypeptide binding]; other site
331272019278	eyelet of channel; other site
331272019279	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
331272019280	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
331272019281	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
331272019282	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
331272019283	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
331272019284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019285	putative substrate translocation pore; other site
331272019286	YCII-related domain; Region: YCII; cl00999
331272019287	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
331272019288	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
331272019289	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272019290	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
331272019291	choline dehydrogenase; Validated; Region: PRK02106
331272019292	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
331272019293	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
331272019294	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
331272019295	conserved cys residue [active]
331272019296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019297	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
331272019298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019299	active site
331272019300	phosphorylation site [posttranslational modification]
331272019301	intermolecular recognition site; other site
331272019302	dimerization interface [polypeptide binding]; other site
331272019303	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272019304	DNA binding site [nucleotide binding]
331272019305	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
331272019306	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
331272019307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272019308	dimer interface [polypeptide binding]; other site
331272019309	phosphorylation site [posttranslational modification]
331272019310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272019311	ATP binding site [chemical binding]; other site
331272019312	Mg2+ binding site [ion binding]; other site
331272019313	G-X-G motif; other site
331272019314	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272019315	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272019316	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272019317	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272019318	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272019319	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272019320	L-asparagine permease; Provisional; Region: PRK15049
331272019321	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272019322	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272019323	substrate binding pocket [chemical binding]; other site
331272019324	membrane-bound complex binding site; other site
331272019325	hinge residues; other site
331272019326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272019327	dimer interface [polypeptide binding]; other site
331272019328	conserved gate region; other site
331272019329	putative PBP binding loops; other site
331272019330	ABC-ATPase subunit interface; other site
331272019331	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272019332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272019333	dimer interface [polypeptide binding]; other site
331272019334	conserved gate region; other site
331272019335	putative PBP binding loops; other site
331272019336	ABC-ATPase subunit interface; other site
331272019337	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272019338	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
331272019339	Walker A/P-loop; other site
331272019340	ATP binding site [chemical binding]; other site
331272019341	Q-loop/lid; other site
331272019342	ABC transporter signature motif; other site
331272019343	Walker B; other site
331272019344	D-loop; other site
331272019345	H-loop/switch region; other site
331272019346	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272019347	hypothetical protein; Provisional; Region: PRK07236
331272019348	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
331272019349	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272019350	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
331272019351	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
331272019352	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
331272019353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272019355	dimerization interface [polypeptide binding]; other site
331272019356	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
331272019357	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
331272019358	Isochorismatase family; Region: Isochorismatase; pfam00857
331272019359	catalytic triad [active]
331272019360	dimer interface [polypeptide binding]; other site
331272019361	conserved cis-peptide bond; other site
331272019362	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
331272019363	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
331272019364	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
331272019365	active site
331272019366	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
331272019367	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
331272019368	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019369	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019370	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272019371	putative effector binding pocket; other site
331272019372	dimerization interface [polypeptide binding]; other site
331272019373	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
331272019374	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272019375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019377	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272019378	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272019379	DNA binding site [nucleotide binding]
331272019380	AAA ATPase domain; Region: AAA_16; pfam13191
331272019381	Predicted ATPase [General function prediction only]; Region: COG3903
331272019382	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
331272019383	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
331272019384	active site
331272019385	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272019386	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272019387	FMN binding site [chemical binding]; other site
331272019388	active site
331272019389	substrate binding site [chemical binding]; other site
331272019390	catalytic residue [active]
331272019391	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272019392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019393	putative substrate translocation pore; other site
331272019394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019396	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
331272019397	putative effector binding pocket; other site
331272019398	putative dimerization interface [polypeptide binding]; other site
331272019399	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272019400	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272019401	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272019402	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272019403	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272019404	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272019405	catalytic loop [active]
331272019406	iron binding site [ion binding]; other site
331272019407	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272019408	Cytochrome c; Region: Cytochrom_C; pfam00034
331272019409	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272019410	Cytochrome c; Region: Cytochrom_C; pfam00034
331272019411	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
331272019412	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272019413	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272019414	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272019415	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272019416	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
331272019417	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272019418	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272019419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019420	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272019421	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272019422	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272019423	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
331272019424	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272019425	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272019426	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272019427	DNA binding site [nucleotide binding]
331272019428	Predicted ATPase [General function prediction only]; Region: COG3903
331272019429	Predicted membrane protein [Function unknown]; Region: COG2259
331272019430	Mechanosensitive ion channel; Region: MS_channel; pfam00924
331272019431	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
331272019432	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
331272019433	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
331272019434	ligand binding site [chemical binding]; other site
331272019435	flexible hinge region; other site
331272019436	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
331272019437	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019438	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272019439	dimerization interface [polypeptide binding]; other site
331272019440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019441	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272019442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019443	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
331272019444	active site
331272019445	catalytic residues [active]
331272019446	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
331272019447	Predicted transcriptional regulators [Transcription]; Region: COG1378
331272019448	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
331272019449	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
331272019450	C-terminal domain interface [polypeptide binding]; other site
331272019451	sugar binding site [chemical binding]; other site
331272019452	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
331272019453	homotrimer interaction site [polypeptide binding]; other site
331272019454	putative active site [active]
331272019455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019456	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272019457	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
331272019458	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272019459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019461	short chain dehydrogenase; Provisional; Region: PRK06180
331272019462	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272019463	NADP binding site [chemical binding]; other site
331272019464	active site
331272019465	steroid binding site; other site
331272019466	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
331272019467	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272019468	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
331272019469	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272019470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
331272019472	dimerization interface [polypeptide binding]; other site
331272019473	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
331272019474	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272019475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272019476	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
331272019477	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
331272019478	Ligand Binding Site [chemical binding]; other site
331272019479	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
331272019480	Phage integrase protein; Region: DUF3701; pfam12482
331272019481	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
331272019482	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
331272019483	Int/Topo IB signature motif; other site
331272019484	TfoX N-terminal domain; Region: TfoX_N; pfam04993
331272019485	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272019486	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
331272019487	dimerization interface [polypeptide binding]; other site
331272019488	ligand binding site [chemical binding]; other site
331272019489	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272019490	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
331272019491	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272019492	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272019493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272019494	DNA-binding site [nucleotide binding]; DNA binding site
331272019495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272019496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272019497	homodimer interface [polypeptide binding]; other site
331272019498	catalytic residue [active]
331272019499	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272019500	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272019501	DNA-binding site [nucleotide binding]; DNA binding site
