-- dump date 20140619_013251 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1009846000001 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1009846000002 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1009846000003 putative heme binding pocket [chemical binding]; other site 1009846000004 RNA polymerase sigma factor; Provisional; Region: PRK12511 1009846000005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846000006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846000007 DNA binding residues [nucleotide binding] 1009846000008 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1009846000009 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1009846000010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846000011 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1009846000012 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846000013 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1009846000014 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1009846000015 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1009846000016 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1009846000017 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1009846000018 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1009846000019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846000020 ATP binding site [chemical binding]; other site 1009846000021 putative Mg++ binding site [ion binding]; other site 1009846000022 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1009846000023 DNA methylase; Region: N6_N4_Mtase; pfam01555 1009846000024 DNA methylase; Region: N6_N4_Mtase; cl17433 1009846000025 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846000026 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846000027 trimer interface [polypeptide binding]; other site 1009846000028 eyelet of channel; other site 1009846000029 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1009846000030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000031 active site 1009846000032 phosphorylation site [posttranslational modification] 1009846000033 intermolecular recognition site; other site 1009846000034 dimerization interface [polypeptide binding]; other site 1009846000035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846000036 DNA binding site [nucleotide binding] 1009846000037 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1009846000038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846000039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846000040 dimer interface [polypeptide binding]; other site 1009846000041 phosphorylation site [posttranslational modification] 1009846000042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846000043 ATP binding site [chemical binding]; other site 1009846000044 Mg2+ binding site [ion binding]; other site 1009846000045 G-X-G motif; other site 1009846000046 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846000047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846000048 dimer interface [polypeptide binding]; other site 1009846000049 conserved gate region; other site 1009846000050 putative PBP binding loops; other site 1009846000051 ABC-ATPase subunit interface; other site 1009846000052 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009846000053 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846000054 Walker A/P-loop; other site 1009846000055 ATP binding site [chemical binding]; other site 1009846000056 Q-loop/lid; other site 1009846000057 ABC transporter signature motif; other site 1009846000058 Walker B; other site 1009846000059 D-loop; other site 1009846000060 H-loop/switch region; other site 1009846000061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1009846000062 NMT1/THI5 like; Region: NMT1; pfam09084 1009846000063 membrane-bound complex binding site; other site 1009846000064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846000065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000066 active site 1009846000067 phosphorylation site [posttranslational modification] 1009846000068 intermolecular recognition site; other site 1009846000069 dimerization interface [polypeptide binding]; other site 1009846000070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846000071 DNA binding residues [nucleotide binding] 1009846000072 dimerization interface [polypeptide binding]; other site 1009846000073 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846000074 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1009846000075 PapC N-terminal domain; Region: PapC_N; pfam13954 1009846000076 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846000077 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846000078 putative chaperone protein EcpD; Provisional; Region: PRK09926 1009846000079 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846000080 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1009846000081 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846000082 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1009846000083 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1009846000084 putative active site [active] 1009846000085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846000086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846000087 Walker A/P-loop; other site 1009846000088 ATP binding site [chemical binding]; other site 1009846000089 Q-loop/lid; other site 1009846000090 ABC transporter signature motif; other site 1009846000091 Walker B; other site 1009846000092 D-loop; other site 1009846000093 H-loop/switch region; other site 1009846000094 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1009846000095 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1009846000096 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846000097 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1009846000098 Cupin superfamily protein; Region: Cupin_4; pfam08007 1009846000099 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1009846000100 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1009846000101 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1009846000102 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1009846000103 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1009846000104 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1009846000105 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1009846000106 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1009846000107 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1009846000108 LrgA family; Region: LrgA; pfam03788 1009846000109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846000110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846000111 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1009846000112 putative dimerization interface [polypeptide binding]; other site 1009846000113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846000114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846000115 putative substrate translocation pore; other site 1009846000116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846000117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846000118 MarR family; Region: MarR_2; cl17246 1009846000119 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846000120 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1009846000121 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1009846000122 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1009846000123 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1009846000124 GspL periplasmic domain; Region: GspL_C; pfam12693 1009846000125 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1009846000126 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1009846000127 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1009846000128 Type II transport protein GspH; Region: GspH; pfam12019 1009846000129 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1009846000130 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1009846000131 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1009846000132 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1009846000133 type II secretion system protein F; Region: GspF; TIGR02120 1009846000134 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846000135 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846000136 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1009846000137 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1009846000138 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1009846000139 Walker A motif; other site 1009846000140 ATP binding site [chemical binding]; other site 1009846000141 Walker B motif; other site 1009846000142 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1009846000143 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1009846000144 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1009846000145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1009846000146 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1009846000147 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1009846000148 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846000149 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846000150 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846000151 catalytic residue [active] 1009846000152 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1009846000153 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1009846000154 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1009846000155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1009846000156 IHF dimer interface [polypeptide binding]; other site 1009846000157 IHF - DNA interface [nucleotide binding]; other site 1009846000158 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1009846000159 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1009846000160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846000161 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1009846000162 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1009846000163 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1009846000164 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1009846000165 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846000167 putative DNA binding site [nucleotide binding]; other site 1009846000168 putative Zn2+ binding site [ion binding]; other site 1009846000169 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1009846000170 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1009846000171 catalytic triad [active] 1009846000172 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846000173 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1009846000174 active site 1009846000175 FMN binding site [chemical binding]; other site 1009846000176 substrate binding site [chemical binding]; other site 1009846000177 homotetramer interface [polypeptide binding]; other site 1009846000178 catalytic residue [active] 1009846000179 Proteins containing SET domain [General function prediction only]; Region: COG2940 1009846000180 SET domain; Region: SET; pfam00856 1009846000181 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1009846000182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846000183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846000184 dimer interface [polypeptide binding]; other site 1009846000185 phosphorylation site [posttranslational modification] 1009846000186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846000187 ATP binding site [chemical binding]; other site 1009846000188 Mg2+ binding site [ion binding]; other site 1009846000189 G-X-G motif; other site 1009846000190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846000191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000192 active site 1009846000193 phosphorylation site [posttranslational modification] 1009846000194 intermolecular recognition site; other site 1009846000195 dimerization interface [polypeptide binding]; other site 1009846000196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846000197 DNA binding site [nucleotide binding] 1009846000198 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 1009846000199 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1009846000200 aromatic arch; other site 1009846000201 DCoH dimer interaction site [polypeptide binding]; other site 1009846000202 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1009846000203 DCoH tetramer interaction site [polypeptide binding]; other site 1009846000204 substrate binding site [chemical binding]; other site 1009846000205 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1009846000206 cofactor binding site; other site 1009846000207 metal binding site [ion binding]; metal-binding site 1009846000208 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846000209 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846000210 putative DNA binding site [nucleotide binding]; other site 1009846000211 putative Zn2+ binding site [ion binding]; other site 1009846000212 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846000213 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1009846000214 putative active site [active] 1009846000215 putative metal binding residues [ion binding]; other site 1009846000216 signature motif; other site 1009846000217 putative triphosphate binding site [ion binding]; other site 1009846000218 dimer interface [polypeptide binding]; other site 1009846000219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846000220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846000221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846000222 dimerization interface [polypeptide binding]; other site 1009846000223 choline dehydrogenase; Validated; Region: PRK02106 1009846000224 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1009846000225 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846000226 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846000227 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846000228 Walker A/P-loop; other site 1009846000229 ATP binding site [chemical binding]; other site 1009846000230 Q-loop/lid; other site 1009846000231 ABC transporter signature motif; other site 1009846000232 Walker B; other site 1009846000233 D-loop; other site 1009846000234 H-loop/switch region; other site 1009846000235 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846000236 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846000237 Walker A/P-loop; other site 1009846000238 ATP binding site [chemical binding]; other site 1009846000239 Q-loop/lid; other site 1009846000240 ABC transporter signature motif; other site 1009846000241 Walker B; other site 1009846000242 D-loop; other site 1009846000243 H-loop/switch region; other site 1009846000244 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1009846000245 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1009846000246 putative ligand binding site [chemical binding]; other site 1009846000247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846000248 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846000249 TM-ABC transporter signature motif; other site 1009846000250 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846000251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846000252 TM-ABC transporter signature motif; other site 1009846000253 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846000254 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1009846000255 putative ligand binding site [chemical binding]; other site 1009846000256 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846000257 TM-ABC transporter signature motif; other site 1009846000258 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1009846000259 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846000260 TM-ABC transporter signature motif; other site 1009846000261 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846000262 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846000263 Walker A/P-loop; other site 1009846000264 ATP binding site [chemical binding]; other site 1009846000265 Q-loop/lid; other site 1009846000266 ABC transporter signature motif; other site 1009846000267 Walker B; other site 1009846000268 D-loop; other site 1009846000269 H-loop/switch region; other site 1009846000270 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846000271 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846000272 Walker A/P-loop; other site 1009846000273 ATP binding site [chemical binding]; other site 1009846000274 Q-loop/lid; other site 1009846000275 ABC transporter signature motif; other site 1009846000276 Walker B; other site 1009846000277 D-loop; other site 1009846000278 H-loop/switch region; other site 1009846000279 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1009846000280 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1009846000281 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1009846000282 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1009846000283 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1009846000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846000285 S-adenosylmethionine binding site [chemical binding]; other site 1009846000286 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1009846000287 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846000288 P-loop; other site 1009846000289 Magnesium ion binding site [ion binding]; other site 1009846000290 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846000291 Magnesium ion binding site [ion binding]; other site 1009846000292 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1009846000293 ParB-like nuclease domain; Region: ParBc; pfam02195 1009846000294 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1009846000295 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1009846000296 transmembrane helices; other site 1009846000297 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1009846000298 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1009846000299 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1009846000300 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1009846000301 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1009846000302 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1009846000303 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1009846000304 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1009846000305 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1009846000306 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1009846000307 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1009846000308 beta subunit interaction interface [polypeptide binding]; other site 1009846000309 Walker A motif; other site 1009846000310 ATP binding site [chemical binding]; other site 1009846000311 Walker B motif; other site 1009846000312 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1009846000313 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1009846000314 core domain interface [polypeptide binding]; other site 1009846000315 delta subunit interface [polypeptide binding]; other site 1009846000316 epsilon subunit interface [polypeptide binding]; other site 1009846000317 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1009846000318 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1009846000319 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1009846000320 alpha subunit interaction interface [polypeptide binding]; other site 1009846000321 Walker A motif; other site 1009846000322 ATP binding site [chemical binding]; other site 1009846000323 Walker B motif; other site 1009846000324 inhibitor binding site; inhibition site 1009846000325 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1009846000326 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1009846000327 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1009846000328 gamma subunit interface [polypeptide binding]; other site 1009846000329 epsilon subunit interface [polypeptide binding]; other site 1009846000330 LBP interface [polypeptide binding]; other site 1009846000331 AMP-binding domain protein; Validated; Region: PRK08315 1009846000332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846000333 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1009846000334 acyl-activating enzyme (AAE) consensus motif; other site 1009846000335 putative AMP binding site [chemical binding]; other site 1009846000336 putative active site [active] 1009846000337 putative CoA binding site [chemical binding]; other site 1009846000338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846000339 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846000340 substrate binding pocket [chemical binding]; other site 1009846000341 membrane-bound complex binding site; other site 1009846000342 hinge residues; other site 1009846000343 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1009846000344 substrate binding site [chemical binding]; other site 1009846000345 active site 1009846000346 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1009846000347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846000348 ATP binding site [chemical binding]; other site 1009846000349 putative Mg++ binding site [ion binding]; other site 1009846000350 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1009846000351 nucleotide binding region [chemical binding]; other site 1009846000352 ATP-binding site [chemical binding]; other site 1009846000353 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1009846000354 Predicted transcriptional regulator [Transcription]; Region: COG3905 1009846000355 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1009846000356 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1009846000357 Glutamate binding site [chemical binding]; other site 1009846000358 NAD binding site [chemical binding]; other site 1009846000359 catalytic residues [active] 1009846000360 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846000361 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846000362 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846000363 dimerization interface [polypeptide binding]; other site 1009846000364 ligand binding site [chemical binding]; other site 1009846000365 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1009846000366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846000367 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1009846000368 acyl-activating enzyme (AAE) consensus motif; other site 1009846000369 acyl-activating enzyme (AAE) consensus motif; other site 1009846000370 putative AMP binding site [chemical binding]; other site 1009846000371 putative active site [active] 1009846000372 putative CoA binding site [chemical binding]; other site 1009846000373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846000374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846000375 active site 1009846000376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846000377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846000378 putative aminotransferase; Provisional; Region: PRK12414 1009846000379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846000380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846000381 homodimer interface [polypeptide binding]; other site 1009846000382 catalytic residue [active] 1009846000383 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1009846000384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846000385 substrate binding pocket [chemical binding]; other site 1009846000386 membrane-bound complex binding site; other site 1009846000387 hinge residues; other site 1009846000388 Predicted transcriptional regulators [Transcription]; Region: COG1695 1009846000389 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1009846000390 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1009846000391 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1009846000392 DNA binding residues [nucleotide binding] 1009846000393 dimer interface [polypeptide binding]; other site 1009846000394 putative metal binding site [ion binding]; other site 1009846000395 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1009846000396 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1009846000397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009846000398 Double zinc ribbon; Region: DZR; pfam12773 1009846000399 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846000400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846000401 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1009846000402 Conserved TM helix; Region: TM_helix; pfam05552 1009846000403 ethanolamine permease; Region: 2A0305; TIGR00908 1009846000404 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1009846000405 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1009846000406 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1009846000407 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1009846000408 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1009846000409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846000410 NAD(P) binding site [chemical binding]; other site 1009846000411 catalytic residues [active] 1009846000412 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1009846000413 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846000414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846000415 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846000416 thiamine pyrophosphate protein; Validated; Region: PRK08199 1009846000417 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846000418 PYR/PP interface [polypeptide binding]; other site 1009846000419 dimer interface [polypeptide binding]; other site 1009846000420 TPP binding site [chemical binding]; other site 1009846000421 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846000422 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1009846000423 TPP-binding site [chemical binding]; other site 1009846000424 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1009846000425 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1009846000426 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1009846000427 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1009846000428 Alginate lyase; Region: Alginate_lyase; pfam05426 1009846000429 glycine dehydrogenase; Provisional; Region: PRK05367 1009846000430 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1009846000431 tetramer interface [polypeptide binding]; other site 1009846000432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846000433 catalytic residue [active] 1009846000434 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1009846000435 tetramer interface [polypeptide binding]; other site 1009846000436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846000437 catalytic residue [active] 1009846000438 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1009846000439 lipoyl attachment site [posttranslational modification]; other site 1009846000440 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1009846000441 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1009846000442 putative oxidoreductase; Provisional; Region: PRK11579 1009846000443 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846000444 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1009846000445 Part of AAA domain; Region: AAA_19; pfam13245 1009846000446 Family description; Region: UvrD_C_2; pfam13538 1009846000447 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1009846000448 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846000449 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1009846000450 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1009846000451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846000452 binding surface 1009846000453 TPR motif; other site 1009846000454 binding surface 1009846000455 TPR motif; other site 1009846000456 Tetratricopeptide repeats; Region: TPR; smart00028 1009846000457 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846000458 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1009846000459 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1009846000460 active site 1009846000461 Flagellar protein FliT; Region: FliT; pfam05400 1009846000462 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1009846000463 flagellin; Provisional; Region: PRK12802 1009846000464 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1009846000465 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1009846000466 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1009846000467 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1009846000468 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1009846000469 putative hydrolase; Provisional; Region: PRK10976 1009846000470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846000471 active site 1009846000472 motif I; other site 1009846000473 motif II; other site 1009846000474 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1009846000475 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1009846000476 amphipathic channel; other site 1009846000477 Asn-Pro-Ala signature motifs; other site 1009846000478 H-NS histone family; Region: Histone_HNS; pfam00816 1009846000479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846000480 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1009846000481 putative ADP-binding pocket [chemical binding]; other site 1009846000482 transcriptional activator FlhD; Provisional; Region: PRK02909 1009846000483 transcriptional activator FlhC; Provisional; Region: PRK12722 1009846000484 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1009846000485 flagellar motor protein MotA; Validated; Region: PRK09110 1009846000486 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1009846000487 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1009846000488 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846000489 ligand binding site [chemical binding]; other site 1009846000490 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846000491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000492 active site 1009846000493 phosphorylation site [posttranslational modification] 1009846000494 intermolecular recognition site; other site 1009846000495 dimerization interface [polypeptide binding]; other site 1009846000496 potential frameshift: common BLAST hit: gi|170731593|ref|YP_001763540.1| CheA signal transduction histidine kinase 1009846000497 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1009846000498 putative binding surface; other site 1009846000499 active site 1009846000500 CheY binding; Region: CheY-binding; pfam09078 1009846000501 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1009846000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846000503 ATP binding site [chemical binding]; other site 1009846000504 Mg2+ binding site [ion binding]; other site 1009846000505 G-X-G motif; other site 1009846000506 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1009846000507 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1009846000508 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1009846000509 dimer interface [polypeptide binding]; other site 1009846000510 ligand binding site [chemical binding]; other site 1009846000511 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1009846000512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846000513 dimerization interface [polypeptide binding]; other site 1009846000514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846000515 dimer interface [polypeptide binding]; other site 1009846000516 putative CheW interface [polypeptide binding]; other site 1009846000517 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1009846000518 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1009846000519 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1009846000520 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 1009846000521 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1009846000522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000523 active site 1009846000524 phosphorylation site [posttranslational modification] 1009846000525 intermolecular recognition site; other site 1009846000526 dimerization interface [polypeptide binding]; other site 1009846000527 CheB methylesterase; Region: CheB_methylest; pfam01339 1009846000528 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1009846000529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000530 active site 1009846000531 phosphorylation site [posttranslational modification] 1009846000532 intermolecular recognition site; other site 1009846000533 dimerization interface [polypeptide binding]; other site 1009846000534 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1009846000535 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 1009846000536 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 1009846000537 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1009846000538 dimer interface [polypeptide binding]; other site 1009846000539 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1009846000540 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1009846000541 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1009846000542 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1009846000543 FHIPEP family; Region: FHIPEP; pfam00771 1009846000544 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 1009846000545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846000546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846000547 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1009846000548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846000549 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1009846000550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846000551 DNA binding residues [nucleotide binding] 1009846000552 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1009846000553 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1009846000554 homotetramer interface [polypeptide binding]; other site 1009846000555 ligand binding site [chemical binding]; other site 1009846000556 catalytic site [active] 1009846000557 NAD binding site [chemical binding]; other site 1009846000558 Predicted membrane protein [Function unknown]; Region: COG1950 1009846000559 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1009846000560 FAD binding site [chemical binding]; other site 1009846000561 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1009846000562 Amidase; Region: Amidase; cl11426 1009846000563 Dienelactone hydrolase family; Region: DLH; pfam01738 1009846000564 Nitronate monooxygenase; Region: NMO; pfam03060 1009846000565 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846000566 FMN binding site [chemical binding]; other site 1009846000567 substrate binding site [chemical binding]; other site 1009846000568 putative catalytic residue [active] 1009846000569 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846000570 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846000571 dimerization interface [polypeptide binding]; other site 1009846000572 ligand binding site [chemical binding]; other site 1009846000573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846000574 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1009846000575 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1009846000576 H-NS histone family; Region: Histone_HNS; pfam00816 1009846000577 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1009846000578 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1009846000579 Cation efflux family; Region: Cation_efflux; pfam01545 1009846000580 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846000581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846000582 putative DNA binding site [nucleotide binding]; other site 1009846000583 putative Zn2+ binding site [ion binding]; other site 1009846000584 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846000585 active site 1009846000586 catalytic site [active] 1009846000587 substrate binding site [chemical binding]; other site 1009846000588 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1009846000589 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1009846000590 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1009846000591 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1009846000592 Predicted methyltransferases [General function prediction only]; Region: COG0313 1009846000593 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1009846000594 putative SAM binding site [chemical binding]; other site 1009846000595 putative homodimer interface [polypeptide binding]; other site 1009846000596 hypothetical protein; Provisional; Region: PRK14673 1009846000597 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1009846000598 active site 1009846000599 dimer interface [polypeptide binding]; other site 1009846000600 BON domain; Region: BON; pfam04972 1009846000601 BON domain; Region: BON; cl02771 1009846000602 Cytochrome c; Region: Cytochrom_C; cl11414 1009846000603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846000604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1009846000605 Predicted membrane protein [Function unknown]; Region: COG2246 1009846000606 GtrA-like protein; Region: GtrA; pfam04138 1009846000607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1009846000608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846000609 S-adenosylmethionine binding site [chemical binding]; other site 1009846000610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846000611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846000612 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1009846000613 Ligand binding site; other site 1009846000614 Putative Catalytic site; other site 1009846000615 DXD motif; other site 1009846000616 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1009846000617 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1009846000618 active site 1009846000619 tetramer interface [polypeptide binding]; other site 1009846000620 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846000621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846000622 putative substrate translocation pore; other site 1009846000623 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1009846000624 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1009846000625 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1009846000626 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1009846000627 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009846000628 FtsX-like permease family; Region: FtsX; pfam02687 1009846000629 FtsX-like permease family; Region: FtsX; pfam02687 1009846000630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1009846000631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009846000632 Walker A/P-loop; other site 1009846000633 ATP binding site [chemical binding]; other site 1009846000634 Q-loop/lid; other site 1009846000635 ABC transporter signature motif; other site 1009846000636 Walker B; other site 1009846000637 D-loop; other site 1009846000638 H-loop/switch region; other site 1009846000639 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846000640 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846000641 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1009846000642 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1009846000643 Protein of unknown function DUF82; Region: DUF82; pfam01927 1009846000644 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1009846000645 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846000646 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846000647 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1009846000648 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 1009846000649 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 1009846000650 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1009846000651 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009846000652 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1009846000653 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846000654 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1009846000655 substrate binding site [chemical binding]; other site 1009846000656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846000657 active site 1009846000658 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1009846000659 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1009846000660 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1009846000661 putative NAD(P) binding site [chemical binding]; other site 1009846000662 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1009846000663 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1009846000664 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1009846000665 dimer interface [polypeptide binding]; other site 1009846000666 PYR/PP interface [polypeptide binding]; other site 1009846000667 TPP binding site [chemical binding]; other site 1009846000668 substrate binding site [chemical binding]; other site 1009846000669 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1009846000670 TPP-binding site; other site 1009846000671 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1009846000672 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1009846000673 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1009846000674 dimer interface [polypeptide binding]; other site 1009846000675 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1009846000676 active site 1009846000677 Fe binding site [ion binding]; other site 1009846000678 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846000679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846000680 putative DNA binding site [nucleotide binding]; other site 1009846000681 putative Zn2+ binding site [ion binding]; other site 1009846000682 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846000683 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009846000684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846000685 Coenzyme A binding pocket [chemical binding]; other site 1009846000686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846000687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846000688 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1009846000689 Protein of unknown function; Region: DUF3658; pfam12395 1009846000690 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1009846000691 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1009846000692 FAD binding pocket [chemical binding]; other site 1009846000693 FAD binding motif [chemical binding]; other site 1009846000694 phosphate binding motif [ion binding]; other site 1009846000695 beta-alpha-beta structure motif; other site 1009846000696 NAD(p) ribose binding residues [chemical binding]; other site 1009846000697 NAD binding pocket [chemical binding]; other site 1009846000698 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1009846000699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846000700 catalytic loop [active] 1009846000701 iron binding site [ion binding]; other site 1009846000702 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1009846000703 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1009846000704 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1009846000705 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1009846000706 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1009846000707 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1009846000708 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1009846000709 active site 1009846000710 catalytic triad [active] 1009846000711 oxyanion hole [active] 1009846000712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1009846000713 HTH-like domain; Region: HTH_21; pfam13276 1009846000714 Integrase core domain; Region: rve; pfam00665 1009846000715 Integrase core domain; Region: rve_3; pfam13683 1009846000716 Transposase; Region: HTH_Tnp_1; pfam01527 1009846000717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1009846000718 Integrase core domain; Region: rve; pfam00665 1009846000719 Integrase core domain; Region: rve_3; pfam13683 1009846000720 Integrase core domain; Region: rve; pfam00665 1009846000721 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1009846000722 Peptidase M15; Region: Peptidase_M15_3; cl01194 1009846000723 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1009846000724 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1009846000725 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1009846000726 Active Sites [active] 1009846000727 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1009846000728 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1009846000729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846000730 ATP binding site [chemical binding]; other site 1009846000731 Mg2+ binding site [ion binding]; other site 1009846000732 G-X-G motif; other site 1009846000733 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1009846000734 anchoring element; other site 1009846000735 dimer interface [polypeptide binding]; other site 1009846000736 ATP binding site [chemical binding]; other site 1009846000737 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1009846000738 active site 1009846000739 putative metal-binding site [ion binding]; other site 1009846000740 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1009846000741 DNA polymerase III subunit beta; Validated; Region: PRK05643 1009846000742 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1009846000743 putative DNA binding surface [nucleotide binding]; other site 1009846000744 dimer interface [polypeptide binding]; other site 1009846000745 beta-clamp/clamp loader binding surface; other site 1009846000746 beta-clamp/translesion DNA polymerase binding surface; other site 1009846000747 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1009846000748 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1009846000749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846000750 Walker A motif; other site 1009846000751 ATP binding site [chemical binding]; other site 1009846000752 Walker B motif; other site 1009846000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1009846000754 arginine finger; other site 1009846000755 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1009846000756 DnaA box-binding interface [nucleotide binding]; other site 1009846000757 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1009846000758 membrane protein insertase; Provisional; Region: PRK01318 1009846000759 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1009846000760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846000761 non-specific DNA binding site [nucleotide binding]; other site 1009846000762 salt bridge; other site 1009846000763 sequence-specific DNA binding site [nucleotide binding]; other site 1009846000764 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1009846000765 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1009846000766 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1009846000767 G1 box; other site 1009846000768 GTP/Mg2+ binding site [chemical binding]; other site 1009846000769 Switch I region; other site 1009846000770 G2 box; other site 1009846000771 Switch II region; other site 1009846000772 G3 box; other site 1009846000773 G4 box; other site 1009846000774 G5 box; other site 1009846000775 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1009846000776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846000777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846000778 metal binding site [ion binding]; metal-binding site 1009846000779 active site 1009846000780 I-site; other site 1009846000781 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1009846000782 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1009846000783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846000784 Coenzyme A binding pocket [chemical binding]; other site 1009846000785 YaeQ protein; Region: YaeQ; pfam07152 1009846000786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1009846000787 dimer interface [polypeptide binding]; other site 1009846000788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846000789 metal binding site [ion binding]; metal-binding site 1009846000790 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1009846000791 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1009846000792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846000793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846000794 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1009846000795 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1009846000796 DNA binding site [nucleotide binding] 1009846000797 active site 1009846000798 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1009846000799 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1009846000800 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1009846000801 minor groove reading motif; other site 1009846000802 helix-hairpin-helix signature motif; other site 1009846000803 substrate binding pocket [chemical binding]; other site 1009846000804 active site 1009846000805 glutamate--cysteine ligase; Provisional; Region: PRK02107 1009846000806 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846000807 L-lactate permease; Region: Lactate_perm; cl00701 1009846000808 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1009846000809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846000810 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1009846000811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846000812 dimerization interface [polypeptide binding]; other site 1009846000813 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1009846000814 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1009846000815 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846000816 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846000817 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1009846000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846000819 DNA-binding site [nucleotide binding]; DNA binding site 1009846000820 FCD domain; Region: FCD; pfam07729 1009846000821 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846000822 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846000823 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1009846000824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846000825 catalytic residue [active] 1009846000826 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1009846000827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846000828 dimer interface [polypeptide binding]; other site 1009846000829 conserved gate region; other site 1009846000830 putative PBP binding loops; other site 1009846000831 ABC-ATPase subunit interface; other site 1009846000832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846000833 dimer interface [polypeptide binding]; other site 1009846000834 conserved gate region; other site 1009846000835 putative PBP binding loops; other site 1009846000836 ABC-ATPase subunit interface; other site 1009846000837 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1009846000838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846000839 Walker A/P-loop; other site 1009846000840 ATP binding site [chemical binding]; other site 1009846000841 Q-loop/lid; other site 1009846000842 ABC transporter signature motif; other site 1009846000843 Walker B; other site 1009846000844 D-loop; other site 1009846000845 H-loop/switch region; other site 1009846000846 TOBE domain; Region: TOBE_2; pfam08402 1009846000847 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1009846000848 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 1009846000849 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1009846000850 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1009846000851 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 1009846000852 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 1009846000853 NAD(P) binding site [chemical binding]; other site 1009846000854 catalytic residues [active] 1009846000855 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846000856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846000857 substrate binding pocket [chemical binding]; other site 1009846000858 membrane-bound complex binding site; other site 1009846000859 hinge residues; other site 1009846000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846000861 dimer interface [polypeptide binding]; other site 1009846000862 conserved gate region; other site 1009846000863 putative PBP binding loops; other site 1009846000864 ABC-ATPase subunit interface; other site 1009846000865 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846000866 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846000867 Walker A/P-loop; other site 1009846000868 ATP binding site [chemical binding]; other site 1009846000869 Q-loop/lid; other site 1009846000870 ABC transporter signature motif; other site 1009846000871 Walker B; other site 1009846000872 D-loop; other site 1009846000873 H-loop/switch region; other site 1009846000874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846000875 CGNR zinc finger; Region: zf-CGNR; pfam11706 1009846000876 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1009846000877 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1009846000878 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1009846000879 CoenzymeA binding site [chemical binding]; other site 1009846000880 subunit interaction site [polypeptide binding]; other site 1009846000881 PHB binding site; other site 1009846000882 Patatin-like phospholipase; Region: Patatin; pfam01734 1009846000883 active site 1009846000884 nucleophile elbow; other site 1009846000885 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1009846000886 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1009846000887 dimerization interface [polypeptide binding]; other site 1009846000888 NAD binding site [chemical binding]; other site 1009846000889 ligand binding site [chemical binding]; other site 1009846000890 catalytic site [active] 1009846000891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846000892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846000893 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846000894 putative effector binding pocket; other site 1009846000895 dimerization interface [polypeptide binding]; other site 1009846000896 DNA topoisomerase III; Validated; Region: PRK08173 1009846000897 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1009846000898 active site 1009846000899 putative interdomain interaction site [polypeptide binding]; other site 1009846000900 putative metal-binding site [ion binding]; other site 1009846000901 putative nucleotide binding site [chemical binding]; other site 1009846000902 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1009846000903 domain I; other site 1009846000904 DNA binding groove [nucleotide binding] 1009846000905 phosphate binding site [ion binding]; other site 1009846000906 domain II; other site 1009846000907 domain III; other site 1009846000908 nucleotide binding site [chemical binding]; other site 1009846000909 catalytic site [active] 1009846000910 domain IV; other site 1009846000911 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1009846000912 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1009846000913 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009846000914 catalytic residues [active] 1009846000915 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1009846000916 DNA protecting protein DprA; Region: dprA; TIGR00732 1009846000917 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1009846000918 active site 1009846000919 catalytic residues [active] 1009846000920 metal binding site [ion binding]; metal-binding site 1009846000921 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1009846000922 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1009846000923 putative active site [active] 1009846000924 substrate binding site [chemical binding]; other site 1009846000925 putative cosubstrate binding site; other site 1009846000926 catalytic site [active] 1009846000927 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1009846000928 substrate binding site [chemical binding]; other site 1009846000929 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846000930 M48 family peptidase; Provisional; Region: PRK03001 1009846000931 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1009846000932 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1009846000933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846000934 S-adenosylmethionine binding site [chemical binding]; other site 1009846000935 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1009846000936 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1009846000937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846000938 dimerization interface [polypeptide binding]; other site 1009846000939 PAS domain; Region: PAS; smart00091 1009846000940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846000941 dimer interface [polypeptide binding]; other site 1009846000942 phosphorylation site [posttranslational modification] 1009846000943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846000944 ATP binding site [chemical binding]; other site 1009846000945 Mg2+ binding site [ion binding]; other site 1009846000946 G-X-G motif; other site 1009846000947 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846000948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846000949 active site 1009846000950 phosphorylation site [posttranslational modification] 1009846000951 intermolecular recognition site; other site 1009846000952 dimerization interface [polypeptide binding]; other site 1009846000953 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1009846000954 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1009846000955 Ligand Binding Site [chemical binding]; other site 1009846000956 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1009846000957 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1009846000958 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1009846000959 active site 1009846000960 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1009846000961 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1009846000962 Sel1-like repeats; Region: SEL1; smart00671 1009846000963 Sel1-like repeats; Region: SEL1; smart00671 1009846000964 Sel1-like repeats; Region: SEL1; smart00671 1009846000965 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1009846000966 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1009846000967 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1009846000968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009846000969 rod shape-determining protein MreC; Provisional; Region: PRK13922 1009846000970 rod shape-determining protein MreC; Region: MreC; pfam04085 1009846000971 rod shape-determining protein MreB; Provisional; Region: PRK13927 1009846000972 MreB and similar proteins; Region: MreB_like; cd10225 1009846000973 nucleotide binding site [chemical binding]; other site 1009846000974 Mg binding site [ion binding]; other site 1009846000975 putative protofilament interaction site [polypeptide binding]; other site 1009846000976 RodZ interaction site [polypeptide binding]; other site 1009846000977 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1009846000978 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1009846000979 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1009846000980 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1009846000981 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1009846000982 GatB domain; Region: GatB_Yqey; smart00845 1009846000983 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1009846000984 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1009846000985 putative active site [active] 1009846000986 putative catalytic site [active] 1009846000987 putative DNA binding site [nucleotide binding]; other site 1009846000988 putative phosphate binding site [ion binding]; other site 1009846000989 metal binding site A [ion binding]; metal-binding site 1009846000990 putative AP binding site [nucleotide binding]; other site 1009846000991 putative metal binding site B [ion binding]; other site 1009846000992 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1009846000993 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1009846000994 putative NAD(P) binding site [chemical binding]; other site 1009846000995 putative substrate binding site [chemical binding]; other site 1009846000996 catalytic Zn binding site [ion binding]; other site 1009846000997 structural Zn binding site [ion binding]; other site 1009846000998 dimer interface [polypeptide binding]; other site 1009846000999 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1009846001000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846001001 Peptidase family M48; Region: Peptidase_M48; cl12018 1009846001002 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1009846001003 AmpG-like permease; Region: 2A0125; TIGR00901 1009846001004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846001005 S-adenosylmethionine binding site [chemical binding]; other site 1009846001006 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1009846001007 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1009846001008 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846001009 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846001010 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1009846001011 PapC N-terminal domain; Region: PapC_N; pfam13954 1009846001012 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846001013 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846001014 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846001015 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1009846001016 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846001017 division inhibitor protein; Provisional; Region: slmA; PRK09480 1009846001018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846001019 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1009846001020 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1009846001021 homohexameric interface [polypeptide binding]; other site 1009846001022 N-acetyl-L-glutamate binding site [chemical binding]; other site 1009846001023 nucleotide binding site [chemical binding]; other site 1009846001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846001025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1009846001026 dimer interface [polypeptide binding]; other site 1009846001027 phosphorylation site [posttranslational modification] 1009846001028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846001029 ATP binding site [chemical binding]; other site 1009846001030 Mg2+ binding site [ion binding]; other site 1009846001031 G-X-G motif; other site 1009846001032 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1009846001033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846001034 active site 1009846001035 phosphorylation site [posttranslational modification] 1009846001036 intermolecular recognition site; other site 1009846001037 dimerization interface [polypeptide binding]; other site 1009846001038 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846001039 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1009846001040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846001041 Walker A motif; other site 1009846001042 ATP binding site [chemical binding]; other site 1009846001043 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1009846001044 Walker B motif; other site 1009846001045 arginine finger; other site 1009846001046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1009846001047 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1009846001048 active site 1009846001049 HslU subunit interaction site [polypeptide binding]; other site 1009846001050 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1009846001051 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1009846001052 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1009846001053 P-loop, Walker A motif; other site 1009846001054 Base recognition motif; other site 1009846001055 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1009846001056 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1009846001057 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1009846001058 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1009846001059 putative RNA binding site [nucleotide binding]; other site 1009846001060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846001061 S-adenosylmethionine binding site [chemical binding]; other site 1009846001062 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1009846001063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009846001064 active site 1009846001065 DNA binding site [nucleotide binding] 1009846001066 Int/Topo IB signature motif; other site 1009846001067 Protein of unknown function, DUF484; Region: DUF484; cl17449 1009846001068 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1009846001069 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1009846001070 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1009846001071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009846001072 sequence-specific DNA binding site [nucleotide binding]; other site 1009846001073 salt bridge; other site 1009846001074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1009846001075 putative acyl-acceptor binding pocket; other site 1009846001076 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1009846001077 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1009846001078 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1009846001079 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1009846001080 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1009846001081 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 1009846001082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846001083 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846001084 active site 1009846001085 catalytic tetrad [active] 1009846001086 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846001087 EamA-like transporter family; Region: EamA; pfam00892 1009846001088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846001089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846001090 putative substrate translocation pore; other site 1009846001091 serine/threonine protein kinase; Provisional; Region: PRK11768 1009846001092 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1009846001093 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846001094 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1009846001095 NAD(P) binding site [chemical binding]; other site 1009846001096 catalytic residues [active] 1009846001097 choline dehydrogenase; Validated; Region: PRK02106 1009846001098 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846001099 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1009846001100 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1009846001101 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1009846001102 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1009846001103 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1009846001104 Walker A motif/ATP binding site; other site 1009846001105 Walker B motif; other site 1009846001106 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1009846001107 Flagellar assembly protein FliH; Region: FliH; pfam02108 1009846001108 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1009846001109 FliG C-terminal domain; Region: FliG_C; pfam01706 1009846001110 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1009846001111 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1009846001112 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1009846001113 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1009846001114 Flagellar protein FliS; Region: FliS; cl00654 1009846001115 Flagellar protein FliT; Region: FliT; cl05125 1009846001116 Flagellar protein FliT; Region: FliT; cl05125 1009846001117 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1009846001118 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1009846001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1009846001120 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1009846001121 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1009846001122 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1009846001123 amino acid transporter; Region: 2A0306; TIGR00909 1009846001124 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1009846001125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846001127 active site 1009846001128 phosphorylation site [posttranslational modification] 1009846001129 intermolecular recognition site; other site 1009846001130 dimerization interface [polypeptide binding]; other site 1009846001131 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846001132 DNA binding residues [nucleotide binding] 1009846001133 dimerization interface [polypeptide binding]; other site 1009846001134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009846001135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846001136 ATP binding site [chemical binding]; other site 1009846001137 Mg2+ binding site [ion binding]; other site 1009846001138 G-X-G motif; other site 1009846001139 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1009846001140 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1009846001141 FAD binding pocket [chemical binding]; other site 1009846001142 FAD binding motif [chemical binding]; other site 1009846001143 phosphate binding motif [ion binding]; other site 1009846001144 beta-alpha-beta structure motif; other site 1009846001145 NAD binding pocket [chemical binding]; other site 1009846001146 LysE type translocator; Region: LysE; cl00565 1009846001147 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1009846001148 putative catalytic site [active] 1009846001149 putative phosphate binding site [ion binding]; other site 1009846001150 putative metal binding site [ion binding]; other site 1009846001151 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1009846001152 putative FMN binding site [chemical binding]; other site 1009846001153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846001154 ATP binding site [chemical binding]; other site 1009846001155 Walker B motif; other site 1009846001156 arginine finger; other site 1009846001157 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1009846001158 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846001159 High potential iron-sulfur protein; Region: HIPIP; pfam01355 1009846001160 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846001161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846001162 putative substrate translocation pore; other site 1009846001163 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1009846001164 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1009846001165 peptide binding site [polypeptide binding]; other site 1009846001166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009846001167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846001168 dimer interface [polypeptide binding]; other site 1009846001169 conserved gate region; other site 1009846001170 putative PBP binding loops; other site 1009846001171 ABC-ATPase subunit interface; other site 1009846001172 dipeptide transporter; Provisional; Region: PRK10913 1009846001173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846001174 dimer interface [polypeptide binding]; other site 1009846001175 conserved gate region; other site 1009846001176 putative PBP binding loops; other site 1009846001177 ABC-ATPase subunit interface; other site 1009846001178 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1009846001179 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846001180 Walker A/P-loop; other site 1009846001181 ATP binding site [chemical binding]; other site 1009846001182 Q-loop/lid; other site 1009846001183 ABC transporter signature motif; other site 1009846001184 Walker B; other site 1009846001185 D-loop; other site 1009846001186 H-loop/switch region; other site 1009846001187 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846001188 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1009846001189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846001190 Walker A/P-loop; other site 1009846001191 ATP binding site [chemical binding]; other site 1009846001192 Q-loop/lid; other site 1009846001193 ABC transporter signature motif; other site 1009846001194 Walker B; other site 1009846001195 D-loop; other site 1009846001196 H-loop/switch region; other site 1009846001197 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1009846001198 TraB family; Region: TraB; pfam01963 1009846001199 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1009846001200 putative active site [active] 1009846001201 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1009846001202 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1009846001203 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1009846001204 MarR family; Region: MarR_2; cl17246 1009846001205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846001206 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1009846001207 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1009846001208 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846001209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846001210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846001211 catalytic residue [active] 1009846001212 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1009846001213 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1009846001214 putative NAD(P) binding site [chemical binding]; other site 1009846001215 active site 1009846001216 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846001217 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1009846001218 putative C-terminal domain interface [polypeptide binding]; other site 1009846001219 putative GSH binding site (G-site) [chemical binding]; other site 1009846001220 putative dimer interface [polypeptide binding]; other site 1009846001221 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1009846001222 putative N-terminal domain interface [polypeptide binding]; other site 1009846001223 putative dimer interface [polypeptide binding]; other site 1009846001224 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846001225 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1009846001226 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1009846001227 active site 1009846001228 NTP binding site [chemical binding]; other site 1009846001229 metal binding triad [ion binding]; metal-binding site 1009846001230 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1009846001231 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 1009846001232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846001233 sequence-specific DNA binding site [nucleotide binding]; other site 1009846001234 salt bridge; other site 1009846001235 Cupin domain; Region: Cupin_2; pfam07883 1009846001236 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1009846001237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1009846001238 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1009846001239 active site 1009846001240 FlgN protein; Region: FlgN; pfam05130 1009846001241 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1009846001242 SAF-like; Region: SAF_2; pfam13144 1009846001243 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1009846001244 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 1009846001245 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1009846001246 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1009846001247 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1009846001248 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1009846001249 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1009846001250 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1009846001251 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1009846001252 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1009846001253 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1009846001254 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1009846001255 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1009846001256 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1009846001257 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1009846001258 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 1009846001259 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1009846001260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1009846001261 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 1009846001262 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1009846001263 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1009846001264 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1009846001265 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 1009846001266 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1009846001267 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1009846001268 Flagellar regulator YcgR; Region: YcgR; pfam07317 1009846001269 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1009846001270 PilZ domain; Region: PilZ; pfam07238 1009846001271 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 1009846001272 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1009846001273 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1009846001274 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1009846001275 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1009846001276 Spore Coat Protein U domain; Region: SCPU; pfam05229 1009846001277 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1009846001278 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846001279 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846001280 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1009846001281 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846001282 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1009846001283 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846001284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846001285 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846001286 dimerization interface [polypeptide binding]; other site 1009846001287 substrate binding pocket [chemical binding]; other site 1009846001288 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1009846001289 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846001290 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846001291 trimer interface [polypeptide binding]; other site 1009846001292 eyelet of channel; other site 1009846001293 glutathione reductase; Validated; Region: PRK06116 1009846001294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846001295 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009846001296 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846001297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846001298 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846001299 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1009846001300 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 1009846001301 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1009846001302 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846001303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846001304 dimer interface [polypeptide binding]; other site 1009846001305 conserved gate region; other site 1009846001306 putative PBP binding loops; other site 1009846001307 ABC-ATPase subunit interface; other site 1009846001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846001309 dimer interface [polypeptide binding]; other site 1009846001310 conserved gate region; other site 1009846001311 putative PBP binding loops; other site 1009846001312 ABC-ATPase subunit interface; other site 1009846001313 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1009846001314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846001315 Walker A/P-loop; other site 1009846001316 ATP binding site [chemical binding]; other site 1009846001317 Q-loop/lid; other site 1009846001318 ABC transporter signature motif; other site 1009846001319 Walker B; other site 1009846001320 D-loop; other site 1009846001321 H-loop/switch region; other site 1009846001322 TOBE domain; Region: TOBE_2; pfam08402 1009846001323 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1009846001324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846001325 putative aminotransferase; Validated; Region: PRK07480 1009846001326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846001327 inhibitor-cofactor binding pocket; inhibition site 1009846001328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846001329 catalytic residue [active] 1009846001330 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1009846001331 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009846001332 Peptidase C26; Region: Peptidase_C26; pfam07722 1009846001333 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1009846001334 catalytic triad [active] 1009846001335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846001336 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1009846001337 non-specific DNA binding site [nucleotide binding]; other site 1009846001338 salt bridge; other site 1009846001339 sequence-specific DNA binding site [nucleotide binding]; other site 1009846001340 Cupin domain; Region: Cupin_2; pfam07883 1009846001341 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1009846001342 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1009846001343 NAD(P) binding site [chemical binding]; other site 1009846001344 catalytic residues [active] 1009846001345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1009846001346 metal-binding site [ion binding] 1009846001347 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1009846001348 Iron permease FTR1 family; Region: FTR1; cl00475 1009846001349 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1009846001350 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1009846001351 glutaminase active site [active] 1009846001352 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009846001353 dimer interface [polypeptide binding]; other site 1009846001354 active site 1009846001355 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009846001356 dimer interface [polypeptide binding]; other site 1009846001357 active site 1009846001358 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1009846001359 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1009846001360 Substrate binding site; other site 1009846001361 Mg++ binding site; other site 1009846001362 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1009846001363 active site 1009846001364 substrate binding site [chemical binding]; other site 1009846001365 CoA binding site [chemical binding]; other site 1009846001366 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1009846001367 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1009846001368 Ligand Binding Site [chemical binding]; other site 1009846001369 Dihydroneopterin aldolase; Region: FolB; smart00905 1009846001370 active site 1009846001371 short chain dehydrogenase; Provisional; Region: PRK09134 1009846001372 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1009846001373 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1009846001374 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1009846001375 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846001376 putative substrate binding site [chemical binding]; other site 1009846001377 putative ATP binding site [chemical binding]; other site 1009846001378 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1009846001379 dimerization interface [polypeptide binding]; other site 1009846001380 putative active cleft [active] 1009846001381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846001382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846001383 DNA binding site [nucleotide binding] 1009846001384 domain linker motif; other site 1009846001385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009846001386 ligand binding site [chemical binding]; other site 1009846001387 dimerization interface [polypeptide binding]; other site 1009846001388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846001389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1009846001390 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846001391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846001392 metal binding site [ion binding]; metal-binding site 1009846001393 active site 1009846001394 I-site; other site 1009846001395 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1009846001396 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1009846001397 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846001398 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846001399 trimer interface [polypeptide binding]; other site 1009846001400 eyelet of channel; other site 1009846001401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846001402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846001403 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846001404 putative effector binding pocket; other site 1009846001405 dimerization interface [polypeptide binding]; other site 1009846001406 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1009846001407 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846001408 FMN binding site [chemical binding]; other site 1009846001409 substrate binding site [chemical binding]; other site 1009846001410 putative catalytic residue [active] 1009846001411 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846001412 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846001413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846001414 dimerization interface [polypeptide binding]; other site 1009846001415 putative DNA binding site [nucleotide binding]; other site 1009846001416 putative Zn2+ binding site [ion binding]; other site 1009846001417 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846001418 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846001419 EamA-like transporter family; Region: EamA; pfam00892 1009846001420 EamA-like transporter family; Region: EamA; pfam00892 1009846001421 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1009846001422 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1009846001423 putative deacylase active site [active] 1009846001424 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1009846001425 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1009846001426 active site 1009846001427 catalytic residues [active] 1009846001428 metal binding site [ion binding]; metal-binding site 1009846001429 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1009846001430 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1009846001431 putative ligand binding site [chemical binding]; other site 1009846001432 NAD binding site [chemical binding]; other site 1009846001433 dimerization interface [polypeptide binding]; other site 1009846001434 catalytic site [active] 1009846001435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1009846001436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846001437 putative metal binding site [ion binding]; other site 1009846001438 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1009846001439 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846001440 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1009846001441 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1009846001442 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846001443 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846001444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846001445 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1009846001446 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846001447 N-terminal plug; other site 1009846001448 ligand-binding site [chemical binding]; other site 1009846001449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846001450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846001451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846001452 dimerization interface [polypeptide binding]; other site 1009846001453 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1009846001454 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1009846001455 putative active site [active] 1009846001456 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846001457 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1009846001458 dimer interface [polypeptide binding]; other site 1009846001459 active site 1009846001460 catalytic residue [active] 1009846001461 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1009846001462 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846001463 Inward rectifier potassium channel; Region: IRK; pfam01007 1009846001464 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846001465 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1009846001466 putative C-terminal domain interface [polypeptide binding]; other site 1009846001467 putative GSH binding site (G-site) [chemical binding]; other site 1009846001468 putative dimer interface [polypeptide binding]; other site 1009846001469 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1009846001470 dimer interface [polypeptide binding]; other site 1009846001471 N-terminal domain interface [polypeptide binding]; other site 1009846001472 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846001473 maltose O-acetyltransferase; Provisional; Region: PRK10092 1009846001474 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1009846001475 active site 1009846001476 substrate binding site [chemical binding]; other site 1009846001477 trimer interface [polypeptide binding]; other site 1009846001478 CoA binding site [chemical binding]; other site 1009846001479 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 1009846001480 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1009846001481 dimer interface [polypeptide binding]; other site 1009846001482 PYR/PP interface [polypeptide binding]; other site 1009846001483 TPP binding site [chemical binding]; other site 1009846001484 substrate binding site [chemical binding]; other site 1009846001485 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1009846001486 TPP-binding site; other site 1009846001487 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1009846001488 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1009846001489 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846001490 CutC family; Region: CutC; cl01218 1009846001491 biotin synthase; Region: bioB; TIGR00433 1009846001492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846001493 FeS/SAM binding site; other site 1009846001494 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1009846001495 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1009846001496 AAA domain; Region: AAA_26; pfam13500 1009846001497 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1009846001498 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1009846001499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846001500 catalytic residue [active] 1009846001501 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 1009846001502 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846001503 inhibitor-cofactor binding pocket; inhibition site 1009846001504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846001505 catalytic residue [active] 1009846001506 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1009846001507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009846001508 hypothetical protein; Provisional; Region: PRK01842 1009846001509 short chain dehydrogenase; Provisional; Region: PRK08219 1009846001510 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1009846001511 NADP binding site [chemical binding]; other site 1009846001512 homodimer interface [polypeptide binding]; other site 1009846001513 active site 1009846001514 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1009846001515 active site clefts [active] 1009846001516 zinc binding site [ion binding]; other site 1009846001517 dimer interface [polypeptide binding]; other site 1009846001518 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1009846001519 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1009846001520 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1009846001521 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1009846001522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846001523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846001524 Walker A/P-loop; other site 1009846001525 Walker A/P-loop; other site 1009846001526 ATP binding site [chemical binding]; other site 1009846001527 ATP binding site [chemical binding]; other site 1009846001528 Q-loop/lid; other site 1009846001529 Q-loop/lid; other site 1009846001530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846001531 ABC transporter signature motif; other site 1009846001532 Walker B; other site 1009846001533 D-loop; other site 1009846001534 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846001535 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1009846001536 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1009846001537 peptide binding site [polypeptide binding]; other site 1009846001538 short chain dehydrogenase; Provisional; Region: PRK07024 1009846001539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846001540 NAD(P) binding site [chemical binding]; other site 1009846001541 active site 1009846001542 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1009846001543 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1009846001544 catalytic residues [active] 1009846001545 hinge region; other site 1009846001546 alpha helical domain; other site 1009846001547 Sporulation related domain; Region: SPOR; pfam05036 1009846001548 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1009846001549 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1009846001550 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1009846001551 active site 1009846001552 HIGH motif; other site 1009846001553 KMSK motif region; other site 1009846001554 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1009846001555 tRNA binding surface [nucleotide binding]; other site 1009846001556 anticodon binding site; other site 1009846001557 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1009846001558 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1009846001559 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1009846001560 substrate binding pocket [chemical binding]; other site 1009846001561 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1009846001562 B12 binding site [chemical binding]; other site 1009846001563 cobalt ligand [ion binding]; other site 1009846001564 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1009846001565 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1009846001566 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1009846001567 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 1009846001568 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1009846001569 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846001570 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846001571 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846001572 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846001573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846001574 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1009846001575 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846001576 substrate binding site [chemical binding]; other site 1009846001577 oxyanion hole (OAH) forming residues; other site 1009846001578 trimer interface [polypeptide binding]; other site 1009846001579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1009846001580 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1009846001581 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1009846001582 active site 1009846001583 nucleophile elbow; other site 1009846001584 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1009846001585 dinuclear metal binding motif [ion binding]; other site 1009846001586 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1009846001587 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1009846001588 active site 1009846001589 HIGH motif; other site 1009846001590 nucleotide binding site [chemical binding]; other site 1009846001591 pantothenate kinase; Reviewed; Region: PRK13328 1009846001592 biotin--protein ligase; Provisional; Region: PRK06955 1009846001593 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1009846001594 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1009846001595 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1009846001596 Sel1-like repeats; Region: SEL1; smart00671 1009846001597 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1009846001598 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1009846001599 active site 1009846001600 metal binding site [ion binding]; metal-binding site 1009846001601 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1009846001602 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1009846001603 Permease; Region: Permease; pfam02405 1009846001604 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1009846001605 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1009846001606 Walker A/P-loop; other site 1009846001607 ATP binding site [chemical binding]; other site 1009846001608 Q-loop/lid; other site 1009846001609 ABC transporter signature motif; other site 1009846001610 Walker B; other site 1009846001611 D-loop; other site 1009846001612 H-loop/switch region; other site 1009846001613 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1009846001614 mce related protein; Region: MCE; pfam02470 1009846001615 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1009846001616 Predicted integral membrane protein [Function unknown]; Region: COG5652 1009846001617 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1009846001618 dimer interface [polypeptide binding]; other site 1009846001619 [2Fe-2S] cluster binding site [ion binding]; other site 1009846001620 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1009846001621 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1009846001622 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1009846001623 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1009846001624 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1009846001625 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1009846001626 homodimer interface [polypeptide binding]; other site 1009846001627 substrate-cofactor binding pocket; other site 1009846001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846001629 catalytic residue [active] 1009846001630 hypothetical protein; Provisional; Region: PRK02047 1009846001631 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846001632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846001633 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846001634 dimerization interface [polypeptide binding]; other site 1009846001635 substrate binding pocket [chemical binding]; other site 1009846001636 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1009846001637 lipoate-protein ligase B; Provisional; Region: PRK14343 1009846001638 lipoyl synthase; Provisional; Region: PRK05481 1009846001639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846001640 FeS/SAM binding site; other site 1009846001641 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1009846001642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846001643 substrate binding pocket [chemical binding]; other site 1009846001644 membrane-bound complex binding site; other site 1009846001645 hinge residues; other site 1009846001646 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 1009846001647 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846001648 Walker A/P-loop; other site 1009846001649 ATP binding site [chemical binding]; other site 1009846001650 Q-loop/lid; other site 1009846001651 ABC transporter signature motif; other site 1009846001652 Walker B; other site 1009846001653 D-loop; other site 1009846001654 H-loop/switch region; other site 1009846001655 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846001656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846001657 dimer interface [polypeptide binding]; other site 1009846001658 conserved gate region; other site 1009846001659 putative PBP binding loops; other site 1009846001660 ABC-ATPase subunit interface; other site 1009846001661 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1009846001662 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1009846001663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846001664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846001665 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846001666 putative effector binding pocket; other site 1009846001667 dimerization interface [polypeptide binding]; other site 1009846001668 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1009846001669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846001670 substrate binding site [chemical binding]; other site 1009846001671 oxyanion hole (OAH) forming residues; other site 1009846001672 trimer interface [polypeptide binding]; other site 1009846001673 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846001674 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846001675 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1009846001676 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846001677 active site 1009846001678 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1009846001679 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1009846001680 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1009846001681 active site 1009846001682 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846001683 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846001684 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1009846001685 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1009846001686 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1009846001687 Na binding site [ion binding]; other site 1009846001688 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1009846001689 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846001690 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1009846001691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846001692 dimer interface [polypeptide binding]; other site 1009846001693 phosphorylation site [posttranslational modification] 1009846001694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846001695 ATP binding site [chemical binding]; other site 1009846001696 G-X-G motif; other site 1009846001697 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846001698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846001699 active site 1009846001700 phosphorylation site [posttranslational modification] 1009846001701 intermolecular recognition site; other site 1009846001702 dimerization interface [polypeptide binding]; other site 1009846001703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846001704 Walker A motif; other site 1009846001705 ATP binding site [chemical binding]; other site 1009846001706 Walker B motif; other site 1009846001707 arginine finger; other site 1009846001708 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846001709 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1009846001710 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846001711 catalytic residues [active] 1009846001712 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1009846001713 AAA domain; Region: AAA_31; pfam13614 1009846001714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846001715 P-loop; other site 1009846001716 Magnesium ion binding site [ion binding]; other site 1009846001717 putative ATP-dependent protease; Provisional; Region: PRK09862 1009846001718 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1009846001719 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1009846001720 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1009846001721 Membrane fusogenic activity; Region: BMFP; pfam04380 1009846001722 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1009846001723 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1009846001724 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1009846001725 Glutamate-cysteine ligase; Region: GshA; pfam08886 1009846001726 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 1009846001727 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1009846001728 active pocket/dimerization site; other site 1009846001729 active site 1009846001730 phosphorylation site [posttranslational modification] 1009846001731 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1009846001732 dimerization domain swap beta strand [polypeptide binding]; other site 1009846001733 regulatory protein interface [polypeptide binding]; other site 1009846001734 active site 1009846001735 regulatory phosphorylation site [posttranslational modification]; other site 1009846001736 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1009846001737 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1009846001738 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1009846001739 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1009846001740 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1009846001741 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1009846001742 ATP binding site [chemical binding]; other site 1009846001743 substrate interface [chemical binding]; other site 1009846001744 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1009846001745 C-terminal peptidase (prc); Region: prc; TIGR00225 1009846001746 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1009846001747 protein binding site [polypeptide binding]; other site 1009846001748 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1009846001749 Catalytic dyad [active] 1009846001750 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009846001751 catalytic core [active] 1009846001752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009846001753 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1009846001754 active site residue [active] 1009846001755 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1009846001756 GSH binding site [chemical binding]; other site 1009846001757 catalytic residues [active] 1009846001758 preprotein translocase subunit SecB; Validated; Region: PRK05751 1009846001759 SecA binding site; other site 1009846001760 Preprotein binding site; other site 1009846001761 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1009846001762 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1009846001763 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1009846001764 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1009846001765 putative ADP-ribose binding site [chemical binding]; other site 1009846001766 putative active site [active] 1009846001767 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1009846001768 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1009846001769 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1009846001770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846001771 S-adenosylmethionine binding site [chemical binding]; other site 1009846001772 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 1009846001773 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1009846001774 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 1009846001775 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1009846001776 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846001777 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1009846001778 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846001779 ligand binding site [chemical binding]; other site 1009846001780 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1009846001781 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1009846001782 Subunit I/III interface [polypeptide binding]; other site 1009846001783 D-pathway; other site 1009846001784 Subunit I/VIIc interface [polypeptide binding]; other site 1009846001785 Subunit I/IV interface [polypeptide binding]; other site 1009846001786 Subunit I/II interface [polypeptide binding]; other site 1009846001787 Low-spin heme (heme a) binding site [chemical binding]; other site 1009846001788 Subunit I/VIIa interface [polypeptide binding]; other site 1009846001789 Subunit I/VIa interface [polypeptide binding]; other site 1009846001790 Dimer interface; other site 1009846001791 Putative water exit pathway; other site 1009846001792 Binuclear center (heme a3/CuB) [ion binding]; other site 1009846001793 K-pathway; other site 1009846001794 Subunit I/Vb interface [polypeptide binding]; other site 1009846001795 Putative proton exit pathway; other site 1009846001796 Subunit I/VIb interface; other site 1009846001797 Subunit I/VIc interface [polypeptide binding]; other site 1009846001798 Electron transfer pathway; other site 1009846001799 Subunit I/VIIIb interface [polypeptide binding]; other site 1009846001800 Subunit I/VIIb interface [polypeptide binding]; other site 1009846001801 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1009846001802 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1009846001803 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1009846001804 Subunit III/VIIa interface [polypeptide binding]; other site 1009846001805 Phospholipid binding site [chemical binding]; other site 1009846001806 Subunit I/III interface [polypeptide binding]; other site 1009846001807 Subunit III/VIb interface [polypeptide binding]; other site 1009846001808 Subunit III/VIa interface; other site 1009846001809 Subunit III/Vb interface [polypeptide binding]; other site 1009846001810 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1009846001811 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1009846001812 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009846001813 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1009846001814 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1009846001815 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1009846001816 UbiA prenyltransferase family; Region: UbiA; pfam01040 1009846001817 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1009846001818 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846001819 Cu(I) binding site [ion binding]; other site 1009846001820 YCII-related domain; Region: YCII; cl00999 1009846001821 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1009846001822 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1009846001823 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846001824 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846001825 dimer interface [polypeptide binding]; other site 1009846001826 putative CheW interface [polypeptide binding]; other site 1009846001827 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1009846001828 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1009846001829 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1009846001830 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1009846001831 zinc binding site [ion binding]; other site 1009846001832 putative ligand binding site [chemical binding]; other site 1009846001833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846001834 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1009846001835 TM-ABC transporter signature motif; other site 1009846001836 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1009846001837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846001838 Walker A/P-loop; other site 1009846001839 ATP binding site [chemical binding]; other site 1009846001840 Q-loop/lid; other site 1009846001841 ABC transporter signature motif; other site 1009846001842 Walker B; other site 1009846001843 D-loop; other site 1009846001844 H-loop/switch region; other site 1009846001845 DNA Polymerase Y-family; Region: PolY_like; cd03468 1009846001846 active site 1009846001847 DNA binding site [nucleotide binding] 1009846001848 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1009846001849 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1009846001850 putative active site [active] 1009846001851 putative PHP Thumb interface [polypeptide binding]; other site 1009846001852 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1009846001853 generic binding surface II; other site 1009846001854 generic binding surface I; other site 1009846001855 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1009846001856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846001857 DNA-binding site [nucleotide binding]; DNA binding site 1009846001858 UTRA domain; Region: UTRA; pfam07702 1009846001859 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1009846001860 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1009846001861 active site 1009846001862 dimer interface [polypeptide binding]; other site 1009846001863 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1009846001864 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009846001865 dimer interface [polypeptide binding]; other site 1009846001866 active site 1009846001867 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009846001868 dimer interface [polypeptide binding]; other site 1009846001869 active site 1009846001870 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1009846001871 HPr interaction site; other site 1009846001872 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1009846001873 active site 1009846001874 phosphorylation site [posttranslational modification] 1009846001875 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1009846001876 dimerization domain swap beta strand [polypeptide binding]; other site 1009846001877 regulatory protein interface [polypeptide binding]; other site 1009846001878 active site 1009846001879 regulatory phosphorylation site [posttranslational modification]; other site 1009846001880 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1009846001881 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1009846001882 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1009846001883 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1009846001884 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1009846001885 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1009846001886 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1009846001887 active site turn [active] 1009846001888 phosphorylation site [posttranslational modification] 1009846001889 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1009846001890 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1009846001891 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1009846001892 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1009846001893 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1009846001894 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1009846001895 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1009846001896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846001897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846001898 DNA binding residues [nucleotide binding] 1009846001899 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1009846001900 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1009846001901 SnoaL-like domain; Region: SnoaL_3; pfam13474 1009846001902 2-isopropylmalate synthase; Validated; Region: PRK03739 1009846001903 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1009846001904 active site 1009846001905 catalytic residues [active] 1009846001906 metal binding site [ion binding]; metal-binding site 1009846001907 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1009846001908 glycosyl transferase family protein; Provisional; Region: PRK08136 1009846001909 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1009846001910 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1009846001911 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1009846001912 C-terminal domain interface [polypeptide binding]; other site 1009846001913 GSH binding site (G-site) [chemical binding]; other site 1009846001914 putative dimer interface [polypeptide binding]; other site 1009846001915 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1009846001916 dimer interface [polypeptide binding]; other site 1009846001917 N-terminal domain interface [polypeptide binding]; other site 1009846001918 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1009846001919 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1009846001920 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1009846001921 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1009846001922 P loop; other site 1009846001923 GTP binding site [chemical binding]; other site 1009846001924 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1009846001925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846001926 S-adenosylmethionine binding site [chemical binding]; other site 1009846001927 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1009846001928 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1009846001929 active site 1009846001930 (T/H)XGH motif; other site 1009846001931 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1009846001932 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1009846001933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846001934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846001935 homodimer interface [polypeptide binding]; other site 1009846001936 catalytic residue [active] 1009846001937 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1009846001938 putative active site [active] 1009846001939 catalytic residue [active] 1009846001940 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1009846001941 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1009846001942 5S rRNA interface [nucleotide binding]; other site 1009846001943 CTC domain interface [polypeptide binding]; other site 1009846001944 L16 interface [polypeptide binding]; other site 1009846001945 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1009846001946 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1009846001947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846001948 active site 1009846001949 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1009846001950 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1009846001951 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1009846001952 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1009846001953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846001954 TPR motif; other site 1009846001955 binding surface 1009846001956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846001957 binding surface 1009846001958 TPR motif; other site 1009846001959 TPR repeat; Region: TPR_11; pfam13414 1009846001960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846001961 binding surface 1009846001962 TPR motif; other site 1009846001963 TPR repeat; Region: TPR_11; pfam13414 1009846001964 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1009846001965 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1009846001966 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1009846001967 putative active site [active] 1009846001968 putative NTP binding site [chemical binding]; other site 1009846001969 putative nucleic acid binding site [nucleotide binding]; other site 1009846001970 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1009846001971 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1009846001972 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1009846001973 active site 1009846001974 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1009846001975 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1009846001976 DNA binding site [nucleotide binding] 1009846001977 catalytic residue [active] 1009846001978 H2TH interface [polypeptide binding]; other site 1009846001979 putative catalytic residues [active] 1009846001980 turnover-facilitating residue; other site 1009846001981 intercalation triad [nucleotide binding]; other site 1009846001982 8OG recognition residue [nucleotide binding]; other site 1009846001983 putative reading head residues; other site 1009846001984 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1009846001985 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1009846001986 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1009846001987 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1009846001988 minor groove reading motif; other site 1009846001989 helix-hairpin-helix signature motif; other site 1009846001990 substrate binding pocket [chemical binding]; other site 1009846001991 active site 1009846001992 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1009846001993 DNA binding and oxoG recognition site [nucleotide binding] 1009846001994 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1009846001995 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1009846001996 AAA domain; Region: AAA_18; pfam13238 1009846001997 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1009846001998 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1009846001999 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1009846002000 Hpr binding site; other site 1009846002001 active site 1009846002002 homohexamer subunit interaction site [polypeptide binding]; other site 1009846002003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1009846002004 active site 1009846002005 phosphorylation site [posttranslational modification] 1009846002006 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1009846002007 30S subunit binding site; other site 1009846002008 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1009846002009 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1009846002010 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1009846002011 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1009846002012 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1009846002013 Walker A/P-loop; other site 1009846002014 ATP binding site [chemical binding]; other site 1009846002015 Q-loop/lid; other site 1009846002016 ABC transporter signature motif; other site 1009846002017 Walker B; other site 1009846002018 D-loop; other site 1009846002019 H-loop/switch region; other site 1009846002020 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1009846002021 OstA-like protein; Region: OstA; pfam03968 1009846002022 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1009846002023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1009846002024 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 1009846002025 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1009846002026 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1009846002027 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1009846002028 putative active site [active] 1009846002029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1009846002030 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1009846002031 TrkA-N domain; Region: TrkA_N; pfam02254 1009846002032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846002033 active site 1009846002034 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846002035 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 1009846002036 nudix motif; other site 1009846002037 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1009846002038 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1009846002039 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1009846002040 putative active site [active] 1009846002041 putative substrate binding site [chemical binding]; other site 1009846002042 putative cosubstrate binding site; other site 1009846002043 catalytic site [active] 1009846002044 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1009846002045 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1009846002046 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1009846002047 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1009846002048 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1009846002049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846002051 putative substrate translocation pore; other site 1009846002052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1009846002053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1009846002054 dimer interface [polypeptide binding]; other site 1009846002055 ssDNA binding site [nucleotide binding]; other site 1009846002056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009846002057 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1009846002058 active site 1009846002059 SUMO-1 interface [polypeptide binding]; other site 1009846002060 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1009846002061 active site 1009846002062 DNA binding site [nucleotide binding] 1009846002063 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1009846002064 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846002065 P-loop; other site 1009846002066 Magnesium ion binding site [ion binding]; other site 1009846002067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846002068 Magnesium ion binding site [ion binding]; other site 1009846002069 Phasin protein; Region: Phasin_2; pfam09361 1009846002070 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 1009846002071 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846002072 dimer interface [polypeptide binding]; other site 1009846002073 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1009846002074 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1009846002075 NAD(P) binding site [chemical binding]; other site 1009846002076 homotetramer interface [polypeptide binding]; other site 1009846002077 homodimer interface [polypeptide binding]; other site 1009846002078 active site 1009846002079 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1009846002080 putative active site 1 [active] 1009846002081 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1009846002082 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1009846002083 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1009846002084 dimer interface [polypeptide binding]; other site 1009846002085 active site 1009846002086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1009846002087 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1009846002088 NodB motif; other site 1009846002089 active site 1009846002090 catalytic site [active] 1009846002091 metal binding site [ion binding]; metal-binding site 1009846002092 Predicted exporter [General function prediction only]; Region: COG4258 1009846002093 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1009846002094 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1009846002095 putative acyl-acceptor binding pocket; other site 1009846002096 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1009846002097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846002098 acyl-activating enzyme (AAE) consensus motif; other site 1009846002099 AMP binding site [chemical binding]; other site 1009846002100 active site 1009846002101 CoA binding site [chemical binding]; other site 1009846002102 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1009846002103 active site 2 [active] 1009846002104 dimer interface [polypeptide binding]; other site 1009846002105 active site 1 [active] 1009846002106 Predicted membrane protein [Function unknown]; Region: COG4648 1009846002107 acyl carrier protein; Provisional; Region: PRK09184 1009846002108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846002109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846002110 NAD(P) binding site [chemical binding]; other site 1009846002111 active site 1009846002112 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 1009846002113 homotrimer interaction site [polypeptide binding]; other site 1009846002114 putative active site [active] 1009846002115 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1009846002116 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1009846002117 Ligand binding site; other site 1009846002118 Putative Catalytic site; other site 1009846002119 DXD motif; other site 1009846002120 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1009846002121 L-lactate permease; Region: Lactate_perm; cl00701 1009846002122 glycolate transporter; Provisional; Region: PRK09695 1009846002123 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1009846002124 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1009846002125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1009846002126 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1009846002127 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1009846002128 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1009846002129 Cysteine-rich domain; Region: CCG; pfam02754 1009846002130 Cysteine-rich domain; Region: CCG; pfam02754 1009846002131 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846002132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846002133 DNA-binding site [nucleotide binding]; DNA binding site 1009846002134 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846002135 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1009846002136 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1009846002137 putative active site [active] 1009846002138 catalytic site [active] 1009846002139 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1009846002140 putative active site [active] 1009846002141 catalytic site [active] 1009846002142 aldolase II superfamily protein; Provisional; Region: PRK07044 1009846002143 intersubunit interface [polypeptide binding]; other site 1009846002144 active site 1009846002145 Zn2+ binding site [ion binding]; other site 1009846002146 CHRD domain; Region: CHRD; pfam07452 1009846002147 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846002148 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1009846002149 EcsC protein family; Region: EcsC; pfam12787 1009846002150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846002152 putative substrate translocation pore; other site 1009846002153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002154 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846002155 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1009846002156 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1009846002157 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1009846002158 conserved cys residue [active] 1009846002159 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1009846002160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1009846002161 dimer interface [polypeptide binding]; other site 1009846002162 active site 1009846002163 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846002164 substrate binding site [chemical binding]; other site 1009846002165 catalytic residue [active] 1009846002166 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846002167 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846002168 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846002169 putative active site [active] 1009846002170 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1009846002171 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1009846002172 active site 1009846002173 putative substrate binding pocket [chemical binding]; other site 1009846002174 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1009846002175 homotrimer interaction site [polypeptide binding]; other site 1009846002176 putative active site [active] 1009846002177 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1009846002178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1009846002179 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1009846002180 threonine dehydratase; Reviewed; Region: PRK09224 1009846002181 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1009846002182 tetramer interface [polypeptide binding]; other site 1009846002183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846002184 catalytic residue [active] 1009846002185 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1009846002186 putative Ile/Val binding site [chemical binding]; other site 1009846002187 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1009846002188 putative Ile/Val binding site [chemical binding]; other site 1009846002189 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 1009846002190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1009846002191 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846002192 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1009846002193 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1009846002194 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1009846002195 Cysteine-rich domain; Region: CCG; pfam02754 1009846002196 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 1009846002197 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1009846002198 nucleotide binding site/active site [active] 1009846002199 HIT family signature motif; other site 1009846002200 catalytic residue [active] 1009846002201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1009846002202 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1009846002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846002204 S-adenosylmethionine binding site [chemical binding]; other site 1009846002205 Tim44-like domain; Region: Tim44; pfam04280 1009846002206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1009846002207 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1009846002208 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1009846002209 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1009846002210 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1009846002211 