-- dump date   	20140619_013353
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
999541000001	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
999541000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541000003	P-loop; other site
999541000004	Magnesium ion binding site [ion binding]; other site
999541000005	ParB-like nuclease domain; Region: ParB; smart00470
999541000006	Initiator Replication protein; Region: Rep_3; pfam01051
999541000007	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
999541000008	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
999541000009	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
999541000010	active site
999541000011	catalytic residues [active]
999541000012	Int/Topo IB signature motif; other site
999541000013	DNA binding site [nucleotide binding]
999541000014	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
999541000015	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541000016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541000017	non-specific DNA binding site [nucleotide binding]; other site
999541000018	salt bridge; other site
999541000019	sequence-specific DNA binding site [nucleotide binding]; other site
999541000020	Cupin domain; Region: Cupin_2; pfam07883
999541000021	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
999541000022	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
999541000023	substrate-cofactor binding pocket; other site
999541000024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541000025	catalytic residue [active]
999541000026	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
999541000027	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541000028	NAD(P) binding site [chemical binding]; other site
999541000029	putative acetyltransferase; Provisional; Region: PRK03624
999541000030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541000031	Coenzyme A binding pocket [chemical binding]; other site
999541000032	YceI-like domain; Region: YceI; smart00867
999541000033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541000034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541000035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
999541000036	SnoaL-like domain; Region: SnoaL_2; pfam12680
999541000037	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
999541000038	tartrate dehydrogenase; Region: TTC; TIGR02089
999541000039	transcriptional activator TtdR; Provisional; Region: PRK09801
999541000040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000041	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
999541000042	putative effector binding pocket; other site
999541000043	putative dimerization interface [polypeptide binding]; other site
999541000044	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
999541000045	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541000046	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541000047	DNA-binding site [nucleotide binding]; DNA binding site
999541000048	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541000049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000050	D-galactonate transporter; Region: 2A0114; TIGR00893
999541000051	putative substrate translocation pore; other site
999541000052	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
999541000053	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
999541000054	active site
999541000055	tetramer interface [polypeptide binding]; other site
999541000056	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
999541000057	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541000058	putative active site [active]
999541000059	catalytic residue [active]
999541000060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541000061	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541000062	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541000063	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
999541000064	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541000065	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
999541000066	active site
999541000067	nucleophile elbow; other site
999541000068	Patatin phospholipase; Region: DUF3734; pfam12536
999541000069	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
999541000070	classical (c) SDRs; Region: SDR_c; cd05233
999541000071	NAD(P) binding site [chemical binding]; other site
999541000072	active site
999541000073	acetoacetate decarboxylase; Provisional; Region: PRK02265
999541000074	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
999541000075	active site
999541000076	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
999541000077	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
999541000078	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
999541000079	FAD binding pocket [chemical binding]; other site
999541000080	FAD binding motif [chemical binding]; other site
999541000081	phosphate binding motif [ion binding]; other site
999541000082	NAD binding pocket [chemical binding]; other site
999541000083	Predicted transcriptional regulators [Transcription]; Region: COG1695
999541000084	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
999541000085	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541000086	DNA-binding site [nucleotide binding]; DNA binding site
999541000087	RNA-binding motif; other site
999541000088	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
999541000089	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
999541000090	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541000091	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
999541000092	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
999541000093	phosphopeptide binding site; other site
999541000094	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
999541000095	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
999541000096	ATP binding site [chemical binding]; other site
999541000097	Walker A motif; other site
999541000098	hexamer interface [polypeptide binding]; other site
999541000099	Walker B motif; other site
999541000100	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
999541000101	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541000102	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
999541000103	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541000104	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
999541000105	TadE-like protein; Region: TadE; pfam07811
999541000106	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541000107	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541000108	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541000109	catalytic residue [active]
999541000110	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000111	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000112	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000113	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000114	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000115	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000116	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000117	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000118	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000119	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000120	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000121	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000122	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000123	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
999541000124	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000125	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000126	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000127	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000128	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000129	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000130	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541000131	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
999541000132	putative active site [active]
999541000133	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
999541000134	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541000135	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
999541000136	Walker A/P-loop; other site
999541000137	ATP binding site [chemical binding]; other site
999541000138	Q-loop/lid; other site
999541000139	ABC transporter signature motif; other site
999541000140	Walker B; other site
999541000141	D-loop; other site
999541000142	H-loop/switch region; other site
999541000143	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
999541000144	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541000145	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541000146	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
999541000147	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541000148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541000149	active site
999541000150	phosphorylation site [posttranslational modification]
999541000151	intermolecular recognition site; other site
999541000152	dimerization interface [polypeptide binding]; other site
999541000153	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541000154	DNA binding residues [nucleotide binding]
999541000155	dimerization interface [polypeptide binding]; other site
999541000156	glutathionine S-transferase; Provisional; Region: PRK10542
999541000157	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
999541000158	C-terminal domain interface [polypeptide binding]; other site
999541000159	GSH binding site (G-site) [chemical binding]; other site
999541000160	dimer interface [polypeptide binding]; other site
999541000161	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
999541000162	dimer interface [polypeptide binding]; other site
999541000163	N-terminal domain interface [polypeptide binding]; other site
999541000164	substrate binding pocket (H-site) [chemical binding]; other site
999541000165	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541000166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000167	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541000168	dimerization interface [polypeptide binding]; other site
999541000169	substrate binding pocket [chemical binding]; other site
999541000170	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
999541000171	short chain dehydrogenase; Provisional; Region: PRK06500
999541000172	classical (c) SDRs; Region: SDR_c; cd05233
999541000173	NAD(P) binding site [chemical binding]; other site
999541000174	active site
999541000175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000177	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541000178	putative effector binding pocket; other site
999541000179	putative dimerization interface [polypeptide binding]; other site
999541000180	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
999541000181	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541000182	DNA-binding site [nucleotide binding]; DNA binding site
999541000183	RNA-binding motif; other site
999541000184	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
999541000185	rRNA binding site [nucleotide binding]; other site
999541000186	predicted 30S ribosome binding site; other site
999541000187	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
999541000188	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
999541000189	Cytochrome P450; Region: p450; cl12078
999541000190	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
999541000191	thiamine pyrophosphate protein; Provisional; Region: PRK08273
999541000192	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
999541000193	PYR/PP interface [polypeptide binding]; other site
999541000194	dimer interface [polypeptide binding]; other site
999541000195	tetramer interface [polypeptide binding]; other site
999541000196	TPP binding site [chemical binding]; other site
999541000197	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541000198	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
999541000199	TPP-binding site [chemical binding]; other site
999541000200	HlyD family secretion protein; Region: HlyD; pfam00529
999541000201	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541000202	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541000203	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541000204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000205	putative substrate translocation pore; other site
999541000206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000207	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
999541000208	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541000209	Cation efflux family; Region: Cation_efflux; pfam01545
999541000210	MgtC family; Region: MgtC; pfam02308
999541000211	PRC-barrel domain; Region: PRC; pfam05239
999541000212	FOG: CBS domain [General function prediction only]; Region: COG0517
999541000213	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
999541000214	Response regulator receiver domain; Region: Response_reg; pfam00072
999541000215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541000216	active site
999541000217	phosphorylation site [posttranslational modification]
999541000218	intermolecular recognition site; other site
999541000219	dimerization interface [polypeptide binding]; other site
999541000220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541000221	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541000222	Walker A motif; other site
999541000223	ATP binding site [chemical binding]; other site
999541000224	Walker B motif; other site
999541000225	arginine finger; other site
999541000226	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
999541000227	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
999541000228	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541000229	dinuclear metal binding motif [ion binding]; other site
999541000230	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
999541000231	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541000232	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541000233	active site
999541000234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541000235	Coenzyme A binding pocket [chemical binding]; other site
999541000236	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541000239	dimerization interface [polypeptide binding]; other site
999541000240	Predicted membrane protein [Function unknown]; Region: COG4125
999541000241	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
999541000242	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
999541000243	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541000244	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
999541000245	putative active site pocket [active]
999541000246	metal binding site [ion binding]; metal-binding site
999541000247	short chain dehydrogenase; Provisional; Region: PRK08628
999541000248	classical (c) SDRs; Region: SDR_c; cd05233
999541000249	NAD(P) binding site [chemical binding]; other site
999541000250	active site
999541000251	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541000252	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541000253	Walker A/P-loop; other site
999541000254	ATP binding site [chemical binding]; other site
999541000255	Q-loop/lid; other site
999541000256	ABC transporter signature motif; other site
999541000257	Walker B; other site
999541000258	D-loop; other site
999541000259	H-loop/switch region; other site
999541000260	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541000261	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541000262	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541000263	TM-ABC transporter signature motif; other site
999541000264	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
999541000265	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
999541000266	putative ligand binding site [chemical binding]; other site
999541000267	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541000268	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541000269	DNA-binding site [nucleotide binding]; DNA binding site
999541000270	FCD domain; Region: FCD; pfam07729
999541000271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541000272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541000273	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
999541000274	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541000275	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541000276	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
999541000277	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541000278	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541000279	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000281	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541000282	dimerization interface [polypeptide binding]; other site
999541000283	substrate binding pocket [chemical binding]; other site
999541000284	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
999541000285	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
999541000286	DNA binding residues [nucleotide binding]
999541000287	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541000288	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
999541000289	putative active site [active]
999541000290	putative FMN binding site [chemical binding]; other site
999541000291	putative substrate binding site [chemical binding]; other site
999541000292	putative catalytic residue [active]
999541000293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000294	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541000295	NAD(P) binding site [chemical binding]; other site
999541000296	active site
999541000297	Lysine efflux permease [General function prediction only]; Region: COG1279
999541000298	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
999541000299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000300	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541000301	dimerization interface [polypeptide binding]; other site
999541000302	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
999541000303	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541000304	ligand binding site [chemical binding]; other site
999541000305	flexible hinge region; other site
999541000306	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541000307	putative switch regulator; other site
999541000308	non-specific DNA interactions [nucleotide binding]; other site
999541000309	DNA binding site [nucleotide binding]
999541000310	sequence specific DNA binding site [nucleotide binding]; other site
999541000311	putative cAMP binding site [chemical binding]; other site
999541000312	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541000313	Ligand Binding Site [chemical binding]; other site
999541000314	Transcriptional activator HlyU; Region: HlyU; cl02273
999541000315	serine O-acetyltransferase; Region: cysE; TIGR01172
999541000316	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
999541000317	trimer interface [polypeptide binding]; other site
999541000318	active site
999541000319	substrate binding site [chemical binding]; other site
999541000320	CoA binding site [chemical binding]; other site
999541000321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000322	short chain dehydrogenase; Provisional; Region: PRK09134
999541000323	NAD(P) binding site [chemical binding]; other site
999541000324	active site
999541000325	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
999541000326	GTP cyclohydrolase I; Provisional; Region: PLN03044
999541000327	active site
999541000328	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000329	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000330	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
999541000331	substrate binding pocket [chemical binding]; other site
999541000332	dimerization interface [polypeptide binding]; other site
999541000333	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
999541000334	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541000335	Coenzyme A transferase; Region: CoA_trans; cl17247
999541000336	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
999541000337	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
999541000338	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