331272019502	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272019503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272019504	homodimer interface [polypeptide binding]; other site
331272019505	catalytic residue [active]
331272019506	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272019507	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019508	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272019509	dimerization interface [polypeptide binding]; other site
331272019510	substrate binding pocket [chemical binding]; other site
331272019511	hypothetical protein; Provisional; Region: PRK06062
331272019512	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272019513	inhibitor-cofactor binding pocket; inhibition site
331272019514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272019515	catalytic residue [active]
331272019516	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
331272019517	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
331272019518	substrate binding site [chemical binding]; other site
331272019519	oxyanion hole (OAH) forming residues; other site
331272019520	trimer interface [polypeptide binding]; other site
331272019521	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
331272019522	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
331272019523	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
331272019524	acyl-activating enzyme (AAE) consensus motif; other site
331272019525	putative AMP binding site [chemical binding]; other site
331272019526	putative active site [active]
331272019527	putative CoA binding site [chemical binding]; other site
331272019528	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
331272019529	MoaE interaction surface [polypeptide binding]; other site
331272019530	MoeB interaction surface [polypeptide binding]; other site
331272019531	thiocarboxylated glycine; other site
331272019532	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
331272019533	MoaE homodimer interface [polypeptide binding]; other site
331272019534	MoaD interaction [polypeptide binding]; other site
331272019535	active site residues [active]
331272019536	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
331272019537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272019538	FeS/SAM binding site; other site
331272019539	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
331272019540	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
331272019541	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
331272019542	dimer interface [polypeptide binding]; other site
331272019543	putative functional site; other site
331272019544	putative MPT binding site; other site
331272019545	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
331272019546	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
331272019547	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
331272019548	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
331272019549	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
331272019550	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
331272019551	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272019552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019553	Zeta toxin; Region: Zeta_toxin; pfam06414
331272019554	Walker A motif; other site
331272019555	ATP binding site [chemical binding]; other site
331272019556	Walker B motif; other site
331272019557	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
331272019558	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
331272019559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
331272019560	FeS/SAM binding site; other site
331272019561	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
331272019562	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
331272019563	active site
331272019564	ATP binding site [chemical binding]; other site
331272019565	substrate binding site [chemical binding]; other site
331272019566	activation loop (A-loop); other site
331272019567	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
331272019568	AAA domain; Region: AAA_11; pfam13086
331272019569	Part of AAA domain; Region: AAA_19; pfam13245
331272019570	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
331272019571	AAA domain; Region: AAA_12; pfam13087
331272019572	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
331272019573	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
331272019574	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
331272019575	active site
331272019576	HIGH motif; other site
331272019577	dimer interface [polypeptide binding]; other site
331272019578	KMSKS motif; other site
331272019579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272019580	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272019581	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272019582	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272019583	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272019584	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272019585	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
331272019586	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272019587	putative active site [active]
331272019588	catalytic site [active]
331272019589	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272019590	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
331272019591	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
331272019592	putative active site [active]
331272019593	catalytic site [active]
331272019594	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
331272019595	Sel1-like repeats; Region: SEL1; smart00671
331272019596	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
331272019597	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
331272019598	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
331272019599	putative molybdopterin cofactor binding site [chemical binding]; other site
331272019600	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
331272019601	putative molybdopterin cofactor binding site; other site
331272019602	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
331272019603	Clp amino terminal domain; Region: Clp_N; pfam02861
331272019604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019605	Walker A motif; other site
331272019606	ATP binding site [chemical binding]; other site
331272019607	Walker B motif; other site
331272019608	arginine finger; other site
331272019609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019610	Walker A motif; other site
331272019611	ATP binding site [chemical binding]; other site
331272019612	Walker B motif; other site
331272019613	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
331272019614	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
331272019615	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
331272019616	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
331272019617	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
331272019618	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
331272019619	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272019620	DNA-binding site [nucleotide binding]; DNA binding site
331272019621	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272019622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272019623	homodimer interface [polypeptide binding]; other site
331272019624	catalytic residue [active]
331272019625	formate dehydrogenase; Provisional; Region: PRK07574
331272019626	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
331272019627	dimerization interface [polypeptide binding]; other site
331272019628	ligand binding site [chemical binding]; other site
331272019629	NAD binding site [chemical binding]; other site
331272019630	catalytic site [active]
331272019631	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
331272019632	[2Fe-2S] cluster binding site [ion binding]; other site
331272019633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
331272019634	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
331272019635	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
331272019636	MarC family integral membrane protein; Region: MarC; cl00919
331272019637	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
331272019638	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
331272019639	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272019640	NAD binding site [chemical binding]; other site
331272019641	catalytic Zn binding site [ion binding]; other site
331272019642	structural Zn binding site [ion binding]; other site
331272019643	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
331272019644	dimerization interface [polypeptide binding]; other site
331272019645	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331272019646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272019647	putative active site [active]
331272019648	heme pocket [chemical binding]; other site
331272019649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272019650	dimer interface [polypeptide binding]; other site
331272019651	phosphorylation site [posttranslational modification]
331272019652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272019653	ATP binding site [chemical binding]; other site
331272019654	Mg2+ binding site [ion binding]; other site
331272019655	G-X-G motif; other site
331272019656	Response regulator receiver domain; Region: Response_reg; pfam00072
331272019657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019658	active site
331272019659	phosphorylation site [posttranslational modification]
331272019660	intermolecular recognition site; other site
331272019661	dimerization interface [polypeptide binding]; other site
331272019662	BON domain; Region: BON; pfam04972
331272019663	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
331272019664	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
331272019665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272019666	Walker A/P-loop; other site
331272019667	ATP binding site [chemical binding]; other site
331272019668	Q-loop/lid; other site
331272019669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
331272019670	ABC transporter signature motif; other site
331272019671	Walker B; other site
331272019672	D-loop; other site
331272019673	H-loop/switch region; other site
331272019674	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
331272019675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019676	active site
331272019677	phosphorylation site [posttranslational modification]
331272019678	intermolecular recognition site; other site
331272019679	dimerization interface [polypeptide binding]; other site
331272019680	short chain dehydrogenase; Provisional; Region: PRK07326
331272019681	classical (c) SDRs; Region: SDR_c; cd05233
331272019682	NAD(P) binding site [chemical binding]; other site
331272019683	active site
331272019684	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
331272019685	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272019686	active site
331272019687	motif I; other site
331272019688	motif II; other site
331272019689	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272019690	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272019691	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272019692	putative active site [active]
331272019693	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
331272019694	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
331272019695	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
331272019696	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
331272019697	active site
331272019698	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
331272019699	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
331272019700	putative active site [active]
331272019701	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
331272019702	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
331272019703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019704	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
331272019705	Walker A motif; other site
331272019706	ATP binding site [chemical binding]; other site
331272019707	Walker B motif; other site
331272019708	arginine finger; other site
331272019709	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272019710	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272019711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019712	active site
331272019713	phosphorylation site [posttranslational modification]
331272019714	intermolecular recognition site; other site
331272019715	dimerization interface [polypeptide binding]; other site
331272019716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272019717	Walker A motif; other site
331272019718	ATP binding site [chemical binding]; other site
331272019719	Walker B motif; other site
331272019720	arginine finger; other site
331272019721	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272019722	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
331272019723	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
331272019724	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
331272019725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272019726	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