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1009846002212 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1009846002213 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1009846002214 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1009846002215 dimer interface [polypeptide binding]; other site 1009846002216 anticodon binding site; other site 1009846002217 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1009846002218 homodimer interface [polypeptide binding]; other site 1009846002219 motif 1; other site 1009846002220 active site 1009846002221 motif 2; other site 1009846002222 GAD domain; Region: GAD; pfam02938 1009846002223 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1009846002224 motif 3; other site 1009846002225 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1009846002226 nudix motif; other site 1009846002227 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1009846002228 PLD-like domain; Region: PLDc_2; pfam13091 1009846002229 putative active site [active] 1009846002230 catalytic site [active] 1009846002231 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1009846002232 PLD-like domain; Region: PLDc_2; pfam13091 1009846002233 putative active site [active] 1009846002234 catalytic site [active] 1009846002235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846002236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846002237 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1009846002238 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1009846002239 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1009846002240 FAD binding site [chemical binding]; other site 1009846002241 substrate binding site [chemical binding]; other site 1009846002242 catalytic residues [active] 1009846002243 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1009846002244 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1009846002245 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846002246 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846002247 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1009846002248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846002249 substrate binding site [chemical binding]; other site 1009846002250 oxyanion hole (OAH) forming residues; other site 1009846002251 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1009846002252 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846002253 dimer interface [polypeptide binding]; other site 1009846002254 active site 1009846002255 enoyl-CoA hydratase; Provisional; Region: PRK06688 1009846002256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846002257 substrate binding site [chemical binding]; other site 1009846002258 oxyanion hole (OAH) forming residues; other site 1009846002259 trimer interface [polypeptide binding]; other site 1009846002260 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1009846002261 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1009846002262 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1009846002263 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1009846002264 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1009846002265 D-pathway; other site 1009846002266 Putative ubiquinol binding site [chemical binding]; other site 1009846002267 Low-spin heme (heme b) binding site [chemical binding]; other site 1009846002268 Putative water exit pathway; other site 1009846002269 Binuclear center (heme o3/CuB) [ion binding]; other site 1009846002270 K-pathway; other site 1009846002271 Putative proton exit pathway; other site 1009846002272 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1009846002273 Subunit I/III interface [polypeptide binding]; other site 1009846002274 Subunit III/IV interface [polypeptide binding]; other site 1009846002275 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1009846002276 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846002277 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1009846002278 putative di-iron ligands [ion binding]; other site 1009846002279 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1009846002280 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 1009846002281 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1009846002282 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846002283 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1009846002284 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1009846002285 Walker A/P-loop; other site 1009846002286 ATP binding site [chemical binding]; other site 1009846002287 Q-loop/lid; other site 1009846002288 ABC transporter signature motif; other site 1009846002289 Walker B; other site 1009846002290 D-loop; other site 1009846002291 H-loop/switch region; other site 1009846002292 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1009846002293 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1009846002294 Substrate binding site; other site 1009846002295 metal-binding site 1009846002296 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1009846002297 Phosphotransferase enzyme family; Region: APH; pfam01636 1009846002298 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1009846002299 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1009846002300 SurA N-terminal domain; Region: SurA_N; pfam09312 1009846002301 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1009846002302 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1009846002303 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 1009846002304 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1009846002305 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1009846002306 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1009846002307 EamA-like transporter family; Region: EamA; pfam00892 1009846002308 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846002309 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1009846002310 dimer interface [polypeptide binding]; other site 1009846002311 active site 1009846002312 metal binding site [ion binding]; metal-binding site 1009846002313 glutathione binding site [chemical binding]; other site 1009846002314 Protein of unknown function DUF45; Region: DUF45; pfam01863 1009846002315 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009846002316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009846002317 putative acyl-acceptor binding pocket; other site 1009846002318 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1009846002319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846002320 active site 1009846002321 motif I; other site 1009846002322 motif II; other site 1009846002323 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1009846002324 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1009846002325 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1009846002326 dimer interface [polypeptide binding]; other site 1009846002327 motif 1; other site 1009846002328 active site 1009846002329 motif 2; other site 1009846002330 motif 3; other site 1009846002331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846002332 TPR repeat; Region: TPR_11; pfam13414 1009846002333 binding surface 1009846002334 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1009846002335 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1009846002336 putative active site [active] 1009846002337 catalytic triad [active] 1009846002338 putative dimer interface [polypeptide binding]; other site 1009846002339 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1009846002340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1009846002341 Transporter associated domain; Region: CorC_HlyC; smart01091 1009846002342 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1009846002343 putative active site pocket [active] 1009846002344 dimerization interface [polypeptide binding]; other site 1009846002345 putative catalytic residue [active] 1009846002346 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 1009846002347 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1009846002348 PhoH-like protein; Region: PhoH; pfam02562 1009846002349 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1009846002350 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1009846002351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846002352 FeS/SAM binding site; other site 1009846002353 TRAM domain; Region: TRAM; pfam01938 1009846002354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846002355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846002356 non-specific DNA binding site [nucleotide binding]; other site 1009846002357 salt bridge; other site 1009846002358 sequence-specific DNA binding site [nucleotide binding]; other site 1009846002359 Cupin domain; Region: Cupin_2; pfam07883 1009846002360 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1009846002361 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1009846002362 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1009846002363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846002364 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1009846002365 amphipathic channel; other site 1009846002366 Asn-Pro-Ala signature motifs; other site 1009846002367 glycerol kinase; Provisional; Region: glpK; PRK00047 1009846002368 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1009846002369 N- and C-terminal domain interface [polypeptide binding]; other site 1009846002370 active site 1009846002371 MgATP binding site [chemical binding]; other site 1009846002372 catalytic site [active] 1009846002373 metal binding site [ion binding]; metal-binding site 1009846002374 glycerol binding site [chemical binding]; other site 1009846002375 homotetramer interface [polypeptide binding]; other site 1009846002376 homodimer interface [polypeptide binding]; other site 1009846002377 FBP binding site [chemical binding]; other site 1009846002378 protein IIAGlc interface [polypeptide binding]; other site 1009846002379 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1009846002380 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1009846002381 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1009846002382 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1009846002383 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1009846002384 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1009846002385 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1009846002386 dinuclear metal binding motif [ion binding]; other site 1009846002387 helicase 45; Provisional; Region: PTZ00424 1009846002388 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1009846002389 ATP binding site [chemical binding]; other site 1009846002390 Mg++ binding site [ion binding]; other site 1009846002391 motif III; other site 1009846002392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846002393 nucleotide binding region [chemical binding]; other site 1009846002394 ATP-binding site [chemical binding]; other site 1009846002395 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846002396 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846002397 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846002398 Cytochrome c; Region: Cytochrom_C; cl11414 1009846002399 Cytochrome c; Region: Cytochrom_C; cl11414 1009846002400 Copper resistance protein D; Region: CopD; pfam05425 1009846002401 galactonate dehydratase; Provisional; Region: PRK14017 1009846002402 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1009846002403 putative active site pocket [active] 1009846002404 putative metal binding site [ion binding]; other site 1009846002405 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846002406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846002407 DNA-binding site [nucleotide binding]; DNA binding site 1009846002408 FCD domain; Region: FCD; pfam07729 1009846002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1009846002410 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1009846002411 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1009846002412 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1009846002413 Transglycosylase; Region: Transgly; pfam00912 1009846002414 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009846002415 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846002416 putative effector binding pocket; other site 1009846002417 Cupin domain; Region: Cupin_2; cl17218 1009846002418 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1009846002419 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1009846002420 conserved cys residue [active] 1009846002421 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846002422 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846002423 conserved cys residue [active] 1009846002424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846002425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846002426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846002427 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846002428 putative effector binding pocket; other site 1009846002429 putative dimerization interface [polypeptide binding]; other site 1009846002430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002431 putative substrate translocation pore; other site 1009846002432 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1009846002433 HAMP domain; Region: HAMP; pfam00672 1009846002434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846002435 dimer interface [polypeptide binding]; other site 1009846002436 phosphorylation site [posttranslational modification] 1009846002437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846002438 ATP binding site [chemical binding]; other site 1009846002439 Mg2+ binding site [ion binding]; other site 1009846002440 G-X-G motif; other site 1009846002441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846002442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846002443 active site 1009846002444 phosphorylation site [posttranslational modification] 1009846002445 intermolecular recognition site; other site 1009846002446 dimerization interface [polypeptide binding]; other site 1009846002447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846002448 DNA binding site [nucleotide binding] 1009846002449 recombinase A; Provisional; Region: recA; PRK09354 1009846002450 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1009846002451 hexamer interface [polypeptide binding]; other site 1009846002452 Walker A motif; other site 1009846002453 ATP binding site [chemical binding]; other site 1009846002454 Walker B motif; other site 1009846002455 recombination regulator RecX; Provisional; Region: recX; PRK14136 1009846002456 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1009846002457 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1009846002458 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1009846002459 CoA-ligase; Region: Ligase_CoA; pfam00549 1009846002460 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1009846002461 CoA binding domain; Region: CoA_binding; smart00881 1009846002462 CoA-ligase; Region: Ligase_CoA; pfam00549 1009846002463 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1009846002464 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1009846002465 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1009846002466 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1009846002467 O-Antigen ligase; Region: Wzy_C; pfam04932 1009846002468 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 1009846002469 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1009846002470 trimer interface [polypeptide binding]; other site 1009846002471 dimer interface [polypeptide binding]; other site 1009846002472 putative active site [active] 1009846002473 Peptidase family M48; Region: Peptidase_M48; pfam01435 1009846002474 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 1009846002475 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1009846002476 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1009846002477 SnoaL-like domain; Region: SnoaL_3; pfam13474 1009846002478 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1009846002479 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1009846002480 putative active site [active] 1009846002481 Zinc-finger domain; Region: zf-CHCC; cl01821 1009846002482 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1009846002483 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1009846002484 homodimer interface [polypeptide binding]; other site 1009846002485 substrate-cofactor binding pocket; other site 1009846002486 catalytic residue [active] 1009846002487 AzlC protein; Region: AzlC; cl00570 1009846002488 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1009846002489 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1009846002490 Phosphoglycerate kinase; Region: PGK; pfam00162 1009846002491 substrate binding site [chemical binding]; other site 1009846002492 hinge regions; other site 1009846002493 ADP binding site [chemical binding]; other site 1009846002494 catalytic site [active] 1009846002495 pyruvate kinase; Provisional; Region: PRK05826 1009846002496 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1009846002497 domain interfaces; other site 1009846002498 active site 1009846002499 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1009846002500 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1009846002501 intersubunit interface [polypeptide binding]; other site 1009846002502 active site 1009846002503 zinc binding site [ion binding]; other site 1009846002504 Na+ binding site [ion binding]; other site 1009846002505 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1009846002506 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1009846002507 ATP binding site [chemical binding]; other site 1009846002508 active site 1009846002509 substrate binding site [chemical binding]; other site 1009846002510 AIR carboxylase; Region: AIRC; cl00310 1009846002511 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1009846002512 ATP-grasp domain; Region: ATP-grasp; pfam02222 1009846002513 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1009846002514 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1009846002515 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1009846002516 active site 1009846002517 catalytic triad [active] 1009846002518 oxyanion hole [active] 1009846002519 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1009846002520 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1009846002521 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1009846002522 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1009846002523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846002524 active site 1009846002525 phosphorylation site [posttranslational modification] 1009846002526 intermolecular recognition site; other site 1009846002527 dimerization interface [polypeptide binding]; other site 1009846002528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846002529 DNA binding site [nucleotide binding] 1009846002530 sensor protein QseC; Provisional; Region: PRK10337 1009846002531 HAMP domain; Region: HAMP; pfam00672 1009846002532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846002533 ATP binding site [chemical binding]; other site 1009846002534 Mg2+ binding site [ion binding]; other site 1009846002535 G-X-G motif; other site 1009846002536 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1009846002537 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1009846002538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846002539 protein binding site [polypeptide binding]; other site 1009846002540 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846002541 protein binding site [polypeptide binding]; other site 1009846002542 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1009846002543 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1009846002544 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1009846002545 hydrophobic ligand binding site; other site 1009846002546 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1009846002547 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846002548 conserved cys residue [active] 1009846002549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846002550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846002551 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846002552 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1009846002553 catalytic triad [active] 1009846002554 conserved cis-peptide bond; other site 1009846002555 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1009846002556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846002557 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1009846002558 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1009846002559 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846002560 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846002561 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1009846002562 Protein export membrane protein; Region: SecD_SecF; cl14618 1009846002563 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1009846002564 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1009846002565 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1009846002566 xanthine permease; Region: pbuX; TIGR03173 1009846002567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009846002568 nucleotide binding site [chemical binding]; other site 1009846002569 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846002570 S-formylglutathione hydrolase; Region: PLN02442 1009846002571 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1009846002572 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1009846002573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1009846002574 ABC-ATPase subunit interface; other site 1009846002575 dimer interface [polypeptide binding]; other site 1009846002576 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1009846002577 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1009846002578 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1009846002579 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1009846002580 metal binding site [ion binding]; metal-binding site 1009846002581 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1009846002582 metal binding site 2 [ion binding]; metal-binding site 1009846002583 putative DNA binding helix; other site 1009846002584 metal binding site 1 [ion binding]; metal-binding site 1009846002585 dimer interface [polypeptide binding]; other site 1009846002586 structural Zn2+ binding site [ion binding]; other site 1009846002587 sorbitol dehydrogenase; Provisional; Region: PRK07067 1009846002588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846002589 NAD(P) binding site [chemical binding]; other site 1009846002590 active site 1009846002591 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1009846002592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846002593 substrate binding site [chemical binding]; other site 1009846002594 ATP binding site [chemical binding]; other site 1009846002595 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 1009846002596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009846002597 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846002598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846002599 dimer interface [polypeptide binding]; other site 1009846002600 conserved gate region; other site 1009846002601 putative PBP binding loops; other site 1009846002602 ABC-ATPase subunit interface; other site 1009846002603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009846002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846002605 dimer interface [polypeptide binding]; other site 1009846002606 conserved gate region; other site 1009846002607 putative PBP binding loops; other site 1009846002608 ABC-ATPase subunit interface; other site 1009846002609 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1009846002610 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1009846002611 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1009846002612 Walker A/P-loop; other site 1009846002613 ATP binding site [chemical binding]; other site 1009846002614 Q-loop/lid; other site 1009846002615 ABC transporter signature motif; other site 1009846002616 Walker B; other site 1009846002617 D-loop; other site 1009846002618 H-loop/switch region; other site 1009846002619 TOBE domain; Region: TOBE; pfam03459 1009846002620 TOBE domain; Region: TOBE_2; pfam08402 1009846002621 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1009846002622 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1009846002623 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1009846002624 N- and C-terminal domain interface [polypeptide binding]; other site 1009846002625 D-xylulose kinase; Region: XylB; TIGR01312 1009846002626 active site 1009846002627 MgATP binding site [chemical binding]; other site 1009846002628 catalytic site [active] 1009846002629 metal binding site [ion binding]; metal-binding site 1009846002630 xylulose binding site [chemical binding]; other site 1009846002631 homodimer interface [polypeptide binding]; other site 1009846002632 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1009846002633 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1009846002634 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1009846002635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846002636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846002637 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1009846002638 putative dimerization interface [polypeptide binding]; other site 1009846002639 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1009846002640 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846002641 PYR/PP interface [polypeptide binding]; other site 1009846002642 dimer interface [polypeptide binding]; other site 1009846002643 TPP binding site [chemical binding]; other site 1009846002644 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846002645 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1009846002646 TPP-binding site [chemical binding]; other site 1009846002647 dimer interface [polypeptide binding]; other site 1009846002648 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846002649 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846002650 NAD(P) binding site [chemical binding]; other site 1009846002651 catalytic residues [active] 1009846002652 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1009846002653 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009846002654 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009846002655 benzoate transport; Region: 2A0115; TIGR00895 1009846002656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002657 putative substrate translocation pore; other site 1009846002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002659 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1009846002660 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1009846002661 kynureninase; Region: kynureninase; TIGR01814 1009846002662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846002663 catalytic residue [active] 1009846002664 arylformamidase; Region: trp_arylform; TIGR03035 1009846002665 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846002666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846002667 putative DNA binding site [nucleotide binding]; other site 1009846002668 putative Zn2+ binding site [ion binding]; other site 1009846002669 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846002670 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1009846002671 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1009846002672 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1009846002673 Protein of unknown function DUF72; Region: DUF72; pfam01904 1009846002674 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1009846002675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846002676 S-adenosylmethionine binding site [chemical binding]; other site 1009846002677 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1009846002678 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1009846002679 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1009846002680 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1009846002681 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1009846002682 putative ATP binding site [chemical binding]; other site 1009846002683 putative substrate interface [chemical binding]; other site 1009846002684 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1009846002685 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009846002686 catalytic residues [active] 1009846002687 Pirin-related protein [General function prediction only]; Region: COG1741 1009846002688 Pirin; Region: Pirin; pfam02678 1009846002689 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1009846002690 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1009846002691 EamA-like transporter family; Region: EamA; pfam00892 1009846002692 EamA-like transporter family; Region: EamA; pfam00892 1009846002693 AMIN domain; Region: AMIN; pfam11741 1009846002694 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1009846002695 active site 1009846002696 metal binding site [ion binding]; metal-binding site 1009846002697 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1009846002698 epoxyqueuosine reductase; Region: TIGR00276 1009846002699 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1009846002700 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1009846002701 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1009846002702 DNA binding site [nucleotide binding] 1009846002703 active site 1009846002704 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1009846002705 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1009846002706 active site 1009846002707 Int/Topo IB signature motif; other site 1009846002708 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1009846002709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846002710 acyl-activating enzyme (AAE) consensus motif; other site 1009846002711 AMP binding site [chemical binding]; other site 1009846002712 active site 1009846002713 CoA binding site [chemical binding]; other site 1009846002714 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1009846002715 putative deacylase active site [active] 1009846002716 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1009846002717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1009846002718 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1009846002719 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1009846002720 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846002721 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1009846002722 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1009846002723 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1009846002724 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1009846002725 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 1009846002726 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1009846002727 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1009846002728 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1009846002729 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1009846002730 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1009846002731 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1009846002732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846002733 NAD(P) binding site [chemical binding]; other site 1009846002734 active site 1009846002735 adenylate kinase; Reviewed; Region: adk; PRK00279 1009846002736 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1009846002737 AMP-binding site [chemical binding]; other site 1009846002738 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1009846002739 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1009846002740 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1009846002741 Ligand binding site; other site 1009846002742 oligomer interface; other site 1009846002743 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1009846002744 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 1009846002745 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1009846002746 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1009846002747 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1009846002748 generic binding surface II; other site 1009846002749 generic binding surface I; other site 1009846002750 superoxide dismutase; Provisional; Region: PRK10543 1009846002751 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1009846002752 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1009846002753 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1009846002754 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1009846002755 Chromate transporter; Region: Chromate_transp; pfam02417 1009846002756 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1009846002757 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846002758 ligand binding site [chemical binding]; other site 1009846002759 flexible hinge region; other site 1009846002760 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009846002761 putative switch regulator; other site 1009846002762 non-specific DNA interactions [nucleotide binding]; other site 1009846002763 DNA binding site [nucleotide binding] 1009846002764 sequence specific DNA binding site [nucleotide binding]; other site 1009846002765 putative cAMP binding site [chemical binding]; other site 1009846002766 Predicted membrane protein [Function unknown]; Region: COG4539 1009846002767 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1009846002768 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009846002769 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009846002770 tellurite resistance protein TehB; Provisional; Region: PRK11207 1009846002771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1009846002772 S-adenosylmethionine binding site [chemical binding]; other site 1009846002773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846002774 putative transporter; Provisional; Region: PRK10504 1009846002775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846002776 putative substrate translocation pore; other site 1009846002777 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1009846002778 MerR family regulatory protein; Region: MerR; pfam00376 1009846002779 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1009846002780 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1009846002781 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1009846002782 oxalacetate binding site [chemical binding]; other site 1009846002783 citrylCoA binding site [chemical binding]; other site 1009846002784 coenzyme A binding site [chemical binding]; other site 1009846002785 catalytic triad [active] 1009846002786 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846002787 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846002788 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1009846002789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846002790 DNA-binding site [nucleotide binding]; DNA binding site 1009846002791 UTRA domain; Region: UTRA; pfam07702 1009846002792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846002793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846002794 active site 1009846002795 catalytic tetrad [active] 1009846002796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846002797 active site 1009846002798 phosphorylation site [posttranslational modification] 1009846002799 intermolecular recognition site; other site 1009846002800 High-affinity nickel-transport protein; Region: NicO; cl00964 1009846002801 elongation factor G; Reviewed; Region: PRK00007 1009846002802 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1009846002803 G1 box; other site 1009846002804 putative GEF interaction site [polypeptide binding]; other site 1009846002805 GTP/Mg2+ binding site [chemical binding]; other site 1009846002806 Switch I region; other site 1009846002807 G2 box; other site 1009846002808 G3 box; other site 1009846002809 Switch II region; other site 1009846002810 G4 box; other site 1009846002811 G5 box; other site 1009846002812 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1009846002813 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1009846002814 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1009846002815 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1009846002816 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1009846002817 pseudouridine synthase; Region: TIGR00093 1009846002818 active site 1009846002819 isocitrate dehydrogenase; Validated; Region: PRK07362 1009846002820 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1009846002821 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1009846002822 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1009846002823 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1009846002824 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1009846002825 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1009846002826 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846002827 DNA-binding site [nucleotide binding]; DNA binding site 1009846002828 RNA-binding motif; other site 1009846002829 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1009846002830 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1009846002831 Clp amino terminal domain; Region: Clp_N; pfam02861 1009846002832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846002833 Walker A motif; other site 1009846002834 ATP binding site [chemical binding]; other site 1009846002835 Walker B motif; other site 1009846002836 arginine finger; other site 1009846002837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846002838 Walker A motif; other site 1009846002839 ATP binding site [chemical binding]; other site 1009846002840 Walker B motif; other site 1009846002841 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1009846002842 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009846002843 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1009846002844 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846002845 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846002846 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846002847 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1009846002848 trimer interface [polypeptide binding]; other site 1009846002849 active site 1009846002850 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1009846002851 Flavoprotein; Region: Flavoprotein; pfam02441 1009846002852 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1009846002853 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1009846002854 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1009846002855 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009846002856 active site 1009846002857 HIGH motif; other site 1009846002858 nucleotide binding site [chemical binding]; other site 1009846002859 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1009846002860 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1009846002861 active site 1009846002862 KMSKS motif; other site 1009846002863 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1009846002864 tRNA binding surface [nucleotide binding]; other site 1009846002865 anticodon binding site; other site 1009846002866 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1009846002867 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1009846002868 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1009846002869 active site 1009846002870 Riboflavin kinase; Region: Flavokinase; smart00904 1009846002871 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1009846002872 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1009846002873 active site 1009846002874 substrate binding site [chemical binding]; other site 1009846002875 cosubstrate binding site; other site 1009846002876 catalytic site [active] 1009846002877 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1009846002878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846002879 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846002880 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846002881 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1009846002882 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846002883 Di-iron ligands [ion binding]; other site 1009846002884 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1009846002885 quinolinate synthetase; Provisional; Region: PRK09375 1009846002886 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 1009846002887 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1009846002888 dimerization interface [polypeptide binding]; other site 1009846002889 active site 1009846002890 L-aspartate oxidase; Provisional; Region: PRK09077 1009846002891 L-aspartate oxidase; Provisional; Region: PRK06175 1009846002892 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1009846002893 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1009846002894 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1009846002895 hypothetical protein; Reviewed; Region: PRK00024 1009846002896 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1009846002897 MPN+ (JAMM) motif; other site 1009846002898 Zinc-binding site [ion binding]; other site 1009846002899 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009846002900 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1009846002901 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1009846002902 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1009846002903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846002904 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846002905 TM-ABC transporter signature motif; other site 1009846002906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846002907 TM-ABC transporter signature motif; other site 1009846002908 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846002909 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846002910 Walker A/P-loop; other site 1009846002911 ATP binding site [chemical binding]; other site 1009846002912 Q-loop/lid; other site 1009846002913 ABC transporter signature motif; other site 1009846002914 Walker B; other site 1009846002915 D-loop; other site 1009846002916 H-loop/switch region; other site 1009846002917 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846002918 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846002919 Walker A/P-loop; other site 1009846002920 ATP binding site [chemical binding]; other site 1009846002921 Q-loop/lid; other site 1009846002922 ABC transporter signature motif; other site 1009846002923 Walker B; other site 1009846002924 D-loop; other site 1009846002925 H-loop/switch region; other site 1009846002926 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1009846002927 putative acetyltransferase; Provisional; Region: PRK03624 1009846002928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846002929 Coenzyme A binding pocket [chemical binding]; other site 1009846002930 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1009846002931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846002932 inhibitor-cofactor binding pocket; inhibition site 1009846002933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846002934 catalytic residue [active] 1009846002935 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1009846002936 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846002937 catalytic loop [active] 1009846002938 iron binding site [ion binding]; other site 1009846002939 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1009846002940 FAD binding pocket [chemical binding]; other site 1009846002941 FAD binding motif [chemical binding]; other site 1009846002942 phosphate binding motif [ion binding]; other site 1009846002943 beta-alpha-beta structure motif; other site 1009846002944 NAD binding pocket [chemical binding]; other site 1009846002945 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1009846002946 putative NAD(P) binding site [chemical binding]; other site 1009846002947 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846002948 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1009846002949 RNA binding surface [nucleotide binding]; other site 1009846002950 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1009846002951 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1009846002952 active site 1009846002953 uracil binding [chemical binding]; other site 1009846002954 CopC domain; Region: CopC; pfam04234 1009846002955 DinB superfamily; Region: DinB_2; pfam12867 1009846002956 short chain dehydrogenase; Provisional; Region: PRK12744 1009846002957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846002958 NAD(P) binding site [chemical binding]; other site 1009846002959 active site 1009846002960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846002962 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846002963 putative effector binding pocket; other site 1009846002964 putative dimerization interface [polypeptide binding]; other site 1009846002965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846002966 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1009846002967 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846002968 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1009846002969 putative ligand binding site [chemical binding]; other site 1009846002970 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 1009846002971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846002972 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1009846002973 substrate binding site [chemical binding]; other site 1009846002974 dimerization interface [polypeptide binding]; other site 1009846002975 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1009846002976 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846002977 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846002978 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1009846002979 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1009846002980 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1009846002981 Active Sites [active] 1009846002982 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1009846002983 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1009846002984 Active Sites [active] 1009846002985 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1009846002986 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1009846002987 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1009846002988 CysD dimerization site [polypeptide binding]; other site 1009846002989 G1 box; other site 1009846002990 putative GEF interaction site [polypeptide binding]; other site 1009846002991 GTP/Mg2+ binding site [chemical binding]; other site 1009846002992 Switch I region; other site 1009846002993 G2 box; other site 1009846002994 G3 box; other site 1009846002995 Switch II region; other site 1009846002996 G4 box; other site 1009846002997 G5 box; other site 1009846002998 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1009846002999 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1009846003000 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1009846003001 active site 1009846003002 SAM binding site [chemical binding]; other site 1009846003003 homodimer interface [polypeptide binding]; other site 1009846003004 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1009846003005 putative active site [active] 1009846003006 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1009846003007 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1009846003008 Predicted permeases [General function prediction only]; Region: COG0795 1009846003009 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1009846003010 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1009846003011 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1009846003012 interface (dimer of trimers) [polypeptide binding]; other site 1009846003013 Substrate-binding/catalytic site; other site 1009846003014 Zn-binding sites [ion binding]; other site 1009846003015 DNA polymerase III subunit chi; Validated; Region: PRK05728 1009846003016 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 1009846003017 Cytochrome c; Region: Cytochrom_C; cl11414 1009846003018 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1009846003019 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1009846003020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846003021 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 1009846003022 putative dimerization interface [polypeptide binding]; other site 1009846003023 putative substrate binding pocket [chemical binding]; other site 1009846003024 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1009846003025 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1009846003026 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1009846003027 Cell division protein ZapA; Region: ZapA; pfam05164 1009846003028 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1009846003029 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1009846003030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1009846003031 ABC-ATPase subunit interface; other site 1009846003032 dimer interface [polypeptide binding]; other site 1009846003033 putative PBP binding regions; other site 1009846003034 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1009846003035 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1009846003036 Walker A/P-loop; other site 1009846003037 ATP binding site [chemical binding]; other site 1009846003038 Q-loop/lid; other site 1009846003039 ABC transporter signature motif; other site 1009846003040 Walker B; other site 1009846003041 D-loop; other site 1009846003042 H-loop/switch region; other site 1009846003043 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1009846003044 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1009846003045 putative dimer interface [polypeptide binding]; other site 1009846003046 active site pocket [active] 1009846003047 putative cataytic base [active] 1009846003048 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1009846003049 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009846003050 catalytic core [active] 1009846003051 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1009846003052 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1009846003053 cobalamin binding residues [chemical binding]; other site 1009846003054 putative BtuC binding residues; other site 1009846003055 dimer interface [polypeptide binding]; other site 1009846003056 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 1009846003057 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1009846003058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846003059 catalytic residue [active] 1009846003060 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1009846003061 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1009846003062 homotrimer interface [polypeptide binding]; other site 1009846003063 Walker A motif; other site 1009846003064 GTP binding site [chemical binding]; other site 1009846003065 Walker B motif; other site 1009846003066 cobyric acid synthase; Provisional; Region: PRK00784 1009846003067 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846003068 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1009846003069 catalytic triad [active] 1009846003070 DoxX; Region: DoxX; pfam07681 1009846003071 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1009846003072 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846003073 P-loop; other site 1009846003074 Magnesium ion binding site [ion binding]; other site 1009846003075 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1009846003076 tetramerization interface [polypeptide binding]; other site 1009846003077 active site 1009846003078 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1009846003079 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1009846003080 active site 1009846003081 ATP-binding site [chemical binding]; other site 1009846003082 pantoate-binding site; other site 1009846003083 HXXH motif; other site 1009846003084 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1009846003085 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 1009846003086 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1009846003087 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846003088 Surface antigen; Region: Bac_surface_Ag; pfam01103 1009846003089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1009846003090 Family of unknown function (DUF490); Region: DUF490; pfam04357 1009846003091 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1009846003092 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1009846003093 active site 1009846003094 HIGH motif; other site 1009846003095 KMSKS motif; other site 1009846003096 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1009846003097 tRNA binding surface [nucleotide binding]; other site 1009846003098 anticodon binding site; other site 1009846003099 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1009846003100 dimer interface [polypeptide binding]; other site 1009846003101 putative tRNA-binding site [nucleotide binding]; other site 1009846003102 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1009846003103 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846003104 ligand binding site [chemical binding]; other site 1009846003105 Domain of unknown function DUF59; Region: DUF59; pfam01883 1009846003106 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1009846003107 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1009846003108 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1009846003109 E-class dimer interface [polypeptide binding]; other site 1009846003110 P-class dimer interface [polypeptide binding]; other site 1009846003111 active site 1009846003112 Cu2+ binding site [ion binding]; other site 1009846003113 Zn2+ binding site [ion binding]; other site 1009846003114 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1009846003115 trimer interface [polypeptide binding]; other site 1009846003116 active site 1009846003117 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1009846003118 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1009846003119 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846003120 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846003121 catalytic residue [active] 1009846003122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1009846003123 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1009846003124 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1009846003125 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1009846003126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846003127 motif II; other site 1009846003128 argininosuccinate lyase; Provisional; Region: PRK00855 1009846003129 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1009846003130 active sites [active] 1009846003131 tetramer interface [polypeptide binding]; other site 1009846003132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846003133 non-specific DNA binding site [nucleotide binding]; other site 1009846003134 salt bridge; other site 1009846003135 sequence-specific DNA binding site [nucleotide binding]; other site 1009846003136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846003137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846003138 S-adenosylmethionine binding site [chemical binding]; other site 1009846003139 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1009846003140 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1009846003141 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1009846003142 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1009846003143 domain interfaces; other site 1009846003144 active site 1009846003145 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 1009846003146 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1009846003147 active site 1009846003148 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1009846003149 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1009846003150 HemY protein N-terminus; Region: HemY_N; pfam07219 1009846003151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846003152 TPR motif; other site 1009846003153 binding surface 1009846003154 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1009846003155 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1009846003156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846003157 putative substrate translocation pore; other site 1009846003158 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 1009846003159 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1009846003160 putative NAD(P) binding site [chemical binding]; other site 1009846003161 active site 1009846003162 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846003163 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1009846003164 NAD(P) binding site [chemical binding]; other site 1009846003165 catalytic residues [active] 1009846003166 catalytic residues [active] 1009846003167 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1009846003168 dimer interface [polypeptide binding]; other site 1009846003169 substrate binding site [chemical binding]; other site 1009846003170 metal binding sites [ion binding]; metal-binding site 1009846003171 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1009846003172 GIY-YIG motif/motif A; other site 1009846003173 putative active site [active] 1009846003174 putative metal binding site [ion binding]; other site 1009846003175 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1009846003176 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1009846003177 NAD synthetase; Provisional; Region: PRK13981 1009846003178 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1009846003179 multimer interface [polypeptide binding]; other site 1009846003180 active site 1009846003181 catalytic triad [active] 1009846003182 protein interface 1 [polypeptide binding]; other site 1009846003183 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1009846003184 homodimer interface [polypeptide binding]; other site 1009846003185 NAD binding pocket [chemical binding]; other site 1009846003186 ATP binding pocket [chemical binding]; other site 1009846003187 Mg binding site [ion binding]; other site 1009846003188 active-site loop [active] 1009846003189 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1009846003190 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1009846003191 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846003192 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846003193 trimer interface [polypeptide binding]; other site 1009846003194 eyelet of channel; other site 1009846003195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846003196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846003197 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 1009846003198 putative substrate binding pocket [chemical binding]; other site 1009846003199 dimerization interface [polypeptide binding]; other site 1009846003200 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846003201 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1009846003202 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846003203 Walker A/P-loop; other site 1009846003204 ATP binding site [chemical binding]; other site 1009846003205 Q-loop/lid; other site 1009846003206 ABC transporter signature motif; other site 1009846003207 Walker B; other site 1009846003208 D-loop; other site 1009846003209 H-loop/switch region; other site 1009846003210 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846003212 dimer interface [polypeptide binding]; other site 1009846003213 conserved gate region; other site 1009846003214 putative PBP binding loops; other site 1009846003215 ABC-ATPase subunit interface; other site 1009846003216 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846003217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846003218 dimer interface [polypeptide binding]; other site 1009846003219 conserved gate region; other site 1009846003220 putative PBP binding loops; other site 1009846003221 ABC-ATPase subunit interface; other site 1009846003222 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1009846003223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846003224 substrate binding pocket [chemical binding]; other site 1009846003225 membrane-bound complex binding site; other site 1009846003226 hinge residues; other site 1009846003227 Pirin-related protein [General function prediction only]; Region: COG1741 1009846003228 Pirin; Region: Pirin; pfam02678 1009846003229 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1009846003230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846003231 DNA binding site [nucleotide binding] 1009846003232 HAMP domain; Region: HAMP; pfam00672 1009846003233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846003234 dimer interface [polypeptide binding]; other site 1009846003235 phosphorylation site [posttranslational modification] 1009846003236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003237 ATP binding site [chemical binding]; other site 1009846003238 Mg2+ binding site [ion binding]; other site 1009846003239 G-X-G motif; other site 1009846003240 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1009846003241 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1009846003242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846003243 dimer interface [polypeptide binding]; other site 1009846003244 conserved gate region; other site 1009846003245 putative PBP binding loops; other site 1009846003246 ABC-ATPase subunit interface; other site 1009846003247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846003248 dimer interface [polypeptide binding]; other site 1009846003249 conserved gate region; other site 1009846003250 putative PBP binding loops; other site 1009846003251 ABC-ATPase subunit interface; other site 1009846003252 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009846003253 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846003254 Walker A/P-loop; other site 1009846003255 ATP binding site [chemical binding]; other site 1009846003256 Q-loop/lid; other site 1009846003257 ABC transporter signature motif; other site 1009846003258 Walker B; other site 1009846003259 D-loop; other site 1009846003260 H-loop/switch region; other site 1009846003261 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1009846003262 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1009846003263 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1009846003264 active site 1009846003265 homotetramer interface [polypeptide binding]; other site 1009846003266 Predicted ATPase [General function prediction only]; Region: COG3911 1009846003267 AAA domain; Region: AAA_28; pfam13521 1009846003268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846003269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846003270 putative substrate translocation pore; other site 1009846003271 ecotin; Provisional; Region: PRK03719 1009846003272 secondary substrate binding site; other site 1009846003273 primary substrate binding site; other site 1009846003274 inhibition loop; other site 1009846003275 dimerization interface [polypeptide binding]; other site 1009846003276 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1009846003277 Rubredoxin; Region: Rubredoxin; pfam00301 1009846003278 iron binding site [ion binding]; other site 1009846003279 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1009846003280 ABC transporter ATPase component; Reviewed; Region: PRK11147 1009846003281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1009846003282 Walker A/P-loop; other site 1009846003283 ATP binding site [chemical binding]; other site 1009846003284 Q-loop/lid; other site 1009846003285 ABC transporter signature motif; other site 1009846003286 Walker B; other site 1009846003287 D-loop; other site 1009846003288 H-loop/switch region; other site 1009846003289 ABC transporter; Region: ABC_tran_2; pfam12848 1009846003290 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846003291 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1009846003292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003293 ATP binding site [chemical binding]; other site 1009846003294 Mg2+ binding site [ion binding]; other site 1009846003295 G-X-G motif; other site 1009846003296 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1009846003297 anchoring element; other site 1009846003298 dimer interface [polypeptide binding]; other site 1009846003299 ATP binding site [chemical binding]; other site 1009846003300 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1009846003301 active site 1009846003302 metal binding site [ion binding]; metal-binding site 1009846003303 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1009846003304 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1009846003305 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1009846003306 CAP-like domain; other site 1009846003307 active site 1009846003308 primary dimer interface [polypeptide binding]; other site 1009846003309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846003310 Predicted integral membrane protein [Function unknown]; Region: COG5615 1009846003311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846003312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846003313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846003314 dimerization interface [polypeptide binding]; other site 1009846003315 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846003316 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846003317 Chromate transporter; Region: Chromate_transp; pfam02417 1009846003318 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1009846003319 Chromate transporter; Region: Chromate_transp; pfam02417 1009846003320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846003321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846003322 metal binding site [ion binding]; metal-binding site 1009846003323 active site 1009846003324 I-site; other site 1009846003325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846003326 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1009846003327 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1009846003328 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1009846003329 homotrimer interaction site [polypeptide binding]; other site 1009846003330 putative active site [active] 1009846003331 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1009846003332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846003333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003334 homodimer interface [polypeptide binding]; other site 1009846003335 catalytic residue [active] 1009846003336 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846003337 EamA-like transporter family; Region: EamA; pfam00892 1009846003338 EamA-like transporter family; Region: EamA; pfam00892 1009846003339 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1009846003340 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846003341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846003342 DNA-binding site [nucleotide binding]; DNA binding site 1009846003343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846003344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003345 homodimer interface [polypeptide binding]; other site 1009846003346 catalytic residue [active] 1009846003347 heat shock protein 90; Provisional; Region: PRK05218 1009846003348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003349 ATP binding site [chemical binding]; other site 1009846003350 Mg2+ binding site [ion binding]; other site 1009846003351 G-X-G motif; other site 1009846003352 Chorismate lyase; Region: Chor_lyase; cl01230 1009846003353 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1009846003354 putative active site [active] 1009846003355 Helix-turn-helix domain; Region: HTH_37; pfam13744 1009846003356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1009846003357 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1009846003358 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1009846003359 Na binding site [ion binding]; other site 1009846003360 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1009846003361 dimer interface [polypeptide binding]; other site 1009846003362 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846003363 transaldolase-like protein; Provisional; Region: PTZ00411 1009846003364 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1009846003365 active site 1009846003366 dimer interface [polypeptide binding]; other site 1009846003367 catalytic residue [active] 1009846003368 Benzoate membrane transport protein; Region: BenE; pfam03594 1009846003369 benzoate transporter; Region: benE; TIGR00843 1009846003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1009846003371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1009846003372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846003373 Walker A motif; other site 1009846003374 ATP binding site [chemical binding]; other site 1009846003375 Walker B motif; other site 1009846003376 arginine finger; other site 1009846003377 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1009846003378 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1009846003379 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1009846003380 EamA-like transporter family; Region: EamA; pfam00892 1009846003381 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846003382 EamA-like transporter family; Region: EamA; pfam00892 1009846003383 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1009846003384 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1009846003385 minor groove reading motif; other site 1009846003386 helix-hairpin-helix signature motif; other site 1009846003387 substrate binding pocket [chemical binding]; other site 1009846003388 active site 1009846003389 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1009846003390 ferredoxin; Provisional; Region: PRK06991 1009846003391 Putative Fe-S cluster; Region: FeS; pfam04060 1009846003392 4Fe-4S binding domain; Region: Fer4; pfam00037 1009846003393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846003394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846003395 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1009846003396 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1009846003397 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1009846003398 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1009846003399 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1009846003400 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1009846003401 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1009846003402 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1009846003403 META domain; Region: META; pfam03724 1009846003404 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1009846003405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846003406 ATP-grasp domain; Region: ATP-grasp; pfam02222 1009846003407 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1009846003408 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1009846003409 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1009846003410 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1009846003411 ATP binding site [chemical binding]; other site 1009846003412 Mg++ binding site [ion binding]; other site 1009846003413 motif III; other site 1009846003414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846003415 nucleotide binding region [chemical binding]; other site 1009846003416 ATP-binding site [chemical binding]; other site 1009846003417 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1009846003418 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 1009846003419 active site 1009846003420 HIGH motif; other site 1009846003421 nucleotide binding site [chemical binding]; other site 1009846003422 active site 1009846003423 KMSKS motif; other site 1009846003424 rhodanese superfamily protein; Provisional; Region: PRK05320 1009846003425 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1009846003426 active site residue [active] 1009846003427 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1009846003428 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1009846003429 putative active site [active] 1009846003430 putative PHP Thumb interface [polypeptide binding]; other site 1009846003431 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1009846003432 generic binding surface II; other site 1009846003433 generic binding surface I; other site 1009846003434 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1009846003435 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846003436 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846003437 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1009846003438 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1009846003439 putative active site [active] 1009846003440 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1009846003441 O-Antigen ligase; Region: Wzy_C; pfam04932 1009846003442 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1009846003443 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1009846003444 active site 1009846003445 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1009846003446 putative metal binding site; other site 1009846003447 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1009846003448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846003449 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1009846003450 Walker A/P-loop; other site 1009846003451 ATP binding site [chemical binding]; other site 1009846003452 Q-loop/lid; other site 1009846003453 ABC transporter signature motif; other site 1009846003454 Walker B; other site 1009846003455 D-loop; other site 1009846003456 H-loop/switch region; other site 1009846003457 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1009846003458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846003459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846003460 putative substrate translocation pore; other site 1009846003461 PRC-barrel domain; Region: PRC; pfam05239 1009846003462 Protein with unknown function (DUF469); Region: DUF469; pfam04320 1009846003463 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1009846003464 ribonuclease G; Provisional; Region: PRK11712 1009846003465 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1009846003466 homodimer interface [polypeptide binding]; other site 1009846003467 oligonucleotide binding site [chemical binding]; other site 1009846003468 Maf-like protein; Region: Maf; pfam02545 1009846003469 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1009846003470 active site 1009846003471 dimer interface [polypeptide binding]; other site 1009846003472 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1009846003473 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1009846003474 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1009846003475 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1009846003476 active site 1009846003477 (T/H)XGH motif; other site 1009846003478 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1009846003479 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1009846003480 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1009846003481 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1009846003482 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1009846003483 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1009846003484 hypothetical protein; Validated; Region: PRK00110 1009846003485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846003486 active site 1009846003487 short chain dehydrogenase; Provisional; Region: PRK08339 1009846003488 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1009846003489 putative NAD(P) binding site [chemical binding]; other site 1009846003490 putative active site [active] 1009846003491 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 1009846003492 substrate binding site [chemical binding]; other site 1009846003493 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1009846003494 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1009846003495 NADP binding site [chemical binding]; other site 1009846003496 dimer interface [polypeptide binding]; other site 1009846003497 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1009846003498 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1009846003499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009846003500 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1009846003501 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1009846003502 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1009846003503 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1009846003504 Ligand Binding Site [chemical binding]; other site 1009846003505 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1009846003506 GAF domain; Region: GAF_3; pfam13492 1009846003507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846003508 dimer interface [polypeptide binding]; other site 1009846003509 phosphorylation site [posttranslational modification] 1009846003510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003511 ATP binding site [chemical binding]; other site 1009846003512 Mg2+ binding site [ion binding]; other site 1009846003513 G-X-G motif; other site 1009846003514 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1009846003515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846003516 active site 1009846003517 phosphorylation site [posttranslational modification] 1009846003518 intermolecular recognition site; other site 1009846003519 dimerization interface [polypeptide binding]; other site 1009846003520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846003521 DNA binding site [nucleotide binding] 1009846003522 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1009846003523 multidrug efflux system protein; Provisional; Region: PRK11431 1009846003524 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1009846003525 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1009846003526 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1009846003527 apolar tunnel; other site 1009846003528 heme binding site [chemical binding]; other site 1009846003529 dimerization interface [polypeptide binding]; other site 1009846003530 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1009846003531 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1009846003532 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1009846003533 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1009846003534 glucose-1-dehydrogenase; Provisional; Region: PRK06947 1009846003535 classical (c) SDRs; Region: SDR_c; cd05233 1009846003536 NAD(P) binding site [chemical binding]; other site 1009846003537 active site 1009846003538 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1009846003539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846003540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846003541 Bacterial transcriptional repressor; Region: TetR; pfam13972 1009846003542 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1009846003543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846003544 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1009846003545 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1009846003546 putative active site [active] 1009846003547 putative metal binding site [ion binding]; other site 1009846003548 RDD family; Region: RDD; pfam06271 1009846003549 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1009846003550 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 1009846003551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846003552 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1009846003553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846003554 DNA binding residues [nucleotide binding] 1009846003555 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 1009846003556 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846003557 PYR/PP interface [polypeptide binding]; other site 1009846003558 dimer interface [polypeptide binding]; other site 1009846003559 TPP binding site [chemical binding]; other site 1009846003560 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846003561 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1009846003562 TPP-binding site [chemical binding]; other site 1009846003563 dimer interface [polypeptide binding]; other site 1009846003564 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1009846003565 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1009846003566 putative valine binding site [chemical binding]; other site 1009846003567 dimer interface [polypeptide binding]; other site 1009846003568 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1009846003569 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1009846003570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1009846003571 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1009846003572 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1009846003573 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1009846003574 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1009846003575 2-isopropylmalate synthase; Validated; Region: PRK00915 1009846003576 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1009846003577 active site 1009846003578 catalytic residues [active] 1009846003579 metal binding site [ion binding]; metal-binding site 1009846003580 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1009846003581 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1009846003582 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1009846003583 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1009846003584 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1009846003585 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1009846003586 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1009846003587 active site clefts [active] 1009846003588 zinc binding site [ion binding]; other site 1009846003589 dimer interface [polypeptide binding]; other site 1009846003590 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1009846003591 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 1009846003592 putative ligand binding site [chemical binding]; other site 1009846003593 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1009846003594 16S/18S rRNA binding site [nucleotide binding]; other site 1009846003595 S13e-L30e interaction site [polypeptide binding]; other site 1009846003596 25S rRNA binding site [nucleotide binding]; other site 1009846003597 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1009846003598 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1009846003599 RNase E interface [polypeptide binding]; other site 1009846003600 trimer interface [polypeptide binding]; other site 1009846003601 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1009846003602 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1009846003603 RNase E interface [polypeptide binding]; other site 1009846003604 trimer interface [polypeptide binding]; other site 1009846003605 active site 1009846003606 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1009846003607 putative nucleic acid binding region [nucleotide binding]; other site 1009846003608 G-X-X-G motif; other site 1009846003609 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1009846003610 RNA binding site [nucleotide binding]; other site 1009846003611 domain interface; other site 1009846003612 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1009846003613 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1009846003614 NAD(P) binding site [chemical binding]; other site 1009846003615 triosephosphate isomerase; Provisional; Region: PRK14567 1009846003616 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1009846003617 substrate binding site [chemical binding]; other site 1009846003618 dimer interface [polypeptide binding]; other site 1009846003619 catalytic triad [active] 1009846003620 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1009846003621 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1009846003622 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1009846003623 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1009846003624 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1009846003625 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1009846003626 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1009846003627 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1009846003628 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1009846003629 putative dimer interface [polypeptide binding]; other site 1009846003630 [2Fe-2S] cluster binding site [ion binding]; other site 1009846003631 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1009846003632 SLBB domain; Region: SLBB; pfam10531 1009846003633 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1009846003634 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1009846003635 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846003636 catalytic loop [active] 1009846003637 iron binding site [ion binding]; other site 1009846003638 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1009846003639 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 1009846003640 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1009846003641 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1009846003642 4Fe-4S binding domain; Region: Fer4; cl02805 1009846003643 4Fe-4S binding domain; Region: Fer4; pfam00037 1009846003644 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1009846003645 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1009846003646 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1009846003647 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1009846003648 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1009846003649 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1009846003650 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1009846003651 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1009846003652 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1009846003653 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1009846003654 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 1009846003655 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1009846003656 dimer interface [polypeptide binding]; other site 1009846003657 ADP-ribose binding site [chemical binding]; other site 1009846003658 active site 1009846003659 nudix motif; other site 1009846003660 metal binding site [ion binding]; metal-binding site 1009846003661 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1009846003662 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1009846003663 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1009846003664 FAD binding site [chemical binding]; other site 1009846003665 substrate binding site [chemical binding]; other site 1009846003666 catalytic base [active] 1009846003667 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1009846003668 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1009846003669 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1009846003670 active site 1009846003671 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1009846003672 putative active site [active] 1009846003673 putative catalytic site [active] 1009846003674 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1009846003675 putative active site [active] 1009846003676 putative catalytic site [active] 1009846003677 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1009846003678 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1009846003679 C-terminal domain interface [polypeptide binding]; other site 1009846003680 GSH binding site (G-site) [chemical binding]; other site 1009846003681 dimer interface [polypeptide binding]; other site 1009846003682 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1009846003683 N-terminal domain interface [polypeptide binding]; other site 1009846003684 putative dimer interface [polypeptide binding]; other site 1009846003685 active site 1009846003686 enoyl-CoA hydratase; Provisional; Region: PRK07511 1009846003687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846003688 substrate binding site [chemical binding]; other site 1009846003689 oxyanion hole (OAH) forming residues; other site 1009846003690 trimer interface [polypeptide binding]; other site 1009846003691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846003692 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1009846003693 C-terminal domain interface [polypeptide binding]; other site 1009846003694 GSH binding site (G-site) [chemical binding]; other site 1009846003695 dimer interface [polypeptide binding]; other site 1009846003696 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 1009846003697 putative N-terminal domain interface [polypeptide binding]; other site 1009846003698 putative dimer interface [polypeptide binding]; other site 1009846003699 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846003700 methionine aminotransferase; Validated; Region: PRK09082 1009846003701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846003702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003703 homodimer interface [polypeptide binding]; other site 1009846003704 catalytic residue [active] 1009846003705 PIN domain; Region: PIN_3; pfam13470 1009846003706 hypothetical protein; Validated; Region: PRK02101 1009846003707 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1009846003708 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 1009846003709 putative active site [active] 1009846003710 Zn binding site [ion binding]; other site 1009846003711 Predicted membrane protein [Function unknown]; Region: COG3235 1009846003712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846003713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846003714 DNA binding residues [nucleotide binding] 1009846003715 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 1009846003716 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1009846003717 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1009846003718 DNA binding residues [nucleotide binding] 1009846003719 dimer interface [polypeptide binding]; other site 1009846003720 copper binding site [ion binding]; other site 1009846003721 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 1009846003722 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1009846003723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846003724 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1009846003725 active site 1009846003726 catalytic tetrad [active] 1009846003727 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 1009846003728 classical (c) SDRs; Region: SDR_c; cd05233 1009846003729 NAD(P) binding site [chemical binding]; other site 1009846003730 active site 1009846003731 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1009846003732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846003733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003734 homodimer interface [polypeptide binding]; other site 1009846003735 catalytic residue [active] 1009846003736 excinuclease ABC subunit B; Provisional; Region: PRK05298 1009846003737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846003738 ATP binding site [chemical binding]; other site 1009846003739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846003740 nucleotide binding region [chemical binding]; other site 1009846003741 ATP-binding site [chemical binding]; other site 1009846003742 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1009846003743 UvrB/uvrC motif; Region: UVR; pfam02151 1009846003744 Fe2+ transport protein; Region: Iron_transport; pfam10634 1009846003745 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1009846003746 Iron permease FTR1 family; Region: FTR1; cl00475 1009846003747 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1009846003748 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1009846003749 Hemin uptake protein hemP; Region: hemP; pfam10636 1009846003750 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 1009846003751 putative hydrophobic ligand binding site [chemical binding]; other site 1009846003752 Pirin-related protein [General function prediction only]; Region: COG1741 1009846003753 Pirin; Region: Pirin; pfam02678 1009846003754 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1009846003755 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846003756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846003757 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1009846003758 putative effector binding pocket; other site 1009846003759 putative dimerization interface [polypeptide binding]; other site 1009846003760 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1009846003761 TolR protein; Region: tolR; TIGR02801 1009846003762 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1009846003763 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1009846003764 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1009846003765 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1009846003766 glutamate racemase; Provisional; Region: PRK00865 1009846003767 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1009846003768 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1009846003769 heme binding site [chemical binding]; other site 1009846003770 ferroxidase pore; other site 1009846003771 ferroxidase diiron center [ion binding]; other site 1009846003772 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1009846003773 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1009846003774 hypothetical protein; Provisional; Region: PRK05208 1009846003775 EamA-like transporter family; Region: EamA; pfam00892 1009846003776 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846003777 EamA-like transporter family; Region: EamA; pfam00892 1009846003778 acetyl-CoA synthetase; Provisional; Region: PRK00174 1009846003779 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1009846003780 active site 1009846003781 CoA binding site [chemical binding]; other site 1009846003782 acyl-activating enzyme (AAE) consensus motif; other site 1009846003783 AMP binding site [chemical binding]; other site 1009846003784 acetate binding site [chemical binding]; other site 1009846003785 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 1009846003786 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1009846003787 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 1009846003788 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846003789 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1009846003790 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1009846003791 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846003792 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846003793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846003794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846003795 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1009846003796 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846003797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846003798 putative substrate translocation pore; other site 1009846003799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846003800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846003801 DNA binding residues [nucleotide binding] 1009846003802 dimerization interface [polypeptide binding]; other site 1009846003803 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1009846003804 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1009846003805 CysD dimerization site [polypeptide binding]; other site 1009846003806 G1 box; other site 1009846003807 putative GEF interaction site [polypeptide binding]; other site 1009846003808 GTP/Mg2+ binding site [chemical binding]; other site 1009846003809 Switch I region; other site 1009846003810 G2 box; other site 1009846003811 G3 box; other site 1009846003812 Switch II region; other site 1009846003813 G4 box; other site 1009846003814 G5 box; other site 1009846003815 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1009846003816 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1009846003817 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1009846003818 ligand-binding site [chemical binding]; other site 1009846003819 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1009846003820 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1009846003821 Active Sites [active] 1009846003822 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1009846003823 short chain dehydrogenase; Provisional; Region: PRK07890 1009846003824 classical (c) SDRs; Region: SDR_c; cd05233 1009846003825 NAD(P) binding site [chemical binding]; other site 1009846003826 active site 1009846003827 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1009846003828 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1009846003829 SnoaL-like domain; Region: SnoaL_3; pfam13474 1009846003830 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1009846003831 putative hydrophobic ligand binding site [chemical binding]; other site 1009846003832 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1009846003833 DNA photolyase; Region: DNA_photolyase; pfam00875 1009846003834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846003835 putative substrate translocation pore; other site 1009846003836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846003837 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846003838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846003839 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846003840 dimerization interface [polypeptide binding]; other site 1009846003841 substrate binding pocket [chemical binding]; other site 1009846003842 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1009846003843 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1009846003844 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1009846003845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846003846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846003847 substrate binding pocket [chemical binding]; other site 1009846003848 membrane-bound complex binding site; other site 1009846003849 hinge residues; other site 1009846003850 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1009846003851 active sites [active] 1009846003852 tetramer interface [polypeptide binding]; other site 1009846003853 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1009846003854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846003855 DNA-binding site [nucleotide binding]; DNA binding site 1009846003856 UTRA domain; Region: UTRA; pfam07702 1009846003857 urocanate hydratase; Provisional; Region: PRK05414 1009846003858 HutD; Region: HutD; pfam05962 1009846003859 imidazolonepropionase; Validated; Region: PRK09356 1009846003860 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1009846003861 active site 1009846003862 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1009846003863 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1009846003864 active site 1009846003865 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1009846003866 Peptidase C26; Region: Peptidase_C26; pfam07722 1009846003867 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1009846003868 catalytic triad [active] 1009846003869 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1009846003870 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009846003871 putative aminotransferase; Validated; Region: PRK07480 1009846003872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846003873 inhibitor-cofactor binding pocket; inhibition site 1009846003874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003875 catalytic residue [active] 1009846003876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1009846003877 Helix-turn-helix domain; Region: HTH_28; pfam13518 1009846003878 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846003879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846003880 glutamate racemase; Provisional; Region: PRK00865 1009846003881 aspartate racemase; Region: asp_race; TIGR00035 1009846003882 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1009846003883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846003884 putative DNA binding site [nucleotide binding]; other site 1009846003885 putative Zn2+ binding site [ion binding]; other site 1009846003886 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846003887 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1009846003888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846003890 homodimer interface [polypeptide binding]; other site 1009846003891 catalytic residue [active] 1009846003892 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1009846003893 homotrimer interaction site [polypeptide binding]; other site 1009846003894 putative active site [active] 1009846003895 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846003896 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846003897 trimer interface [polypeptide binding]; other site 1009846003898 eyelet of channel; other site 1009846003899 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009846003900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846003901 oxidative damage protection protein; Provisional; Region: PRK05408 1009846003902 N-acetylglutamate synthase; Validated; Region: PRK05279 1009846003903 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1009846003904 putative feedback inhibition sensing region; other site 1009846003905 putative nucleotide binding site [chemical binding]; other site 1009846003906 putative substrate binding site [chemical binding]; other site 1009846003907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846003908 Coenzyme A binding pocket [chemical binding]; other site 1009846003909 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1009846003910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846003911 ATP binding site [chemical binding]; other site 1009846003912 putative Mg++ binding site [ion binding]; other site 1009846003913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846003914 nucleotide binding region [chemical binding]; other site 1009846003915 ATP-binding site [chemical binding]; other site 1009846003916 Helicase associated domain (HA2); Region: HA2; pfam04408 1009846003917 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1009846003918 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1009846003919 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1009846003920 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1009846003921 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1009846003922 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1009846003923 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1009846003924 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1009846003925 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1009846003926 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1009846003927 putative MPT binding site; other site 1009846003928 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1009846003929 active site residue [active] 1009846003930 glutamine synthetase; Provisional; Region: glnA; PRK09469 1009846003931 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1009846003932 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009846003933 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1009846003934 PAS domain; Region: PAS; smart00091 1009846003935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846003936 dimer interface [polypeptide binding]; other site 1009846003937 phosphorylation site [posttranslational modification] 1009846003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003939 ATP binding site [chemical binding]; other site 1009846003940 Mg2+ binding site [ion binding]; other site 1009846003941 G-X-G motif; other site 1009846003942 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1009846003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846003944 active site 1009846003945 phosphorylation site [posttranslational modification] 1009846003946 intermolecular recognition site; other site 1009846003947 dimerization interface [polypeptide binding]; other site 1009846003948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846003949 Walker A motif; other site 1009846003950 ATP binding site [chemical binding]; other site 1009846003951 Walker B motif; other site 1009846003952 arginine finger; other site 1009846003953 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846003954 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1009846003955 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009846003956 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1009846003957 putative catalytic site [active] 1009846003958 putative phosphate binding site [ion binding]; other site 1009846003959 active site 1009846003960 metal binding site A [ion binding]; metal-binding site 1009846003961 DNA binding site [nucleotide binding] 1009846003962 putative AP binding site [nucleotide binding]; other site 1009846003963 putative metal binding site B [ion binding]; other site 1009846003964 aspartate racemase; Region: asp_race; TIGR00035 1009846003965 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1009846003966 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1009846003967 active site 1009846003968 DNA polymerase IV; Validated; Region: PRK02406 1009846003969 DNA binding site [nucleotide binding] 1009846003970 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1009846003971 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1009846003972 active site 1009846003973 Zn binding site [ion binding]; other site 1009846003974 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 1009846003975 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1009846003976 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1009846003977 homodimer interface [polypeptide binding]; other site 1009846003978 NADP binding site [chemical binding]; other site 1009846003979 substrate binding site [chemical binding]; other site 1009846003980 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1009846003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846003982 active site 1009846003983 phosphorylation site [posttranslational modification] 1009846003984 intermolecular recognition site; other site 1009846003985 dimerization interface [polypeptide binding]; other site 1009846003986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846003987 DNA binding residues [nucleotide binding] 1009846003988 dimerization interface [polypeptide binding]; other site 1009846003989 PAS domain S-box; Region: sensory_box; TIGR00229 1009846003990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846003991 putative active site [active] 1009846003992 heme pocket [chemical binding]; other site 1009846003993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846003994 dimer interface [polypeptide binding]; other site 1009846003995 phosphorylation site [posttranslational modification] 1009846003996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846003997 ATP binding site [chemical binding]; other site 1009846003998 Mg2+ binding site [ion binding]; other site 1009846003999 G-X-G motif; other site 1009846004000 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1009846004001 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1009846004002 dimer interface [polypeptide binding]; other site 1009846004003 TPP-binding site [chemical binding]; other site 1009846004004 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1009846004005 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1009846004006 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846004007 E3 interaction surface; other site 1009846004008 lipoyl attachment site [posttranslational modification]; other site 1009846004009 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846004010 E3 interaction surface; other site 1009846004011 lipoyl attachment site [posttranslational modification]; other site 1009846004012 e3 binding domain; Region: E3_binding; pfam02817 1009846004013 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1009846004014 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846004015 E3 interaction surface; other site 1009846004016 lipoyl attachment site [posttranslational modification]; other site 1009846004017 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1009846004018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846004019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846004020 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009846004021 Phasin protein; Region: Phasin_2; pfam09361 1009846004022 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1009846004023 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1009846004024 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846004025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846004026 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846004027 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1009846004028 Cysteine-rich domain; Region: CCG; pfam02754 1009846004029 Cysteine-rich domain; Region: CCG; pfam02754 1009846004030 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1009846004031 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1009846004032 4Fe-4S binding domain; Region: Fer4; pfam00037 1009846004033 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1009846004034 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1009846004035 Predicted transcriptional regulator [Transcription]; Region: COG1959 1009846004036 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1009846004037 cysteine desulfurase; Provisional; Region: PRK14012 1009846004038 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1009846004039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846004040 catalytic residue [active] 1009846004041 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1009846004042 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1009846004043 trimerization site [polypeptide binding]; other site 1009846004044 active site 1009846004045 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1009846004046 co-chaperone HscB; Provisional; Region: hscB; PRK03578 1009846004047 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1009846004048 HSP70 interaction site [polypeptide binding]; other site 1009846004049 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1009846004050 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1009846004051 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1009846004052 nucleotide binding site [chemical binding]; other site 1009846004053 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1009846004054 SBD interface [polypeptide binding]; other site 1009846004055 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1009846004056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846004057 catalytic loop [active] 1009846004058 iron binding site [ion binding]; other site 1009846004059 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1009846004060 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1009846004061 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1009846004062 dimer interface [polypeptide binding]; other site 1009846004063 putative anticodon binding site; other site 1009846004064 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1009846004065 motif 1; other site 1009846004066 active site 1009846004067 motif 2; other site 1009846004068 motif 3; other site 1009846004069 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1009846004070 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1009846004071 RF-1 domain; Region: RF-1; pfam00472 1009846004072 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1009846004073 DHH family; Region: DHH; pfam01368 1009846004074 DHHA1 domain; Region: DHHA1; pfam02272 1009846004075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 1009846004076 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1009846004077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009846004078 FtsX-like permease family; Region: FtsX; pfam02687 1009846004079 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1009846004080 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009846004081 Walker A/P-loop; other site 1009846004082 ATP binding site [chemical binding]; other site 1009846004083 Q-loop/lid; other site 1009846004084 ABC transporter signature motif; other site 1009846004085 Walker B; other site 1009846004086 D-loop; other site 1009846004087 H-loop/switch region; other site 1009846004088 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1009846004089 active site 1009846004090 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1009846004091 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1009846004092 Competence protein; Region: Competence; pfam03772 1009846004093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1009846004094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846004095 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846004096 CTP synthetase; Validated; Region: pyrG; PRK05380 1009846004097 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1009846004098 Catalytic site [active] 1009846004099 active site 1009846004100 UTP binding site [chemical binding]; other site 1009846004101 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1009846004102 active site 1009846004103 putative oxyanion hole; other site 1009846004104 catalytic triad [active] 1009846004105 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1009846004106 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1009846004107 enolase; Provisional; Region: eno; PRK00077 1009846004108 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1009846004109 dimer interface [polypeptide binding]; other site 1009846004110 metal binding site [ion binding]; metal-binding site 1009846004111 substrate binding pocket [chemical binding]; other site 1009846004112 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1009846004113 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1009846004114 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1009846004115 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1009846004116 dimerization interface [polypeptide binding]; other site 1009846004117 domain crossover interface; other site 1009846004118 redox-dependent activation switch; other site 1009846004119 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1009846004120 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1009846004121 trimer interface [polypeptide binding]; other site 1009846004122 putative metal binding site [ion binding]; other site 1009846004123 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1009846004124 dinuclear metal binding motif [ion binding]; other site 1009846004125 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846004126 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846004127 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846004128 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1009846004129 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1009846004130 active site 1009846004131 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1009846004132 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1009846004133 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1009846004134 Peptidase family M50; Region: Peptidase_M50; pfam02163 1009846004135 active site 1009846004136 putative substrate binding region [chemical binding]; other site 1009846004137 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1009846004138 active site 1009846004139 HIGH motif; other site 1009846004140 dimer interface [polypeptide binding]; other site 1009846004141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009846004142 active site 1009846004143 KMSKS motif; other site 1009846004144 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1009846004145 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1009846004146 dimer interface [polypeptide binding]; other site 1009846004147 active site 1009846004148 catalytic residue [active] 1009846004149 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1009846004150 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1009846004151 Cupin superfamily protein; Region: Cupin_4; pfam08007 1009846004152 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1009846004153 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1009846004154 MutS domain I; Region: MutS_I; pfam01624 1009846004155 MutS domain II; Region: MutS_II; pfam05188 1009846004156 MutS domain III; Region: MutS_III; pfam05192 1009846004157 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1009846004158 Walker A/P-loop; other site 1009846004159 ATP binding site [chemical binding]; other site 1009846004160 Q-loop/lid; other site 1009846004161 ABC transporter signature motif; other site 1009846004162 Walker B; other site 1009846004163 D-loop; other site 1009846004164 H-loop/switch region; other site 1009846004165 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1009846004166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846004167 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846004168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846004169 putative substrate translocation pore; other site 1009846004170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846004171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846004172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846004173 dimerization interface [polypeptide binding]; other site 1009846004174 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1009846004175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846004176 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1009846004177 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1009846004178 active site 1009846004179 dimerization interface [polypeptide binding]; other site 1009846004180 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1009846004181 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1009846004182 serine O-acetyltransferase; Region: cysE; TIGR01172 1009846004183 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1009846004184 trimer interface [polypeptide binding]; other site 1009846004185 active site 1009846004186 substrate binding site [chemical binding]; other site 1009846004187 CoA binding site [chemical binding]; other site 1009846004188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846004189 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1009846004190 putative active site [active] 1009846004191 putative metal binding site [ion binding]; other site 1009846004192 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1009846004193 substrate binding site [chemical binding]; other site 1009846004194 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1009846004195 substrate binding site [chemical binding]; other site 1009846004196 TPR repeat; Region: TPR_11; pfam13414 1009846004197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846004198 binding surface 1009846004199 TPR motif; other site 1009846004200 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1009846004201 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1009846004202 active site 1009846004203 HIGH motif; other site 1009846004204 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1009846004205 KMSKS motif; other site 1009846004206 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1009846004207 tRNA binding surface [nucleotide binding]; other site 1009846004208 anticodon binding site; other site 1009846004209 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1009846004210 endonuclease III; Region: ENDO3c; smart00478 1009846004211 minor groove reading motif; other site 1009846004212 helix-hairpin-helix signature motif; other site 1009846004213 substrate binding pocket [chemical binding]; other site 1009846004214 active site 1009846004215 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1009846004216 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1009846004217 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1009846004218 Ligand Binding Site [chemical binding]; other site 1009846004219 TilS substrate binding domain; Region: TilS; pfam09179 1009846004220 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1009846004221 aspartate kinase; Reviewed; Region: PRK06635 1009846004222 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1009846004223 putative Mg ion binding site [ion binding]; other site 1009846004224 putative aspartate binding site [chemical binding]; other site 1009846004225 putative catalytic residues [active] 1009846004226 putative nucleotide binding site [chemical binding]; other site 1009846004227 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1009846004228 putative allosteric regulatory site; other site 1009846004229 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1009846004230 galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288 1009846004231 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1009846004232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1009846004233 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1009846004234 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1009846004235 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1009846004236 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1009846004237 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1009846004238 D-pathway; other site 1009846004239 Putative ubiquinol binding site [chemical binding]; other site 1009846004240 Low-spin heme (heme b) binding site [chemical binding]; other site 1009846004241 Putative water exit pathway; other site 1009846004242 Binuclear center (heme o3/CuB) [ion binding]; other site 1009846004243 K-pathway; other site 1009846004244 Putative proton exit pathway; other site 1009846004245 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1009846004246 Subunit I/III interface [polypeptide binding]; other site 1009846004247 Subunit III/IV interface [polypeptide binding]; other site 1009846004248 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1009846004249 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846004250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846004251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846004252 active site 1009846004253 phosphorylation site [posttranslational modification] 1009846004254 intermolecular recognition site; other site 1009846004255 dimerization interface [polypeptide binding]; other site 1009846004256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846004257 DNA binding site [nucleotide binding] 1009846004258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846004259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846004260 dimerization interface [polypeptide binding]; other site 1009846004261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846004262 dimer interface [polypeptide binding]; other site 1009846004263 phosphorylation site [posttranslational modification] 1009846004264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846004265 ATP binding site [chemical binding]; other site 1009846004266 Mg2+ binding site [ion binding]; other site 1009846004267 G-X-G motif; other site 1009846004268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846004269 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1009846004270 DNA binding site [nucleotide binding] 1009846004271 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846004272 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846004273 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846004274 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846004275 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846004276 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1009846004277 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1009846004278 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1009846004279 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1009846004280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846004281 dimer interface [polypeptide binding]; other site 1009846004282 conserved gate region; other site 1009846004283 putative PBP binding loops; other site 1009846004284 ABC-ATPase subunit interface; other site 1009846004285 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1009846004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846004287 dimer interface [polypeptide binding]; other site 1009846004288 conserved gate region; other site 1009846004289 putative PBP binding loops; other site 1009846004290 ABC-ATPase subunit interface; other site 1009846004291 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1009846004292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846004293 Walker A/P-loop; other site 1009846004294 ATP binding site [chemical binding]; other site 1009846004295 Q-loop/lid; other site 1009846004296 ABC transporter signature motif; other site 1009846004297 Walker B; other site 1009846004298 D-loop; other site 1009846004299 H-loop/switch region; other site 1009846004300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846004301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846004302 Walker A/P-loop; other site 1009846004303 ATP binding site [chemical binding]; other site 1009846004304 Q-loop/lid; other site 1009846004305 ABC transporter signature motif; other site 1009846004306 Walker B; other site 1009846004307 D-loop; other site 1009846004308 H-loop/switch region; other site 1009846004309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846004310 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1009846004311 NlpC/P60 family; Region: NLPC_P60; pfam00877 1009846004312 hypothetical protein; Provisional; Region: PRK10279 1009846004313 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1009846004314 nucleophile elbow; other site 1009846004315 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1009846004316 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1009846004317 active site 1009846004318 HIGH motif; other site 1009846004319 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1009846004320 active site 1009846004321 KMSKS motif; other site 1009846004322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846004323 Coenzyme A binding pocket [chemical binding]; other site 1009846004324 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846004325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846004326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846004327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846004328 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1009846004329 putative active site pocket [active] 1009846004330 dimerization interface [polypeptide binding]; other site 1009846004331 putative catalytic residue [active] 1009846004332 malate synthase A; Region: malate_syn_A; TIGR01344 1009846004333 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1009846004334 active site 1009846004335 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1009846004336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846004337 motif II; other site 1009846004338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846004339 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846004340 putative effector binding pocket; other site 1009846004341 dimerization interface [polypeptide binding]; other site 1009846004342 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846004343 Ligand Binding Site [chemical binding]; other site 1009846004344 isocitrate lyase; Provisional; Region: PRK15063 1009846004345 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1009846004346 tetramer interface [polypeptide binding]; other site 1009846004347 active site 1009846004348 Mg2+/Mn2+ binding site [ion binding]; other site 1009846004349 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1009846004350 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1009846004351 ATP binding site [chemical binding]; other site 1009846004352 Mg++ binding site [ion binding]; other site 1009846004353 motif III; other site 1009846004354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846004355 nucleotide binding region [chemical binding]; other site 1009846004356 ATP-binding site [chemical binding]; other site 1009846004357 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 1009846004358 acyl-CoA binding pocket [chemical binding]; other site 1009846004359 CoA binding site [chemical binding]; other site 1009846004360 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1009846004361 Glycoprotease family; Region: Peptidase_M22; pfam00814 1009846004362 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1009846004363 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846004364 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1009846004365 Fe-S cluster binding site [ion binding]; other site 1009846004366 active site 1009846004367 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1009846004368 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1009846004369 dimer interface [polypeptide binding]; other site 1009846004370 substrate binding site [chemical binding]; other site 1009846004371 ATP binding site [chemical binding]; other site 1009846004372 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1009846004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846004374 alanine racemase; Reviewed; Region: dadX; PRK03646 1009846004375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1009846004376 active site 1009846004377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846004378 substrate binding site [chemical binding]; other site 1009846004379 catalytic residues [active] 1009846004380 dimer interface [polypeptide binding]; other site 1009846004381 DNA repair protein RadA; Provisional; Region: PRK11823 1009846004382 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1009846004383 Walker A motif/ATP binding site; other site 1009846004384 ATP binding site [chemical binding]; other site 1009846004385 Walker B motif; other site 1009846004386 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1009846004387 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 1009846004388 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1009846004389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846004390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846004391 ABC transporter; Region: ABC_tran_2; pfam12848 1009846004392 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846004393 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1009846004394 catalytic residues [active] 1009846004395 dimer interface [polypeptide binding]; other site 1009846004396 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1009846004397 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1009846004398 putative active site [active] 1009846004399 catalytic site [active] 1009846004400 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 1009846004401 putative active site [active] 1009846004402 catalytic site [active] 1009846004403 HemK family putative methylases; Region: hemK_fam; TIGR00536 1009846004404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846004405 S-adenosylmethionine binding site [chemical binding]; other site 1009846004406 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1009846004407 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1009846004408 metal binding site [ion binding]; metal-binding site 1009846004409 dimer interface [polypeptide binding]; other site 1009846004410 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1009846004411 ArsC family; Region: ArsC; pfam03960 1009846004412 putative catalytic residues [active] 1009846004413 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1009846004414 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1009846004415 trimer interface [polypeptide binding]; other site 1009846004416 active site 1009846004417 substrate binding site [chemical binding]; other site 1009846004418 CoA binding site [chemical binding]; other site 1009846004419 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1009846004420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846004421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846004422 homodimer interface [polypeptide binding]; other site 1009846004423 catalytic residue [active] 1009846004424 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846004425 EamA-like transporter family; Region: EamA; pfam00892 1009846004426 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1009846004427 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1009846004428 Walker A/P-loop; other site 1009846004429 ATP binding site [chemical binding]; other site 1009846004430 Q-loop/lid; other site 1009846004431 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1009846004432 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1009846004433 Q-loop/lid; other site 1009846004434 ABC transporter signature motif; other site 1009846004435 Walker B; other site 1009846004436 D-loop; other site 1009846004437 H-loop/switch region; other site 1009846004438 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 1009846004439 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1009846004440 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1009846004441 nucleotide binding pocket [chemical binding]; other site 1009846004442 K-X-D-G motif; other site 1009846004443 catalytic site [active] 1009846004444 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1009846004445 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1009846004446 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1009846004447 