999541000339	tetramer interface [polypeptide binding]; other site
999541000340	active site
999541000341	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
999541000342	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
999541000343	TAP-like protein; Region: Abhydrolase_4; pfam08386
999541000344	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
999541000345	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541000346	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541000347	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541000348	non-specific DNA binding site [nucleotide binding]; other site
999541000349	salt bridge; other site
999541000350	sequence-specific DNA binding site [nucleotide binding]; other site
999541000351	HipA N-terminal domain; Region: Couple_hipA; pfam13657
999541000352	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
999541000353	HipA-like N-terminal domain; Region: HipA_N; pfam07805
999541000354	HipA-like C-terminal domain; Region: HipA_C; pfam07804
999541000355	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000356	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541000357	dimerization interface [polypeptide binding]; other site
999541000358	putative effector binding pocket; other site
999541000359	Killing trait; Region: RebB; pfam11747
999541000360	Killing trait; Region: RebB; pfam11747
999541000361	Killing trait; Region: RebB; pfam11747
999541000362	Killing trait; Region: RebB; pfam11747
999541000363	Killing trait; Region: RebB; pfam11747
999541000364	Killing trait; Region: RebB; pfam11747
999541000365	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
999541000366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541000367	Walker A motif; other site
999541000368	ATP binding site [chemical binding]; other site
999541000369	Walker B motif; other site
999541000370	arginine finger; other site
999541000371	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541000372	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541000373	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
999541000374	Sulfatase; Region: Sulfatase; cl17466
999541000375	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
999541000376	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
999541000377	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541000378	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541000379	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541000380	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541000381	Cytochrome c; Region: Cytochrom_C; pfam00034
999541000382	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
999541000383	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
999541000384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000385	putative substrate translocation pore; other site
999541000386	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
999541000387	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
999541000388	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
999541000389	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
999541000390	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
999541000391	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
999541000392	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
999541000393	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
999541000394	active site
999541000395	dimer interface [polypeptide binding]; other site
999541000396	motif 1; other site
999541000397	motif 2; other site
999541000398	motif 3; other site
999541000399	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
999541000400	anticodon binding site; other site
999541000401	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
999541000402	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
999541000403	active site
999541000404	HIGH motif; other site
999541000405	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
999541000406	KMSKS motif; other site
999541000407	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
999541000408	tRNA binding surface [nucleotide binding]; other site
999541000409	anticodon binding site; other site
999541000410	putative GTP cyclohydrolase; Provisional; Region: PRK13674
999541000411	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
999541000412	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
999541000413	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
999541000414	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
999541000415	metal binding site 2 [ion binding]; metal-binding site
999541000416	putative DNA binding helix; other site
999541000417	metal binding site 1 [ion binding]; metal-binding site
999541000418	dimer interface [polypeptide binding]; other site
999541000419	structural Zn2+ binding site [ion binding]; other site
999541000420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541000421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541000422	metal binding site [ion binding]; metal-binding site
999541000423	active site
999541000424	I-site; other site
999541000425	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
999541000426	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541000427	acyl-activating enzyme (AAE) consensus motif; other site
999541000428	AMP binding site [chemical binding]; other site
999541000429	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000430	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
999541000431	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541000432	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
999541000433	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
999541000434	active site
999541000435	catalytic triad [active]
999541000436	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
999541000437	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
999541000438	catalytic residues [active]
999541000439	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541000440	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541000441	DNA binding site [nucleotide binding]
999541000442	domain linker motif; other site
999541000443	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
999541000444	putative dimerization interface [polypeptide binding]; other site
999541000445	putative ligand binding site [chemical binding]; other site
999541000446	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
999541000447	dimer interaction site [polypeptide binding]; other site
999541000448	substrate-binding tunnel; other site
999541000449	active site
999541000450	catalytic site [active]
999541000451	substrate binding site [chemical binding]; other site
999541000452	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
999541000453	Coenzyme A transferase; Region: CoA_trans; smart00882
999541000454	Coenzyme A transferase; Region: CoA_trans; cl17247
999541000455	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541000456	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
999541000457	NAD(P) binding pocket [chemical binding]; other site
999541000458	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541000459	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541000460	putative sialic acid transporter; Region: 2A0112; TIGR00891
999541000461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000462	putative substrate translocation pore; other site
999541000463	protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367
999541000464	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
999541000465	active site
999541000466	metal binding site [ion binding]; metal-binding site
999541000467	The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923
999541000468	putative dimer interface [polypeptide binding]; other site
999541000469	putative N- and C-terminal domain interface [polypeptide binding]; other site
999541000470	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541000471	hypothetical protein; Provisional; Region: PRK09262
999541000472	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541000473	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000476	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
999541000477	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
999541000478	putative dimerization interface [polypeptide binding]; other site
999541000479	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
999541000480	Cupin; Region: Cupin_6; pfam12852
999541000481	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541000482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541000483	oxidoreductase; Provisional; Region: PRK06196
999541000484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000485	NAD(P) binding site [chemical binding]; other site
999541000486	active site
999541000487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000488	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541000489	putative substrate translocation pore; other site
999541000490	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
999541000491	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541000492	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
999541000493	shikimate binding site; other site
999541000494	NAD(P) binding site [chemical binding]; other site
999541000495	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
999541000496	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541000497	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541000498	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
999541000499	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
999541000500	tetramer interface [polypeptide binding]; other site
999541000501	active site
999541000502	Mg2+/Mn2+ binding site [ion binding]; other site
999541000503	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
999541000504	active site
999541000505	catalytic residues [active]
999541000506	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
999541000507	putative active site pocket [active]
999541000508	dimerization interface [polypeptide binding]; other site
999541000509	putative catalytic residue [active]
999541000510	DNA polymerase II; Reviewed; Region: PRK05762
999541000511	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
999541000512	active site
999541000513	catalytic site [active]
999541000514	substrate binding site [chemical binding]; other site
999541000515	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
999541000516	active site
999541000517	metal-binding site
999541000518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000520	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
999541000521	putative dimerization interface [polypeptide binding]; other site
999541000522	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541000523	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541000524	trimer interface [polypeptide binding]; other site
999541000525	eyelet of channel; other site
999541000526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000527	C factor cell-cell signaling protein; Provisional; Region: PRK09009
999541000528	NAD(P) binding site [chemical binding]; other site
999541000529	active site
999541000530	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
999541000531	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
999541000532	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
999541000533	ATP binding site [chemical binding]; other site
999541000534	Mg++ binding site [ion binding]; other site
999541000535	motif III; other site
999541000536	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541000537	nucleotide binding region [chemical binding]; other site
999541000538	ATP-binding site [chemical binding]; other site
999541000539	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
999541000540	putative RNA binding site [nucleotide binding]; other site
999541000541	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
999541000542	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541000543	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541000544	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
999541000545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000546	NAD(P) binding site [chemical binding]; other site
999541000547	active site
999541000548	Low affinity iron permease; Region: Iron_permease; pfam04120
999541000549	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541000550	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541000551	metal binding site [ion binding]; metal-binding site
999541000552	active site
999541000553	I-site; other site
999541000554	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541000555	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000556	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541000557	dimerization interface [polypeptide binding]; other site
999541000558	substrate binding pocket [chemical binding]; other site
999541000559	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
999541000560	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
999541000561	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541000562	DNA binding site [nucleotide binding]
999541000563	AAA ATPase domain; Region: AAA_16; pfam13191
999541000564	Predicted ATPase [General function prediction only]; Region: COG3903
999541000565	Tir chaperone protein (CesT) family; Region: CesT; cl08444
999541000566	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
999541000567	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
999541000568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000569	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
999541000570	nudix motif; other site
999541000571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541000572	S-adenosylmethionine binding site [chemical binding]; other site
999541000573	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
999541000574	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541000575	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541000576	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541000577	[2Fe-2S] cluster binding site [ion binding]; other site
999541000578	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
999541000579	hydrophobic ligand binding site; other site
999541000580	TPR repeat; Region: TPR_11; pfam13414
999541000581	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
999541000582	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
999541000583	dimer interface [polypeptide binding]; other site
999541000584	active site
999541000585	acyl carrier protein; Validated; Region: PRK07117
999541000586	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
999541000587	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541000588	substrate binding site [chemical binding]; other site
999541000589	oxyanion hole (OAH) forming residues; other site
999541000590	trimer interface [polypeptide binding]; other site
999541000591	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541000592	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
999541000593	substrate binding site [chemical binding]; other site
999541000594	oxyanion hole (OAH) forming residues; other site
999541000595	trimer interface [polypeptide binding]; other site
999541000596	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
999541000597	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
999541000598	dimer interface [polypeptide binding]; other site
999541000599	active site
999541000600	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541000601	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
999541000602	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
999541000603	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
999541000604	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000605	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000606	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000607	active site
999541000608	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541000609	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541000610	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541000611	putative NADP binding site [chemical binding]; other site
999541000612	active site
999541000613	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000614	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
999541000615	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541000616	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541000617	catalytic residue [active]
999541000618	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000619	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000620	active site
999541000621	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000622	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000623	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000624	active site
999541000625	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000626	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000627	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000628	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000629	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000630	active site
999541000631	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541000632	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541000633	KR domain; Region: KR; pfam08659
999541000634	putative NADP binding site [chemical binding]; other site
999541000635	active site
999541000636	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000637	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000638	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000639	active site
999541000640	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000641	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000642	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000643	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000644	active site
999541000645	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541000646	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541000647	putative NADP binding site [chemical binding]; other site
999541000648	Methyltransferase domain; Region: Methyltransf_12; pfam08242
999541000649	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541000650	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541000651	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000652	active site
999541000653	Condensation domain; Region: Condensation; pfam00668
999541000654	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541000655	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
999541000656	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541000657	acyl-activating enzyme (AAE) consensus motif; other site
999541000658	AMP binding site [chemical binding]; other site
999541000659	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000660	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541000661	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000662	active site
999541000663	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541000664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541000665	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000666	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000667	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
999541000668	active site
999541000669	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541000670	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541000671	putative NADP binding site [chemical binding]; other site
999541000672	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541000673	active site
999541000674	Methyltransferase domain; Region: Methyltransf_12; pfam08242
999541000675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000676	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000677	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000678	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
999541000679	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541000680	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541000681	catalytic residue [active]
999541000682	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541000683	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
999541000684	active site
999541000685	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
999541000686	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541000687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000688	putative substrate translocation pore; other site