331272019727	putative active site [active]
331272019728	heme pocket [chemical binding]; other site
331272019729	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
331272019730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
331272019731	putative active site [active]
331272019732	heme pocket [chemical binding]; other site
331272019733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272019734	dimer interface [polypeptide binding]; other site
331272019735	phosphorylation site [posttranslational modification]
331272019736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272019737	ATP binding site [chemical binding]; other site
331272019738	Mg2+ binding site [ion binding]; other site
331272019739	G-X-G motif; other site
331272019740	Response regulator receiver domain; Region: Response_reg; pfam00072
331272019741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019742	active site
331272019743	phosphorylation site [posttranslational modification]
331272019744	intermolecular recognition site; other site
331272019745	dimerization interface [polypeptide binding]; other site
331272019746	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
331272019747	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
331272019748	NAD binding site [chemical binding]; other site
331272019749	putative substrate binding site 2 [chemical binding]; other site
331272019750	putative substrate binding site 1 [chemical binding]; other site
331272019751	active site
331272019752	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
331272019753	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
331272019754	putative ADP-binding pocket [chemical binding]; other site
331272019755	BON domain; Region: BON; pfam04972
331272019756	short chain dehydrogenase; Provisional; Region: PRK07109
331272019757	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
331272019758	putative NAD(P) binding site [chemical binding]; other site
331272019759	active site
331272019760	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
331272019761	short chain dehydrogenase; Provisional; Region: PRK06701
331272019762	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
331272019763	NAD binding site [chemical binding]; other site
331272019764	metal binding site [ion binding]; metal-binding site
331272019765	active site
331272019766	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
331272019767	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
331272019768	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
331272019769	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
331272019770	Fe-S cluster binding site [ion binding]; other site
331272019771	active site
331272019772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272019773	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
331272019774	active site
331272019775	phosphorylation site [posttranslational modification]
331272019776	intermolecular recognition site; other site
331272019777	dimerization interface [polypeptide binding]; other site
331272019778	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
331272019779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019780	putative substrate translocation pore; other site
331272019781	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
331272019782	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019784	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
331272019785	putative effector binding pocket; other site
331272019786	putative dimerization interface [polypeptide binding]; other site
331272019787	PRC-barrel domain; Region: PRC; pfam05239
331272019788	FOG: CBS domain [General function prediction only]; Region: COG0517
331272019789	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
331272019790	Domain of unknown function (DUF892); Region: DUF892; pfam05974
331272019791	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
331272019792	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
331272019793	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
331272019794	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
331272019795	hydroperoxidase II; Provisional; Region: katE; PRK11249
331272019796	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
331272019797	heme binding pocket [chemical binding]; other site
331272019798	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
331272019799	domain interactions; other site
331272019800	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
331272019801	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
331272019802	putative DNA binding site [nucleotide binding]; other site
331272019803	putative homodimer interface [polypeptide binding]; other site
331272019804	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
331272019805	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
331272019806	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
331272019807	active site
331272019808	DNA binding site [nucleotide binding]
331272019809	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
331272019810	DNA binding site [nucleotide binding]
331272019811	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
331272019812	nucleotide binding site [chemical binding]; other site
331272019813	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
331272019814	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
331272019815	intracellular protease, PfpI family; Region: PfpI; TIGR01382
331272019816	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
331272019817	proposed catalytic triad [active]
331272019818	conserved cys residue [active]
331272019819	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
331272019820	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
331272019821	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
331272019822	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
331272019823	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
331272019824	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
331272019825	active site
331272019826	catalytic site [active]
331272019827	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
331272019828	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
331272019829	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
331272019830	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
331272019831	active site
331272019832	catalytic site [active]
331272019833	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
331272019834	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
331272019835	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
331272019836	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
331272019837	active site
331272019838	catalytic site [active]
331272019839	glycogen branching enzyme; Provisional; Region: PRK05402
331272019840	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
331272019841	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
331272019842	active site
331272019843	catalytic site [active]
331272019844	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
331272019845	trehalose synthase; Region: treS_nterm; TIGR02456
331272019846	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
331272019847	active site
331272019848	catalytic site [active]
331272019849	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
331272019850	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
331272019851	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
331272019852	active site
331272019853	catalytic site [active]
331272019854	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
331272019855	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
331272019856	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
331272019857	active site
331272019858	homodimer interface [polypeptide binding]; other site
331272019859	catalytic site [active]
331272019860	acceptor binding site [chemical binding]; other site
331272019861	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
331272019862	putative catalytic site [active]
331272019863	putative metal binding site [ion binding]; other site
331272019864	putative phosphate binding site [ion binding]; other site
331272019865	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
331272019866	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
331272019867	putative active site [active]
331272019868	catalytic site [active]
331272019869	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
331272019870	putative active site [active]
331272019871	catalytic site [active]
331272019872	Uncharacterized conserved protein [Function unknown]; Region: COG0398
331272019873	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
331272019874	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
331272019875	MgtC family; Region: MgtC; pfam02308
331272019876	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575
331272019877	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
331272019878	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
331272019879	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
331272019880	[2Fe-2S] cluster binding site [ion binding]; other site
331272019881	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
331272019882	iron-sulfur cluster [ion binding]; other site
331272019883	[2Fe-2S] cluster binding site [ion binding]; other site
331272019884	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
331272019885	substrate binding pocket [chemical binding]; other site
331272019886	substrate-Mg2+ binding site; other site
331272019887	aspartate-rich region 1; other site
331272019888	aspartate-rich region 2; other site
331272019889	Methyltransferase domain; Region: Methyltransf_31; pfam13847
331272019890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
331272019891	S-adenosylmethionine binding site [chemical binding]; other site
331272019892	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
331272019893	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
331272019894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272019895	motif II; other site
331272019896	putative arabinose transporter; Provisional; Region: PRK03545
331272019897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272019898	putative substrate translocation pore; other site
331272019899	short chain dehydrogenase; Provisional; Region: PRK06172
331272019900	classical (c) SDRs; Region: SDR_c; cd05233
331272019901	NAD(P) binding site [chemical binding]; other site
331272019902	active site
331272019903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272019904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272019905	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272019906	putative effector binding pocket; other site
331272019907	dimerization interface [polypeptide binding]; other site
331272019908	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
331272019909	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
331272019910	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
331272019911	catalytic Zn binding site [ion binding]; other site
331272019912	NAD binding site [chemical binding]; other site
331272019913	structural Zn binding site [ion binding]; other site
331272019914	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272019915	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
331272019916	NAD(P) binding site [chemical binding]; other site
331272019917	catalytic residues [active]
331272019918	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
331272019919	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
331272019920	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
331272019921	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272019922	DNA binding site [nucleotide binding]
331272019923	AAA ATPase domain; Region: AAA_16; pfam13191
331272019924	Predicted ATPase [General function prediction only]; Region: COG3903
331272019925	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
331272019926	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
331272019927	dimer interface [polypeptide binding]; other site
331272019928	active site
331272019929	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
331272019930	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
331272019931	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
331272019932	putative alpha subunit interface [polypeptide binding]; other site
331272019933	putative active site [active]
331272019934	putative substrate binding site [chemical binding]; other site
331272019935	Fe binding site [ion binding]; other site
331272019936	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
331272019937	inter-subunit interface; other site
331272019938	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
331272019939	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272019940	catalytic loop [active]
331272019941	iron binding site [ion binding]; other site
331272019942	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
331272019943	FAD binding pocket [chemical binding]; other site
331272019944	FAD binding motif [chemical binding]; other site
331272019945	phosphate binding motif [ion binding]; other site
331272019946	beta-alpha-beta structure motif; other site
331272019947	NAD binding pocket [chemical binding]; other site
331272019948	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