Dimer interface [polypeptide binding]; other site 1009846004448 BRCT sequence motif; other site 1009846004449 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1009846004450 active site 1009846004451 catalytic residues [active] 1009846004452 metal binding site [ion binding]; metal-binding site 1009846004453 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1009846004454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846004455 RNA binding surface [nucleotide binding]; other site 1009846004456 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1009846004457 active site 1009846004458 PII uridylyl-transferase; Provisional; Region: PRK03059 1009846004459 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1009846004460 metal binding triad; other site 1009846004461 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1009846004462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009846004463 Zn2+ binding site [ion binding]; other site 1009846004464 Mg2+ binding site [ion binding]; other site 1009846004465 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1009846004466 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1009846004467 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1009846004468 active site 1009846004469 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1009846004470 rRNA interaction site [nucleotide binding]; other site 1009846004471 S8 interaction site; other site 1009846004472 putative laminin-1 binding site; other site 1009846004473 elongation factor Ts; Provisional; Region: tsf; PRK09377 1009846004474 UBA/TS-N domain; Region: UBA; pfam00627 1009846004475 Elongation factor TS; Region: EF_TS; pfam00889 1009846004476 Elongation factor TS; Region: EF_TS; pfam00889 1009846004477 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1009846004478 putative nucleotide binding site [chemical binding]; other site 1009846004479 uridine monophosphate binding site [chemical binding]; other site 1009846004480 homohexameric interface [polypeptide binding]; other site 1009846004481 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1009846004482 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1009846004483 hinge region; other site 1009846004484 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1009846004485 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1009846004486 catalytic residue [active] 1009846004487 putative FPP diphosphate binding site; other site 1009846004488 putative FPP binding hydrophobic cleft; other site 1009846004489 dimer interface [polypeptide binding]; other site 1009846004490 putative IPP diphosphate binding site; other site 1009846004491 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1009846004492 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1009846004493 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1009846004494 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 1009846004495 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1009846004496 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1009846004497 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1009846004498 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1009846004499 active site 1009846004500 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1009846004501 protein binding site [polypeptide binding]; other site 1009846004502 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1009846004503 putative substrate binding region [chemical binding]; other site 1009846004504 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1009846004505 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846004506 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846004507 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846004508 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846004509 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846004510 Surface antigen; Region: Bac_surface_Ag; pfam01103 1009846004511 periplasmic chaperone; Provisional; Region: PRK10780 1009846004512 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1009846004513 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1009846004514 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1009846004515 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1009846004516 trimer interface [polypeptide binding]; other site 1009846004517 active site 1009846004518 UDP-GlcNAc binding site [chemical binding]; other site 1009846004519 lipid binding site [chemical binding]; lipid-binding site 1009846004520 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1009846004521 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1009846004522 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1009846004523 active site 1009846004524 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1009846004525 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1009846004526 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1009846004527 RNA/DNA hybrid binding site [nucleotide binding]; other site 1009846004528 active site 1009846004529 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1009846004530 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1009846004531 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1009846004532 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1009846004533 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1009846004534 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1009846004535 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1009846004536 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1009846004537 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1009846004538 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1009846004539 SmpB-tmRNA interface; other site 1009846004540 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1009846004541 putative coenzyme Q binding site [chemical binding]; other site 1009846004542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 1009846004543 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846004544 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1009846004545 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1009846004546 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1009846004547 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1009846004548 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1009846004549 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1009846004550 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1009846004551 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1009846004552 active site 1009846004553 GMP synthase; Reviewed; Region: guaA; PRK00074 1009846004554 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1009846004555 AMP/PPi binding site [chemical binding]; other site 1009846004556 candidate oxyanion hole; other site 1009846004557 catalytic triad [active] 1009846004558 potential glutamine specificity residues [chemical binding]; other site 1009846004559 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1009846004560 ATP Binding subdomain [chemical binding]; other site 1009846004561 Ligand Binding sites [chemical binding]; other site 1009846004562 Dimerization subdomain; other site 1009846004563 Putative amidotransferase; Region: DUF4066; pfam13278 1009846004564 conserved cys residue [active] 1009846004565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846004566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846004567 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1009846004568 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1009846004569 nucleoside/Zn binding site; other site 1009846004570 dimer interface [polypeptide binding]; other site 1009846004571 catalytic motif [active] 1009846004572 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1009846004573 dimer interface [polypeptide binding]; other site 1009846004574 catalytic triad [active] 1009846004575 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846004576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846004577 DNA-binding site [nucleotide binding]; DNA binding site 1009846004578 FCD domain; Region: FCD; pfam07729 1009846004579 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1009846004580 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1009846004581 Na binding site [ion binding]; other site 1009846004582 putative substrate binding site [chemical binding]; other site 1009846004583 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1009846004584 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1009846004585 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1009846004586 active site 1009846004587 catalytic site [active] 1009846004588 tetramer interface [polypeptide binding]; other site 1009846004589 OHCU decarboxylase; Region: UHCUDC; TIGR03164 1009846004590 allantoicase; Provisional; Region: PRK13257 1009846004591 Allantoicase repeat; Region: Allantoicase; pfam03561 1009846004592 Allantoicase repeat; Region: Allantoicase; pfam03561 1009846004593 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1009846004594 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1009846004595 ACT domain; Region: ACT_3; pfam10000 1009846004596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1009846004597 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1009846004598 Predicted membrane protein [Function unknown]; Region: COG3748 1009846004599 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1009846004600 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846004601 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1009846004602 active site 1009846004603 homotetramer interface [polypeptide binding]; other site 1009846004604 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1009846004605 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1009846004606 active site 1009846004607 putative substrate binding pocket [chemical binding]; other site 1009846004608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846004609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846004610 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 1009846004611 putative substrate binding pocket [chemical binding]; other site 1009846004612 putative dimerization interface [polypeptide binding]; other site 1009846004613 Dodecin; Region: Dodecin; pfam07311 1009846004614 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846004615 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1009846004616 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1009846004617 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1009846004618 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1009846004619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846004620 TPR motif; other site 1009846004621 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1009846004622 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1009846004623 Transglycosylase; Region: Transgly; pfam00912 1009846004624 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009846004625 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1009846004626 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1009846004627 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1009846004628 tetramer interface [polypeptide binding]; other site 1009846004629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846004630 catalytic residue [active] 1009846004631 acetylornithine deacetylase; Provisional; Region: PRK07522 1009846004632 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1009846004633 metal binding site [ion binding]; metal-binding site 1009846004634 putative dimer interface [polypeptide binding]; other site 1009846004635 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1009846004636 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1009846004637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846004638 ATP binding site [chemical binding]; other site 1009846004639 putative Mg++ binding site [ion binding]; other site 1009846004640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846004641 nucleotide binding region [chemical binding]; other site 1009846004642 ATP-binding site [chemical binding]; other site 1009846004643 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1009846004644 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1009846004645 substrate binding site; other site 1009846004646 dimer interface; other site 1009846004647 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1009846004648 homotrimer interaction site [polypeptide binding]; other site 1009846004649 zinc binding site [ion binding]; other site 1009846004650 CDP-binding sites; other site 1009846004651 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1009846004652 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846004653 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1009846004654 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1009846004655 dimer interface [polypeptide binding]; other site 1009846004656 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1009846004657 catalytic triad [active] 1009846004658 peroxidatic and resolving cysteines [active] 1009846004659 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1009846004660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846004661 dimer interface [polypeptide binding]; other site 1009846004662 phosphorylation site [posttranslational modification] 1009846004663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846004664 ATP binding site [chemical binding]; other site 1009846004665 Mg2+ binding site [ion binding]; other site 1009846004666 G-X-G motif; other site 1009846004667 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1009846004668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846004669 active site 1009846004670 phosphorylation site [posttranslational modification] 1009846004671 intermolecular recognition site; other site 1009846004672 dimerization interface [polypeptide binding]; other site 1009846004673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846004674 DNA binding site [nucleotide binding] 1009846004675 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1009846004676 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1009846004677 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 1009846004678 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1009846004679 active site lid residues [active] 1009846004680 substrate binding pocket [chemical binding]; other site 1009846004681 catalytic residues [active] 1009846004682 substrate-Mg2+ binding site; other site 1009846004683 aspartate-rich region 1; other site 1009846004684 aspartate-rich region 2; other site 1009846004685 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1009846004686 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1009846004687 active site 1009846004688 Zn binding site [ion binding]; other site 1009846004689 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846004690 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846004691 trimer interface [polypeptide binding]; other site 1009846004692 eyelet of channel; other site 1009846004693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846004694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846004695 dimerization interface [polypeptide binding]; other site 1009846004696 DNA binding residues [nucleotide binding] 1009846004697 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1009846004698 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009846004699 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009846004700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846004701 MarR family; Region: MarR_2; pfam12802 1009846004702 MarR family; Region: MarR_2; cl17246 1009846004703 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1009846004704 trigger factor; Provisional; Region: tig; PRK01490 1009846004705 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009846004706 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1009846004707 Clp protease; Region: CLP_protease; pfam00574 1009846004708 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1009846004709 oligomer interface [polypeptide binding]; other site 1009846004710 active site residues [active] 1009846004711 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1009846004712 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1009846004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846004714 Walker A motif; other site 1009846004715 ATP binding site [chemical binding]; other site 1009846004716 Walker B motif; other site 1009846004717 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1009846004718 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1009846004719 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1009846004720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846004721 Walker A motif; other site 1009846004722 ATP binding site [chemical binding]; other site 1009846004723 Walker B motif; other site 1009846004724 arginine finger; other site 1009846004725 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1009846004726 SurA N-terminal domain; Region: SurA_N_3; cl07813 1009846004727 periplasmic folding chaperone; Provisional; Region: PRK10788 1009846004728 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1009846004729 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1009846004730 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1009846004731 active site 1009846004732 catalytic triad [active] 1009846004733 oxyanion hole [active] 1009846004734 switch loop; other site 1009846004735 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1009846004736 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009846004737 Walker A/P-loop; other site 1009846004738 ATP binding site [chemical binding]; other site 1009846004739 Q-loop/lid; other site 1009846004740 ABC transporter signature motif; other site 1009846004741 Walker B; other site 1009846004742 D-loop; other site 1009846004743 H-loop/switch region; other site 1009846004744 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1009846004745 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1009846004746 active site 1009846004747 dimer interface [polypeptide binding]; other site 1009846004748 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1009846004749 dimer interface [polypeptide binding]; other site 1009846004750 active site 1009846004751 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1009846004752 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1009846004753 putative substrate binding site [chemical binding]; other site 1009846004754 putative ATP binding site [chemical binding]; other site 1009846004755 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1009846004756 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1009846004757 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1009846004758 dimerization interface [polypeptide binding]; other site 1009846004759 ATP binding site [chemical binding]; other site 1009846004760 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1009846004761 dimerization interface [polypeptide binding]; other site 1009846004762 ATP binding site [chemical binding]; other site 1009846004763 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1009846004764 putative active site [active] 1009846004765 catalytic triad [active] 1009846004766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846004767 Coenzyme A binding pocket [chemical binding]; other site 1009846004768 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1009846004769 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1009846004770 BolA-like protein; Region: BolA; pfam01722 1009846004771 intracellular septation protein A; Reviewed; Region: PRK00259 1009846004772 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1009846004773 SelR domain; Region: SelR; pfam01641 1009846004774 hypothetical protein; Validated; Region: PRK00029 1009846004775 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1009846004776 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1009846004777 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1009846004778 dimer interface [polypeptide binding]; other site 1009846004779 acyl-activating enzyme (AAE) consensus motif; other site 1009846004780 putative active site [active] 1009846004781 AMP binding site [chemical binding]; other site 1009846004782 putative CoA binding site [chemical binding]; other site 1009846004783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846004784 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1009846004785 substrate binding site [chemical binding]; other site 1009846004786 oxyanion hole (OAH) forming residues; other site 1009846004787 trimer interface [polypeptide binding]; other site 1009846004788 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846004789 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846004790 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846004791 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1009846004792 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846004793 catalytic triad [active] 1009846004794 metal binding site [ion binding]; metal-binding site 1009846004795 conserved cis-peptide bond; other site 1009846004796 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1009846004797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846004798 dimer interface [polypeptide binding]; other site 1009846004799 active site 1009846004800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846004801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846004802 metal binding site [ion binding]; metal-binding site 1009846004803 active site 1009846004804 I-site; other site 1009846004805 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1009846004806 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1009846004807 CoenzymeA binding site [chemical binding]; other site 1009846004808 subunit interaction site [polypeptide binding]; other site 1009846004809 PHB binding site; other site 1009846004810 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1009846004811 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846004812 substrate binding pocket [chemical binding]; other site 1009846004813 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1009846004814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846004815 Coenzyme A binding pocket [chemical binding]; other site 1009846004816 NRDE protein; Region: NRDE; cl01315 1009846004817 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1009846004818 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1009846004819 YceG-like family; Region: YceG; pfam02618 1009846004820 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1009846004821 dimerization interface [polypeptide binding]; other site 1009846004822 thymidylate kinase; Validated; Region: tmk; PRK00698 1009846004823 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1009846004824 TMP-binding site; other site 1009846004825 ATP-binding site [chemical binding]; other site 1009846004826 DNA polymerase III subunit delta'; Validated; Region: PRK06964 1009846004827 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1009846004828 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1009846004829 active site 1009846004830 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846004831 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1009846004832 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846004833 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846004834 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846004835 Predicted ATPase [General function prediction only]; Region: COG4637 1009846004836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846004837 Walker A/P-loop; other site 1009846004838 ATP binding site [chemical binding]; other site 1009846004839 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1009846004840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846004841 putative ADP-binding pocket [chemical binding]; other site 1009846004842 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1009846004843 Domain of unknown function DUF221; Region: DUF221; pfam02714 1009846004844 psiF repeat; Region: PsiF_repeat; pfam07769 1009846004845 psiF repeat; Region: PsiF_repeat; pfam07769 1009846004846 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1009846004847 active site 1009846004848 homodimer interface [polypeptide binding]; other site 1009846004849 homotetramer interface [polypeptide binding]; other site 1009846004850 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1009846004851 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846004852 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1009846004853 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846004854 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1009846004855 glyoxylate carboligase; Provisional; Region: PRK11269 1009846004856 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846004857 PYR/PP interface [polypeptide binding]; other site 1009846004858 dimer interface [polypeptide binding]; other site 1009846004859 TPP binding site [chemical binding]; other site 1009846004860 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846004861 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1009846004862 TPP-binding site [chemical binding]; other site 1009846004863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846004864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846004865 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846004866 putative effector binding pocket; other site 1009846004867 dimerization interface [polypeptide binding]; other site 1009846004868 RNA polymerase sigma factor; Provisional; Region: PRK12533 1009846004869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846004870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846004871 DNA binding residues [nucleotide binding] 1009846004872 Putative zinc-finger; Region: zf-HC2; pfam13490 1009846004873 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1009846004874 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1009846004875 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1009846004876 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1009846004877 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1009846004878 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1009846004879 replicative DNA helicase; Provisional; Region: PRK07004 1009846004880 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1009846004881 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1009846004882 Walker A motif; other site 1009846004883 ATP binding site [chemical binding]; other site 1009846004884 Walker B motif; other site 1009846004885 DNA binding loops [nucleotide binding] 1009846004886 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1009846004887 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1009846004888 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1009846004889 NlpC/P60 family; Region: NLPC_P60; pfam00877 1009846004890 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1009846004891 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1009846004892 putative active site [active] 1009846004893 PhoH-like protein; Region: PhoH; pfam02562 1009846004894 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1009846004895 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846004896 catalytic triad [active] 1009846004897 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1009846004898 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1009846004899 putative active site [active] 1009846004900 putative catalytic site [active] 1009846004901 putative Zn binding site [ion binding]; other site 1009846004902 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 1009846004903 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1009846004904 NAD binding site [chemical binding]; other site 1009846004905 substrate binding site [chemical binding]; other site 1009846004906 active site 1009846004907 putative formyltransferase; Provisional; Region: PRK06988 1009846004908 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1009846004909 active site 1009846004910 substrate binding site [chemical binding]; other site 1009846004911 cosubstrate binding site; other site 1009846004912 catalytic site [active] 1009846004913 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1009846004914 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1009846004915 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1009846004916 Ligand binding site; other site 1009846004917 Putative Catalytic site; other site 1009846004918 DXD motif; other site 1009846004919 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1009846004920 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1009846004921 inhibitor-cofactor binding pocket; inhibition site 1009846004922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846004923 catalytic residue [active] 1009846004924 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1009846004925 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1009846004926 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1009846004927 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 1009846004928 aminotransferase AlaT; Validated; Region: PRK09265 1009846004929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846004930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846004931 homodimer interface [polypeptide binding]; other site 1009846004932 catalytic residue [active] 1009846004933 homoserine dehydrogenase; Provisional; Region: PRK06349 1009846004934 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1009846004935 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1009846004936 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1009846004937 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1009846004938 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1009846004939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846004940 catalytic residue [active] 1009846004941 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1009846004942 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1009846004943 dimer interface [polypeptide binding]; other site 1009846004944 putative functional site; other site 1009846004945 putative MPT binding site; other site 1009846004946 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1009846004947 MoaE interaction surface [polypeptide binding]; other site 1009846004948 MoeB interaction surface [polypeptide binding]; other site 1009846004949 thiocarboxylated glycine; other site 1009846004950 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1009846004951 MoaE homodimer interface [polypeptide binding]; other site 1009846004952 MoaD interaction [polypeptide binding]; other site 1009846004953 active site residues [active] 1009846004954 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1009846004955 apolar tunnel; other site 1009846004956 heme binding site [chemical binding]; other site 1009846004957 dimerization interface [polypeptide binding]; other site 1009846004958 Transcriptional regulator; Region: Rrf2; cl17282 1009846004959 Rrf2 family protein; Region: rrf2_super; TIGR00738 1009846004960 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1009846004961 Clp amino terminal domain; Region: Clp_N; pfam02861 1009846004962 Clp amino terminal domain; Region: Clp_N; pfam02861 1009846004963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846004964 Walker A motif; other site 1009846004965 ATP binding site [chemical binding]; other site 1009846004966 Walker B motif; other site 1009846004967 arginine finger; other site 1009846004968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846004969 Walker A motif; other site 1009846004970 ATP binding site [chemical binding]; other site 1009846004971 Walker B motif; other site 1009846004972 arginine finger; other site 1009846004973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1009846004974 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1009846004975 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1009846004976 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1009846004977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009846004978 DNA binding residues [nucleotide binding] 1009846004979 putative dimer interface [polypeptide binding]; other site 1009846004980 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1009846004981 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1009846004982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846004983 Walker A motif; other site 1009846004984 ATP binding site [chemical binding]; other site 1009846004985 Walker B motif; other site 1009846004986 arginine finger; other site 1009846004987 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846004988 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1009846004989 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1009846004990 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1009846004991 tetramer interface [polypeptide binding]; other site 1009846004992 TPP-binding site [chemical binding]; other site 1009846004993 heterodimer interface [polypeptide binding]; other site 1009846004994 phosphorylation loop region [posttranslational modification] 1009846004995 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1009846004996 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1009846004997 alpha subunit interface [polypeptide binding]; other site 1009846004998 TPP binding site [chemical binding]; other site 1009846004999 heterodimer interface [polypeptide binding]; other site 1009846005000 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1009846005001 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1009846005002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846005003 E3 interaction surface; other site 1009846005004 lipoyl attachment site [posttranslational modification]; other site 1009846005005 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846005006 catalytic site [active] 1009846005007 lipoyl synthase; Provisional; Region: PRK12928 1009846005008 multidrug efflux protein; Reviewed; Region: PRK01766 1009846005009 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1009846005010 cation binding site [ion binding]; other site 1009846005011 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1009846005012 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1009846005013 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1009846005014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005015 putative substrate translocation pore; other site 1009846005016 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846005017 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1009846005018 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1009846005019 DNA binding residues [nucleotide binding] 1009846005020 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1009846005021 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1009846005022 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1009846005023 RNA binding site [nucleotide binding]; other site 1009846005024 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1009846005025 multimer interface [polypeptide binding]; other site 1009846005026 Walker A motif; other site 1009846005027 ATP binding site [chemical binding]; other site 1009846005028 Walker B motif; other site 1009846005029 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009846005030 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846005031 catalytic residues [active] 1009846005032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846005033 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1009846005034 Walker A motif; other site 1009846005035 ATP binding site [chemical binding]; other site 1009846005036 Walker B motif; other site 1009846005037 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 1009846005038 arginine finger; other site 1009846005039 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1009846005040 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1009846005041 hypothetical protein; Validated; Region: PRK00153 1009846005042 recombination protein RecR; Reviewed; Region: recR; PRK00076 1009846005043 RecR protein; Region: RecR; pfam02132 1009846005044 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1009846005045 putative active site [active] 1009846005046 putative metal-binding site [ion binding]; other site 1009846005047 tetramer interface [polypeptide binding]; other site 1009846005048 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846005049 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846005050 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1009846005051 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1009846005052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846005053 S-adenosylmethionine binding site [chemical binding]; other site 1009846005054 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846005055 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009846005056 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 1009846005057 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1009846005058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846005059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846005060 DNA binding residues [nucleotide binding] 1009846005061 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1009846005062 active site 1009846005063 catalytic site [active] 1009846005064 substrate binding site [chemical binding]; other site 1009846005065 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1009846005066 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1009846005067 putative catalytic site [active] 1009846005068 putative metal binding site [ion binding]; other site 1009846005069 putative phosphate binding site [ion binding]; other site 1009846005070 putative catalytic site [active] 1009846005071 putative phosphate binding site [ion binding]; other site 1009846005072 putative metal binding site [ion binding]; other site 1009846005073 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1009846005074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846005075 S-adenosylmethionine binding site [chemical binding]; other site 1009846005076 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1009846005077 YccA-like proteins; Region: YccA_like; cd10433 1009846005078 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1009846005079 active site 1009846005080 multimer interface [polypeptide binding]; other site 1009846005081 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1009846005082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846005083 FeS/SAM binding site; other site 1009846005084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846005085 non-specific DNA binding site [nucleotide binding]; other site 1009846005086 salt bridge; other site 1009846005087 sequence-specific DNA binding site [nucleotide binding]; other site 1009846005088 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1009846005089 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1009846005090 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1009846005091 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1009846005092 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1009846005093 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1009846005094 dimer interface [polypeptide binding]; other site 1009846005095 motif 1; other site 1009846005096 active site 1009846005097 motif 2; other site 1009846005098 motif 3; other site 1009846005099 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1009846005100 anticodon binding site; other site 1009846005101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1009846005102 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1009846005103 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1009846005104 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1009846005105 Trp docking motif [polypeptide binding]; other site 1009846005106 active site 1009846005107 GTP-binding protein Der; Reviewed; Region: PRK00093 1009846005108 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1009846005109 G1 box; other site 1009846005110 GTP/Mg2+ binding site [chemical binding]; other site 1009846005111 Switch I region; other site 1009846005112 G2 box; other site 1009846005113 Switch II region; other site 1009846005114 G3 box; other site 1009846005115 G4 box; other site 1009846005116 G5 box; other site 1009846005117 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1009846005118 G1 box; other site 1009846005119 GTP/Mg2+ binding site [chemical binding]; other site 1009846005120 Switch I region; other site 1009846005121 G2 box; other site 1009846005122 G3 box; other site 1009846005123 Switch II region; other site 1009846005124 G4 box; other site 1009846005125 G5 box; other site 1009846005126 bacterial Hfq-like; Region: Hfq; cd01716 1009846005127 hexamer interface [polypeptide binding]; other site 1009846005128 Sm1 motif; other site 1009846005129 RNA binding site [nucleotide binding]; other site 1009846005130 Sm2 motif; other site 1009846005131 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1009846005132 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1009846005133 HflX GTPase family; Region: HflX; cd01878 1009846005134 G1 box; other site 1009846005135 GTP/Mg2+ binding site [chemical binding]; other site 1009846005136 Switch I region; other site 1009846005137 G2 box; other site 1009846005138 G3 box; other site 1009846005139 Switch II region; other site 1009846005140 G4 box; other site 1009846005141 G5 box; other site 1009846005142 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1009846005143 HflK protein; Region: hflK; TIGR01933 1009846005144 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1009846005145 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1009846005146 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1009846005147 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1009846005148 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1009846005149 dimer interface [polypeptide binding]; other site 1009846005150 motif 1; other site 1009846005151 active site 1009846005152 motif 2; other site 1009846005153 motif 3; other site 1009846005154 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1009846005155 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1009846005156 GDP-binding site [chemical binding]; other site 1009846005157 ACT binding site; other site 1009846005158 IMP binding site; other site 1009846005159 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1009846005160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846005161 active site 1009846005162 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1009846005163 potassium uptake protein; Region: kup; TIGR00794 1009846005164 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1009846005165 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1009846005166 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1009846005167 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1009846005168 RNA binding site [nucleotide binding]; other site 1009846005169 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1009846005170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1009846005171 DEAD_2; Region: DEAD_2; pfam06733 1009846005172 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1009846005173 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1009846005174 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1009846005175 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1009846005176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846005177 RNA binding surface [nucleotide binding]; other site 1009846005178 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1009846005179 active site 1009846005180 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1009846005181 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1009846005182 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1009846005183 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1009846005184 putative acyltransferase; Provisional; Region: PRK05790 1009846005185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846005186 dimer interface [polypeptide binding]; other site 1009846005187 active site 1009846005188 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 1009846005189 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1009846005190 NAD(P) binding site [chemical binding]; other site 1009846005191 homotetramer interface [polypeptide binding]; other site 1009846005192 homodimer interface [polypeptide binding]; other site 1009846005193 active site 1009846005194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1009846005195 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1009846005196 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1009846005197 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1009846005198 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1009846005199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846005200 FeS/SAM binding site; other site 1009846005201 TRAM domain; Region: TRAM; cl01282 1009846005202 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1009846005203 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846005204 substrate binding site [chemical binding]; other site 1009846005205 ATP binding site [chemical binding]; other site 1009846005206 cystathionine beta-lyase; Provisional; Region: PRK07050 1009846005207 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846005208 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846005209 catalytic residue [active] 1009846005210 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 1009846005211 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1009846005212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846005213 motif II; other site 1009846005214 transcriptional activator TtdR; Provisional; Region: PRK09801 1009846005215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005216 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846005217 putative effector binding pocket; other site 1009846005218 dimerization interface [polypeptide binding]; other site 1009846005219 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1009846005220 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1009846005221 putative NAD(P) binding site [chemical binding]; other site 1009846005222 dimer interface [polypeptide binding]; other site 1009846005223 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 1009846005224 dimer interface [polypeptide binding]; other site 1009846005225 putative inhibitory loop; other site 1009846005226 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1009846005227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846005228 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1009846005229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846005230 Walker A/P-loop; other site 1009846005231 Walker A/P-loop; other site 1009846005232 ATP binding site [chemical binding]; other site 1009846005233 Q-loop/lid; other site 1009846005234 ABC transporter signature motif; other site 1009846005235 Walker B; other site 1009846005236 D-loop; other site 1009846005237 H-loop/switch region; other site 1009846005238 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1009846005239 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1009846005240 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1009846005241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846005242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846005243 ABC transporter; Region: ABC_tran_2; pfam12848 1009846005244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846005245 hypothetical protein; Provisional; Region: PRK11667 1009846005246 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1009846005247 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1009846005248 putative NAD(P) binding site [chemical binding]; other site 1009846005249 catalytic Zn binding site [ion binding]; other site 1009846005250 structural Zn binding site [ion binding]; other site 1009846005251 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846005252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846005253 putative DNA binding site [nucleotide binding]; other site 1009846005254 putative Zn2+ binding site [ion binding]; other site 1009846005255 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846005256 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1009846005257 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846005258 NAD binding site [chemical binding]; other site 1009846005259 catalytic residues [active] 1009846005260 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1009846005261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846005262 FMN binding site [chemical binding]; other site 1009846005263 substrate binding site [chemical binding]; other site 1009846005264 putative catalytic residue [active] 1009846005265 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1009846005266 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1009846005267 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1009846005268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846005269 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1009846005270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846005271 Walker A/P-loop; other site 1009846005272 ATP binding site [chemical binding]; other site 1009846005273 Q-loop/lid; other site 1009846005274 ABC transporter signature motif; other site 1009846005275 Walker B; other site 1009846005276 D-loop; other site 1009846005277 H-loop/switch region; other site 1009846005278 TOBE domain; Region: TOBE_2; pfam08402 1009846005279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005280 dimer interface [polypeptide binding]; other site 1009846005281 conserved gate region; other site 1009846005282 putative PBP binding loops; other site 1009846005283 ABC-ATPase subunit interface; other site 1009846005284 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846005285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005286 dimer interface [polypeptide binding]; other site 1009846005287 conserved gate region; other site 1009846005288 putative PBP binding loops; other site 1009846005289 ABC-ATPase subunit interface; other site 1009846005290 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1009846005291 Putative phosphatase (DUF442); Region: DUF442; cl17385 1009846005292 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1009846005293 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1009846005294 PAS fold; Region: PAS_4; pfam08448 1009846005295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846005296 putative active site [active] 1009846005297 heme pocket [chemical binding]; other site 1009846005298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846005299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1009846005300 Walker A motif; other site 1009846005301 ATP binding site [chemical binding]; other site 1009846005302 Walker B motif; other site 1009846005303 arginine finger; other site 1009846005304 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1009846005305 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009846005306 DNA binding residues [nucleotide binding] 1009846005307 putative dimer interface [polypeptide binding]; other site 1009846005308 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1009846005309 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1009846005310 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846005311 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1009846005312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846005313 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846005314 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846005315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846005316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846005317 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 1009846005318 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1009846005319 Cl- selectivity filter; other site 1009846005320 Cl- binding residues [ion binding]; other site 1009846005321 pore gating glutamate residue; other site 1009846005322 dimer interface [polypeptide binding]; other site 1009846005323 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1009846005324 Predicted membrane protein [Function unknown]; Region: COG2855 1009846005325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005326 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1009846005327 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1009846005328 putative dimerization interface [polypeptide binding]; other site 1009846005329 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1009846005330 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846005331 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1009846005332 substrate binding site [chemical binding]; other site 1009846005333 ATP binding site [chemical binding]; other site 1009846005334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005335 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846005336 putative substrate translocation pore; other site 1009846005337 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1009846005338 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1009846005339 dimerization interface [polypeptide binding]; other site 1009846005340 ligand binding site [chemical binding]; other site 1009846005341 NADP binding site [chemical binding]; other site 1009846005342 catalytic site [active] 1009846005343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846005344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846005345 DNA binding site [nucleotide binding] 1009846005346 domain linker motif; other site 1009846005347 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1009846005348 putative ligand binding site [chemical binding]; other site 1009846005349 putative dimerization interface [polypeptide binding]; other site 1009846005350 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1009846005351 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 1009846005352 PGDYG protein; Region: PGDYG; pfam14083 1009846005353 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1009846005354 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846005355 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846005356 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1009846005357 TrkA-N domain; Region: TrkA_N; pfam02254 1009846005358 AAA domain; Region: AAA_33; pfam13671 1009846005359 RNA helicase; Region: RNA_helicase; pfam00910 1009846005360 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1009846005361 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1009846005362 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1009846005363 oligomer interface [polypeptide binding]; other site 1009846005364 metal binding site [ion binding]; metal-binding site 1009846005365 metal binding site [ion binding]; metal-binding site 1009846005366 putative Cl binding site [ion binding]; other site 1009846005367 basic sphincter; other site 1009846005368 hydrophobic gate; other site 1009846005369 periplasmic entrance; other site 1009846005370 YciI-like protein; Reviewed; Region: PRK12866 1009846005371 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 1009846005372 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1009846005373 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1009846005374 dimer interface [polypeptide binding]; other site 1009846005375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846005376 catalytic residue [active] 1009846005377 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1009846005378 putative deacylase active site [active] 1009846005379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846005380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846005381 Coenzyme A binding pocket [chemical binding]; other site 1009846005382 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1009846005383 classical (c) SDRs; Region: SDR_c; cd05233 1009846005384 NAD(P) binding site [chemical binding]; other site 1009846005385 active site 1009846005386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846005387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005388 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846005389 putative effector binding pocket; other site 1009846005390 dimerization interface [polypeptide binding]; other site 1009846005391 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1009846005392 homotrimer interaction site [polypeptide binding]; other site 1009846005393 putative active site [active] 1009846005394 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1009846005395 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846005396 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846005397 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846005398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846005399 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846005400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846005401 putative Zn2+ binding site [ion binding]; other site 1009846005402 putative DNA binding site [nucleotide binding]; other site 1009846005403 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1009846005404 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1009846005405 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846005406 FMN binding site [chemical binding]; other site 1009846005407 substrate binding site [chemical binding]; other site 1009846005408 putative catalytic residue [active] 1009846005409 benzoate transport; Region: 2A0115; TIGR00895 1009846005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005411 putative substrate translocation pore; other site 1009846005412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005413 putative substrate translocation pore; other site 1009846005414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846005415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005416 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1009846005417 putative dimerization interface [polypeptide binding]; other site 1009846005418 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846005419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1009846005420 dimer interface [polypeptide binding]; other site 1009846005421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846005422 metal binding site [ion binding]; metal-binding site 1009846005423 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1009846005424 active site 1009846005425 catalytic residues [active] 1009846005426 metal binding site [ion binding]; metal-binding site 1009846005427 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846005428 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846005429 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1009846005430 glycerate dehydrogenase; Provisional; Region: PRK06487 1009846005431 putative ligand binding site [chemical binding]; other site 1009846005432 putative NAD binding site [chemical binding]; other site 1009846005433 catalytic site [active] 1009846005434 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846005435 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005437 dimer interface [polypeptide binding]; other site 1009846005438 conserved gate region; other site 1009846005439 putative PBP binding loops; other site 1009846005440 ABC-ATPase subunit interface; other site 1009846005441 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1009846005442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005443 dimer interface [polypeptide binding]; other site 1009846005444 conserved gate region; other site 1009846005445 putative PBP binding loops; other site 1009846005446 ABC-ATPase subunit interface; other site 1009846005447 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846005448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846005449 Walker A/P-loop; other site 1009846005450 ATP binding site [chemical binding]; other site 1009846005451 Q-loop/lid; other site 1009846005452 ABC transporter signature motif; other site 1009846005453 Walker B; other site 1009846005454 D-loop; other site 1009846005455 H-loop/switch region; other site 1009846005456 TOBE domain; Region: TOBE_2; pfam08402 1009846005457 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1009846005458 hypothetical protein; Provisional; Region: PRK11622 1009846005459 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1009846005460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005462 putative substrate translocation pore; other site 1009846005463 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1009846005464 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1009846005465 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1009846005466 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1009846005467 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1009846005468 NADP binding site [chemical binding]; other site 1009846005469 dimer interface [polypeptide binding]; other site 1009846005470 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1009846005471 AAA domain; Region: AAA_22; pfam13401 1009846005472 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846005473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846005474 DNA binding residues [nucleotide binding] 1009846005475 dimerization interface [polypeptide binding]; other site 1009846005476 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846005477 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846005478 trimer interface [polypeptide binding]; other site 1009846005479 eyelet of channel; other site 1009846005480 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846005481 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1009846005482 C-terminal domain interface [polypeptide binding]; other site 1009846005483 GSH binding site (G-site) [chemical binding]; other site 1009846005484 dimer interface [polypeptide binding]; other site 1009846005485 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1009846005486 dimer interface [polypeptide binding]; other site 1009846005487 N-terminal domain interface [polypeptide binding]; other site 1009846005488 MarR family; Region: MarR_2; cl17246 1009846005489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846005490 cyanate transporter; Region: CynX; TIGR00896 1009846005491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846005492 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1009846005493 active site 1009846005494 SAM binding site [chemical binding]; other site 1009846005495 homodimer interface [polypeptide binding]; other site 1009846005496 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1009846005497 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1009846005498 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1009846005499 active site 1009846005500 putative homodimer interface [polypeptide binding]; other site 1009846005501 SAM binding site [chemical binding]; other site 1009846005502 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1009846005503 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1009846005504 precorrin-3B synthase; Region: CobG; TIGR02435 1009846005505 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846005506 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846005507 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1009846005508 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1009846005509 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1009846005510 active site 1009846005511 SAM binding site [chemical binding]; other site 1009846005512 homodimer interface [polypeptide binding]; other site 1009846005513 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1009846005514 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1009846005515 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1009846005516 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1009846005517 active site 1009846005518 SAM binding site [chemical binding]; other site 1009846005519 homodimer interface [polypeptide binding]; other site 1009846005520 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846005521 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1009846005522 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846005523 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846005524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846005525 active site 1009846005526 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1009846005527 Citrate transporter; Region: CitMHS; pfam03600 1009846005528 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846005529 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846005530 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1009846005531 nudix motif; other site 1009846005532 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 1009846005533 active site 1009846005534 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1009846005535 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1009846005536 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1009846005537 metal ion-dependent adhesion site (MIDAS); other site 1009846005538 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1009846005539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846005540 Walker A motif; other site 1009846005541 ATP binding site [chemical binding]; other site 1009846005542 Walker B motif; other site 1009846005543 arginine finger; other site 1009846005544 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1009846005545 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1009846005546 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1009846005547 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1009846005548 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1009846005549 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1009846005550 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1009846005551 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1009846005552 active site 1009846005553 SAM binding site [chemical binding]; other site 1009846005554 homodimer interface [polypeptide binding]; other site 1009846005555 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 1009846005556 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1009846005557 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1009846005558 homodimer interface [polypeptide binding]; other site 1009846005559 Walker A motif; other site 1009846005560 ATP binding site [chemical binding]; other site 1009846005561 hydroxycobalamin binding site [chemical binding]; other site 1009846005562 Walker B motif; other site 1009846005563 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1009846005564 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846005565 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1009846005566 catalytic triad [active] 1009846005567 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1009846005568 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846005569 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1009846005570 metal binding site [ion binding]; metal-binding site 1009846005571 putative dimer interface [polypeptide binding]; other site 1009846005572 MarR family; Region: MarR_2; cl17246 1009846005573 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1009846005574 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1009846005575 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1009846005576 oligomeric interface; other site 1009846005577 putative active site [active] 1009846005578 homodimer interface [polypeptide binding]; other site 1009846005579 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1009846005580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1009846005581 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1009846005582 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1009846005583 catalytic site [active] 1009846005584 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1009846005585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846005586 N-terminal plug; other site 1009846005587 ligand-binding site [chemical binding]; other site 1009846005588 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1009846005589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846005590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1009846005591 Condensation domain; Region: Condensation; pfam00668 1009846005592 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1009846005593 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1009846005594 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1009846005595 acyl-activating enzyme (AAE) consensus motif; other site 1009846005596 AMP binding site [chemical binding]; other site 1009846005597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1009846005598 Condensation domain; Region: Condensation; pfam00668 1009846005599 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1009846005600 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1009846005601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1009846005602 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1009846005603 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1009846005604 acyl-activating enzyme (AAE) consensus motif; other site 1009846005605 AMP binding site [chemical binding]; other site 1009846005606 Condensation domain; Region: Condensation; pfam00668 1009846005607 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1009846005608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1009846005609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1009846005610 acyl-activating enzyme (AAE) consensus motif; other site 1009846005611 AMP binding site [chemical binding]; other site 1009846005612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1009846005613 Condensation domain; Region: Condensation; pfam00668 1009846005614 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1009846005615 Condensation domain; Region: Condensation; pfam00668 1009846005616 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1009846005617 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1009846005618 acyl-activating enzyme (AAE) consensus motif; other site 1009846005619 AMP binding site [chemical binding]; other site 1009846005620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1009846005621 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1009846005622 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1009846005623 Walker A/P-loop; other site 1009846005624 ATP binding site [chemical binding]; other site 1009846005625 Q-loop/lid; other site 1009846005626 ABC transporter signature motif; other site 1009846005627 Walker B; other site 1009846005628 D-loop; other site 1009846005629 H-loop/switch region; other site 1009846005630 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1009846005631 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1009846005632 siderophore binding site; other site 1009846005633 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1009846005634 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1009846005635 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1009846005636 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1009846005637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1009846005638 ABC-ATPase subunit interface; other site 1009846005639 dimer interface [polypeptide binding]; other site 1009846005640 putative PBP binding regions; other site 1009846005641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1009846005642 ABC-ATPase subunit interface; other site 1009846005643 dimer interface [polypeptide binding]; other site 1009846005644 putative PBP binding regions; other site 1009846005645 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1009846005646 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1009846005647 Walker A/P-loop; other site 1009846005648 ATP binding site [chemical binding]; other site 1009846005649 Q-loop/lid; other site 1009846005650 ABC transporter signature motif; other site 1009846005651 Walker B; other site 1009846005652 D-loop; other site 1009846005653 H-loop/switch region; other site 1009846005654 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1009846005655 MbtH-like protein; Region: MbtH; cl01279 1009846005656 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1009846005657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846005658 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1009846005659 Fimbrial protein; Region: Fimbrial; pfam00419 1009846005660 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1009846005661 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846005662 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1009846005663 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1009846005664 PapC N-terminal domain; Region: PapC_N; pfam13954 1009846005665 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846005666 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846005667 Fimbrial protein; Region: Fimbrial; cl01416 1009846005668 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846005669 multidrug efflux protein; Reviewed; Region: PRK09577 1009846005670 Protein export membrane protein; Region: SecD_SecF; cl14618 1009846005671 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1009846005672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846005673 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846005674 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1009846005675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846005676 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1009846005677 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1009846005678 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009846005679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005680 dimer interface [polypeptide binding]; other site 1009846005681 conserved gate region; other site 1009846005682 putative PBP binding loops; other site 1009846005683 ABC-ATPase subunit interface; other site 1009846005684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005685 dimer interface [polypeptide binding]; other site 1009846005686 conserved gate region; other site 1009846005687 putative PBP binding loops; other site 1009846005688 ABC-ATPase subunit interface; other site 1009846005689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846005690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846005691 substrate binding pocket [chemical binding]; other site 1009846005692 membrane-bound complex binding site; other site 1009846005693 hinge residues; other site 1009846005694 Serine hydrolase; Region: Ser_hydrolase; cl17834 1009846005695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846005696 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1009846005697 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1009846005698 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1009846005699 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1009846005700 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1009846005701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846005702 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1009846005703 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1009846005704 putative active site; other site 1009846005705 catalytic triad [active] 1009846005706 putative dimer interface [polypeptide binding]; other site 1009846005707 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1009846005708 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1009846005709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846005710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005711 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1009846005712 dimerization interface [polypeptide binding]; other site 1009846005713 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1009846005714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005715 putative substrate translocation pore; other site 1009846005716 SpoVR family protein; Provisional; Region: PRK11767 1009846005717 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1009846005718 hypothetical protein; Provisional; Region: PRK05325 1009846005719 PrkA family serine protein kinase; Provisional; Region: PRK15455 1009846005720 AAA ATPase domain; Region: AAA_16; pfam13191 1009846005721 Walker A motif; other site 1009846005722 ATP binding site [chemical binding]; other site 1009846005723 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1009846005724 Tar ligand binding domain homologue; Region: TarH; pfam02203 1009846005725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846005726 dimer interface [polypeptide binding]; other site 1009846005727 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1009846005728 putative CheW interface [polypeptide binding]; other site 1009846005729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846005730 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1009846005731 substrate binding site [chemical binding]; other site 1009846005732 dimer interface [polypeptide binding]; other site 1009846005733 ATP binding site [chemical binding]; other site 1009846005734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846005735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846005736 DNA binding site [nucleotide binding] 1009846005737 domain linker motif; other site 1009846005738 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009846005739 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846005740 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846005741 TM-ABC transporter signature motif; other site 1009846005742 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009846005743 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846005744 Walker A/P-loop; other site 1009846005745 ATP binding site [chemical binding]; other site 1009846005746 Q-loop/lid; other site 1009846005747 ABC transporter signature motif; other site 1009846005748 Walker B; other site 1009846005749 D-loop; other site 1009846005750 H-loop/switch region; other site 1009846005751 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846005752 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1009846005753 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009846005754 ligand binding site [chemical binding]; other site 1009846005755 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 1009846005756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005757 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1009846005758 substrate binding site [chemical binding]; other site 1009846005759 dimerization interface [polypeptide binding]; other site 1009846005760 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1009846005761 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1009846005762 Walker A/P-loop; other site 1009846005763 ATP binding site [chemical binding]; other site 1009846005764 Q-loop/lid; other site 1009846005765 ABC transporter signature motif; other site 1009846005766 Walker B; other site 1009846005767 D-loop; other site 1009846005768 H-loop/switch region; other site 1009846005769 TOBE-like domain; Region: TOBE_3; pfam12857 1009846005770 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1009846005771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005772 dimer interface [polypeptide binding]; other site 1009846005773 conserved gate region; other site 1009846005774 putative PBP binding loops; other site 1009846005775 ABC-ATPase subunit interface; other site 1009846005776 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1009846005777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005778 dimer interface [polypeptide binding]; other site 1009846005779 conserved gate region; other site 1009846005780 putative PBP binding loops; other site 1009846005781 ABC-ATPase subunit interface; other site 1009846005782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846005783 substrate binding pocket [chemical binding]; other site 1009846005784 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846005785 membrane-bound complex binding site; other site 1009846005786 LexA repressor; Validated; Region: PRK00215 1009846005787 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1009846005788 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1009846005789 Catalytic site [active] 1009846005790 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 1009846005791 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846005792 Ligand Binding Site [chemical binding]; other site 1009846005793 nodulation ABC transporter NodI; Provisional; Region: PRK13537 1009846005794 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1009846005795 Walker A/P-loop; other site 1009846005796 ATP binding site [chemical binding]; other site 1009846005797 Q-loop/lid; other site 1009846005798 ABC transporter signature motif; other site 1009846005799 Walker B; other site 1009846005800 D-loop; other site 1009846005801 H-loop/switch region; other site 1009846005802 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009846005803 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1009846005804 Predicted permease; Region: DUF318; cl17795 1009846005805 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1009846005806 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1009846005807 active site residue [active] 1009846005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846005809 Walker A/P-loop; other site 1009846005810 ATP binding site [chemical binding]; other site 1009846005811 Q-loop/lid; other site 1009846005812 ABC transporter signature motif; other site 1009846005813 Walker B; other site 1009846005814 D-loop; other site 1009846005815 H-loop/switch region; other site 1009846005816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846005817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846005818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846005819 dimerization interface [polypeptide binding]; other site 1009846005820 hypothetical protein; Provisional; Region: PRK07079 1009846005821 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1009846005822 metal binding site [ion binding]; metal-binding site 1009846005823 putative dimer interface [polypeptide binding]; other site 1009846005824 citrate-proton symporter; Provisional; Region: PRK15075 1009846005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005826 putative substrate translocation pore; other site 1009846005827 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846005828 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846005829 active site 1009846005830 catalytic tetrad [active] 1009846005831 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1009846005832 CoenzymeA binding site [chemical binding]; other site 1009846005833 subunit interaction site [polypeptide binding]; other site 1009846005834 PHB binding site; other site 1009846005835 Predicted transcriptional regulators [Transcription]; Region: COG1733 1009846005836 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1009846005837 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1009846005838 PLD-like domain; Region: PLDc_2; pfam13091 1009846005839 putative active site [active] 1009846005840 catalytic site [active] 1009846005841 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1009846005842 putative dimer interface [polypeptide binding]; other site 1009846005843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846005844 Family of unknown function (DUF695); Region: DUF695; pfam05117 1009846005845 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1009846005846 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1009846005847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846005848 Coenzyme A binding pocket [chemical binding]; other site 1009846005849 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 1009846005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846005851 S-adenosylmethionine binding site [chemical binding]; other site 1009846005852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846005853 S-adenosylmethionine binding site [chemical binding]; other site 1009846005854 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1009846005855 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1009846005856 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009846005857 active site 1009846005858 DNA binding site [nucleotide binding] 1009846005859 Int/Topo IB signature motif; other site 1009846005860 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1009846005861 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1009846005862 FMN binding site [chemical binding]; other site 1009846005863 active site 1009846005864 catalytic residues [active] 1009846005865 substrate binding site [chemical binding]; other site 1009846005866 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1009846005867 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1009846005868 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846005869 Walker A/P-loop; other site 1009846005870 ATP binding site [chemical binding]; other site 1009846005871 Q-loop/lid; other site 1009846005872 ABC transporter signature motif; other site 1009846005873 Walker B; other site 1009846005874 D-loop; other site 1009846005875 H-loop/switch region; other site 1009846005876 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846005877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005878 dimer interface [polypeptide binding]; other site 1009846005879 conserved gate region; other site 1009846005880 putative PBP binding loops; other site 1009846005881 ABC-ATPase subunit interface; other site 1009846005882 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1009846005883 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1009846005884 active site 1009846005885 dimer interface [polypeptide binding]; other site 1009846005886 non-prolyl cis peptide bond; other site 1009846005887 insertion regions; other site 1009846005888 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1009846005889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846005890 substrate binding site [chemical binding]; other site 1009846005891 oxyanion hole (OAH) forming residues; other site 1009846005892 trimer interface [polypeptide binding]; other site 1009846005893 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1009846005894 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1009846005895 hypothetical protein; Provisional; Region: PRK02487 1009846005896 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1009846005897 nudix motif; other site 1009846005898 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1009846005899 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1009846005900 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1009846005901 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1009846005902 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1009846005903 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1009846005904 quinone interaction residues [chemical binding]; other site 1009846005905 active site 1009846005906 catalytic residues [active] 1009846005907 FMN binding site [chemical binding]; other site 1009846005908 substrate binding site [chemical binding]; other site 1009846005909 cystine transporter subunit; Provisional; Region: PRK11260 1009846005910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846005911 substrate binding pocket [chemical binding]; other site 1009846005912 membrane-bound complex binding site; other site 1009846005913 hinge residues; other site 1009846005914 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846005915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846005916 dimer interface [polypeptide binding]; other site 1009846005917 conserved gate region; other site 1009846005918 putative PBP binding loops; other site 1009846005919 ABC-ATPase subunit interface; other site 1009846005920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846005921 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846005922 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846005923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846005924 DNA-binding site [nucleotide binding]; DNA binding site 1009846005925 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846005926 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1009846005927 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1009846005928 active site 1009846005929 dimer interface [polypeptide binding]; other site 1009846005930 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1009846005931 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1009846005932 amidase catalytic site [active] 1009846005933 Zn binding residues [ion binding]; other site 1009846005934 substrate binding site [chemical binding]; other site 1009846005935 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1009846005936 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1009846005937 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1009846005938 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1009846005939 ribonuclease R; Region: RNase_R; TIGR02063 1009846005940 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1009846005941 RNB domain; Region: RNB; pfam00773 1009846005942 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1009846005943 RNA binding site [nucleotide binding]; other site 1009846005944 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009846005945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846005946 substrate binding pocket [chemical binding]; other site 1009846005947 membrane-bound complex binding site; other site 1009846005948 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846005949 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1009846005950 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009846005951 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009846005952 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846005953 Walker A/P-loop; other site 1009846005954 ATP binding site [chemical binding]; other site 1009846005955 Q-loop/lid; other site 1009846005956 ABC transporter signature motif; other site 1009846005957 Walker B; other site 1009846005958 D-loop; other site 1009846005959 H-loop/switch region; other site 1009846005960 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846005961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846005962 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846005963 TM-ABC transporter signature motif; other site 1009846005964 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1009846005965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009846005966 putative ligand binding site [chemical binding]; other site 1009846005967 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1009846005968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846005969 putative substrate binding site [chemical binding]; other site 1009846005970 putative ATP binding site [chemical binding]; other site 1009846005971 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1009846005972 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1009846005973 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1009846005974 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1009846005975 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 1009846005976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846005977 putative sialic acid transporter; Region: 2A0112; TIGR00891 1009846005978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846005979 putative substrate translocation pore; other site 1009846005980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846005981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846005982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1009846005983 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1009846005984 acyl-activating enzyme (AAE) consensus motif; other site 1009846005985 putative AMP binding site [chemical binding]; other site 1009846005986 putative active site [active] 1009846005987 putative CoA binding site [chemical binding]; other site 1009846005988 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 1009846005989 bacterial Hfq-like; Region: Hfq; cd01716 1009846005990 hexamer interface [polypeptide binding]; other site 1009846005991 Sm1 motif; other site 1009846005992 RNA binding site [nucleotide binding]; other site 1009846005993 Sm2 motif; other site 1009846005994 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1009846005995 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1009846005996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846005997 Walker A motif; other site 1009846005998 ATP binding site [chemical binding]; other site 1009846005999 Walker B motif; other site 1009846006000 arginine finger; other site 1009846006001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846006002 Predicted membrane protein [Function unknown]; Region: COG4655 1009846006003 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1009846006004 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1009846006005 TPR repeat; Region: TPR_11; pfam13414 1009846006006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846006007 binding surface 1009846006008 TPR motif; other site 1009846006009 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1009846006010 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846006011 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1009846006012 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846006013 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1009846006014 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1009846006015 ATP binding site [chemical binding]; other site 1009846006016 Walker A motif; other site 1009846006017 hexamer interface [polypeptide binding]; other site 1009846006018 Walker B motif; other site 1009846006019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1009846006020 active site 1009846006021 phosphorylation site [posttranslational modification] 1009846006022 intermolecular recognition site; other site 1009846006023 AAA domain; Region: AAA_31; pfam13614 1009846006024 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1009846006025 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846006026 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1009846006027 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1009846006028 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1009846006029 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1009846006030 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1009846006031 TadE-like protein; Region: TadE; pfam07811 1009846006032 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1009846006033 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1009846006034 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1009846006035 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1009846006036 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1009846006037 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1009846006038 Predicted ATPase [General function prediction only]; Region: COG1485 1009846006039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846006040 Walker B; other site 1009846006041 D-loop; other site 1009846006042 H-loop/switch region; other site 1009846006043 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1009846006044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846006045 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009846006046 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1009846006047 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846006048 E3 interaction surface; other site 1009846006049 lipoyl attachment site [posttranslational modification]; other site 1009846006050 e3 binding domain; Region: E3_binding; pfam02817 1009846006051 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1009846006052 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1009846006053 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1009846006054 TPP-binding site [chemical binding]; other site 1009846006055 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1009846006056 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1009846006057 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1009846006058 G1 box; other site 1009846006059 putative GEF interaction site [polypeptide binding]; other site 1009846006060 GTP/Mg2+ binding site [chemical binding]; other site 1009846006061 Switch I region; other site 1009846006062 G2 box; other site 1009846006063 G3 box; other site 1009846006064 Switch II region; other site 1009846006065 G4 box; other site 1009846006066 G5 box; other site 1009846006067 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1009846006068 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1009846006069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846006070 MarR family; Region: MarR_2; cl17246 1009846006071 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846006072 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1009846006073 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846006074 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846006075 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846006076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006077 putative substrate translocation pore; other site 1009846006078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006079 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 1009846006080 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1009846006081 RNA binding site [nucleotide binding]; other site 1009846006082 active site 1009846006083 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1009846006084 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1009846006085 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1009846006086 translation initiation factor IF-2; Region: IF-2; TIGR00487 1009846006087 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1009846006088 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1009846006089 G1 box; other site 1009846006090 putative GEF interaction site [polypeptide binding]; other site 1009846006091 GTP/Mg2+ binding site [chemical binding]; other site 1009846006092 Switch I region; other site 1009846006093 G2 box; other site 1009846006094 G3 box; other site 1009846006095 Switch II region; other site 1009846006096 G4 box; other site 1009846006097 G5 box; other site 1009846006098 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1009846006099 Translation-initiation factor 2; Region: IF-2; pfam11987 1009846006100 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1009846006101 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1009846006102 NusA N-terminal domain; Region: NusA_N; pfam08529 1009846006103 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1009846006104 RNA binding site [nucleotide binding]; other site 1009846006105 homodimer interface [polypeptide binding]; other site 1009846006106 NusA-like KH domain; Region: KH_5; pfam13184 1009846006107 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1009846006108 G-X-X-G motif; other site 1009846006109 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1009846006110 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1009846006111 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1009846006112 Sm and related proteins; Region: Sm_like; cl00259 1009846006113 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1009846006114 putative oligomer interface [polypeptide binding]; other site 1009846006115 putative RNA binding site [nucleotide binding]; other site 1009846006116 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1009846006117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846006118 RNA binding surface [nucleotide binding]; other site 1009846006119 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1009846006120 probable active site [active] 1009846006121 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1009846006122 aspartate aminotransferase; Provisional; Region: PRK06108 1009846006123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846006124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846006125 homodimer interface [polypeptide binding]; other site 1009846006126 catalytic residue [active] 1009846006127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006129 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1009846006130 putative dimerization interface [polypeptide binding]; other site 1009846006131 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1009846006132 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1009846006133 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1009846006134 putative active site [active] 1009846006135 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1009846006136 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1009846006137 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1009846006138 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1009846006139 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009846006140 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1009846006141 DNA binding residues [nucleotide binding] 1009846006142 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1009846006143 IHF dimer interface [polypeptide binding]; other site 1009846006144 IHF - DNA interface [nucleotide binding]; other site 1009846006145 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1009846006146 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1009846006147 putative tRNA-binding site [nucleotide binding]; other site 1009846006148 B3/4 domain; Region: B3_4; pfam03483 1009846006149 tRNA synthetase B5 domain; Region: B5; smart00874 1009846006150 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1009846006151 dimer interface [polypeptide binding]; other site 1009846006152 motif 1; other site 1009846006153 motif 3; other site 1009846006154 motif 2; other site 1009846006155 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1009846006156 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1009846006157 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1009846006158 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1009846006159 dimer interface [polypeptide binding]; other site 1009846006160 motif 1; other site 1009846006161 active site 1009846006162 motif 2; other site 1009846006163 motif 3; other site 1009846006164 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1009846006165 23S rRNA binding site [nucleotide binding]; other site 1009846006166 L21 binding site [polypeptide binding]; other site 1009846006167 L13 binding site [polypeptide binding]; other site 1009846006168 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1009846006169 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1009846006170 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1009846006171 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1009846006172 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1009846006173 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1009846006174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1009846006175 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1009846006176 active site 1009846006177 dimer interface [polypeptide binding]; other site 1009846006178 motif 1; other site 1009846006179 motif 2; other site 1009846006180 motif 3; other site 1009846006181 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1009846006182 anticodon binding site; other site 1009846006183 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1009846006184 HD domain; Region: HD_4; pfam13328 1009846006185 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1009846006186 synthetase active site [active] 1009846006187 NTP binding site [chemical binding]; other site 1009846006188 metal binding site [ion binding]; metal-binding site 1009846006189 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1009846006190 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1009846006191 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1009846006192 homotrimer interaction site [polypeptide binding]; other site 1009846006193 putative active site [active] 1009846006194 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846006195 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846006196 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1009846006197 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1009846006198 PAS domain; Region: PAS_9; pfam13426 1009846006199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846006200 putative active site [active] 1009846006201 heme pocket [chemical binding]; other site 1009846006202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846006203 DNA binding residues [nucleotide binding] 1009846006204 dimerization interface [polypeptide binding]; other site 1009846006205 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1009846006206 active site 1009846006207 short chain dehydrogenase; Provisional; Region: PRK06949 1009846006208 classical (c) SDRs; Region: SDR_c; cd05233 1009846006209 NAD(P) binding site [chemical binding]; other site 1009846006210 active site 1009846006211 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1009846006212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846006213 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1009846006214 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846006215 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009846006216 inhibitor site; inhibition site 1009846006217 active site 1009846006218 dimer interface [polypeptide binding]; other site 1009846006219 catalytic residue [active] 1009846006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006221 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846006222 putative substrate translocation pore; other site 1009846006223 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1009846006224 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846006225 substrate binding site [chemical binding]; other site 1009846006226 dimer interface [polypeptide binding]; other site 1009846006227 ATP binding site [chemical binding]; other site 1009846006228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846006229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846006230 DNA binding site [nucleotide binding] 1009846006231 domain linker motif; other site 1009846006232 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 1009846006233 putative dimerization interface [polypeptide binding]; other site 1009846006234 putative ligand binding site [chemical binding]; other site 1009846006235 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1009846006236 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1009846006237 Tetramer interface [polypeptide binding]; other site 1009846006238 active site 1009846006239 FMN-binding site [chemical binding]; other site 1009846006240 H+ Antiporter protein; Region: 2A0121; TIGR00900 1009846006241 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009846006242 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009846006243 putative acyl-acceptor binding pocket; other site 1009846006244 FOG: CBS domain [General function prediction only]; Region: COG0517 1009846006245 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1009846006246 Protein of unknown function (DUF962); Region: DUF962; cl01879 1009846006247 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1009846006248 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1009846006249 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846006250 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846006251 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1009846006252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846006253 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1009846006254 putative active site [active] 1009846006255 putative metal binding site [ion binding]; other site 1009846006256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006258 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846006259 putative effector binding pocket; other site 1009846006260 dimerization interface [polypeptide binding]; other site 1009846006261 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846006262 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1009846006263 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846006264 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1009846006265 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1009846006266 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846006267 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846006268 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1009846006269 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846006270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846006271 dimer interface [polypeptide binding]; other site 1009846006272 putative CheW interface [polypeptide binding]; other site 1009846006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846006275 putative substrate translocation pore; other site 1009846006276 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1009846006277 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1009846006278 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1009846006279 Part of AAA domain; Region: AAA_19; pfam13245 1009846006280 Family description; Region: UvrD_C_2; pfam13538 1009846006281 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1009846006282 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1009846006283 HIGH motif; other site 1009846006284 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1009846006285 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1009846006286 active site 1009846006287 KMSKS motif; other site 1009846006288 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1009846006289 tRNA binding surface [nucleotide binding]; other site 1009846006290 anticodon binding site; other site 1009846006291 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1009846006292 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1009846006293 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1009846006294 active site 1009846006295 tetramer interface; other site 1009846006296 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1009846006297 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1009846006298 CHASE2 domain; Region: CHASE2; pfam05226 1009846006299 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1009846006300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846006301 dimer interface [polypeptide binding]; other site 1009846006302 phosphorylation site [posttranslational modification] 1009846006303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846006304 ATP binding site [chemical binding]; other site 1009846006305 Mg2+ binding site [ion binding]; other site 1009846006306 G-X-G motif; other site 1009846006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 1009846006308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846006309 FecR protein; Region: FecR; pfam04773 1009846006310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846006311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846006312 active site 1009846006313 phosphorylation site [posttranslational modification] 1009846006314 intermolecular recognition site; other site 1009846006315 dimerization interface [polypeptide binding]; other site 1009846006316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846006317 DNA binding site [nucleotide binding] 1009846006318 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1009846006319 CPxP motif; other site 1009846006320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006322 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846006323 putative effector binding pocket; other site 1009846006324 dimerization interface [polypeptide binding]; other site 1009846006325 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1009846006326 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1009846006327 tetrameric interface [polypeptide binding]; other site 1009846006328 NAD binding site [chemical binding]; other site 1009846006329 catalytic residues [active] 1009846006330 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846006331 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846006332 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846006333 putative active site [active] 1009846006334 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846006335 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846006336 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1009846006337 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1009846006338 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846006339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846006340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1009846006341 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1009846006342 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1009846006343 DNA interaction; other site 1009846006344 Metal-binding active site; metal-binding site 1009846006345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846006346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846006347 TM-ABC transporter signature motif; other site 1009846006348 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009846006349 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846006350 Walker A/P-loop; other site 1009846006351 ATP binding site [chemical binding]; other site 1009846006352 Q-loop/lid; other site 1009846006353 ABC transporter signature motif; other site 1009846006354 Walker B; other site 1009846006355 D-loop; other site 1009846006356 H-loop/switch region; other site 1009846006357 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846006358 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1009846006359 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009846006360 putative ligand binding site [chemical binding]; other site 1009846006361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846006362 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1009846006363 substrate binding site [chemical binding]; other site 1009846006364 ATP binding site [chemical binding]; other site 1009846006365 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1009846006366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1009846006367 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1009846006368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846006369 dimer interface [polypeptide binding]; other site 1009846006370 PYR/PP interface [polypeptide binding]; other site 1009846006371 TPP binding site [chemical binding]; other site 1009846006372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846006373 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1009846006374 TPP-binding site [chemical binding]; other site 1009846006375 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1009846006376 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1009846006377 hypothetical protein; Provisional; Region: PRK02487 1009846006378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1009846006379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846006380 NAD(P) binding site [chemical binding]; other site 1009846006381 active site 1009846006382 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846006383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846006384 Walker A/P-loop; other site 1009846006385 ATP binding site [chemical binding]; other site 1009846006386 Q-loop/lid; other site 1009846006387 ABC transporter signature motif; other site 1009846006388 Walker B; other site 1009846006389 D-loop; other site 1009846006390 H-loop/switch region; other site 1009846006391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846006392 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846006393 Walker A/P-loop; other site 1009846006394 ATP binding site [chemical binding]; other site 1009846006395 Q-loop/lid; other site 1009846006396 ABC transporter signature motif; other site 1009846006397 Walker B; other site 1009846006398 D-loop; other site 1009846006399 H-loop/switch region; other site 1009846006400 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1009846006401 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846006402 TM-ABC transporter signature motif; other site 1009846006403 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846006404 TM-ABC transporter signature motif; other site 1009846006405 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1009846006406 active site 1009846006407 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1009846006408 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1009846006409 nudix motif; other site 1009846006410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006411 putative substrate translocation pore; other site 1009846006412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846006415 dimerization interface [polypeptide binding]; other site 1009846006416 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1009846006417 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1009846006418 motif 1; other site 1009846006419 active site 1009846006420 motif 2; other site 1009846006421 motif 3; other site 1009846006422 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1009846006423 DHHA1 domain; Region: DHHA1; pfam02272 1009846006424 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846006425 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846006426 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1009846006427 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1009846006428 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009846006429 active site 1009846006430 HIGH motif; other site 1009846006431 nucleotide binding site [chemical binding]; other site 1009846006432 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1009846006433 KMSKS motif; other site 1009846006434 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1009846006435 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1009846006436 nudix motif; other site 1009846006437 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1009846006438 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1009846006439 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1009846006440 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1009846006441 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1009846006442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846006443 Predicted membrane protein [Function unknown]; Region: COG2259 1009846006444 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1009846006445 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1009846006446 active site 1009846006447 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1009846006448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006450 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846006451 putative effector binding pocket; other site 1009846006452 dimerization interface [polypeptide binding]; other site 1009846006453 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1009846006454 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846006455 catalytic triad [active] 1009846006456 dimer interface [polypeptide binding]; other site 1009846006457 conserved cis-peptide bond; other site 1009846006458 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1009846006459 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1009846006460 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1009846006461 Pirin-related protein [General function prediction only]; Region: COG1741 1009846006462 Pirin; Region: Pirin; pfam02678 1009846006463 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1009846006464 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1009846006465 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1009846006466 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1009846006467 DXD motif; other site 1009846006468 PilZ domain; Region: PilZ; pfam07238 1009846006469 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1009846006470 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 1009846006471 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1009846006472 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1009846006473 cellulose synthase regulator protein; Provisional; Region: PRK11114 1009846006474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846006475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846006476 metal binding site [ion binding]; metal-binding site 1009846006477 active site 1009846006478 I-site; other site 1009846006479 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1009846006480 active site 1009846006481 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1009846006482 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846006483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846006484 S-adenosylmethionine binding site [chemical binding]; other site 1009846006485 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1009846006486 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009846006487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009846006488 putative acyl-acceptor binding pocket; other site 1009846006489 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1009846006490 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1009846006491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846006492 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846006493 DNA binding residues [nucleotide binding] 1009846006494 dimerization interface [polypeptide binding]; other site 1009846006495 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1009846006496 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1009846006497 putative active site [active] 1009846006498 catalytic triad [active] 1009846006499 putative dimer interface [polypeptide binding]; other site 1009846006500 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1009846006501 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1009846006502 Citrate transporter; Region: CitMHS; pfam03600 1009846006503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006505 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1009846006506 putative dimerization interface [polypeptide binding]; other site 1009846006507 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1009846006508 Secretin and TonB N terminus short domain; Region: STN; smart00965 1009846006509 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1009846006510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846006511 N-terminal plug; other site 1009846006512 ligand-binding site [chemical binding]; other site 1009846006513 fec operon regulator FecR; Reviewed; Region: PRK09774 1009846006514 FecR protein; Region: FecR; pfam04773 1009846006515 RNA polymerase sigma factor; Provisional; Region: PRK12528 1009846006516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846006517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846006518 DNA binding residues [nucleotide binding] 1009846006519 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846006520 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846006521 trimer interface [polypeptide binding]; other site 1009846006522 eyelet of channel; other site 1009846006523 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846006524 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846006525 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846006526 catalytic residue [active] 1009846006527 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1009846006528 VirB7 interaction site; other site 1009846006529 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1009846006530 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1009846006531 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1009846006532 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1009846006533 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1009846006534 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1009846006535 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846006536 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846006537 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1009846006538 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1009846006539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1009846006540 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846006541 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846006542 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1009846006543 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1009846006544 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1009846006545 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1009846006546 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1009846006547 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1009846006548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1009846006549 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846006550 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846006551 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1009846006552 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1009846006553 PAAR motif; Region: PAAR_motif; pfam05488 1009846006554 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1009846006555 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1009846006556 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1009846006557 MltA-interacting protein MipA; Region: MipA; cl01504 1009846006558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846006559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846006560 active site 1009846006561 phosphorylation site [posttranslational modification] 1009846006562 intermolecular recognition site; other site 1009846006563 dimerization interface [polypeptide binding]; other site 1009846006564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846006565 DNA binding site [nucleotide binding] 1009846006566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846006567 dimerization interface [polypeptide binding]; other site 1009846006568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1009846006569 dimer interface [polypeptide binding]; other site 1009846006570 phosphorylation site [posttranslational modification] 1009846006571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846006572 ATP binding site [chemical binding]; other site 1009846006573 Mg2+ binding site [ion binding]; other site 1009846006574 G-X-G motif; other site 1009846006575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846006577 putative substrate translocation pore; other site 1009846006578 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846006579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846006580 trimer interface [polypeptide binding]; other site 1009846006581 eyelet of channel; other site 1009846006582 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 1009846006583 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1009846006584 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846006585 active site 1009846006586 metal binding site [ion binding]; metal-binding site 1009846006587 hypothetical protein; Provisional; Region: PRK06126 1009846006588 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846006589 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846006590 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846006591 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846006592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846006593 DNA-binding site [nucleotide binding]; DNA binding site 1009846006594 FCD domain; Region: FCD; pfam07729 1009846006595 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846006596 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1009846006597 catalytic triad [active] 1009846006598 dimer interface [polypeptide binding]; other site 1009846006599 conserved cis-peptide bond; other site 1009846006600 Predicted membrane protein [Function unknown]; Region: COG2259 1009846006601 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1009846006602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006604 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846006605 putative effector binding pocket; other site 1009846006606 dimerization interface [polypeptide binding]; other site 1009846006607 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1009846006608 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846006609 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 1009846006610 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1009846006611 HlyD family secretion protein; Region: HlyD; pfam00529 1009846006612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846006613 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846006614 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846006615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1009846006616 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846006617 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846006618 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846006619 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1009846006620 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1009846006621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846006622 active site 1009846006623 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1009846006624 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846006625 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1009846006626 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1009846006627 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846006628 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846006629 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1009846006630 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846006631 catalytic loop [active] 1009846006632 iron binding site [ion binding]; other site 1009846006633 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1009846006634 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1009846006635 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846006636 putative NAD(P) binding site [chemical binding]; other site 1009846006637 substrate binding site [chemical binding]; other site 1009846006638 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1009846006639 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1009846006640 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1009846006641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1009846006642 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846006643 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846006644 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1009846006645 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1009846006646 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1009846006647 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1009846006648 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1009846006649 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1009846006650 active site 1009846006651 Mg2+ binding site [ion binding]; other site 1009846006652 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1009846006653 HTH-like domain; Region: HTH_21; pfam13276 1009846006654 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1009846006655 DNA-binding interface [nucleotide binding]; DNA binding site 1009846006656 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1009846006657 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1009846006658 active site 1009846006659 catalytic residues [active] 1009846006660 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846006661 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1009846006662 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009846006663 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1009846006664 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1009846006665 active site 1009846006666 acyl-activating enzyme (AAE) consensus motif; other site 1009846006667 putative CoA binding site [chemical binding]; other site 1009846006668 AMP binding site [chemical binding]; other site 1009846006669 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1009846006670 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1009846006671 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1009846006672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1009846006673 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1009846006674 catalytic core [active] 1009846006675 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1009846006676 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1009846006677 polyphosphate kinase; Provisional; Region: PRK05443 1009846006678 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1009846006679 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1009846006680 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1009846006681 putative active site [active] 1009846006682 catalytic site [active] 1009846006683 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1009846006684 putative domain interface [polypeptide binding]; other site 1009846006685 putative active site [active] 1009846006686 catalytic site [active] 1009846006687 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1009846006688 PAS domain; Region: PAS; smart00091 1009846006689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846006690 dimer interface [polypeptide binding]; other site 1009846006691 phosphorylation site [posttranslational modification] 1009846006692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846006693 ATP binding site [chemical binding]; other site 1009846006694 Mg2+ binding site [ion binding]; other site 1009846006695 G-X-G motif; other site 1009846006696 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1009846006697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846006698 active site 1009846006699 phosphorylation site [posttranslational modification] 1009846006700 intermolecular recognition site; other site 1009846006701 dimerization interface [polypeptide binding]; other site 1009846006702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846006703 DNA binding site [nucleotide binding] 1009846006704 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1009846006705 PhoU domain; Region: PhoU; pfam01895 1009846006706 PhoU domain; Region: PhoU; pfam01895 1009846006707 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1009846006708 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1009846006709 Walker A/P-loop; other site 1009846006710 ATP binding site [chemical binding]; other site 1009846006711 Q-loop/lid; other site 1009846006712 ABC transporter signature motif; other site 1009846006713 Walker B; other site 1009846006714 D-loop; other site 1009846006715 H-loop/switch region; other site 1009846006716 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1009846006717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846006718 dimer interface [polypeptide binding]; other site 1009846006719 conserved gate region; other site 1009846006720 putative PBP binding loops; other site 1009846006721 ABC-ATPase subunit interface; other site 1009846006722 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1009846006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846006724 dimer interface [polypeptide binding]; other site 1009846006725 conserved gate region; other site 1009846006726 ABC-ATPase subunit interface; other site 1009846006727 PBP superfamily domain; Region: PBP_like_2; cl17296 1009846006728 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1009846006729 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1009846006730 active site 1009846006731 substrate binding site [chemical binding]; other site 1009846006732 metal binding site [ion binding]; metal-binding site 1009846006733 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1009846006734 dihydropteroate synthase; Region: DHPS; TIGR01496 1009846006735 substrate binding pocket [chemical binding]; other site 1009846006736 dimer interface [polypeptide binding]; other site 1009846006737 inhibitor binding site; inhibition site 1009846006738 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1009846006739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846006740 Walker A motif; other site 1009846006741 ATP binding site [chemical binding]; other site 1009846006742 Walker B motif; other site 1009846006743 arginine finger; other site 1009846006744 Peptidase family M41; Region: Peptidase_M41; pfam01434 1009846006745 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1009846006746 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1009846006747 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1009846006748 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 1009846006749 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1009846006750 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1009846006751 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1009846006752 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1009846006753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009846006754 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1009846006755 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1009846006756 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009846006757 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009846006758 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1009846006759 IMP binding site; other site 1009846006760 dimer interface [polypeptide binding]; other site 1009846006761 interdomain contacts; other site 1009846006762 partial ornithine binding site; other site 1009846006763 leucine export protein LeuE; Provisional; Region: PRK10958 1009846006764 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1009846006765 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1009846006766 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1009846006767 catalytic site [active] 1009846006768 subunit interface [polypeptide binding]; other site 1009846006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006770 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846006771 putative substrate translocation pore; other site 1009846006772 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1009846006773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846006774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846006775 catalytic residue [active] 1009846006776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1009846006777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846006778 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1009846006779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846006780 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1009846006781 RNA/DNA hybrid binding site [nucleotide binding]; other site 1009846006782 active site 1009846006783 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1009846006784 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1009846006785 active site 1009846006786 catalytic site [active] 1009846006787 substrate binding site [chemical binding]; other site 1009846006788 hypothetical protein; Provisional; Region: PRK02237 1009846006789 proline/glycine betaine transporter; Provisional; Region: PRK10642 1009846006790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006791 putative substrate translocation pore; other site 1009846006792 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846006793 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1009846006794 C-terminal domain interface [polypeptide binding]; other site 1009846006795 GSH binding site (G-site) [chemical binding]; other site 1009846006796 dimer interface [polypeptide binding]; other site 1009846006797 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1009846006798 dimer interface [polypeptide binding]; other site 1009846006799 N-terminal domain interface [polypeptide binding]; other site 1009846006800 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846006801 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846006802 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1009846006803 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1009846006804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846006805 active site 1009846006806 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1009846006807 putative active site [active] 1009846006808 catalytic site [active] 1009846006809 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1009846006810 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1009846006811 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 1009846006812 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 1009846006813 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1009846006814 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1009846006815 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1009846006816 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 1009846006817 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1009846006818 Coenzyme A transferase; Region: CoA_trans; cl17247 1009846006819 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1009846006820 Malonate transporter MadL subunit; Region: MadL; cl04273 1009846006821 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1009846006822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006823 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1009846006824 dimerization interface [polypeptide binding]; other site 1009846006825 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846006826 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1009846006827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846006828 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846006829 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1009846006830 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1009846006831 putative dimer interface [polypeptide binding]; other site 1009846006832 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1009846006833 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1009846006834 putative dimer interface [polypeptide binding]; other site 1009846006835 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1009846006836 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1009846006837 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1009846006838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846006840 dimerization interface [polypeptide binding]; other site 1009846006841 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1009846006842 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1009846006843 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1009846006844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846006845 catalytic residue [active] 1009846006846 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846006847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006848 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846006849 dimerization interface [polypeptide binding]; other site 1009846006850 substrate binding pocket [chemical binding]; other site 1009846006851 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846006853 putative substrate translocation pore; other site 1009846006854 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1009846006855 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1009846006856 active site 1009846006857 Zn binding site [ion binding]; other site 1009846006858 allantoate amidohydrolase; Reviewed; Region: PRK12893 1009846006859 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1009846006860 active site 1009846006861 metal binding site [ion binding]; metal-binding site 1009846006862 dimer interface [polypeptide binding]; other site 1009846006863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846006866 dimerization interface [polypeptide binding]; other site 1009846006867 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846006868 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846006869 trimer interface [polypeptide binding]; other site 1009846006870 eyelet of channel; other site 1009846006871 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1009846006872 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1009846006873 Na binding site [ion binding]; other site 1009846006874 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1009846006875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846006876 Coenzyme A binding pocket [chemical binding]; other site 1009846006877 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1009846006878 agmatinase; Region: agmatinase; TIGR01230 1009846006879 oligomer interface [polypeptide binding]; other site 1009846006880 putative active site [active] 1009846006881 Mn binding site [ion binding]; other site 1009846006882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846006885 dimerization interface [polypeptide binding]; other site 1009846006886 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1009846006887 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1009846006888 NAD binding site [chemical binding]; other site 1009846006889 active site 1009846006890 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846006891 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846006892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846006893 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1009846006894 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1009846006895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846006896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846006897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009846006898 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1009846006899 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846006900 E3 interaction surface; other site 1009846006901 lipoyl attachment site [posttranslational modification]; other site 1009846006902 e3 binding domain; Region: E3_binding; pfam02817 1009846006903 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1009846006904 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1009846006905 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1009846006906 alpha subunit interface [polypeptide binding]; other site 1009846006907 TPP binding site [chemical binding]; other site 1009846006908 heterodimer interface [polypeptide binding]; other site 1009846006909 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1009846006910 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1009846006911 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1009846006912 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1009846006913 tetramer interface [polypeptide binding]; other site 1009846006914 TPP-binding site [chemical binding]; other site 1009846006915 heterodimer interface [polypeptide binding]; other site 1009846006916 phosphorylation loop region [posttranslational modification] 1009846006917 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1009846006918 dimerization interface [polypeptide binding]; other site 1009846006919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846006920 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1009846006921 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1009846006922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846006923 substrate binding site [chemical binding]; other site 1009846006924 oxyanion hole (OAH) forming residues; other site 1009846006925 trimer interface [polypeptide binding]; other site 1009846006926 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1009846006927 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846006928 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846006929 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846006930 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846006931 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1009846006932 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846006933 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846006934 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846006935 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1009846006936 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1009846006937 NAD(P) binding site [chemical binding]; other site 1009846006938 substrate binding site [chemical binding]; other site 1009846006939 dimer interface [polypeptide binding]; other site 1009846006940 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1009846006941 Membrane transport protein; Region: Mem_trans; cl09117 1009846006942 short chain dehydrogenase; Provisional; Region: PRK09291 1009846006943 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1009846006944 NADP binding site [chemical binding]; other site 1009846006945 active site 1009846006946 steroid binding site; other site 1009846006947 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1009846006948 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1009846006949 NAD(P) binding site [chemical binding]; other site 1009846006950 substrate binding site [chemical binding]; other site 1009846006951 dimer interface [polypeptide binding]; other site 1009846006952 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1009846006953 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1009846006954 potential catalytic triad [active] 1009846006955 conserved cys residue [active] 1009846006956 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1009846006957 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846006958 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1009846006959 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1009846006960 Na binding site [ion binding]; other site 1009846006961 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1009846006962 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1009846006963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006964 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1009846006965 substrate binding pocket [chemical binding]; other site 1009846006966 dimerization interface [polypeptide binding]; other site 1009846006967 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1009846006968 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1009846006969 acyl-activating enzyme (AAE) consensus motif; other site 1009846006970 putative AMP binding site [chemical binding]; other site 1009846006971 putative active site [active] 1009846006972 putative CoA binding site [chemical binding]; other site 1009846006973 Putative cyclase; Region: Cyclase; pfam04199 1009846006974 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846006975 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846006976 trimer interface [polypeptide binding]; other site 1009846006977 eyelet of channel; other site 1009846006978 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846006979 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1009846006980 NAD(P) binding site [chemical binding]; other site 1009846006981 BON domain; Region: BON; pfam04972 1009846006982 transcriptional regulator; Provisional; Region: PRK10632 1009846006983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846006984 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846006985 putative effector binding pocket; other site 1009846006986 dimerization interface [polypeptide binding]; other site 1009846006987 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1009846006988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846006989 DNA binding residues [nucleotide binding] 1009846006990 dimerization interface [polypeptide binding]; other site 1009846006991 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1009846006992 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846006993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846006994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846006995 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846006996 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1009846006997 catalytic loop [active] 1009846006998 iron binding site [ion binding]; other site 1009846006999 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213 1009846007000 FAD binding pocket [chemical binding]; other site 1009846007001 FAD binding motif [chemical binding]; other site 1009846007002 phosphate binding motif [ion binding]; other site 1009846007003 beta-alpha-beta structure motif; other site 1009846007004 NAD binding pocket [chemical binding]; other site 1009846007005 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1009846007006 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846007007 Di-iron ligands [ion binding]; other site 1009846007008 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009846007009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846007010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846007011 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846007012 putative effector binding pocket; other site 1009846007013 dimerization interface [polypeptide binding]; other site 1009846007014 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1009846007015 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1009846007016 NADP binding site [chemical binding]; other site 1009846007017 dimer interface [polypeptide binding]; other site 1009846007018 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1009846007019 aspartate racemase; Region: asp_race; TIGR00035 1009846007020 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1009846007021 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1009846007022 catalytic triad [active] 1009846007023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846007024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846007025 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1009846007026 putative dimerization interface [polypeptide binding]; other site 1009846007027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846007028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846007029 DNA binding site [nucleotide binding] 1009846007030 domain linker motif; other site 1009846007031 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 1009846007032 putative dimerization interface [polypeptide binding]; other site 1009846007033 putative ligand binding site [chemical binding]; other site 1009846007034 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846007035 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846007036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007037 dimer interface [polypeptide binding]; other site 1009846007038 conserved gate region; other site 1009846007039 ABC-ATPase subunit interface; other site 1009846007040 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007042 dimer interface [polypeptide binding]; other site 1009846007043 conserved gate region; other site 1009846007044 putative PBP binding loops; other site 1009846007045 ABC-ATPase subunit interface; other site 1009846007046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846007047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846007048 Walker A/P-loop; other site 1009846007049 ATP binding site [chemical binding]; other site 1009846007050 Q-loop/lid; other site 1009846007051 ABC transporter signature motif; other site 1009846007052 Walker B; other site 1009846007053 D-loop; other site 1009846007054 H-loop/switch region; other site 1009846007055 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1009846007056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846007057 active site 1009846007058 metal binding site [ion binding]; metal-binding site 1009846007059 hexamer interface [polypeptide binding]; other site 1009846007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846007061 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1009846007062 EamA-like transporter family; Region: EamA; pfam00892 1009846007063 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1009846007064 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1009846007065 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1009846007066 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1009846007067 Moco binding site; other site 1009846007068 metal coordination site [ion binding]; other site 1009846007069 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1009846007070 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1009846007071 ThiC-associated domain; Region: ThiC-associated; pfam13667 1009846007072 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1009846007073 lipoprotein; Provisional; Region: PRK10540 1009846007074 EamA-like transporter family; Region: EamA; pfam00892 1009846007075 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846007076 EamA-like transporter family; Region: EamA; pfam00892 1009846007077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846007078 hypothetical protein; Provisional; Region: PRK09256 1009846007079 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1009846007080 AAA domain; Region: AAA_30; pfam13604 1009846007081 Family description; Region: UvrD_C_2; pfam13538 1009846007082 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1009846007083 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1009846007084 Family description; Region: UvrD_C_2; pfam13538 1009846007085 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1009846007086 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1009846007087 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1009846007088 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1009846007089 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846007090 putative proline-specific permease; Provisional; Region: proY; PRK10580 1009846007091 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846007092 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846007093 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1009846007094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007095 dimer interface [polypeptide binding]; other site 1009846007096 conserved gate region; other site 1009846007097 putative PBP binding loops; other site 1009846007098 ABC-ATPase subunit interface; other site 1009846007099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007100 dimer interface [polypeptide binding]; other site 1009846007101 conserved gate region; other site 1009846007102 putative PBP binding loops; other site 1009846007103 ABC-ATPase subunit interface; other site 1009846007104 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1009846007105 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1009846007106 Walker A/P-loop; other site 1009846007107 ATP binding site [chemical binding]; other site 1009846007108 Q-loop/lid; other site 1009846007109 ABC transporter signature motif; other site 1009846007110 Walker B; other site 1009846007111 D-loop; other site 1009846007112 H-loop/switch region; other site 1009846007113 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846007114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846007115 putative DNA binding site [nucleotide binding]; other site 1009846007116 putative Zn2+ binding site [ion binding]; other site 1009846007117 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846007118 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1009846007119 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1009846007120 NAD binding site [chemical binding]; other site 1009846007121 substrate binding site [chemical binding]; other site 1009846007122 putative active site [active] 1009846007123 Predicted transcriptional regulator [Transcription]; Region: COG1959 1009846007124 Transcriptional regulator; Region: Rrf2; pfam02082 1009846007125 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1009846007126 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1009846007127 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1009846007128 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1009846007129 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1009846007130 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1009846007131 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1009846007132 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1009846007133 Secretin and TonB N terminus short domain; Region: STN; smart00965 1009846007134 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1009846007135 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1009846007136 GspL periplasmic domain; Region: GspL_C; cl14909 1009846007137 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1009846007138 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1009846007139 Walker A motif; other site 1009846007140 ATP binding site [chemical binding]; other site 1009846007141 Walker B motif; other site 1009846007142 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1009846007143 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846007144 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846007145 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1009846007146 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1009846007147 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1009846007148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846007149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846007150 active site 1009846007151 phosphorylation site [posttranslational modification] 1009846007152 intermolecular recognition site; other site 1009846007153 dimerization interface [polypeptide binding]; other site 1009846007154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846007155 DNA binding residues [nucleotide binding] 1009846007156 dimerization interface [polypeptide binding]; other site 1009846007157 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1009846007158 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1009846007159 Cu(I) binding site [ion binding]; other site 1009846007160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846007161 PAS domain; Region: PAS_9; pfam13426 1009846007162 putative active site [active] 1009846007163 heme pocket [chemical binding]; other site 1009846007164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009846007165 Histidine kinase; Region: HisKA_3; pfam07730 1009846007166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846007167 ATP binding site [chemical binding]; other site 1009846007168 Mg2+ binding site [ion binding]; other site 1009846007169 G-X-G motif; other site 1009846007170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846007171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846007172 active site 1009846007173 phosphorylation site [posttranslational modification] 1009846007174 intermolecular recognition site; other site 1009846007175 dimerization interface [polypeptide binding]; other site 1009846007176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846007177 DNA binding residues [nucleotide binding] 1009846007178 dimerization interface [polypeptide binding]; other site 1009846007179 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846007180 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846007181 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846007182 catalytic residue [active] 1009846007183 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1009846007184 Cytochrome c; Region: Cytochrom_C; cl11414 1009846007185 Cytochrome c; Region: Cytochrom_C; cl11414 1009846007186 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1009846007187 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1009846007188 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1009846007189 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1009846007190 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1009846007191 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1009846007192 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1009846007193 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846007194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846007195 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846007196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846007197 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846007198 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846007199 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846007200 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1009846007201 Protein export membrane protein; Region: SecD_SecF; cl14618 1009846007202 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1009846007203 Protein export membrane protein; Region: SecD_SecF; cl14618 1009846007204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1009846007205 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846007206 active site 1009846007207 metal binding site [ion binding]; metal-binding site 1009846007208 NYN domain; Region: NYN; pfam01936 1009846007209 putative metal binding site [ion binding]; other site 1009846007210 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1009846007211 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1009846007212 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1009846007213 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1009846007214 NAD(P) binding site [chemical binding]; other site 1009846007215 putative active site [active] 1009846007216 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1009846007217 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1009846007218 catalytic triad [active] 1009846007219 PAS domain; Region: PAS_9; pfam13426 1009846007220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846007221 putative active site [active] 1009846007222 heme pocket [chemical binding]; other site 1009846007223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846007224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846007225 metal binding site [ion binding]; metal-binding site 1009846007226 active site 1009846007227 I-site; other site 1009846007228 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846007229 HDOD domain; Region: HDOD; pfam08668 1009846007230 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1009846007231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846007232 substrate binding pocket [chemical binding]; other site 1009846007233 membrane-bound complex binding site; other site 1009846007234 hinge residues; other site 1009846007235 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1009846007236 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1009846007237 putative active site [active] 1009846007238 Zn binding site [ion binding]; other site 1009846007239 succinylarginine dihydrolase; Provisional; Region: PRK13281 1009846007240 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1009846007241 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1009846007242 NAD(P) binding site [chemical binding]; other site 1009846007243 catalytic residues [active] 1009846007244 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1009846007245 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1009846007246 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1009846007247 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1009846007248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846007249 inhibitor-cofactor binding pocket; inhibition site 1009846007250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846007251 catalytic residue [active] 1009846007252 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846007253 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846007254 conserved cys residue [active] 1009846007255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846007256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846007257 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1009846007258 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846007259 Walker A/P-loop; other site 1009846007260 ATP binding site [chemical binding]; other site 1009846007261 Q-loop/lid; other site 1009846007262 ABC transporter signature motif; other site 1009846007263 Walker B; other site 1009846007264 D-loop; other site 1009846007265 H-loop/switch region; other site 1009846007266 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846007267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007268 dimer interface [polypeptide binding]; other site 1009846007269 conserved gate region; other site 1009846007270 putative PBP binding loops; other site 1009846007271 ABC-ATPase subunit interface; other site 1009846007272 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846007273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007274 dimer interface [polypeptide binding]; other site 1009846007275 conserved gate region; other site 1009846007276 putative PBP binding loops; other site 1009846007277 ABC-ATPase subunit interface; other site 1009846007278 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1009846007279 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1009846007280 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 1009846007281 putative active site [active] 1009846007282 YdjC motif; other site 1009846007283 Mg binding site [ion binding]; other site 1009846007284 putative homodimer interface [polypeptide binding]; other site 1009846007285 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1009846007286 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1009846007287 B12 binding site [chemical binding]; other site 1009846007288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846007289 FeS/SAM binding site; other site 1009846007290 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1009846007291 ligand binding site; other site 1009846007292 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1009846007293 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1009846007294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1009846007295 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1009846007296 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846007297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846007298 pyridoxamine kinase; Validated; Region: PRK05756 1009846007299 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1009846007300 dimer interface [polypeptide binding]; other site 1009846007301 pyridoxal binding site [chemical binding]; other site 1009846007302 ATP binding site [chemical binding]; other site 1009846007303 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1009846007304 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1009846007305 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846007306 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1009846007307 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846007308 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846007309 dimerization interface [polypeptide binding]; other site 1009846007310 ligand binding site [chemical binding]; other site 1009846007311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846007312 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1009846007313 DNA-binding site [nucleotide binding]; DNA binding site 1009846007314 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846007315 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1009846007316 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1009846007317 active site 1009846007318 tetramer interface [polypeptide binding]; other site 1009846007319 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 1009846007320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846007321 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1009846007322 putative ADP-binding pocket [chemical binding]; other site 1009846007323 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009846007324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846007325 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1009846007326 Walker A/P-loop; other site 1009846007327 ATP binding site [chemical binding]; other site 1009846007328 Q-loop/lid; other site 1009846007329 ABC transporter signature motif; other site 1009846007330 Walker B; other site 1009846007331 D-loop; other site 1009846007332 H-loop/switch region; other site 1009846007333 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1009846007334 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1009846007335 active site 1009846007336 homotetramer interface [polypeptide binding]; other site 1009846007337 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1009846007338 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1009846007339 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1009846007340 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846007341 Cu(I) binding site [ion binding]; other site 1009846007342 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1009846007343 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1009846007344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846007345 Pirin-related protein [General function prediction only]; Region: COG1741 1009846007346 Pirin; Region: Pirin; pfam02678 1009846007347 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1009846007348 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846007349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846007350 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1009846007351 putative effector binding pocket; other site 1009846007352 putative dimerization interface [polypeptide binding]; other site 1009846007353 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1009846007354 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1009846007355 active site 1009846007356 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1009846007357 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846007358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846007359 non-specific DNA binding site [nucleotide binding]; other site 1009846007360 salt bridge; other site 1009846007361 sequence-specific DNA binding site [nucleotide binding]; other site 1009846007362 Cupin domain; Region: Cupin_2; cl17218 1009846007363 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1009846007364 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1009846007365 PBP superfamily domain; Region: PBP_like_2; cl17296 1009846007366 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1009846007367 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1009846007368 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1009846007369 GIY-YIG motif/motif A; other site 1009846007370 active site 1009846007371 catalytic site [active] 1009846007372 putative DNA binding site [nucleotide binding]; other site 1009846007373 metal binding site [ion binding]; metal-binding site 1009846007374 UvrB/uvrC motif; Region: UVR; pfam02151 1009846007375 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1009846007376 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1009846007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1009846007378 elongation factor P; Validated; Region: PRK00529 1009846007379 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1009846007380 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1009846007381 RNA binding site [nucleotide binding]; other site 1009846007382 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1009846007383 RNA binding site [nucleotide binding]; other site 1009846007384 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846007385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846007386 active site 1009846007387 phosphorylation site [posttranslational modification] 1009846007388 intermolecular recognition site; other site 1009846007389 dimerization interface [polypeptide binding]; other site 1009846007390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846007391 Walker A motif; other site 1009846007392 ATP binding site [chemical binding]; other site 1009846007393 Walker B motif; other site 1009846007394 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846007395 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1009846007396 beta-hexosaminidase; Provisional; Region: PRK05337 1009846007397 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1009846007398 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1009846007399 active site 1009846007400 hydrophilic channel; other site 1009846007401 dimerization interface [polypeptide binding]; other site 1009846007402 catalytic residues [active] 1009846007403 active site lid [active] 1009846007404 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1009846007405 Recombination protein O N terminal; Region: RecO_N; pfam11967 1009846007406 Recombination protein O C terminal; Region: RecO_C; pfam02565 1009846007407 GTPase Era; Reviewed; Region: era; PRK00089 1009846007408 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1009846007409 G1 box; other site 1009846007410 GTP/Mg2+ binding site [chemical binding]; other site 1009846007411 Switch I region; other site 1009846007412 G2 box; other site 1009846007413 Switch II region; other site 1009846007414 G3 box; other site 1009846007415 G4 box; other site 1009846007416 G5 box; other site 1009846007417 KH domain; Region: KH_2; pfam07650 1009846007418 ribonuclease III; Reviewed; Region: PRK12372 1009846007419 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1009846007420 dimerization interface [polypeptide binding]; other site 1009846007421 active site 1009846007422 metal binding site [ion binding]; metal-binding site 1009846007423 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1009846007424 signal peptidase I; Provisional; Region: PRK10861 1009846007425 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1009846007426 Catalytic site [active] 1009846007427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1009846007428 GTP-binding protein LepA; Provisional; Region: PRK05433 1009846007429 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1009846007430 G1 box; other site 1009846007431 putative GEF interaction site [polypeptide binding]; other site 1009846007432 GTP/Mg2+ binding site [chemical binding]; other site 1009846007433 Switch I region; other site 1009846007434 G2 box; other site 1009846007435 G3 box; other site 1009846007436 Switch II region; other site 1009846007437 G4 box; other site 1009846007438 G5 box; other site 1009846007439 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1009846007440 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1009846007441 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1009846007442 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1009846007443 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1009846007444 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1009846007445 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846007446 protein binding site [polypeptide binding]; other site 1009846007447 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846007448 protein binding site [polypeptide binding]; other site 1009846007449 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1009846007450 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1009846007451 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1009846007452 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1009846007453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846007454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846007455 DNA binding residues [nucleotide binding] 1009846007456 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1009846007457 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1009846007458 dimer interface [polypeptide binding]; other site 1009846007459 active site 1009846007460 acyl carrier protein; Provisional; Region: acpP; PRK00982 1009846007461 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1009846007462 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1009846007463 NAD(P) binding site [chemical binding]; other site 1009846007464 homotetramer interface [polypeptide binding]; other site 1009846007465 homodimer interface [polypeptide binding]; other site 1009846007466 active site 1009846007467 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1009846007468 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1009846007469 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1009846007470 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1009846007471 dimer interface [polypeptide binding]; other site 1009846007472 active site 1009846007473 CoA binding pocket [chemical binding]; other site 1009846007474 putative phosphate acyltransferase; Provisional; Region: PRK05331 1009846007475 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1009846007476 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1009846007477 Maf-like protein; Region: Maf; pfam02545 1009846007478 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1009846007479 active site 1009846007480 dimer interface [polypeptide binding]; other site 1009846007481 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 1009846007482 putative SAM binding site [chemical binding]; other site 1009846007483 homodimer interface [polypeptide binding]; other site 1009846007484 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1009846007485 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1009846007486 tandem repeat interface [polypeptide binding]; other site 1009846007487 oligomer interface [polypeptide binding]; other site 1009846007488 active site residues [active] 1009846007489 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1009846007490 iron-sulfur cluster [ion binding]; other site 1009846007491 [2Fe-2S] cluster binding site [ion binding]; other site 1009846007492 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1009846007493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846007494 motif II; other site 1009846007495 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1009846007496 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1009846007497 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846007498 RNA binding surface [nucleotide binding]; other site 1009846007499 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1009846007500 active site 1009846007501 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1009846007502 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1009846007503 homodimer interface [polypeptide binding]; other site 1009846007504 oligonucleotide binding site [chemical binding]; other site 1009846007505 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1009846007506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846007507 FeS/SAM binding site; other site 1009846007508 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1009846007509 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1009846007510 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1009846007511 GTP binding site; other site 1009846007512 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1009846007513 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1009846007514 dimer interface [polypeptide binding]; other site 1009846007515 putative functional site; other site 1009846007516 putative MPT binding site; other site 1009846007517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009846007518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846007519 Coenzyme A binding pocket [chemical binding]; other site 1009846007520 RmuC family; Region: RmuC; pfam02646 1009846007521 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1009846007522 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1009846007523 dimerization interface [polypeptide binding]; other site 1009846007524 ligand binding site [chemical binding]; other site 1009846007525 NADP binding site [chemical binding]; other site 1009846007526 catalytic site [active] 1009846007527 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1009846007528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1009846007529 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1009846007530 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1009846007531 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1009846007532 active site 1009846007533 Ferredoxin [Energy production and conversion]; Region: COG1146 1009846007534 4Fe-4S binding domain; Region: Fer4; cl02805 1009846007535 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1009846007536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1009846007537 CreA protein; Region: CreA; pfam05981 1009846007538 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846007539 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846007540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846007541 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1009846007542 Predicted membrane protein [Function unknown]; Region: COG4392 1009846007543 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 1009846007544 S4 domain; Region: S4_2; pfam13275 1009846007545 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1009846007546 putative efflux protein, MATE family; Region: matE; TIGR00797 1009846007547 cation binding site [ion binding]; other site 1009846007548 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1009846007549 Class II fumarases; Region: Fumarase_classII; cd01362 1009846007550 active site 1009846007551 tetramer interface [polypeptide binding]; other site 1009846007552 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1009846007553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846007554 dimerization interface [polypeptide binding]; other site 1009846007555 putative DNA binding site [nucleotide binding]; other site 1009846007556 putative Zn2+ binding site [ion binding]; other site 1009846007557 FecR protein; Region: FecR; pfam04773 1009846007558 thymidylate synthase; Provisional; Region: thyA; PRK13821 1009846007559 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1009846007560 dimerization interface [polypeptide binding]; other site 1009846007561 active site 1009846007562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846007563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846007564 Walker A motif; other site 1009846007565 ATP binding site [chemical binding]; other site 1009846007566 Walker B motif; other site 1009846007567 arginine finger; other site 1009846007568 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1009846007569 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1009846007570 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1009846007571 folate binding site [chemical binding]; other site 1009846007572 NADP+ binding site [chemical binding]; other site 1009846007573 peptidase PmbA; Provisional; Region: PRK11040 1009846007574 hypothetical protein; Provisional; Region: PRK05255 1009846007575 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1009846007576 MPT binding site; other site 1009846007577 trimer interface [polypeptide binding]; other site 1009846007578 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1009846007579 catalytic site [active] 1009846007580 putative active site [active] 1009846007581 putative substrate binding site [chemical binding]; other site 1009846007582 dimer interface [polypeptide binding]; other site 1009846007583 Peptidase family M48; Region: Peptidase_M48; pfam01435 1009846007584 GTPase RsgA; Reviewed; Region: PRK00098 1009846007585 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1009846007586 RNA binding site [nucleotide binding]; other site 1009846007587 homodimer interface [polypeptide binding]; other site 1009846007588 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1009846007589 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1009846007590 GTP/Mg2+ binding site [chemical binding]; other site 1009846007591 G4 box; other site 1009846007592 G5 box; other site 1009846007593 G1 box; other site 1009846007594 Switch I region; other site 1009846007595 G2 box; other site 1009846007596 G3 box; other site 1009846007597 Switch II region; other site 1009846007598 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1009846007599 CobD/CbiB family protein; Provisional; Region: PRK07630 1009846007600 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1009846007601 putative active site [active] 1009846007602 putative CoA binding site [chemical binding]; other site 1009846007603 nudix motif; other site 1009846007604 metal binding site [ion binding]; metal-binding site 1009846007605 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1009846007606 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1009846007607 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 1009846007608 RimM N-terminal domain; Region: RimM; pfam01782 1009846007609 PRC-barrel domain; Region: PRC; pfam05239 1009846007610 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1009846007611 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1009846007612 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1009846007613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1009846007614 FeS/SAM binding site; other site 1009846007615 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846007616 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846007617 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1009846007618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846007619 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846007620 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1009846007621 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1009846007622 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1009846007623 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1009846007624 Ligand binding site [chemical binding]; other site 1009846007625 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1009846007626 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1009846007627 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1009846007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007629 dimer interface [polypeptide binding]; other site 1009846007630 conserved gate region; other site 1009846007631 ABC-ATPase subunit interface; other site 1009846007632 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1009846007633 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1009846007634 Walker A/P-loop; other site 1009846007635 ATP binding site [chemical binding]; other site 1009846007636 Q-loop/lid; other site 1009846007637 ABC transporter signature motif; other site 1009846007638 Walker B; other site 1009846007639 D-loop; other site 1009846007640 H-loop/switch region; other site 1009846007641 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1009846007642 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1009846007643 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846007644 Serine hydrolase; Region: Ser_hydrolase; cl17834 1009846007645 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1009846007646 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1009846007647 putative active site [active] 1009846007648 Zn binding site [ion binding]; other site 1009846007649 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1009846007650 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846007651 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846007652 cysteine synthase B; Region: cysM; TIGR01138 1009846007653 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1009846007654 dimer interface [polypeptide binding]; other site 1009846007655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846007656 catalytic residue [active] 1009846007657 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1009846007658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1009846007659 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1009846007660 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1009846007661 NADP binding site [chemical binding]; other site 1009846007662 homopentamer interface [polypeptide binding]; other site 1009846007663 substrate binding site [chemical binding]; other site 1009846007664 active site 1009846007665 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1009846007666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846007667 putative ribose interaction site [chemical binding]; other site 1009846007668 putative ADP binding site [chemical binding]; other site 1009846007669 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1009846007670 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1009846007671 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1009846007672 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1009846007673 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1009846007674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846007675 binding surface 1009846007676 TPR motif; other site 1009846007677 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1009846007678 IHF dimer interface [polypeptide binding]; other site 1009846007679 IHF - DNA interface [nucleotide binding]; other site 1009846007680 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1009846007681 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1009846007682 RNA binding site [nucleotide binding]; other site 1009846007683 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1009846007684 RNA binding site [nucleotide binding]; other site 1009846007685 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1009846007686 RNA binding site [nucleotide binding]; other site 1009846007687 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1009846007688 RNA binding site [nucleotide binding]; other site 1009846007689 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1009846007690 RNA binding site [nucleotide binding]; other site 1009846007691 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1009846007692 RNA binding site [nucleotide binding]; other site 1009846007693 cytidylate kinase; Provisional; Region: cmk; PRK00023 1009846007694 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1009846007695 CMP-binding site; other site 1009846007696 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 1009846007697 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1009846007698 hinge; other site 1009846007699 active site 1009846007700 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1009846007701 prephenate dehydrogenase; Validated; Region: PRK08507 1009846007702 Chorismate mutase type II; Region: CM_2; smart00830 1009846007703 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1009846007704 Prephenate dehydratase; Region: PDT; pfam00800 1009846007705 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1009846007706 putative L-Phe binding site [chemical binding]; other site 1009846007707 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1009846007708 homodimer interface [polypeptide binding]; other site 1009846007709 substrate-cofactor binding pocket; other site 1009846007710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846007711 catalytic residue [active] 1009846007712 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1009846007713 DNA gyrase subunit A; Validated; Region: PRK05560 1009846007714 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1009846007715 CAP-like domain; other site 1009846007716 active site 1009846007717 primary dimer interface [polypeptide binding]; other site 1009846007718 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007719 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1009846007724 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846007725 ligand binding site [chemical binding]; other site 1009846007726 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1009846007727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846007728 S-adenosylmethionine binding site [chemical binding]; other site 1009846007729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846007730 motif II; other site 1009846007731 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846007732 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1009846007733 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1009846007734 PBP superfamily domain; Region: PBP_like; pfam12727 1009846007735 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1009846007736 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009846007737 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1009846007738 putative dimer interface [polypeptide binding]; other site 1009846007739 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1009846007740 SLBB domain; Region: SLBB; pfam10531 1009846007741 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1009846007742 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1009846007743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846007744 catalytic loop [active] 1009846007745 iron binding site [ion binding]; other site 1009846007746 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1009846007747 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1009846007748 [4Fe-4S] binding site [ion binding]; other site 1009846007749 molybdopterin cofactor binding site; other site 1009846007750 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1009846007751 molybdopterin cofactor binding site; other site 1009846007752 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1009846007753 hypothetical protein; Provisional; Region: PRK06184 1009846007754 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846007755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846007756 TPR motif; other site 1009846007757 binding surface 1009846007758 TPR repeat; Region: TPR_11; pfam13414 1009846007759 TPR repeat; Region: TPR_11; pfam13414 1009846007760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846007761 binding surface 1009846007762 TPR motif; other site 1009846007763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846007764 TPR motif; other site 1009846007765 binding surface 1009846007766 TPR repeat; Region: TPR_11; pfam13414 1009846007767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846007768 TPR motif; other site 1009846007769 binding surface 1009846007770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846007771 citrate-proton symporter; Provisional; Region: PRK15075 1009846007772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846007773 putative substrate translocation pore; other site 1009846007774 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1009846007775 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1009846007776 Peptidase C26; Region: Peptidase_C26; pfam07722 1009846007777 catalytic triad [active] 1009846007778 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846007779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846007780 DNA-binding site [nucleotide binding]; DNA binding site 1009846007781 FCD domain; Region: FCD; pfam07729 1009846007782 amidase; Provisional; Region: PRK07056 1009846007783 Amidase; Region: Amidase; cl11426 1009846007784 disulfide bond formation protein B; Provisional; Region: PRK02110 1009846007785 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1009846007786 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1009846007787 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1009846007788 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1009846007789 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1009846007790 active site 1009846007791 purine riboside binding site [chemical binding]; other site 1009846007792 guanine deaminase; Provisional; Region: PRK09228 1009846007793 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1009846007794 active site 1009846007795 Predicted membrane protein [Function unknown]; Region: COG2119 1009846007796 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1009846007797 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1009846007798 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1009846007799 aminopeptidase N; Provisional; Region: pepN; PRK14015 1009846007800 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1009846007801 active site 1009846007802 Zn binding site [ion binding]; other site 1009846007803 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1009846007804 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1009846007805 AMP binding site [chemical binding]; other site 1009846007806 metal binding site [ion binding]; metal-binding site 1009846007807 active site 1009846007808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846007809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846007810 DNA binding residues [nucleotide binding] 1009846007811 dimerization interface [polypeptide binding]; other site 1009846007812 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1009846007813 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846007814 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009846007815 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846007816 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1009846007817 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846007818 N-terminal plug; other site 1009846007819 ligand-binding site [chemical binding]; other site 1009846007820 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1009846007821 chorismate mutase; Provisional; Region: PRK09269 1009846007822 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1009846007823 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1009846007824 active site 1009846007825 catalytic site [active] 1009846007826 substrate binding site [chemical binding]; other site 1009846007827 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1009846007828 GIY-YIG motif/motif A; other site 1009846007829 active site 1009846007830 catalytic site [active] 1009846007831 putative DNA binding site [nucleotide binding]; other site 1009846007832 metal binding site [ion binding]; metal-binding site 1009846007833 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846007834 DNA-binding site [nucleotide binding]; DNA binding site 1009846007835 RNA-binding motif; other site 1009846007836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1009846007837 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1009846007838 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1009846007839 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1009846007840 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1009846007841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009846007842 Zn2+ binding site [ion binding]; other site 1009846007843 Mg2+ binding site [ion binding]; other site 1009846007844 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1009846007845 synthetase active site [active] 1009846007846 NTP binding site [chemical binding]; other site 1009846007847 metal binding site [ion binding]; metal-binding site 1009846007848 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1009846007849 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1009846007850 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1009846007851 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1009846007852 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1009846007853 catalytic site [active] 1009846007854 G-X2-G-X-G-K; other site 1009846007855 hypothetical protein; Provisional; Region: PRK11820 1009846007856 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1009846007857 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1009846007858 ribonuclease PH; Reviewed; Region: rph; PRK00173 1009846007859 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1009846007860 hexamer interface [polypeptide binding]; other site 1009846007861 active site 1009846007862 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1009846007863 active site 1009846007864 dimerization interface [polypeptide binding]; other site 1009846007865 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 1009846007866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846007867 FeS/SAM binding site; other site 1009846007868 HemN C-terminal domain; Region: HemN_C; pfam06969 1009846007869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846007870 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846007871 putative substrate translocation pore; other site 1009846007872 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1009846007873 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1009846007874 putative active site [active] 1009846007875 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1009846007876 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1009846007877 putative ion selectivity filter; other site 1009846007878 putative pore gating glutamate residue; other site 1009846007879 putative H+/Cl- coupling transport residue; other site 1009846007880 cell division topological specificity factor MinE; Provisional; Region: PRK13989 1009846007881 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1009846007882 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1009846007883 Switch I; other site 1009846007884 Switch II; other site 1009846007885 septum formation inhibitor; Reviewed; Region: PRK01973 1009846007886 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1009846007887 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1009846007888 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846007889 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1009846007890 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846007891 Di-iron ligands [ion binding]; other site 1009846007892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846007893 dimerization interface [polypeptide binding]; other site 1009846007894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846007895 dimer interface [polypeptide binding]; other site 1009846007896 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1009846007897 putative CheW interface [polypeptide binding]; other site 1009846007898 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1009846007899 active site 1009846007900 seryl-tRNA synthetase; Provisional; Region: PRK05431 1009846007901 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1009846007902 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1009846007903 dimer interface [polypeptide binding]; other site 1009846007904 active site 1009846007905 motif 1; other site 1009846007906 motif 2; other site 1009846007907 motif 3; other site 1009846007908 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1009846007909 recombination factor protein RarA; Reviewed; Region: PRK13342 1009846007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846007911 Walker A motif; other site 1009846007912 ATP binding site [chemical binding]; other site 1009846007913 Walker B motif; other site 1009846007914 arginine finger; other site 1009846007915 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1009846007916 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1009846007917 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1009846007918 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1009846007919 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1009846007920 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1009846007921 thioredoxin reductase; Provisional; Region: PRK10262 1009846007922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846007923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846007924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1009846007925 Smr domain; Region: Smr; pfam01713 1009846007926 Predicted membrane protein [Function unknown]; Region: COG2860 1009846007927 UPF0126 domain; Region: UPF0126; pfam03458 1009846007928 UPF0126 domain; Region: UPF0126; pfam03458 1009846007929 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1009846007930 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1009846007931 Walker A/P-loop; other site 1009846007932 ATP binding site [chemical binding]; other site 1009846007933 Q-loop/lid; other site 1009846007934 ABC transporter signature motif; other site 1009846007935 Walker B; other site 1009846007936 D-loop; other site 1009846007937 H-loop/switch region; other site 1009846007938 TOBE domain; Region: TOBE_2; pfam08402 1009846007939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009846007940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007941 dimer interface [polypeptide binding]; other site 1009846007942 conserved gate region; other site 1009846007943 putative PBP binding loops; other site 1009846007944 ABC-ATPase subunit interface; other site 1009846007945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846007946 dimer interface [polypeptide binding]; other site 1009846007947 conserved gate region; other site 1009846007948 putative PBP binding loops; other site 1009846007949 ABC-ATPase subunit interface; other site 1009846007950 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009846007951 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009846007952 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1009846007953 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1009846007954 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1009846007955 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1009846007956 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1009846007957 putative active site [active] 1009846007958 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 1009846007959 glucokinase; Provisional; Region: glk; PRK00292 1009846007960 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846007961 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846007962 putative active site [active] 1009846007963 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1009846007964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846007965 putative substrate translocation pore; other site 1009846007966 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1009846007967 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846007968 inhibitor-cofactor binding pocket; inhibition site 1009846007969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846007970 catalytic residue [active] 1009846007971 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1009846007972 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1009846007973 catalytic motif [active] 1009846007974 Zn binding site [ion binding]; other site 1009846007975 RibD C-terminal domain; Region: RibD_C; cl17279 1009846007976 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1009846007977 Lumazine binding domain; Region: Lum_binding; pfam00677 1009846007978 Lumazine binding domain; Region: Lum_binding; pfam00677 1009846007979 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1009846007980 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1009846007981 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1009846007982 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1009846007983 dimerization interface [polypeptide binding]; other site 1009846007984 active site 1009846007985 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1009846007986 homopentamer interface [polypeptide binding]; other site 1009846007987 active site 1009846007988 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1009846007989 putative RNA binding site [nucleotide binding]; other site 1009846007990 aminotransferase; Validated; Region: PRK07337 1009846007991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846007992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846007993 homodimer interface [polypeptide binding]; other site 1009846007994 catalytic residue [active] 1009846007995 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846007996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846007997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846007998 catalytic residue [active] 1009846007999 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1009846008000 LysE type translocator; Region: LysE; cl00565 1009846008001 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1009846008002 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1009846008003 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1009846008004 YGGT family; Region: YGGT; pfam02325 1009846008005 YGGT family; Region: YGGT; pfam02325 1009846008006 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1009846008007 chromosome condensation membrane protein; Provisional; Region: PRK14196 1009846008008 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1009846008009 active site 1009846008010 catalytic triad [active] 1009846008011 calcium binding site [ion binding]; other site 1009846008012 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1009846008013 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1009846008014 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1009846008015 dimer interface [polypeptide binding]; other site 1009846008016 ADP-ribose binding site [chemical binding]; other site 1009846008017 active site 1009846008018 nudix motif; other site 1009846008019 metal binding site [ion binding]; metal-binding site 1009846008020 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1009846008021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846008022 DNA-binding site [nucleotide binding]; DNA binding site 1009846008023 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1009846008024 Chromate transporter; Region: Chromate_transp; pfam02417 1009846008025 Chromate transporter; Region: Chromate_transp; pfam02417 1009846008026 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1009846008027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846008028 substrate binding site [chemical binding]; other site 1009846008029 oxyanion hole (OAH) forming residues; other site 1009846008030 trimer interface [polypeptide binding]; other site 1009846008031 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1009846008032 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846008033 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846008034 benzoate transport; Region: 2A0115; TIGR00895 1009846008035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008036 putative substrate translocation pore; other site 1009846008037 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1009846008038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008039 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1009846008040 putative dimerization interface [polypeptide binding]; other site 1009846008041 LysE type translocator; Region: LysE; cl00565 1009846008042 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1009846008043 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846008044 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846008045 conserved cys residue [active] 1009846008046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846008047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846008048 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1009846008049 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1009846008050 nucleoside/Zn binding site; other site 1009846008051 dimer interface [polypeptide binding]; other site 1009846008052 catalytic motif [active] 1009846008053 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1009846008054 active site 1009846008055 homotetramer interface [polypeptide binding]; other site 1009846008056 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1009846008057 active site 1009846008058 homotetramer interface [polypeptide binding]; other site 1009846008059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008060 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846008061 putative substrate translocation pore; other site 1009846008062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008064 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 1009846008065 putative substrate binding pocket [chemical binding]; other site 1009846008066 putative dimerization interface [polypeptide binding]; other site 1009846008067 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1009846008068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846008069 S-adenosylmethionine binding site [chemical binding]; other site 1009846008070 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1009846008071 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1009846008072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846008073 FeS/SAM binding site; other site 1009846008074 HemN C-terminal domain; Region: HemN_C; pfam06969 1009846008075 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1009846008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846008077 S-adenosylmethionine binding site [chemical binding]; other site 1009846008078 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1009846008079 active site residue [active] 1009846008080 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1009846008081 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1009846008082 putative ligand binding site [chemical binding]; other site 1009846008083 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846008084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846008085 TM-ABC transporter signature motif; other site 1009846008086 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1009846008087 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846008088 TM-ABC transporter signature motif; other site 1009846008089 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1009846008090 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846008091 Walker A/P-loop; other site 1009846008092 ATP binding site [chemical binding]; other site 1009846008093 Q-loop/lid; other site 1009846008094 ABC transporter signature motif; other site 1009846008095 Walker B; other site 1009846008096 D-loop; other site 1009846008097 H-loop/switch region; other site 1009846008098 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1009846008099 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846008100 Walker A/P-loop; other site 1009846008101 ATP binding site [chemical binding]; other site 1009846008102 Q-loop/lid; other site 1009846008103 ABC transporter signature motif; other site 1009846008104 Walker B; other site 1009846008105 D-loop; other site 1009846008106 H-loop/switch region; other site 1009846008107 UreD urease accessory protein; Region: UreD; cl00530 1009846008108 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1009846008109 alpha-gamma subunit interface [polypeptide binding]; other site 1009846008110 beta-gamma subunit interface [polypeptide binding]; other site 1009846008111 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1009846008112 gamma-beta subunit interface [polypeptide binding]; other site 1009846008113 alpha-beta subunit interface [polypeptide binding]; other site 1009846008114 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1009846008115 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1009846008116 subunit interactions [polypeptide binding]; other site 1009846008117 active site 1009846008118 flap region; other site 1009846008119 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 1009846008120 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1009846008121 dimer interface [polypeptide binding]; other site 1009846008122 catalytic residues [active] 1009846008123 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1009846008124 UreF; Region: UreF; pfam01730 1009846008125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846008126 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1009846008127 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1009846008128 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846008129 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 1009846008130 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1009846008131 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1009846008132 putative active site [active] 1009846008133 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1009846008134 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1009846008135 active site 1009846008136 substrate binding site [chemical binding]; other site 1009846008137 metal binding site [ion binding]; metal-binding site 1009846008138 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1009846008139 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1009846008140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1009846008141 active site 1009846008142 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1009846008143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008144 putative ADP-binding pocket [chemical binding]; other site 1009846008145 UDP-glucose 4-epimerase; Region: PLN02240 1009846008146 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1009846008147 NAD binding site [chemical binding]; other site 1009846008148 homodimer interface [polypeptide binding]; other site 1009846008149 active site 1009846008150 substrate binding site [chemical binding]; other site 1009846008151 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1009846008152 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 1009846008153 Mg++ binding site [ion binding]; other site 1009846008154 putative catalytic motif [active] 1009846008155 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1009846008156 peptidase domain interface [polypeptide binding]; other site 1009846008157 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1009846008158 active site 1009846008159 catalytic triad [active] 1009846008160 calcium binding site [ion binding]; other site 1009846008161 D-mannose binding lectin; Region: B_lectin; pfam01453 1009846008162 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1009846008163 mannose binding site [chemical binding]; other site 1009846008164 dimerization interface [polypeptide binding]; other site 1009846008165 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1009846008166 dimerization interface [polypeptide binding]; other site 1009846008167 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1009846008168 mannose binding site [chemical binding]; other site 1009846008169 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1009846008170 CoA binding domain; Region: CoA_binding; cl17356 1009846008171 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1009846008172 NAD(P) binding site [chemical binding]; other site 1009846008173 homodimer interface [polypeptide binding]; other site 1009846008174 substrate binding site [chemical binding]; other site 1009846008175 active site 1009846008176 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1009846008177 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1009846008178 Mg++ binding site [ion binding]; other site 1009846008179 putative catalytic motif [active] 1009846008180 putative substrate binding site [chemical binding]; other site 1009846008181 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846008182 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1009846008183 putative NAD(P) binding site [chemical binding]; other site 1009846008184 active site 1009846008185 putative substrate binding site [chemical binding]; other site 1009846008186 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1009846008187 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1009846008188 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1009846008189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008190 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1009846008191 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846008193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846008194 NAD(P) binding site [chemical binding]; other site 1009846008195 active site 1009846008196 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1009846008197 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1009846008198 NADP-binding site; other site 1009846008199 homotetramer interface [polypeptide binding]; other site 1009846008200 substrate binding site [chemical binding]; other site 1009846008201 homodimer interface [polypeptide binding]; other site 1009846008202 active site 1009846008203 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1009846008204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008205 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1009846008206 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1009846008207 putative active site [active] 1009846008208 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1009846008209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008210 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1009846008211 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846008212 putative ribose interaction site [chemical binding]; other site 1009846008213 putative ADP binding site [chemical binding]; other site 1009846008214 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1009846008215 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1009846008216 active site 1009846008217 HIGH motif; other site 1009846008218 nucleotide binding site [chemical binding]; other site 1009846008219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1009846008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846008221 S-adenosylmethionine binding site [chemical binding]; other site 1009846008222 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1009846008223 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1009846008224 Walker A/P-loop; other site 1009846008225 ATP binding site [chemical binding]; other site 1009846008226 Q-loop/lid; other site 1009846008227 ABC transporter signature motif; other site 1009846008228 Walker B; other site 1009846008229 D-loop; other site 1009846008230 H-loop/switch region; other site 1009846008231 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1009846008232 putative carbohydrate binding site [chemical binding]; other site 1009846008233 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1009846008234 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1009846008235 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1009846008236 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1009846008237 Substrate binding site; other site 1009846008238 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1009846008239 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1009846008240 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1009846008241 NADP binding site [chemical binding]; other site 1009846008242 active site 1009846008243 putative substrate binding site [chemical binding]; other site 1009846008244 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1009846008245 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1009846008246 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1009846008247 substrate binding site; other site 1009846008248 tetramer interface; other site 1009846008249 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1009846008250 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1009846008251 NAD binding site [chemical binding]; other site 1009846008252 substrate binding site [chemical binding]; other site 1009846008253 homodimer interface [polypeptide binding]; other site 1009846008254 active site 1009846008255 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1009846008256 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1009846008257 active site 1009846008258 metal binding site [ion binding]; metal-binding site 1009846008259 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1009846008260 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1009846008261 putative acyl-acceptor binding pocket; other site 1009846008262 dihydroorotase; Provisional; Region: PRK07627 1009846008263 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1009846008264 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1009846008265 active site 1009846008266 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1009846008267 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1009846008268 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1009846008269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846008270 active site 1009846008271 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1009846008272 hypothetical protein; Validated; Region: PRK00228 1009846008273 Rubredoxin [Energy production and conversion]; Region: COG1773 1009846008274 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1009846008275 iron binding site [ion binding]; other site 1009846008276 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1009846008277 dimer interface [polypeptide binding]; other site 1009846008278 substrate binding site [chemical binding]; other site 1009846008279 ATP binding site [chemical binding]; other site 1009846008280 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1009846008281 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1009846008282 ring oligomerisation interface [polypeptide binding]; other site 1009846008283 ATP/Mg binding site [chemical binding]; other site 1009846008284 stacking interactions; other site 1009846008285 hinge regions; other site 1009846008286 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1009846008287 oligomerisation interface [polypeptide binding]; other site 1009846008288 mobile loop; other site 1009846008289 roof hairpin; other site 1009846008290 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1009846008291 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1009846008292 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1009846008293 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846008294 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846008295 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1009846008296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846008297 dimer interface [polypeptide binding]; other site 1009846008298 conserved gate region; other site 1009846008299 putative PBP binding loops; other site 1009846008300 ABC-ATPase subunit interface; other site 1009846008301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846008302 dimer interface [polypeptide binding]; other site 1009846008303 conserved gate region; other site 1009846008304 putative PBP binding loops; other site 1009846008305 ABC-ATPase subunit interface; other site 1009846008306 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1009846008307 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1009846008308 Walker A/P-loop; other site 1009846008309 ATP binding site [chemical binding]; other site 1009846008310 Q-loop/lid; other site 1009846008311 ABC transporter signature motif; other site 1009846008312 Walker B; other site 1009846008313 D-loop; other site 1009846008314 H-loop/switch region; other site 1009846008315 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1009846008316 putative hydrophobic ligand binding site [chemical binding]; other site 1009846008317 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1009846008318 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 1009846008319 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1009846008320 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1009846008321 RNA polymerase sigma factor; Provisional; Region: PRK12511 1009846008322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846008323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846008324 DNA binding residues [nucleotide binding] 1009846008325 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846008326 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846008327 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846008328 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846008329 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846008330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846008331 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846008332 substrate binding pocket [chemical binding]; other site 1009846008333 membrane-bound complex binding site; other site 1009846008334 hinge residues; other site 1009846008335 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1009846008336 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846008337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1009846008338 YheO-like PAS domain; Region: PAS_6; pfam08348 1009846008339 HTH domain; Region: HTH_22; pfam13309 1009846008340 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1009846008341 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1009846008342 catalytic residues [active] 1009846008343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846008345 putative substrate translocation pore; other site 1009846008346 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1009846008347 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1009846008348 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1009846008349 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 1009846008350 BON domain; Region: BON; pfam04972 1009846008351 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1009846008352 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1009846008353 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1009846008354 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1009846008355 putative catalytic residue [active] 1009846008356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846008359 dimerization interface [polypeptide binding]; other site 1009846008360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1009846008361 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1009846008362 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1009846008363 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1009846008364 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1009846008365 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846008366 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1009846008367 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846008368 catalytic loop [active] 1009846008369 iron binding site [ion binding]; other site 1009846008370 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1009846008371 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1009846008372 major facilitator superfamily transporter; Provisional; Region: PRK05122 1009846008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008374 EamA-like transporter family; Region: EamA; pfam00892 1009846008375 EamA-like transporter family; Region: EamA; pfam00892 1009846008376 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846008377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846008378 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1009846008379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846008380 catalytic residue [active] 1009846008381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008383 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846008384 putative effector binding pocket; other site 1009846008385 dimerization interface [polypeptide binding]; other site 1009846008386 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1009846008387 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1009846008388 putative ligand binding site [chemical binding]; other site 1009846008389 putative NAD binding site [chemical binding]; other site 1009846008390 catalytic site [active] 1009846008391 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1009846008392 putative FMN binding site [chemical binding]; other site 1009846008393 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846008394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008395 putative substrate translocation pore; other site 1009846008396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846008398 putative substrate translocation pore; other site 1009846008399 fumarylacetoacetase; Region: PLN02856 1009846008400 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1009846008401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846008402 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1009846008403 benzoate transport; Region: 2A0115; TIGR00895 1009846008404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008405 putative substrate translocation pore; other site 1009846008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008407 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 1009846008408 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1009846008409 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846008410 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846008411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1009846008412 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1009846008413 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846008414 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846008415 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846008416 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1009846008417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846008418 FAD binding site [chemical binding]; other site 1009846008419 substrate binding pocket [chemical binding]; other site 1009846008420 catalytic base [active] 1009846008421 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1009846008422 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1009846008423 dimer interface [polypeptide binding]; other site 1009846008424 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1009846008425 catalytic triad [active] 1009846008426 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1009846008427 Predicted membrane protein [Function unknown]; Region: COG5393 1009846008428 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1009846008429 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1009846008430 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1009846008431 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1009846008432 Type II transport protein GspH; Region: GspH; pfam12019 1009846008433 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1009846008434 ATP cone domain; Region: ATP-cone; pfam03477 1009846008435 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1009846008436 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1009846008437 dimer interface [polypeptide binding]; other site 1009846008438 active site 1009846008439 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1009846008440 folate binding site [chemical binding]; other site 1009846008441 malonic semialdehyde reductase; Provisional; Region: PRK10538 1009846008442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846008443 NAD(P) binding site [chemical binding]; other site 1009846008444 active site 1009846008445 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1009846008446 active site 1009846008447 TolQ protein; Region: tolQ; TIGR02796 1009846008448 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1009846008449 TolR protein; Region: tolR; TIGR02801 1009846008450 TolA protein; Region: tolA_full; TIGR02794 1009846008451 TolA protein; Region: tolA_full; TIGR02794 1009846008452 TonB C terminal; Region: TonB_2; pfam13103 1009846008453 translocation protein TolB; Provisional; Region: tolB; PRK02889 1009846008454 TolB amino-terminal domain; Region: TolB_N; pfam04052 1009846008455 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1009846008456 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1009846008457 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1009846008458 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846008459 ligand binding site [chemical binding]; other site 1009846008460 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1009846008461 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1009846008462 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1009846008463 Cupin; Region: Cupin_6; pfam12852 1009846008464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846008465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846008466 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846008467 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1009846008468 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1009846008469 putative active site [active] 1009846008470 putative dimer interface [polypeptide binding]; other site 1009846008471 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846008472 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1009846008473 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1009846008474 substrate-cofactor binding pocket; other site 1009846008475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846008476 catalytic residue [active] 1009846008477 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 1009846008478 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1009846008479 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1009846008480 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1009846008481 active site 1009846008482 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1009846008483 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1009846008484 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1009846008485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846008486 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1009846008487 Enoylreductase; Region: PKS_ER; smart00829 1009846008488 NAD(P) binding site [chemical binding]; other site 1009846008489 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1009846008490 KR domain; Region: KR; pfam08659 1009846008491 putative NADP binding site [chemical binding]; other site 1009846008492 active site 1009846008493 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1009846008494 Sulfatase; Region: Sulfatase; pfam00884 1009846008495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846008496 NAD(P) binding site [chemical binding]; other site 1009846008497 active site 1009846008498 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1009846008499 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1009846008500 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1009846008501 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1009846008502 oxyanion hole [active] 1009846008503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1009846008504 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1009846008505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846008506 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846008507 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1009846008508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846008509 putative homodimer interface [polypeptide binding]; other site 1009846008510 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 1009846008511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1009846008512 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1009846008513 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1009846008514 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846008515 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1009846008516 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1009846008517 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1009846008518 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1009846008519 active site 1009846008520 homodimer interface [polypeptide binding]; other site 1009846008521 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1009846008522 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1009846008523 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1009846008524 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1009846008525 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1009846008526 Walker A/P-loop; other site 1009846008527 ATP binding site [chemical binding]; other site 1009846008528 Q-loop/lid; other site 1009846008529 ABC transporter signature motif; other site 1009846008530 Walker B; other site 1009846008531 D-loop; other site 1009846008532 H-loop/switch region; other site 1009846008533 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1009846008534 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009846008535 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846008536 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846008537 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1009846008538 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1009846008539 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1009846008540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846008541 ATP binding site [chemical binding]; other site 1009846008542 Mg2+ binding site [ion binding]; other site 1009846008543 G-X-G motif; other site 1009846008544 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1009846008545 ATP binding site [chemical binding]; other site 1009846008546 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1009846008547 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1009846008548 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1009846008549 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1009846008550 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1009846008551 dimerization interface [polypeptide binding]; other site 1009846008552 putative ATP binding site [chemical binding]; other site 1009846008553 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 1009846008554 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1009846008555 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1009846008556 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1009846008557 poly(A) polymerase; Region: pcnB; TIGR01942 1009846008558 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1009846008559 active site 1009846008560 NTP binding site [chemical binding]; other site 1009846008561 metal binding triad [ion binding]; metal-binding site 1009846008562 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1009846008563 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1009846008564 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1009846008565 catalytic center binding site [active] 1009846008566 ATP binding site [chemical binding]; other site 1009846008567 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1009846008568 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1009846008569 Substrate-binding site [chemical binding]; other site 1009846008570 Substrate specificity [chemical binding]; other site 1009846008571 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1009846008572 oligomerization interface [polypeptide binding]; other site 1009846008573 active site 1009846008574 metal binding site [ion binding]; metal-binding site 1009846008575 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1009846008576 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1009846008577 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1009846008578 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1009846008579 substrate-cofactor binding pocket; other site 1009846008580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846008581 catalytic residue [active] 1009846008582 chaperone protein DnaJ; Provisional; Region: PRK10767 1009846008583 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1009846008584 HSP70 interaction site [polypeptide binding]; other site 1009846008585 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1009846008586 Zn binding sites [ion binding]; other site 1009846008587 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1009846008588 dimer interface [polypeptide binding]; other site 1009846008589 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1009846008590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1009846008591 nucleotide binding site [chemical binding]; other site 1009846008592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009846008593 catalytic residues [active] 1009846008594 GrpE; Region: GrpE; pfam01025 1009846008595 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1009846008596 dimer interface [polypeptide binding]; other site 1009846008597 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1009846008598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846008599 RNA binding surface [nucleotide binding]; other site 1009846008600 ferrochelatase; Reviewed; Region: hemH; PRK00035 1009846008601 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1009846008602 C-terminal domain interface [polypeptide binding]; other site 1009846008603 active site 1009846008604 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1009846008605 active site 1009846008606 N-terminal domain interface [polypeptide binding]; other site 1009846008607 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1009846008608 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1009846008609 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 1009846008610 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1009846008611 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1009846008612 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1009846008613 Walker A/P-loop; other site 1009846008614 ATP binding site [chemical binding]; other site 1009846008615 Q-loop/lid; other site 1009846008616 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1009846008617 ABC transporter signature motif; other site 1009846008618 Walker B; other site 1009846008619 D-loop; other site 1009846008620 H-loop/switch region; other site 1009846008621 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1009846008622 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1009846008623 metal binding triad; other site 1009846008624 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1009846008625 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1009846008626 metal binding triad; other site 1009846008627 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1009846008628 TIGR02099 family protein; Region: TIGR02099 1009846008629 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1009846008630 nitrilase; Region: PLN02798 1009846008631 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1009846008632 putative active site [active] 1009846008633 catalytic triad [active] 1009846008634 dimer interface [polypeptide binding]; other site 1009846008635 protease TldD; Provisional; Region: tldD; PRK10735 1009846008636 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1009846008637 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1009846008638 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1009846008639 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1009846008640 putative active site [active] 1009846008641 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1009846008642 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1009846008643 heme-binding site [chemical binding]; other site 1009846008644 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1009846008645 FAD binding pocket [chemical binding]; other site 1009846008646 FAD binding motif [chemical binding]; other site 1009846008647 phosphate binding motif [ion binding]; other site 1009846008648 beta-alpha-beta structure motif; other site 1009846008649 NAD binding pocket [chemical binding]; other site 1009846008650 Heme binding pocket [chemical binding]; other site 1009846008651 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1009846008652 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1009846008653 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846008654 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1009846008655 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846008656 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1009846008657 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846008658 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1009846008659 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1009846008660 Cysteine-rich domain; Region: CCG; pfam02754 1009846008661 Cysteine-rich domain; Region: CCG; pfam02754 1009846008662 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1009846008663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1009846008664 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1009846008665 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1009846008666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846008667 catalytic residue [active] 1009846008668 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1009846008669 pyrroline-5-carboxylate reductase; Region: PLN02688 1009846008670 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1009846008671 UbiA prenyltransferase family; Region: UbiA; pfam01040 1009846008672 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1009846008673 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1009846008674 dimer interface [polypeptide binding]; other site 1009846008675 active site 1009846008676 heme binding site [chemical binding]; other site 1009846008677 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1009846008678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008680 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1009846008681 dimerization interface [polypeptide binding]; other site 1009846008682 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1009846008683 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1009846008684 ssDNA binding site; other site 1009846008685 generic binding surface II; other site 1009846008686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846008687 ATP binding site [chemical binding]; other site 1009846008688 putative Mg++ binding site [ion binding]; other site 1009846008689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846008690 nucleotide binding region [chemical binding]; other site 1009846008691 ATP-binding site [chemical binding]; other site 1009846008692 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1009846008693 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1009846008694 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1009846008695 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1009846008696 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1009846008697 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1009846008698 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1009846008699 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1009846008700 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1009846008701 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1009846008702 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1009846008703 Protein export membrane protein; Region: SecD_SecF; pfam02355 1009846008704 citrate-proton symporter; Provisional; Region: PRK15075 1009846008705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008706 putative substrate translocation pore; other site 1009846008707 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1009846008708 YceI-like domain; Region: YceI; smart00867 1009846008709 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1009846008710 Paraquat-inducible protein A; Region: PqiA; pfam04403 1009846008711 Paraquat-inducible protein A; Region: PqiA; pfam04403 1009846008712 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1009846008713 mce related protein; Region: MCE; pfam02470 1009846008714 mce related protein; Region: MCE; pfam02470 1009846008715 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1009846008716 Site-specific recombinase; Region: SpecificRecomb; pfam10136 1009846008717 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1009846008718 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1009846008719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1009846008720 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1009846008721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846008722 Predicted transcriptional regulator [Transcription]; Region: COG2378 1009846008723 HTH domain; Region: HTH_11; pfam08279 1009846008724 WYL domain; Region: WYL; pfam13280 1009846008725 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1009846008726 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1009846008727 putative active site [active] 1009846008728 catalytic triad [active] 1009846008729 putative dimer interface [polypeptide binding]; other site 1009846008730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008732 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1009846008733 putative substrate binding pocket [chemical binding]; other site 1009846008734 putative dimerization interface [polypeptide binding]; other site 1009846008735 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1009846008736 nudix motif; other site 1009846008737 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1009846008738 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1009846008739 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1009846008740 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1009846008741 active site 1009846008742 FMN binding site [chemical binding]; other site 1009846008743 substrate binding site [chemical binding]; other site 1009846008744 3Fe-4S cluster binding site [ion binding]; other site 1009846008745 putative glutathione S-transferase; Provisional; Region: PRK10357 1009846008746 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1009846008747 putative C-terminal domain interface [polypeptide binding]; other site 1009846008748 putative GSH binding site (G-site) [chemical binding]; other site 1009846008749 putative dimer interface [polypeptide binding]; other site 1009846008750 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1009846008751 dimer interface [polypeptide binding]; other site 1009846008752 N-terminal domain interface [polypeptide binding]; other site 1009846008753 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846008754 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1009846008755 proline aminopeptidase P II; Provisional; Region: PRK10879 1009846008756 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1009846008757 active site 1009846008758 hypothetical protein; Provisional; Region: PRK06996 1009846008759 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846008760 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1009846008761 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1009846008762 FMN binding site [chemical binding]; other site 1009846008763 active site 1009846008764 catalytic residues [active] 1009846008765 substrate binding site [chemical binding]; other site 1009846008766 DNA-binding protein Fis; Provisional; Region: PRK01905 1009846008767 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1009846008768 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1009846008769 purine monophosphate binding site [chemical binding]; other site 1009846008770 dimer interface [polypeptide binding]; other site 1009846008771 putative catalytic residues [active] 1009846008772 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1009846008773 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1009846008774 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1009846008775 active site 1009846008776 putative DNA-binding cleft [nucleotide binding]; other site 1009846008777 dimer interface [polypeptide binding]; other site 1009846008778 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1009846008779 RuvA N terminal domain; Region: RuvA_N; pfam01330 1009846008780 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1009846008781 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1009846008782 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1009846008783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846008784 Walker A motif; other site 1009846008785 ATP binding site [chemical binding]; other site 1009846008786 Walker B motif; other site 1009846008787 arginine finger; other site 1009846008788 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1009846008789 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1009846008790 Putative ParB-like nuclease; Region: ParBc_2; cl17538 1009846008791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009846008792 catalytic core [active] 1009846008793 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1009846008794 putative active site [active] 1009846008795 dimerization interface [polypeptide binding]; other site 1009846008796 putative tRNAtyr binding site [nucleotide binding]; other site 1009846008797 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1009846008798 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1009846008799 active site 1009846008800 HIGH motif; other site 1009846008801 dimer interface [polypeptide binding]; other site 1009846008802 KMSKS motif; other site 1009846008803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846008804 RNA binding surface [nucleotide binding]; other site 1009846008805 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1009846008806 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1009846008807 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1009846008808 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1009846008809 23S rRNA interface [nucleotide binding]; other site 1009846008810 L3 interface [polypeptide binding]; other site 1009846008811 OsmC-like protein; Region: OsmC; cl00767 1009846008812 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 1009846008813 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1009846008814 active site 1009846008815 substrate binding pocket [chemical binding]; other site 1009846008816 dimer interface [polypeptide binding]; other site 1009846008817 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1009846008818 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1009846008819 putative dimer interface [polypeptide binding]; other site 1009846008820 putative active site [active] 1009846008821 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846008822 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846008823 Walker A/P-loop; other site 1009846008824 ATP binding site [chemical binding]; other site 1009846008825 Q-loop/lid; other site 1009846008826 ABC transporter signature motif; other site 1009846008827 Walker B; other site 1009846008828 D-loop; other site 1009846008829 H-loop/switch region; other site 1009846008830 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846008831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846008832 dimer interface [polypeptide binding]; other site 1009846008833 conserved gate region; other site 1009846008834 putative PBP binding loops; other site 1009846008835 ABC-ATPase subunit interface; other site 1009846008836 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846008837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846008838 dimer interface [polypeptide binding]; other site 1009846008839 conserved gate region; other site 1009846008840 putative PBP binding loops; other site 1009846008841 ABC-ATPase subunit interface; other site 1009846008842 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1009846008843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846008844 substrate binding pocket [chemical binding]; other site 1009846008845 membrane-bound complex binding site; other site 1009846008846 hinge residues; other site 1009846008847 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1009846008848 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1009846008849 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1009846008850 NAD(P) binding site [chemical binding]; other site 1009846008851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846008852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846008854 dimerization interface [polypeptide binding]; other site 1009846008855 adenylosuccinate lyase; Provisional; Region: PRK09285 1009846008856 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1009846008857 tetramer interface [polypeptide binding]; other site 1009846008858 active site 1009846008859 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846008860 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846008861 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1009846008862 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1009846008863 ATP-binding site [chemical binding]; other site 1009846008864 Gluconate-6-phosphate binding site [chemical binding]; other site 1009846008865 Shikimate kinase; Region: SKI; pfam01202 1009846008866 GntP family permease; Region: GntP_permease; pfam02447 1009846008867 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1009846008868 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1009846008869 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1009846008870 active site 1009846008871 intersubunit interface [polypeptide binding]; other site 1009846008872 catalytic residue [active] 1009846008873 phosphogluconate dehydratase; Validated; Region: PRK09054 1009846008874 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1009846008875 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846008876 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846008877 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846008878 putative active site [active] 1009846008879 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1009846008880 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1009846008881 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1009846008882 putative catalytic cysteine [active] 1009846008883 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1009846008884 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1009846008885 Lipopolysaccharide-assembly; Region: LptE; cl01125 1009846008886 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1009846008887 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1009846008888 HIGH motif; other site 1009846008889 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1009846008890 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009846008891 active site 1009846008892 KMSKS motif; other site 1009846008893 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1009846008894 tRNA binding surface [nucleotide binding]; other site 1009846008895 TolR protein; Region: tolR; TIGR02801 1009846008896 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1009846008897 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1009846008898 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1009846008899 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1009846008900 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1009846008901 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1009846008902 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1009846008903 ferric uptake regulator; Provisional; Region: fur; PRK09462 1009846008904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1009846008905 metal binding site 2 [ion binding]; metal-binding site 1009846008906 putative DNA binding helix; other site 1009846008907 metal binding site 1 [ion binding]; metal-binding site 1009846008908 dimer interface [polypeptide binding]; other site 1009846008909 structural Zn2+ binding site [ion binding]; other site 1009846008910 ureidoglycolate hydrolase; Provisional; Region: PRK13395 1009846008911 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1009846008912 allantoicase; Provisional; Region: PRK13257 1009846008913 Allantoicase repeat; Region: Allantoicase; pfam03561 1009846008914 Allantoicase repeat; Region: Allantoicase; pfam03561 1009846008915 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1009846008916 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846008917 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846008918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846008919 DNA-binding site [nucleotide binding]; DNA binding site 1009846008920 FCD domain; Region: FCD; pfam07729 1009846008921 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1009846008922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008923 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1009846008924 dimerization interface [polypeptide binding]; other site 1009846008925 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846008926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008927 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1009846008928 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1009846008929 