999541000689	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541000690	MarR family; Region: MarR_2; pfam12802
999541000691	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
999541000692	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541000693	substrate binding site [chemical binding]; other site
999541000694	oxyanion hole (OAH) forming residues; other site
999541000695	trimer interface [polypeptide binding]; other site
999541000696	feruloyl-CoA synthase; Reviewed; Region: PRK08180
999541000697	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
999541000698	acyl-activating enzyme (AAE) consensus motif; other site
999541000699	putative AMP binding site [chemical binding]; other site
999541000700	putative active site [active]
999541000701	putative CoA binding site [chemical binding]; other site
999541000702	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
999541000703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000704	putative substrate translocation pore; other site
999541000705	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541000706	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541000707	trimer interface [polypeptide binding]; other site
999541000708	eyelet of channel; other site
999541000709	Tannase and feruloyl esterase; Region: Tannase; pfam07519
999541000710	RNA polymerase sigma factor; Provisional; Region: PRK12528
999541000711	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541000712	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541000713	DNA binding residues [nucleotide binding]
999541000714	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
999541000715	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541000716	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541000717	putative DNA binding site [nucleotide binding]; other site
999541000718	putative Zn2+ binding site [ion binding]; other site
999541000719	AsnC family; Region: AsnC_trans_reg; pfam01037
999541000720	Secretin and TonB N terminus short domain; Region: STN; smart00965
999541000721	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541000722	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541000723	N-terminal plug; other site
999541000724	ligand-binding site [chemical binding]; other site
999541000725	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
999541000726	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
999541000727	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
999541000728	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541000729	TolR protein; Region: tolR; TIGR02801
999541000730	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
999541000731	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
999541000732	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
999541000733	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
999541000734	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541000735	catalytic residues [active]
999541000736	peptidase PmbA; Provisional; Region: PRK11040
999541000737	protease TldD; Provisional; Region: tldD; PRK10735
999541000738	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
999541000739	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541000740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541000741	dimer interface [polypeptide binding]; other site
999541000742	putative CheW interface [polypeptide binding]; other site
999541000743	Predicted transporter component [General function prediction only]; Region: COG2391
999541000744	Sulphur transport; Region: Sulf_transp; pfam04143
999541000745	Predicted transporter component [General function prediction only]; Region: COG2391
999541000746	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541000747	dimerization interface [polypeptide binding]; other site
999541000748	putative DNA binding site [nucleotide binding]; other site
999541000749	putative Zn2+ binding site [ion binding]; other site
999541000750	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541000751	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541000752	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541000753	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541000754	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
999541000755	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
999541000756	active site
999541000757	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
999541000758	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541000759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000761	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541000762	dimerization interface [polypeptide binding]; other site
999541000763	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
999541000764	2-methylcitrate dehydratase; Region: prpD; TIGR02330
999541000765	Phosphotransferase enzyme family; Region: APH; pfam01636
999541000766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000767	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541000768	putative substrate translocation pore; other site
999541000769	tricarballylate dehydrogenase; Validated; Region: PRK08274
999541000770	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
999541000771	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
999541000772	type III secretion system protein YscR; Provisional; Region: PRK12797
999541000773	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
999541000774	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
999541000775	Type III secretion protein (HpaP); Region: HpaP; cl17849
999541000776	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
999541000777	FHIPEP family; Region: FHIPEP; pfam00771
999541000778	type III secretion system protein HrcU; Validated; Region: PRK09108
999541000779	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
999541000780	type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561
999541000781	Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721
999541000782	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
999541000783	type III secretion protein HrpB4; Region: HrpB4; TIGR02560
999541000784	type III secretion system protein HrpB; Validated; Region: PRK09098
999541000785	Flagellar assembly protein FliH; Region: FliH; pfam02108
999541000786	type III secretion system ATPase; Provisional; Region: PRK09099
999541000787	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
999541000788	Walker A motif/ATP binding site; other site
999541000789	Walker B motif; other site
999541000790	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
999541000791	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
999541000792	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541000793	type II secretion system protein D; Region: type_II_gspD; TIGR02517
999541000794	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541000795	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541000796	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541000797	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541000798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541000799	active site
999541000800	phosphorylation site [posttranslational modification]
999541000801	intermolecular recognition site; other site
999541000802	dimerization interface [polypeptide binding]; other site
999541000803	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541000804	DNA binding site [nucleotide binding]
999541000805	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
999541000806	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541000807	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541000808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000809	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541000810	dimerization interface [polypeptide binding]; other site
999541000811	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541000812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541000813	dimer interface [polypeptide binding]; other site
999541000814	conserved gate region; other site
999541000815	putative PBP binding loops; other site
999541000816	ABC-ATPase subunit interface; other site
999541000817	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541000818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541000819	Walker A/P-loop; other site
999541000820	ATP binding site [chemical binding]; other site
999541000821	Q-loop/lid; other site
999541000822	ABC transporter signature motif; other site
999541000823	Walker B; other site
999541000824	D-loop; other site
999541000825	H-loop/switch region; other site
999541000826	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541000827	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541000828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541000829	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
999541000830	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541000831	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541000832	eyelet of channel; other site
999541000833	trimer interface [polypeptide binding]; other site
999541000834	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
999541000835	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
999541000836	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
999541000837	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541000838	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541000839	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
999541000840	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
999541000841	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
999541000842	tetramer interface [polypeptide binding]; other site
999541000843	TPP-binding site [chemical binding]; other site
999541000844	heterodimer interface [polypeptide binding]; other site
999541000845	phosphorylation loop region [posttranslational modification]
999541000846	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
999541000847	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
999541000848	alpha subunit interface [polypeptide binding]; other site
999541000849	TPP binding site [chemical binding]; other site
999541000850	heterodimer interface [polypeptide binding]; other site
999541000851	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
999541000852	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541000853	E3 interaction surface; other site
999541000854	lipoyl attachment site [posttranslational modification]; other site
999541000855	e3 binding domain; Region: E3_binding; pfam02817
999541000856	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
999541000857	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
999541000858	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
999541000859	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541000860	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541000861	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
999541000862	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541000863	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
999541000864	DNA binding residues [nucleotide binding]
999541000865	dimerization interface [polypeptide binding]; other site
999541000866	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541000867	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541000868	acyl-activating enzyme (AAE) consensus motif; other site
999541000869	AMP binding site [chemical binding]; other site
999541000870	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541000871	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
999541000872	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541000873	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
999541000874	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
999541000875	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
999541000876	homodimer interface [polypeptide binding]; other site
999541000877	substrate-cofactor binding pocket; other site
999541000878	catalytic residue [active]
999541000879	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541000880	acetaldehyde dehydrogenase; Validated; Region: PRK08300
999541000881	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
999541000882	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
999541000883	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
999541000884	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
999541000885	active site
999541000886	catalytic residues [active]
999541000887	metal binding site [ion binding]; metal-binding site
999541000888	DmpG-like communication domain; Region: DmpG_comm; pfam07836
999541000889	Cupin domain; Region: Cupin_2; cl17218
999541000890	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541000891	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
999541000892	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
999541000893	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
999541000894	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541000895	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541000896	active site
999541000897	non-prolyl cis peptide bond; other site
999541000898	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541000899	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541000900	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
999541000901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541000902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541000903	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
999541000904	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
999541000905	Active site cavity [active]
999541000906	catalytic acid [active]
999541000907	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
999541000908	TAP-like protein; Region: Abhydrolase_4; pfam08386
999541000909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000910	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541000911	putative substrate translocation pore; other site
999541000912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541000913	Isochorismatase family; Region: Isochorismatase; pfam00857
999541000914	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
999541000915	catalytic triad [active]
999541000916	conserved cis-peptide bond; other site
999541000917	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541000918	MarR family; Region: MarR; pfam01047
999541000919	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541000920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541000921	dimer interface [polypeptide binding]; other site
999541000922	putative PBP binding loops; other site
999541000923	ABC-ATPase subunit interface; other site
999541000924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541000925	dimer interface [polypeptide binding]; other site
999541000926	conserved gate region; other site
999541000927	putative PBP binding loops; other site
999541000928	ABC-ATPase subunit interface; other site
999541000929	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541000930	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541000931	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541000932	Walker A/P-loop; other site
999541000933	ATP binding site [chemical binding]; other site
999541000934	Q-loop/lid; other site
999541000935	ABC transporter signature motif; other site
999541000936	Walker B; other site
999541000937	D-loop; other site
999541000938	H-loop/switch region; other site
999541000939	TOBE domain; Region: TOBE_2; pfam08402
999541000940	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541000941	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541000942	[2Fe-2S] cluster binding site [ion binding]; other site
999541000943	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
999541000944	putative alpha subunit interface [polypeptide binding]; other site
999541000945	putative active site [active]
999541000946	putative substrate binding site [chemical binding]; other site
999541000947	Fe binding site [ion binding]; other site
999541000948	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000949	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000950	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541000951	dimerization interface [polypeptide binding]; other site
999541000952	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
999541000953	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000955	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
999541000956	putative substrate binding pocket [chemical binding]; other site
999541000957	dimerization interface [polypeptide binding]; other site
999541000958	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541000959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541000960	substrate binding pocket [chemical binding]; other site
999541000961	membrane-bound complex binding site; other site
999541000962	hinge residues; other site
999541000963	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541000964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541000965	dimer interface [polypeptide binding]; other site
999541000966	ABC-ATPase subunit interface; other site
999541000967	putative PBP binding loops; other site
999541000968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541000969	dimer interface [polypeptide binding]; other site
999541000970	conserved gate region; other site
999541000971	putative PBP binding loops; other site
999541000972	ABC-ATPase subunit interface; other site
999541000973	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541000974	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541000975	Walker A/P-loop; other site
999541000976	ATP binding site [chemical binding]; other site
999541000977	Q-loop/lid; other site
999541000978	ABC transporter signature motif; other site
999541000979	Walker B; other site
999541000980	D-loop; other site
999541000981	H-loop/switch region; other site
999541000982	hypothetical protein; Provisional; Region: PRK07490
999541000983	intersubunit interface [polypeptide binding]; other site
999541000984	active site
999541000985	Zn2+ binding site [ion binding]; other site
999541000986	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
999541000987	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541000988	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541000989	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541000990	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000992	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541000993	putative effector binding pocket; other site
999541000994	dimerization interface [polypeptide binding]; other site
999541000995	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
999541000996	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541000997	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541000998	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
999541000999	substrate binding pocket [chemical binding]; other site
999541001000	dimerization interface [polypeptide binding]; other site
999541001001	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
999541001002	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541001003	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541001004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541001005	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
999541001006	active site
999541001007	metal binding site [ion binding]; metal-binding site
999541001008	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
999541001009	active site
999541001010	catalytic site [active]
999541001011	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541001012	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541001013	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
999541001014	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541001015	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
999541001016	shikimate binding site; other site
999541001017	NAD(P) binding site [chemical binding]; other site
999541001018	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
999541001019	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541001020	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541001021	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541001022	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541001023	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541001024	substrate binding pocket [chemical binding]; other site