331272019949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272019950	NAD(P) binding site [chemical binding]; other site
331272019951	active site
331272019952	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
331272019953	homotrimer interaction site [polypeptide binding]; other site
331272019954	putative active site [active]
331272019955	Tannase and feruloyl esterase; Region: Tannase; pfam07519
331272019956	Tannase and feruloyl esterase; Region: Tannase; pfam07519
331272019957	short chain dehydrogenase; Provisional; Region: PRK06179
331272019958	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
331272019959	NADP binding site [chemical binding]; other site
331272019960	active site
331272019961	steroid binding site; other site
331272019962	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
331272019963	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
331272019964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272019965	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272019966	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272019967	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272019968	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272019969	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
331272019970	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272019971	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
331272019972	Cytochrome c; Region: Cytochrom_C; pfam00034
331272019973	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
331272019974	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
331272019975	D-pathway; other site
331272019976	Putative ubiquinol binding site [chemical binding]; other site
331272019977	Low-spin heme (heme b) binding site [chemical binding]; other site
331272019978	Putative water exit pathway; other site
331272019979	Binuclear center (heme o3/CuB) [ion binding]; other site
331272019980	K-pathway; other site
331272019981	Putative proton exit pathway; other site
331272019982	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
331272019983	Subunit I/III interface [polypeptide binding]; other site
331272019984	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
331272019985	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
331272019986	Cytochrome c; Region: Cytochrom_C; pfam00034
331272019987	thiamine pyrophosphate protein; Provisional; Region: PRK08273
331272019988	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
331272019989	PYR/PP interface [polypeptide binding]; other site
331272019990	dimer interface [polypeptide binding]; other site
331272019991	tetramer interface [polypeptide binding]; other site
331272019992	TPP binding site [chemical binding]; other site
331272019993	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
331272019994	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
331272019995	TPP-binding site [chemical binding]; other site
331272019996	Domain of unknown function (DUF305); Region: DUF305; cl17794
331272019997	FRG domain; Region: FRG; pfam08867
331272019998	Low affinity iron permease; Region: Iron_permease; pfam04120
331272019999	BON domain; Region: BON; pfam04972
331272020000	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
331272020001	nudix motif; other site
331272020002	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
331272020003	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
331272020004	HlyD family secretion protein; Region: HlyD_3; pfam13437
331272020005	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272020006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020007	putative substrate translocation pore; other site
331272020008	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
331272020009	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
331272020010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272020011	active site
331272020012	phosphorylation site [posttranslational modification]
331272020013	intermolecular recognition site; other site
331272020014	dimerization interface [polypeptide binding]; other site
331272020015	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
331272020016	DNA binding site [nucleotide binding]
331272020017	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272020018	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
331272020019	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
331272020020	regulatory phosphorylation site [posttranslational modification]; other site
331272020021	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
331272020022	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
331272020023	PhnA protein; Region: PhnA; pfam03831
331272020024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
331272020025	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
331272020026	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
331272020027	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
331272020028	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
331272020029	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272020030	Walker A/P-loop; other site
331272020031	ATP binding site [chemical binding]; other site
331272020032	Q-loop/lid; other site
331272020033	ABC transporter signature motif; other site
331272020034	Walker B; other site
331272020035	D-loop; other site
331272020036	H-loop/switch region; other site
331272020037	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272020038	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272020039	Walker A/P-loop; other site
331272020040	ATP binding site [chemical binding]; other site
331272020041	Q-loop/lid; other site
331272020042	ABC transporter signature motif; other site
331272020043	Walker B; other site
331272020044	D-loop; other site
331272020045	H-loop/switch region; other site
331272020046	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272020047	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
331272020048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020049	dimer interface [polypeptide binding]; other site
331272020050	conserved gate region; other site
331272020051	putative PBP binding loops; other site
331272020052	ABC-ATPase subunit interface; other site
331272020053	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
331272020054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
331272020055	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
331272020056	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
331272020057	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272020058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272020059	Coenzyme A binding pocket [chemical binding]; other site
331272020060	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
331272020061	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272020062	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
331272020063	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
331272020064	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272020065	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272020066	substrate binding pocket [chemical binding]; other site
331272020067	membrane-bound complex binding site; other site
331272020068	hinge residues; other site
331272020069	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
331272020070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
331272020071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020072	putative PBP binding loops; other site
331272020073	dimer interface [polypeptide binding]; other site
331272020074	ABC-ATPase subunit interface; other site
331272020075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020076	dimer interface [polypeptide binding]; other site
331272020077	conserved gate region; other site
331272020078	putative PBP binding loops; other site
331272020079	ABC-ATPase subunit interface; other site
331272020080	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
331272020081	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
331272020082	active site
331272020083	non-prolyl cis peptide bond; other site
331272020084	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272020085	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272020086	Walker A/P-loop; other site
331272020087	ATP binding site [chemical binding]; other site
331272020088	Q-loop/lid; other site
331272020089	ABC transporter signature motif; other site
331272020090	Walker B; other site
331272020091	D-loop; other site
331272020092	H-loop/switch region; other site
331272020093	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272020094	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272020095	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272020096	TM-ABC transporter signature motif; other site
331272020097	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
331272020098	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272020099	putative ligand binding site [chemical binding]; other site
331272020100	OsmC-like protein; Region: OsmC; pfam02566
331272020101	Cupin; Region: Cupin_6; pfam12852
331272020102	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020103	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020105	oxidoreductase; Provisional; Region: PRK06196
331272020106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272020107	NAD(P) binding site [chemical binding]; other site
331272020108	active site
331272020109	HipA N-terminal domain; Region: Couple_hipA; pfam13657
331272020110	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
331272020111	HipA-like N-terminal domain; Region: HipA_N; pfam07805
331272020112	HipA-like C-terminal domain; Region: HipA_C; pfam07804
331272020113	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272020114	non-specific DNA binding site [nucleotide binding]; other site
331272020115	salt bridge; other site
331272020116	sequence-specific DNA binding site [nucleotide binding]; other site
331272020117	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
331272020118	FOG: CBS domain [General function prediction only]; Region: COG0517
331272020119	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
331272020120	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
331272020121	oxidoreductase; Provisional; Region: PRK06128
331272020122	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
331272020123	NAD binding site [chemical binding]; other site
331272020124	metal binding site [ion binding]; metal-binding site
331272020125	active site
331272020126	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
331272020127	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
331272020128	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272020129	NMT1-like family; Region: NMT1_2; pfam13379
331272020130	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272020131	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272020132	Walker A/P-loop; other site
331272020133	ATP binding site [chemical binding]; other site
331272020134	Q-loop/lid; other site
331272020135	ABC transporter signature motif; other site
331272020136	Walker B; other site
331272020137	D-loop; other site
331272020138	H-loop/switch region; other site
331272020139	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272020140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020141	dimer interface [polypeptide binding]; other site
331272020142	ABC-ATPase subunit interface; other site
331272020143	putative PBP binding loops; other site
331272020144	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
331272020145	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
331272020146	Flavin binding site [chemical binding]; other site
331272020147	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
331272020148	active site
331272020149	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
331272020150	dimer interface [polypeptide binding]; other site
331272020151	non-prolyl cis peptide bond; other site
331272020152	insertion regions; other site
331272020153	Cytochrome c; Region: Cytochrom_C; cl11414
331272020154	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
331272020155	Moco binding site; other site
331272020156	metal coordination site [ion binding]; other site
331272020157	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272020158	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272020159	trimer interface [polypeptide binding]; other site
331272020160	eyelet of channel; other site
331272020161	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
331272020162	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272020163	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272020164	substrate binding pocket [chemical binding]; other site
331272020165	membrane-bound complex binding site; other site
331272020166	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
331272020167	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
331272020168	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
331272020169	active site
331272020170	Zn binding site [ion binding]; other site
331272020171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272020172	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272020173	DNA-binding site [nucleotide binding]; DNA binding site
331272020174	FCD domain; Region: FCD; pfam07729