putative NAD(P) binding site [chemical binding]; other site 1009846008930 catalytic Zn binding site [ion binding]; other site 1009846008931 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1009846008932 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1009846008933 putative ligand binding site [chemical binding]; other site 1009846008934 NAD binding site [chemical binding]; other site 1009846008935 catalytic site [active] 1009846008936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846008937 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846008938 putative substrate translocation pore; other site 1009846008939 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1009846008940 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1009846008941 NADP binding site [chemical binding]; other site 1009846008942 homodimer interface [polypeptide binding]; other site 1009846008943 active site 1009846008944 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846008945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846008946 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846008947 dimerization interface [polypeptide binding]; other site 1009846008948 substrate binding pocket [chemical binding]; other site 1009846008949 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1009846008950 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1009846008951 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1009846008952 transketolase; Reviewed; Region: PRK12753 1009846008953 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1009846008954 TPP-binding site [chemical binding]; other site 1009846008955 dimer interface [polypeptide binding]; other site 1009846008956 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1009846008957 PYR/PP interface [polypeptide binding]; other site 1009846008958 dimer interface [polypeptide binding]; other site 1009846008959 TPP binding site [chemical binding]; other site 1009846008960 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1009846008961 spermidine synthase; Provisional; Region: PRK00811 1009846008962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846008963 S-adenosylmethionine binding site [chemical binding]; other site 1009846008964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1009846008965 putative dimer interface [polypeptide binding]; other site 1009846008966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846008967 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1009846008968 RNA methyltransferase, RsmE family; Region: TIGR00046 1009846008969 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1009846008970 putative RNAase interaction site [polypeptide binding]; other site 1009846008971 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1009846008972 active site 1009846008973 barstar interaction site; other site 1009846008974 malic enzyme; Reviewed; Region: PRK12862 1009846008975 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1009846008976 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1009846008977 putative NAD(P) binding site [chemical binding]; other site 1009846008978 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1009846008979 thiamine monophosphate kinase; Provisional; Region: PRK05731 1009846008980 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1009846008981 ATP binding site [chemical binding]; other site 1009846008982 dimerization interface [polypeptide binding]; other site 1009846008983 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1009846008984 tetramer interfaces [polypeptide binding]; other site 1009846008985 binuclear metal-binding site [ion binding]; other site 1009846008986 Competence-damaged protein; Region: CinA; pfam02464 1009846008987 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1009846008988 active site 1009846008989 dimer interface [polypeptide binding]; other site 1009846008990 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1009846008991 active site 1009846008992 catalytic residues [active] 1009846008993 short chain dehydrogenase; Provisional; Region: PRK12939 1009846008994 classical (c) SDRs; Region: SDR_c; cd05233 1009846008995 NAD(P) binding site [chemical binding]; other site 1009846008996 active site 1009846008997 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846008998 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846008999 TM-ABC transporter signature motif; other site 1009846009000 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1009846009001 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846009002 Walker A/P-loop; other site 1009846009003 ATP binding site [chemical binding]; other site 1009846009004 Q-loop/lid; other site 1009846009005 ABC transporter signature motif; other site 1009846009006 Walker B; other site 1009846009007 D-loop; other site 1009846009008 H-loop/switch region; other site 1009846009009 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846009010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1009846009011 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1009846009012 ligand binding site [chemical binding]; other site 1009846009013 short chain dehydrogenase; Provisional; Region: PRK07063 1009846009014 classical (c) SDRs; Region: SDR_c; cd05233 1009846009015 NAD(P) binding site [chemical binding]; other site 1009846009016 active site 1009846009017 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1009846009018 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1009846009019 active site 1009846009020 intersubunit interface [polypeptide binding]; other site 1009846009021 catalytic residue [active] 1009846009022 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1009846009023 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1009846009024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846009025 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846009026 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846009027 EF-hand domain pair; Region: EF_hand_5; pfam13499 1009846009028 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1009846009029 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1009846009030 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1009846009031 Transglycosylase; Region: Transgly; cl17702 1009846009032 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1009846009033 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1009846009034 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1009846009035 shikimate binding site; other site 1009846009036 NAD(P) binding site [chemical binding]; other site 1009846009037 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1009846009038 RNB domain; Region: RNB; pfam00773 1009846009039 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1009846009040 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1009846009041 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1009846009042 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009846009043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846009044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846009045 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1009846009046 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846009047 catalytic residues [active] 1009846009048 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1009846009049 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1009846009050 active site 1009846009051 trimer interface [polypeptide binding]; other site 1009846009052 dimer interface [polypeptide binding]; other site 1009846009053 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1009846009054 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1009846009055 carboxyltransferase (CT) interaction site; other site 1009846009056 biotinylation site [posttranslational modification]; other site 1009846009057 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1009846009058 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009846009059 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009846009060 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1009846009061 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1009846009062 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846009063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846009064 S-adenosylmethionine binding site [chemical binding]; other site 1009846009065 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1009846009066 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1009846009067 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1009846009068 dimer interface [polypeptide binding]; other site 1009846009069 catalytic triad [active] 1009846009070 peroxidatic and resolving cysteines [active] 1009846009071 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1009846009072 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1009846009073 substrate binding site [chemical binding]; other site 1009846009074 ATP binding site [chemical binding]; other site 1009846009075 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1009846009076 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1009846009077 dimer interface [polypeptide binding]; other site 1009846009078 putative radical transfer pathway; other site 1009846009079 diiron center [ion binding]; other site 1009846009080 tyrosyl radical; other site 1009846009081 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1009846009082 ATP cone domain; Region: ATP-cone; pfam03477 1009846009083 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1009846009084 active site 1009846009085 dimer interface [polypeptide binding]; other site 1009846009086 catalytic residues [active] 1009846009087 effector binding site; other site 1009846009088 R2 peptide binding site; other site 1009846009089 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1009846009090 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1009846009091 amidase catalytic site [active] 1009846009092 Zn binding residues [ion binding]; other site 1009846009093 substrate binding site [chemical binding]; other site 1009846009094 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1009846009095 signal recognition particle protein; Provisional; Region: PRK10867 1009846009096 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1009846009097 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1009846009098 P loop; other site 1009846009099 GTP binding site [chemical binding]; other site 1009846009100 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1009846009101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846009102 active site 1009846009103 MarC family integral membrane protein; Region: MarC; cl00919 1009846009104 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1009846009105 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1009846009106 dimer interface [polypeptide binding]; other site 1009846009107 motif 1; other site 1009846009108 active site 1009846009109 motif 2; other site 1009846009110 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1009846009111 putative deacylase active site [active] 1009846009112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1009846009113 active site 1009846009114 motif 3; other site 1009846009115 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1009846009116 anticodon binding site; other site 1009846009117 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1009846009118 putative active site [active] 1009846009119 Ap4A binding site [chemical binding]; other site 1009846009120 nudix motif; other site 1009846009121 putative metal binding site [ion binding]; other site 1009846009122 CNP1-like family; Region: CNP1; pfam08750 1009846009123 gamma-glutamyl kinase; Provisional; Region: PRK05429 1009846009124 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1009846009125 nucleotide binding site [chemical binding]; other site 1009846009126 homotetrameric interface [polypeptide binding]; other site 1009846009127 putative phosphate binding site [ion binding]; other site 1009846009128 putative allosteric binding site; other site 1009846009129 PUA domain; Region: PUA; pfam01472 1009846009130 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1009846009131 GTP1/OBG; Region: GTP1_OBG; pfam01018 1009846009132 Obg GTPase; Region: Obg; cd01898 1009846009133 G1 box; other site 1009846009134 GTP/Mg2+ binding site [chemical binding]; other site 1009846009135 Switch I region; other site 1009846009136 G2 box; other site 1009846009137 G3 box; other site 1009846009138 Switch II region; other site 1009846009139 G4 box; other site 1009846009140 G5 box; other site 1009846009141 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1009846009142 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1009846009143 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1009846009144 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1009846009145 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1009846009146 substrate binding pocket [chemical binding]; other site 1009846009147 chain length determination region; other site 1009846009148 substrate-Mg2+ binding site; other site 1009846009149 catalytic residues [active] 1009846009150 aspartate-rich region 1; other site 1009846009151 active site lid residues [active] 1009846009152 aspartate-rich region 2; other site 1009846009153 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1009846009154 Domain of unknown function DUF21; Region: DUF21; pfam01595 1009846009155 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1009846009156 Transporter associated domain; Region: CorC_HlyC; smart01091 1009846009157 Type II/IV secretion system protein; Region: T2SE; pfam00437 1009846009158 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1009846009159 Walker A motif; other site 1009846009160 ATP binding site [chemical binding]; other site 1009846009161 Walker B motif; other site 1009846009162 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1009846009163 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846009164 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846009165 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1009846009166 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1009846009167 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1009846009168 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1009846009169 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1009846009170 CoA-binding site [chemical binding]; other site 1009846009171 ATP-binding [chemical binding]; other site 1009846009172 hypothetical protein; Provisional; Region: PRK05287 1009846009173 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1009846009174 active site 1009846009175 8-oxo-dGMP binding site [chemical binding]; other site 1009846009176 nudix motif; other site 1009846009177 metal binding site [ion binding]; metal-binding site 1009846009178 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1009846009179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846009180 Walker A motif; other site 1009846009181 ATP binding site [chemical binding]; other site 1009846009182 Walker B motif; other site 1009846009183 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1009846009184 heterotetramer interface [polypeptide binding]; other site 1009846009185 active site pocket [active] 1009846009186 cleavage site 1009846009187 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1009846009188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1009846009189 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1009846009190 SEC-C motif; Region: SEC-C; pfam02810 1009846009191 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1009846009192 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1009846009193 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1009846009194 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1009846009195 catalytic triad [active] 1009846009196 dimer interface [polypeptide binding]; other site 1009846009197 cell division protein FtsZ; Validated; Region: PRK09330 1009846009198 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1009846009199 nucleotide binding site [chemical binding]; other site 1009846009200 SulA interaction site; other site 1009846009201 cell division protein FtsA; Region: ftsA; TIGR01174 1009846009202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1009846009203 nucleotide binding site [chemical binding]; other site 1009846009204 Cell division protein FtsA; Region: FtsA; pfam14450 1009846009205 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1009846009206 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1009846009207 Cell division protein FtsQ; Region: FtsQ; pfam03799 1009846009208 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1009846009209 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1009846009210 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009846009211 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1009846009212 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009846009213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846009214 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846009215 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1009846009216 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1009846009217 active site 1009846009218 homodimer interface [polypeptide binding]; other site 1009846009219 cell division protein FtsW; Region: ftsW; TIGR02614 1009846009220 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 1009846009221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846009222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846009223 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1009846009224 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1009846009225 Mg++ binding site [ion binding]; other site 1009846009226 putative catalytic motif [active] 1009846009227 putative substrate binding site [chemical binding]; other site 1009846009228 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1009846009229 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009846009230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846009231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846009232 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1009846009233 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1009846009234 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846009235 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846009236 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1009846009237 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1009846009238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009846009239 Cell division protein FtsL; Region: FtsL; cl11433 1009846009240 MraW methylase family; Region: Methyltransf_5; cl17771 1009846009241 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1009846009242 cell division protein MraZ; Reviewed; Region: PRK00326 1009846009243 MraZ protein; Region: MraZ; pfam02381 1009846009244 MraZ protein; Region: MraZ; pfam02381 1009846009245 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1009846009246 diiron binding motif [ion binding]; other site 1009846009247 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846009248 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846009249 trimer interface [polypeptide binding]; other site 1009846009250 eyelet of channel; other site 1009846009251 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1009846009252 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1009846009253 acyl-activating enzyme (AAE) consensus motif; other site 1009846009254 putative AMP binding site [chemical binding]; other site 1009846009255 putative active site [active] 1009846009256 putative CoA binding site [chemical binding]; other site 1009846009257 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1009846009258 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1009846009259 putative molybdopterin cofactor binding site [chemical binding]; other site 1009846009260 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1009846009261 putative molybdopterin cofactor binding site; other site 1009846009262 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846009263 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846009264 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846009265 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1009846009266 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1009846009267 homotrimer interaction site [polypeptide binding]; other site 1009846009268 putative active site [active] 1009846009269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846009270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846009271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846009272 dimerization interface [polypeptide binding]; other site 1009846009273 enoyl-CoA hydratase; Provisional; Region: PRK05862 1009846009274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846009275 substrate binding site [chemical binding]; other site 1009846009276 oxyanion hole (OAH) forming residues; other site 1009846009277 trimer interface [polypeptide binding]; other site 1009846009278 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1009846009279 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846009280 NAD(P) binding site [chemical binding]; other site 1009846009281 catalytic residues [active] 1009846009282 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1009846009283 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846009284 dimer interface [polypeptide binding]; other site 1009846009285 active site 1009846009286 enoyl-CoA hydratase; Provisional; Region: PRK08140 1009846009287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846009288 substrate binding site [chemical binding]; other site 1009846009289 oxyanion hole (OAH) forming residues; other site 1009846009290 trimer interface [polypeptide binding]; other site 1009846009291 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1009846009292 CoenzymeA binding site [chemical binding]; other site 1009846009293 subunit interaction site [polypeptide binding]; other site 1009846009294 PHB binding site; other site 1009846009295 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1009846009296 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1009846009297 active site 1009846009298 AMP binding site [chemical binding]; other site 1009846009299 homodimer interface [polypeptide binding]; other site 1009846009300 acyl-activating enzyme (AAE) consensus motif; other site 1009846009301 CoA binding site [chemical binding]; other site 1009846009302 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1009846009303 MltA specific insert domain; Region: MltA; smart00925 1009846009304 3D domain; Region: 3D; pfam06725 1009846009305 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1009846009306 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1009846009307 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1009846009308 substrate binding site [chemical binding]; other site 1009846009309 hexamer interface [polypeptide binding]; other site 1009846009310 metal binding site [ion binding]; metal-binding site 1009846009311 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1009846009312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846009313 motif II; other site 1009846009314 anthranilate synthase component I; Provisional; Region: PRK13565 1009846009315 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1009846009316 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1009846009317 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1009846009318 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1009846009319 glutamine binding [chemical binding]; other site 1009846009320 catalytic triad [active] 1009846009321 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1009846009322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1009846009323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1009846009324 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1009846009325 active site 1009846009326 ribulose/triose binding site [chemical binding]; other site 1009846009327 phosphate binding site [ion binding]; other site 1009846009328 substrate (anthranilate) binding pocket [chemical binding]; other site 1009846009329 product (indole) binding pocket [chemical binding]; other site 1009846009330 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1009846009331 putative active site [active] 1009846009332 putative metal binding residues [ion binding]; other site 1009846009333 signature motif; other site 1009846009334 putative triphosphate binding site [ion binding]; other site 1009846009335 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1009846009336 ligand binding site [chemical binding]; other site 1009846009337 active site 1009846009338 UGI interface [polypeptide binding]; other site 1009846009339 catalytic site [active] 1009846009340 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1009846009341 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846009342 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1009846009343 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1009846009344 PDZ domain; Region: PDZ_2; pfam13180 1009846009345 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1009846009346 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1009846009347 dimerization domain [polypeptide binding]; other site 1009846009348 dimer interface [polypeptide binding]; other site 1009846009349 catalytic residues [active] 1009846009350 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 1009846009351 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1009846009352 GTP-binding protein YchF; Reviewed; Region: PRK09601 1009846009353 YchF GTPase; Region: YchF; cd01900 1009846009354 G1 box; other site 1009846009355 GTP/Mg2+ binding site [chemical binding]; other site 1009846009356 Switch I region; other site 1009846009357 G2 box; other site 1009846009358 Switch II region; other site 1009846009359 G3 box; other site 1009846009360 G4 box; other site 1009846009361 G5 box; other site 1009846009362 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1009846009363 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1009846009364 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1009846009365 Protein of unknown function (DUF419); Region: DUF419; cl15265 1009846009366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846009367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846009368 putative substrate translocation pore; other site 1009846009369 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846009370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846009371 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846009372 dimerization interface [polypeptide binding]; other site 1009846009373 substrate binding pocket [chemical binding]; other site 1009846009374 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 1009846009375 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1009846009376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846009377 Walker A/P-loop; other site 1009846009378 ATP binding site [chemical binding]; other site 1009846009379 Q-loop/lid; other site 1009846009380 ABC transporter signature motif; other site 1009846009381 Walker B; other site 1009846009382 D-loop; other site 1009846009383 H-loop/switch region; other site 1009846009384 ABC transporter; Region: ABC_tran_2; pfam12848 1009846009385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1009846009386 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1009846009387 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1009846009388 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1009846009389 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1009846009390 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1009846009391 active site 1009846009392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846009393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846009394 active site 1009846009395 phosphorylation site [posttranslational modification] 1009846009396 intermolecular recognition site; other site 1009846009397 dimerization interface [polypeptide binding]; other site 1009846009398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846009399 DNA binding site [nucleotide binding] 1009846009400 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1009846009401 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1009846009402 tRNA; other site 1009846009403 putative tRNA binding site [nucleotide binding]; other site 1009846009404 putative NADP binding site [chemical binding]; other site 1009846009405 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1009846009406 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1009846009407 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1009846009408 RF-1 domain; Region: RF-1; pfam00472 1009846009409 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1009846009410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846009411 S-adenosylmethionine binding site [chemical binding]; other site 1009846009412 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1009846009413 putative GSH binding site [chemical binding]; other site 1009846009414 catalytic residues [active] 1009846009415 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1009846009416 Flavoprotein; Region: Flavoprotein; pfam02441 1009846009417 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1009846009418 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1009846009419 putative active site [active] 1009846009420 metal binding site [ion binding]; metal-binding site 1009846009421 amino acid transporter; Region: 2A0306; TIGR00909 1009846009422 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846009423 DNA-binding site [nucleotide binding]; DNA binding site 1009846009424 RNA-binding motif; other site 1009846009425 putative chaperone; Provisional; Region: PRK11678 1009846009426 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1009846009427 nucleotide binding site [chemical binding]; other site 1009846009428 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1009846009429 SBD interface [polypeptide binding]; other site 1009846009430 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1009846009431 putative FMN binding site [chemical binding]; other site 1009846009432 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846009433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846009434 putative substrate translocation pore; other site 1009846009435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846009436 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1009846009437 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1009846009438 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1009846009439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846009440 S-adenosylmethionine binding site [chemical binding]; other site 1009846009441 Water Stress and Hypersensitive response; Region: WHy; smart00769 1009846009442 Peptidase family M1; Region: Peptidase_M1; pfam01433 1009846009443 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1009846009444 Zn binding site [ion binding]; other site 1009846009445 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1009846009446 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1009846009447 Cl binding site [ion binding]; other site 1009846009448 oligomer interface [polypeptide binding]; other site 1009846009449 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1009846009450 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1009846009451 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1009846009452 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1009846009453 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1009846009454 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1009846009455 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1009846009456 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1009846009457 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846009458 ligand binding site [chemical binding]; other site 1009846009459 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1009846009460 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1009846009461 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1009846009462 Clp amino terminal domain; Region: Clp_N; pfam02861 1009846009463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846009464 Walker A motif; other site 1009846009465 ATP binding site [chemical binding]; other site 1009846009466 Walker B motif; other site 1009846009467 arginine finger; other site 1009846009468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846009469 Walker A motif; other site 1009846009470 ATP binding site [chemical binding]; other site 1009846009471 Walker B motif; other site 1009846009472 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1009846009473 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1009846009474 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1009846009475 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1009846009476 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1009846009477 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1009846009478 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1009846009479 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1009846009480 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1009846009481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846009482 TPR motif; other site 1009846009483 binding surface 1009846009484 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1009846009485 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1009846009486 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1009846009487 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1009846009488 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846009489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846009490 substrate binding pocket [chemical binding]; other site 1009846009491 membrane-bound complex binding site; other site 1009846009492 hinge residues; other site 1009846009493 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1009846009494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846009495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846009496 sequence-specific DNA binding site [nucleotide binding]; other site 1009846009497 salt bridge; other site 1009846009498 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 1009846009499 D5 N terminal like; Region: D5_N; pfam08706 1009846009500 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1009846009501 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1009846009502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1009846009503 GTP/Mg2+ binding site [chemical binding]; other site 1009846009504 G2 box; other site 1009846009505 Switch I region; other site 1009846009506 G3 box; other site 1009846009507 Switch II region; other site 1009846009508 G4 box; other site 1009846009509 G5 box; other site 1009846009510 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1009846009511 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1009846009512 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1009846009513 catalytic residues [active] 1009846009514 catalytic nucleophile [active] 1009846009515 Presynaptic Site I dimer interface [polypeptide binding]; other site 1009846009516 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1009846009517 Synaptic Flat tetramer interface [polypeptide binding]; other site 1009846009518 Synaptic Site I dimer interface [polypeptide binding]; other site 1009846009519 DNA binding site [nucleotide binding] 1009846009520 Transposase; Region: HTH_Tnp_1; cl17663 1009846009521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1009846009522 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1009846009523 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1009846009524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1009846009525 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1009846009526 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1009846009527 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1009846009528 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1009846009529 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1009846009530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1009846009531 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1009846009532 DNA methylase; Region: N6_N4_Mtase; pfam01555 1009846009533 DNA methylase; Region: N6_N4_Mtase; cl17433 1009846009534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846009535 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1009846009536 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1009846009537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846009538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846009539 non-specific DNA binding site [nucleotide binding]; other site 1009846009540 salt bridge; other site 1009846009541 sequence-specific DNA binding site [nucleotide binding]; other site 1009846009542 integrase; Provisional; Region: PRK09692 1009846009543 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1009846009544 active site 1009846009545 Int/Topo IB signature motif; other site 1009846009546 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1009846009547 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1009846009548 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1009846009549 C-terminal domain interface [polypeptide binding]; other site 1009846009550 putative GSH binding site (G-site) [chemical binding]; other site 1009846009551 dimer interface [polypeptide binding]; other site 1009846009552 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1009846009553 dimer interface [polypeptide binding]; other site 1009846009554 N-terminal domain interface [polypeptide binding]; other site 1009846009555 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1009846009556 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1009846009557 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1009846009558 Qi binding site; other site 1009846009559 intrachain domain interface; other site 1009846009560 interchain domain interface [polypeptide binding]; other site 1009846009561 heme bH binding site [chemical binding]; other site 1009846009562 heme bL binding site [chemical binding]; other site 1009846009563 Qo binding site; other site 1009846009564 interchain domain interface [polypeptide binding]; other site 1009846009565 intrachain domain interface; other site 1009846009566 Qi binding site; other site 1009846009567 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1009846009568 Qo binding site; other site 1009846009569 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1009846009570 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1009846009571 [2Fe-2S] cluster binding site [ion binding]; other site 1009846009572 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1009846009573 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1009846009574 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1009846009575 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1009846009576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846009577 protein binding site [polypeptide binding]; other site 1009846009578 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1009846009579 sec-independent translocase; Provisional; Region: tatB; PRK01919 1009846009580 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 1009846009581 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1009846009582 nucleotide binding site/active site [active] 1009846009583 HIT family signature motif; other site 1009846009584 catalytic residue [active] 1009846009585 Predicted membrane protein [Function unknown]; Region: COG3671 1009846009586 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1009846009587 metal binding site [ion binding]; metal-binding site 1009846009588 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1009846009589 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1009846009590 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1009846009591 substrate binding site [chemical binding]; other site 1009846009592 glutamase interaction surface [polypeptide binding]; other site 1009846009593 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1009846009594 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1009846009595 catalytic residues [active] 1009846009596 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1009846009597 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1009846009598 putative active site [active] 1009846009599 oxyanion strand; other site 1009846009600 catalytic triad [active] 1009846009601 MarC family integral membrane protein; Region: MarC; cl00919 1009846009602 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1009846009603 putative active site pocket [active] 1009846009604 4-fold oligomerization interface [polypeptide binding]; other site 1009846009605 metal binding residues [ion binding]; metal-binding site 1009846009606 3-fold/trimer interface [polypeptide binding]; other site 1009846009607 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 1009846009608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846009609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846009610 homodimer interface [polypeptide binding]; other site 1009846009611 catalytic residue [active] 1009846009612 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1009846009613 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1009846009614 NAD binding site [chemical binding]; other site 1009846009615 dimerization interface [polypeptide binding]; other site 1009846009616 product binding site; other site 1009846009617 substrate binding site [chemical binding]; other site 1009846009618 zinc binding site [ion binding]; other site 1009846009619 catalytic residues [active] 1009846009620 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1009846009621 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1009846009622 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1009846009623 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1009846009624 hinge; other site 1009846009625 active site 1009846009626 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1009846009627 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009846009628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1009846009629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1009846009630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1009846009631 Walker A/P-loop; other site 1009846009632 ATP binding site [chemical binding]; other site 1009846009633 Q-loop/lid; other site 1009846009634 ABC transporter signature motif; other site 1009846009635 Walker B; other site 1009846009636 D-loop; other site 1009846009637 H-loop/switch region; other site 1009846009638 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1009846009639 anti sigma factor interaction site; other site 1009846009640 regulatory phosphorylation site [posttranslational modification]; other site 1009846009641 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1009846009642 VacJ like lipoprotein; Region: VacJ; cl01073 1009846009643 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1009846009644 mce related protein; Region: MCE; pfam02470 1009846009645 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1009846009646 Permease; Region: Permease; pfam02405 1009846009647 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1009846009648 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1009846009649 Walker A/P-loop; other site 1009846009650 ATP binding site [chemical binding]; other site 1009846009651 Q-loop/lid; other site 1009846009652 ABC transporter signature motif; other site 1009846009653 Walker B; other site 1009846009654 D-loop; other site 1009846009655 H-loop/switch region; other site 1009846009656 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1009846009657 thiamine phosphate binding site [chemical binding]; other site 1009846009658 active site 1009846009659 pyrophosphate binding site [ion binding]; other site 1009846009660 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1009846009661 ThiS interaction site; other site 1009846009662 putative active site [active] 1009846009663 tetramer interface [polypeptide binding]; other site 1009846009664 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1009846009665 thiS-thiF/thiG interaction site; other site 1009846009666 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1009846009667 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1009846009668 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1009846009669 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1009846009670 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1009846009671 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1009846009672 amino acid carrier protein; Region: agcS; TIGR00835 1009846009673 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1009846009674 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1009846009675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846009676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846009677 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1009846009678 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1009846009679 active site 1009846009680 dimer interface [polypeptide binding]; other site 1009846009681 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1009846009682 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1009846009683 active site 1009846009684 FMN binding site [chemical binding]; other site 1009846009685 substrate binding site [chemical binding]; other site 1009846009686 3Fe-4S cluster binding site [ion binding]; other site 1009846009687 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1009846009688 domain interface; other site 1009846009689 Transposase IS200 like; Region: Y1_Tnp; cl00848 1009846009690 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1009846009691 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1009846009692 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1009846009693 putative active site [active] 1009846009694 catalytic site [active] 1009846009695 putative metal binding site [ion binding]; other site 1009846009696 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1009846009697 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1009846009698 Walker A/P-loop; other site 1009846009699 ATP binding site [chemical binding]; other site 1009846009700 Q-loop/lid; other site 1009846009701 ABC transporter signature motif; other site 1009846009702 Walker B; other site 1009846009703 D-loop; other site 1009846009704 H-loop/switch region; other site 1009846009705 TOBE domain; Region: TOBE_2; pfam08402 1009846009706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009846009707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846009708 dimer interface [polypeptide binding]; other site 1009846009709 conserved gate region; other site 1009846009710 putative PBP binding loops; other site 1009846009711 ABC-ATPase subunit interface; other site 1009846009712 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1009846009713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846009714 dimer interface [polypeptide binding]; other site 1009846009715 conserved gate region; other site 1009846009716 putative PBP binding loops; other site 1009846009717 ABC-ATPase subunit interface; other site 1009846009718 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009846009719 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1009846009720 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1009846009721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1009846009722 Zn2+ binding site [ion binding]; other site 1009846009723 Mg2+ binding site [ion binding]; other site 1009846009724 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1009846009725 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1009846009726 active site 1009846009727 dimer interface [polypeptide binding]; other site 1009846009728 metal binding site [ion binding]; metal-binding site 1009846009729 shikimate kinase; Reviewed; Region: aroK; PRK00131 1009846009730 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1009846009731 ADP binding site [chemical binding]; other site 1009846009732 magnesium binding site [ion binding]; other site 1009846009733 putative shikimate binding site; other site 1009846009734 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1009846009735 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1009846009736 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1009846009737 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1009846009738 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1009846009739 Transglycosylase; Region: Transgly; pfam00912 1009846009740 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009846009741 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1009846009742 putative iron binding site [ion binding]; other site 1009846009743 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1009846009744 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1009846009745 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1009846009746 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1009846009747 Moco binding site; other site 1009846009748 metal coordination site [ion binding]; other site 1009846009749 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1009846009750 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1009846009751 ResB-like family; Region: ResB; pfam05140 1009846009752 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1009846009753 ResB-like family; Region: ResB; pfam05140 1009846009754 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1009846009755 Cytochrome c; Region: Cytochrom_C; cl11414 1009846009756 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1009846009757 G1 box; other site 1009846009758 GTP/Mg2+ binding site [chemical binding]; other site 1009846009759 Switch I region; other site 1009846009760 G2 box; other site 1009846009761 G3 box; other site 1009846009762 Switch II region; other site 1009846009763 G4 box; other site 1009846009764 G5 box; other site 1009846009765 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1009846009766 dimer interface [polypeptide binding]; other site 1009846009767 active site 1009846009768 aspartate-rich active site metal binding site; other site 1009846009769 allosteric magnesium binding site [ion binding]; other site 1009846009770 Schiff base residues; other site 1009846009771 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1009846009772 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1009846009773 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1009846009774 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1009846009775 DsbD alpha interface [polypeptide binding]; other site 1009846009776 catalytic residues [active] 1009846009777 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1009846009778 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1009846009779 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1009846009780 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1009846009781 alphaNTD homodimer interface [polypeptide binding]; other site 1009846009782 alphaNTD - beta interaction site [polypeptide binding]; other site 1009846009783 alphaNTD - beta' interaction site [polypeptide binding]; other site 1009846009784 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1009846009785 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1009846009786 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1009846009787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1009846009788 RNA binding surface [nucleotide binding]; other site 1009846009789 30S ribosomal protein S11; Validated; Region: PRK05309 1009846009790 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1009846009791 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1009846009792 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1009846009793 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1009846009794 rRNA binding site [nucleotide binding]; other site 1009846009795 predicted 30S ribosome binding site; other site 1009846009796 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1009846009797 SecY translocase; Region: SecY; pfam00344 1009846009798 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1009846009799 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1009846009800 23S rRNA binding site [nucleotide binding]; other site 1009846009801 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1009846009802 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1009846009803 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1009846009804 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1009846009805 5S rRNA interface [nucleotide binding]; other site 1009846009806 L27 interface [polypeptide binding]; other site 1009846009807 23S rRNA interface [nucleotide binding]; other site 1009846009808 L5 interface [polypeptide binding]; other site 1009846009809 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1009846009810 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1009846009811 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1009846009812 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1009846009813 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1009846009814 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1009846009815 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1009846009816 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1009846009817 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1009846009818 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1009846009819 RNA binding site [nucleotide binding]; other site 1009846009820 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1009846009821 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1009846009822 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1009846009823 23S rRNA interface [nucleotide binding]; other site 1009846009824 putative translocon interaction site; other site 1009846009825 signal recognition particle (SRP54) interaction site; other site 1009846009826 L23 interface [polypeptide binding]; other site 1009846009827 trigger factor interaction site; other site 1009846009828 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1009846009829 23S rRNA interface [nucleotide binding]; other site 1009846009830 5S rRNA interface [nucleotide binding]; other site 1009846009831 putative antibiotic binding site [chemical binding]; other site 1009846009832 L25 interface [polypeptide binding]; other site 1009846009833 L27 interface [polypeptide binding]; other site 1009846009834 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1009846009835 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1009846009836 G-X-X-G motif; other site 1009846009837 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1009846009838 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1009846009839 putative translocon binding site; other site 1009846009840 protein-rRNA interface [nucleotide binding]; other site 1009846009841 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1009846009842 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1009846009843 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1009846009844 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1009846009845 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1009846009846 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1009846009847 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1009846009848 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1009846009849 elongation factor Tu; Reviewed; Region: PRK00049 1009846009850 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1009846009851 G1 box; other site 1009846009852 GEF interaction site [polypeptide binding]; other site 1009846009853 GTP/Mg2+ binding site [chemical binding]; other site 1009846009854 Switch I region; other site 1009846009855 G2 box; other site 1009846009856 G3 box; other site 1009846009857 Switch II region; other site 1009846009858 G4 box; other site 1009846009859 G5 box; other site 1009846009860 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1009846009861 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1009846009862 Antibiotic Binding Site [chemical binding]; other site 1009846009863 elongation factor G; Reviewed; Region: PRK00007 1009846009864 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1009846009865 G1 box; other site 1009846009866 putative GEF interaction site [polypeptide binding]; other site 1009846009867 GTP/Mg2+ binding site [chemical binding]; other site 1009846009868 Switch I region; other site 1009846009869 G2 box; other site 1009846009870 G3 box; other site 1009846009871 Switch II region; other site 1009846009872 G4 box; other site 1009846009873 G5 box; other site 1009846009874 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1009846009875 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1009846009876 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1009846009877 30S ribosomal protein S7; Validated; Region: PRK05302 1009846009878 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1009846009879 S17 interaction site [polypeptide binding]; other site 1009846009880 S8 interaction site; other site 1009846009881 16S rRNA interaction site [nucleotide binding]; other site 1009846009882 streptomycin interaction site [chemical binding]; other site 1009846009883 23S rRNA interaction site [nucleotide binding]; other site 1009846009884 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1009846009885 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1009846009886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846009887 ATP binding site [chemical binding]; other site 1009846009888 putative Mg++ binding site [ion binding]; other site 1009846009889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846009890 nucleotide binding region [chemical binding]; other site 1009846009891 ATP-binding site [chemical binding]; other site 1009846009892 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1009846009893 HRDC domain; Region: HRDC; pfam00570 1009846009894 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1009846009895 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1009846009896 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1009846009897 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1009846009898 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1009846009899 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1009846009900 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1009846009901 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1009846009902 DNA binding site [nucleotide binding] 1009846009903 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1009846009904 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1009846009905 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1009846009906 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1009846009907 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1009846009908 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1009846009909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1009846009910 RPB3 interaction site [polypeptide binding]; other site 1009846009911 RPB1 interaction site [polypeptide binding]; other site 1009846009912 RPB11 interaction site [polypeptide binding]; other site 1009846009913 RPB10 interaction site [polypeptide binding]; other site 1009846009914 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1009846009915 peripheral dimer interface [polypeptide binding]; other site 1009846009916 core dimer interface [polypeptide binding]; other site 1009846009917 L10 interface [polypeptide binding]; other site 1009846009918 L11 interface [polypeptide binding]; other site 1009846009919 putative EF-Tu interaction site [polypeptide binding]; other site 1009846009920 putative EF-G interaction site [polypeptide binding]; other site 1009846009921 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1009846009922 23S rRNA interface [nucleotide binding]; other site 1009846009923 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1009846009924 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1009846009925 mRNA/rRNA interface [nucleotide binding]; other site 1009846009926 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1009846009927 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1009846009928 23S rRNA interface [nucleotide binding]; other site 1009846009929 L7/L12 interface [polypeptide binding]; other site 1009846009930 putative thiostrepton binding site; other site 1009846009931 L25 interface [polypeptide binding]; other site 1009846009932 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1009846009933 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1009846009934 putative homodimer interface [polypeptide binding]; other site 1009846009935 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1009846009936 heterodimer interface [polypeptide binding]; other site 1009846009937 homodimer interface [polypeptide binding]; other site 1009846009938 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1009846009939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846009940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846009941 putative substrate translocation pore; other site 1009846009942 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1009846009943 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1009846009944 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1009846009945 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1009846009946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846009947 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1009846009948 putative dimerization interface [polypeptide binding]; other site 1009846009949 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1009846009950 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1009846009951 THF binding site; other site 1009846009952 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1009846009953 substrate binding site [chemical binding]; other site 1009846009954 THF binding site; other site 1009846009955 zinc-binding site [ion binding]; other site 1009846009956 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846009957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846009958 putative substrate translocation pore; other site 1009846009959 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1009846009960 agmatinase; Region: agmatinase; TIGR01230 1009846009961 oligomer interface [polypeptide binding]; other site 1009846009962 putative active site [active] 1009846009963 Mn binding site [ion binding]; other site 1009846009964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846009965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846009966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846009967 dimerization interface [polypeptide binding]; other site 1009846009968 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846009969 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846009970 putative DNA binding site [nucleotide binding]; other site 1009846009971 putative Zn2+ binding site [ion binding]; other site 1009846009972 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846009973 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846009974 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1009846009975 peptidase domain interface [polypeptide binding]; other site 1009846009976 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1009846009977 active site 1009846009978 catalytic triad [active] 1009846009979 calcium binding site [ion binding]; other site 1009846009980 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1009846009981 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1009846009982 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1009846009983 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1009846009984 homodimer interface [polypeptide binding]; other site 1009846009985 NAD binding pocket [chemical binding]; other site 1009846009986 ATP binding pocket [chemical binding]; other site 1009846009987 Mg binding site [ion binding]; other site 1009846009988 active-site loop [active] 1009846009989 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1009846009990 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1009846009991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1009846009992 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1009846009993 PLD-like domain; Region: PLDc_2; pfam13091 1009846009994 putative active site [active] 1009846009995 catalytic site [active] 1009846009996 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1009846009997 PLD-like domain; Region: PLDc_2; pfam13091 1009846009998 putative active site [active] 1009846009999 catalytic site [active] 1009846010000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846010001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846010002 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846010003 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846010004 lysine transporter; Provisional; Region: PRK10836 1009846010005 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1009846010006 aldehyde dehydrogenase family 7 member; Region: PLN02315 1009846010007 tetrameric interface [polypeptide binding]; other site 1009846010008 NAD binding site [chemical binding]; other site 1009846010009 catalytic residues [active] 1009846010010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1009846010011 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1009846010012 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846010013 benzoate transport; Region: 2A0115; TIGR00895 1009846010014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010015 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010016 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010017 trimer interface [polypeptide binding]; other site 1009846010018 eyelet of channel; other site 1009846010019 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1009846010020 active site 1009846010021 tetramer interface [polypeptide binding]; other site 1009846010022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846010023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846010025 dimerization interface [polypeptide binding]; other site 1009846010026 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1009846010027 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1009846010028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1009846010029 active site 1009846010030 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1009846010031 Transglycosylase; Region: Transgly; pfam00912 1009846010032 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1009846010033 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009846010034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846010035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846010036 DNA-binding site [nucleotide binding]; DNA binding site 1009846010037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846010038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846010039 homodimer interface [polypeptide binding]; other site 1009846010040 catalytic residue [active] 1009846010041 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1009846010042 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1009846010043 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846010044 catalytic residues [active] 1009846010045 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1009846010046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846010047 active site 1009846010048 phosphorylation site [posttranslational modification] 1009846010049 intermolecular recognition site; other site 1009846010050 dimerization interface [polypeptide binding]; other site 1009846010051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846010052 DNA binding site [nucleotide binding] 1009846010053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846010054 dimerization interface [polypeptide binding]; other site 1009846010055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846010056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846010057 ATP binding site [chemical binding]; other site 1009846010058 Mg2+ binding site [ion binding]; other site 1009846010059 G-X-G motif; other site 1009846010060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846010061 TAP-like protein; Region: Abhydrolase_4; pfam08386 1009846010062 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1009846010063 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846010064 active site 1009846010065 metal binding site [ion binding]; metal-binding site 1009846010066 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009846010067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846010068 Coenzyme A binding pocket [chemical binding]; other site 1009846010069 LysE type translocator; Region: LysE; cl00565 1009846010070 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010071 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010072 trimer interface [polypeptide binding]; other site 1009846010073 eyelet of channel; other site 1009846010074 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1009846010075 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1009846010076 Cytochrome c [Energy production and conversion]; Region: COG3258 1009846010077 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846010078 Cytochrome c; Region: Cytochrom_C; cl11414 1009846010079 Cytochrome c; Region: Cytochrom_C; cl11414 1009846010080 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846010081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846010082 substrate binding pocket [chemical binding]; other site 1009846010083 membrane-bound complex binding site; other site 1009846010084 hinge residues; other site 1009846010085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010086 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846010087 putative substrate translocation pore; other site 1009846010088 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1009846010089 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1009846010090 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1009846010091 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846010092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846010093 DNA-binding site [nucleotide binding]; DNA binding site 1009846010094 FCD domain; Region: FCD; pfam07729 1009846010095 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1009846010096 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1009846010097 putative active site pocket [active] 1009846010098 putative metal binding site [ion binding]; other site 1009846010099 putative oxidoreductase; Provisional; Region: PRK10083 1009846010100 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1009846010101 putative NAD(P) binding site [chemical binding]; other site 1009846010102 catalytic Zn binding site [ion binding]; other site 1009846010103 structural Zn binding site [ion binding]; other site 1009846010104 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1009846010105 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1009846010106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010107 putative substrate translocation pore; other site 1009846010108 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1009846010109 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846010110 N-terminal plug; other site 1009846010111 ligand-binding site [chemical binding]; other site 1009846010112 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1009846010113 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010114 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010115 trimer interface [polypeptide binding]; other site 1009846010116 eyelet of channel; other site 1009846010117 benzoate transport; Region: 2A0115; TIGR00895 1009846010118 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846010119 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 1009846010120 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1009846010121 alpha subunit interface [polypeptide binding]; other site 1009846010122 active site 1009846010123 substrate binding site [chemical binding]; other site 1009846010124 Fe binding site [ion binding]; other site 1009846010125 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1009846010126 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1009846010127 FMN-binding pocket [chemical binding]; other site 1009846010128 flavin binding motif; other site 1009846010129 phosphate binding motif [ion binding]; other site 1009846010130 beta-alpha-beta structure motif; other site 1009846010131 NAD binding pocket [chemical binding]; other site 1009846010132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846010133 catalytic loop [active] 1009846010134 iron binding site [ion binding]; other site 1009846010135 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846010136 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 1009846010137 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1009846010138 alpha subunit interface [polypeptide binding]; other site 1009846010139 active site 1009846010140 substrate binding site [chemical binding]; other site 1009846010141 Fe binding site [ion binding]; other site 1009846010142 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846010143 MarR family; Region: MarR; pfam01047 1009846010144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846010145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846010146 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1009846010147 isovaleryl-CoA dehydrogenase; Region: PLN02519 1009846010148 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1009846010149 substrate binding site [chemical binding]; other site 1009846010150 FAD binding site [chemical binding]; other site 1009846010151 catalytic base [active] 1009846010152 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1009846010153 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1009846010154 enoyl-CoA hydratase; Provisional; Region: PRK05995 1009846010155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846010156 substrate binding site [chemical binding]; other site 1009846010157 oxyanion hole (OAH) forming residues; other site 1009846010158 trimer interface [polypeptide binding]; other site 1009846010159 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1009846010160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1009846010161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1009846010162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1009846010163 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1009846010164 carboxyltransferase (CT) interaction site; other site 1009846010165 biotinylation site [posttranslational modification]; other site 1009846010166 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 1009846010167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846010168 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 1009846010169 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 1009846010170 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 1009846010171 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 1009846010172 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1009846010173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846010174 ligand binding site [chemical binding]; other site 1009846010175 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1009846010176 trimer interface [polypeptide binding]; other site 1009846010177 Haemagglutinin; Region: HIM; pfam05662 1009846010178 YadA-like C-terminal region; Region: YadA; pfam03895 1009846010179 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1009846010180 Predicted flavoprotein [General function prediction only]; Region: COG0431 1009846010181 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846010182 NIPSNAP; Region: NIPSNAP; pfam07978 1009846010183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846010184 Coenzyme A binding pocket [chemical binding]; other site 1009846010185 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1009846010186 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1009846010187 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1009846010188 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1009846010189 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1009846010190 Walker A/P-loop; other site 1009846010191 ATP binding site [chemical binding]; other site 1009846010192 Q-loop/lid; other site 1009846010193 ABC transporter signature motif; other site 1009846010194 Walker B; other site 1009846010195 D-loop; other site 1009846010196 H-loop/switch region; other site 1009846010197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1009846010198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846010199 dimer interface [polypeptide binding]; other site 1009846010200 conserved gate region; other site 1009846010201 putative PBP binding loops; other site 1009846010202 ABC-ATPase subunit interface; other site 1009846010203 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846010204 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846010205 conserved cys residue [active] 1009846010206 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1009846010207 metal binding site [ion binding]; metal-binding site 1009846010208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010210 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1009846010211 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1009846010212 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846010213 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846010214 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846010215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846010217 dimerization interface [polypeptide binding]; other site 1009846010218 Ubiquitin-like proteins; Region: UBQ; cl00155 1009846010219 charged pocket; other site 1009846010220 hydrophobic patch; other site 1009846010221 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1009846010222 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846010223 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846010224 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1009846010225 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1009846010226 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1009846010227 ligand binding site; other site 1009846010228 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1009846010229 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846010230 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1009846010231 putative NAD(P) binding site [chemical binding]; other site 1009846010232 active site 1009846010233 putative substrate binding site [chemical binding]; other site 1009846010234 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1009846010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010236 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846010237 putative substrate translocation pore; other site 1009846010238 putative aldolase; Validated; Region: PRK08130 1009846010239 intersubunit interface [polypeptide binding]; other site 1009846010240 active site 1009846010241 Zn2+ binding site [ion binding]; other site 1009846010242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1009846010243 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1009846010244 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846010245 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846010246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846010247 DNA-binding site [nucleotide binding]; DNA binding site 1009846010248 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846010249 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846010250 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846010251 conserved cys residue [active] 1009846010252 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1009846010253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010254 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1009846010255 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1009846010256 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1009846010257 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1009846010258 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846010259 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1009846010260 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1009846010261 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1009846010262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846010263 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 1009846010264 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1009846010265 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1009846010266 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1009846010267 active site 1009846010268 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846010269 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846010270 FMN binding site [chemical binding]; other site 1009846010271 active site 1009846010272 substrate binding site [chemical binding]; other site 1009846010273 catalytic residue [active] 1009846010274 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846010275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010276 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846010277 putative effector binding pocket; other site 1009846010278 dimerization interface [polypeptide binding]; other site 1009846010279 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1009846010280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846010281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846010282 catalytic residue [active] 1009846010283 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846010284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846010285 ABC-ATPase subunit interface; other site 1009846010286 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1009846010287 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1009846010288 Walker A/P-loop; other site 1009846010289 ATP binding site [chemical binding]; other site 1009846010290 Q-loop/lid; other site 1009846010291 ABC transporter signature motif; other site 1009846010292 Walker B; other site 1009846010293 D-loop; other site 1009846010294 H-loop/switch region; other site 1009846010295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846010296 ABC-ATPase subunit interface; other site 1009846010297 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1009846010298 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1009846010299 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1009846010300 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1009846010301 putative ligand binding site [chemical binding]; other site 1009846010302 NAD binding site [chemical binding]; other site 1009846010303 catalytic site [active] 1009846010304 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846010305 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1009846010306 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009846010307 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1009846010308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009846010309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846010310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846010311 active site 1009846010312 catalytic tetrad [active] 1009846010313 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1009846010314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846010315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010316 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1009846010317 putative effector binding pocket; other site 1009846010318 putative dimerization interface [polypeptide binding]; other site 1009846010319 Putative esterase; Region: Esterase; pfam00756 1009846010320 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1009846010321 Lipase (class 2); Region: Lipase_2; pfam01674 1009846010322 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1009846010323 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846010324 catalytic site [active] 1009846010325 DinB superfamily; Region: DinB_2; pfam12867 1009846010326 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846010327 Serine hydrolase; Region: Ser_hydrolase; cl17834 1009846010328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846010329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846010330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1009846010331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1009846010332 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1009846010333 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1009846010334 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1009846010335 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1009846010336 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1009846010337 Walker A/P-loop; other site 1009846010338 ATP binding site [chemical binding]; other site 1009846010339 Q-loop/lid; other site 1009846010340 ABC transporter signature motif; other site 1009846010341 Walker B; other site 1009846010342 D-loop; other site 1009846010343 H-loop/switch region; other site 1009846010344 Cupin domain; Region: Cupin_2; pfam07883 1009846010345 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 1009846010346 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 1009846010347 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1009846010348 choline dehydrogenase; Validated; Region: PRK02106 1009846010349 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846010350 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1009846010351 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1009846010352 tetrameric interface [polypeptide binding]; other site 1009846010353 NAD binding site [chemical binding]; other site 1009846010354 catalytic residues [active] 1009846010355 transcriptional regulator BetI; Validated; Region: PRK00767 1009846010356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846010357 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1009846010358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846010359 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1009846010360 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1009846010361 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1009846010362 active site 1009846010363 TDP-binding site; other site 1009846010364 acceptor substrate-binding pocket; other site 1009846010365 homodimer interface [polypeptide binding]; other site 1009846010366 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010368 putative substrate translocation pore; other site 1009846010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010370 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1009846010371 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1009846010372 Ligand binding site; other site 1009846010373 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1009846010374 Outer membrane efflux protein; Region: OEP; pfam02321 1009846010375 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1009846010376 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846010377 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846010378 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1009846010379 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1009846010380 NAD binding site [chemical binding]; other site 1009846010381 catalytic Zn binding site [ion binding]; other site 1009846010382 structural Zn binding site [ion binding]; other site 1009846010383 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846010384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010385 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846010386 dimerization interface [polypeptide binding]; other site 1009846010387 substrate binding pocket [chemical binding]; other site 1009846010388 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846010389 EamA-like transporter family; Region: EamA; pfam00892 1009846010390 EamA-like transporter family; Region: EamA; pfam00892 1009846010391 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846010392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846010393 DNA-binding site [nucleotide binding]; DNA binding site 1009846010394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846010395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846010396 homodimer interface [polypeptide binding]; other site 1009846010397 catalytic residue [active] 1009846010398 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1009846010399 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1009846010400 sugar binding site [chemical binding]; other site 1009846010401 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846010402 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846010403 conserved cys residue [active] 1009846010404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010405 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1009846010406 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1009846010407 dimer interface [polypeptide binding]; other site 1009846010408 active site 1009846010409 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1009846010410 folate binding site [chemical binding]; other site 1009846010411 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1009846010412 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1009846010413 active site 1009846010414 dimer interface [polypeptide binding]; other site 1009846010415 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1009846010416 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1009846010417 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1009846010418 putative active site [active] 1009846010419 putative FMN binding site [chemical binding]; other site 1009846010420 putative substrate binding site [chemical binding]; other site 1009846010421 putative catalytic residue [active] 1009846010422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846010423 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1009846010424 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846010425 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1009846010426 4Fe-4S binding domain; Region: Fer4; cl02805 1009846010427 Cysteine-rich domain; Region: CCG; pfam02754 1009846010428 Cysteine-rich domain; Region: CCG; pfam02754 1009846010429 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1009846010430 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1009846010431 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1009846010432 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1009846010433 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846010434 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1009846010435 [2Fe-2S] cluster binding site [ion binding]; other site 1009846010436 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1009846010437 putative alpha subunit interface [polypeptide binding]; other site 1009846010438 putative active site [active] 1009846010439 putative substrate binding site [chemical binding]; other site 1009846010440 Fe binding site [ion binding]; other site 1009846010441 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1009846010442 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1009846010443 FAD binding pocket [chemical binding]; other site 1009846010444 FAD binding motif [chemical binding]; other site 1009846010445 phosphate binding motif [ion binding]; other site 1009846010446 beta-alpha-beta structure motif; other site 1009846010447 NAD binding pocket [chemical binding]; other site 1009846010448 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1009846010449 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846010450 catalytic loop [active] 1009846010451 iron binding site [ion binding]; other site 1009846010452 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1009846010453 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1009846010454 Amino acid permease; Region: AA_permease_2; pfam13520 1009846010455 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1009846010456 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1009846010457 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1009846010458 putative active site [active] 1009846010459 putative substrate binding site [chemical binding]; other site 1009846010460 putative cosubstrate binding site; other site 1009846010461 catalytic site [active] 1009846010462 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1009846010463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010464 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846010465 dimerization interface [polypeptide binding]; other site 1009846010466 substrate binding pocket [chemical binding]; other site 1009846010467 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1009846010468 Sulfatase; Region: Sulfatase; cl17466 1009846010469 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1009846010470 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1009846010471 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1009846010472 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010473 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010474 trimer interface [polypeptide binding]; other site 1009846010475 eyelet of channel; other site 1009846010476 H+ Antiporter protein; Region: 2A0121; TIGR00900 1009846010477 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1009846010478 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846010479 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1009846010480 conserved cys residue [active] 1009846010481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010482 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846010483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010484 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 1009846010485 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1009846010486 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1009846010487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846010488 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 1009846010489 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846010490 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846010491 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846010492 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1009846010493 homotrimer interaction site [polypeptide binding]; other site 1009846010494 putative active site [active] 1009846010495 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846010496 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846010497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846010498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846010500 dimerization interface [polypeptide binding]; other site 1009846010501 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1009846010502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846010503 catalytic residue [active] 1009846010504 malic enzyme; Reviewed; Region: PRK12861 1009846010505 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1009846010506 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1009846010507 putative NAD(P) binding site [chemical binding]; other site 1009846010508 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1009846010509 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1009846010510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846010512 dimerization interface [polypeptide binding]; other site 1009846010513 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010514 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010515 trimer interface [polypeptide binding]; other site 1009846010516 eyelet of channel; other site 1009846010517 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1009846010518 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1009846010519 Trp docking motif [polypeptide binding]; other site 1009846010520 active site 1009846010521 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846010522 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846010523 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1009846010524 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1009846010525 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1009846010526 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1009846010527 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846010528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846010529 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1009846010530 active site 1009846010531 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846010532 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1009846010533 Protein of unknown function (DUF971); Region: DUF971; cl01414 1009846010534 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1009846010535 substrate binding pocket [chemical binding]; other site 1009846010536 active site 1009846010537 iron coordination sites [ion binding]; other site 1009846010538 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846010539 short chain dehydrogenase; Provisional; Region: PRK06197 1009846010540 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1009846010541 putative NAD(P) binding site [chemical binding]; other site 1009846010542 active site 1009846010543 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846010544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846010545 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1009846010546 NAD binding site [chemical binding]; other site 1009846010547 homotetramer interface [polypeptide binding]; other site 1009846010548 homodimer interface [polypeptide binding]; other site 1009846010549 active site 1009846010550 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846010551 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846010552 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1009846010553 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009846010554 putative active site pocket [active] 1009846010555 metal binding site [ion binding]; metal-binding site 1009846010556 short chain dehydrogenase; Provisional; Region: PRK08628 1009846010557 classical (c) SDRs; Region: SDR_c; cd05233 1009846010558 NAD(P) binding site [chemical binding]; other site 1009846010559 active site 1009846010560 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1009846010561 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846010562 Walker A/P-loop; other site 1009846010563 ATP binding site [chemical binding]; other site 1009846010564 Q-loop/lid; other site 1009846010565 ABC transporter signature motif; other site 1009846010566 Walker B; other site 1009846010567 D-loop; other site 1009846010568 H-loop/switch region; other site 1009846010569 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846010570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846010571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846010572 TM-ABC transporter signature motif; other site 1009846010573 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1009846010574 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009846010575 putative ligand binding site [chemical binding]; other site 1009846010576 Amidohydrolase; Region: Amidohydro_2; pfam04909 1009846010577 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1009846010578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846010579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846010580 DNA-binding site [nucleotide binding]; DNA binding site 1009846010581 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846010582 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846010583 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846010584 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846010585 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1009846010586 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1009846010587 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846010588 metal binding site [ion binding]; metal-binding site 1009846010589 active site 1009846010590 I-site; other site 1009846010591 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1009846010592 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846010593 ligand binding site [chemical binding]; other site 1009846010594 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846010595 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009846010596 ligand binding site [chemical binding]; other site 1009846010597 flexible hinge region; other site 1009846010598 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009846010599 putative switch regulator; other site 1009846010600 non-specific DNA interactions [nucleotide binding]; other site 1009846010601 DNA binding site [nucleotide binding] 1009846010602 sequence specific DNA binding site [nucleotide binding]; other site 1009846010603 putative cAMP binding site [chemical binding]; other site 1009846010604 acyl-CoA synthetase; Validated; Region: PRK08162 1009846010605 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1009846010606 acyl-activating enzyme (AAE) consensus motif; other site 1009846010607 putative active site [active] 1009846010608 AMP binding site [chemical binding]; other site 1009846010609 putative CoA binding site [chemical binding]; other site 1009846010610 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1009846010611 putative FMN binding site [chemical binding]; other site 1009846010612 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846010613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010614 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846010615 putative effector binding pocket; other site 1009846010616 dimerization interface [polypeptide binding]; other site 1009846010617 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846010618 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846010619 dimerization interface [polypeptide binding]; other site 1009846010620 ligand binding site [chemical binding]; other site 1009846010621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846010622 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846010623 TM-ABC transporter signature motif; other site 1009846010624 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1009846010625 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1009846010626 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846010627 TM-ABC transporter signature motif; other site 1009846010628 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1009846010629 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846010630 Walker A/P-loop; other site 1009846010631 ATP binding site [chemical binding]; other site 1009846010632 Q-loop/lid; other site 1009846010633 ABC transporter signature motif; other site 1009846010634 Walker B; other site 1009846010635 D-loop; other site 1009846010636 H-loop/switch region; other site 1009846010637 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846010638 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846010639 Walker A/P-loop; other site 1009846010640 ATP binding site [chemical binding]; other site 1009846010641 Q-loop/lid; other site 1009846010642 ABC transporter signature motif; other site 1009846010643 Walker B; other site 1009846010644 D-loop; other site 1009846010645 H-loop/switch region; other site 1009846010646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846010647 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1009846010648 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1009846010649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846010650 DNA binding residues [nucleotide binding] 1009846010651 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1009846010652 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846010653 inhibitor-cofactor binding pocket; inhibition site 1009846010654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846010655 catalytic residue [active] 1009846010656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846010657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010658 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1009846010659 putative dimerization interface [polypeptide binding]; other site 1009846010660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846010661 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1009846010662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846010663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846010664 DNA binding site [nucleotide binding] 1009846010665 domain linker motif; other site 1009846010666 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1009846010667 putative dimerization interface [polypeptide binding]; other site 1009846010668 putative ligand binding site [chemical binding]; other site 1009846010669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010670 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846010671 putative substrate translocation pore; other site 1009846010672 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1009846010673 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009846010674 active site pocket [active] 1009846010675 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1009846010676 IHF dimer interface [polypeptide binding]; other site 1009846010677 IHF - DNA interface [nucleotide binding]; other site 1009846010678 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010679 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010680 eyelet of channel; other site 1009846010681 trimer interface [polypeptide binding]; other site 1009846010682 Leucine rich repeat; Region: LRR_8; pfam13855 1009846010683 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1009846010684 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1009846010685 active site 1009846010686 ATP binding site [chemical binding]; other site 1009846010687 substrate binding site [chemical binding]; other site 1009846010688 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846010689 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1009846010690 CopC domain; Region: CopC; pfam04234 1009846010691 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1009846010692 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1009846010693 putative hydrophobic ligand binding site [chemical binding]; other site 1009846010694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846010695 catalytic loop [active] 1009846010696 iron binding site [ion binding]; other site 1009846010697 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1009846010698 GAF domain; Region: GAF; pfam01590 1009846010699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846010700 Walker A motif; other site 1009846010701 ATP binding site [chemical binding]; other site 1009846010702 Walker B motif; other site 1009846010703 arginine finger; other site 1009846010704 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846010705 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 1009846010706 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1009846010707 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1009846010708 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846010709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846010711 dimerization interface [polypeptide binding]; other site 1009846010712 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1009846010713 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1009846010714 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1009846010715 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1009846010716 short chain dehydrogenase; Validated; Region: PRK05855 1009846010717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846010718 classical (c) SDRs; Region: SDR_c; cd05233 1009846010719 NAD(P) binding site [chemical binding]; other site 1009846010720 active site 1009846010721 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1009846010722 active site 1009846010723 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1009846010724 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1009846010725 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1009846010726 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1009846010727 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1009846010728 active site residues [active] 1009846010729 dimer interface [polypeptide binding]; other site 1009846010730 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1009846010731 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846010732 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846010733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846010734 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846010735 active site 1009846010736 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1009846010737 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 1009846010738 active site 1009846010739 acyl-activating enzyme (AAE) consensus motif; other site 1009846010740 putative CoA binding site [chemical binding]; other site 1009846010741 AMP binding site [chemical binding]; other site 1009846010742 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1009846010743 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1009846010744 tetrameric interface [polypeptide binding]; other site 1009846010745 NAD binding site [chemical binding]; other site 1009846010746 catalytic residues [active] 1009846010747 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846010748 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1009846010749 enoyl-CoA hydratase; Provisional; Region: PRK09076 1009846010750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846010751 substrate binding site [chemical binding]; other site 1009846010752 oxyanion hole (OAH) forming residues; other site 1009846010753 trimer interface [polypeptide binding]; other site 1009846010754 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1009846010755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846010756 substrate binding site [chemical binding]; other site 1009846010757 oxyanion hole (OAH) forming residues; other site 1009846010758 trimer interface [polypeptide binding]; other site 1009846010759 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1009846010760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846010761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010762 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1009846010763 putative effector binding pocket; other site 1009846010764 putative dimerization interface [polypeptide binding]; other site 1009846010765 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846010767 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846010768 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1009846010769 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1009846010770 Walker A/P-loop; other site 1009846010771 ATP binding site [chemical binding]; other site 1009846010772 Q-loop/lid; other site 1009846010773 ABC transporter signature motif; other site 1009846010774 Walker B; other site 1009846010775 D-loop; other site 1009846010776 H-loop/switch region; other site 1009846010777 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009846010778 FtsX-like permease family; Region: FtsX; pfam02687 1009846010779 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846010780 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846010781 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846010782 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1009846010783 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1009846010784 dimerization domain [polypeptide binding]; other site 1009846010785 dimer interface [polypeptide binding]; other site 1009846010786 catalytic residues [active] 1009846010787 Protein of unknown function; Region: DUF3658; pfam12395 1009846010788 acid-resistance membrane protein; Provisional; Region: PRK10209 1009846010789 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846010790 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1009846010791 catalytic triad [active] 1009846010792 conserved cis-peptide bond; other site 1009846010793 GntP family permease; Region: GntP_permease; pfam02447 1009846010794 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1009846010795 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1009846010796 hypothetical protein; Provisional; Region: PRK06815 1009846010797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846010798 catalytic residue [active] 1009846010799 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1009846010800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010801 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846010802 dimerization interface [polypeptide binding]; other site 1009846010803 substrate binding pocket [chemical binding]; other site 1009846010804 CopC domain; Region: CopC; pfam04234 1009846010805 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1009846010806 Flavoprotein; Region: Flavoprotein; cl08021 1009846010807 DsrE/DsrF-like family; Region: DrsE; cl00672 1009846010808 DsrE/DsrF-like family; Region: DrsE; cl00672 1009846010809 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846010810 DNA-binding site [nucleotide binding]; DNA binding site 1009846010811 RNA-binding motif; other site 1009846010812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846010813 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1009846010814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846010815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846010816 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846010817 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1009846010818 glutaminase; Provisional; Region: PRK00971 1009846010819 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1009846010820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846010821 active site 1009846010822 phosphorylation site [posttranslational modification] 1009846010823 intermolecular recognition site; other site 1009846010824 dimerization interface [polypeptide binding]; other site 1009846010825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846010826 DNA binding site [nucleotide binding] 1009846010827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846010828 dimer interface [polypeptide binding]; other site 1009846010829 phosphorylation site [posttranslational modification] 1009846010830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846010831 ATP binding site [chemical binding]; other site 1009846010832 Mg2+ binding site [ion binding]; other site 1009846010833 G-X-G motif; other site 1009846010834 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1009846010835 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1009846010836 active site 1009846010837 nucleophile elbow; other site 1009846010838 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1009846010839 Surface antigen; Region: Bac_surface_Ag; pfam01103 1009846010840 rod shape-determining protein MreB; Provisional; Region: PRK13930 1009846010841 MreB and similar proteins; Region: MreB_like; cd10225 1009846010842 nucleotide binding site [chemical binding]; other site 1009846010843 Mg binding site [ion binding]; other site 1009846010844 putative protofilament interaction site [polypeptide binding]; other site 1009846010845 RodZ interaction site [polypeptide binding]; other site 1009846010846 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1009846010847 putative active site [active] 1009846010848 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1009846010849 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1009846010850 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1009846010851 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1009846010852 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1009846010853 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1009846010854 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846010855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010856 The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487 1009846010857 putative dimerization interface [polypeptide binding]; other site 1009846010858 putative substrate binding pocket [chemical binding]; other site 1009846010859 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1009846010860 Protein of unknown function (DUF805); Region: DUF805; cl01224 1009846010861 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1009846010862 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846010863 MarR family; Region: MarR_2; pfam12802 1009846010864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009846010865 HAMP domain; Region: HAMP; pfam00672 1009846010866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846010867 dimer interface [polypeptide binding]; other site 1009846010868 phosphorylation site [posttranslational modification] 1009846010869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846010870 ATP binding site [chemical binding]; other site 1009846010871 Mg2+ binding site [ion binding]; other site 1009846010872 G-X-G motif; other site 1009846010873 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1009846010874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846010875 active site 1009846010876 phosphorylation site [posttranslational modification] 1009846010877 intermolecular recognition site; other site 1009846010878 dimerization interface [polypeptide binding]; other site 1009846010879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846010880 DNA binding site [nucleotide binding] 1009846010881 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1009846010882 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846010883 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846010884 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846010885 putative active site [active] 1009846010886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846010887 Coenzyme A binding pocket [chemical binding]; other site 1009846010888 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1009846010889 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1009846010890 tetramer interface [polypeptide binding]; other site 1009846010891 active site 1009846010892 Mg2+/Mn2+ binding site [ion binding]; other site 1009846010893 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 1009846010894 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1009846010895 Cytochrome P450; Region: p450; cl12078 1009846010896 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 1009846010897 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1009846010898 active site residue [active] 1009846010899 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1009846010900 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846010901 conserved cys residue [active] 1009846010902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846010904 arginine decarboxylase; Provisional; Region: PRK15029 1009846010905 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1009846010906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846010907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846010908 catalytic residue [active] 1009846010909 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1009846010910 arginine:agmatin antiporter; Provisional; Region: PRK10644 1009846010911 Nitronate monooxygenase; Region: NMO; pfam03060 1009846010912 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846010913 FMN binding site [chemical binding]; other site 1009846010914 substrate binding site [chemical binding]; other site 1009846010915 putative catalytic residue [active] 1009846010916 hypothetical protein; Provisional; Region: PRK07907 1009846010917 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1009846010918 metal binding site [ion binding]; metal-binding site 1009846010919 putative dimer interface [polypeptide binding]; other site 1009846010920 putative dehydrogenase; Provisional; Region: PRK10098 1009846010921 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1009846010922 NnrU protein; Region: NnrU; pfam07298 1009846010923 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1009846010924 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1009846010925 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1009846010926 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846010927 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846010928 trimer interface [polypeptide binding]; other site 1009846010929 eyelet of channel; other site 1009846010930 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1009846010931 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1009846010932 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1009846010933 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1009846010934 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1009846010935 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1009846010936 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1009846010937 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1009846010938 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1009846010939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846010940 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1009846010941 NAD(P) binding site [chemical binding]; other site 1009846010942 active site 1009846010943 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1009846010944 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1009846010945 acyl-activating enzyme (AAE) consensus motif; other site 1009846010946 putative AMP binding site [chemical binding]; other site 1009846010947 putative active site [active] 1009846010948 putative CoA binding site [chemical binding]; other site 1009846010949 AAA ATPase domain; Region: AAA_16; pfam13191 1009846010950 AAA domain; Region: AAA_22; pfam13401 1009846010951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846010952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846010953 DNA binding residues [nucleotide binding] 1009846010954 dimerization interface [polypeptide binding]; other site 1009846010955 transcriptional regulator; Provisional; Region: PRK10632 1009846010956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846010957 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846010958 putative effector binding pocket; other site 1009846010959 dimerization interface [polypeptide binding]; other site 1009846010960 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1009846010961 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1009846010962 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1009846010963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846010964 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846010965 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1009846010966 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846010967 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1009846010968 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846010969 Paraquat-inducible protein A; Region: PqiA; pfam04403 1009846010970 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1009846010971 Paraquat-inducible protein A; Region: PqiA; pfam04403 1009846010972 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1009846010973 mce related protein; Region: MCE; pfam02470 1009846010974 mce related protein; Region: MCE; pfam02470 1009846010975 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1009846010976 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1009846010977 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1009846010978 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1009846010979 Trp docking motif [polypeptide binding]; other site 1009846010980 putative active site [active] 1009846010981 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846010982 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846010983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846010984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846010985 non-specific DNA binding site [nucleotide binding]; other site 1009846010986 salt bridge; other site 1009846010987 sequence-specific DNA binding site [nucleotide binding]; other site 1009846010988 Cupin domain; Region: Cupin_2; pfam07883 1009846010989 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1009846010990 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1009846010991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009846010992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846010993 Coenzyme A binding pocket [chemical binding]; other site 1009846010994 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1009846010995 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1009846010996 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1009846010997 active site 1009846010998 metal binding site [ion binding]; metal-binding site 1009846010999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846011000 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1009846011001 spermidine synthase; Provisional; Region: PRK03612 1009846011002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846011003 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1009846011004 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1009846011005 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1009846011006 Short C-terminal domain; Region: SHOCT; pfam09851 1009846011007 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1009846011008 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1009846011009 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1009846011010 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1009846011011 Putative amidotransferase; Region: DUF4066; pfam13278 1009846011012 conserved cys residue [active] 1009846011013 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1009846011014 hydrophobic ligand binding site; other site 1009846011015 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1009846011016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1009846011017 active site 1009846011018 nucleotide binding site [chemical binding]; other site 1009846011019 HIGH motif; other site 1009846011020 KMSKS motif; other site 1009846011021 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1009846011022 nudix motif; other site 1009846011023 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1009846011024 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1009846011025 active site 1009846011026 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846011027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846011028 DNA-binding site [nucleotide binding]; DNA binding site 1009846011029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846011030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846011031 homodimer interface [polypeptide binding]; other site 1009846011032 catalytic residue [active] 1009846011033 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846011034 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1009846011035 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1009846011036 catalytic residues [active] 1009846011037 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1009846011038 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 1009846011039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011041 DNA binding residues [nucleotide binding] 1009846011042 dimerization interface [polypeptide binding]; other site 1009846011043 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 1009846011044 cystathionine beta-lyase; Provisional; Region: PRK09028 1009846011045 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1009846011046 homodimer interface [polypeptide binding]; other site 1009846011047 substrate-cofactor binding pocket; other site 1009846011048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846011049 catalytic residue [active] 1009846011050 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846011051 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846011052 Walker A/P-loop; other site 1009846011053 ATP binding site [chemical binding]; other site 1009846011054 Q-loop/lid; other site 1009846011055 ABC transporter signature motif; other site 1009846011056 Walker B; other site 1009846011057 D-loop; other site 1009846011058 H-loop/switch region; other site 1009846011059 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846011060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011061 dimer interface [polypeptide binding]; other site 1009846011062 conserved gate region; other site 1009846011063 putative PBP binding loops; other site 1009846011064 ABC-ATPase subunit interface; other site 1009846011065 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846011066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846011067 substrate binding pocket [chemical binding]; other site 1009846011068 membrane-bound complex binding site; other site 1009846011069 hinge residues; other site 1009846011070 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1009846011071 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1009846011072 active site 1009846011073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846011074 substrate binding site [chemical binding]; other site 1009846011075 catalytic residues [active] 1009846011076 dimer interface [polypeptide binding]; other site 1009846011077 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1009846011078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011080 dimerization interface [polypeptide binding]; other site 1009846011081 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009846011082 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846011083 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1009846011084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1009846011085 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1009846011086 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1009846011087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009846011088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846011089 Coenzyme A binding pocket [chemical binding]; other site 1009846011090 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1009846011091 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1009846011092 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1009846011093 gamma subunit interface [polypeptide binding]; other site 1009846011094 epsilon subunit interface [polypeptide binding]; other site 1009846011095 LBP interface [polypeptide binding]; other site 1009846011096 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1009846011097 core domain interface [polypeptide binding]; other site 1009846011098 delta subunit interface [polypeptide binding]; other site 1009846011099 epsilon subunit interface [polypeptide binding]; other site 1009846011100 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1009846011101 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1009846011102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1009846011103 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1009846011104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846011106 putative substrate translocation pore; other site 1009846011107 Trehalase; Region: Trehalase; cl17346 1009846011108 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1009846011109 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1009846011110 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1009846011111 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1009846011112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011114 DNA binding residues [nucleotide binding] 1009846011115 dimerization interface [polypeptide binding]; other site 1009846011116 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1009846011117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1009846011118 DNA binding residues [nucleotide binding] 1009846011119 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1009846011120 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1009846011121 active site 1009846011122 dimer interface [polypeptide binding]; other site 1009846011123 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1009846011124 Ligand Binding Site [chemical binding]; other site 1009846011125 Molecular Tunnel; other site 1009846011126 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1009846011127 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1009846011128 catalytic residue [active] 1009846011129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846011130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846011131 DNA binding site [nucleotide binding] 1009846011132 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1009846011133 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846011134 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1009846011135 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846011136 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1009846011137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846011138 catalytic loop [active] 1009846011139 iron binding site [ion binding]; other site 1009846011140 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1009846011141 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1009846011142 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846011143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846011144 