999541001025	membrane-bound complex binding site; other site
999541001026	hinge residues; other site
999541001027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541001028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001029	ABC-ATPase subunit interface; other site
999541001030	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541001031	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541001032	Walker A/P-loop; other site
999541001033	ATP binding site [chemical binding]; other site
999541001034	Q-loop/lid; other site
999541001035	ABC transporter signature motif; other site
999541001036	Walker B; other site
999541001037	D-loop; other site
999541001038	H-loop/switch region; other site
999541001039	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
999541001040	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
999541001041	active site
999541001042	N-formylglutamate amidohydrolase; Region: FGase; cl01522
999541001043	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
999541001044	glutathione s-transferase; Provisional; Region: PTZ00057
999541001045	GSH binding site (G-site) [chemical binding]; other site
999541001046	C-terminal domain interface [polypeptide binding]; other site
999541001047	dimer interface [polypeptide binding]; other site
999541001048	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
999541001049	dimer interface [polypeptide binding]; other site
999541001050	N-terminal domain interface [polypeptide binding]; other site
999541001051	substrate binding pocket (H-site) [chemical binding]; other site
999541001052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541001053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541001054	dimer interface [polypeptide binding]; other site
999541001055	phosphorylation site [posttranslational modification]
999541001056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541001057	ATP binding site [chemical binding]; other site
999541001058	Mg2+ binding site [ion binding]; other site
999541001059	G-X-G motif; other site
999541001060	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541001061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541001062	active site
999541001063	phosphorylation site [posttranslational modification]
999541001064	intermolecular recognition site; other site
999541001065	dimerization interface [polypeptide binding]; other site
999541001066	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541001067	DNA binding site [nucleotide binding]
999541001068	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541001069	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541001070	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541001071	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
999541001072	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
999541001073	Helix-turn-helix; Region: HTH_3; pfam01381
999541001074	non-specific DNA binding site [nucleotide binding]; other site
999541001075	salt bridge; other site
999541001076	sequence-specific DNA binding site [nucleotide binding]; other site
999541001077	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
999541001078	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
999541001079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541001080	active site
999541001081	phosphorylation site [posttranslational modification]
999541001082	intermolecular recognition site; other site
999541001083	dimerization interface [polypeptide binding]; other site
999541001084	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
999541001085	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541001086	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541001087	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
999541001088	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541001089	dimer interface [polypeptide binding]; other site
999541001090	putative CheW interface [polypeptide binding]; other site
999541001091	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541001092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541001093	DNA binding residues [nucleotide binding]
999541001094	dimerization interface [polypeptide binding]; other site
999541001095	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
999541001096	DNA binding residues [nucleotide binding]
999541001097	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
999541001098	GAF domain; Region: GAF; pfam01590
999541001099	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
999541001100	nucleotide binding site [chemical binding]; other site
999541001101	putative NEF/HSP70 interaction site [polypeptide binding]; other site
999541001102	SBD interface [polypeptide binding]; other site
999541001103	DNA-K related protein; Region: DUF3731; pfam12531
999541001104	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
999541001105	nucleotide binding site [chemical binding]; other site
999541001106	putative NEF/HSP70 interaction site [polypeptide binding]; other site
999541001107	SBD interface [polypeptide binding]; other site
999541001108	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
999541001109	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
999541001110	NADP binding site [chemical binding]; other site
999541001111	active site
999541001112	putative substrate binding site [chemical binding]; other site
999541001113	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541001114	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
999541001115	phosphopeptide binding site; other site
999541001116	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
999541001117	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
999541001118	active site
999541001119	ATP binding site [chemical binding]; other site
999541001120	substrate binding site [chemical binding]; other site
999541001121	activation loop (A-loop); other site
999541001122	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
999541001123	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541001124	dimerization interface [polypeptide binding]; other site
999541001125	Protein of unknown function (DUF770); Region: DUF770; pfam05591
999541001126	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
999541001127	Protein of unknown function (DUF877); Region: DUF877; pfam05943
999541001128	Protein of unknown function (DUF796); Region: DUF796; pfam05638
999541001129	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
999541001130	ImpE protein; Region: ImpE; pfam07024
999541001131	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
999541001132	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
999541001133	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
999541001134	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
999541001135	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
999541001136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541001137	Walker A motif; other site
999541001138	ATP binding site [chemical binding]; other site
999541001139	Walker B motif; other site
999541001140	arginine finger; other site
999541001141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541001142	Walker A motif; other site
999541001143	ATP binding site [chemical binding]; other site
999541001144	Walker B motif; other site
999541001145	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
999541001146	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
999541001147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541001148	binding surface
999541001149	TPR motif; other site
999541001150	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
999541001151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541001152	S-adenosylmethionine binding site [chemical binding]; other site
999541001153	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
999541001154	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541001155	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541001156	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
999541001157	phosphopeptide binding site; other site
999541001158	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
999541001159	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
999541001160	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
999541001161	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541001162	ligand binding site [chemical binding]; other site
999541001163	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
999541001164	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
999541001165	G1 box; other site
999541001166	GTP/Mg2+ binding site [chemical binding]; other site
999541001167	G2 box; other site
999541001168	G3 box; other site
999541001169	Switch II region; other site
999541001170	G4 box; other site
999541001171	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
999541001172	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
999541001173	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
999541001174	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
999541001175	Protein phosphatase 2C; Region: PP2C; pfam00481
999541001176	active site
999541001177	Catalytic domain of Protein Kinases; Region: PKc; cd00180
999541001178	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
999541001179	active site
999541001180	ATP binding site [chemical binding]; other site
999541001181	substrate binding site [chemical binding]; other site
999541001182	activation loop (A-loop); other site
999541001183	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
999541001184	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
999541001185	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541001186	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
999541001187	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541001188	DNA binding residues [nucleotide binding]
999541001189	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
999541001190	putative heme binding pocket [chemical binding]; other site
999541001191	EamA-like transporter family; Region: EamA; cl17759
999541001192	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
999541001193	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541001194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541001195	non-specific DNA binding site [nucleotide binding]; other site
999541001196	salt bridge; other site
999541001197	sequence-specific DNA binding site [nucleotide binding]; other site
999541001198	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541001199	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001200	DNA-binding site [nucleotide binding]; DNA binding site
999541001201	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541001202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001203	homodimer interface [polypeptide binding]; other site
999541001204	catalytic residue [active]
999541001205	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
999541001206	homodimer interface [polypeptide binding]; other site
999541001207	catalytic residues [active]
999541001208	NAD binding site [chemical binding]; other site
999541001209	substrate binding pocket [chemical binding]; other site
999541001210	flexible flap; other site
999541001211	cell density-dependent motility repressor; Provisional; Region: PRK10082
999541001212	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001213	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541001214	dimerization interface [polypeptide binding]; other site
999541001215	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
999541001216	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541001217	aspartate racemase; Region: asp_race; TIGR00035
999541001218	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
999541001219	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
999541001220	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
999541001221	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541001222	putative metal binding site [ion binding]; other site
999541001223	homoserine dehydrogenase; Provisional; Region: PRK06270
999541001224	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
999541001225	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541001226	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541001227	[2Fe-2S] cluster binding site [ion binding]; other site
999541001228	citrate-proton symporter; Provisional; Region: PRK15075
999541001229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001230	putative substrate translocation pore; other site
999541001231	hypothetical protein; Provisional; Region: PRK07079
999541001232	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
999541001233	metal binding site [ion binding]; metal-binding site
999541001234	putative dimer interface [polypeptide binding]; other site
999541001235	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001237	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541001238	dimerization interface [polypeptide binding]; other site
999541001239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001240	D-galactonate transporter; Region: 2A0114; TIGR00893
999541001241	putative substrate translocation pore; other site
999541001242	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
999541001243	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541001244	putative ligand binding site [chemical binding]; other site
999541001245	NAD binding site [chemical binding]; other site
999541001246	catalytic site [active]
999541001247	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
999541001248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001249	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541001250	dimerization interface [polypeptide binding]; other site
999541001251	Fic family protein [Function unknown]; Region: COG3177
999541001252	Fic/DOC family; Region: Fic; pfam02661
999541001253	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541001254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001255	DNA-binding site [nucleotide binding]; DNA binding site
999541001256	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541001257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001258	homodimer interface [polypeptide binding]; other site
999541001259	catalytic residue [active]
999541001260	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
999541001261	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
999541001262	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
999541001263	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
999541001264	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
999541001265	D-pathway; other site
999541001266	Putative ubiquinol binding site [chemical binding]; other site
999541001267	Low-spin heme (heme b) binding site [chemical binding]; other site
999541001268	Putative water exit pathway; other site
999541001269	Binuclear center (heme o3/CuB) [ion binding]; other site
999541001270	K-pathway; other site
999541001271	Putative proton exit pathway; other site
999541001272	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
999541001273	Subunit I/III interface [polypeptide binding]; other site
999541001274	Subunit III/IV interface [polypeptide binding]; other site
999541001275	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
999541001276	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541001277	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001278	DNA-binding site [nucleotide binding]; DNA binding site
999541001279	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541001280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001281	homodimer interface [polypeptide binding]; other site
999541001282	catalytic residue [active]
999541001283	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
999541001284	Predicted amidohydrolase [General function prediction only]; Region: COG0388
999541001285	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
999541001286	putative active site [active]
999541001287	catalytic triad [active]
999541001288	putative dimer interface [polypeptide binding]; other site
999541001289	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
999541001290	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541001291	FeS/SAM binding site; other site
999541001292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541001293	Coenzyme A binding pocket [chemical binding]; other site
999541001294	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
999541001295	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
999541001296	dimerization interface [polypeptide binding]; other site
999541001297	putative ATP binding site [chemical binding]; other site
999541001298	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
999541001299	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
999541001300	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
999541001301	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
999541001302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541001303	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
999541001304	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
999541001305	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541001306	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541001307	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541001308	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541001309	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541001310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001311	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541001312	dimerization interface [polypeptide binding]; other site
999541001313	substrate binding pocket [chemical binding]; other site
999541001314	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541001315	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541001316	dimerization interface [polypeptide binding]; other site
999541001317	ligand binding site [chemical binding]; other site
999541001318	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
999541001319	allantoate amidohydrolase; Reviewed; Region: PRK12893
999541001320	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
999541001321	active site
999541001322	metal binding site [ion binding]; metal-binding site
999541001323	dimer interface [polypeptide binding]; other site
999541001324	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
999541001325	metal ion-dependent adhesion site (MIDAS); other site
999541001326	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
999541001327	Walker A motif; other site
999541001328	ATP binding site [chemical binding]; other site
999541001329	Walker B motif; other site
999541001330	Predicted esterase [General function prediction only]; Region: COG0400
999541001331	putative hydrolase; Provisional; Region: PRK11460
999541001332	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
999541001333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541001334	NAD(P) binding site [chemical binding]; other site
999541001335	active site
999541001336	Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576
999541001337	putative ligand binding site [chemical binding]; other site
999541001338	putative catalytic site [active]
999541001339	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
999541001340	PKC phosphorylation site [posttranslational modification]; other site
999541001341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001343	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541001344	putative effector binding pocket; other site
999541001345	dimerization interface [polypeptide binding]; other site
999541001346	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541001347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001348	putative substrate translocation pore; other site
999541001349	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
999541001350	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
999541001351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541001354	dimerization interface [polypeptide binding]; other site
999541001355	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541001356	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
999541001357	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