331272020175	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
331272020176	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272020177	Serine hydrolase; Region: Ser_hydrolase; cl17834
331272020178	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
331272020179	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
331272020180	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
331272020181	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
331272020182	active site
331272020183	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
331272020184	Phage integrase protein; Region: DUF3701; pfam12482
331272020185	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
331272020186	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272020187	active site
331272020188	DNA binding site [nucleotide binding]
331272020189	Int/Topo IB signature motif; other site
331272020190	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
331272020191	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
331272020192	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272020193	FCD domain; Region: FCD; pfam07729
331272020194	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
331272020195	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
331272020196	putative metal binding site [ion binding]; other site
331272020197	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
331272020198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
331272020199	Walker A/P-loop; other site
331272020200	ATP binding site [chemical binding]; other site
331272020201	Q-loop/lid; other site
331272020202	ABC transporter signature motif; other site
331272020203	Walker B; other site
331272020204	D-loop; other site
331272020205	H-loop/switch region; other site
331272020206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020207	dimer interface [polypeptide binding]; other site
331272020208	conserved gate region; other site
331272020209	putative PBP binding loops; other site
331272020210	ABC-ATPase subunit interface; other site
331272020211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020212	dimer interface [polypeptide binding]; other site
331272020213	conserved gate region; other site
331272020214	putative PBP binding loops; other site
331272020215	ABC-ATPase subunit interface; other site
331272020216	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
331272020217	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272020218	substrate binding pocket [chemical binding]; other site
331272020219	membrane-bound complex binding site; other site
331272020220	hinge residues; other site
331272020221	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
331272020222	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
331272020223	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272020224	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272020225	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272020226	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272020227	inhibitor site; inhibition site
331272020228	active site
331272020229	dimer interface [polypeptide binding]; other site
331272020230	catalytic residue [active]
331272020231	phenylhydantoinase; Validated; Region: PRK08323
331272020232	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
331272020233	tetramer interface [polypeptide binding]; other site
331272020234	active site
331272020235	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
331272020236	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
331272020237	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
331272020238	TPP-binding site [chemical binding]; other site
331272020239	dimer interface [polypeptide binding]; other site
331272020240	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331272020241	PYR/PP interface [polypeptide binding]; other site
331272020242	dimer interface [polypeptide binding]; other site
331272020243	TPP binding site [chemical binding]; other site
331272020244	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272020245	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272020246	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272020247	trimer interface [polypeptide binding]; other site
331272020248	eyelet of channel; other site
331272020249	benzoate transport; Region: 2A0115; TIGR00895
331272020250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020252	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
331272020253	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
331272020254	substrate binding site [chemical binding]; other site
331272020255	Protein of unknown function (DUF521); Region: DUF521; pfam04412
331272020256	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
331272020257	substrate binding site [chemical binding]; other site
331272020258	ligand binding site [chemical binding]; other site
331272020259	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
331272020260	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
331272020261	active site
331272020262	iron coordination sites [ion binding]; other site
331272020263	substrate binding pocket [chemical binding]; other site
331272020264	benzoate transport; Region: 2A0115; TIGR00895
331272020265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020266	putative substrate translocation pore; other site
331272020267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020268	Dehydratase family; Region: ILVD_EDD; pfam00920
331272020269	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
331272020270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272020271	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
331272020272	substrate binding pocket [chemical binding]; other site
331272020273	dimerization interface [polypeptide binding]; other site
331272020274	Predicted transcriptional regulators [Transcription]; Region: COG1733
331272020275	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
331272020276	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
331272020277	NmrA-like family; Region: NmrA; pfam05368
331272020278	NADP binding site [chemical binding]; other site
331272020279	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272020280	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272020281	Domain of unknown function (DUF718); Region: DUF718; pfam05336
331272020282	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272020283	classical (c) SDRs; Region: SDR_c; cd05233
331272020284	NAD(P) binding site [chemical binding]; other site
331272020285	active site
331272020286	L-rhamnonate dehydratase; Provisional; Region: PRK15440
331272020287	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
331272020288	putative active site pocket [active]
331272020289	putative metal binding site [ion binding]; other site
331272020290	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
331272020291	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
331272020292	inhibitor site; inhibition site
331272020293	active site
331272020294	dimer interface [polypeptide binding]; other site
331272020295	catalytic residue [active]
331272020296	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
331272020297	Ligand binding site; other site
331272020298	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
331272020299	Transcriptional regulators [Transcription]; Region: GntR; COG1802
331272020300	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272020301	DNA-binding site [nucleotide binding]; DNA binding site
331272020302	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
331272020303	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
331272020304	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
331272020305	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272020306	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
331272020307	homotrimer interaction site [polypeptide binding]; other site
331272020308	putative active site [active]
331272020309	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
331272020310	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
331272020311	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
331272020312	TM-ABC transporter signature motif; other site
331272020313	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
331272020314	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
331272020315	TM-ABC transporter signature motif; other site
331272020316	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
331272020317	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
331272020318	Walker A/P-loop; other site
331272020319	ATP binding site [chemical binding]; other site
331272020320	Q-loop/lid; other site
331272020321	ABC transporter signature motif; other site
331272020322	Walker B; other site
331272020323	D-loop; other site
331272020324	H-loop/switch region; other site
331272020325	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
331272020326	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
331272020327	Walker A/P-loop; other site
331272020328	ATP binding site [chemical binding]; other site
331272020329	Q-loop/lid; other site
331272020330	ABC transporter signature motif; other site
331272020331	Walker B; other site
331272020332	D-loop; other site
331272020333	H-loop/switch region; other site
331272020334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020335	putative substrate translocation pore; other site
331272020336	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
331272020337	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
331272020338	substrate binding site; other site
331272020339	tetramer interface; other site
331272020340	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
331272020341	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
331272020342	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
331272020343	NADP binding site [chemical binding]; other site
331272020344	active site
331272020345	putative substrate binding site [chemical binding]; other site
331272020346	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
331272020347	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
331272020348	NAD binding site [chemical binding]; other site
331272020349	substrate binding site [chemical binding]; other site
331272020350	homodimer interface [polypeptide binding]; other site
331272020351	active site
331272020352	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
331272020353	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
331272020354	putative dimer interface [polypeptide binding]; other site
331272020355	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
331272020356	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
331272020357	putative dimer interface [polypeptide binding]; other site
331272020358	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
331272020359	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
331272020360	PYR/PP interface [polypeptide binding]; other site
331272020361	dimer interface [polypeptide binding]; other site
331272020362	TPP binding site [chemical binding]; other site
331272020363	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
331272020364	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
331272020365	TPP-binding site [chemical binding]; other site
331272020366	dimer interface [polypeptide binding]; other site
331272020367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020368	D-galactonate transporter; Region: 2A0114; TIGR00893
331272020369	putative substrate translocation pore; other site
331272020370	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272020371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272020372	NAD(P) binding site [chemical binding]; other site
331272020373	active site
331272020374	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
331272020375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272020376	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
331272020377	dimerization interface [polypeptide binding]; other site
331272020378	substrate binding pocket [chemical binding]; other site
331272020379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272020380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272020381	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
331272020382	putative dimerization interface [polypeptide binding]; other site
331272020383	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
331272020384	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
331272020385	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
331272020386	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
331272020387	citrate-proton symporter; Provisional; Region: PRK15075
331272020388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020389	putative substrate translocation pore; other site
331272020390	Cache domain; Region: Cache_1; pfam02743
331272020391	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
331272020392	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
331272020393	metal binding site [ion binding]; metal-binding site
331272020394	active site
331272020395	I-site; other site
331272020396	Transcriptional regulator [Transcription]; Region: LysR; COG0583
331272020397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
331272020398	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