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846011145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846011146 Walker A motif; other site 1009846011147 ATP binding site [chemical binding]; other site 1009846011148 Walker B motif; other site 1009846011149 arginine finger; other site 1009846011150 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846011151 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011152 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011153 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011154 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011155 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011156 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1009846011157 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846011158 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1009846011159 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1009846011160 PapC N-terminal domain; Region: PapC_N; pfam13954 1009846011161 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846011162 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846011163 hypothetical protein; Provisional; Region: PRK15301 1009846011164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846011166 active site 1009846011167 phosphorylation site [posttranslational modification] 1009846011168 intermolecular recognition site; other site 1009846011169 dimerization interface [polypeptide binding]; other site 1009846011170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011171 DNA binding residues [nucleotide binding] 1009846011172 dimerization interface [polypeptide binding]; other site 1009846011173 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011174 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1009846011175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1009846011177 phosphorylation site [posttranslational modification] 1009846011178 intermolecular recognition site; other site 1009846011179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011180 DNA binding residues [nucleotide binding] 1009846011181 dimerization interface [polypeptide binding]; other site 1009846011182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1009846011183 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1009846011184 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1009846011185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846011186 dimer interface [polypeptide binding]; other site 1009846011187 putative CheW interface [polypeptide binding]; other site 1009846011188 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1009846011189 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009846011190 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009846011191 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1009846011192 metal-binding site 1009846011193 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1009846011194 putative active site [active] 1009846011195 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1009846011196 Sel1 repeat; Region: Sel1; pfam08238 1009846011197 Sel1-like repeats; Region: SEL1; smart00671 1009846011198 Sel1-like repeats; Region: SEL1; smart00671 1009846011199 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1009846011200 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1009846011201 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846011202 N-terminal plug; other site 1009846011203 ligand-binding site [chemical binding]; other site 1009846011204 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1009846011205 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1009846011206 oligomeric interface; other site 1009846011207 putative active site [active] 1009846011208 homodimer interface [polypeptide binding]; other site 1009846011209 aspartate carbamoyltransferase; Provisional; Region: PRK11891 1009846011210 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1009846011211 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1009846011212 Predicted small secreted protein [Function unknown]; Region: COG5510 1009846011213 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846011214 EamA-like transporter family; Region: EamA; pfam00892 1009846011215 EamA-like transporter family; Region: EamA; pfam00892 1009846011216 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846011217 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846011218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846011219 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1009846011220 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1009846011221 classical (c) SDRs; Region: SDR_c; cd05233 1009846011222 NAD(P) binding site [chemical binding]; other site 1009846011223 active site 1009846011224 Probable dihydrodipicolinate reductase; Region: PLN02775 1009846011225 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 1009846011226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846011227 dimerization interface [polypeptide binding]; other site 1009846011228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846011229 dimer interface [polypeptide binding]; other site 1009846011230 phosphorylation site [posttranslational modification] 1009846011231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846011232 ATP binding site [chemical binding]; other site 1009846011233 Mg2+ binding site [ion binding]; other site 1009846011234 G-X-G motif; other site 1009846011235 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1009846011236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846011237 active site 1009846011238 phosphorylation site [posttranslational modification] 1009846011239 intermolecular recognition site; other site 1009846011240 dimerization interface [polypeptide binding]; other site 1009846011241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846011242 DNA binding site [nucleotide binding] 1009846011243 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1009846011244 pseudo EF-hand loop; other site 1009846011245 EF-hand domain pair; Region: EF_hand_5; pfam13499 1009846011246 peptide binding pocket; other site 1009846011247 Ca2+ binding site [ion binding]; other site 1009846011248 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1009846011249 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1009846011250 short chain dehydrogenase; Provisional; Region: PRK12828 1009846011251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846011252 NAD(P) binding site [chemical binding]; other site 1009846011253 active site 1009846011254 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1009846011255 homotrimer interaction site [polypeptide binding]; other site 1009846011256 putative active site [active] 1009846011257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846011259 putative substrate translocation pore; other site 1009846011260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011263 dimerization interface [polypeptide binding]; other site 1009846011264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011267 dimerization interface [polypeptide binding]; other site 1009846011268 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 1009846011269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846011270 putative NAD(P) binding site [chemical binding]; other site 1009846011271 putative active site [active] 1009846011272 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1009846011273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011274 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846011275 putative substrate translocation pore; other site 1009846011276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846011279 dimerization interface [polypeptide binding]; other site 1009846011280 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1009846011281 classical (c) SDRs; Region: SDR_c; cd05233 1009846011282 NAD(P) binding site [chemical binding]; other site 1009846011283 active site 1009846011284 Predicted metalloprotease [General function prediction only]; Region: COG2321 1009846011285 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1009846011286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011288 DNA binding residues [nucleotide binding] 1009846011289 dimerization interface [polypeptide binding]; other site 1009846011290 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846011291 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846011292 NAD(P) binding site [chemical binding]; other site 1009846011293 catalytic residues [active] 1009846011294 hypothetical protein; Provisional; Region: PRK07481 1009846011295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846011296 inhibitor-cofactor binding pocket; inhibition site 1009846011297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846011298 catalytic residue [active] 1009846011299 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846011300 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1009846011301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846011302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846011303 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846011304 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846011305 trimer interface [polypeptide binding]; other site 1009846011306 eyelet of channel; other site 1009846011307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1009846011308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1009846011309 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1009846011310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011311 dimer interface [polypeptide binding]; other site 1009846011312 conserved gate region; other site 1009846011313 putative PBP binding loops; other site 1009846011314 ABC-ATPase subunit interface; other site 1009846011315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1009846011316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011317 dimer interface [polypeptide binding]; other site 1009846011318 conserved gate region; other site 1009846011319 putative PBP binding loops; other site 1009846011320 ABC-ATPase subunit interface; other site 1009846011321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846011322 DNA binding site [nucleotide binding] 1009846011323 domain linker motif; other site 1009846011324 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1009846011325 putative dimerization interface [polypeptide binding]; other site 1009846011326 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1009846011327 putative ligand binding site [chemical binding]; other site 1009846011328 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1009846011329 active site 1009846011330 catalytic site [active] 1009846011331 putative metal binding site [ion binding]; other site 1009846011332 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1009846011333 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846011334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846011335 Coenzyme A binding pocket [chemical binding]; other site 1009846011336 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846011337 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846011338 FMN binding site [chemical binding]; other site 1009846011339 active site 1009846011340 substrate binding site [chemical binding]; other site 1009846011341 catalytic residue [active] 1009846011342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846011343 dimerization interface [polypeptide binding]; other site 1009846011344 putative DNA binding site [nucleotide binding]; other site 1009846011345 putative Zn2+ binding site [ion binding]; other site 1009846011346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846011347 MarR family; Region: MarR_2; cl17246 1009846011348 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846011349 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1009846011350 metal binding site [ion binding]; metal-binding site 1009846011351 putative dimer interface [polypeptide binding]; other site 1009846011352 Predicted membrane protein [Function unknown]; Region: COG2860 1009846011353 UPF0126 domain; Region: UPF0126; pfam03458 1009846011354 UPF0126 domain; Region: UPF0126; pfam03458 1009846011355 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846011356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011357 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846011358 dimerization interface [polypeptide binding]; other site 1009846011359 substrate binding pocket [chemical binding]; other site 1009846011360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1009846011361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846011362 NAD(P) binding site [chemical binding]; other site 1009846011363 active site 1009846011364 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1009846011365 homotrimer interaction site [polypeptide binding]; other site 1009846011366 putative active site [active] 1009846011367 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846011368 EamA-like transporter family; Region: EamA; pfam00892 1009846011369 Predicted thioesterase [General function prediction only]; Region: COG5496 1009846011370 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1009846011371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846011372 acyl-activating enzyme (AAE) consensus motif; other site 1009846011373 AMP binding site [chemical binding]; other site 1009846011374 active site 1009846011375 CoA binding site [chemical binding]; other site 1009846011376 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1009846011377 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846011378 substrate binding site [chemical binding]; other site 1009846011379 oxyanion hole (OAH) forming residues; other site 1009846011380 trimer interface [polypeptide binding]; other site 1009846011381 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1009846011382 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1009846011383 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846011384 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846011385 dimerization interface [polypeptide binding]; other site 1009846011386 ligand binding site [chemical binding]; other site 1009846011387 Predicted thioesterase [General function prediction only]; Region: COG5496 1009846011388 PAS domain; Region: PAS; smart00091 1009846011389 PAS fold; Region: PAS_4; pfam08448 1009846011390 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1009846011391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846011392 Walker A motif; other site 1009846011393 ATP binding site [chemical binding]; other site 1009846011394 Walker B motif; other site 1009846011395 arginine finger; other site 1009846011396 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846011397 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1009846011398 nucleophile elbow; other site 1009846011399 Patatin phospholipase; Region: DUF3734; pfam12536 1009846011400 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1009846011401 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1009846011402 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846011403 active site 1009846011404 metal binding site [ion binding]; metal-binding site 1009846011405 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1009846011406 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1009846011407 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1009846011408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011409 dimer interface [polypeptide binding]; other site 1009846011410 conserved gate region; other site 1009846011411 putative PBP binding loops; other site 1009846011412 ABC-ATPase subunit interface; other site 1009846011413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011414 putative PBP binding loops; other site 1009846011415 dimer interface [polypeptide binding]; other site 1009846011416 ABC-ATPase subunit interface; other site 1009846011417 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009846011418 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846011419 Walker A/P-loop; other site 1009846011420 ATP binding site [chemical binding]; other site 1009846011421 Q-loop/lid; other site 1009846011422 ABC transporter signature motif; other site 1009846011423 Walker B; other site 1009846011424 D-loop; other site 1009846011425 H-loop/switch region; other site 1009846011426 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1009846011427 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846011428 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846011429 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846011430 putative active site [active] 1009846011431 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1009846011432 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1009846011433 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846011434 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1009846011435 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846011436 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1009846011437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846011438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846011439 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1009846011440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846011441 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1009846011442 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1009846011443 DNA binding residues [nucleotide binding] 1009846011444 dimer interface [polypeptide binding]; other site 1009846011445 [2Fe-2S] cluster binding site [ion binding]; other site 1009846011446 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846011447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846011448 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846011449 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1009846011450 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1009846011451 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1009846011452 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1009846011453 N-terminal domain interface [polypeptide binding]; other site 1009846011454 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1009846011455 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1009846011456 Na binding site [ion binding]; other site 1009846011457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846011458 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1009846011459 NAD(P) binding site [chemical binding]; other site 1009846011460 active site 1009846011461 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1009846011462 dimer interface [polypeptide binding]; other site 1009846011463 substrate binding site [chemical binding]; other site 1009846011464 metal binding site [ion binding]; metal-binding site 1009846011465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011467 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1009846011468 putative dimerization interface [polypeptide binding]; other site 1009846011469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011470 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846011471 putative substrate translocation pore; other site 1009846011472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846011474 putative substrate translocation pore; other site 1009846011475 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846011476 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1009846011477 catalytic triad [active] 1009846011478 conserved cis-peptide bond; other site 1009846011479 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1009846011480 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1009846011481 active site 1009846011482 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846011483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011484 DNA binding residues [nucleotide binding] 1009846011485 dimerization interface [polypeptide binding]; other site 1009846011486 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1009846011487 Predicted transcriptional regulators [Transcription]; Region: COG1733 1009846011488 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1009846011489 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846011490 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846011491 trimer interface [polypeptide binding]; other site 1009846011492 eyelet of channel; other site 1009846011493 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1009846011494 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1009846011495 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846011496 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1009846011497 FOG: CBS domain [General function prediction only]; Region: COG0517 1009846011498 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1009846011499 dimerization interface [polypeptide binding]; other site 1009846011500 active site 1009846011501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846011502 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1009846011503 Autoinducer synthetase; Region: Autoind_synth; cl17404 1009846011504 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1009846011505 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1009846011506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846011507 DNA binding residues [nucleotide binding] 1009846011508 dimerization interface [polypeptide binding]; other site 1009846011509 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1009846011510 MgtC family; Region: MgtC; pfam02308 1009846011511 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1009846011512 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846011513 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1009846011514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846011515 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846011516 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1009846011517 putative active site [active] 1009846011518 putative metal binding site [ion binding]; other site 1009846011519 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1009846011520 putative FMN binding site [chemical binding]; other site 1009846011521 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1009846011522 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846011523 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846011524 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846011525 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846011526 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846011527 trimer interface [polypeptide binding]; other site 1009846011528 eyelet of channel; other site 1009846011529 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1009846011530 [2Fe-2S] cluster binding site [ion binding]; other site 1009846011531 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846011532 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1009846011533 [2Fe-2S] cluster binding site [ion binding]; other site 1009846011534 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1009846011535 hydrophobic ligand binding site; other site 1009846011536 short chain dehydrogenase; Provisional; Region: PRK12939 1009846011537 classical (c) SDRs; Region: SDR_c; cd05233 1009846011538 NAD(P) binding site [chemical binding]; other site 1009846011539 active site 1009846011540 Cupin domain; Region: Cupin_2; pfam07883 1009846011541 Serine hydrolase; Region: Ser_hydrolase; cl17834 1009846011542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846011543 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846011544 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846011545 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846011546 short chain dehydrogenase; Provisional; Region: PRK07062 1009846011547 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1009846011548 putative NAD(P) binding site [chemical binding]; other site 1009846011549 putative active site [active] 1009846011550 hypothetical protein; Provisional; Region: PRK07064 1009846011551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846011552 PYR/PP interface [polypeptide binding]; other site 1009846011553 dimer interface [polypeptide binding]; other site 1009846011554 TPP binding site [chemical binding]; other site 1009846011555 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846011556 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1009846011557 TPP-binding site [chemical binding]; other site 1009846011558 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1009846011559 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1009846011560 Domain of unknown function DUF108; Region: DUF108; pfam01958 1009846011561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846011562 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1009846011563 NAD(P) binding site [chemical binding]; other site 1009846011564 catalytic residues [active] 1009846011565 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846011566 active site 1009846011567 metal binding site [ion binding]; metal-binding site 1009846011568 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1009846011569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846011570 putative active site [active] 1009846011571 putative metal binding site [ion binding]; other site 1009846011572 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1009846011573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846011574 benzoate transport; Region: 2A0115; TIGR00895 1009846011575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011576 putative substrate translocation pore; other site 1009846011577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011578 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009846011579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846011580 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1009846011581 hybrid cluster protein; Provisional; Region: PRK05290 1009846011582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1009846011583 ACS interaction site; other site 1009846011584 CODH interaction site; other site 1009846011585 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1009846011586 hybrid metal cluster; other site 1009846011587 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1009846011588 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846011589 catalytic loop [active] 1009846011590 iron binding site [ion binding]; other site 1009846011591 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1009846011592 FAD binding pocket [chemical binding]; other site 1009846011593 conserved FAD binding motif [chemical binding]; other site 1009846011594 phosphate binding motif [ion binding]; other site 1009846011595 beta-alpha-beta structure motif; other site 1009846011596 NAD binding pocket [chemical binding]; other site 1009846011597 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1009846011598 trimer interface [polypeptide binding]; other site 1009846011599 putative Zn binding site [ion binding]; other site 1009846011600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846011601 TPR motif; other site 1009846011602 binding surface 1009846011603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846011604 Ligand Binding Site [chemical binding]; other site 1009846011605 amidase; Provisional; Region: PRK07486 1009846011606 Amidase; Region: Amidase; cl11426 1009846011607 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1009846011608 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1009846011609 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1009846011610 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1009846011611 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 1009846011612 active site 1 [active] 1009846011613 dimer interface [polypeptide binding]; other site 1009846011614 hexamer interface [polypeptide binding]; other site 1009846011615 active site 2 [active] 1009846011616 aldolase II superfamily protein; Provisional; Region: PRK07044 1009846011617 intersubunit interface [polypeptide binding]; other site 1009846011618 active site 1009846011619 Zn2+ binding site [ion binding]; other site 1009846011620 Urea transporter; Region: UT; cl01829 1009846011621 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1009846011622 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846011623 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846011624 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1009846011625 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1009846011626 short chain dehydrogenase; Provisional; Region: PRK07832 1009846011627 classical (c) SDRs; Region: SDR_c; cd05233 1009846011628 NAD(P) binding site [chemical binding]; other site 1009846011629 active site 1009846011630 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1009846011631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1009846011632 YhhN-like protein; Region: YhhN; pfam07947 1009846011633 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1009846011634 oligomer interface [polypeptide binding]; other site 1009846011635 putative active site [active] 1009846011636 Mn binding site [ion binding]; other site 1009846011637 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1009846011638 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1009846011639 HSP70 interaction site [polypeptide binding]; other site 1009846011640 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009846011641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846011642 substrate binding pocket [chemical binding]; other site 1009846011643 membrane-bound complex binding site; other site 1009846011644 hinge residues; other site 1009846011645 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1009846011646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1009846011647 DNA binding residues [nucleotide binding] 1009846011648 putative dimer interface [polypeptide binding]; other site 1009846011649 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1009846011650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846011651 Coenzyme A binding pocket [chemical binding]; other site 1009846011652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011655 dimerization interface [polypeptide binding]; other site 1009846011656 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1009846011657 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1009846011658 NADP binding site [chemical binding]; other site 1009846011659 dimer interface [polypeptide binding]; other site 1009846011660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011662 putative substrate translocation pore; other site 1009846011663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011664 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1009846011665 Tar ligand binding domain homologue; Region: TarH; pfam02203 1009846011666 dimer interface [polypeptide binding]; other site 1009846011667 ligand binding site [chemical binding]; other site 1009846011668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846011669 dimerization interface [polypeptide binding]; other site 1009846011670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846011671 dimer interface [polypeptide binding]; other site 1009846011672 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1009846011673 putative CheW interface [polypeptide binding]; other site 1009846011674 Part of AAA domain; Region: AAA_19; pfam13245 1009846011675 Family description; Region: UvrD_C_2; pfam13538 1009846011676 BetR domain; Region: BetR; pfam08667 1009846011677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1009846011678 active site 1009846011679 phosphorylation site [posttranslational modification] 1009846011680 intermolecular recognition site; other site 1009846011681 dimerization interface [polypeptide binding]; other site 1009846011682 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846011683 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846011684 Ion channel; Region: Ion_trans_2; pfam07885 1009846011685 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1009846011686 TrkA-N domain; Region: TrkA_N; pfam02254 1009846011687 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1009846011688 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1009846011689 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1009846011690 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1009846011691 shikimate binding site; other site 1009846011692 NAD(P) binding site [chemical binding]; other site 1009846011693 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1009846011694 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846011695 TM-ABC transporter signature motif; other site 1009846011696 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846011697 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846011698 Walker A/P-loop; other site 1009846011699 ATP binding site [chemical binding]; other site 1009846011700 Q-loop/lid; other site 1009846011701 ABC transporter signature motif; other site 1009846011702 Walker B; other site 1009846011703 D-loop; other site 1009846011704 H-loop/switch region; other site 1009846011705 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846011706 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846011707 Walker A/P-loop; other site 1009846011708 ATP binding site [chemical binding]; other site 1009846011709 Q-loop/lid; other site 1009846011710 ABC transporter signature motif; other site 1009846011711 Walker B; other site 1009846011712 D-loop; other site 1009846011713 H-loop/switch region; other site 1009846011714 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846011715 TM-ABC transporter signature motif; other site 1009846011716 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1009846011717 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009846011718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846011719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846011720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1009846011721 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846011722 extended (e) SDRs; Region: SDR_e; cd08946 1009846011723 NAD(P) binding site [chemical binding]; other site 1009846011724 active site 1009846011725 substrate binding site [chemical binding]; other site 1009846011726 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1009846011727 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1009846011728 NIPSNAP; Region: NIPSNAP; pfam07978 1009846011729 NIPSNAP; Region: NIPSNAP; pfam07978 1009846011730 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1009846011731 benzoate transport; Region: 2A0115; TIGR00895 1009846011732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011733 putative substrate translocation pore; other site 1009846011734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011735 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846011736 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846011737 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846011738 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1009846011739 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846011740 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846011741 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846011742 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846011743 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846011744 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846011745 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1009846011746 Cache domain; Region: Cache_1; pfam02743 1009846011747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846011748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846011749 metal binding site [ion binding]; metal-binding site 1009846011750 active site 1009846011751 I-site; other site 1009846011752 Cupin domain; Region: Cupin_2; pfam07883 1009846011753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846011754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846011755 H-NS histone family; Region: Histone_HNS; pfam00816 1009846011756 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1009846011757 classical (c) SDRs; Region: SDR_c; cd05233 1009846011758 NAD(P) binding site [chemical binding]; other site 1009846011759 active site 1009846011760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011762 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1009846011763 substrate binding pocket [chemical binding]; other site 1009846011764 dimerization interface [polypeptide binding]; other site 1009846011765 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846011766 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1009846011767 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1009846011768 active site 1009846011769 non-prolyl cis peptide bond; other site 1009846011770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846011771 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1009846011772 active site 1009846011773 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1009846011774 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1009846011775 Flavin binding site [chemical binding]; other site 1009846011776 Predicted esterase [General function prediction only]; Region: COG0627 1009846011777 S-formylglutathione hydrolase; Region: PLN02442 1009846011778 OpgC protein; Region: OpgC_C; pfam10129 1009846011779 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846011780 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846011781 trimer interface [polypeptide binding]; other site 1009846011782 eyelet of channel; other site 1009846011783 transcriptional regulator; Provisional; Region: PRK10632 1009846011784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011785 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846011786 putative effector binding pocket; other site 1009846011787 putative dimerization interface [polypeptide binding]; other site 1009846011788 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846011789 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846011790 active site 1009846011791 catalytic tetrad [active] 1009846011792 Predicted ester cyclase [General function prediction only]; Region: COG5485 1009846011793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011795 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1009846011796 putative dimerization interface [polypeptide binding]; other site 1009846011797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846011798 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009846011799 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1009846011800 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846011801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011802 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846011803 substrate binding pocket [chemical binding]; other site 1009846011804 dimerization interface [polypeptide binding]; other site 1009846011805 Predicted membrane protein [Function unknown]; Region: COG2261 1009846011806 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846011807 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1009846011808 PapC N-terminal domain; Region: PapC_N; pfam13954 1009846011809 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1009846011810 PapC C-terminal domain; Region: PapC_C; pfam13953 1009846011811 putative chaperone protein EcpD; Provisional; Region: PRK09926 1009846011812 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1009846011813 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1009846011814 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1009846011815 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1009846011816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846011817 Walker A/P-loop; other site 1009846011818 ATP binding site [chemical binding]; other site 1009846011819 Q-loop/lid; other site 1009846011820 ABC transporter signature motif; other site 1009846011821 Walker B; other site 1009846011822 D-loop; other site 1009846011823 H-loop/switch region; other site 1009846011824 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1009846011825 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846011826 Walker A/P-loop; other site 1009846011827 ATP binding site [chemical binding]; other site 1009846011828 Q-loop/lid; other site 1009846011829 ABC transporter signature motif; other site 1009846011830 Walker B; other site 1009846011831 D-loop; other site 1009846011832 H-loop/switch region; other site 1009846011833 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1009846011834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011835 dimer interface [polypeptide binding]; other site 1009846011836 conserved gate region; other site 1009846011837 putative PBP binding loops; other site 1009846011838 ABC-ATPase subunit interface; other site 1009846011839 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1009846011840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846011841 dimer interface [polypeptide binding]; other site 1009846011842 conserved gate region; other site 1009846011843 putative PBP binding loops; other site 1009846011844 ABC-ATPase subunit interface; other site 1009846011845 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1009846011846 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1009846011847 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1009846011848 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1009846011849 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1009846011850 putative molybdopterin cofactor binding site [chemical binding]; other site 1009846011851 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1009846011852 putative molybdopterin cofactor binding site; other site 1009846011853 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846011854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846011855 DNA-binding site [nucleotide binding]; DNA binding site 1009846011856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846011857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846011858 homodimer interface [polypeptide binding]; other site 1009846011859 catalytic residue [active] 1009846011860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846011861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846011862 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1009846011863 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1009846011864 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1009846011865 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1009846011866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011869 dimerization interface [polypeptide binding]; other site 1009846011870 LysE type translocator; Region: LysE; cl00565 1009846011871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011872 putative substrate translocation pore; other site 1009846011873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011874 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846011875 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1009846011876 catalytic triad [active] 1009846011877 conserved cis-peptide bond; other site 1009846011878 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846011879 MarR family; Region: MarR; pfam01047 1009846011880 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1009846011881 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1009846011882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1009846011883 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846011884 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846011885 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1009846011886 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1009846011887 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1009846011888 PAAR motif; Region: PAAR_motif; pfam05488 1009846011889 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1009846011890 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1009846011891 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846011892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011893 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846011894 dimerization interface [polypeptide binding]; other site 1009846011895 substrate binding pocket [chemical binding]; other site 1009846011896 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1009846011897 magnesium-transporting ATPase; Provisional; Region: PRK15122 1009846011898 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1009846011899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009846011900 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1009846011901 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1009846011902 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1009846011903 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1009846011904 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1009846011905 active site 1009846011906 catalytic triad [active] 1009846011907 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1009846011908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846011909 substrate binding pocket [chemical binding]; other site 1009846011910 membrane-bound complex binding site; other site 1009846011911 hinge residues; other site 1009846011912 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1009846011913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011914 putative substrate translocation pore; other site 1009846011915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846011916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846011917 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1009846011918 Transglycosylase; Region: Transgly; pfam00912 1009846011919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009846011920 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1009846011921 Bacterial Ig-like domain; Region: Big_5; pfam13205 1009846011922 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1009846011923 MG2 domain; Region: A2M_N; pfam01835 1009846011924 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1009846011925 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1009846011926 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846011927 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846011928 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846011929 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846011930 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846011931 Predicted membrane protein [Function unknown]; Region: COG2259 1009846011932 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846011933 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846011934 trimer interface [polypeptide binding]; other site 1009846011935 eyelet of channel; other site 1009846011936 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846011937 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846011938 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1009846011939 metal binding site [ion binding]; metal-binding site 1009846011940 putative dimer interface [polypeptide binding]; other site 1009846011941 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1009846011942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011944 dimerization interface [polypeptide binding]; other site 1009846011945 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1009846011946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1009846011947 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1009846011948 Cl- selectivity filter; other site 1009846011949 Cl- binding residues [ion binding]; other site 1009846011950 pore gating glutamate residue; other site 1009846011951 dimer interface [polypeptide binding]; other site 1009846011952 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1009846011953 FOG: CBS domain [General function prediction only]; Region: COG0517 1009846011954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1009846011955 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846011956 MarR family; Region: MarR_2; pfam12802 1009846011957 MarR family; Region: MarR_2; cl17246 1009846011958 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1009846011959 HPP family; Region: HPP; pfam04982 1009846011960 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1009846011961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846011962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846011964 putative effector binding pocket; other site 1009846011965 dimerization interface [polypeptide binding]; other site 1009846011966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846011967 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846011968 putative substrate translocation pore; other site 1009846011969 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1009846011970 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1009846011971 putative ligand binding site [chemical binding]; other site 1009846011972 NAD binding site [chemical binding]; other site 1009846011973 catalytic site [active] 1009846011974 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846011975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846011976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846011977 dimerization interface [polypeptide binding]; other site 1009846011978 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1009846011979 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1009846011980 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1009846011981 DctM-like transporters; Region: DctM; pfam06808 1009846011982 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1009846011983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846011984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846011985 DNA binding site [nucleotide binding] 1009846011986 domain linker motif; other site 1009846011987 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009846011988 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1009846011989 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1009846011990 NAD binding site [chemical binding]; other site 1009846011991 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1009846011992 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1009846011993 active site 1009846011994 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1009846011995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846011996 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846011997 substrate binding pocket [chemical binding]; other site 1009846011998 membrane-bound complex binding site; other site 1009846011999 hinge residues; other site 1009846012000 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846012001 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1009846012002 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1009846012003 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846012004 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846012005 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846012006 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1009846012007 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1009846012008 active site 1009846012009 AMP binding site [chemical binding]; other site 1009846012010 homodimer interface [polypeptide binding]; other site 1009846012011 acyl-activating enzyme (AAE) consensus motif; other site 1009846012012 CoA binding site [chemical binding]; other site 1009846012013 enoyl-CoA hydratase; Provisional; Region: PRK05995 1009846012014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846012015 substrate binding site [chemical binding]; other site 1009846012016 oxyanion hole (OAH) forming residues; other site 1009846012017 trimer interface [polypeptide binding]; other site 1009846012018 MarC family integral membrane protein; Region: MarC; cl00919 1009846012019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846012020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846012021 active site 1009846012022 catalytic tetrad [active] 1009846012023 CAAX protease self-immunity; Region: Abi; pfam02517 1009846012024 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1009846012025 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1009846012026 putative NAD(P) binding site [chemical binding]; other site 1009846012027 catalytic Zn binding site [ion binding]; other site 1009846012028 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1009846012029 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1009846012030 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846012031 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846012032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846012033 DNA-binding site [nucleotide binding]; DNA binding site 1009846012034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846012035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846012036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846012037 homodimer interface [polypeptide binding]; other site 1009846012038 catalytic residue [active] 1009846012039 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846012040 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1009846012041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846012043 putative substrate translocation pore; other site 1009846012044 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846012045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846012046 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1009846012047 putative dimerization interface [polypeptide binding]; other site 1009846012048 putative substrate binding pocket [chemical binding]; other site 1009846012049 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1009846012050 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1009846012051 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846012052 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1009846012053 protein binding site [polypeptide binding]; other site 1009846012054 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846012055 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846012056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846012057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846012058 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1009846012059 putative uracil binding site [chemical binding]; other site 1009846012060 putative active site [active] 1009846012061 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1009846012062 NMT1-like family; Region: NMT1_2; pfam13379 1009846012063 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1009846012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012065 active site 1009846012066 phosphorylation site [posttranslational modification] 1009846012067 intermolecular recognition site; other site 1009846012068 dimerization interface [polypeptide binding]; other site 1009846012069 ANTAR domain; Region: ANTAR; pfam03861 1009846012070 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1009846012071 active site 1009846012072 SAM binding site [chemical binding]; other site 1009846012073 homodimer interface [polypeptide binding]; other site 1009846012074 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1009846012075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012076 putative substrate translocation pore; other site 1009846012077 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1009846012078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846012079 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1009846012080 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846012081 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1009846012082 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1009846012083 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1009846012084 [4Fe-4S] binding site [ion binding]; other site 1009846012085 molybdopterin cofactor binding site; other site 1009846012086 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1009846012087 molybdopterin cofactor binding site; other site 1009846012088 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1009846012089 Flavodoxin; Region: Flavodoxin_1; pfam00258 1009846012090 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1009846012091 FAD binding pocket [chemical binding]; other site 1009846012092 FAD binding motif [chemical binding]; other site 1009846012093 catalytic residues [active] 1009846012094 NAD binding pocket [chemical binding]; other site 1009846012095 phosphate binding motif [ion binding]; other site 1009846012096 beta-alpha-beta structure motif; other site 1009846012097 short chain dehydrogenase; Provisional; Region: PRK09291 1009846012098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846012099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846012100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846012101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846012102 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1009846012103 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1009846012104 putative active site [active] 1009846012105 putative FMN binding site [chemical binding]; other site 1009846012106 putative substrate binding site [chemical binding]; other site 1009846012107 putative catalytic residue [active] 1009846012108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846012109 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1009846012110 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1009846012111 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1009846012112 active site 1009846012113 ornithine cyclodeaminase; Validated; Region: PRK06141 1009846012114 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846012115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846012116 MarR family; Region: MarR_2; pfam12802 1009846012117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846012118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846012119 Walker A/P-loop; other site 1009846012120 ATP binding site [chemical binding]; other site 1009846012121 Q-loop/lid; other site 1009846012122 ABC transporter signature motif; other site 1009846012123 Walker B; other site 1009846012124 D-loop; other site 1009846012125 H-loop/switch region; other site 1009846012126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846012127 dimer interface [polypeptide binding]; other site 1009846012128 conserved gate region; other site 1009846012129 putative PBP binding loops; other site 1009846012130 ABC-ATPase subunit interface; other site 1009846012131 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846012132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846012133 dimer interface [polypeptide binding]; other site 1009846012134 conserved gate region; other site 1009846012135 putative PBP binding loops; other site 1009846012136 ABC-ATPase subunit interface; other site 1009846012137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846012138 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846012139 substrate binding pocket [chemical binding]; other site 1009846012140 membrane-bound complex binding site; other site 1009846012141 hinge residues; other site 1009846012142 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846012143 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846012144 trimer interface [polypeptide binding]; other site 1009846012145 eyelet of channel; other site 1009846012146 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1009846012147 Ligand binding site [chemical binding]; other site 1009846012148 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1009846012149 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1009846012150 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1009846012151 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1009846012152 Predicted integral membrane protein [Function unknown]; Region: COG0392 1009846012153 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1009846012154 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1009846012155 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1009846012156 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1009846012157 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1009846012158 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1009846012159 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846012160 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846012161 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846012162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846012163 DNA-binding site [nucleotide binding]; DNA binding site 1009846012164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846012165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846012166 homodimer interface [polypeptide binding]; other site 1009846012167 catalytic residue [active] 1009846012168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012169 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846012170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846012171 DNA-binding site [nucleotide binding]; DNA binding site 1009846012172 FCD domain; Region: FCD; pfam07729 1009846012173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012174 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1009846012175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012176 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1009846012177 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1009846012178 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1009846012179 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846012180 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009846012181 inhibitor site; inhibition site 1009846012182 active site 1009846012183 dimer interface [polypeptide binding]; other site 1009846012184 catalytic residue [active] 1009846012185 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846012186 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1009846012187 dimer interface [polypeptide binding]; other site 1009846012188 NADP binding site [chemical binding]; other site 1009846012189 catalytic residues [active] 1009846012190 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846012191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846012192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846012193 dimerization interface [polypeptide binding]; other site 1009846012194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846012195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846012196 metal binding site [ion binding]; metal-binding site 1009846012197 active site 1009846012198 I-site; other site 1009846012199 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846012200 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1009846012201 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1009846012202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846012203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846012204 dimerization interface [polypeptide binding]; other site 1009846012205 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846012206 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1009846012207 active site 1009846012208 metal binding site [ion binding]; metal-binding site 1009846012209 RNA polymerase sigma factor; Reviewed; Region: PRK05602 1009846012210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846012211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846012212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1009846012213 Probable transposase; Region: OrfB_IS605; pfam01385 1009846012214 Heavy-metal resistance; Region: Metal_resist; pfam13801 1009846012215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846012216 Coenzyme A binding pocket [chemical binding]; other site 1009846012217 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1009846012218 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1009846012219 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1009846012220 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1009846012221 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846012222 C-terminal domain interface [polypeptide binding]; other site 1009846012223 GSH binding site (G-site) [chemical binding]; other site 1009846012224 dimer interface [polypeptide binding]; other site 1009846012225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 1009846012226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1009846012227 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1009846012228 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 1009846012229 Int/Topo IB signature motif; other site 1009846012230 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1009846012231 dimerization interface [polypeptide binding]; other site 1009846012232 DNA binding residues [nucleotide binding] 1009846012233 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1009846012234 putative transporter; Provisional; Region: PRK10504 1009846012235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012236 putative substrate translocation pore; other site 1009846012237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846012239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846012240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846012241 dimerization interface [polypeptide binding]; other site 1009846012242 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846012243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1009846012244 active site 1009846012245 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1009846012246 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1009846012247 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1009846012248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846012249 Flavin binding site [chemical binding]; other site 1009846012250 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1009846012251 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1009846012252 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1009846012253 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1009846012254 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1009846012255 FAD binding pocket [chemical binding]; other site 1009846012256 FAD binding motif [chemical binding]; other site 1009846012257 phosphate binding motif [ion binding]; other site 1009846012258 beta-alpha-beta structure motif; other site 1009846012259 NAD(p) ribose binding residues [chemical binding]; other site 1009846012260 NAD binding pocket [chemical binding]; other site 1009846012261 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1009846012262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846012263 catalytic loop [active] 1009846012264 iron binding site [ion binding]; other site 1009846012265 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1009846012266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846012267 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1009846012268 acyl-activating enzyme (AAE) consensus motif; other site 1009846012269 putative AMP binding site [chemical binding]; other site 1009846012270 putative active site [active] 1009846012271 putative CoA binding site [chemical binding]; other site 1009846012272 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1009846012273 classical (c) SDRs; Region: SDR_c; cd05233 1009846012274 NAD(P) binding site [chemical binding]; other site 1009846012275 active site 1009846012276 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1009846012277 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009846012278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1009846012279 active site 1009846012280 DNA binding site [nucleotide binding] 1009846012281 Int/Topo IB signature motif; other site 1009846012282 Excisionase-like protein; Region: Exc; pfam07825 1009846012283 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1009846012284 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1009846012285 Active Sites [active] 1009846012286 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1009846012287 Restriction endonuclease; Region: Mrr_cat; pfam04471 1009846012288 hypothetical protein; Region: PHA01769 1009846012289 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 1009846012290 Helix-turn-helix domain; Region: HTH_36; pfam13730 1009846012291 Phage endonuclease I; Region: Phage_endo_I; cl11622 1009846012292 MarR family; Region: MarR_2; cl17246 1009846012293 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1009846012294 aconitate hydratase-like protein; Provisional; Region: PTZ00092 1009846012295 Ion channel; Region: Ion_trans_2; pfam07885 1009846012296 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1009846012297 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1009846012298 active site 1009846012299 phage terminase, small subunit, putative, P27 family; Region: sm_term_P27; TIGR01558 1009846012300 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1009846012301 Phage portal protein; Region: Phage_portal; pfam04860 1009846012302 Phage-related protein [Function unknown]; Region: COG4695 1009846012303 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1009846012304 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1009846012305 tandem repeat interface [polypeptide binding]; other site 1009846012306 oligomer interface [polypeptide binding]; other site 1009846012307 active site residues [active] 1009846012308 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1009846012309 Phage capsid family; Region: Phage_capsid; pfam05065 1009846012310 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 1009846012311 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1009846012312 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1009846012313 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1009846012314 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1009846012315 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1009846012316 Phage-related minor tail protein [Function unknown]; Region: COG5281 1009846012317 tape measure domain; Region: tape_meas_nterm; TIGR02675 1009846012318 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1009846012319 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1009846012320 Phage-related protein [Function unknown]; Region: gp18; COG4672 1009846012321 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1009846012322 MPN+ (JAMM) motif; other site 1009846012323 Zinc-binding site [ion binding]; other site 1009846012324 NlpC/P60 family; Region: NLPC_P60; cl17555 1009846012325 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1009846012326 Phage-related protein, tail component [Function unknown]; Region: COG4723 1009846012327 Phage-related protein, tail component [Function unknown]; Region: COG4733 1009846012328 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1009846012329 Fibronectin type 3 domain; Region: FN3; smart00060 1009846012330 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1009846012331 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 1009846012332 Phage holin family 2; Region: Phage_holin_2; pfam04550 1009846012333 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1009846012334 catalytic residue [active] 1009846012335 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1009846012336 active site 1009846012337 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1009846012338 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1009846012339 SEC-C motif; Region: SEC-C; pfam02810 1009846012340 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1009846012341 HNH endonuclease; Region: HNH_2; pfam13391 1009846012342 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1009846012343 oligomeric interface; other site 1009846012344 putative active site [active] 1009846012345 homodimer interface [polypeptide binding]; other site 1009846012346 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1009846012347 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1009846012348 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1009846012349 active site 1009846012350 Fe binding site [ion binding]; other site 1009846012351 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1009846012352 Coenzyme A transferase; Region: CoA_trans; cl17247 1009846012353 enoyl-CoA hydratase; Provisional; Region: PRK08290 1009846012354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846012355 substrate binding site [chemical binding]; other site 1009846012356 oxyanion hole (OAH) forming residues; other site 1009846012357 trimer interface [polypeptide binding]; other site 1009846012358 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1009846012359 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846012360 FMN binding site [chemical binding]; other site 1009846012361 substrate binding site [chemical binding]; other site 1009846012362 putative catalytic residue [active] 1009846012363 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846012364 enoyl-CoA hydratase; Provisional; Region: PRK06495 1009846012365 substrate binding site [chemical binding]; other site 1009846012366 oxyanion hole (OAH) forming residues; other site 1009846012367 trimer interface [polypeptide binding]; other site 1009846012368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846012369 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1009846012370 FAD binding site [chemical binding]; other site 1009846012371 substrate binding site [chemical binding]; other site 1009846012372 catalytic base [active] 1009846012373 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1009846012374 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1009846012375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846012376 active site 1009846012377 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1009846012378 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846012379 dimer interface [polypeptide binding]; other site 1009846012380 active site 1009846012381 short chain dehydrogenase; Provisional; Region: PRK07791 1009846012382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012383 NAD(P) binding site [chemical binding]; other site 1009846012384 active site 1009846012385 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846012386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846012387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846012388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846012389 active site 1009846012390 short chain dehydrogenase; Provisional; Region: PRK07831 1009846012391 classical (c) SDRs; Region: SDR_c; cd05233 1009846012392 NAD(P) binding site [chemical binding]; other site 1009846012393 active site 1009846012394 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1009846012395 putative active site [active] 1009846012396 putative catalytic site [active] 1009846012397 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1009846012398 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846012399 dimer interface [polypeptide binding]; other site 1009846012400 active site 1009846012401 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1009846012402 Protein export membrane protein; Region: SecD_SecF; cl14618 1009846012403 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846012404 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1009846012405 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846012406 DNA-binding site [nucleotide binding]; DNA binding site 1009846012407 RNA-binding motif; other site 1009846012408 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1009846012409 rRNA binding site [nucleotide binding]; other site 1009846012410 predicted 30S ribosome binding site; other site 1009846012411 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1009846012412 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1009846012413 Phasin protein; Region: Phasin_2; pfam09361 1009846012414 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1009846012415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846012416 DNA binding residues [nucleotide binding] 1009846012417 dimerization interface [polypeptide binding]; other site 1009846012418 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846012419 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1009846012420 iron-sulfur cluster [ion binding]; other site 1009846012421 [2Fe-2S] cluster binding site [ion binding]; other site 1009846012422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012423 classical (c) SDRs; Region: SDR_c; cd05233 1009846012424 NAD(P) binding site [chemical binding]; other site 1009846012425 active site 1009846012426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012427 classical (c) SDRs; Region: SDR_c; cd05233 1009846012428 NAD(P) binding site [chemical binding]; other site 1009846012429 active site 1009846012430 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1009846012431 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846012432 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846012433 FMN binding site [chemical binding]; other site 1009846012434 active site 1009846012435 substrate binding site [chemical binding]; other site 1009846012436 catalytic residue [active] 1009846012437 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1009846012438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846012439 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846012440 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1009846012441 acyl-activating enzyme (AAE) consensus motif; other site 1009846012442 acyl-activating enzyme (AAE) consensus motif; other site 1009846012443 putative AMP binding site [chemical binding]; other site 1009846012444 putative active site [active] 1009846012445 putative CoA binding site [chemical binding]; other site 1009846012446 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012447 classical (c) SDRs; Region: SDR_c; cd05233 1009846012448 NAD(P) binding site [chemical binding]; other site 1009846012449 active site 1009846012450 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1009846012451 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1009846012452 active site 1009846012453 catalytic residues [active] 1009846012454 metal binding site [ion binding]; metal-binding site 1009846012455 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1009846012456 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1009846012457 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009846012458 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1009846012459 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1009846012460 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1009846012461 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1009846012462 short chain dehydrogenase; Provisional; Region: PRK07856 1009846012463 classical (c) SDRs; Region: SDR_c; cd05233 1009846012464 NAD(P) binding site [chemical binding]; other site 1009846012465 active site 1009846012466 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1009846012467 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1009846012468 short chain dehydrogenase; Provisional; Region: PRK06114 1009846012469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012470 NAD(P) binding site [chemical binding]; other site 1009846012471 active site 1009846012472 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1009846012473 Ligand binding site [chemical binding]; other site 1009846012474 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1009846012475 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1009846012476 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1009846012477 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1009846012478 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1009846012479 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1009846012480 putative trimer interface [polypeptide binding]; other site 1009846012481 putative CoA binding site [chemical binding]; other site 1009846012482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846012484 putative substrate translocation pore; other site 1009846012485 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 1009846012486 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1009846012487 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1009846012488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846012489 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1009846012490 dimer interface [polypeptide binding]; other site 1009846012491 putative metal binding site [ion binding]; other site 1009846012492 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846012493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846012494 putative DNA binding site [nucleotide binding]; other site 1009846012495 putative Zn2+ binding site [ion binding]; other site 1009846012496 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846012497 LysE type translocator; Region: LysE; pfam01810 1009846012498 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1009846012499 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846012500 N-terminal plug; other site 1009846012501 ligand-binding site [chemical binding]; other site 1009846012502 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846012503 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846012504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846012505 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1009846012506 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1009846012507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846012508 putative NAD(P) binding site [chemical binding]; other site 1009846012509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012510 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1009846012511 NAD(P) binding site [chemical binding]; other site 1009846012512 active site 1009846012513 hypothetical protein; Provisional; Region: PRK06194 1009846012514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012515 NAD(P) binding site [chemical binding]; other site 1009846012516 active site 1009846012517 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1009846012518 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1009846012519 tetramer interface [polypeptide binding]; other site 1009846012520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846012521 catalytic residue [active] 1009846012522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1009846012523 YheO-like PAS domain; Region: PAS_6; pfam08348 1009846012524 HTH domain; Region: HTH_22; pfam13309 1009846012525 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1009846012526 putative deacylase active site [active] 1009846012527 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1009846012528 tetramer interface [polypeptide binding]; other site 1009846012529 active site 1009846012530 Mg2+/Mn2+ binding site [ion binding]; other site 1009846012531 isocitrate lyase; Region: PLN02892 1009846012532 EthD domain; Region: EthD; pfam07110 1009846012533 SnoaL-like domain; Region: SnoaL_4; pfam13577 1009846012534 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1009846012535 short chain dehydrogenase; Provisional; Region: PRK08303 1009846012536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012537 NAD(P) binding site [chemical binding]; other site 1009846012538 active site 1009846012539 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1009846012540 classical (c) SDRs; Region: SDR_c; cd05233 1009846012541 NAD(P) binding site [chemical binding]; other site 1009846012542 active site 1009846012543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012545 NAD(P) binding site [chemical binding]; other site 1009846012546 active site 1009846012547 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1009846012548 active site 1009846012549 substrate-binding site [chemical binding]; other site 1009846012550 metal-binding site [ion binding] 1009846012551 GTP binding site [chemical binding]; other site 1009846012552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012553 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1009846012554 NAD(P) binding site [chemical binding]; other site 1009846012555 active site 1009846012556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012557 classical (c) SDRs; Region: SDR_c; cd05233 1009846012558 NAD(P) binding site [chemical binding]; other site 1009846012559 active site 1009846012560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846012561 short chain dehydrogenase; Validated; Region: PRK07069 1009846012562 NAD(P) binding site [chemical binding]; other site 1009846012563 active site 1009846012564 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846012565 classical (c) SDRs; Region: SDR_c; cd05233 1009846012566 NAD(P) binding site [chemical binding]; other site 1009846012567 active site 1009846012568 SnoaL-like domain; Region: SnoaL_4; pfam13577 1009846012569 hypothetical protein; Validated; Region: PRK07121 1009846012570 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1009846012571 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1009846012572 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1009846012573 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1009846012574 FtsH Extracellular; Region: FtsH_ext; pfam06480 1009846012575 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1009846012576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846012577 Walker A motif; other site 1009846012578 ATP binding site [chemical binding]; other site 1009846012579 Walker B motif; other site 1009846012580 arginine finger; other site 1009846012581 Peptidase family M41; Region: Peptidase_M41; pfam01434 1009846012582 OsmC-like protein; Region: OsmC; pfam02566 1009846012583 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1009846012584 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1009846012585 active site 1009846012586 homotetramer interface [polypeptide binding]; other site 1009846012587 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1009846012588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846012589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846012590 dimer interface [polypeptide binding]; other site 1009846012591 putative CheW interface [polypeptide binding]; other site 1009846012592 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1009846012593 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846012594 N-terminal plug; other site 1009846012595 ligand-binding site [chemical binding]; other site 1009846012596 BNR repeat-like domain; Region: BNR_2; pfam13088 1009846012597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846012598 MarR family; Region: MarR; pfam01047 1009846012599 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1009846012600 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1009846012601 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1009846012602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846012603 substrate binding pocket [chemical binding]; other site 1009846012604 membrane-bound complex binding site; other site 1009846012605 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1009846012606 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1009846012607 dimer interface [polypeptide binding]; other site 1009846012608 active site 1009846012609 non-prolyl cis peptide bond; other site 1009846012610 insertion regions; other site 1009846012611 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846012612 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846012613 substrate binding pocket [chemical binding]; other site 1009846012614 membrane-bound complex binding site; other site 1009846012615 hinge residues; other site 1009846012616 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846012617 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1009846012618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846012619 putative PBP binding loops; other site 1009846012620 dimer interface [polypeptide binding]; other site 1009846012621 ABC-ATPase subunit interface; other site 1009846012622 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846012623 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846012624 Walker A/P-loop; other site 1009846012625 ATP binding site [chemical binding]; other site 1009846012626 Q-loop/lid; other site 1009846012627 ABC transporter signature motif; other site 1009846012628 Walker B; other site 1009846012629 D-loop; other site 1009846012630 H-loop/switch region; other site 1009846012631 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1009846012632 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1009846012633 active site 1009846012634 non-prolyl cis peptide bond; other site 1009846012635 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1009846012636 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1009846012637 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1009846012638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846012639 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846012640 substrate binding pocket [chemical binding]; other site 1009846012641 membrane-bound complex binding site; other site 1009846012642 hinge residues; other site 1009846012643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1009846012644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846012645 Coenzyme A binding pocket [chemical binding]; other site 1009846012646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846012647 AAA domain; Region: AAA_21; pfam13304 1009846012648 Walker A/P-loop; other site 1009846012649 ATP binding site [chemical binding]; other site 1009846012650 Q-loop/lid; other site 1009846012651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846012652 Walker B; other site 1009846012653 D-loop; other site 1009846012654 H-loop/switch region; other site 1009846012655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846012656 AAA domain; Region: AAA_23; pfam13476 1009846012657 AAA domain; Region: AAA_21; pfam13304 1009846012658 Walker A/P-loop; other site 1009846012659 ATP binding site [chemical binding]; other site 1009846012660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1009846012661 ABC transporter signature motif; other site 1009846012662 Walker B; other site 1009846012663 D-loop; other site 1009846012664 H-loop/switch region; other site 1009846012665 Patatin-like phospholipase; Region: Patatin; pfam01734 1009846012666 active site 1009846012667 nucleophile elbow; other site 1009846012668 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1009846012669 toxin interface [polypeptide binding]; other site 1009846012670 Zn binding site [ion binding]; other site 1009846012671 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1009846012672 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1009846012673 putative active site [active] 1009846012674 Zn binding site [ion binding]; other site 1009846012675 PAS fold; Region: PAS_7; pfam12860 1009846012676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846012677 putative active site [active] 1009846012678 heme pocket [chemical binding]; other site 1009846012679 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846012680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846012681 metal binding site [ion binding]; metal-binding site 1009846012682 active site 1009846012683 I-site; other site 1009846012684 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1009846012685 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846012686 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1009846012687 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846012688 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1009846012689 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1009846012690 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846012691 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846012692 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1009846012693 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1009846012694 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846012695 ligand binding site [chemical binding]; other site 1009846012696 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846012697 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846012698 trimer interface [polypeptide binding]; other site 1009846012699 eyelet of channel; other site 1009846012700 threonine dehydratase; Reviewed; Region: PRK09224 1009846012701 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1009846012702 tetramer interface [polypeptide binding]; other site 1009846012703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846012704 catalytic residue [active] 1009846012705 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1009846012706 putative Ile/Val binding site [chemical binding]; other site 1009846012707 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1009846012708 putative Ile/Val binding site [chemical binding]; other site 1009846012709 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1009846012710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846012711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012712 active site 1009846012713 phosphorylation site [posttranslational modification] 1009846012714 intermolecular recognition site; other site 1009846012715 dimerization interface [polypeptide binding]; other site 1009846012716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846012717 DNA binding residues [nucleotide binding] 1009846012718 dimerization interface [polypeptide binding]; other site 1009846012719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846012720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846012721 dimer interface [polypeptide binding]; other site 1009846012722 phosphorylation site [posttranslational modification] 1009846012723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846012724 ATP binding site [chemical binding]; other site 1009846012725 Mg2+ binding site [ion binding]; other site 1009846012726 G-X-G motif; other site 1009846012727 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846012728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012729 active site 1009846012730 phosphorylation site [posttranslational modification] 1009846012731 intermolecular recognition site; other site 1009846012732 dimerization interface [polypeptide binding]; other site 1009846012733 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1009846012734 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1009846012735 Beta-lactamase; Region: Beta-lactamase; pfam00144 1009846012736 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1009846012737 Beta-lactamase; Region: Beta-lactamase; pfam00144 1009846012738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1009846012739 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1009846012740 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1009846012741 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1009846012742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012743 putative substrate translocation pore; other site 1009846012744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846012745 transcriptional activator TtdR; Provisional; Region: PRK09801 1009846012746 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1009846012747 putative effector binding pocket; other site 1009846012748 putative dimerization interface [polypeptide binding]; other site 1009846012749 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846012750 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1009846012751 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846012752 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846012753 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1009846012754 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1009846012755 tetramer interface [polypeptide binding]; other site 1009846012756 heme binding pocket [chemical binding]; other site 1009846012757 Helix-turn-helix domain; Region: HTH_28; pfam13518 1009846012758 Winged helix-turn helix; Region: HTH_29; pfam13551 1009846012759 Homeodomain-like domain; Region: HTH_32; pfam13565 1009846012760 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1009846012761 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012762 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012763 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012764 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012765 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012766 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012767 RHS Repeat; Region: RHS_repeat; cl11982 1009846012768 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1009846012769 RHS Repeat; Region: RHS_repeat; pfam05593 1009846012770 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1009846012771 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1009846012772 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1009846012773 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1009846012774 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1009846012775 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1009846012776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846012777 Walker A motif; other site 1009846012778 ATP binding site [chemical binding]; other site 1009846012779 Walker B motif; other site 1009846012780 arginine finger; other site 1009846012781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846012782 Walker A motif; other site 1009846012783 ATP binding site [chemical binding]; other site 1009846012784 Walker B motif; other site 1009846012785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1009846012786 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1009846012787 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1009846012788 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1009846012789 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1009846012790 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1009846012791 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1009846012792 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1009846012793 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1009846012794 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1009846012795 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1009846012796 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1009846012797 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1009846012798 active site 1009846012799 ATP binding site [chemical binding]; other site 1009846012800 substrate binding site [chemical binding]; other site 1009846012801 activation loop (A-loop); other site 1009846012802 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1009846012803 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1009846012804 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1009846012805 G1 box; other site 1009846012806 GTP/Mg2+ binding site [chemical binding]; other site 1009846012807 G2 box; other site 1009846012808 G3 box; other site 1009846012809 Switch II region; other site 1009846012810 G4 box; other site 1009846012811 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1009846012812 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1009846012813 hypothetical protein; Provisional; Region: PRK07033 1009846012814 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1009846012815 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846012816 ligand binding site [chemical binding]; other site 1009846012817 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1009846012818 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1009846012819 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1009846012820 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1009846012821 phosphopeptide binding site; other site 1009846012822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846012823 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1009846012824 tetramerization interface [polypeptide binding]; other site 1009846012825 NAD(P) binding site [chemical binding]; other site 1009846012826 catalytic residues [active] 1009846012827 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846012828 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1009846012829 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846012830 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846012831 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1009846012832 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1009846012833 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846012834 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1009846012835 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1009846012836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846012837 catalytic loop [active] 1009846012838 iron binding site [ion binding]; other site 1009846012839 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1009846012840 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1009846012841 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1009846012842 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1009846012843 NAD(P) binding site [chemical binding]; other site 1009846012844 substrate binding site [chemical binding]; other site 1009846012845 dimer interface [polypeptide binding]; other site 1009846012846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846012847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846012848 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1009846012849 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1009846012850 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846012851 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846012852 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846012853 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1009846012854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1009846012855 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1009846012856 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846012857 substrate binding pocket [chemical binding]; other site 1009846012858 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1009846012859 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1009846012860 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1009846012861 dimerization interface [polypeptide binding]; other site 1009846012862 active site 1009846012863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846012864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846012865 salt bridge; other site 1009846012866 non-specific DNA binding site [nucleotide binding]; other site 1009846012867 sequence-specific DNA binding site [nucleotide binding]; other site 1009846012868 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1009846012869 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1009846012870 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1009846012871 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1009846012872 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846012873 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1009846012874 active site 1009846012875 FMN binding site [chemical binding]; other site 1009846012876 substrate binding site [chemical binding]; other site 1009846012877 putative catalytic residue [active] 1009846012878 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1009846012879 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1009846012880 dimer interface [polypeptide binding]; other site 1009846012881 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1009846012882 active site 1009846012883 Fe binding site [ion binding]; other site 1009846012884 shikimate transporter; Provisional; Region: PRK09952 1009846012885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846012886 putative substrate translocation pore; other site 1009846012887 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1009846012888 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1009846012889 putative active site [active] 1009846012890 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 1009846012891 putative active site [active] 1009846012892 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1009846012893 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1009846012894 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1009846012895 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846012896 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1009846012897 DEAD_2; Region: DEAD_2; pfam06733 1009846012898 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1009846012899 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1009846012900 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1009846012901 FOG: CBS domain [General function prediction only]; Region: COG0517 1009846012902 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1009846012903 PRC-barrel domain; Region: PRC; pfam05239 1009846012904 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1009846012905 PAS fold; Region: PAS; pfam00989 1009846012906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846012907 putative active site [active] 1009846012908 heme pocket [chemical binding]; other site 1009846012909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846012910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846012911 dimer interface [polypeptide binding]; other site 1009846012912 phosphorylation site [posttranslational modification] 1009846012913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846012914 ATP binding site [chemical binding]; other site 1009846012915 Mg2+ binding site [ion binding]; other site 1009846012916 G-X-G motif; other site 1009846012917 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846012918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012919 active site 1009846012920 phosphorylation site [posttranslational modification] 1009846012921 intermolecular recognition site; other site 1009846012922 dimerization interface [polypeptide binding]; other site 1009846012923 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1009846012924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846012925 Walker A motif; other site 1009846012926 ATP binding site [chemical binding]; other site 1009846012927 Walker B motif; other site 1009846012928 arginine finger; other site 1009846012929 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846012930 Cache domain; Region: Cache_1; pfam02743 1009846012931 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1009846012932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846012933 dimerization interface [polypeptide binding]; other site 1009846012934 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846012935 dimer interface [polypeptide binding]; other site 1009846012936 putative CheW interface [polypeptide binding]; other site 1009846012937 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 1009846012938 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846012939 Ligand Binding Site [chemical binding]; other site 1009846012940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846012941 Ligand Binding Site [chemical binding]; other site 1009846012942 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009846012943 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1009846012944 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1009846012945 active site residue [active] 1009846012946 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1009846012947 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846012948 Ligand Binding Site [chemical binding]; other site 1009846012949 PAS domain S-box; Region: sensory_box; TIGR00229 1009846012950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846012951 putative active site [active] 1009846012952 heme pocket [chemical binding]; other site 1009846012953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1009846012954 Histidine kinase; Region: HisKA_3; pfam07730 1009846012955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846012956 ATP binding site [chemical binding]; other site 1009846012957 Mg2+ binding site [ion binding]; other site 1009846012958 G-X-G motif; other site 1009846012959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846012960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012961 active site 1009846012962 phosphorylation site [posttranslational modification] 1009846012963 intermolecular recognition site; other site 1009846012964 dimerization interface [polypeptide binding]; other site 1009846012965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846012966 DNA binding residues [nucleotide binding] 1009846012967 dimerization interface [polypeptide binding]; other site 1009846012968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1009846012969 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 1009846012970 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 1009846012971 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1009846012972 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846012973 PilZ domain; Region: PilZ; pfam07238 1009846012974 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1009846012975 Transglycosylase; Region: Transgly; pfam00912 1009846012976 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009846012977 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1009846012978 Proline racemase; Region: Pro_racemase; pfam05544 1009846012979 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846012980 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846012981 dimerization interface [polypeptide binding]; other site 1009846012982 ligand binding site [chemical binding]; other site 1009846012983 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1009846012984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846012985 DNA-binding site [nucleotide binding]; DNA binding site 1009846012986 FCD domain; Region: FCD; pfam07729 1009846012987 ornithine cyclodeaminase; Validated; Region: PRK07340 1009846012988 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846012989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846012990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846012991 active site 1009846012992 phosphorylation site [posttranslational modification] 1009846012993 intermolecular recognition site; other site 1009846012994 dimerization interface [polypeptide binding]; other site 1009846012995 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1009846012996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846012997 ligand binding site [chemical binding]; other site 1009846012998 flexible hinge region; other site 1009846012999 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009846013000 putative switch regulator; other site 1009846013001 non-specific DNA interactions [nucleotide binding]; other site 1009846013002 DNA binding site [nucleotide binding] 1009846013003 sequence specific DNA binding site [nucleotide binding]; other site 1009846013004 putative cAMP binding site [chemical binding]; other site 1009846013005 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1009846013006 Protein of unknown function, DUF488; Region: DUF488; cl01246 1009846013007 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1009846013008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846013009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013010 homodimer interface [polypeptide binding]; other site 1009846013011 catalytic residue [active] 1009846013012 aromatic amino acid transporter; Provisional; Region: PRK10238 1009846013013 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846013014 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1009846013015 putative DNA binding site [nucleotide binding]; other site 1009846013016 putative Zn2+ binding site [ion binding]; other site 1009846013017 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846013018 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1009846013019 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1009846013020 EamA-like transporter family; Region: EamA; cl17759 1009846013021 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1009846013022 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1009846013023 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 1009846013024 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1009846013025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846013026 S-adenosylmethionine binding site [chemical binding]; other site 1009846013027 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 1009846013028 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1009846013029 putative ion selectivity filter; other site 1009846013030 putative pore gating glutamate residue; other site 1009846013031 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1009846013032 cytosine deaminase; Provisional; Region: PRK09230 1009846013033 active site 1009846013034 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1009846013035 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846013036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846013037 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846013038 trimer interface [polypeptide binding]; other site 1009846013039 eyelet of channel; other site 1009846013040 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846013041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846013042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013043 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846013044 putative effector binding pocket; other site 1009846013045 dimerization interface [polypeptide binding]; other site 1009846013046 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1009846013047 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846013048 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1009846013049 homodimer interface [polypeptide binding]; other site 1009846013050 homotetramer interface [polypeptide binding]; other site 1009846013051 active site pocket [active] 1009846013052 cleavage site 1009846013053 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846013054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846013055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846013056 DNA binding residues [nucleotide binding] 1009846013057 dimerization interface [polypeptide binding]; other site 1009846013058 Cytochrome P450; Region: p450; cl12078 1009846013059 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1009846013060 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846013061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013062 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846013063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846013064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013065 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1009846013066 putative dimerization interface [polypeptide binding]; other site 1009846013067 Predicted permeases [General function prediction only]; Region: COG0679 1009846013068 EamA-like transporter family; Region: EamA; cl17759 1009846013069 EamA-like transporter family; Region: EamA; pfam00892 1009846013070 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846013071 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846013072 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1009846013073 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1009846013074 tetrameric interface [polypeptide binding]; other site 1009846013075 NAD binding site [chemical binding]; other site 1009846013076 catalytic residues [active] 1009846013077 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1009846013078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846013079 inhibitor-cofactor binding pocket; inhibition site 1009846013080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013081 catalytic residue [active] 1009846013082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846013083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846013085 dimerization interface [polypeptide binding]; other site 1009846013086 H+ Antiporter protein; Region: 2A0121; TIGR00900 1009846013087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013088 putative substrate translocation pore; other site 1009846013089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846013090 MarR family; Region: MarR_2; cl17246 1009846013091 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1009846013092 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846013093 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846013094 conserved cys residue [active] 1009846013095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013096 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1009846013097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846013098 NAD(P) binding site [chemical binding]; other site 1009846013099 active site 1009846013100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846013101 PAS fold; Region: PAS_3; pfam08447 1009846013102 putative active site [active] 1009846013103 heme pocket [chemical binding]; other site 1009846013104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846013105 PAS fold; Region: PAS_3; pfam08447 1009846013106 putative active site [active] 1009846013107 heme pocket [chemical binding]; other site 1009846013108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846013109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846013110 metal binding site [ion binding]; metal-binding site 1009846013111 active site 1009846013112 I-site; other site 1009846013113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013114 putative substrate translocation pore; other site 1009846013115 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1009846013116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013117 putative substrate translocation pore; other site 1009846013118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1009846013119 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846013120 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846013121 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846013122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846013123 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1009846013124 putative DNA binding site [nucleotide binding]; other site 1009846013125 putative Zn2+ binding site [ion binding]; other site 1009846013126 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846013127 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846013128 voltage-gated potassium channel; Provisional; Region: PRK10537 1009846013129 Ion channel; Region: Ion_trans_2; pfam07885 1009846013130 TrkA-N domain; Region: TrkA_N; pfam02254 1009846013131 Predicted membrane protein [Function unknown]; Region: COG1238 1009846013132 acyl-CoA synthetase; Validated; Region: PRK08162 1009846013133 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1009846013134 acyl-activating enzyme (AAE) consensus motif; other site 1009846013135 putative active site [active] 1009846013136 AMP binding site [chemical binding]; other site 1009846013137 putative CoA binding site [chemical binding]; other site 1009846013138 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009846013139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846013140 ligand binding site [chemical binding]; other site 1009846013141 flexible hinge region; other site 1009846013142 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1009846013143 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1009846013144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846013145 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846013146 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846013147 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1009846013148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846013149 active site 1009846013150 phosphorylation site [posttranslational modification] 1009846013151 intermolecular recognition site; other site 1009846013152 dimerization interface [polypeptide binding]; other site 1009846013153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846013154 DNA binding site [nucleotide binding] 1009846013155 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1009846013156 HAMP domain; Region: HAMP; pfam00672 1009846013157 dimerization interface [polypeptide binding]; other site 1009846013158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846013159 dimer interface [polypeptide binding]; other site 1009846013160 phosphorylation site [posttranslational modification] 1009846013161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846013162 ATP binding site [chemical binding]; other site 1009846013163 Mg2+ binding site [ion binding]; other site 1009846013164 G-X-G motif; other site 1009846013165 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846013166 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846013167 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846013168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013170 short chain dehydrogenase; Provisional; Region: PRK06523 1009846013171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846013172 NAD(P) binding site [chemical binding]; other site 1009846013173 active site 1009846013174 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1009846013175 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1009846013176 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1009846013177 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846013178 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1009846013179 active site 1009846013180 FMN binding site [chemical binding]; other site 1009846013181 substrate binding site [chemical binding]; other site 1009846013182 homotetramer interface [polypeptide binding]; other site 1009846013183 catalytic residue [active] 1009846013184 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1009846013185 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1009846013186 potential catalytic triad [active] 1009846013187 conserved cys residue [active] 1009846013188 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846013189 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846013190 DNA binding site [nucleotide binding] 1009846013191 domain linker motif; other site 1009846013192 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1009846013193 ligand binding site [chemical binding]; other site 1009846013194 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1009846013195 active site 1009846013196 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1009846013197 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1009846013198 substrate binding [chemical binding]; other site 1009846013199 active site 1009846013200 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1009846013201 short chain dehydrogenase; Provisional; Region: PRK06500 1009846013202 classical (c) SDRs; Region: SDR_c; cd05233 1009846013203 NAD(P) binding site [chemical binding]; other site 1009846013204 active site 1009846013205 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1009846013206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846013208 dimerization interface [polypeptide binding]; other site 1009846013209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846013210 DNA-binding site [nucleotide binding]; DNA binding site 1009846013211 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846013212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846013213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013214 homodimer interface [polypeptide binding]; other site 1009846013215 catalytic residue [active] 1009846013216 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846013217 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1009846013218 Cupin domain; Region: Cupin_2; pfam07883 1009846013219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846013220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846013221 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1009846013222 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846013223 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1009846013224 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1009846013225 Walker A/P-loop; other site 1009846013226 ATP binding site [chemical binding]; other site 1009846013227 Q-loop/lid; other site 1009846013228 ABC transporter signature motif; other site 1009846013229 Walker B; other site 1009846013230 D-loop; other site 1009846013231 H-loop/switch region; other site 1009846013232 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1009846013233 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1009846013234 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1009846013235 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1009846013236 Outer membrane efflux protein; Region: OEP; pfam02321 1009846013237 Outer membrane efflux protein; Region: OEP; pfam02321 1009846013238 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846013239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846013240 trimer interface [polypeptide binding]; other site 1009846013241 eyelet of channel; other site 1009846013242 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1009846013243 active site lid residues [active] 1009846013244 substrate binding pocket [chemical binding]; other site 1009846013245 catalytic residues [active] 1009846013246 substrate-Mg2+ binding site; other site 1009846013247 aspartate-rich region 1; other site 1009846013248 aspartate-rich region 2; other site 1009846013249 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1009846013250 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 1009846013251 active site residue [active] 1009846013252 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1009846013253 active site residue [active] 1009846013254 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1009846013255 active site residue [active] 1009846013256 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1009846013257 active site residue [active] 1009846013258 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1009846013259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846013260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846013262 dimerization interface [polypeptide binding]; other site 1009846013263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846013264 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1009846013265 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1009846013266 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1009846013267 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1009846013268 dimer interface [polypeptide binding]; other site 1009846013269 active site 1009846013270 non-prolyl cis peptide bond; other site 1009846013271 insertion regions; other site 1009846013272 hypothetical protein; Provisional; Region: PRK06208 1009846013273 active site 1009846013274 intersubunit interface [polypeptide binding]; other site 1009846013275 Zn2+ binding site [ion binding]; other site 1009846013276 NMT1-like family; Region: NMT1_2; pfam13379 1009846013277 NMT1/THI5 like; Region: NMT1; pfam09084 1009846013278 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846013279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013280 dimer interface [polypeptide binding]; other site 1009846013281 conserved gate region; other site 1009846013282 putative PBP binding loops; other site 1009846013283 ABC-ATPase subunit interface; other site 1009846013284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009846013285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846013286 Walker A/P-loop; other site 1009846013287 ATP binding site [chemical binding]; other site 1009846013288 Q-loop/lid; other site 1009846013289 ABC transporter signature motif; other site 1009846013290 Walker B; other site 1009846013291 D-loop; other site 1009846013292 H-loop/switch region; other site 1009846013293 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846013294 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846013295 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009846013296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846013297 membrane-bound complex binding site; other site 1009846013298 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1009846013299 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1009846013300 MOSC domain; Region: MOSC; pfam03473 1009846013301 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1009846013302 HAMP domain; Region: HAMP; pfam00672 1009846013303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846013304 dimer interface [polypeptide binding]; other site 1009846013305 phosphorylation site [posttranslational modification] 1009846013306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846013307 ATP binding site [chemical binding]; other site 1009846013308 Mg2+ binding site [ion binding]; other site 1009846013309 G-X-G motif; other site 1009846013310 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1009846013311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846013312 active site 1009846013313 phosphorylation site [posttranslational modification] 1009846013314 intermolecular recognition site; other site 1009846013315 dimerization interface [polypeptide binding]; other site 1009846013316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846013317 DNA binding site [nucleotide binding] 1009846013318 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846013319 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846013320 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1009846013321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013322 dimer interface [polypeptide binding]; other site 1009846013323 conserved gate region; other site 1009846013324 ABC-ATPase subunit interface; other site 1009846013325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013326 dimer interface [polypeptide binding]; other site 1009846013327 conserved gate region; other site 1009846013328 putative PBP binding loops; other site 1009846013329 ABC-ATPase subunit interface; other site 1009846013330 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1009846013331 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846013332 Walker A/P-loop; other site 1009846013333 ATP binding site [chemical binding]; other site 1009846013334 Q-loop/lid; other site 1009846013335 ABC transporter signature motif; other site 1009846013336 Walker B; other site 1009846013337 D-loop; other site 1009846013338 H-loop/switch region; other site 1009846013339 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846013340 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846013341 trimer interface [polypeptide binding]; other site 1009846013342 eyelet of channel; other site 1009846013343 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846013344 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846013345 NAD(P) binding site [chemical binding]; other site 1009846013346 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846013347 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846013348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013349 PIN domain; Region: PIN_3; pfam13470 1009846013350 DNA binding domain, excisionase family; Region: excise; TIGR01764 1009846013351 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1009846013352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1009846013353 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1009846013354 putative substrate binding pocket [chemical binding]; other site 1009846013355 trimer interface [polypeptide binding]; other site 1009846013356 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1009846013357 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1009846013358 putative active site [active] 1009846013359 putative metal binding site [ion binding]; other site 1009846013360 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1009846013361 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1009846013362 NAD binding site [chemical binding]; other site 1009846013363 catalytic residues [active] 1009846013364 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1009846013365 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846013366 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1009846013367 MarR family; Region: MarR_2; cl17246 1009846013368 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846013369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846013370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846013371 NAD(P) binding site [chemical binding]; other site 1009846013372 active site 1009846013373 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 1009846013374 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1009846013375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1009846013376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1009846013377 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1009846013378 putative cation:proton antiport protein; Provisional; Region: PRK10669 1009846013379 TrkA-N domain; Region: TrkA_N; pfam02254 1009846013380 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846013381 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846013382 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846013383 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846013384 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846013385 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846013386 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1009846013387 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1009846013388 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1009846013389 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1009846013390 hexamer interface [polypeptide binding]; other site 1009846013391 ligand binding site [chemical binding]; other site 1009846013392 putative active site [active] 1009846013393 NAD(P) binding