999541001358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001359	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001360	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541001361	putative effector binding pocket; other site
999541001362	dimerization interface [polypeptide binding]; other site
999541001363	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
999541001364	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541001365	catalytic loop [active]
999541001366	iron binding site [ion binding]; other site
999541001367	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
999541001368	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
999541001369	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541001370	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
999541001371	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541001372	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541001373	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541001374	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541001375	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541001376	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
999541001377	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
999541001378	XdhC Rossmann domain; Region: XdhC_C; pfam13478
999541001379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001381	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541001382	putative effector binding pocket; other site
999541001383	putative dimerization interface [polypeptide binding]; other site
999541001384	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541001385	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
999541001386	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541001387	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541001388	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
999541001389	Protein export membrane protein; Region: SecD_SecF; cl14618
999541001390	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541001391	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
999541001392	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
999541001393	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
999541001394	dimer interface [polypeptide binding]; other site
999541001395	active site
999541001396	glycine-pyridoxal phosphate binding site [chemical binding]; other site
999541001397	folate binding site [chemical binding]; other site
999541001398	Cupin domain; Region: Cupin_2; cl17218
999541001399	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001401	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541001402	putative effector binding pocket; other site
999541001403	putative dimerization interface [polypeptide binding]; other site
999541001404	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541001405	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541001406	active site
999541001407	catalytic tetrad [active]
999541001408	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
999541001409	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
999541001410	homodimer interface [polypeptide binding]; other site
999541001411	substrate-cofactor binding pocket; other site
999541001412	catalytic residue [active]
999541001413	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
999541001414	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541001415	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541001416	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
999541001417	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541001418	dimer interface [polypeptide binding]; other site
999541001419	active site
999541001420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541001421	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541001422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541001423	S-adenosylmethionine binding site [chemical binding]; other site
999541001424	PAS domain; Region: PAS_9; pfam13426
999541001425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541001426	putative active site [active]
999541001427	heme pocket [chemical binding]; other site
999541001428	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
999541001429	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541001430	dimer interface [polypeptide binding]; other site
999541001431	putative CheW interface [polypeptide binding]; other site
999541001432	succinic semialdehyde dehydrogenase; Region: PLN02278
999541001433	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541001434	tetramerization interface [polypeptide binding]; other site
999541001435	NAD(P) binding site [chemical binding]; other site
999541001436	catalytic residues [active]
999541001437	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
999541001438	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541001439	inhibitor-cofactor binding pocket; inhibition site
999541001440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001441	catalytic residue [active]
999541001442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001443	DNA-binding site [nucleotide binding]; DNA binding site
999541001444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541001445	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
999541001446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001447	homodimer interface [polypeptide binding]; other site
999541001448	catalytic residue [active]
999541001449	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541001450	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
999541001451	putative ligand binding site [chemical binding]; other site
999541001452	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
999541001453	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
999541001454	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
999541001455	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541001456	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541001457	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541001458	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541001459	putative DNA binding site [nucleotide binding]; other site
999541001460	putative Zn2+ binding site [ion binding]; other site
999541001461	AsnC family; Region: AsnC_trans_reg; pfam01037
999541001462	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
999541001463	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
999541001464	selenophosphate synthetase; Provisional; Region: PRK00943
999541001465	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
999541001466	dimerization interface [polypeptide binding]; other site
999541001467	putative ATP binding site [chemical binding]; other site
999541001468	Purine nucleoside permease (NUP); Region: NUP; pfam06516
999541001469	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541001470	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541001471	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541001472	inhibitor site; inhibition site
999541001473	active site
999541001474	dimer interface [polypeptide binding]; other site
999541001475	catalytic residue [active]
999541001476	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
999541001477	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
999541001478	transcriptional regulator; Provisional; Region: PRK10632
999541001479	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001480	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541001481	putative effector binding pocket; other site
999541001482	putative dimerization interface [polypeptide binding]; other site
999541001483	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
999541001484	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541001485	substrate binding pocket [chemical binding]; other site
999541001486	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541001487	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541001488	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541001489	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541001490	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541001491	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
999541001492	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541001493	Spherulation-specific family 4; Region: Spherulin4; pfam12138
999541001494	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
999541001495	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
999541001496	Flavin binding site [chemical binding]; other site
999541001497	Alginate lyase; Region: Alginate_lyase2; pfam08787
999541001498	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
999541001499	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
999541001500	N- and C-terminal domain interface [polypeptide binding]; other site
999541001501	active site
999541001502	MgATP binding site [chemical binding]; other site
999541001503	catalytic site [active]
999541001504	metal binding site [ion binding]; metal-binding site
999541001505	carbohydrate binding site [chemical binding]; other site
999541001506	putative homodimer interface [polypeptide binding]; other site
999541001507	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
999541001508	classical (c) SDRs; Region: SDR_c; cd05233
999541001509	NAD(P) binding site [chemical binding]; other site
999541001510	active site
999541001511	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
999541001512	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541001513	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541001514	TM-ABC transporter signature motif; other site
999541001515	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
999541001516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541001517	Walker A/P-loop; other site
999541001518	ATP binding site [chemical binding]; other site
999541001519	Q-loop/lid; other site
999541001520	ABC transporter signature motif; other site
999541001521	Walker B; other site
999541001522	D-loop; other site
999541001523	H-loop/switch region; other site
999541001524	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
999541001525	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
999541001526	putative ligand binding site [chemical binding]; other site
999541001527	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541001528	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541001529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001530	ferric uptake regulator; Provisional; Region: fur; PRK09462
999541001531	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
999541001532	metal binding site 2 [ion binding]; metal-binding site
999541001533	putative DNA binding helix; other site
999541001534	metal binding site 1 [ion binding]; metal-binding site
999541001535	dimer interface [polypeptide binding]; other site
999541001536	structural Zn2+ binding site [ion binding]; other site
999541001537	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541001538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541001539	active site
999541001540	phosphorylation site [posttranslational modification]
999541001541	intermolecular recognition site; other site
999541001542	dimerization interface [polypeptide binding]; other site
999541001543	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541001544	DNA binding site [nucleotide binding]
999541001545	sensor protein QseC; Provisional; Region: PRK10337
999541001546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541001547	dimer interface [polypeptide binding]; other site
999541001548	phosphorylation site [posttranslational modification]
999541001549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541001550	ATP binding site [chemical binding]; other site
999541001551	Mg2+ binding site [ion binding]; other site
999541001552	G-X-G motif; other site
999541001553	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541001554	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541001555	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541001556	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541001557	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541001558	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541001559	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
999541001560	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
999541001561	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
999541001562	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
999541001563	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541001564	N-terminal plug; other site
999541001565	ligand-binding site [chemical binding]; other site
999541001566	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541001567	Copper resistance protein D; Region: CopD; pfam05425
999541001568	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
999541001569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541001570	active site
999541001571	phosphorylation site [posttranslational modification]
999541001572	intermolecular recognition site; other site
999541001573	dimerization interface [polypeptide binding]; other site
999541001574	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541001575	DNA binding site [nucleotide binding]
999541001576	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
999541001577	dimerization interface [polypeptide binding]; other site
999541001578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541001579	dimer interface [polypeptide binding]; other site
999541001580	phosphorylation site [posttranslational modification]
999541001581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541001582	ATP binding site [chemical binding]; other site
999541001583	Mg2+ binding site [ion binding]; other site
999541001584	G-X-G motif; other site
999541001585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001586	D-galactonate transporter; Region: 2A0114; TIGR00893
999541001587	putative substrate translocation pore; other site
999541001588	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
999541001589	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
999541001590	dimer interface [polypeptide binding]; other site
999541001591	NADP binding site [chemical binding]; other site
999541001592	catalytic residues [active]
999541001593	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
999541001594	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
999541001595	active site
999541001596	HIGH motif; other site
999541001597	dimer interface [polypeptide binding]; other site
999541001598	KMSKS motif; other site
999541001599	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541001600	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
999541001601	ligand binding site [chemical binding]; other site
999541001602	dimer interface [polypeptide binding]; other site
999541001603	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541001604	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541001605	trimer interface [polypeptide binding]; other site
999541001606	eyelet of channel; other site
999541001607	choline dehydrogenase; Validated; Region: PRK02106
999541001608	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541001609	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541001610	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
999541001611	active site pocket [active]
999541001612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001613	putative substrate translocation pore; other site
999541001614	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
999541001615	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
999541001616	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541001617	NAD binding site [chemical binding]; other site
999541001618	catalytic residues [active]
999541001619	substrate binding site [chemical binding]; other site
999541001620	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541001621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001622	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541001623	dimerization interface [polypeptide binding]; other site
999541001624	substrate binding pocket [chemical binding]; other site
999541001625	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
999541001626	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541001627	putative active site [active]
999541001628	catalytic residue [active]
999541001629	galactarate dehydratase; Region: galactar-dH20; TIGR03248
999541001630	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
999541001631	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
999541001632	Predicted membrane protein [Function unknown]; Region: COG2259
999541001633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001634	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541001635	putative substrate translocation pore; other site
999541001636	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541001637	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541001638	dimerization interface [polypeptide binding]; other site
999541001639	ligand binding site [chemical binding]; other site
999541001640	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
999541001641	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
999541001642	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541001643	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
999541001644	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
999541001645	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541001646	PAS fold; Region: PAS_4; pfam08448
999541001647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541001648	putative active site [active]
999541001649	heme pocket [chemical binding]; other site
999541001650	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541001651	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001652	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
999541001653	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
999541001654	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
999541001655	dimer interface [polypeptide binding]; other site
999541001656	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
999541001657	active site
999541001658	Fe binding site [ion binding]; other site
999541001659	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
999541001660	Dehydroquinase class II; Region: DHquinase_II; pfam01220
999541001661	active site
999541001662	trimer interface [polypeptide binding]; other site
999541001663	dimer interface [polypeptide binding]; other site
999541001664	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
999541001665	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541001666	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
999541001667	shikimate binding site; other site
999541001668	NAD(P) binding site [chemical binding]; other site
999541001669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001670	D-galactonate transporter; Region: 2A0114; TIGR00893
999541001671	putative substrate translocation pore; other site
999541001672	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
999541001673	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541001674	catalytic residue [active]
999541001675	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
999541001676	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541001677	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
999541001678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541001679	Walker A/P-loop; other site
999541001680	ATP binding site [chemical binding]; other site
999541001681	Q-loop/lid; other site
999541001682	ABC transporter signature motif; other site
999541001683	Walker B; other site
999541001684	D-loop; other site
999541001685	H-loop/switch region; other site
999541001686	TOBE domain; Region: TOBE_2; pfam08402
999541001687	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
999541001688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001689	dimer interface [polypeptide binding]; other site
999541001690	conserved gate region; other site
999541001691	putative PBP binding loops; other site
999541001692	ABC-ATPase subunit interface; other site
999541001693	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541001694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001695	conserved gate region; other site
999541001696	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
999541001697	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