331272020399	putative effector binding pocket; other site
331272020400	dimerization interface [polypeptide binding]; other site
331272020401	NmrA-like family; Region: NmrA; pfam05368
331272020402	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
331272020403	NADP binding site [chemical binding]; other site
331272020404	active site
331272020405	regulatory binding site [polypeptide binding]; other site
331272020406	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
331272020407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272020408	Coenzyme A binding pocket [chemical binding]; other site
331272020409	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
331272020410	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
331272020411	metal binding site [ion binding]; metal-binding site
331272020412	putative dimer interface [polypeptide binding]; other site
331272020413	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
331272020414	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272020415	NAD binding site [chemical binding]; other site
331272020416	catalytic residues [active]
331272020417	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272020418	hydroxyglutarate oxidase; Provisional; Region: PRK11728
331272020419	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
331272020420	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020421	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020423	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
331272020424	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
331272020425	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
331272020426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272020427	Walker A/P-loop; other site
331272020428	ATP binding site [chemical binding]; other site
331272020429	Q-loop/lid; other site
331272020430	ABC transporter signature motif; other site
331272020431	Walker B; other site
331272020432	D-loop; other site
331272020433	H-loop/switch region; other site
331272020434	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
331272020435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
331272020436	Walker A/P-loop; other site
331272020437	ATP binding site [chemical binding]; other site
331272020438	Q-loop/lid; other site
331272020439	ABC transporter signature motif; other site
331272020440	Walker B; other site
331272020441	D-loop; other site
331272020442	H-loop/switch region; other site
331272020443	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
331272020444	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
331272020445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020446	dimer interface [polypeptide binding]; other site
331272020447	conserved gate region; other site
331272020448	ABC-ATPase subunit interface; other site
331272020449	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
331272020450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020451	dimer interface [polypeptide binding]; other site
331272020452	conserved gate region; other site
331272020453	putative PBP binding loops; other site
331272020454	ABC-ATPase subunit interface; other site
331272020455	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
331272020456	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
331272020457	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
331272020458	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272020459	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272020460	dimer interface [polypeptide binding]; other site
331272020461	putative CheW interface [polypeptide binding]; other site
331272020462	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
331272020463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
331272020464	motif II; other site
331272020465	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
331272020466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
331272020467	Coenzyme A binding pocket [chemical binding]; other site
331272020468	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
331272020469	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
331272020470	putative ligand binding site [chemical binding]; other site
331272020471	NAD binding site [chemical binding]; other site
331272020472	dimerization interface [polypeptide binding]; other site
331272020473	catalytic site [active]
331272020474	hypothetical protein; Provisional; Region: PRK05965
331272020475	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272020476	inhibitor-cofactor binding pocket; inhibition site
331272020477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272020478	catalytic residue [active]
331272020479	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
331272020480	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
331272020481	putative DNA binding site [nucleotide binding]; other site
331272020482	putative Zn2+ binding site [ion binding]; other site
331272020483	AsnC family; Region: AsnC_trans_reg; pfam01037
331272020484	succinic semialdehyde dehydrogenase; Region: PLN02278
331272020485	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331272020486	tetramerization interface [polypeptide binding]; other site
331272020487	NAD(P) binding site [chemical binding]; other site
331272020488	catalytic residues [active]
331272020489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272020490	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
331272020491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020492	EthD domain; Region: EthD; cl17553
331272020493	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
331272020494	Zn2+ binding site [ion binding]; other site
331272020495	Mg2+ binding site [ion binding]; other site
331272020496	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
331272020497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
331272020498	DNA binding residues [nucleotide binding]
331272020499	dimerization interface [polypeptide binding]; other site
331272020500	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
331272020501	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272020502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020503	putative substrate translocation pore; other site
331272020504	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272020505	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
331272020506	DNA binding site [nucleotide binding]
331272020507	domain linker motif; other site
331272020508	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
331272020509	putative dimerization interface [polypeptide binding]; other site
331272020510	putative ligand binding site [chemical binding]; other site
331272020511	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
331272020512	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
331272020513	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272020514	Cache domain; Region: Cache_1; pfam02743
331272020515	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272020516	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272020517	dimer interface [polypeptide binding]; other site
331272020518	putative CheW interface [polypeptide binding]; other site
331272020519	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
331272020520	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
331272020521	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
331272020522	dimer interface [polypeptide binding]; other site
331272020523	putative CheW interface [polypeptide binding]; other site
331272020524	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
331272020525	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
331272020526	active site
331272020527	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
331272020528	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
331272020529	galactarate dehydratase; Region: galactar-dH20; TIGR03248
331272020530	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
331272020531	altronate oxidoreductase; Provisional; Region: PRK03643
331272020532	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
331272020533	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
331272020534	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
331272020535	putative NAD(P) binding site [chemical binding]; other site
331272020536	catalytic Zn binding site [ion binding]; other site
331272020537	structural Zn binding site [ion binding]; other site
331272020538	Amidohydrolase; Region: Amidohydro_2; pfam04909
331272020539	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
331272020540	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
331272020541	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
331272020542	active site
331272020543	catalytic tetrad [active]
331272020544	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
331272020545	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
331272020546	putative ligand binding site [chemical binding]; other site
331272020547	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272020548	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272020549	TM-ABC transporter signature motif; other site
331272020550	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
331272020551	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272020552	Walker A/P-loop; other site
331272020553	ATP binding site [chemical binding]; other site
331272020554	Q-loop/lid; other site
331272020555	ABC transporter signature motif; other site
331272020556	Walker B; other site
331272020557	D-loop; other site
331272020558	H-loop/switch region; other site
331272020559	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272020560	Transcriptional regulators [Transcription]; Region: FadR; COG2186
331272020561	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
331272020562	DNA-binding site [nucleotide binding]; DNA binding site
331272020563	FCD domain; Region: FCD; pfam07729
331272020564	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
331272020565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020566	putative substrate translocation pore; other site
331272020567	Helix-turn-helix domain; Region: HTH_18; pfam12833
331272020568	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
331272020569	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331272020570	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
331272020571	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272020572	NAD(P) binding site [chemical binding]; other site
331272020573	catalytic residues [active]
331272020574	hypothetical protein; Provisional; Region: PRK07481
331272020575	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
331272020576	inhibitor-cofactor binding pocket; inhibition site
331272020577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272020578	catalytic residue [active]
331272020579	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
331272020580	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272020581	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272020582	trimer interface [polypeptide binding]; other site
331272020583	eyelet of channel; other site
331272020584	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
331272020585	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
331272020586	trimer interface [polypeptide binding]; other site
331272020587	eyelet of channel; other site
331272020588	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
331272020589	Transcriptional regulator [Transcription]; Region: IclR; COG1414
331272020590	Bacterial transcriptional regulator; Region: IclR; pfam01614
331272020591	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
331272020592	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
331272020593	tetramerization interface [polypeptide binding]; other site
331272020594	NAD(P) binding site [chemical binding]; other site
331272020595	catalytic residues [active]
331272020596	NIPSNAP; Region: NIPSNAP; pfam07978
331272020597	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
331272020598	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272020599	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
331272020600	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272020601	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272020602	Amino acid synthesis; Region: AA_synth; pfam06684
331272020603	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
331272020604	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272020605	putative active site [active]
331272020606	putative metal binding site [ion binding]; other site
331272020607	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
331272020608	Asp-box motif; other site
331272020609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
331272020610	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
331272020611	NAD(P) binding site [chemical binding]; other site
331272020612	active site
331272020613	hypothetical protein; Validated; Region: PRK07586
331272020614	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
331272020615	PYR/PP interface [polypeptide binding]; other site
331272020616	dimer interface [polypeptide binding]; other site
331272020617	TPP binding site [chemical binding]; other site
331272020618	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
331272020619	TPP-binding site [chemical binding]; other site