site [chemical binding]; other site 1009846013394 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1009846013395 hypothetical protein; Provisional; Region: PRK08609 1009846013396 active site 1009846013397 primer binding site [nucleotide binding]; other site 1009846013398 NTP binding site [chemical binding]; other site 1009846013399 metal binding triad [ion binding]; metal-binding site 1009846013400 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1009846013401 active site 1009846013402 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1009846013403 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1009846013404 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1009846013405 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009846013406 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009846013407 non-specific DNA interactions [nucleotide binding]; other site 1009846013408 DNA binding site [nucleotide binding] 1009846013409 sequence specific DNA binding site [nucleotide binding]; other site 1009846013410 putative cAMP binding site [chemical binding]; other site 1009846013411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009846013412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846013413 ligand binding site [chemical binding]; other site 1009846013414 flexible hinge region; other site 1009846013415 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1009846013416 acyl carrier protein; Provisional; Region: PRK07081 1009846013417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846013418 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1009846013419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846013420 active site 1009846013421 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 1009846013422 dimer interface [polypeptide binding]; other site 1009846013423 motif 1; other site 1009846013424 active site 1009846013425 motif 2; other site 1009846013426 motif 3; other site 1009846013427 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 1009846013428 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1009846013429 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846013430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846013431 Walker A motif; other site 1009846013432 ATP binding site [chemical binding]; other site 1009846013433 Walker B motif; other site 1009846013434 arginine finger; other site 1009846013435 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846013436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846013437 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1009846013438 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1009846013439 Substrate binding site; other site 1009846013440 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1009846013441 Right handed beta helix region; Region: Beta_helix; pfam13229 1009846013442 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1009846013443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1009846013444 active site 1009846013445 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1009846013446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846013447 putative ADP-binding pocket [chemical binding]; other site 1009846013448 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1009846013449 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1009846013450 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1009846013451 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1009846013452 tyrosine kinase; Provisional; Region: PRK11519 1009846013453 Chain length determinant protein; Region: Wzz; pfam02706 1009846013454 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1009846013455 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1009846013456 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1009846013457 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1009846013458 SLBB domain; Region: SLBB; pfam10531 1009846013459 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 1009846013460 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1009846013461 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1009846013462 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1009846013463 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1009846013464 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1009846013465 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1009846013466 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1009846013467 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1009846013468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846013469 FeS/SAM binding site; other site 1009846013470 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1009846013471 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1009846013472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846013473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013474 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846013475 putative effector binding pocket; other site 1009846013476 dimerization interface [polypeptide binding]; other site 1009846013477 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846013478 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846013479 trimer interface [polypeptide binding]; other site 1009846013480 eyelet of channel; other site 1009846013481 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1009846013482 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1009846013483 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1009846013484 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1009846013485 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1009846013486 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1009846013487 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1009846013488 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1009846013489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1009846013490 ATP binding site [chemical binding]; other site 1009846013491 putative Mg++ binding site [ion binding]; other site 1009846013492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846013493 nucleotide binding region [chemical binding]; other site 1009846013494 ATP-binding site [chemical binding]; other site 1009846013495 DEAD/H associated; Region: DEAD_assoc; pfam08494 1009846013496 putative transporter; Provisional; Region: PRK11021 1009846013497 putative transporter; Provisional; Region: PRK11021 1009846013498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009846013499 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1009846013500 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1009846013501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846013503 dimerization interface [polypeptide binding]; other site 1009846013504 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1009846013505 heterodimer interface [polypeptide binding]; other site 1009846013506 multimer interface [polypeptide binding]; other site 1009846013507 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1009846013508 active site 1009846013509 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1009846013510 heterodimer interface [polypeptide binding]; other site 1009846013511 active site 1009846013512 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846013513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846013514 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846013515 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846013516 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1009846013517 SxDxEG motif; other site 1009846013518 active site 1009846013519 metal binding site [ion binding]; metal-binding site 1009846013520 homopentamer interface [polypeptide binding]; other site 1009846013521 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1009846013522 homodimer interface [polypeptide binding]; other site 1009846013523 homotetramer interface [polypeptide binding]; other site 1009846013524 active site pocket [active] 1009846013525 cleavage site 1009846013526 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1009846013527 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1009846013528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013529 dimer interface [polypeptide binding]; other site 1009846013530 conserved gate region; other site 1009846013531 putative PBP binding loops; other site 1009846013532 ABC-ATPase subunit interface; other site 1009846013533 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1009846013534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013535 dimer interface [polypeptide binding]; other site 1009846013536 conserved gate region; other site 1009846013537 putative PBP binding loops; other site 1009846013538 ABC-ATPase subunit interface; other site 1009846013539 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1009846013540 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1009846013541 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1009846013542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846013543 Walker A/P-loop; other site 1009846013544 ATP binding site [chemical binding]; other site 1009846013545 Q-loop/lid; other site 1009846013546 ABC transporter signature motif; other site 1009846013547 Walker B; other site 1009846013548 D-loop; other site 1009846013549 H-loop/switch region; other site 1009846013550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846013551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846013552 Walker A/P-loop; other site 1009846013553 ATP binding site [chemical binding]; other site 1009846013554 Q-loop/lid; other site 1009846013555 ABC transporter signature motif; other site 1009846013556 Walker B; other site 1009846013557 D-loop; other site 1009846013558 H-loop/switch region; other site 1009846013559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1009846013560 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1009846013561 catalytic nucleophile [active] 1009846013562 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1009846013563 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1009846013564 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1009846013565 putative active site [active] 1009846013566 BCCT family transporter; Region: BCCT; cl00569 1009846013567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846013568 S-adenosylmethionine binding site [chemical binding]; other site 1009846013569 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1009846013570 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1009846013571 active site 1009846013572 metal binding site [ion binding]; metal-binding site 1009846013573 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1009846013574 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846013575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846013576 DNA-binding site [nucleotide binding]; DNA binding site 1009846013577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846013578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013579 homodimer interface [polypeptide binding]; other site 1009846013580 catalytic residue [active] 1009846013581 Predicted transporter component [General function prediction only]; Region: COG2391 1009846013582 Sulphur transport; Region: Sulf_transp; pfam04143 1009846013583 Predicted transporter component [General function prediction only]; Region: COG2391 1009846013584 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1009846013585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846013586 dimerization interface [polypeptide binding]; other site 1009846013587 putative DNA binding site [nucleotide binding]; other site 1009846013588 putative Zn2+ binding site [ion binding]; other site 1009846013589 benzoate transport; Region: 2A0115; TIGR00895 1009846013590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013591 putative substrate translocation pore; other site 1009846013592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013593 salicylate hydroxylase; Provisional; Region: PRK08163 1009846013594 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846013595 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1009846013596 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1009846013597 C-terminal domain interface [polypeptide binding]; other site 1009846013598 GSH binding site (G-site) [chemical binding]; other site 1009846013599 putative dimer interface [polypeptide binding]; other site 1009846013600 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1009846013601 dimer interface [polypeptide binding]; other site 1009846013602 N-terminal domain interface [polypeptide binding]; other site 1009846013603 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1009846013604 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846013605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846013606 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1009846013607 Cupin domain; Region: Cupin_2; pfam07883 1009846013608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846013610 dimerization interface [polypeptide binding]; other site 1009846013611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1009846013612 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1009846013613 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846013614 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846013615 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1009846013616 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1009846013617 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846013618 Spore germination protein; Region: Spore_permease; cl17796 1009846013619 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846013620 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1009846013621 dimer interface [polypeptide binding]; other site 1009846013622 NADP binding site [chemical binding]; other site 1009846013623 catalytic residues [active] 1009846013624 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1009846013625 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1009846013626 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1009846013627 Bacterial SH3 domain; Region: SH3_3; pfam08239 1009846013628 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1009846013629 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1009846013630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846013631 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1009846013632 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1009846013633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846013634 DNA binding residues [nucleotide binding] 1009846013635 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1009846013636 metal binding triad [ion binding]; metal-binding site 1009846013637 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1009846013638 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1009846013639 DNA binding residues [nucleotide binding] 1009846013640 putative dimer interface [polypeptide binding]; other site 1009846013641 putative metal binding residues [ion binding]; other site 1009846013642 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 1009846013643 MarR family; Region: MarR_2; cl17246 1009846013644 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846013645 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846013646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846013647 putative substrate translocation pore; other site 1009846013648 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1009846013649 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1009846013650 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1009846013651 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1009846013652 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1009846013653 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1009846013654 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1009846013655 active site 1009846013656 metal-binding site 1009846013657 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1009846013658 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1009846013659 tetramer interface [polypeptide binding]; other site 1009846013660 active site 1009846013661 Mg2+/Mn2+ binding site [ion binding]; other site 1009846013662 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1009846013663 active site 1009846013664 metal-binding site 1009846013665 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846013666 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1009846013667 PYR/PP interface [polypeptide binding]; other site 1009846013668 dimer interface [polypeptide binding]; other site 1009846013669 TPP binding site [chemical binding]; other site 1009846013670 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1009846013671 TPP-binding site [chemical binding]; other site 1009846013672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846013673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846013674 catalytic residue [active] 1009846013675 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1009846013676 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009846013677 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1009846013678 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1009846013679 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1009846013680 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1009846013681 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1009846013682 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1009846013683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1009846013684 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1009846013685 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1009846013686 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1009846013687 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1009846013688 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1009846013689 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1009846013690 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1009846013691 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1009846013692 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1009846013693 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1009846013694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1009846013695 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1009846013696 cell density-dependent motility repressor; Provisional; Region: PRK10082 1009846013697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846013699 dimerization interface [polypeptide binding]; other site 1009846013700 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1009846013701 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1009846013702 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1009846013703 putative active site [active] 1009846013704 putative metal binding site [ion binding]; other site 1009846013705 N-glycosyltransferase; Provisional; Region: PRK11204 1009846013706 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1009846013707 DXD motif; other site 1009846013708 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1009846013709 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1009846013710 glutaminase active site [active] 1009846013711 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009846013712 dimer interface [polypeptide binding]; other site 1009846013713 active site 1009846013714 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009846013715 dimer interface [polypeptide binding]; other site 1009846013716 active site 1009846013717 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1009846013718 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846013719 allantoate amidohydrolase; Reviewed; Region: PRK12891 1009846013720 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1009846013721 active site 1009846013722 metal binding site [ion binding]; metal-binding site 1009846013723 dimer interface [polypeptide binding]; other site 1009846013724 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1009846013725 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846013726 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846013727 dimerization interface [polypeptide binding]; other site 1009846013728 ligand binding site [chemical binding]; other site 1009846013729 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846013730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013731 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846013732 dimerization interface [polypeptide binding]; other site 1009846013733 substrate binding pocket [chemical binding]; other site 1009846013734 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1009846013735 oligomeric interface; other site 1009846013736 putative active site [active] 1009846013737 homodimer interface [polypeptide binding]; other site 1009846013738 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1009846013739 aspartate racemase; Region: asp_race; TIGR00035 1009846013740 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846013741 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1009846013742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846013743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846013744 substrate binding pocket [chemical binding]; other site 1009846013745 membrane-bound complex binding site; other site 1009846013746 hinge residues; other site 1009846013747 peroxiredoxin; Region: AhpC; TIGR03137 1009846013748 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1009846013749 dimer interface [polypeptide binding]; other site 1009846013750 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1009846013751 catalytic triad [active] 1009846013752 peroxidatic and resolving cysteines [active] 1009846013753 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1009846013754 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1009846013755 catalytic residue [active] 1009846013756 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1009846013757 catalytic residues [active] 1009846013758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846013759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846013760 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1009846013761 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1009846013762 hypothetical protein; Provisional; Region: PRK07483 1009846013763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846013764 inhibitor-cofactor binding pocket; inhibition site 1009846013765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013766 catalytic residue [active] 1009846013767 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1009846013768 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1009846013769 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846013770 Walker A/P-loop; other site 1009846013771 ATP binding site [chemical binding]; other site 1009846013772 Q-loop/lid; other site 1009846013773 ABC transporter signature motif; other site 1009846013774 Walker B; other site 1009846013775 D-loop; other site 1009846013776 H-loop/switch region; other site 1009846013777 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846013778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013779 dimer interface [polypeptide binding]; other site 1009846013780 conserved gate region; other site 1009846013781 putative PBP binding loops; other site 1009846013782 ABC-ATPase subunit interface; other site 1009846013783 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1009846013784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846013785 substrate binding pocket [chemical binding]; other site 1009846013786 membrane-bound complex binding site; other site 1009846013787 hinge residues; other site 1009846013788 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1009846013789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846013790 Walker A/P-loop; other site 1009846013791 ATP binding site [chemical binding]; other site 1009846013792 Q-loop/lid; other site 1009846013793 ABC transporter signature motif; other site 1009846013794 Walker B; other site 1009846013795 D-loop; other site 1009846013796 H-loop/switch region; other site 1009846013797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846013798 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1009846013799 Walker A/P-loop; other site 1009846013800 ATP binding site [chemical binding]; other site 1009846013801 Q-loop/lid; other site 1009846013802 ABC transporter signature motif; other site 1009846013803 Walker B; other site 1009846013804 D-loop; other site 1009846013805 H-loop/switch region; other site 1009846013806 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1009846013807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846013809 dimerization interface [polypeptide binding]; other site 1009846013810 MAPEG family; Region: MAPEG; cl09190 1009846013811 alanine racemase; Reviewed; Region: PRK13340 1009846013812 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1009846013813 active site 1009846013814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846013815 substrate binding site [chemical binding]; other site 1009846013816 catalytic residues [active] 1009846013817 dimer interface [polypeptide binding]; other site 1009846013818 enoyl-CoA hydratase; Validated; Region: PRK08139 1009846013819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846013820 substrate binding site [chemical binding]; other site 1009846013821 oxyanion hole (OAH) forming residues; other site 1009846013822 trimer interface [polypeptide binding]; other site 1009846013823 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846013824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846013825 active site 1009846013826 phosphorylation site [posttranslational modification] 1009846013827 intermolecular recognition site; other site 1009846013828 dimerization interface [polypeptide binding]; other site 1009846013829 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1009846013830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846013831 putative CheW interface [polypeptide binding]; other site 1009846013832 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1009846013833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846013834 dimerization interface [polypeptide binding]; other site 1009846013835 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1009846013836 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1009846013837 putative binding surface; other site 1009846013838 active site 1009846013839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846013840 ATP binding site [chemical binding]; other site 1009846013841 Mg2+ binding site [ion binding]; other site 1009846013842 G-X-G motif; other site 1009846013843 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1009846013844 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1009846013845 active site 1009846013846 Zn binding site [ion binding]; other site 1009846013847 aspartate aminotransferase; Provisional; Region: PRK05764 1009846013848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846013849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846013850 homodimer interface [polypeptide binding]; other site 1009846013851 catalytic residue [active] 1009846013852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013853 dimer interface [polypeptide binding]; other site 1009846013854 conserved gate region; other site 1009846013855 putative PBP binding loops; other site 1009846013856 ABC-ATPase subunit interface; other site 1009846013857 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846013858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013859 dimer interface [polypeptide binding]; other site 1009846013860 conserved gate region; other site 1009846013861 putative PBP binding loops; other site 1009846013862 ABC-ATPase subunit interface; other site 1009846013863 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846013864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846013865 substrate binding pocket [chemical binding]; other site 1009846013866 membrane-bound complex binding site; other site 1009846013867 hinge residues; other site 1009846013868 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1009846013869 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846013870 Walker A/P-loop; other site 1009846013871 ATP binding site [chemical binding]; other site 1009846013872 Q-loop/lid; other site 1009846013873 ABC transporter signature motif; other site 1009846013874 Walker B; other site 1009846013875 D-loop; other site 1009846013876 H-loop/switch region; other site 1009846013877 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1009846013878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846013879 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1009846013880 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846013881 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1009846013882 PYR/PP interface [polypeptide binding]; other site 1009846013883 dimer interface [polypeptide binding]; other site 1009846013884 TPP binding site [chemical binding]; other site 1009846013885 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846013886 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1009846013887 TPP-binding site [chemical binding]; other site 1009846013888 MarC family integral membrane protein; Region: MarC; cl00919 1009846013889 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1009846013890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846013891 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846013892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013893 dimer interface [polypeptide binding]; other site 1009846013894 conserved gate region; other site 1009846013895 putative PBP binding loops; other site 1009846013896 ABC-ATPase subunit interface; other site 1009846013897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846013898 dimer interface [polypeptide binding]; other site 1009846013899 conserved gate region; other site 1009846013900 putative PBP binding loops; other site 1009846013901 ABC-ATPase subunit interface; other site 1009846013902 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846013903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846013904 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846013905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846013906 Walker A/P-loop; other site 1009846013907 ATP binding site [chemical binding]; other site 1009846013908 Q-loop/lid; other site 1009846013909 ABC transporter signature motif; other site 1009846013910 Walker B; other site 1009846013911 D-loop; other site 1009846013912 H-loop/switch region; other site 1009846013913 TOBE domain; Region: TOBE_2; pfam08402 1009846013914 enoyl-CoA hydratase; Provisional; Region: PRK06688 1009846013915 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846013916 substrate binding site [chemical binding]; other site 1009846013917 oxyanion hole (OAH) forming residues; other site 1009846013918 trimer interface [polypeptide binding]; other site 1009846013919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846013920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846013921 active site 1009846013922 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1009846013923 CoA binding domain; Region: CoA_binding_2; pfam13380 1009846013924 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1009846013925 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1009846013926 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1009846013927 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846013928 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846013929 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846013930 trimer interface [polypeptide binding]; other site 1009846013931 eyelet of channel; other site 1009846013932 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1009846013933 active site 1009846013934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846013935 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1009846013936 NAD(P) binding site [chemical binding]; other site 1009846013937 catalytic residues [active] 1009846013938 putative hydrolase; Provisional; Region: PRK11460 1009846013939 L-asparagine permease; Provisional; Region: PRK15049 1009846013940 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1009846013941 Aspartase; Region: Aspartase; cd01357 1009846013942 active sites [active] 1009846013943 tetramer interface [polypeptide binding]; other site 1009846013944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013945 transcriptional activator TtdR; Provisional; Region: PRK09801 1009846013946 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846013947 putative effector binding pocket; other site 1009846013948 dimerization interface [polypeptide binding]; other site 1009846013949 L-asparaginase II; Region: Asparaginase_II; pfam06089 1009846013950 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1009846013951 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846013952 N-terminal plug; other site 1009846013953 ligand-binding site [chemical binding]; other site 1009846013954 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1009846013955 Predicted membrane protein [Function unknown]; Region: COG3817 1009846013956 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1009846013957 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1009846013958 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1009846013959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846013960 active site 1009846013961 phosphorylation site [posttranslational modification] 1009846013962 intermolecular recognition site; other site 1009846013963 CheB methylesterase; Region: CheB_methylest; pfam01339 1009846013964 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846013965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846013966 active site 1009846013967 phosphorylation site [posttranslational modification] 1009846013968 intermolecular recognition site; other site 1009846013969 dimerization interface [polypeptide binding]; other site 1009846013970 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846013971 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846013972 metal binding site [ion binding]; metal-binding site 1009846013973 active site 1009846013974 I-site; other site 1009846013975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1009846013976 GAF domain; Region: GAF; pfam01590 1009846013977 PAS domain S-box; Region: sensory_box; TIGR00229 1009846013978 PAS domain; Region: PAS; smart00091 1009846013979 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846013980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846013981 metal binding site [ion binding]; metal-binding site 1009846013982 active site 1009846013983 I-site; other site 1009846013984 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846013985 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846013986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846013987 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1009846013988 putative effector binding pocket; other site 1009846013989 putative dimerization interface [polypeptide binding]; other site 1009846013990 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846013991 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1009846013992 catalytic triad [active] 1009846013993 dimer interface [polypeptide binding]; other site 1009846013994 conserved cis-peptide bond; other site 1009846013995 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1009846013996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1009846013997 active site 1009846013998 motif I; other site 1009846013999 motif II; other site 1009846014000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014003 dimerization interface [polypeptide binding]; other site 1009846014004 shikimate transporter; Provisional; Region: PRK09952 1009846014005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014006 putative substrate translocation pore; other site 1009846014007 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1009846014008 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1009846014009 tetrameric interface [polypeptide binding]; other site 1009846014010 NAD binding site [chemical binding]; other site 1009846014011 catalytic residues [active] 1009846014012 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846014013 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1009846014014 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1009846014015 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1009846014016 Na binding site [ion binding]; other site 1009846014017 putative substrate binding site [chemical binding]; other site 1009846014018 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1009846014019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014021 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 1009846014022 putative substrate binding pocket [chemical binding]; other site 1009846014023 putative dimerization interface [polypeptide binding]; other site 1009846014024 Predicted permeases [General function prediction only]; Region: COG0679 1009846014025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846014026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014027 putative substrate translocation pore; other site 1009846014028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014030 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846014031 dimerization interface [polypeptide binding]; other site 1009846014032 substrate binding pocket [chemical binding]; other site 1009846014033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1009846014034 substrate binding pocket [chemical binding]; other site 1009846014035 membrane-bound complex binding site; other site 1009846014036 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 1009846014037 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1009846014038 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1009846014039 Ligand binding site; other site 1009846014040 Putative Catalytic site; other site 1009846014041 DXD motif; other site 1009846014042 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1009846014043 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1009846014044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1009846014045 binding surface 1009846014046 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1009846014047 TPR motif; other site 1009846014048 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1009846014049 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846014050 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1009846014051 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1009846014052 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846014053 Type II/IV secretion system protein; Region: T2SE; pfam00437 1009846014054 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1009846014055 ATP binding site [chemical binding]; other site 1009846014056 Walker A motif; other site 1009846014057 hexamer interface [polypeptide binding]; other site 1009846014058 Walker B motif; other site 1009846014059 AAA domain; Region: AAA_31; pfam13614 1009846014060 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1009846014061 Type IV pili component [Cell motility and secretion]; Region: COG5461 1009846014062 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1009846014063 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1009846014064 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1009846014065 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1009846014066 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1009846014067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1009846014068 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009846014069 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846014070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014071 ABC-ATPase subunit interface; other site 1009846014072 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1009846014073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014074 dimer interface [polypeptide binding]; other site 1009846014075 conserved gate region; other site 1009846014076 putative PBP binding loops; other site 1009846014077 ABC-ATPase subunit interface; other site 1009846014078 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1009846014079 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1009846014080 Walker A/P-loop; other site 1009846014081 ATP binding site [chemical binding]; other site 1009846014082 Q-loop/lid; other site 1009846014083 ABC transporter signature motif; other site 1009846014084 Walker B; other site 1009846014085 D-loop; other site 1009846014086 H-loop/switch region; other site 1009846014087 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1009846014088 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1009846014089 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1009846014090 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1009846014091 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1009846014092 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1009846014093 peptide binding site [polypeptide binding]; other site 1009846014094 Domain of unknown function (DUF427); Region: DUF427; cl00998 1009846014095 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1009846014096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846014097 substrate binding pocket [chemical binding]; other site 1009846014098 membrane-bound complex binding site; other site 1009846014099 hinge residues; other site 1009846014100 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1009846014101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014103 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846014104 putative effector binding pocket; other site 1009846014105 dimerization interface [polypeptide binding]; other site 1009846014106 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1009846014107 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1009846014108 putative active site [active] 1009846014109 metal binding site [ion binding]; metal-binding site 1009846014110 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1009846014111 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1009846014112 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1009846014113 nudix motif; other site 1009846014114 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 1009846014115 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1009846014116 putative catalytic site [active] 1009846014117 putative metal binding site [ion binding]; other site 1009846014118 putative phosphate binding site [ion binding]; other site 1009846014119 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846014120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014121 DNA-binding site [nucleotide binding]; DNA binding site 1009846014122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846014123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846014124 homodimer interface [polypeptide binding]; other site 1009846014125 catalytic residue [active] 1009846014126 short chain dehydrogenase; Provisional; Region: PRK08339 1009846014127 classical (c) SDRs; Region: SDR_c; cd05233 1009846014128 NAD(P) binding site [chemical binding]; other site 1009846014129 active site 1009846014130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846014131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846014132 active site 1009846014133 catalytic tetrad [active] 1009846014134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014136 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1009846014137 substrate binding pocket [chemical binding]; other site 1009846014138 dimerization interface [polypeptide binding]; other site 1009846014139 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1009846014140 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1009846014141 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1009846014142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846014143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1009846014144 active site 1009846014145 metal binding site [ion binding]; metal-binding site 1009846014146 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1009846014147 active site 1009846014148 catalytic site [active] 1009846014149 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846014150 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846014151 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1009846014152 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1009846014153 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1009846014154 shikimate binding site; other site 1009846014155 NAD(P) binding site [chemical binding]; other site 1009846014156 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1009846014157 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1009846014158 trimer interface [polypeptide binding]; other site 1009846014159 active site 1009846014160 dimer interface [polypeptide binding]; other site 1009846014161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014162 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846014163 putative substrate translocation pore; other site 1009846014164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014165 putative substrate translocation pore; other site 1009846014166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846014167 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846014168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014169 DNA-binding site [nucleotide binding]; DNA binding site 1009846014170 FCD domain; Region: FCD; pfam07729 1009846014171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014172 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1009846014173 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1009846014174 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1009846014175 active site 1009846014176 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1009846014177 active site 1 [active] 1009846014178 dimer interface [polypeptide binding]; other site 1009846014179 hexamer interface [polypeptide binding]; other site 1009846014180 active site 2 [active] 1009846014181 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1009846014182 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1009846014183 EamA-like transporter family; Region: EamA; pfam00892 1009846014184 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846014185 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1009846014186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014188 dimerization interface [polypeptide binding]; other site 1009846014189 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1009846014190 Proline racemase; Region: Pro_racemase; pfam05544 1009846014191 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846014192 ornithine cyclodeaminase; Validated; Region: PRK06141 1009846014193 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846014194 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846014195 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1009846014196 putative active site [active] 1009846014197 putative substrate binding site [chemical binding]; other site 1009846014198 ATP binding site [chemical binding]; other site 1009846014199 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1009846014200 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1009846014201 TM-ABC transporter signature motif; other site 1009846014202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846014203 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1009846014204 TM-ABC transporter signature motif; other site 1009846014205 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1009846014206 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1009846014207 Walker A/P-loop; other site 1009846014208 ATP binding site [chemical binding]; other site 1009846014209 Q-loop/lid; other site 1009846014210 ABC transporter signature motif; other site 1009846014211 Walker B; other site 1009846014212 D-loop; other site 1009846014213 H-loop/switch region; other site 1009846014214 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1009846014215 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1009846014216 Walker A/P-loop; other site 1009846014217 ATP binding site [chemical binding]; other site 1009846014218 Q-loop/lid; other site 1009846014219 ABC transporter signature motif; other site 1009846014220 Walker B; other site 1009846014221 D-loop; other site 1009846014222 H-loop/switch region; other site 1009846014223 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1009846014224 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846014225 dimer interface [polypeptide binding]; other site 1009846014226 active site 1009846014227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846014228 NAD(P) binding site [chemical binding]; other site 1009846014229 active site 1009846014230 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1009846014231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846014232 DNA binding residues [nucleotide binding] 1009846014233 dimerization interface [polypeptide binding]; other site 1009846014234 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1009846014235 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1009846014236 putative ligand binding site [chemical binding]; other site 1009846014237 enoyl-CoA hydratase; Provisional; Region: PRK07658 1009846014238 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846014239 substrate binding site [chemical binding]; other site 1009846014240 oxyanion hole (OAH) forming residues; other site 1009846014241 trimer interface [polypeptide binding]; other site 1009846014242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1009846014243 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1009846014244 putative FMN binding site [chemical binding]; other site 1009846014245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846014246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846014247 Probable beta-xylosidase; Provisional; Region: PLN03080 1009846014248 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1009846014249 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1009846014250 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846014251 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1009846014252 enoyl-CoA hydratase; Provisional; Region: PRK06688 1009846014253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846014254 substrate binding site [chemical binding]; other site 1009846014255 oxyanion hole (OAH) forming residues; other site 1009846014256 trimer interface [polypeptide binding]; other site 1009846014257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1009846014258 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1009846014259 NAD binding site [chemical binding]; other site 1009846014260 homodimer interface [polypeptide binding]; other site 1009846014261 homotetramer interface [polypeptide binding]; other site 1009846014262 active site 1009846014263 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846014264 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846014265 trimer interface [polypeptide binding]; other site 1009846014266 eyelet of channel; other site 1009846014267 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1009846014268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846014269 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1009846014270 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1009846014271 acyl-activating enzyme (AAE) consensus motif; other site 1009846014272 putative AMP binding site [chemical binding]; other site 1009846014273 putative active site [active] 1009846014274 acyl-activating enzyme (AAE) consensus motif; other site 1009846014275 putative CoA binding site [chemical binding]; other site 1009846014276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014279 dimerization interface [polypeptide binding]; other site 1009846014280 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1009846014281 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1009846014282 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 1009846014283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014284 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846014285 putative substrate translocation pore; other site 1009846014286 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846014287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846014288 active site 1009846014289 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1009846014290 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846014291 NAD(P) binding site [chemical binding]; other site 1009846014292 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1009846014293 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846014294 FMN binding site [chemical binding]; other site 1009846014295 substrate binding site [chemical binding]; other site 1009846014296 putative catalytic residue [active] 1009846014297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846014298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846014299 active site 1009846014300 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1009846014301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846014302 substrate binding site [chemical binding]; other site 1009846014303 oxyanion hole (OAH) forming residues; other site 1009846014304 trimer interface [polypeptide binding]; other site 1009846014305 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1009846014306 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846014307 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1009846014308 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1009846014309 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1009846014310 homotrimer interaction site [polypeptide binding]; other site 1009846014311 putative active site [active] 1009846014312 FAD dependent oxidoreductase; Region: DAO; pfam01266 1009846014313 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846014314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014315 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1009846014316 putative substrate translocation pore; other site 1009846014317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1009846014318 pyrroline-5-carboxylate reductase; Region: PLN02688 1009846014319 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1009846014320 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846014321 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1009846014322 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1009846014323 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846014324 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846014325 HutD; Region: HutD; cl01532 1009846014326 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1009846014327 Ligand binding site [chemical binding]; other site 1009846014328 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1009846014329 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1009846014330 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1009846014331 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1009846014332 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1009846014333 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846014334 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846014335 trimer interface [polypeptide binding]; other site 1009846014336 eyelet of channel; other site 1009846014337 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1009846014338 Proline dehydrogenase; Region: Pro_dh; pfam01619 1009846014339 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846014340 NAD(P) binding site [chemical binding]; other site 1009846014341 catalytic residues [active] 1009846014342 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846014343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014344 dimer interface [polypeptide binding]; other site 1009846014345 conserved gate region; other site 1009846014346 putative PBP binding loops; other site 1009846014347 ABC-ATPase subunit interface; other site 1009846014348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014349 dimer interface [polypeptide binding]; other site 1009846014350 conserved gate region; other site 1009846014351 putative PBP binding loops; other site 1009846014352 ABC-ATPase subunit interface; other site 1009846014353 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846014354 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1009846014355 Walker A/P-loop; other site 1009846014356 ATP binding site [chemical binding]; other site 1009846014357 Q-loop/lid; other site 1009846014358 ABC transporter signature motif; other site 1009846014359 Walker B; other site 1009846014360 D-loop; other site 1009846014361 H-loop/switch region; other site 1009846014362 TOBE domain; Region: TOBE_2; pfam08402 1009846014363 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846014364 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1009846014365 NAD(P) binding site [chemical binding]; other site 1009846014366 catalytic residues [active] 1009846014367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846014368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846014369 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1009846014370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846014373 dimerization interface [polypeptide binding]; other site 1009846014374 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1009846014375 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1009846014376 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1009846014377 Proline racemase; Region: Pro_racemase; pfam05544 1009846014378 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1009846014379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846014380 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1009846014381 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1009846014382 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1009846014383 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846014384 NAD binding site [chemical binding]; other site 1009846014385 catalytic residues [active] 1009846014386 choline dehydrogenase; Validated; Region: PRK02106 1009846014387 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1009846014388 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846014389 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846014390 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 1009846014391 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1009846014392 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1009846014393 substrate binding pocket [chemical binding]; other site 1009846014394 active site 1009846014395 iron coordination sites [ion binding]; other site 1009846014396 enoyl-CoA hydratase; Provisional; Region: PRK08290 1009846014397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846014398 substrate binding site [chemical binding]; other site 1009846014399 oxyanion hole (OAH) forming residues; other site 1009846014400 trimer interface [polypeptide binding]; other site 1009846014401 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1009846014402 CoA binding domain; Region: CoA_binding_2; pfam13380 1009846014403 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1009846014404 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1009846014405 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1009846014406 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1009846014407 NADP binding site [chemical binding]; other site 1009846014408 dimer interface [polypeptide binding]; other site 1009846014409 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1009846014410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014412 dimerization interface [polypeptide binding]; other site 1009846014413 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1009846014414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846014415 NAD(P) binding site [chemical binding]; other site 1009846014416 active site 1009846014417 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846014418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014419 DNA-binding site [nucleotide binding]; DNA binding site 1009846014420 FCD domain; Region: FCD; pfam07729 1009846014421 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846014422 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1009846014423 Walker A/P-loop; other site 1009846014424 ATP binding site [chemical binding]; other site 1009846014425 Q-loop/lid; other site 1009846014426 ABC transporter signature motif; other site 1009846014427 Walker B; other site 1009846014428 D-loop; other site 1009846014429 H-loop/switch region; other site 1009846014430 TOBE domain; Region: TOBE_2; pfam08402 1009846014431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014432 dimer interface [polypeptide binding]; other site 1009846014433 conserved gate region; other site 1009846014434 putative PBP binding loops; other site 1009846014435 ABC-ATPase subunit interface; other site 1009846014436 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846014437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014438 dimer interface [polypeptide binding]; other site 1009846014439 conserved gate region; other site 1009846014440 putative PBP binding loops; other site 1009846014441 ABC-ATPase subunit interface; other site 1009846014442 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1009846014443 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846014444 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1009846014445 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846014446 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1009846014447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1009846014448 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1009846014449 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846014450 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1009846014451 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1009846014452 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846014453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846014454 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846014455 substrate binding pocket [chemical binding]; other site 1009846014456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846014457 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846014458 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1009846014459 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1009846014460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846014461 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846014462 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1009846014463 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1009846014464 Cupin domain; Region: Cupin_2; pfam07883 1009846014465 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846014466 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846014467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846014468 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1009846014469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014470 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846014471 putative substrate translocation pore; other site 1009846014472 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1009846014473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846014475 dimerization interface [polypeptide binding]; other site 1009846014476 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1009846014477 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1009846014478 putative NAD(P) binding site [chemical binding]; other site 1009846014479 putative substrate binding site [chemical binding]; other site 1009846014480 catalytic Zn binding site [ion binding]; other site 1009846014481 structural Zn binding site [ion binding]; other site 1009846014482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846014483 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1009846014484 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1009846014485 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1009846014486 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1009846014487 classical (c) SDRs; Region: SDR_c; cd05233 1009846014488 NAD(P) binding site [chemical binding]; other site 1009846014489 active site 1009846014490 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009846014491 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1009846014492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846014493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846014494 homodimer interface [polypeptide binding]; other site 1009846014495 catalytic residue [active] 1009846014496 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1009846014497 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846014498 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846014499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014500 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846014501 dimerization interface [polypeptide binding]; other site 1009846014502 substrate binding pocket [chemical binding]; other site 1009846014503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014505 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846014506 dimerization interface [polypeptide binding]; other site 1009846014507 substrate binding pocket [chemical binding]; other site 1009846014508 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846014509 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1009846014510 metal binding site [ion binding]; metal-binding site 1009846014511 putative dimer interface [polypeptide binding]; other site 1009846014512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014513 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846014514 putative substrate translocation pore; other site 1009846014515 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846014516 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1009846014517 Moco binding site; other site 1009846014518 metal coordination site [ion binding]; other site 1009846014519 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1009846014520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014521 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846014522 putative substrate translocation pore; other site 1009846014523 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009846014524 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1009846014525 active site pocket [active] 1009846014526 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1009846014527 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1009846014528 NAD binding site [chemical binding]; other site 1009846014529 ligand binding site [chemical binding]; other site 1009846014530 catalytic site [active] 1009846014531 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1009846014532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014533 DNA-binding site [nucleotide binding]; DNA binding site 1009846014534 FCD domain; Region: FCD; pfam07729 1009846014535 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1009846014536 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846014537 Walker A/P-loop; other site 1009846014538 ATP binding site [chemical binding]; other site 1009846014539 Q-loop/lid; other site 1009846014540 ABC transporter signature motif; other site 1009846014541 Walker B; other site 1009846014542 D-loop; other site 1009846014543 H-loop/switch region; other site 1009846014544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014545 dimer interface [polypeptide binding]; other site 1009846014546 conserved gate region; other site 1009846014547 putative PBP binding loops; other site 1009846014548 ABC-ATPase subunit interface; other site 1009846014549 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846014550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846014551 substrate binding pocket [chemical binding]; other site 1009846014552 membrane-bound complex binding site; other site 1009846014553 hinge residues; other site 1009846014554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846014555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846014556 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846014557 putative effector binding pocket; other site 1009846014558 dimerization interface [polypeptide binding]; other site 1009846014559 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1009846014560 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1009846014561 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1009846014562 G1 box; other site 1009846014563 putative GEF interaction site [polypeptide binding]; other site 1009846014564 GTP/Mg2+ binding site [chemical binding]; other site 1009846014565 Switch I region; other site 1009846014566 G2 box; other site 1009846014567 G3 box; other site 1009846014568 Switch II region; other site 1009846014569 G4 box; other site 1009846014570 G5 box; other site 1009846014571 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1009846014572 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1009846014573 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1009846014574 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1009846014575 selenocysteine synthase; Provisional; Region: PRK04311 1009846014576 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1009846014577 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1009846014578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846014579 catalytic residue [active] 1009846014580 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1009846014581 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1009846014582 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1009846014583 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1009846014584 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1009846014585 4Fe-4S binding domain; Region: Fer4; cl02805 1009846014586 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1009846014587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1009846014588 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1009846014589 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1009846014590 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1009846014591 molybdopterin cofactor binding site; other site 1009846014592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1009846014593 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1009846014594 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846014595 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846014596 trimer interface [polypeptide binding]; other site 1009846014597 eyelet of channel; other site 1009846014598 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1009846014599 dimer interface [polypeptide binding]; other site 1009846014600 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1009846014601 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009846014602 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1009846014603 active site 1009846014604 tetramer interface; other site 1009846014605 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1009846014606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846014607 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1009846014608 putative ADP-binding pocket [chemical binding]; other site 1009846014609 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1009846014610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846014611 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1009846014612 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1009846014613 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009846014614 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1009846014615 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1009846014616 NADP-binding site; other site 1009846014617 homotetramer interface [polypeptide binding]; other site 1009846014618 substrate binding site [chemical binding]; other site 1009846014619 homodimer interface [polypeptide binding]; other site 1009846014620 active site 1009846014621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846014622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846014623 NAD(P) binding site [chemical binding]; other site 1009846014624 active site 1009846014625 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1009846014626 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1009846014627 homodimer interface [polypeptide binding]; other site 1009846014628 substrate-cofactor binding pocket; other site 1009846014629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846014630 catalytic residue [active] 1009846014631 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1009846014632 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1009846014633 active site 1009846014634 tetramer interface [polypeptide binding]; other site 1009846014635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1009846014636 active site 1009846014637 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1009846014638 Colicin V production protein; Region: Colicin_V; pfam02674 1009846014639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1009846014640 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1009846014641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1009846014642 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1009846014643 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1009846014644 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1009846014645 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1009846014646 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1009846014647 substrate binding site [chemical binding]; other site 1009846014648 active site 1009846014649 catalytic residues [active] 1009846014650 heterodimer interface [polypeptide binding]; other site 1009846014651 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1009846014652 DNA methylase; Region: N6_N4_Mtase; pfam01555 1009846014653 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1009846014654 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1009846014655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846014656 catalytic residue [active] 1009846014657 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1009846014658 active site 1009846014659 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1009846014660 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1009846014661 dimerization interface 3.5A [polypeptide binding]; other site 1009846014662 active site 1009846014663 FimV N-terminal domain; Region: FimV_core; TIGR03505 1009846014664 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1009846014665 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1009846014666 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009846014667 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1009846014668 tartrate dehydrogenase; Region: TTC; TIGR02089 1009846014669 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1009846014670 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1009846014671 substrate binding site [chemical binding]; other site 1009846014672 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1009846014673 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1009846014674 substrate binding site [chemical binding]; other site 1009846014675 ligand binding site [chemical binding]; other site 1009846014676 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1009846014677 glutathione s-transferase; Provisional; Region: PTZ00057 1009846014678 GSH binding site (G-site) [chemical binding]; other site 1009846014679 C-terminal domain interface [polypeptide binding]; other site 1009846014680 dimer interface [polypeptide binding]; other site 1009846014681 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1009846014682 dimer interface [polypeptide binding]; other site 1009846014683 N-terminal domain interface [polypeptide binding]; other site 1009846014684 substrate binding pocket (H-site) [chemical binding]; other site 1009846014685 lysine transporter; Provisional; Region: PRK10836 1009846014686 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846014687 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846014688 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846014689 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1009846014690 Amidinotransferase; Region: Amidinotransf; cl12043 1009846014691 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1009846014692 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1009846014693 dimer interface [polypeptide binding]; other site 1009846014694 active site 1009846014695 citrylCoA binding site [chemical binding]; other site 1009846014696 NADH binding [chemical binding]; other site 1009846014697 cationic pore residues; other site 1009846014698 oxalacetate/citrate binding site [chemical binding]; other site 1009846014699 coenzyme A binding site [chemical binding]; other site 1009846014700 catalytic triad [active] 1009846014701 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1009846014702 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1009846014703 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1009846014704 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 1009846014705 L-aspartate oxidase; Provisional; Region: PRK06175 1009846014706 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1009846014707 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1009846014708 SdhC subunit interface [polypeptide binding]; other site 1009846014709 proximal heme binding site [chemical binding]; other site 1009846014710 cardiolipin binding site; other site 1009846014711 Iron-sulfur protein interface; other site 1009846014712 proximal quinone binding site [chemical binding]; other site 1009846014713 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1009846014714 Iron-sulfur protein interface; other site 1009846014715 proximal quinone binding site [chemical binding]; other site 1009846014716 SdhD (CybS) interface [polypeptide binding]; other site 1009846014717 proximal heme binding site [chemical binding]; other site 1009846014718 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1009846014719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014720 DNA-binding site [nucleotide binding]; DNA binding site 1009846014721 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1009846014722 malate dehydrogenase; Provisional; Region: PRK05442 1009846014723 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1009846014724 NAD(P) binding site [chemical binding]; other site 1009846014725 dimer interface [polypeptide binding]; other site 1009846014726 malate binding site [chemical binding]; other site 1009846014727 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1009846014728 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1009846014729 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1009846014730 aconitate hydratase; Provisional; Region: acnA; PRK12881 1009846014731 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1009846014732 substrate binding site [chemical binding]; other site 1009846014733 ligand binding site [chemical binding]; other site 1009846014734 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1009846014735 substrate binding site [chemical binding]; other site 1009846014736 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1009846014737 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1009846014738 putative hydrophobic ligand binding site [chemical binding]; other site 1009846014739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846014740 dimerization interface [polypeptide binding]; other site 1009846014741 putative DNA binding site [nucleotide binding]; other site 1009846014742 putative Zn2+ binding site [ion binding]; other site 1009846014743 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1009846014744 peptidase domain interface [polypeptide binding]; other site 1009846014745 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1009846014746 active site 1009846014747 catalytic triad [active] 1009846014748 calcium binding site [ion binding]; other site 1009846014749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846014751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014752 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846014753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014754 dimer interface [polypeptide binding]; other site 1009846014755 conserved gate region; other site 1009846014756 putative PBP binding loops; other site 1009846014757 ABC-ATPase subunit interface; other site 1009846014758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014759 dimer interface [polypeptide binding]; other site 1009846014760 conserved gate region; other site 1009846014761 putative PBP binding loops; other site 1009846014762 ABC-ATPase subunit interface; other site 1009846014763 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1009846014764 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846014765 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846014766 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1009846014767 Walker A/P-loop; other site 1009846014768 ATP binding site [chemical binding]; other site 1009846014769 Q-loop/lid; other site 1009846014770 ABC transporter signature motif; other site 1009846014771 Walker B; other site 1009846014772 D-loop; other site 1009846014773 H-loop/switch region; other site 1009846014774 TOBE domain; Region: TOBE_2; pfam08402 1009846014775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846014776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846014777 DNA-binding site [nucleotide binding]; DNA binding site 1009846014778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846014779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846014780 homodimer interface [polypeptide binding]; other site 1009846014781 catalytic residue [active] 1009846014782 lipase chaperone; Provisional; Region: PRK01294 1009846014783 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 1009846014784 Lipase (class 2); Region: Lipase_2; pfam01674 1009846014785 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1009846014786 PGAP1-like protein; Region: PGAP1; pfam07819 1009846014787 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1009846014788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846014789 N-terminal plug; other site 1009846014790 ligand-binding site [chemical binding]; other site 1009846014791 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1009846014792 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1009846014793 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1009846014794 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1009846014795 E3 interaction surface; other site 1009846014796 lipoyl attachment site [posttranslational modification]; other site 1009846014797 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846014798 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1009846014799 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1009846014800 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1009846014801 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1009846014802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846014803 S-adenosylmethionine binding site [chemical binding]; other site 1009846014804 NAD-dependent deacetylase; Provisional; Region: PRK05333 1009846014805 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1009846014806 NAD+ binding site [chemical binding]; other site 1009846014807 substrate binding site [chemical binding]; other site 1009846014808 Zn binding site [ion binding]; other site 1009846014809 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1009846014810 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1009846014811 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1009846014812 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846014813 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1009846014814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846014815 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1009846014816 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1009846014817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846014818 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846014819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846014820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014821 putative substrate translocation pore; other site 1009846014822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846014823 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1009846014824 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846014825 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846014826 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846014827 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1009846014828 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1009846014829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846014830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846014831 active site 1009846014832 phosphorylation site [posttranslational modification] 1009846014833 intermolecular recognition site; other site 1009846014834 dimerization interface [polypeptide binding]; other site 1009846014835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846014836 DNA binding site [nucleotide binding] 1009846014837 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1009846014838 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1009846014839 FtsX-like permease family; Region: FtsX; pfam02687 1009846014840 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1009846014841 peptidase domain interface [polypeptide binding]; other site 1009846014842 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1009846014843 active site 1009846014844 catalytic triad [active] 1009846014845 calcium binding site [ion binding]; other site 1009846014846 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1009846014847 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1009846014848 putative active site [active] 1009846014849 catalytic site [active] 1009846014850 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1009846014851 putative active site [active] 1009846014852 catalytic site [active] 1009846014853 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1009846014854 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1009846014855 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1009846014856 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1009846014857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846014858 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1009846014859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846014860 DNA binding residues [nucleotide binding] 1009846014861 DNA primase; Validated; Region: dnaG; PRK05667 1009846014862 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1009846014863 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1009846014864 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1009846014865 active site 1009846014866 metal binding site [ion binding]; metal-binding site 1009846014867 interdomain interaction site; other site 1009846014868 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1009846014869 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1009846014870 Yqey-like protein; Region: YqeY; pfam09424 1009846014871 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1009846014872 Predicted flavoproteins [General function prediction only]; Region: COG2081 1009846014873 UGMP family protein; Validated; Region: PRK09604 1009846014874 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1009846014875 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1009846014876 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1009846014877 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1009846014878 TPP-binding site; other site 1009846014879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1009846014880 PYR/PP interface [polypeptide binding]; other site 1009846014881 dimer interface [polypeptide binding]; other site 1009846014882 TPP binding site [chemical binding]; other site 1009846014883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1009846014884 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1009846014885 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1009846014886 substrate binding pocket [chemical binding]; other site 1009846014887 chain length determination region; other site 1009846014888 substrate-Mg2+ binding site; other site 1009846014889 catalytic residues [active] 1009846014890 aspartate-rich region 1; other site 1009846014891 active site lid residues [active] 1009846014892 aspartate-rich region 2; other site 1009846014893 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1009846014894 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846014895 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1009846014896 [2Fe-2S] cluster binding site [ion binding]; other site 1009846014897 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1009846014898 alpha subunit interface [polypeptide binding]; other site 1009846014899 active site 1009846014900 substrate binding site [chemical binding]; other site 1009846014901 Fe binding site [ion binding]; other site 1009846014902 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1009846014903 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1009846014904 active site residue [active] 1009846014905 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1009846014906 active site residue [active] 1009846014907 Dienelactone hydrolase family; Region: DLH; pfam01738 1009846014908 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1009846014909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846014910 DNA polymerase I; Provisional; Region: PRK05755 1009846014911 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1009846014912 active site 1009846014913 metal binding site 1 [ion binding]; metal-binding site 1009846014914 putative 5' ssDNA interaction site; other site 1009846014915 metal binding site 3; metal-binding site 1009846014916 metal binding site 2 [ion binding]; metal-binding site 1009846014917 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1009846014918 putative DNA binding site [nucleotide binding]; other site 1009846014919 putative metal binding site [ion binding]; other site 1009846014920 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1009846014921 active site 1009846014922 catalytic site [active] 1009846014923 substrate binding site [chemical binding]; other site 1009846014924 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1009846014925 active site 1009846014926 DNA binding site [nucleotide binding] 1009846014927 catalytic site [active] 1009846014928 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1009846014929 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1009846014930 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846014931 conserved cys residue [active] 1009846014932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846014933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846014934 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1009846014935 AMP nucleosidase; Provisional; Region: PRK08292 1009846014936 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1009846014937 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1009846014938 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1009846014939 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1009846014940 putative active site [active] 1009846014941 putative substrate binding site [chemical binding]; other site 1009846014942 ATP binding site [chemical binding]; other site 1009846014943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846014944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846014945 putative DNA binding site [nucleotide binding]; other site 1009846014946 putative Zn2+ binding site [ion binding]; other site 1009846014947 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1009846014948 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 1009846014949 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1009846014950 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1009846014951 active site 1009846014952 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1009846014953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846014954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846014955 dimer interface [polypeptide binding]; other site 1009846014956 conserved gate region; other site 1009846014957 putative PBP binding loops; other site 1009846014958 ABC-ATPase subunit interface; other site 1009846014959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846014960 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1009846014961 Walker A/P-loop; other site 1009846014962 ATP binding site [chemical binding]; other site 1009846014963 Q-loop/lid; other site 1009846014964 ABC transporter signature motif; other site 1009846014965 Walker B; other site 1009846014966 D-loop; other site 1009846014967 H-loop/switch region; other site 1009846014968 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1009846014969 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1009846014970 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1009846014971 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1009846014972 CHAD domain; Region: CHAD; pfam05235 1009846014973 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1009846014974 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1009846014975 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1009846014976 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1009846014977 core domain interface [polypeptide binding]; other site 1009846014978 delta subunit interface [polypeptide binding]; other site 1009846014979 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1009846014980 EamA-like transporter family; Region: EamA; pfam00892 1009846014981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846014982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846014983 dimer interface [polypeptide binding]; other site 1009846014984 phosphorylation site [posttranslational modification] 1009846014985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846014986 ATP binding site [chemical binding]; other site 1009846014987 Mg2+ binding site [ion binding]; other site 1009846014988 G-X-G motif; other site 1009846014989 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1009846014990 Domain of unknown function DUF21; Region: DUF21; pfam01595 1009846014991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1009846014992 Transporter associated domain; Region: CorC_HlyC; smart01091 1009846014993 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1009846014994 thiamine phosphate binding site [chemical binding]; other site 1009846014995 active site 1009846014996 pyrophosphate binding site [ion binding]; other site 1009846014997 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1009846014998 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1009846014999 active site 1009846015000 catalytic site [active] 1009846015001 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1009846015002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846015003 S-adenosylmethionine binding site [chemical binding]; other site 1009846015004 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846015005 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1009846015006 putative C-terminal domain interface [polypeptide binding]; other site 1009846015007 putative GSH binding site (G-site) [chemical binding]; other site 1009846015008 putative dimer interface [polypeptide binding]; other site 1009846015009 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1009846015010 putative N-terminal domain interface [polypeptide binding]; other site 1009846015011 putative dimer interface [polypeptide binding]; other site 1009846015012 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846015013 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1009846015014 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1009846015015 active site 1009846015016 metal binding site [ion binding]; metal-binding site 1009846015017 RES domain; Region: RES; smart00953 1009846015018 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1009846015019 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1009846015020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846015021 substrate binding pocket [chemical binding]; other site 1009846015022 membrane-bound complex binding site; other site 1009846015023 hinge residues; other site 1009846015024 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846015025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846015026 Walker A motif; other site 1009846015027 ATP binding site [chemical binding]; other site 1009846015028 Walker B motif; other site 1009846015029 arginine finger; other site 1009846015030 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846015031 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1009846015032 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1009846015033 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1009846015034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1009846015035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015036 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846015037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015039 putative substrate translocation pore; other site 1009846015040 Predicted transcriptional regulators [Transcription]; Region: COG1733 1009846015041 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1009846015042 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846015043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846015044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1009846015045 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1009846015046 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1009846015047 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1009846015048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1009846015049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1009846015050 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1009846015051 DXD motif; other site 1009846015052 tyrosine kinase; Provisional; Region: PRK11519 1009846015053 Chain length determinant protein; Region: Wzz; pfam02706 1009846015054 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1009846015055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846015056 P-loop; other site 1009846015057 Magnesium ion binding site [ion binding]; other site 1009846015058 polysaccharide export protein Wza; Provisional; Region: PRK15078 1009846015059 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1009846015060 SLBB domain; Region: SLBB; pfam10531 1009846015061 SLBB domain; Region: SLBB; pfam10531 1009846015062 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1009846015063 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1009846015064 active site 1009846015065 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1009846015066 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1009846015067 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1009846015068 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1009846015069 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1009846015070 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1009846015071 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1009846015072 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1009846015073 Substrate binding site; other site 1009846015074 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1009846015075 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1009846015076 Transcriptional activator HlyU; Region: HlyU; cl02273 1009846015077 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 1009846015078 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1009846015079 Cysteine-rich domain; Region: CCG; pfam02754 1009846015080 Rubrerythrin [Energy production and conversion]; Region: COG1592 1009846015081 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1009846015082 binuclear metal center [ion binding]; other site 1009846015083 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1009846015084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846015085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1009846015086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846015087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1009846015088 YCII-related domain; Region: YCII; cl00999 1009846015089 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1009846015090 generic binding surface I; other site 1009846015091 generic binding surface II; other site 1009846015092 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1009846015093 putative active site [active] 1009846015094 putative catalytic site [active] 1009846015095 putative Mg binding site IVb [ion binding]; other site 1009846015096 putative phosphate binding site [ion binding]; other site 1009846015097 putative DNA binding site [nucleotide binding]; other site 1009846015098 putative Mg binding site IVa [ion binding]; other site 1009846015099 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1009846015100 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1009846015101 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1009846015102 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1009846015103 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1009846015104 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1009846015105 NAD(P) binding site [chemical binding]; other site 1009846015106 substrate binding site [chemical binding]; other site 1009846015107 dimer interface [polypeptide binding]; other site 1009846015108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846015109 short chain dehydrogenase; Validated; Region: PRK07069 1009846015110 NAD(P) binding site [chemical binding]; other site 1009846015111 active site 1009846015112 manganese transport protein MntH; Reviewed; Region: PRK00701 1009846015113 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1009846015114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015115 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846015116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015118 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1009846015119 substrate binding pocket [chemical binding]; other site 1009846015120 dimerization interface [polypeptide binding]; other site 1009846015121 OsmC-like protein; Region: OsmC; pfam02566 1009846015122 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1009846015123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1009846015124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846015125 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1009846015126 Walker A/P-loop; other site 1009846015127 ATP binding site [chemical binding]; other site 1009846015128 Q-loop/lid; other site 1009846015129 ABC transporter signature motif; other site 1009846015130 Walker B; other site 1009846015131 D-loop; other site 1009846015132 H-loop/switch region; other site 1009846015133 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846015134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1009846015136 putative effector binding pocket; other site 1009846015137 putative dimerization interface [polypeptide binding]; other site 1009846015138 LysR family transcriptional regulator; Provisional; Region: PRK14997 1009846015139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015140 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1009846015141 putative effector binding pocket; other site 1009846015142 putative dimerization interface [polypeptide binding]; other site 1009846015143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015145 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846015146 putative effector binding pocket; other site 1009846015147 dimerization interface [polypeptide binding]; other site 1009846015148 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1009846015149 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1009846015150 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1009846015151 Isochorismatase family; Region: Isochorismatase; pfam00857 1009846015152 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1009846015153 catalytic triad [active] 1009846015154 dimer interface [polypeptide binding]; other site 1009846015155 conserved cis-peptide bond; other site 1009846015156 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846015157 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846015158 trimer interface [polypeptide binding]; other site 1009846015159 eyelet of channel; other site 1009846015160 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846015161 NIPSNAP; Region: NIPSNAP; pfam07978 1009846015162 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1009846015163 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1009846015164 active site 1009846015165 dimer interface [polypeptide binding]; other site 1009846015166 metal binding site [ion binding]; metal-binding site 1009846015167 Predicted esterase [General function prediction only]; Region: COG0400 1009846015168 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1009846015169 Zn binding site [ion binding]; other site 1009846015170 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1009846015171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846015172 Zn binding site [ion binding]; other site 1009846015173 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1009846015174 active site 1009846015175 oxalacetate binding site [chemical binding]; other site 1009846015176 citrylCoA binding site [chemical binding]; other site 1009846015177 coenzyme A binding site [chemical binding]; other site 1009846015178 catalytic triad [active] 1009846015179 acyl-CoA synthetase; Validated; Region: PRK06188 1009846015180 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1009846015181 putative active site [active] 1009846015182 putative CoA binding site [chemical binding]; other site 1009846015183 putative AMP binding site [chemical binding]; other site 1009846015184 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1009846015185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846015186 DNA-binding site [nucleotide binding]; DNA binding site 1009846015187 UTRA domain; Region: UTRA; pfam07702 1009846015188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1009846015189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846015190 NAD(P) binding site [chemical binding]; other site 1009846015191 active site 1009846015192 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1009846015193 Lumazine binding domain; Region: Lum_binding; pfam00677 1009846015194 Lumazine binding domain; Region: Lum_binding; pfam00677 1009846015195 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1009846015196 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1009846015197 putative Cl- selectivity filter; other site 1009846015198 putative pore gating glutamate residue; other site 1009846015199 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1009846015200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015201 active site 1009846015202 phosphorylation site [posttranslational modification] 1009846015203 intermolecular recognition site; other site 1009846015204 CheB methylesterase; Region: CheB_methylest; pfam01339 1009846015205 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1009846015206 putative binding surface; other site 1009846015207 active site 1009846015208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846015209 ATP binding site [chemical binding]; other site 1009846015210 Mg2+ binding site [ion binding]; other site 1009846015211 G-X-G motif; other site 1009846015212 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1009846015213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015214 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846015215 active site 1009846015216 phosphorylation site [posttranslational modification] 1009846015217 intermolecular recognition site; other site 1009846015218 dimerization interface [polypeptide binding]; other site 1009846015219 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1009846015220 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1009846015221 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1009846015222 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1009846015223 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1009846015224 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1009846015225 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1009846015226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846015227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846015228 dimer interface [polypeptide binding]; other site 1009846015229 putative CheW interface [polypeptide binding]; other site 1009846015230 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846015231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015232 active site 1009846015233 phosphorylation site [posttranslational modification] 1009846015234 intermolecular recognition site; other site 1009846015235 dimerization interface [polypeptide binding]; other site 1009846015236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846015237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1009846015238 dimer interface [polypeptide binding]; other site 1009846015239 phosphorylation site [posttranslational modification] 1009846015240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846015241 Mg2+ binding site [ion binding]; other site 1009846015242 G-X-G motif; other site 1009846015243 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1009846015244 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846015245 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 1009846015246 NAD(P) binding site [chemical binding]; other site 1009846015247 catalytic residues [active] 1009846015248 acetolactate synthase; Reviewed; Region: PRK08322 1009846015249 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1009846015250 PYR/PP interface [polypeptide binding]; other site 1009846015251 dimer interface [polypeptide binding]; other site 1009846015252 TPP binding site [chemical binding]; other site 1009846015253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846015254 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1009846015255 TPP-binding site [chemical binding]; other site 1009846015256 dimer interface [polypeptide binding]; other site 1009846015257 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1009846015258 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1009846015259 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1009846015260 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1009846015261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846015262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846015263 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1009846015264 [2Fe-2S] cluster binding site [ion binding]; other site 1009846015265 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1009846015266 inter-subunit interface; other site 1009846015267 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 1009846015268 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 1009846015269 putative alpha subunit interface [polypeptide binding]; other site 1009846015270 putative active site [active] 1009846015271 putative substrate binding site [chemical binding]; other site 1009846015272 Fe binding site [ion binding]; other site 1009846015273 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846015274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015275 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846015276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015277 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1009846015278 dimerizarion interface [polypeptide binding]; other site 1009846015279 CrgA pocket; other site 1009846015280 substrate binding pocket [chemical binding]; other site 1009846015281 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1009846015282 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1009846015283 octamer interface [polypeptide binding]; other site 1009846015284 active site 1009846015285 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1009846015286 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1009846015287 dimer interface [polypeptide binding]; other site 1009846015288 active site 1009846015289 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1009846015290 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1009846015291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846015292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015294 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1009846015295 putative substrate binding pocket [chemical binding]; other site 1009846015296 putative dimerization interface [polypeptide binding]; other site 1009846015297 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 1009846015298 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846015299 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1009846015300 active site 1009846015301 FMN binding site [chemical binding]; other site 1009846015302 2,4-decadienoyl-CoA binding site; other site 1009846015303 catalytic residue [active] 1009846015304 4Fe-4S cluster binding site [ion binding]; other site 1009846015305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846015306 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846015307 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846015308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015309 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1009846015310 substrate binding site [chemical binding]; other site 1009846015311 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1009846015312 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1009846015313 substrate binding site [chemical binding]; other site 1009846015314 ligand binding site [chemical binding]; other site 1009846015315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846015316 MarR family; Region: MarR_2; pfam12802 1009846015317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015319 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846015320 putative effector binding pocket; other site 1009846015321 dimerization interface [polypeptide binding]; other site 1009846015322 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846015323 MarR family; Region: MarR_2; pfam12802 1009846015324 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1009846015325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846015326 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846015327 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1009846015328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015329 putative substrate translocation pore; other site 1009846015330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015331 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846015332 glutathione S-transferase; Provisional; Region: PRK15113 1009846015333 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1009846015334 C-terminal domain interface [polypeptide binding]; other site 1009846015335 GSH binding site (G-site) [chemical binding]; other site 1009846015336 dimer interface [polypeptide binding]; other site 1009846015337 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1009846015338 putative dimer interface [polypeptide binding]; other site 1009846015339 N-terminal domain interface [polypeptide binding]; other site 1009846015340 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846015341 TIGR02594 family protein; Region: TIGR02594 1009846015342 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846015343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015344 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1009846015345 dimerization interface [polypeptide binding]; other site 1009846015346 substrate binding pocket [chemical binding]; other site 1009846015347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015348 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846015349 putative substrate translocation pore; other site 1009846015350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1009846015351 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1009846015352 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1009846015353 active site 1009846015354 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1009846015355 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1009846015356 glutaminase active site [active] 1009846015357 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009846015358 dimer interface [polypeptide binding]; other site 1009846015359 active site 1009846015360 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009846015361 dimer interface [polypeptide binding]; other site 1009846015362 active site 1009846015363 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1009846015364 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1009846015365 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1009846015366 active site 1009846015367 homodimer interface [polypeptide binding]; other site 1009846015368 Cache domain; Region: Cache_1; pfam02743 1009846015369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846015370 dimerization interface [polypeptide binding]; other site 1009846015371 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846015372 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846015373 dimer interface [polypeptide binding]; other site 1009846015374 putative CheW interface [polypeptide binding]; other site 1009846015375 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1009846015376 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1009846015377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846015378 ligand binding site [chemical binding]; other site 1009846015379 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1009846015380 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1009846015381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846015382 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1009846015383 ligand binding site [chemical binding]; other site 1009846015384 flexible hinge region; other site 1009846015385 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1009846015386 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1009846015387 active site 1009846015388 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1009846015389 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1009846015390 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1009846015391 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1009846015392 NodB motif; other site 1009846015393 putative active site [active] 1009846015394 putative catalytic site [active] 1009846015395 putative Zn binding site [ion binding]; other site 1009846015396 hypothetical protein; Provisional; Region: PRK09936 1009846015397 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1009846015398 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846015399 putative C-terminal domain interface [polypeptide binding]; other site 1009846015400 putative GSH binding site (G-site) [chemical binding]; other site 1009846015401 putative dimer interface [polypeptide binding]; other site 1009846015402 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1009846015403 putative N-terminal domain interface [polypeptide binding]; other site 1009846015404 putative dimer interface [polypeptide binding]; other site 1009846015405 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846015406 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 1009846015407 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1009846015408 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 1009846015409 Cupin domain; Region: Cupin_2; cl17218 1009846015410 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1009846015411 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1009846015412 Walker A/P-loop; other site 1009846015413 ATP binding site [chemical binding]; other site 1009846015414 Q-loop/lid; other site 1009846015415 ABC transporter signature motif; other site 1009846015416 Walker B; other site 1009846015417 D-loop; other site 1009846015418 H-loop/switch region; other site 1009846015419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846015420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846015421 dimer interface [polypeptide binding]; other site 1009846015422 conserved gate region; other site 1009846015423 putative PBP binding loops; other site 1009846015424 ABC-ATPase subunit interface; other site 1009846015425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1009846015426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846015427 dimer interface [polypeptide binding]; other site 1009846015428 conserved gate region; other site 1009846015429 putative PBP binding loops; other site 1009846015430 ABC-ATPase subunit interface; other site 1009846015431 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1009846015432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846015433 substrate binding pocket [chemical binding]; other site 1009846015434 membrane-bound complex binding site; other site 1009846015435 hinge residues; other site 1009846015436 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1009846015437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015438 active site 1009846015439 phosphorylation site [posttranslational modification] 1009846015440 intermolecular recognition site; other site 1009846015441 dimerization interface [polypeptide binding]; other site 1009846015442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846015443 DNA binding site [nucleotide binding] 1009846015444 GAF domain; Region: GAF_3; pfam13492 1009846015445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846015446 dimer interface [polypeptide binding]; other site 1009846015447 phosphorylation site [posttranslational modification] 1009846015448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846015449 ATP binding site [chemical binding]; other site 1009846015450 Mg2+ binding site [ion binding]; other site 1009846015451 G-X-G motif; other site 1009846015452 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1009846015453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009846015454 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1009846015455 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1009846015456 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846015457 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846015458 trimer interface [polypeptide binding]; other site 1009846015459 eyelet of channel; other site 1009846015460 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1009846015461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846015462 DNA-binding site [nucleotide binding]; DNA binding site 1009846015463 UTRA domain; Region: UTRA; pfam07702 1009846015464 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1009846015465 homodimer interface [polypeptide binding]; other site 1009846015466 active site 1009846015467 TDP-binding site; other site 1009846015468 acceptor substrate-binding pocket; other site 1009846015469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846015470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846015471 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1009846015472 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846015473 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1009846015474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015475 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1009846015476 dimerizarion interface [polypeptide binding]; other site 1009846015477 CrgA pocket; other site 1009846015478 substrate binding pocket [chemical binding]; other site 1009846015479 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 1009846015480 lysine transporter; Provisional; Region: PRK10836 1009846015481 Cache domain; Region: Cache_1; pfam02743 1009846015482 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846015483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846015484 metal binding site [ion binding]; metal-binding site 1009846015485 active site 1009846015486 I-site; other site 1009846015487 Predicted membrane protein [Function unknown]; Region: COG1289 1009846015488 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1009846015489 argininosuccinate synthase; Validated; Region: PRK05370 1009846015490 argininosuccinate synthase; Provisional; Region: PRK13820 1009846015491 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1009846015492 active site 1009846015493 AAA domain; Region: AAA_28; pfam13521 1009846015494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015495 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846015496 putative substrate translocation pore; other site 1009846015497 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1009846015498 tartrate dehydrogenase; Region: TTC; TIGR02089 1009846015499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1009846015501 putative effector binding pocket; other site 1009846015502 putative dimerization interface [polypeptide binding]; other site 1009846015503 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846015504 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1009846015505 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1009846015506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846015507 Walker A motif; other site 1009846015508 ATP binding site [chemical binding]; other site 1009846015509 Walker B motif; other site 1009846015510 arginine finger; other site 1009846015511 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1009846015512 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1009846015513 hypothetical protein; Reviewed; Region: PRK09588 1009846015514 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1009846015515 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1009846015516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846015517 S-adenosylmethionine binding site [chemical binding]; other site 1009846015518 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1009846015519 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1009846015520 homodimer interface [polypeptide binding]; other site 1009846015521 substrate-cofactor binding pocket; other site 1009846015522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846015523 catalytic residue [active] 1009846015524 Phosphotransferase enzyme family; Region: APH; pfam01636 1009846015525 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1009846015526 active site 1009846015527 ATP binding site [chemical binding]; other site 1009846015528 substrate binding site [chemical binding]; other site 1009846015529 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1009846015530 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1009846015531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1009846015532 N-terminal plug; other site 1009846015533 ligand-binding site [chemical binding]; other site 1009846015534 AMP-binding domain protein; Validated; Region: PRK08315 1009846015535 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846015536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846015537 AMP binding site [chemical binding]; other site 1009846015538 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1009846015539 acyl-activating enzyme (AAE) consensus motif; other site 1009846015540 putative AMP binding site [chemical binding]; other site 1009846015541 putative active site [active] 1009846015542 putative CoA binding site [chemical binding]; other site 1009846015543 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 1009846015544 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 1009846015545 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 1009846015546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846015547 FeS/SAM binding site; other site 1009846015548 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1009846015549 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 1009846015550 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 1009846015551 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 1009846015552 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 1009846015553 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846015554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846015555 NAD(P) binding site [chemical binding]; other site 1009846015556 catalytic residues [active] 1009846015557 High potential iron-sulfur protein; Region: HIPIP; pfam01355 1009846015558 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1009846015559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1009846015560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846015561 Walker A motif; other site 1009846015562 ATP binding site [chemical binding]; other site 1009846015563 Walker B motif; other site 1009846015564 arginine finger; other site 1009846015565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846015566 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1009846015567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1009846015568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846015569 Walker A/P-loop; other site 1009846015570 ATP binding site [chemical binding]; other site 1009846015571 Q-loop/lid; other site 1009846015572 ABC transporter signature motif; other site 1009846015573 Walker B; other site 1009846015574 D-loop; other site 1009846015575 H-loop/switch region; other site 1009846015576 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1009846015577 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1009846015578 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846015579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846015580 trimer interface [polypeptide binding]; other site 1009846015581 eyelet of channel; other site 1009846015582 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1009846015583 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1009846015584 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1009846015585 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1009846015586 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1009846015587 FAD binding pocket [chemical binding]; other site 1009846015588 FAD binding motif [chemical binding]; other site 1009846015589 phosphate binding motif [ion binding]; other site 1009846015590 beta-alpha-beta structure motif; other site 1009846015591 NAD binding pocket [chemical binding]; other site 1009846015592 Heme binding pocket [chemical binding]; other site 1009846015593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846015594 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1009846015595 catalytic loop [active] 1009846015596 iron binding site [ion binding]; other site 1009846015597 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1009846015598 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846015599 putative C-terminal domain interface [polypeptide binding]; other site 1009846015600 putative GSH binding site (G-site) [chemical binding]; other site 1009846015601 putative dimer interface [polypeptide binding]; other site 1009846015602 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1009846015603 putative N-terminal domain interface [polypeptide binding]; other site 1009846015604 putative dimer interface [polypeptide binding]; other site 1009846015605 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846015606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015608 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846015609 putative effector binding pocket; other site 1009846015610 dimerization interface [polypeptide binding]; other site 1009846015611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846015612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846015613 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1009846015614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846015615 NAD(P) binding site [chemical binding]; other site 1009846015616 active site 1009846015617 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1009846015618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1009846015619 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846015620 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846015621 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1009846015622 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1009846015623 Phospholipid methyltransferase; Region: PEMT; cl17370 1009846015624 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846015625 Predicted flavoprotein [General function prediction only]; Region: COG0431 1009846015626 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 1009846015627 hypothetical protein; Provisional; Region: PRK09040 1009846015628 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1009846015629 ligand binding site [chemical binding]; other site 1009846015630 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1009846015631 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1009846015632 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 1009846015633 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1009846015634 