999541001698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541001699	Zn2+ binding site [ion binding]; other site
999541001700	Mg2+ binding site [ion binding]; other site
999541001701	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
999541001702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001703	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541001704	putative substrate translocation pore; other site
999541001705	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
999541001706	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
999541001707	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
999541001708	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
999541001709	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541001710	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001711	DNA-binding site [nucleotide binding]; DNA binding site
999541001712	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541001713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541001714	homodimer interface [polypeptide binding]; other site
999541001715	catalytic residue [active]
999541001716	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541001717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001718	putative substrate translocation pore; other site
999541001719	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
999541001720	agmatinase; Region: agmatinase; TIGR01230
999541001721	oligomer interface [polypeptide binding]; other site
999541001722	putative active site [active]
999541001723	Mn binding site [ion binding]; other site
999541001724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541001727	dimerization interface [polypeptide binding]; other site
999541001728	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541001729	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541001730	dimerization interface [polypeptide binding]; other site
999541001731	putative DNA binding site [nucleotide binding]; other site
999541001732	putative Zn2+ binding site [ion binding]; other site
999541001733	AsnC family; Region: AsnC_trans_reg; pfam01037
999541001734	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541001735	Protein of unknown function (DUF971); Region: DUF971; cl01414
999541001736	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
999541001737	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
999541001738	substrate binding pocket [chemical binding]; other site
999541001739	active site
999541001740	iron coordination sites [ion binding]; other site
999541001741	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541001742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541001744	dimerization interface [polypeptide binding]; other site
999541001745	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
999541001746	peptidase domain interface [polypeptide binding]; other site
999541001747	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
999541001748	active site
999541001749	catalytic triad [active]
999541001750	calcium binding site [ion binding]; other site
999541001751	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
999541001752	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
999541001753	amidase; Provisional; Region: PRK08137
999541001754	Amidase; Region: Amidase; cl11426
999541001755	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541001756	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541001757	trimer interface [polypeptide binding]; other site
999541001758	eyelet of channel; other site
999541001759	LysE type translocator; Region: LysE; cl00565
999541001760	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
999541001761	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
999541001762	homodimer interface [polypeptide binding]; other site
999541001763	NAD binding pocket [chemical binding]; other site
999541001764	ATP binding pocket [chemical binding]; other site
999541001765	Mg binding site [ion binding]; other site
999541001766	active-site loop [active]
999541001767	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
999541001768	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
999541001769	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541001770	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541001771	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
999541001772	putative active site [active]
999541001773	catalytic site [active]
999541001774	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
999541001775	putative active site [active]
999541001776	catalytic site [active]
999541001777	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541001778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541001779	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
999541001780	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
999541001781	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
999541001782	putative metal binding site [ion binding]; other site
999541001783	putative homodimer interface [polypeptide binding]; other site
999541001784	putative homotetramer interface [polypeptide binding]; other site
999541001785	putative homodimer-homodimer interface [polypeptide binding]; other site
999541001786	putative allosteric switch controlling residues; other site
999541001787	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541001788	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541001789	aldehyde dehydrogenase family 7 member; Region: PLN02315
999541001790	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
999541001791	tetrameric interface [polypeptide binding]; other site
999541001792	NAD binding site [chemical binding]; other site
999541001793	catalytic residues [active]
999541001794	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541001795	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541001796	DNA binding site [nucleotide binding]
999541001797	domain linker motif; other site
999541001798	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
999541001799	putative dimerization interface [polypeptide binding]; other site
999541001800	putative ligand binding site [chemical binding]; other site
999541001801	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
999541001802	active site
999541001803	phosphorylation site [posttranslational modification]
999541001804	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
999541001805	dimerization domain swap beta strand [polypeptide binding]; other site
999541001806	regulatory protein interface [polypeptide binding]; other site
999541001807	active site
999541001808	regulatory phosphorylation site [posttranslational modification]; other site
999541001809	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
999541001810	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
999541001811	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
999541001812	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
999541001813	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
999541001814	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
999541001815	putative substrate binding site [chemical binding]; other site
999541001816	putative ATP binding site [chemical binding]; other site
999541001817	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
999541001818	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
999541001819	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
999541001820	active site
999541001821	P-loop; other site
999541001822	phosphorylation site [posttranslational modification]
999541001823	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
999541001824	benzoate transport; Region: 2A0115; TIGR00895
999541001825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001826	putative substrate translocation pore; other site
999541001827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001828	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
999541001829	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
999541001830	active site
999541001831	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
999541001832	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541001833	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541001834	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541001835	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001836	short chain dehydrogenase; Provisional; Region: PRK06180
999541001837	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541001838	NADP binding site [chemical binding]; other site
999541001839	active site
999541001840	steroid binding site; other site
999541001841	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541001842	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541001843	active site
999541001844	catalytic tetrad [active]
999541001845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541001846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541001847	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541001848	putative effector binding pocket; other site
999541001849	putative dimerization interface [polypeptide binding]; other site
999541001850	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
999541001851	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541001852	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541001853	Haemagglutinin; Region: HIM; pfam05662
999541001854	YadA-like C-terminal region; Region: YadA; pfam03895
999541001855	Predicted flavoprotein [General function prediction only]; Region: COG0431
999541001856	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541001857	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
999541001858	putative substrate binding pocket [chemical binding]; other site
999541001859	AC domain interface; other site
999541001860	catalytic triad [active]
999541001861	AB domain interface; other site
999541001862	interchain disulfide; other site
999541001863	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
999541001864	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
999541001865	Walker A/P-loop; other site
999541001866	ATP binding site [chemical binding]; other site
999541001867	Q-loop/lid; other site
999541001868	ABC transporter signature motif; other site
999541001869	Walker B; other site
999541001870	D-loop; other site
999541001871	H-loop/switch region; other site
999541001872	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541001873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001874	dimer interface [polypeptide binding]; other site
999541001875	conserved gate region; other site
999541001876	putative PBP binding loops; other site
999541001877	ABC-ATPase subunit interface; other site
999541001878	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541001879	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541001880	conserved cys residue [active]
999541001881	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001883	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
999541001884	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
999541001885	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
999541001886	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
999541001887	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
999541001888	hypothetical protein; Provisional; Region: PRK05409
999541001889	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541001890	Predicted membrane protein [Function unknown]; Region: COG2259
999541001891	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
999541001892	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541001893	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
999541001894	putative NAD(P) binding site [chemical binding]; other site
999541001895	active site
999541001896	putative substrate binding site [chemical binding]; other site
999541001897	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
999541001898	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541001899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001900	putative substrate translocation pore; other site
999541001901	putative aldolase; Validated; Region: PRK08130
999541001902	intersubunit interface [polypeptide binding]; other site
999541001903	active site
999541001904	Zn2+ binding site [ion binding]; other site
999541001905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
999541001906	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541001907	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541001908	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541001909	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001910	DNA-binding site [nucleotide binding]; DNA binding site
999541001911	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541001912	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
999541001913	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541001914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
999541001915	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
999541001916	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541001917	Coenzyme A binding pocket [chemical binding]; other site
999541001918	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541001919	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541001920	non-specific DNA binding site [nucleotide binding]; other site
999541001921	salt bridge; other site
999541001922	sequence-specific DNA binding site [nucleotide binding]; other site
999541001923	Cupin domain; Region: Cupin_2; pfam07883
999541001924	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
999541001925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001926	dimer interface [polypeptide binding]; other site
999541001927	conserved gate region; other site
999541001928	putative PBP binding loops; other site
999541001929	ABC-ATPase subunit interface; other site
999541001930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541001931	dimer interface [polypeptide binding]; other site
999541001932	conserved gate region; other site
999541001933	putative PBP binding loops; other site
999541001934	ABC-ATPase subunit interface; other site
999541001935	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
999541001936	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
999541001937	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
999541001938	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
999541001939	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
999541001940	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
999541001941	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
999541001942	Walker A/P-loop; other site
999541001943	ATP binding site [chemical binding]; other site
999541001944	Q-loop/lid; other site
999541001945	ABC transporter signature motif; other site
999541001946	Walker B; other site
999541001947	D-loop; other site
999541001948	H-loop/switch region; other site
999541001949	TOBE domain; Region: TOBE; pfam03459
999541001950	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541001951	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541001952	DNA binding site [nucleotide binding]
999541001953	domain linker motif; other site
999541001954	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
999541001955	dimerization interface [polypeptide binding]; other site
999541001956	ligand binding site [chemical binding]; other site
999541001957	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
999541001958	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541001959	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541001960	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541001961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541001962	putative substrate translocation pore; other site
999541001963	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541001964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541001965	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541001966	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541001967	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541001968	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541001969	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
999541001970	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
999541001971	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541001972	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541001973	DNA-binding site [nucleotide binding]; DNA binding site
999541001974	FCD domain; Region: FCD; pfam07729
999541001975	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
999541001976	Proline racemase; Region: Pro_racemase; pfam05544
999541001977	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541001978	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541001979	dimerization interface [polypeptide binding]; other site
999541001980	ligand binding site [chemical binding]; other site
999541001981	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541001982	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541001983	conserved cys residue [active]
999541001984	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541001985	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
999541001986	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
999541001987	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
999541001988	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
999541001989	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541001990	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
999541001991	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
999541001992	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
999541001993	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541001994	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
999541001995	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
999541001996	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
999541001997	active site
999541001998	CsbD-like; Region: CsbD; pfam05532
999541001999	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541002000	Ferritin-like domain; Region: Ferritin; pfam00210
999541002001	dinuclear metal binding motif [ion binding]; other site
999541002002	Cupin domain; Region: Cupin_2; cl17218
999541002003	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541002004	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002005	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
999541002006	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
999541002007	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541002008	putative C-terminal domain interface [polypeptide binding]; other site
999541002009	putative GSH binding site (G-site) [chemical binding]; other site
999541002010	putative dimer interface [polypeptide binding]; other site
999541002011	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
999541002012	putative N-terminal domain interface [polypeptide binding]; other site
999541002013	putative dimer interface [polypeptide binding]; other site
999541002014	putative substrate binding pocket (H-site) [chemical binding]; other site
999541002015	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541002016	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541002017	trimer interface [polypeptide binding]; other site
999541002018	eyelet of channel; other site
999541002019	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541002020	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541002021	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541002022	DNA-binding site [nucleotide binding]; DNA binding site
999541002023	FCD domain; Region: FCD; pfam07729
999541002024	mannonate dehydratase; Provisional; Region: PRK03906
999541002025	mannonate dehydratase; Region: uxuA; TIGR00695
999541002026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002027	D-galactonate transporter; Region: 2A0114; TIGR00893
999541002028	putative substrate translocation pore; other site
999541002029	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
999541002030	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
999541002031	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
999541002032	peptide binding site [polypeptide binding]; other site
999541002033	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
999541002034	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
999541002035	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
999541002036	nucleophilic elbow; other site