331272020620	dimer interface [polypeptide binding]; other site
331272020621	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
331272020622	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272020623	N-terminal plug; other site
331272020624	ligand-binding site [chemical binding]; other site
331272020625	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
331272020626	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
331272020627	transmembrane helices; other site
331272020628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020629	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272020630	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
331272020631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272020632	active site
331272020633	phosphorylation site [posttranslational modification]
331272020634	intermolecular recognition site; other site
331272020635	dimerization interface [polypeptide binding]; other site
331272020636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272020637	Walker A motif; other site
331272020638	ATP binding site [chemical binding]; other site
331272020639	Walker B motif; other site
331272020640	arginine finger; other site
331272020641	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
331272020642	dimer interface [polypeptide binding]; other site
331272020643	phosphorylation site [posttranslational modification]
331272020644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
331272020645	ATP binding site [chemical binding]; other site
331272020646	G-X-G motif; other site
331272020647	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272020648	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
331272020649	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
331272020650	TM-ABC transporter signature motif; other site
331272020651	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
331272020652	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
331272020653	Walker A/P-loop; other site
331272020654	ATP binding site [chemical binding]; other site
331272020655	Q-loop/lid; other site
331272020656	ABC transporter signature motif; other site
331272020657	Walker B; other site
331272020658	D-loop; other site
331272020659	H-loop/switch region; other site
331272020660	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
331272020661	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
331272020662	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
331272020663	putative ligand binding site [chemical binding]; other site
331272020664	xylulokinase; Provisional; Region: PRK15027
331272020665	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
331272020666	N- and C-terminal domain interface [polypeptide binding]; other site
331272020667	active site
331272020668	MgATP binding site [chemical binding]; other site
331272020669	catalytic site [active]
331272020670	metal binding site [ion binding]; metal-binding site
331272020671	xylulose binding site [chemical binding]; other site
331272020672	homodimer interface [polypeptide binding]; other site
331272020673	xylose isomerase; Provisional; Region: PRK05474
331272020674	xylose isomerase; Region: xylose_isom_A; TIGR02630
331272020675	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
331272020676	putative dimerization interface [polypeptide binding]; other site
331272020677	putative ligand binding site [chemical binding]; other site
331272020678	Transcriptional regulators [Transcription]; Region: PurR; COG1609
331272020679	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020680	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020681	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
331272020682	active site
331272020683	catalytic residues [active]
331272020684	Cupin; Region: Cupin_6; pfam12852
331272020685	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020687	Uncharacterized conserved protein [Function unknown]; Region: COG2128
331272020688	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
331272020689	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
331272020690	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272020691	active site
331272020692	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272020693	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272020694	Walker A/P-loop; other site
331272020695	ATP binding site [chemical binding]; other site
331272020696	Q-loop/lid; other site
331272020697	ABC transporter signature motif; other site
331272020698	Walker B; other site
331272020699	D-loop; other site
331272020700	H-loop/switch region; other site
331272020701	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
331272020702	NMT1-like family; Region: NMT1_2; pfam13379
331272020703	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272020704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020705	dimer interface [polypeptide binding]; other site
331272020706	conserved gate region; other site
331272020707	putative PBP binding loops; other site
331272020708	ABC-ATPase subunit interface; other site
331272020709	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
331272020710	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
331272020711	Flavin binding site [chemical binding]; other site
331272020712	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
331272020713	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
331272020714	active site
331272020715	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
331272020716	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
331272020717	active site
331272020718	non-prolyl cis peptide bond; other site
331272020719	benzoate transport; Region: 2A0115; TIGR00895
331272020720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272020721	putative substrate translocation pore; other site
331272020722	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
331272020723	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
331272020724	substrate binding pocket [chemical binding]; other site
331272020725	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
331272020726	membrane-bound complex binding site; other site
331272020727	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
331272020728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
331272020729	dimer interface [polypeptide binding]; other site
331272020730	conserved gate region; other site
331272020731	putative PBP binding loops; other site
331272020732	ABC-ATPase subunit interface; other site
331272020733	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
331272020734	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
331272020735	Walker A/P-loop; other site
331272020736	ATP binding site [chemical binding]; other site
331272020737	Q-loop/lid; other site
331272020738	ABC transporter signature motif; other site
331272020739	Walker B; other site
331272020740	D-loop; other site
331272020741	H-loop/switch region; other site
331272020742	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272020743	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272020744	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
331272020745	transcriptional regulator MerD; Provisional; Region: PRK13749
331272020746	DNA binding residues [nucleotide binding]
331272020747	putative dimer interface [polypeptide binding]; other site
331272020748	AAA domain; Region: AAA_17; pfam13207
331272020749	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
331272020750	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
331272020751	active site
331272020752	metal binding site [ion binding]; metal-binding site
331272020753	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
331272020754	trimer interface [polypeptide binding]; other site
331272020755	YadA-like C-terminal region; Region: YadA; pfam03895
331272020756	Response regulator receiver domain; Region: Response_reg; pfam00072
331272020757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
331272020758	active site
331272020759	phosphorylation site [posttranslational modification]
331272020760	intermolecular recognition site; other site
331272020761	dimerization interface [polypeptide binding]; other site
331272020762	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020763	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020764	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
331272020765	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
331272020766	N-terminal plug; other site
331272020767	ligand-binding site [chemical binding]; other site
331272020768	Protein of unknown function DUF72; Region: DUF72; pfam01904
331272020769	Autotransporter beta-domain; Region: Autotransporter; pfam03797
331272020770	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
331272020771	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
331272020772	catalytic loop [active]
331272020773	iron binding site [ion binding]; other site
331272020774	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
331272020775	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
331272020776	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
331272020777	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272020778	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
331272020779	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
331272020780	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272020781	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
331272020782	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
331272020783	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
331272020784	short chain dehydrogenase; Provisional; Region: PRK08265
331272020785	classical (c) SDRs; Region: SDR_c; cd05233
331272020786	NAD(P) binding site [chemical binding]; other site
331272020787	active site
331272020788	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
331272020789	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
331272020790	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
331272020791	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
331272020792	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272020793	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
331272020794	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
331272020795	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
331272020796	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
331272020797	ATP binding site [chemical binding]; other site
331272020798	Walker A motif; other site
331272020799	hexamer interface [polypeptide binding]; other site
331272020800	Walker B motif; other site
331272020801	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
331272020802	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
331272020803	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
331272020804	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
331272020805	TadE-like protein; Region: TadE; pfam07811
331272020806	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
331272020807	TadE-like protein; Region: TadE; pfam07811
331272020808	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
331272020809	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
331272020810	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
331272020811	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
331272020812	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
331272020813	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
331272020814	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
331272020815	active site
331272020816	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
331272020817	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
331272020818	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
331272020819	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
331272020820	N-acetyl-D-glucosamine binding site [chemical binding]; other site
331272020821	catalytic residue [active]
331272020822	TraE protein; Region: TraE; cl05060
331272020823	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
331272020824	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
331272020825	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
331272020826	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
331272020827	active site
331272020828	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
331272020829	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
331272020830	dimerization domain [polypeptide binding]; other site
331272020831	dimer interface [polypeptide binding]; other site
331272020832	catalytic residues [active]
331272020833	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
331272020834	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
331272020835	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
331272020836	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
331272020837	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
331272020838	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
331272020839	TraU protein; Region: TraU; pfam06834
331272020840	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
331272020841	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
331272020842	F plasmid transfer operon protein; Region: TraF; pfam13728
331272020843	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
331272020844	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