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846015635 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846015636 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1009846015637 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009846015638 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1009846015639 putative active site pocket [active] 1009846015640 metal binding site [ion binding]; metal-binding site 1009846015641 transcriptional activator TtdR; Provisional; Region: PRK09801 1009846015642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846015644 dimerization interface [polypeptide binding]; other site 1009846015645 mercuric reductase; Validated; Region: PRK06370 1009846015646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846015647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1009846015648 transcriptional regulator; Provisional; Region: PRK10632 1009846015649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015650 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846015651 putative effector binding pocket; other site 1009846015652 putative dimerization interface [polypeptide binding]; other site 1009846015653 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1009846015654 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1009846015655 putative NAD(P) binding site [chemical binding]; other site 1009846015656 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1009846015657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015658 putative substrate translocation pore; other site 1009846015659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846015660 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1009846015661 substrate binding pocket [chemical binding]; other site 1009846015662 membrane-bound complex binding site; other site 1009846015663 hinge residues; other site 1009846015664 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1009846015665 putative dimer interface [polypeptide binding]; other site 1009846015666 HAMP domain; Region: HAMP; pfam00672 1009846015667 dimerization interface [polypeptide binding]; other site 1009846015668 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846015669 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846015670 dimer interface [polypeptide binding]; other site 1009846015671 putative CheW interface [polypeptide binding]; other site 1009846015672 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1009846015673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846015674 Coenzyme A binding pocket [chemical binding]; other site 1009846015675 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1009846015676 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1009846015677 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1009846015678 active site 1009846015679 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1009846015680 Na binding site [ion binding]; other site 1009846015681 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1009846015682 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846015683 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846015684 trimer interface [polypeptide binding]; other site 1009846015685 eyelet of channel; other site 1009846015686 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846015687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846015688 dimerization interface [polypeptide binding]; other site 1009846015689 putative Zn2+ binding site [ion binding]; other site 1009846015690 putative DNA binding site [nucleotide binding]; other site 1009846015691 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846015692 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1009846015693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846015694 Walker A/P-loop; other site 1009846015695 ATP binding site [chemical binding]; other site 1009846015696 Q-loop/lid; other site 1009846015697 ABC transporter signature motif; other site 1009846015698 Walker B; other site 1009846015699 D-loop; other site 1009846015700 H-loop/switch region; other site 1009846015701 TOBE domain; Region: TOBE_2; pfam08402 1009846015702 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1009846015703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846015704 dimer interface [polypeptide binding]; other site 1009846015705 conserved gate region; other site 1009846015706 putative PBP binding loops; other site 1009846015707 ABC-ATPase subunit interface; other site 1009846015708 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1009846015709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846015710 dimer interface [polypeptide binding]; other site 1009846015711 conserved gate region; other site 1009846015712 putative PBP binding loops; other site 1009846015713 ABC-ATPase subunit interface; other site 1009846015714 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1009846015715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1009846015716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846015717 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1009846015718 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846015719 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846015720 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1009846015721 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1009846015722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846015723 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846015724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846015725 putative DNA binding site [nucleotide binding]; other site 1009846015726 putative Zn2+ binding site [ion binding]; other site 1009846015727 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846015728 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1009846015729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846015730 Coenzyme A binding pocket [chemical binding]; other site 1009846015731 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1009846015732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846015733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015734 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1009846015735 NAD(P) binding site [chemical binding]; other site 1009846015736 catalytic residues [active] 1009846015737 choline dehydrogenase; Validated; Region: PRK02106 1009846015738 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1009846015739 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1009846015740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1009846015741 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846015742 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1009846015743 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1009846015744 active site 1009846015745 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1009846015746 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1009846015747 active site 1009846015748 LssY C-terminus; Region: LssY_C; pfam14067 1009846015749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846015750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015751 active site 1009846015752 phosphorylation site [posttranslational modification] 1009846015753 intermolecular recognition site; other site 1009846015754 dimerization interface [polypeptide binding]; other site 1009846015755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846015756 DNA binding residues [nucleotide binding] 1009846015757 dimerization interface [polypeptide binding]; other site 1009846015758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1009846015759 Histidine kinase; Region: HisKA_3; pfam07730 1009846015760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015761 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846015762 putative substrate translocation pore; other site 1009846015763 NMT1-like family; Region: NMT1_2; pfam13379 1009846015764 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1009846015765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1009846015766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846015767 active site 1009846015768 phosphorylation site [posttranslational modification] 1009846015769 intermolecular recognition site; other site 1009846015770 dimerization interface [polypeptide binding]; other site 1009846015771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846015772 DNA binding site [nucleotide binding] 1009846015773 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1009846015774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846015775 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1009846015776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846015777 dimer interface [polypeptide binding]; other site 1009846015778 phosphorylation site [posttranslational modification] 1009846015779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846015780 ATP binding site [chemical binding]; other site 1009846015781 Mg2+ binding site [ion binding]; other site 1009846015782 G-X-G motif; other site 1009846015783 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846015784 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1009846015785 putative DNA binding site [nucleotide binding]; other site 1009846015786 putative Zn2+ binding site [ion binding]; other site 1009846015787 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846015788 ornithine cyclodeaminase; Validated; Region: PRK07589 1009846015789 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846015790 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1009846015791 Amidinotransferase; Region: Amidinotransf; pfam02274 1009846015792 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1009846015793 nucleotide binding site [chemical binding]; other site 1009846015794 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1009846015795 SBD interface [polypeptide binding]; other site 1009846015796 DNA-K related protein; Region: DUF3731; pfam12531 1009846015797 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1009846015798 nucleotide binding site [chemical binding]; other site 1009846015799 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1009846015800 SBD interface [polypeptide binding]; other site 1009846015801 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 1009846015802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1009846015803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846015806 dimerization interface [polypeptide binding]; other site 1009846015807 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1009846015808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1009846015809 dimer interface [polypeptide binding]; other site 1009846015810 active site 1009846015811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1009846015812 substrate binding site [chemical binding]; other site 1009846015813 catalytic residue [active] 1009846015814 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1009846015815 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1009846015816 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1009846015817 Acid Phosphatase; Region: Acid_PPase; cl17256 1009846015818 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1009846015819 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846015820 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1009846015821 putative C-terminal domain interface [polypeptide binding]; other site 1009846015822 putative GSH binding site (G-site) [chemical binding]; other site 1009846015823 putative dimer interface [polypeptide binding]; other site 1009846015824 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1009846015825 dimer interface [polypeptide binding]; other site 1009846015826 N-terminal domain interface [polypeptide binding]; other site 1009846015827 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846015828 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846015829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1009846015830 MarR family; Region: MarR; pfam01047 1009846015831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015832 putative substrate translocation pore; other site 1009846015833 Cupin; Region: Cupin_6; pfam12852 1009846015834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846015836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015837 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1009846015838 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1009846015839 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1009846015840 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1009846015841 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1009846015842 enoyl-CoA hydratase; Validated; Region: PRK08788 1009846015843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846015844 substrate binding site [chemical binding]; other site 1009846015845 oxyanion hole (OAH) forming residues; other site 1009846015846 trimer interface [polypeptide binding]; other site 1009846015847 RNase II stability modulator; Provisional; Region: PRK10060 1009846015848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1009846015849 putative active site [active] 1009846015850 heme pocket [chemical binding]; other site 1009846015851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846015852 metal binding site [ion binding]; metal-binding site 1009846015853 active site 1009846015854 I-site; other site 1009846015855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846015856 5-oxoprolinase; Region: PLN02666 1009846015857 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1009846015858 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1009846015859 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1009846015860 benzoate transport; Region: 2A0115; TIGR00895 1009846015861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015862 putative substrate translocation pore; other site 1009846015863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015864 hypothetical protein; Provisional; Region: PRK05463 1009846015865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846015866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846015868 dimerization interface [polypeptide binding]; other site 1009846015869 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1009846015870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015871 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846015872 putative substrate translocation pore; other site 1009846015873 EamA-like transporter family; Region: EamA; pfam00892 1009846015874 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1009846015875 EamA-like transporter family; Region: EamA; pfam00892 1009846015876 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1009846015877 oligomerisation interface [polypeptide binding]; other site 1009846015878 mobile loop; other site 1009846015879 roof hairpin; other site 1009846015880 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1009846015881 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1009846015882 ring oligomerisation interface [polypeptide binding]; other site 1009846015883 ATP/Mg binding site [chemical binding]; other site 1009846015884 stacking interactions; other site 1009846015885 hinge regions; other site 1009846015886 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846015887 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846015888 eyelet of channel; other site 1009846015889 trimer interface [polypeptide binding]; other site 1009846015890 LysE type translocator; Region: LysE; cl00565 1009846015891 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1009846015892 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1009846015893 active site 1009846015894 nucleophile elbow; other site 1009846015895 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1009846015896 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1009846015897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846015898 catalytic residue [active] 1009846015899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846015900 non-specific DNA binding site [nucleotide binding]; other site 1009846015901 salt bridge; other site 1009846015902 sequence-specific DNA binding site [nucleotide binding]; other site 1009846015903 serine O-acetyltransferase; Region: cysE; TIGR01172 1009846015904 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1009846015905 trimer interface [polypeptide binding]; other site 1009846015906 active site 1009846015907 substrate binding site [chemical binding]; other site 1009846015908 CoA binding site [chemical binding]; other site 1009846015909 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1009846015910 active site residue [active] 1009846015911 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1009846015912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1009846015913 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846015914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846015915 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1009846015916 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1009846015917 Uncharacterized conserved protein [Function unknown]; Region: COG5135 1009846015918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846015919 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1009846015920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846015921 homodimer interface [polypeptide binding]; other site 1009846015922 catalytic residue [active] 1009846015923 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1009846015924 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846015925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846015926 non-specific DNA binding site [nucleotide binding]; other site 1009846015927 salt bridge; other site 1009846015928 sequence-specific DNA binding site [nucleotide binding]; other site 1009846015929 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1009846015930 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1009846015931 ATP binding site [chemical binding]; other site 1009846015932 Mg++ binding site [ion binding]; other site 1009846015933 motif III; other site 1009846015934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846015935 nucleotide binding region [chemical binding]; other site 1009846015936 ATP-binding site [chemical binding]; other site 1009846015937 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1009846015938 Predicted transcriptional regulators [Transcription]; Region: COG1733 1009846015939 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1009846015940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015941 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846015942 putative substrate translocation pore; other site 1009846015943 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1009846015944 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1009846015945 active site 1009846015946 dimer interface [polypeptide binding]; other site 1009846015947 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1009846015948 PAS domain; Region: PAS_9; pfam13426 1009846015949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846015950 putative active site [active] 1009846015951 heme pocket [chemical binding]; other site 1009846015952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846015953 DNA binding residues [nucleotide binding] 1009846015954 dimerization interface [polypeptide binding]; other site 1009846015955 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846015956 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846015957 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846015958 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846015959 dimerization interface [polypeptide binding]; other site 1009846015960 ligand binding site [chemical binding]; other site 1009846015961 CsbD-like; Region: CsbD; cl17424 1009846015962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846015963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846015964 DNA binding residues [nucleotide binding] 1009846015965 dimerization interface [polypeptide binding]; other site 1009846015966 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1009846015967 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1009846015968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846015969 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1009846015970 dimerization interface [polypeptide binding]; other site 1009846015971 substrate binding pocket [chemical binding]; other site 1009846015972 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1009846015973 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846015974 tetrameric interface [polypeptide binding]; other site 1009846015975 activator binding site; other site 1009846015976 NADP binding site [chemical binding]; other site 1009846015977 substrate binding site [chemical binding]; other site 1009846015978 catalytic residues [active] 1009846015979 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846015980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1009846015981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846015982 NAD(P) binding site [chemical binding]; other site 1009846015983 active site 1009846015984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1009846015985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1009846015986 DNA binding site [nucleotide binding] 1009846015987 domain linker motif; other site 1009846015988 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1009846015989 dimerization interface [polypeptide binding]; other site 1009846015990 ligand binding site [chemical binding]; other site 1009846015991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846015992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846015993 putative substrate translocation pore; other site 1009846015994 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1009846015995 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1009846015996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846015998 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1009846015999 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1009846016000 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1009846016001 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1009846016002 DNA binding site [nucleotide binding] 1009846016003 active site 1009846016004 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1009846016005 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846016006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016007 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1009846016008 oligomerization interface [polypeptide binding]; other site 1009846016009 active site 1009846016010 metal binding site [ion binding]; metal-binding site 1009846016011 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846016012 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846016013 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846016014 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1009846016015 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1009846016016 glutaminase active site [active] 1009846016017 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1009846016018 dimer interface [polypeptide binding]; other site 1009846016019 active site 1009846016020 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1009846016021 dimer interface [polypeptide binding]; other site 1009846016022 active site 1009846016023 PAAR motif; Region: PAAR_motif; pfam05488 1009846016024 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1009846016025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016026 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846016027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016028 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846016029 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1009846016030 putative C-terminal domain interface [polypeptide binding]; other site 1009846016031 putative GSH binding site (G-site) [chemical binding]; other site 1009846016032 putative dimer interface [polypeptide binding]; other site 1009846016033 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1009846016034 dimer interface [polypeptide binding]; other site 1009846016035 N-terminal domain interface [polypeptide binding]; other site 1009846016036 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846016037 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846016038 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846016039 trimer interface [polypeptide binding]; other site 1009846016040 eyelet of channel; other site 1009846016041 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1009846016042 iron-sulfur cluster [ion binding]; other site 1009846016043 [2Fe-2S] cluster binding site [ion binding]; other site 1009846016044 YciI-like protein; Reviewed; Region: PRK12863 1009846016045 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1009846016046 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1009846016047 dimer interface [polypeptide binding]; other site 1009846016048 active site 1009846016049 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1009846016050 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1009846016051 active site 1009846016052 dimer interface [polypeptide binding]; other site 1009846016053 metal binding site [ion binding]; metal-binding site 1009846016054 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846016055 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 1009846016056 NAD(P) binding site [chemical binding]; other site 1009846016057 catalytic residues [active] 1009846016058 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 1009846016059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016061 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846016062 putative effector binding pocket; other site 1009846016063 dimerization interface [polypeptide binding]; other site 1009846016064 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846016065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016066 putative substrate translocation pore; other site 1009846016067 PAAR motif; Region: PAAR_motif; pfam05488 1009846016068 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846016069 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1009846016070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846016071 catalytic residue [active] 1009846016072 Putative phosphatase (DUF442); Region: DUF442; cl17385 1009846016073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016074 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846016075 dimerization interface [polypeptide binding]; other site 1009846016076 putative effector binding pocket; other site 1009846016077 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1009846016078 conserved cys residue [active] 1009846016079 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846016080 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846016081 conserved cys residue [active] 1009846016082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016084 Amino acid permease; Region: AA_permease_2; pfam13520 1009846016085 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1009846016086 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1009846016087 dimer interface [polypeptide binding]; other site 1009846016088 active site 1009846016089 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1009846016090 folate binding site [chemical binding]; other site 1009846016091 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1009846016092 classical (c) SDRs; Region: SDR_c; cd05233 1009846016093 NAD(P) binding site [chemical binding]; other site 1009846016094 active site 1009846016095 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1009846016096 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846016097 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1009846016098 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846016099 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1009846016100 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1009846016101 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1009846016102 generic binding surface I; other site 1009846016103 generic binding surface II; other site 1009846016104 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1009846016105 putative active site [active] 1009846016106 putative catalytic site [active] 1009846016107 putative Mg binding site IVb [ion binding]; other site 1009846016108 putative phosphate binding site [ion binding]; other site 1009846016109 putative DNA binding site [nucleotide binding]; other site 1009846016110 putative Mg binding site IVa [ion binding]; other site 1009846016111 CopC domain; Region: CopC; pfam04234 1009846016112 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1009846016113 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1009846016114 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1009846016115 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1009846016116 Outer membrane efflux protein; Region: OEP; pfam02321 1009846016117 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1009846016118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016119 active site 1009846016120 phosphorylation site [posttranslational modification] 1009846016121 intermolecular recognition site; other site 1009846016122 dimerization interface [polypeptide binding]; other site 1009846016123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846016124 DNA binding site [nucleotide binding] 1009846016125 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1009846016126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1009846016127 dimerization interface [polypeptide binding]; other site 1009846016128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016129 dimer interface [polypeptide binding]; other site 1009846016130 phosphorylation site [posttranslational modification] 1009846016131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016132 ATP binding site [chemical binding]; other site 1009846016133 Mg2+ binding site [ion binding]; other site 1009846016134 G-X-G motif; other site 1009846016135 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1009846016136 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1009846016137 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1009846016138 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1009846016139 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846016140 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846016141 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1009846016142 Outer membrane efflux protein; Region: OEP; pfam02321 1009846016143 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1009846016144 glutathionine S-transferase; Provisional; Region: PRK10542 1009846016145 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1009846016146 C-terminal domain interface [polypeptide binding]; other site 1009846016147 GSH binding site (G-site) [chemical binding]; other site 1009846016148 dimer interface [polypeptide binding]; other site 1009846016149 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1009846016150 dimer interface [polypeptide binding]; other site 1009846016151 N-terminal domain interface [polypeptide binding]; other site 1009846016152 substrate binding pocket (H-site) [chemical binding]; other site 1009846016153 Predicted transcriptional regulators [Transcription]; Region: COG1733 1009846016154 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1009846016155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016156 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846016157 putative substrate translocation pore; other site 1009846016158 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1009846016159 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1009846016160 active site 1009846016161 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 1009846016162 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1009846016163 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1009846016164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1009846016165 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1009846016166 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1009846016167 active site 1009846016168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846016169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846016170 DNA binding residues [nucleotide binding] 1009846016171 dimerization interface [polypeptide binding]; other site 1009846016172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846016175 dimerization interface [polypeptide binding]; other site 1009846016176 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846016177 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846016178 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1009846016179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846016180 DNA binding residues [nucleotide binding] 1009846016181 dimerization interface [polypeptide binding]; other site 1009846016182 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1009846016183 agmatinase; Region: agmatinase; TIGR01230 1009846016184 oligomer interface [polypeptide binding]; other site 1009846016185 putative active site [active] 1009846016186 Mn binding site [ion binding]; other site 1009846016187 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846016188 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1009846016189 NAD(P) binding site [chemical binding]; other site 1009846016190 catalytic residues [active] 1009846016191 catalytic residues [active] 1009846016192 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846016193 putative DnaG-like primase; Region: PHA02031 1009846016194 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1009846016195 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1009846016196 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1009846016197 metal coordination site [ion binding]; other site 1009846016198 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1009846016199 active site 1009846016200 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846016201 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846016202 trimer interface [polypeptide binding]; other site 1009846016203 eyelet of channel; other site 1009846016204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846016205 Coenzyme A binding pocket [chemical binding]; other site 1009846016206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846016207 dimer interface [polypeptide binding]; other site 1009846016208 conserved gate region; other site 1009846016209 putative PBP binding loops; other site 1009846016210 ABC-ATPase subunit interface; other site 1009846016211 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1009846016212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846016213 Walker A/P-loop; other site 1009846016214 ATP binding site [chemical binding]; other site 1009846016215 Q-loop/lid; other site 1009846016216 ABC transporter signature motif; other site 1009846016217 Walker B; other site 1009846016218 D-loop; other site 1009846016219 H-loop/switch region; other site 1009846016220 TOBE domain; Region: TOBE_2; pfam08402 1009846016221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1009846016222 nucleoside/Zn binding site; other site 1009846016223 dimer interface [polypeptide binding]; other site 1009846016224 catalytic motif [active] 1009846016225 cyanate hydratase; Validated; Region: PRK02866 1009846016226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1009846016227 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1009846016228 oligomer interface [polypeptide binding]; other site 1009846016229 active site 1009846016230 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1009846016231 active site clefts [active] 1009846016232 zinc binding site [ion binding]; other site 1009846016233 dimer interface [polypeptide binding]; other site 1009846016234 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1009846016235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016236 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1009846016237 dimerization interface [polypeptide binding]; other site 1009846016238 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1009846016239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846016242 dimerization interface [polypeptide binding]; other site 1009846016243 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1009846016244 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1009846016245 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1009846016246 dimer interface [polypeptide binding]; other site 1009846016247 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1009846016248 active site 1009846016249 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1009846016250 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1009846016251 dimer interface [polypeptide binding]; other site 1009846016252 active site 1009846016253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1009846016254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846016255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846016256 active site 1009846016257 catalytic tetrad [active] 1009846016258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016260 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1009846016261 putative effector binding pocket; other site 1009846016262 putative dimerization interface [polypeptide binding]; other site 1009846016263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846016264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846016265 pyruvate dehydrogenase; Provisional; Region: PRK09124 1009846016266 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1009846016267 PYR/PP interface [polypeptide binding]; other site 1009846016268 tetramer interface [polypeptide binding]; other site 1009846016269 dimer interface [polypeptide binding]; other site 1009846016270 TPP binding site [chemical binding]; other site 1009846016271 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1009846016272 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1009846016273 TPP-binding site [chemical binding]; other site 1009846016274 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846016275 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1009846016276 putative DNA binding site [nucleotide binding]; other site 1009846016277 putative Zn2+ binding site [ion binding]; other site 1009846016278 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846016279 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1009846016280 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1009846016281 dimer interface [polypeptide binding]; other site 1009846016282 TPP-binding site [chemical binding]; other site 1009846016283 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1009846016284 RES domain; Region: RES; pfam08808 1009846016285 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1009846016286 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1009846016287 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1009846016288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846016289 putative DNA binding site [nucleotide binding]; other site 1009846016290 putative Zn2+ binding site [ion binding]; other site 1009846016291 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846016292 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1009846016293 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1009846016294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846016295 catalytic residue [active] 1009846016296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016297 dimer interface [polypeptide binding]; other site 1009846016298 phosphorylation site [posttranslational modification] 1009846016299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016300 ATP binding site [chemical binding]; other site 1009846016301 Mg2+ binding site [ion binding]; other site 1009846016302 G-X-G motif; other site 1009846016303 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846016304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016305 active site 1009846016306 phosphorylation site [posttranslational modification] 1009846016307 intermolecular recognition site; other site 1009846016308 dimerization interface [polypeptide binding]; other site 1009846016309 transcriptional regulator RcsB; Provisional; Region: PRK10840 1009846016310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016311 active site 1009846016312 phosphorylation site [posttranslational modification] 1009846016313 intermolecular recognition site; other site 1009846016314 dimerization interface [polypeptide binding]; other site 1009846016315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846016316 DNA binding residues [nucleotide binding] 1009846016317 dimerization interface [polypeptide binding]; other site 1009846016318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846016319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016320 dimer interface [polypeptide binding]; other site 1009846016321 phosphorylation site [posttranslational modification] 1009846016322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016323 ATP binding site [chemical binding]; other site 1009846016324 Mg2+ binding site [ion binding]; other site 1009846016325 G-X-G motif; other site 1009846016326 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1009846016327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1009846016328 active site 1009846016329 phosphorylation site [posttranslational modification] 1009846016330 intermolecular recognition site; other site 1009846016331 dimerization interface [polypeptide binding]; other site 1009846016332 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1009846016333 Sel1-like repeats; Region: SEL1; smart00671 1009846016334 BetR domain; Region: BetR; pfam08667 1009846016335 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1009846016336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016337 active site 1009846016338 phosphorylation site [posttranslational modification] 1009846016339 intermolecular recognition site; other site 1009846016340 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1009846016341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846016342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016343 dimer interface [polypeptide binding]; other site 1009846016344 phosphorylation site [posttranslational modification] 1009846016345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016346 ATP binding site [chemical binding]; other site 1009846016347 Mg2+ binding site [ion binding]; other site 1009846016348 G-X-G motif; other site 1009846016349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016350 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846016351 active site 1009846016352 phosphorylation site [posttranslational modification] 1009846016353 intermolecular recognition site; other site 1009846016354 dimerization interface [polypeptide binding]; other site 1009846016355 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1009846016356 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1009846016357 catalytic residues [active] 1009846016358 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1009846016359 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846016360 acyl-activating enzyme (AAE) consensus motif; other site 1009846016361 AMP binding site [chemical binding]; other site 1009846016362 active site 1009846016363 CoA binding site [chemical binding]; other site 1009846016364 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 1009846016365 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1009846016366 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1009846016367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846016368 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1009846016369 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1009846016370 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1009846016371 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1009846016372 [2Fe-2S] cluster binding site [ion binding]; other site 1009846016373 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1009846016374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1009846016375 molybdopterin cofactor binding site; other site 1009846016376 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1009846016377 molybdopterin cofactor binding site; other site 1009846016378 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1009846016379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846016380 hypothetical protein; Provisional; Region: PRK11470 1009846016381 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846016382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846016383 putative DNA binding site [nucleotide binding]; other site 1009846016384 putative Zn2+ binding site [ion binding]; other site 1009846016385 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846016386 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1009846016387 Predicted membrane protein [Function unknown]; Region: COG4541 1009846016388 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1009846016389 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1009846016390 classical (c) SDRs; Region: SDR_c; cd05233 1009846016391 NAD(P) binding site [chemical binding]; other site 1009846016392 active site 1009846016393 Cupin domain; Region: Cupin_2; cl17218 1009846016394 allantoate amidohydrolase; Reviewed; Region: PRK12892 1009846016395 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1009846016396 active site 1009846016397 metal binding site [ion binding]; metal-binding site 1009846016398 dimer interface [polypeptide binding]; other site 1009846016399 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1009846016400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016401 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1009846016402 dimerization interface [polypeptide binding]; other site 1009846016403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846016404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846016405 catalytic residue [active] 1009846016406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846016407 dimerization interface [polypeptide binding]; other site 1009846016408 putative DNA binding site [nucleotide binding]; other site 1009846016409 putative Zn2+ binding site [ion binding]; other site 1009846016410 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846016411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846016412 DNA-binding site [nucleotide binding]; DNA binding site 1009846016413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846016414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846016415 homodimer interface [polypeptide binding]; other site 1009846016416 catalytic residue [active] 1009846016417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846016418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846016419 Coenzyme A binding pocket [chemical binding]; other site 1009846016420 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1009846016421 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846016422 catalytic residues [active] 1009846016423 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 1009846016424 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 1009846016425 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1009846016426 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1009846016427 Peptidase family M23; Region: Peptidase_M23; pfam01551 1009846016428 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1009846016429 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1009846016430 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846016431 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846016432 dimerization interface [polypeptide binding]; other site 1009846016433 ligand binding site [chemical binding]; other site 1009846016434 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1009846016435 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1009846016436 active site 1009846016437 Zn binding site [ion binding]; other site 1009846016438 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846016439 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1009846016440 putative DNA binding site [nucleotide binding]; other site 1009846016441 putative Zn2+ binding site [ion binding]; other site 1009846016442 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846016443 malate:quinone oxidoreductase; Validated; Region: PRK05257 1009846016444 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1009846016445 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1009846016446 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1009846016447 ATP binding site [chemical binding]; other site 1009846016448 Mg++ binding site [ion binding]; other site 1009846016449 motif III; other site 1009846016450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1009846016451 nucleotide binding region [chemical binding]; other site 1009846016452 ATP-binding site [chemical binding]; other site 1009846016453 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1009846016454 putative RNA binding site [nucleotide binding]; other site 1009846016455 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1009846016456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016457 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1009846016458 dimerization interface [polypeptide binding]; other site 1009846016459 substrate binding pocket [chemical binding]; other site 1009846016460 Amidohydrolase; Region: Amidohydro_2; pfam04909 1009846016461 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1009846016462 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1009846016463 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1009846016464 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1009846016465 active site 1 [active] 1009846016466 dimer interface [polypeptide binding]; other site 1009846016467 hexamer interface [polypeptide binding]; other site 1009846016468 active site 2 [active] 1009846016469 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 1009846016470 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1009846016471 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1009846016472 active site 1009846016473 catalytic residues [active] 1009846016474 metal binding site [ion binding]; metal-binding site 1009846016475 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1009846016476 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1009846016477 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009846016478 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1009846016479 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 1009846016480 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1009846016481 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1009846016482 NAD binding site [chemical binding]; other site 1009846016483 catalytic residues [active] 1009846016484 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1009846016485 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1009846016486 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1009846016487 tetramer interface [polypeptide binding]; other site 1009846016488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846016489 active site 1009846016490 metal binding site [ion binding]; metal-binding site 1009846016491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846016492 catalytic loop [active] 1009846016493 iron binding site [ion binding]; other site 1009846016494 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1009846016495 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846016496 catalytic loop [active] 1009846016497 iron binding site [ion binding]; other site 1009846016498 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1009846016499 FAD binding pocket [chemical binding]; other site 1009846016500 FAD binding motif [chemical binding]; other site 1009846016501 phosphate binding motif [ion binding]; other site 1009846016502 beta-alpha-beta structure motif; other site 1009846016503 NAD binding pocket [chemical binding]; other site 1009846016504 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1009846016505 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1009846016506 dimerization interface [polypeptide binding]; other site 1009846016507 putative path to active site cavity [active] 1009846016508 diiron center [ion binding]; other site 1009846016509 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1009846016510 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1009846016511 dinuclear metal binding motif [ion binding]; other site 1009846016512 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1009846016513 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1009846016514 V4R domain; Region: V4R; pfam02830 1009846016515 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1009846016516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846016517 Walker A motif; other site 1009846016518 ATP binding site [chemical binding]; other site 1009846016519 Walker B motif; other site 1009846016520 arginine finger; other site 1009846016521 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846016522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846016523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846016524 DNA-binding site [nucleotide binding]; DNA binding site 1009846016525 FCD domain; Region: FCD; pfam07729 1009846016526 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1009846016527 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1009846016528 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1009846016529 putative di-iron ligands [ion binding]; other site 1009846016530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016532 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846016533 putative effector binding pocket; other site 1009846016534 putative dimerization interface [polypeptide binding]; other site 1009846016535 benzoate transporter; Region: benE; TIGR00843 1009846016536 Benzoate membrane transport protein; Region: BenE; pfam03594 1009846016537 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1009846016538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846016539 NAD(P) binding site [chemical binding]; other site 1009846016540 active site 1009846016541 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846016542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016546 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1009846016547 putative dimerization interface [polypeptide binding]; other site 1009846016548 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1009846016549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1009846016550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1009846016551 pyrophosphatase PpaX; Provisional; Region: PRK13288 1009846016552 phage resistance protein; Provisional; Region: PRK10551 1009846016553 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1009846016554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1009846016555 DNA polymerase II; Reviewed; Region: PRK05762 1009846016556 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1009846016557 active site 1009846016558 catalytic site [active] 1009846016559 substrate binding site [chemical binding]; other site 1009846016560 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1009846016561 active site 1009846016562 metal-binding site 1009846016563 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1009846016564 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1009846016565 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846016566 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846016567 Outer membrane efflux protein; Region: OEP; pfam02321 1009846016568 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1009846016569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016570 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1009846016571 dimerization interface [polypeptide binding]; other site 1009846016572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016574 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846016575 putative effector binding pocket; other site 1009846016576 dimerization interface [polypeptide binding]; other site 1009846016577 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846016578 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846016579 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846016580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846016581 DNA-binding site [nucleotide binding]; DNA binding site 1009846016582 FCD domain; Region: FCD; pfam07729 1009846016583 DnaJ domain; Region: DnaJ; pfam00226 1009846016584 HSP70 interaction site [polypeptide binding]; other site 1009846016585 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1009846016586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016587 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1009846016588 substrate binding pocket [chemical binding]; other site 1009846016589 dimerization interface [polypeptide binding]; other site 1009846016590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846016591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846016592 active site 1009846016593 short chain dehydrogenase; Provisional; Region: PRK06172 1009846016594 classical (c) SDRs; Region: SDR_c; cd05233 1009846016595 NAD(P) binding site [chemical binding]; other site 1009846016596 active site 1009846016597 short chain dehydrogenase; Provisional; Region: PRK07035 1009846016598 classical (c) SDRs; Region: SDR_c; cd05233 1009846016599 NAD(P) binding site [chemical binding]; other site 1009846016600 active site 1009846016601 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1009846016602 Phosphotransferase enzyme family; Region: APH; pfam01636 1009846016603 putative active site [active] 1009846016604 putative substrate binding site [chemical binding]; other site 1009846016605 ATP binding site [chemical binding]; other site 1009846016606 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1009846016607 catalytic core [active] 1009846016608 transcriptional regulator; Provisional; Region: PRK10632 1009846016609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016610 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1009846016611 putative effector binding pocket; other site 1009846016612 dimerization interface [polypeptide binding]; other site 1009846016613 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1009846016614 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1009846016615 NAD(P) binding site [chemical binding]; other site 1009846016616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846016619 dimerization interface [polypeptide binding]; other site 1009846016620 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1009846016621 Protein of unknown function (DUF570); Region: DUF570; pfam04489 1009846016622 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846016623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846016624 DNA binding residues [nucleotide binding] 1009846016625 dimerization interface [polypeptide binding]; other site 1009846016626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1009846016627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846016628 acyl-activating enzyme (AAE) consensus motif; other site 1009846016629 AMP binding site [chemical binding]; other site 1009846016630 active site 1009846016631 CoA binding site [chemical binding]; other site 1009846016632 chaperone protein HchA; Provisional; Region: PRK04155 1009846016633 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1009846016634 conserved cys residue [active] 1009846016635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1009846016636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1009846016637 active site 1009846016638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846016639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846016640 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1009846016641 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1009846016642 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846016643 lipid-transfer protein; Provisional; Region: PRK08256 1009846016644 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1009846016645 active site 1009846016646 acyl-CoA synthetase; Validated; Region: PRK06188 1009846016647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1009846016648 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1009846016649 putative active site [active] 1009846016650 putative CoA binding site [chemical binding]; other site 1009846016651 putative AMP binding site [chemical binding]; other site 1009846016652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846016653 NAD(P) binding site [chemical binding]; other site 1009846016654 Cytochrome c; Region: Cytochrom_C; cl11414 1009846016655 Cytochrome c; Region: Cytochrom_C; cl11414 1009846016656 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1009846016657 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1009846016658 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1009846016659 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1009846016660 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1009846016661 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1009846016662 homotrimer interaction site [polypeptide binding]; other site 1009846016663 putative active site [active] 1009846016664 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1009846016665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846016666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846016667 Cytochrome c; Region: Cytochrom_C; cl11414 1009846016668 Cytochrome c; Region: Cytochrom_C; pfam00034 1009846016669 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1009846016670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846016671 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1009846016672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016673 active site 1009846016674 phosphorylation site [posttranslational modification] 1009846016675 intermolecular recognition site; other site 1009846016676 dimerization interface [polypeptide binding]; other site 1009846016677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1009846016678 DNA binding site [nucleotide binding] 1009846016679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846016680 HAMP domain; Region: HAMP; pfam00672 1009846016681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016682 dimer interface [polypeptide binding]; other site 1009846016683 phosphorylation site [posttranslational modification] 1009846016684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016685 ATP binding site [chemical binding]; other site 1009846016686 Mg2+ binding site [ion binding]; other site 1009846016687 G-X-G motif; other site 1009846016688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016689 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846016690 putative substrate translocation pore; other site 1009846016691 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1009846016692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846016694 dimerization interface [polypeptide binding]; other site 1009846016695 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1009846016696 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1009846016697 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1009846016698 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1009846016699 putative active site pocket [active] 1009846016700 putative metal binding site [ion binding]; other site 1009846016701 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846016702 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009846016703 inhibitor site; inhibition site 1009846016704 active site 1009846016705 dimer interface [polypeptide binding]; other site 1009846016706 catalytic residue [active] 1009846016707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016708 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846016709 putative substrate translocation pore; other site 1009846016710 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1009846016711 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1009846016712 Amidohydrolase; Region: Amidohydro_2; pfam04909 1009846016713 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846016714 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1009846016715 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1009846016716 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1009846016717 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1009846016718 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1009846016719 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1009846016720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846016722 putative substrate translocation pore; other site 1009846016723 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 1009846016724 RNA polymerase sigma factor; Provisional; Region: PRK12512 1009846016725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846016726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846016727 DNA binding residues [nucleotide binding] 1009846016728 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1009846016729 hypothetical protein; Provisional; Region: PRK05409 1009846016730 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1009846016731 Predicted membrane protein [Function unknown]; Region: COG2259 1009846016732 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1009846016733 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1009846016734 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1009846016735 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1009846016736 putative metal binding site [ion binding]; other site 1009846016737 putative homodimer interface [polypeptide binding]; other site 1009846016738 putative homotetramer interface [polypeptide binding]; other site 1009846016739 putative homodimer-homodimer interface [polypeptide binding]; other site 1009846016740 putative allosteric switch controlling residues; other site 1009846016741 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1009846016742 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 1009846016743 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1009846016744 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1009846016745 Chromate transporter; Region: Chromate_transp; pfam02417 1009846016746 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1009846016747 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1009846016748 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846016749 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846016750 FMN binding site [chemical binding]; other site 1009846016751 active site 1009846016752 substrate binding site [chemical binding]; other site 1009846016753 catalytic residue [active] 1009846016754 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846016755 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1009846016756 Helix-turn-helix domain; Region: HTH_31; pfam13560 1009846016757 sequence-specific DNA binding site [nucleotide binding]; other site 1009846016758 salt bridge; other site 1009846016759 RNA polymerase sigma factor; Provisional; Region: PRK11922 1009846016760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1009846016761 DNA binding residues [nucleotide binding] 1009846016762 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1009846016763 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1009846016764 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1009846016765 dimerization interface [polypeptide binding]; other site 1009846016766 DNA binding residues [nucleotide binding] 1009846016767 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1009846016768 DNA-binding site [nucleotide binding]; DNA binding site 1009846016769 RNA-binding motif; other site 1009846016770 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846016771 benzoate transport; Region: 2A0115; TIGR00895 1009846016772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846016773 putative substrate translocation pore; other site 1009846016774 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1009846016775 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1009846016776 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1009846016777 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1009846016778 tetramer interface [polypeptide binding]; other site 1009846016779 active site 1009846016780 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1009846016781 Coenzyme A transferase; Region: CoA_trans; cl17247 1009846016782 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1009846016783 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1009846016784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016786 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1009846016787 substrate binding pocket [chemical binding]; other site 1009846016788 dimerization interface [polypeptide binding]; other site 1009846016789 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1009846016790 GTP cyclohydrolase I; Provisional; Region: PLN03044 1009846016791 active site 1009846016792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846016793 short chain dehydrogenase; Provisional; Region: PRK09134 1009846016794 NAD(P) binding site [chemical binding]; other site 1009846016795 active site 1009846016796 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 1009846016797 serine O-acetyltransferase; Region: cysE; TIGR01172 1009846016798 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1009846016799 trimer interface [polypeptide binding]; other site 1009846016800 active site 1009846016801 substrate binding site [chemical binding]; other site 1009846016802 CoA binding site [chemical binding]; other site 1009846016803 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 1009846016804 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1009846016805 Ligand Binding Site [chemical binding]; other site 1009846016806 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1009846016807 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1009846016808 ligand binding site [chemical binding]; other site 1009846016809 flexible hinge region; other site 1009846016810 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1009846016811 putative switch regulator; other site 1009846016812 non-specific DNA interactions [nucleotide binding]; other site 1009846016813 DNA binding site [nucleotide binding] 1009846016814 sequence specific DNA binding site [nucleotide binding]; other site 1009846016815 putative cAMP binding site [chemical binding]; other site 1009846016816 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1009846016817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846016819 dimerization interface [polypeptide binding]; other site 1009846016820 Lysine efflux permease [General function prediction only]; Region: COG1279 1009846016821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846016822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846016823 active site 1009846016824 catalytic tetrad [active] 1009846016825 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1009846016826 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846016827 NAD(P) binding site [chemical binding]; other site 1009846016828 catalytic residues [active] 1009846016829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1009846016830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846016831 Predicted transcriptional regulators [Transcription]; Region: COG1695 1009846016832 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1009846016833 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1009846016834 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1009846016835 FAD binding pocket [chemical binding]; other site 1009846016836 FAD binding motif [chemical binding]; other site 1009846016837 phosphate binding motif [ion binding]; other site 1009846016838 NAD binding pocket [chemical binding]; other site 1009846016839 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1009846016840 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1009846016841 active site 1009846016842 acetoacetate decarboxylase; Provisional; Region: PRK02265 1009846016843 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 1009846016844 classical (c) SDRs; Region: SDR_c; cd05233 1009846016845 NAD(P) binding site [chemical binding]; other site 1009846016846 active site 1009846016847 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1009846016848 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1009846016849 nucleophile elbow; other site 1009846016850 Patatin phospholipase; Region: DUF3734; pfam12536 1009846016851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846016852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846016854 dimerization interface [polypeptide binding]; other site 1009846016855 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1009846016856 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1009846016857 transcriptional activator TtdR; Provisional; Region: PRK09801 1009846016858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846016859 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1009846016860 putative effector binding pocket; other site 1009846016861 putative dimerization interface [polypeptide binding]; other site 1009846016862 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1009846016863 tartrate dehydrogenase; Region: TTC; TIGR02089 1009846016864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1009846016865 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846016866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846016867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846016868 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846016869 Coenzyme A binding pocket [chemical binding]; other site 1009846016870 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1009846016871 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1009846016872 NAD(P) binding site [chemical binding]; other site 1009846016873 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1009846016874 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1009846016875 substrate-cofactor binding pocket; other site 1009846016876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846016877 catalytic residue [active] 1009846016878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846016879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846016880 non-specific DNA binding site [nucleotide binding]; other site 1009846016881 salt bridge; other site 1009846016882 sequence-specific DNA binding site [nucleotide binding]; other site 1009846016883 Cupin domain; Region: Cupin_2; pfam07883 1009846016884 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 1009846016885 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1009846016886 active site 1009846016887 catalytic residues [active] 1009846016888 Int/Topo IB signature motif; other site 1009846016889 DNA binding site [nucleotide binding] 1009846016890 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1009846016891 Initiator Replication protein; Region: Rep_3; pfam01051 1009846016892 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1009846016893 ParB-like nuclease domain; Region: ParB; smart00470 1009846016894 ParA-like protein; Provisional; Region: PHA02518 1009846016895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1009846016896 P-loop; other site 1009846016897 Magnesium ion binding site [ion binding]; other site 1009846016898 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1009846016899 ArsC family; Region: ArsC; pfam03960 1009846016900 catalytic residues [active] 1009846016901 Putative zinc-finger; Region: zf-HC2; pfam13490 1009846016902 RNA polymerase sigma factor; Provisional; Region: PRK12545 1009846016903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1009846016904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1009846016905 Predicted flavoprotein [General function prediction only]; Region: COG0431 1009846016906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1009846016907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1009846016908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846016909 dimer interface [polypeptide binding]; other site 1009846016910 phosphorylation site [posttranslational modification] 1009846016911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016912 ATP binding site [chemical binding]; other site 1009846016913 Mg2+ binding site [ion binding]; other site 1009846016914 G-X-G motif; other site 1009846016915 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846016916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016917 active site 1009846016918 phosphorylation site [posttranslational modification] 1009846016919 intermolecular recognition site; other site 1009846016920 dimerization interface [polypeptide binding]; other site 1009846016921 Response regulator receiver domain; Region: Response_reg; pfam00072 1009846016922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016923 active site 1009846016924 phosphorylation site [posttranslational modification] 1009846016925 intermolecular recognition site; other site 1009846016926 dimerization interface [polypeptide binding]; other site 1009846016927 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1009846016928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846016929 PAS domain; Region: PAS_9; pfam13426 1009846016930 putative active site [active] 1009846016931 heme pocket [chemical binding]; other site 1009846016932 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1009846016933 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846016934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846016935 metal binding site [ion binding]; metal-binding site 1009846016936 active site 1009846016937 I-site; other site 1009846016938 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1009846016939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846016940 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1009846016941 active site lid residues [active] 1009846016942 substrate binding pocket [chemical binding]; other site 1009846016943 catalytic residues [active] 1009846016944 substrate-Mg2+ binding site; other site 1009846016945 aspartate-rich region 1; other site 1009846016946 aspartate-rich region 2; other site 1009846016947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1009846016948 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1009846016949 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1009846016950 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1009846016951 Active site cavity [active] 1009846016952 catalytic acid [active] 1009846016953 hypothetical protein; Provisional; Region: PRK07077 1009846016954 VacJ like lipoprotein; Region: VacJ; cl01073 1009846016955 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1009846016956 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1009846016957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1009846016958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846016959 active site 1009846016960 phosphorylation site [posttranslational modification] 1009846016961 intermolecular recognition site; other site 1009846016962 dimerization interface [polypeptide binding]; other site 1009846016963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1009846016964 DNA binding residues [nucleotide binding] 1009846016965 dimerization interface [polypeptide binding]; other site 1009846016966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1009846016967 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1009846016968 Histidine kinase; Region: HisKA_3; pfam07730 1009846016969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846016970 ATP binding site [chemical binding]; other site 1009846016971 Mg2+ binding site [ion binding]; other site 1009846016972 G-X-G motif; other site 1009846016973 Cache domain; Region: Cache_1; pfam02743 1009846016974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846016975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846016976 metal binding site [ion binding]; metal-binding site 1009846016977 active site 1009846016978 I-site; other site 1009846016979 malate synthase G; Provisional; Region: PRK02999 1009846016980 active site 1009846016981 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1009846016982 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1009846016983 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1009846016984 Cysteine-rich domain; Region: CCG; pfam02754 1009846016985 Cysteine-rich domain; Region: CCG; pfam02754 1009846016986 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846016987 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1009846016988 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1009846016989 FAD binding domain; Region: FAD_binding_4; pfam01565 1009846016990 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1009846016991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846016992 DNA-binding site [nucleotide binding]; DNA binding site 1009846016993 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1009846016994 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1009846016995 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1009846016996 FMN binding site [chemical binding]; other site 1009846016997 substrate binding site [chemical binding]; other site 1009846016998 putative catalytic residue [active] 1009846016999 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1009846017000 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1009846017001 conserved cys residue [active] 1009846017002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017003 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1009846017004 SnoaL-like domain; Region: SnoaL_3; pfam13474 1009846017005 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1009846017006 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1009846017007 conserved cys residue [active] 1009846017008 short chain dehydrogenase; Provisional; Region: PRK06500 1009846017009 classical (c) SDRs; Region: SDR_c; cd05233 1009846017010 NAD(P) binding site [chemical binding]; other site 1009846017011 active site 1009846017012 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1009846017013 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846017014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846017015 DNA-binding site [nucleotide binding]; DNA binding site 1009846017016 FCD domain; Region: FCD; pfam07729 1009846017017 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 1009846017018 glutathionine S-transferase; Provisional; Region: PRK10542 1009846017019 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1009846017020 C-terminal domain interface [polypeptide binding]; other site 1009846017021 GSH binding site (G-site) [chemical binding]; other site 1009846017022 dimer interface [polypeptide binding]; other site 1009846017023 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1009846017024 dimer interface [polypeptide binding]; other site 1009846017025 N-terminal domain interface [polypeptide binding]; other site 1009846017026 substrate binding pocket (H-site) [chemical binding]; other site 1009846017027 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1009846017028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017029 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1009846017030 putative dimerization interface [polypeptide binding]; other site 1009846017031 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1009846017032 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846017033 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1009846017034 inhibitor site; inhibition site 1009846017035 active site 1009846017036 dimer interface [polypeptide binding]; other site 1009846017037 catalytic residue [active] 1009846017038 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1009846017039 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1009846017040 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1009846017041 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1009846017042 ligand binding site [chemical binding]; other site 1009846017043 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1009846017044 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1009846017045 Walker A/P-loop; other site 1009846017046 ATP binding site [chemical binding]; other site 1009846017047 Q-loop/lid; other site 1009846017048 ABC transporter signature motif; other site 1009846017049 Walker B; other site 1009846017050 D-loop; other site 1009846017051 H-loop/switch region; other site 1009846017052 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1009846017053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1009846017054 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1009846017055 TM-ABC transporter signature motif; other site 1009846017056 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1009846017057 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1009846017058 MarR family; Region: MarR_2; pfam12802 1009846017059 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1009846017060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1009846017061 substrate binding site [chemical binding]; other site 1009846017062 oxyanion hole (OAH) forming residues; other site 1009846017063 trimer interface [polypeptide binding]; other site 1009846017064 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846017065 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1009846017066 NAD(P) binding site [chemical binding]; other site 1009846017067 catalytic residues [active] 1009846017068 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1009846017069 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1009846017070 acyl-activating enzyme (AAE) consensus motif; other site 1009846017071 putative AMP binding site [chemical binding]; other site 1009846017072 putative active site [active] 1009846017073 putative CoA binding site [chemical binding]; other site 1009846017074 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1009846017075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017076 putative substrate translocation pore; other site 1009846017077 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846017078 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846017079 trimer interface [polypeptide binding]; other site 1009846017080 eyelet of channel; other site 1009846017081 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1009846017082 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1009846017083 active site 1009846017084 catalytic site [active] 1009846017085 substrate binding site [chemical binding]; other site 1009846017086 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846017087 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1009846017088 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 1009846017089 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1009846017090 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846017091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846017092 putative DNA binding site [nucleotide binding]; other site 1009846017093 putative Zn2+ binding site [ion binding]; other site 1009846017094 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846017095 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 1009846017096 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1009846017097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846017098 catalytic residue [active] 1009846017099 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846017100 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1009846017101 metal binding site [ion binding]; metal-binding site 1009846017102 putative dimer interface [polypeptide binding]; other site 1009846017103 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1009846017104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846017105 DNA-binding site [nucleotide binding]; DNA binding site 1009846017106 FCD domain; Region: FCD; pfam07729 1009846017107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017108 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846017109 putative substrate translocation pore; other site 1009846017110 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1009846017111 dihydropyrimidinase; Provisional; Region: PRK13404 1009846017112 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1009846017113 tetramer interface [polypeptide binding]; other site 1009846017114 active site 1009846017115 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1009846017116 Beta-lactamase; Region: Beta-lactamase; pfam00144 1009846017117 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1009846017118 Beta-lactamase; Region: Beta-lactamase; pfam00144 1009846017119 aminotransferase; Validated; Region: PRK07046 1009846017120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1009846017121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846017122 catalytic residue [active] 1009846017123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1009846017124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846017125 Coenzyme A binding pocket [chemical binding]; other site 1009846017126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846017127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846017128 non-specific DNA binding site [nucleotide binding]; other site 1009846017129 salt bridge; other site 1009846017130 sequence-specific DNA binding site [nucleotide binding]; other site 1009846017131 Cupin domain; Region: Cupin_2; pfam07883 1009846017132 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1009846017133 homotrimer interaction site [polypeptide binding]; other site 1009846017134 putative active site [active] 1009846017135 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1009846017136 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1009846017137 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1009846017138 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1009846017139 Spore germination protein; Region: Spore_permease; cl17796 1009846017140 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1009846017141 cytosine deaminase; Provisional; Region: PRK05985 1009846017142 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1009846017143 active site 1009846017144 cytosine deaminase; Provisional; Region: PRK05985 1009846017145 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1009846017146 active site 1009846017147 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1009846017148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846017149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846017151 dimerization interface [polypeptide binding]; other site 1009846017152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846017153 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1009846017154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1009846017155 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1009846017156 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1009846017157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846017158 non-specific DNA binding site [nucleotide binding]; other site 1009846017159 salt bridge; other site 1009846017160 sequence-specific DNA binding site [nucleotide binding]; other site 1009846017161 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1009846017162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846017163 substrate binding pocket [chemical binding]; other site 1009846017164 membrane-bound complex binding site; other site 1009846017165 hinge residues; other site 1009846017166 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1009846017167 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1009846017168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846017169 DNA-binding site [nucleotide binding]; DNA binding site 1009846017170 UTRA domain; Region: UTRA; pfam07702 1009846017171 short chain dehydrogenase; Provisional; Region: PRK07023 1009846017172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846017173 NAD(P) binding site [chemical binding]; other site 1009846017174 active site 1009846017175 hypothetical protein; Provisional; Region: PRK11239 1009846017176 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1009846017177 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1009846017178 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1009846017179 PRC-barrel domain; Region: PRC; pfam05239 1009846017180 carbon starvation protein A; Provisional; Region: PRK15015 1009846017181 Carbon starvation protein CstA; Region: CstA; pfam02554 1009846017182 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1009846017183 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1009846017184 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1009846017185 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1009846017186 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846017187 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1009846017188 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1009846017189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1009846017190 FeS/SAM binding site; other site 1009846017191 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1009846017192 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1009846017193 LytB protein; Region: LYTB; pfam02401 1009846017194 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1009846017195 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1009846017196 active site 1009846017197 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1009846017198 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1009846017199 putative NADP binding site [chemical binding]; other site 1009846017200 putative substrate binding site [chemical binding]; other site 1009846017201 active site 1009846017202 acylphosphatase; Provisional; Region: PRK14424 1009846017203 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1009846017204 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1009846017205 OpgC protein; Region: OpgC_C; pfam10129 1009846017206 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1009846017207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017208 putative substrate translocation pore; other site 1009846017209 POT family; Region: PTR2; cl17359 1009846017210 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1009846017211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846017212 non-specific DNA binding site [nucleotide binding]; other site 1009846017213 salt bridge; other site 1009846017214 sequence-specific DNA binding site [nucleotide binding]; other site 1009846017215 Cupin domain; Region: Cupin_2; pfam07883 1009846017216 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1009846017217 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1009846017218 peptide binding site [polypeptide binding]; other site 1009846017219 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1009846017220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1009846017221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846017222 dimer interface [polypeptide binding]; other site 1009846017223 conserved gate region; other site 1009846017224 putative PBP binding loops; other site 1009846017225 ABC-ATPase subunit interface; other site 1009846017226 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1009846017227 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1009846017228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846017229 dimer interface [polypeptide binding]; other site 1009846017230 conserved gate region; other site 1009846017231 putative PBP binding loops; other site 1009846017232 ABC-ATPase subunit interface; other site 1009846017233 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1009846017234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846017235 Walker A/P-loop; other site 1009846017236 ATP binding site [chemical binding]; other site 1009846017237 Q-loop/lid; other site 1009846017238 ABC transporter signature motif; other site 1009846017239 Walker B; other site 1009846017240 D-loop; other site 1009846017241 H-loop/switch region; other site 1009846017242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846017243 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1009846017244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1009846017245 Walker A/P-loop; other site 1009846017246 ATP binding site [chemical binding]; other site 1009846017247 Q-loop/lid; other site 1009846017248 ABC transporter signature motif; other site 1009846017249 Walker B; other site 1009846017250 D-loop; other site 1009846017251 H-loop/switch region; other site 1009846017252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1009846017253 outer membrane porin, OprD family; Region: OprD; pfam03573 1009846017254 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1009846017255 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1009846017256 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1009846017257 active site residue [active] 1009846017258 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1009846017259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846017260 Coenzyme A binding pocket [chemical binding]; other site 1009846017261 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1009846017262 trimer interface [polypeptide binding]; other site 1009846017263 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1009846017264 YadA-like C-terminal region; Region: YadA; pfam03895 1009846017265 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1009846017266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017267 Helix-turn-helix domain; Region: HTH_18; pfam12833 1009846017268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017269 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1009846017270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1009846017271 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846017272 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1009846017273 PAS fold; Region: PAS_4; pfam08448 1009846017274 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1009846017275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846017276 Walker B motif; other site 1009846017277 arginine finger; other site 1009846017278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846017279 H-NS histone family; Region: Histone_HNS; pfam00816 1009846017280 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1009846017281 CoA binding domain; Region: CoA_binding_2; pfam13380 1009846017282 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1009846017283 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1009846017284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1009846017285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1009846017286 Coenzyme A binding pocket [chemical binding]; other site 1009846017287 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1009846017288 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1009846017289 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846017290 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1009846017291 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1009846017292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1009846017293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1009846017294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1009846017295 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1009846017296 CGNR zinc finger; Region: zf-CGNR; pfam11706 1009846017297 Propionate catabolism activator; Region: PrpR_N; pfam06506 1009846017298 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1009846017299 PAS domain; Region: PAS; smart00091 1009846017300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846017301 Walker A motif; other site 1009846017302 ATP binding site [chemical binding]; other site 1009846017303 Walker B motif; other site 1009846017304 arginine finger; other site 1009846017305 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1009846017306 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1009846017307 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1009846017308 tetramer interface [polypeptide binding]; other site 1009846017309 active site 1009846017310 Mg2+/Mn2+ binding site [ion binding]; other site 1009846017311 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1009846017312 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1009846017313 dimer interface [polypeptide binding]; other site 1009846017314 active site 1009846017315 citrylCoA binding site [chemical binding]; other site 1009846017316 oxalacetate/citrate binding site [chemical binding]; other site 1009846017317 coenzyme A binding site [chemical binding]; other site 1009846017318 catalytic triad [active] 1009846017319 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1009846017320 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1009846017321 substrate binding site [chemical binding]; other site 1009846017322 ligand binding site [chemical binding]; other site 1009846017323 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1009846017324 substrate binding site [chemical binding]; other site 1009846017325 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1009846017326 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1009846017327 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1009846017328 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1009846017329 CoenzymeA binding site [chemical binding]; other site 1009846017330 subunit interaction site [polypeptide binding]; other site 1009846017331 PHB binding site; other site 1009846017332 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1009846017333 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1009846017334 dimer interface [polypeptide binding]; other site 1009846017335 ligand binding site [chemical binding]; other site 1009846017336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846017337 dimer interface [polypeptide binding]; other site 1009846017338 putative CheW interface [polypeptide binding]; other site 1009846017339 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1009846017340 putative active cleft [active] 1009846017341 MgtC family; Region: MgtC; pfam02308 1009846017342 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1009846017343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1009846017344 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1009846017345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1009846017346 metal-binding site [ion binding] 1009846017347 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1009846017348 metal-binding site [ion binding] 1009846017349 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1009846017350 metal-binding site [ion binding] 1009846017351 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1009846017352 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1009846017353 metal-binding site [ion binding] 1009846017354 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1009846017355 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1009846017356 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1009846017357 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1009846017358 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1009846017359 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1009846017360 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1009846017361 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1009846017362 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1009846017363 Sulfatase; Region: Sulfatase; cl17466 1009846017364 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1009846017365 Sulfatase; Region: Sulfatase; cl17466 1009846017366 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1009846017367 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1009846017368 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1009846017369 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1009846017370 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1009846017371 tetramer interface [polypeptide binding]; other site 1009846017372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846017373 catalytic residue [active] 1009846017374 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 1009846017375 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 1009846017376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017377 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1009846017378 putative dimerization interface [polypeptide binding]; other site 1009846017379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1009846017380 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1009846017381 active site residue [active] 1009846017382 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846017383 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1009846017384 C-terminal domain interface [polypeptide binding]; other site 1009846017385 GSH binding site (G-site) [chemical binding]; other site 1009846017386 dimer interface [polypeptide binding]; other site 1009846017387 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1009846017388 N-terminal domain interface [polypeptide binding]; other site 1009846017389 dimer interface [polypeptide binding]; other site 1009846017390 substrate binding pocket (H-site) [chemical binding]; other site 1009846017391 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1009846017392 active site 1009846017393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1009846017394 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1009846017395 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1009846017396 putative catalytic residue [active] 1009846017397 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1009846017398 putative hydrophobic ligand binding site [chemical binding]; other site 1009846017399 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1009846017400 putative hydrophobic ligand binding site [chemical binding]; other site 1009846017401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846017402 dimerization interface [polypeptide binding]; other site 1009846017403 putative DNA binding site [nucleotide binding]; other site 1009846017404 putative Zn2+ binding site [ion binding]; other site 1009846017405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1009846017406 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1009846017407 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1009846017408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846017409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846017410 short chain dehydrogenase; Validated; Region: PRK08264 1009846017411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846017412 NAD(P) binding site [chemical binding]; other site 1009846017413 active site 1009846017414 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1009846017415 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1009846017416 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1009846017417 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1009846017418 Predicted transcriptional regulators [Transcription]; Region: COG1510 1009846017419 MarR family; Region: MarR_2; pfam12802 1009846017420 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1009846017421 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1009846017422 putative NAD(P) binding site [chemical binding]; other site 1009846017423 active site 1009846017424 DoxX-like family; Region: DoxX_3; pfam13781 1009846017425 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1009846017426 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1009846017427 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1009846017428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846017429 NAD(P) binding site [chemical binding]; other site 1009846017430 active site 1009846017431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1009846017432 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1009846017433 putative C-terminal domain interface [polypeptide binding]; other site 1009846017434 putative GSH binding site (G-site) [chemical binding]; other site 1009846017435 putative dimer interface [polypeptide binding]; other site 1009846017436 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1009846017437 putative N-terminal domain interface [polypeptide binding]; other site 1009846017438 putative dimer interface [polypeptide binding]; other site 1009846017439 putative substrate binding pocket (H-site) [chemical binding]; other site 1009846017440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1009846017441 Beta-lactamase; Region: Beta-lactamase; pfam00144 1009846017442 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1009846017443 HIT family signature motif; other site 1009846017444 catalytic residue [active] 1009846017445 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1009846017446 hypothetical protein; Provisional; Region: PRK11171 1009846017447 Cupin domain; Region: Cupin_2; pfam07883 1009846017448 Cupin domain; Region: Cupin_2; pfam07883 1009846017449 Transglycosylase; Region: Transgly; pfam00912 1009846017450 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1009846017451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1009846017452 Predicted membrane protein [Function unknown]; Region: COG2860 1009846017453 UPF0126 domain; Region: UPF0126; pfam03458 1009846017454 UPF0126 domain; Region: UPF0126; pfam03458 1009846017455 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 1009846017456 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1009846017457 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1009846017458 trimer interface [polypeptide binding]; other site 1009846017459 eyelet of channel; other site 1009846017460 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1009846017461 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1009846017462 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1009846017463 Predicted deacylase [General function prediction only]; Region: COG3608 1009846017464 active site 1009846017465 Zn binding site [ion binding]; other site 1009846017466 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1009846017467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1009846017468 substrate binding pocket [chemical binding]; other site 1009846017469 membrane-bound complex binding site; other site 1009846017470 hinge residues; other site 1009846017471 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1009846017472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1009846017474 dimerization interface [polypeptide binding]; other site 1009846017475 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1009846017476 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1009846017477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1009846017478 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1009846017479 NAD(P) binding site [chemical binding]; other site 1009846017480 active site 1009846017481 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1009846017482 catalytic tetrad [active] 1009846017483 Putative cyclase; Region: Cyclase; pfam04199 1009846017484 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846017485 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846017486 FMN binding site [chemical binding]; other site 1009846017487 active site 1009846017488 substrate binding site [chemical binding]; other site 1009846017489 catalytic residue [active] 1009846017490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1009846017491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1009846017492 active site 1009846017493 catalytic tetrad [active] 1009846017494 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1009846017495 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1009846017496 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1009846017497 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1009846017498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017499 putative substrate translocation pore; other site 1009846017500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846017501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017502 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1009846017503 putative effector binding pocket; other site 1009846017504 dimerization interface [polypeptide binding]; other site 1009846017505 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1009846017506 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1009846017507 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1009846017508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846017509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846017510 short chain dehydrogenase; Provisional; Region: PRK08263 1009846017511 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1009846017512 NADP binding site [chemical binding]; other site 1009846017513 active site 1009846017514 steroid binding site; other site 1009846017515 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1009846017516 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1009846017517 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1009846017518 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1009846017519 NADP binding site [chemical binding]; other site 1009846017520 dimer interface [polypeptide binding]; other site 1009846017521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846017522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846017523 H-NS histone family; Region: Histone_HNS; pfam00816 1009846017524 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1009846017525 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1009846017526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1009846017527 classical (c) SDRs; Region: SDR_c; cd05233 1009846017528 NAD(P) binding site [chemical binding]; other site 1009846017529 active site 1009846017530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1009846017531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1009846017532 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1009846017533 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1009846017534 catalytic residues [active] 1009846017535 OsmC-like protein; Region: OsmC; pfam02566 1009846017536 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1009846017537 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1009846017538 FMN binding site [chemical binding]; other site 1009846017539 active site 1009846017540 substrate binding site [chemical binding]; other site 1009846017541 catalytic residue [active] 1009846017542 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1009846017543 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1009846017544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846017545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846017546 homodimer interface [polypeptide binding]; other site 1009846017547 catalytic residue [active] 1009846017548 L-asparagine permease; Provisional; Region: PRK15049 1009846017549 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1009846017550 active site 1 [active] 1009846017551 dimer interface [polypeptide binding]; other site 1009846017552 hexamer interface [polypeptide binding]; other site 1009846017553 active site 2 [active] 1009846017554 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1009846017555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846017556 Walker A motif; other site 1009846017557 ATP binding site [chemical binding]; other site 1009846017558 Walker B motif; other site 1009846017559 arginine finger; other site 1009846017560 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1009846017561 DNA-binding interface [nucleotide binding]; DNA binding site 1009846017562 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1009846017563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1009846017564 phosphate binding site [ion binding]; other site 1009846017565 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846017566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017567 putative substrate translocation pore; other site 1009846017568 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1009846017569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1009846017570 catalytic loop [active] 1009846017571 iron binding site [ion binding]; other site 1009846017572 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1009846017573 FAD binding pocket [chemical binding]; other site 1009846017574 conserved FAD binding motif [chemical binding]; other site 1009846017575 phosphate binding motif [ion binding]; other site 1009846017576 beta-alpha-beta structure motif; other site 1009846017577 NAD binding pocket [chemical binding]; other site 1009846017578 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1009846017579 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1009846017580 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1009846017581 [2Fe-2S] cluster binding site [ion binding]; other site 1009846017582 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1009846017583 alpha subunit interface [polypeptide binding]; other site 1009846017584 active site 1009846017585 substrate binding site [chemical binding]; other site 1009846017586 Fe binding site [ion binding]; other site 1009846017587 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1009846017588 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1009846017589 NAD binding site [chemical binding]; other site 1009846017590 catalytic residues [active] 1009846017591 substrate binding site [chemical binding]; other site 1009846017592 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1009846017593 active site 1009846017594 catalytic triad [active] 1009846017595 oxyanion hole [active] 1009846017596 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846017597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017599 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1009846017600 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1009846017601 acyl-activating enzyme (AAE) consensus motif; other site 1009846017602 putative AMP binding site [chemical binding]; other site 1009846017603 putative active site [active] 1009846017604 putative CoA binding site [chemical binding]; other site 1009846017605 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1009846017606 putative active site pocket [active] 1009846017607 dimerization interface [polypeptide binding]; other site 1009846017608 putative catalytic residue [active] 1009846017609 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1009846017610 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1009846017611 Cache domain; Region: Cache_1; pfam02743 1009846017612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1009846017613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1009846017614 metal binding site [ion binding]; metal-binding site 1009846017615 active site 1009846017616 I-site; other site 1009846017617 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1009846017618 Nuclease-related domain; Region: NERD; pfam08378 1009846017619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1009846017620 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1009846017621 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1009846017622 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1009846017623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1009846017624 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1009846017625 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1009846017626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846017627 Walker A/P-loop; other site 1009846017628 ATP binding site [chemical binding]; other site 1009846017629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1009846017630 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1009846017631 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1009846017632 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1009846017633 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1009846017634 metal binding site [ion binding]; metal-binding site 1009846017635 putative dimer interface [polypeptide binding]; other site 1009846017636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017637 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846017638 putative substrate translocation pore; other site 1009846017639 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1009846017640 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1009846017641 Bacterial transcriptional regulator; Region: IclR; pfam01614 1009846017642 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1009846017643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1009846017644 dimer interface [polypeptide binding]; other site 1009846017645 active site 1009846017646 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1009846017647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846017648 PAS domain; Region: PAS_9; pfam13426 1009846017649 putative active site [active] 1009846017650 heme pocket [chemical binding]; other site 1009846017651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1009846017652 dimerization interface [polypeptide binding]; other site 1009846017653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846017654 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846017655 dimer interface [polypeptide binding]; other site 1009846017656 putative CheW interface [polypeptide binding]; other site 1009846017657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846017658 PAS domain; Region: PAS_9; pfam13426 1009846017659 putative active site [active] 1009846017660 heme pocket [chemical binding]; other site 1009846017661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1009846017662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1009846017663 dimer interface [polypeptide binding]; other site 1009846017664 putative CheW interface [polypeptide binding]; other site 1009846017665 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1009846017666 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1009846017667 tetramerization interface [polypeptide binding]; other site 1009846017668 NAD(P) binding site [chemical binding]; other site 1009846017669 catalytic residues [active] 1009846017670 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1009846017671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1009846017672 inhibitor-cofactor binding pocket; inhibition site 1009846017673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846017674 catalytic residue [active] 1009846017675 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1009846017676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1009846017677 DNA-binding site [nucleotide binding]; DNA binding site 1009846017678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1009846017679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1009846017680 homodimer interface [polypeptide binding]; other site 1009846017681 catalytic residue [active] 1009846017682 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1009846017683 selenophosphate synthetase; Provisional; Region: PRK00943 1009846017684 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1009846017685 dimerization interface [polypeptide binding]; other site 1009846017686 putative ATP binding site [chemical binding]; other site 1009846017687 LysE type translocator; Region: LysE; cl00565 1009846017688 Purine nucleoside permease (NUP); Region: NUP; pfam06516 1009846017689 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1009846017690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846017691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017692 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1009846017693 putative effector binding pocket; other site 1009846017694 putative dimerization interface [polypeptide binding]; other site 1009846017695 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1009846017696 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1009846017697 substrate binding pocket [chemical binding]; other site 1009846017698 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1009846017699 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1009846017700 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1009846017701 HlyD family secretion protein; Region: HlyD_3; pfam13437 1009846017702 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1009846017703 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1009846017704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1009846017705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1009846017706 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1009846017707 dimerization interface [polypeptide binding]; other site 1009846017708 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846017709 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1009846017710 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1009846017711 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1009846017712 catalytic site [active] 1009846017713 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 1009846017714 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1009846017715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1009846017716 active site 1009846017717 phosphorylation site [posttranslational modification] 1009846017718 intermolecular recognition site; other site 1009846017719 dimerization interface [polypeptide binding]; other site 1009846017720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1009846017721 Walker A motif; other site 1009846017722 ATP binding site [chemical binding]; other site 1009846017723 Walker B motif; other site 1009846017724 arginine finger; other site 1009846017725 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1009846017726 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1009846017727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1009846017728 dimer interface [polypeptide binding]; other site 1009846017729 phosphorylation site [posttranslational modification] 1009846017730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1009846017731 ATP binding site [chemical binding]; other site 1009846017732 Mg2+ binding site [ion binding]; other site 1009846017733 G-X-G motif; other site 1009846017734 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1009846017735 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1009846017736 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1009846017737 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1009846017738 active site 1009846017739 non-prolyl cis peptide bond; other site 1009846017740 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1009846017741 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1009846017742 Walker A/P-loop; other site 1009846017743 ATP binding site [chemical binding]; other site 1009846017744 Q-loop/lid; other site 1009846017745 ABC transporter signature motif; other site 1009846017746 Walker B; other site 1009846017747 D-loop; other site 1009846017748 H-loop/switch region; other site 1009846017749 NIL domain; Region: NIL; pfam09383 1009846017750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846017751 dimer interface [polypeptide binding]; other site 1009846017752 conserved gate region; other site 1009846017753 ABC-ATPase subunit interface; other site 1009846017754 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1009846017755 Flavin binding site [chemical binding]; other site 1009846017756 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1009846017757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1009846017758 putative DNA binding site [nucleotide binding]; other site 1009846017759 putative Zn2+ binding site [ion binding]; other site 1009846017760 AsnC family; Region: AsnC_trans_reg; pfam01037 1009846017761 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1009846017762 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1009846017763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1009846017764 non-specific DNA binding site [nucleotide binding]; other site 1009846017765 salt bridge; other site 1009846017766 sequence-specific DNA binding site [nucleotide binding]; other site 1009846017767 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 1009846017768 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1009846017769 Peptidase family M50; Region: Peptidase_M50; pfam02163 1009846017770 active site 1009846017771 putative substrate binding region [chemical binding]; other site 1009846017772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017773 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846017774 putative substrate translocation pore; other site 1009846017775 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1009846017776 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1009846017777 dimer interface [polypeptide binding]; other site 1009846017778 NADP binding site [chemical binding]; other site 1009846017779 catalytic residues [active] 1009846017780 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1009846017781 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1009846017782 putative active site [active] 1009846017783 catalytic residue [active] 1009846017784 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1009846017785 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1009846017786 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1009846017787 SnoaL-like domain; Region: SnoaL_2; pfam12680 1009846017788 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1009846017789 Predicted membrane protein [Function unknown]; Region: COG2259 1009846017790 metabolite-proton symporter; Region: 2A0106; TIGR00883 1009846017791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017792 putative substrate translocation pore; other site 1009846017793 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1009846017794 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1009846017795 dimerization interface [polypeptide binding]; other site 1009846017796 ligand binding site [chemical binding]; other site 1009846017797 PAS fold; Region: PAS_4; pfam08448 1009846017798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1009846017799 putative active site [active] 1009846017800 heme pocket [chemical binding]; other site 1009846017801 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1009846017802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1009846017804 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1009846017805 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1009846017806 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1009846017807 dimer interface [polypeptide binding]; other site 1009846017808 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1009846017809 active site 1009846017810 Fe binding site [ion binding]; other site 1009846017811 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1009846017812 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1009846017813 active site 1009846017814 trimer interface [polypeptide binding]; other site 1009846017815 dimer interface [polypeptide binding]; other site 1009846017816 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1009846017817 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1009846017818 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1009846017819 shikimate binding site; other site 1009846017820 NAD(P) binding site [chemical binding]; other site 1009846017821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017822 D-galactonate transporter; Region: 2A0114; TIGR00893 1009846017823 putative substrate translocation pore; other site 1009846017824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1009846017825 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1009846017826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1009846017827 catalytic residue [active] 1009846017828 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1009846017829 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1009846017830 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1009846017831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1009846017832 Walker A/P-loop; other site 1009846017833 ATP binding site [chemical binding]; other site 1009846017834 Q-loop/lid; other site 1009846017835 ABC transporter signature motif; other site 1009846017836 Walker B; other site 1009846017837 D-loop; other site 1009846017838 H-loop/switch region; other site 1009846017839 TOBE domain; Region: TOBE_2; pfam08402 1009846017840 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1009846017841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1009846017842 dimer interface [polypeptide binding]; other site 1009846017843 conserved gate region; other site 1009846017844 putative PBP binding loops; other site 1009846017845 ABC-ATPase subunit interface; other site 1009846017846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1009846017847 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1009846017848 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1009846017849 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 1009846017850 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 1009846017851 NAD(P) binding site [chemical binding]; other site 1009846017852 catalytic residues [active] 1009846017853 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276