999541002037	catalytic triad; other site
999541002038	DinB superfamily; Region: DinB_2; pfam12867
999541002039	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
999541002040	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541002041	putative NAD(P) binding site [chemical binding]; other site
999541002042	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541002043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541002044	salt bridge; other site
999541002045	non-specific DNA binding site [nucleotide binding]; other site
999541002046	sequence-specific DNA binding site [nucleotide binding]; other site
999541002047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541002048	dimer interface [polypeptide binding]; other site
999541002049	conserved gate region; other site
999541002050	putative PBP binding loops; other site
999541002051	ABC-ATPase subunit interface; other site
999541002052	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541002053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541002054	Walker A/P-loop; other site
999541002055	ATP binding site [chemical binding]; other site
999541002056	Q-loop/lid; other site
999541002057	ABC transporter signature motif; other site
999541002058	Walker B; other site
999541002059	D-loop; other site
999541002060	H-loop/switch region; other site
999541002061	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541002062	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
999541002063	TOBE domain; Region: TOBE; cl01440
999541002064	molybdenum-pterin binding domain; Region: Mop; TIGR00638
999541002065	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541002066	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
999541002067	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541002068	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
999541002069	putative ligand binding site [chemical binding]; other site
999541002070	NAD binding site [chemical binding]; other site
999541002071	catalytic site [active]
999541002072	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541002073	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541002074	trimer interface [polypeptide binding]; other site
999541002075	eyelet of channel; other site
999541002076	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
999541002077	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
999541002078	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
999541002079	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
999541002080	dimer interface [polypeptide binding]; other site
999541002081	active site
999541002082	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541002083	substrate binding site [chemical binding]; other site
999541002084	catalytic residue [active]
999541002085	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
999541002086	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
999541002087	tetramer interface [polypeptide binding]; other site
999541002088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541002089	catalytic residue [active]
999541002090	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
999541002091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002092	dimerization interface [polypeptide binding]; other site
999541002093	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
999541002094	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
999541002095	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541002096	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
999541002097	Cupin; Region: Cupin_1; smart00835
999541002098	Cupin; Region: Cupin_1; smart00835
999541002099	OsmC-like protein; Region: OsmC; cl00767
999541002100	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
999541002101	benzoate transport; Region: 2A0115; TIGR00895
999541002102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002103	putative substrate translocation pore; other site
999541002104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002105	ABC-2 type transporter; Region: ABC2_membrane; cl17235
999541002106	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
999541002107	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
999541002108	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
999541002109	Walker A/P-loop; other site
999541002110	ATP binding site [chemical binding]; other site
999541002111	Q-loop/lid; other site
999541002112	ABC transporter signature motif; other site
999541002113	Walker B; other site
999541002114	D-loop; other site
999541002115	H-loop/switch region; other site
999541002116	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541002117	EamA-like transporter family; Region: EamA; pfam00892
999541002118	EamA-like transporter family; Region: EamA; pfam00892
999541002119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541002120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002122	dimerization interface [polypeptide binding]; other site
999541002123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002124	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541002125	putative substrate translocation pore; other site
999541002126	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
999541002127	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
999541002128	choline dehydrogenase; Validated; Region: PRK02106
999541002129	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541002130	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
999541002131	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
999541002132	tetrameric interface [polypeptide binding]; other site
999541002133	NAD binding site [chemical binding]; other site
999541002134	catalytic residues [active]
999541002135	transcriptional regulator BetI; Validated; Region: PRK00767
999541002136	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541002137	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
999541002138	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541002139	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
999541002140	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
999541002141	active site
999541002142	TDP-binding site; other site
999541002143	acceptor substrate-binding pocket; other site
999541002144	homodimer interface [polypeptide binding]; other site
999541002145	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541002146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002147	putative substrate translocation pore; other site
999541002148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002149	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
999541002150	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
999541002151	Ligand binding site; other site
999541002152	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541002153	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
999541002154	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541002155	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541002156	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
999541002157	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541002158	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541002159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002160	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
999541002161	putative substrate binding pocket [chemical binding]; other site
999541002162	putative dimerization interface [polypeptide binding]; other site
999541002163	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
999541002164	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541002165	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002166	dimer interface [polypeptide binding]; other site
999541002167	putative CheW interface [polypeptide binding]; other site
999541002168	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
999541002169	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541002170	DNA binding residues [nucleotide binding]
999541002171	dimerization interface [polypeptide binding]; other site
999541002172	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541002173	Winged helix-turn helix; Region: HTH_29; pfam13551
999541002174	Helix-turn-helix domain; Region: HTH_28; pfam13518
999541002175	Homeodomain-like domain; Region: HTH_32; pfam13565
999541002176	Integrase core domain; Region: rve; pfam00665
999541002177	H-NS histone family; Region: Histone_HNS; pfam00816
999541002178	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541002179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
999541002180	TPR motif; other site
999541002181	binding surface
999541002182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541002183	binding surface
999541002184	TPR motif; other site
999541002185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
999541002186	TPR motif; other site
999541002187	binding surface
999541002188	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
999541002189	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541002190	trimer interface [polypeptide binding]; other site
999541002191	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
999541002192	trimer interface [polypeptide binding]; other site
999541002193	YadA-like C-terminal region; Region: YadA; pfam03895
999541002194	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541002195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541002196	active site
999541002197	phosphorylation site [posttranslational modification]
999541002198	intermolecular recognition site; other site
999541002199	dimerization interface [polypeptide binding]; other site
999541002200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
999541002201	DNA binding site [nucleotide binding]
999541002202	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541002203	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
999541002204	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
999541002205	active site
999541002206	TDP-binding site; other site
999541002207	acceptor substrate-binding pocket; other site
999541002208	homodimer interface [polypeptide binding]; other site
999541002209	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541002210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002211	putative substrate translocation pore; other site
999541002212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002213	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
999541002214	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
999541002215	Ligand binding site; other site
999541002216	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541002217	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
999541002218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541002219	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541002220	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
999541002221	OTU-like cysteine protease; Region: OTU; pfam02338
999541002222	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
999541002223	active site
999541002224	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
999541002225	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
999541002226	NAD binding site [chemical binding]; other site
999541002227	catalytic Zn binding site [ion binding]; other site
999541002228	structural Zn binding site [ion binding]; other site
999541002229	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541002230	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541002231	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541002232	conserved cys residue [active]
999541002233	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002234	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
999541002235	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
999541002236	active site
999541002237	dimer interface [polypeptide binding]; other site
999541002238	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
999541002239	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
999541002240	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
999541002241	putative active site [active]
999541002242	putative FMN binding site [chemical binding]; other site
999541002243	putative substrate binding site [chemical binding]; other site
999541002244	putative catalytic residue [active]
999541002245	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541002246	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
999541002247	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
999541002248	4Fe-4S binding domain; Region: Fer4; cl02805
999541002249	Cysteine-rich domain; Region: CCG; pfam02754
999541002250	Cysteine-rich domain; Region: CCG; pfam02754
999541002251	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
999541002252	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
999541002253	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
999541002254	Electron transfer flavoprotein domain; Region: ETF; pfam01012
999541002255	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541002256	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541002257	[2Fe-2S] cluster binding site [ion binding]; other site
999541002258	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
999541002259	putative alpha subunit interface [polypeptide binding]; other site
999541002260	putative active site [active]
999541002261	putative substrate binding site [chemical binding]; other site
999541002262	Fe binding site [ion binding]; other site
999541002263	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
999541002264	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
999541002265	FAD binding pocket [chemical binding]; other site
999541002266	FAD binding motif [chemical binding]; other site
999541002267	phosphate binding motif [ion binding]; other site
999541002268	beta-alpha-beta structure motif; other site
999541002269	NAD binding pocket [chemical binding]; other site
999541002270	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541002271	catalytic loop [active]
999541002272	iron binding site [ion binding]; other site
999541002273	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541002274	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
999541002275	Amino acid permease; Region: AA_permease_2; pfam13520
999541002276	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
999541002277	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
999541002278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541002279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541002280	dimer interface [polypeptide binding]; other site
999541002281	conserved gate region; other site
999541002282	putative PBP binding loops; other site
999541002283	ABC-ATPase subunit interface; other site
999541002284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541002285	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541002286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541002287	Walker A/P-loop; other site
999541002288	ATP binding site [chemical binding]; other site
999541002289	Q-loop/lid; other site
999541002290	ABC transporter signature motif; other site
999541002291	Walker B; other site
999541002292	D-loop; other site
999541002293	H-loop/switch region; other site
999541002294	TOBE domain; Region: TOBE_2; pfam08402
999541002295	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
999541002296	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
999541002297	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
999541002298	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
999541002299	active site
999541002300	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
999541002301	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
999541002302	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541002303	CHASE3 domain; Region: CHASE3; pfam05227
999541002304	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541002305	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002306	dimer interface [polypeptide binding]; other site
999541002307	putative CheW interface [polypeptide binding]; other site
999541002308	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541002309	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
999541002310	Bacterial sugar transferase; Region: Bac_transf; pfam02397
999541002311	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541002312	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
999541002313	SLBB domain; Region: SLBB; pfam10531
999541002314	Low molecular weight phosphatase family; Region: LMWPc; cd00115
999541002315	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
999541002316	active site
999541002317	tyrosine kinase; Provisional; Region: PRK11519
999541002318	Chain length determinant protein; Region: Wzz; pfam02706
999541002319	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
999541002320	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541002321	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
999541002322	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
999541002323	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
999541002324	trimer interface [polypeptide binding]; other site
999541002325	active site
999541002326	substrate binding site [chemical binding]; other site
999541002327	CoA binding site [chemical binding]; other site
999541002328	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541002329	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541002330	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541002331	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457
999541002332	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
999541002333	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
999541002334	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541002335	active site
999541002336	motif I; other site
999541002337	motif II; other site
999541002338	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
999541002339	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
999541002340	Ligand binding site; other site
999541002341	oligomer interface; other site
999541002342	KpsF/GutQ family protein; Region: kpsF; TIGR00393
999541002343	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
999541002344	putative active site [active]
999541002345	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
999541002346	active site
999541002347	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
999541002348	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
999541002349	active site
999541002350	tetramer interface; other site
999541002351	Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
999541002352	H-NS histone family; Region: Histone_HNS; pfam00816
999541002353	Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187
999541002354	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541002355	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541002356	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
999541002357	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541002358	dimerization interface [polypeptide binding]; other site
999541002359	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002360	dimer interface [polypeptide binding]; other site
999541002361	putative CheW interface [polypeptide binding]; other site
999541002362	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
999541002363	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
999541002364	TPP-binding site [chemical binding]; other site
999541002365	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
999541002366	dimer interface [polypeptide binding]; other site
999541002367	PYR/PP interface [polypeptide binding]; other site
999541002368	TPP binding site [chemical binding]; other site
999541002369	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
999541002370	oligomerisation interface [polypeptide binding]; other site
999541002371	mobile loop; other site
999541002372	roof hairpin; other site
999541002373	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
999541002374	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
999541002375	ring oligomerisation interface [polypeptide binding]; other site
999541002376	ATP/Mg binding site [chemical binding]; other site
999541002377	stacking interactions; other site
999541002378	hinge regions; other site
999541002379	MarR family; Region: MarR_2; cl17246
999541002380	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