331272020845	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
331272020846	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
331272020847	PLD-like domain; Region: PLDc_2; pfam13091
331272020848	putative active site [active]
331272020849	catalytic site [active]
331272020850	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272020851	Zeta toxin; Region: Zeta_toxin; pfam06414
331272020852	Walker A motif; other site
331272020853	ATP binding site [chemical binding]; other site
331272020854	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
331272020855	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
331272020856	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272020857	trimer interface [polypeptide binding]; other site
331272020858	Haemagglutinin; Region: HIM; pfam05662
331272020859	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272020860	YadA-like C-terminal region; Region: YadA; pfam03895
331272020861	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
331272020862	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
331272020863	Uncharacterized conserved protein [Function unknown]; Region: COG4544
331272020864	DNA Polymerase Y-family; Region: PolY_like; cd03468
331272020865	DNA binding site [nucleotide binding]
331272020866	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
331272020867	PHP domain; Region: PHP; pfam02811
331272020868	putative active site [active]
331272020869	putative PHP Thumb interface [polypeptide binding]; other site
331272020870	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
331272020871	putative active site [active]
331272020872	PHP domain; Region: PHP; pfam02811
331272020873	putative PHP Thumb interface [polypeptide binding]; other site
331272020874	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
331272020875	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
331272020876	HTH-like domain; Region: HTH_21; pfam13276
331272020877	Integrase core domain; Region: rve; pfam00665
331272020878	Integrase core domain; Region: rve_3; pfam13683
331272020879	Transposase; Region: HTH_Tnp_1; cl17663
331272020880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272020881	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
331272020882	active site
331272020883	Int/Topo IB signature motif; other site
331272020884	catalytic residues [active]
331272020885	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
331272020886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272020887	Transposase; Region: HTH_Tnp_1; pfam01527
331272020888	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
331272020889	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
331272020890	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
331272020891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
331272020892	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
331272020893	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
331272020894	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
331272020895	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
331272020896	Integrase core domain; Region: rve; pfam00665
331272020897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
331272020898	Walker A motif; other site
331272020899	ATP binding site [chemical binding]; other site
331272020900	Walker B motif; other site
331272020901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272020902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272020903	WHG domain; Region: WHG; pfam13305
331272020904	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
331272020905	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
331272020906	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
331272020907	classical (c) SDRs; Region: SDR_c; cd05233
331272020908	NAD(P) binding site [chemical binding]; other site
331272020909	active site
331272020910	classical (c) SDRs; Region: SDR_c; cd05233
331272020911	NAD(P) binding site [chemical binding]; other site
331272020912	active site
331272020913	Homeodomain-like domain; Region: HTH_23; cl17451
331272020914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272020915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
331272020916	Integrase core domain; Region: rve; pfam00665
331272020917	Integrase core domain; Region: rve_3; pfam13683
331272020918	short chain dehydrogenase; Provisional; Region: PRK05872
331272020919	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
331272020920	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
331272020921	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
331272020922	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272020923	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272020924	FMN binding site [chemical binding]; other site
331272020925	active site
331272020926	substrate binding site [chemical binding]; other site
331272020927	catalytic residue [active]
331272020928	OsmC-like protein; Region: OsmC; pfam02566
331272020929	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331272020930	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
331272020931	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
331272020932	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
331272020933	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
331272020934	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
331272020935	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
331272020936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
331272020937	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
331272020938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
331272020939	Transposase; Region: HTH_Tnp_1; pfam01527
331272020940	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
331272020941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272020942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272020943	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
331272020944	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272020945	classical (c) SDRs; Region: SDR_c; cd05233
331272020946	NAD(P) binding site [chemical binding]; other site
331272020947	active site
331272020948	Phage integrase protein; Region: DUF3701; pfam12482
331272020949	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
331272020950	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
331272020951	Int/Topo IB signature motif; other site
331272020952	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
331272020953	YadA-like C-terminal region; Region: YadA; pfam03895
331272020954	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
331272020955	Uncharacterized conserved protein [Function unknown]; Region: COG4544
331272020956	DNA Polymerase Y-family; Region: PolY_like; cd03468
331272020957	DNA binding site [nucleotide binding]
331272020958	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
331272020959	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
331272020960	putative active site [active]
331272020961	putative PHP Thumb interface [polypeptide binding]; other site
331272020962	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
331272020963	generic binding surface II; other site
331272020964	generic binding surface I; other site
331272020965	Replication initiator protein A; Region: RPA; cl17860
331272020966	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
331272020967	ParA-like protein; Provisional; Region: PHA02518
331272020968	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
331272020969	P-loop; other site
331272020970	Magnesium ion binding site [ion binding]; other site
331272020971	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
331272020972	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
331272020973	active site
331272020974	DNA binding site [nucleotide binding]
331272020975	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
331272020976	DNA binding site [nucleotide binding]
331272020977	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
331272020978	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
331272020979	oligomeric interface; other site
331272020980	putative active site [active]
331272020981	homodimer interface [polypeptide binding]; other site
331272020982	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
331272020983	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
331272020984	non-specific DNA binding site [nucleotide binding]; other site
331272020985	salt bridge; other site
331272020986	sequence-specific DNA binding site [nucleotide binding]; other site
331272020987	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
331272020988	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
331272020989	active site
331272020990	catalytic site [active]
331272020991	substrate binding site [chemical binding]; other site
331272020992	Phage integrase protein; Region: DUF3701; pfam12482
331272020993	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272020994	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
331272020995	DNA binding site [nucleotide binding]
331272020996	Int/Topo IB signature motif; other site
331272020997	active site
331272020998	Divergent AAA domain; Region: AAA_4; pfam04326
331272020999	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
331272021000	FRG domain; Region: FRG; pfam08867
331272021001	H-NS histone family; Region: Histone_HNS; pfam00816
331272021002	PAAR motif; Region: PAAR_motif; pfam05488
331272021003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
331272021004	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
331272021005	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
331272021006	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
331272021007	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
331272021008	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
331272021009	active site
331272021010	catalytic site [active]
331272021011	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
331272021012	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
331272021013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
331272021014	homodimer interface [polypeptide binding]; other site
331272021015	catalytic residue [active]
331272021016	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
331272021017	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
331272021018	FMN binding site [chemical binding]; other site
331272021019	active site
331272021020	substrate binding site [chemical binding]; other site
331272021021	catalytic residue [active]
331272021022	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
331272021023	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
331272021024	catalytic residues [active]
331272021025	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
331272021026	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
331272021027	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
331272021028	OsmC-like protein; Region: OsmC; pfam02566
331272021029	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
331272021030	classical (c) SDRs; Region: SDR_c; cd05233
331272021031	NAD(P) binding site [chemical binding]; other site
331272021032	active site
331272021033	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
331272021034	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
331272021035	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
331272021036	Amidase; Region: Amidase; cl11426
331272021037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
331272021038	Major Facilitator Superfamily; Region: MFS_1; pfam07690
331272021039	putative substrate translocation pore; other site
331272021040	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
331272021041	transcriptional regulator EutR; Provisional; Region: PRK10130
331272021042	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
331272021043	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
331272021044	H-NS histone family; Region: Histone_HNS; pfam00816
331272021045	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
331272021046	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
331272021047	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
331272021048	Domain of unknown function (DUF932); Region: DUF932; pfam06067
331272021049	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
331272021050	DNA methylase; Region: N6_N4_Mtase; cl17433
331272021051	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
331272021052	ParB-like nuclease domain; Region: ParBc; pfam02195
331272021053	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
331272021054	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
331272021055	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
331272021056	F sex factor protein N terminal; Region: TraD_N; pfam12615
331272021057	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
331272021058	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
331272021059	Walker A motif; other site
331272021060	ATP binding site [chemical binding]; other site
331272021061	Walker B motif; other site
331272021062	TrwC relaxase; Region: TrwC; pfam08751
331272021063	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
331272021064	AAA domain; Region: AAA_30; pfam13604
331272021065	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
331272021066	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592