999541002381	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541002382	catalytic residue [active]
999541002383	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541002384	MarR family; Region: MarR_2; pfam12802
999541002385	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541002386	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
999541002387	phosphate binding site [ion binding]; other site
999541002388	2-enoyl thioester reductase (ETR); Region: ETR; cd08290
999541002389	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541002390	NADP binding site [chemical binding]; other site
999541002391	dimer interface [polypeptide binding]; other site
999541002392	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541002393	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541002394	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541002395	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541002396	putative DNA binding site [nucleotide binding]; other site
999541002397	putative Zn2+ binding site [ion binding]; other site
999541002398	AsnC family; Region: AsnC_trans_reg; pfam01037
999541002399	hypothetical protein; Provisional; Region: PRK05965
999541002400	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541002401	inhibitor-cofactor binding pocket; inhibition site
999541002402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541002403	catalytic residue [active]
999541002404	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
999541002405	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
999541002406	putative ligand binding site [chemical binding]; other site
999541002407	NAD binding site [chemical binding]; other site
999541002408	dimerization interface [polypeptide binding]; other site
999541002409	catalytic site [active]
999541002410	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541002411	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541002412	Coenzyme A binding pocket [chemical binding]; other site
999541002413	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
999541002414	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541002415	motif II; other site
999541002416	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
999541002417	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541002418	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002419	dimer interface [polypeptide binding]; other site
999541002420	putative CheW interface [polypeptide binding]; other site
999541002421	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
999541002422	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
999541002423	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
999541002424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541002425	dimer interface [polypeptide binding]; other site
999541002426	conserved gate region; other site
999541002427	putative PBP binding loops; other site
999541002428	ABC-ATPase subunit interface; other site
999541002429	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
999541002430	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
999541002431	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
999541002432	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541002433	Walker A/P-loop; other site
999541002434	ATP binding site [chemical binding]; other site
999541002435	Q-loop/lid; other site
999541002436	ABC transporter signature motif; other site
999541002437	Walker B; other site
999541002438	D-loop; other site
999541002439	H-loop/switch region; other site
999541002440	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541002441	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541002442	Walker A/P-loop; other site
999541002443	ATP binding site [chemical binding]; other site
999541002444	Q-loop/lid; other site
999541002445	ABC transporter signature motif; other site
999541002446	Walker B; other site
999541002447	D-loop; other site
999541002448	H-loop/switch region; other site
999541002449	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
999541002450	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541002451	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541002452	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002453	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541002454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002455	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
999541002456	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541002457	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541002458	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541002459	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541002460	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
999541002461	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541002462	NAD binding site [chemical binding]; other site
999541002463	catalytic residues [active]
999541002464	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541002465	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541002466	metal binding site [ion binding]; metal-binding site
999541002467	putative dimer interface [polypeptide binding]; other site
999541002468	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
999541002469	Chromate transporter; Region: Chromate_transp; pfam02417
999541002470	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541002471	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541002472	DNA-binding site [nucleotide binding]; DNA binding site
999541002473	FCD domain; Region: FCD; pfam07729
999541002474	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541002475	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541002476	Walker A/P-loop; other site
999541002477	ATP binding site [chemical binding]; other site
999541002478	Q-loop/lid; other site
999541002479	ABC transporter signature motif; other site
999541002480	Walker B; other site
999541002481	D-loop; other site
999541002482	H-loop/switch region; other site
999541002483	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541002484	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541002485	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541002486	TM-ABC transporter signature motif; other site
999541002487	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
999541002488	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
999541002489	putative ligand binding site [chemical binding]; other site
999541002490	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541002491	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541002492	active site
999541002493	catalytic tetrad [active]
999541002494	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
999541002495	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
999541002496	putative NAD(P) binding site [chemical binding]; other site
999541002497	catalytic Zn binding site [ion binding]; other site
999541002498	structural Zn binding site [ion binding]; other site
999541002499	altronate oxidoreductase; Provisional; Region: PRK03643
999541002500	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
999541002501	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
999541002502	galactarate dehydratase; Region: galactar-dH20; TIGR03248
999541002503	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
999541002504	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
999541002505	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
999541002506	dimer interface [polypeptide binding]; other site
999541002507	active site
999541002508	metal binding site [ion binding]; metal-binding site
999541002509	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541002510	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541002511	NAD(P) binding site [chemical binding]; other site
999541002512	catalytic residues [active]
999541002513	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
999541002514	GAF domain; Region: GAF; pfam01590
999541002515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541002516	Walker A motif; other site
999541002517	ATP binding site [chemical binding]; other site
999541002518	Walker B motif; other site
999541002519	arginine finger; other site
999541002520	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541002521	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
999541002522	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
999541002523	active site
999541002524	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
999541002525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541002526	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541002527	dimer interface [polypeptide binding]; other site
999541002528	phosphorylation site [posttranslational modification]
999541002529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541002530	ATP binding site [chemical binding]; other site
999541002531	Mg2+ binding site [ion binding]; other site
999541002532	G-X-G motif; other site
999541002533	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541002534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541002535	active site
999541002536	phosphorylation site [posttranslational modification]
999541002537	intermolecular recognition site; other site
999541002538	dimerization interface [polypeptide binding]; other site
999541002539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541002540	Walker A motif; other site
999541002541	ATP binding site [chemical binding]; other site
999541002542	Walker B motif; other site
999541002543	arginine finger; other site
999541002544	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541002545	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
999541002546	MarR family; Region: MarR_2; cl17246
999541002547	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541002548	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
999541002549	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541002550	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
999541002551	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
999541002552	transmembrane helices; other site
999541002553	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541002554	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541002555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002556	dimer interface [polypeptide binding]; other site
999541002557	putative CheW interface [polypeptide binding]; other site
999541002558	Cache domain; Region: Cache_1; pfam02743
999541002559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541002560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541002561	metal binding site [ion binding]; metal-binding site
999541002562	active site
999541002563	I-site; other site
999541002564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541002565	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
999541002566	NAD(P) binding site [chemical binding]; other site
999541002567	active site
999541002568	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541002569	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541002570	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541002571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541002572	PGAP1-like protein; Region: PGAP1; pfam07819
999541002573	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541002574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002575	amidase; Provisional; Region: PRK07235
999541002576	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
999541002577	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
999541002578	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
999541002579	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
999541002580	putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
999541002581	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
999541002582	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
999541002583	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
999541002584	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
999541002585	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
999541002586	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
999541002587	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
999541002588	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
999541002589	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
999541002590	putative active site [active]
999541002591	putative substrate binding site [chemical binding]; other site
999541002592	putative cosubstrate binding site; other site
999541002593	catalytic site [active]
999541002594	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
999541002595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002596	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541002597	dimerization interface [polypeptide binding]; other site
999541002598	substrate binding pocket [chemical binding]; other site
999541002599	choline-sulfatase; Region: chol_sulfatase; TIGR03417
999541002600	Sulfatase; Region: Sulfatase; cl17466
999541002601	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
999541002602	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
999541002603	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
999541002604	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541002605	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541002606	trimer interface [polypeptide binding]; other site
999541002607	eyelet of channel; other site
999541002608	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541002609	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541002610	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
999541002611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541002612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002614	dimerization interface [polypeptide binding]; other site
999541002615	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541002616	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541002617	conserved cys residue [active]
999541002618	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002619	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541002620	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541002621	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
999541002622	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541002623	catalytic residue [active]
999541002624	Putative phosphatase (DUF442); Region: DUF442; cl17385
999541002625	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
999541002626	SWIM zinc finger; Region: SWIM; pfam04434
999541002627	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
999541002628	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541002629	ATP binding site [chemical binding]; other site
999541002630	putative Mg++ binding site [ion binding]; other site
999541002631	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541002632	nucleotide binding region [chemical binding]; other site
999541002633	ATP-binding site [chemical binding]; other site
999541002634	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
999541002635	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
999541002636	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
999541002637	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
999541002638	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
999541002639	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541002640	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
999541002641	active site
999541002642	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541002643	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541002644	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
999541002645	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541002646	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541002647	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541002648	catalytic loop [active]
999541002649	iron binding site [ion binding]; other site
999541002650	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
999541002651	GAF domain; Region: GAF; pfam01590
999541002652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541002653	Walker A motif; other site
999541002654	ATP binding site [chemical binding]; other site
999541002655	Walker B motif; other site
999541002656	arginine finger; other site
999541002657	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541002658	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
999541002659	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541002660	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541002661	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541002662	catalytic residue [active]
999541002663	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
999541002664	TIGR02594 family protein; Region: TIGR02594
999541002665	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
999541002666	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541002667	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002668	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541002669	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541002670	active site
999541002671	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
999541002672	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
999541002673	active site
999541002674	acyl-activating enzyme (AAE) consensus motif; other site
999541002675	putative CoA binding site [chemical binding]; other site
999541002676	AMP binding site [chemical binding]; other site
999541002677	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
999541002678	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
999541002679	tetrameric interface [polypeptide binding]; other site
999541002680	NAD binding site [chemical binding]; other site
999541002681	catalytic residues [active]
999541002682	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541002683	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
999541002684	enoyl-CoA hydratase; Provisional; Region: PRK09076
999541002685	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541002686	substrate binding site [chemical binding]; other site
999541002687	oxyanion hole (OAH) forming residues; other site
999541002688	trimer interface [polypeptide binding]; other site
999541002689	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
999541002690	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541002691	substrate binding site [chemical binding]; other site
999541002692	oxyanion hole (OAH) forming residues; other site
999541002693	trimer interface [polypeptide binding]; other site
999541002694	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
999541002695	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
999541002696	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
999541002697	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
999541002698	active site
999541002699	dimer interface [polypeptide binding]; other site
999541002700	non-prolyl cis peptide bond; other site
999541002701	insertion regions; other site
999541002702	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541002703	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541002704	DNA binding residues [nucleotide binding]
999541002705	dimerization interface [polypeptide binding]; other site
999541002706	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
999541002707	Uncharacterized conserved protein [Function unknown]; Region: COG5476
999541002708	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
999541002709	MlrC C-terminus; Region: MlrC_C; pfam07171
999541002710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541002711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002712	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002713	dimerization interface [polypeptide binding]; other site
999541002714	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
999541002715	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
999541002716	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
999541002717	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541002718	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002719	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002720	dimerization interface [polypeptide binding]; other site
999541002721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541002722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541002724	dimerization interface [polypeptide binding]; other site
999541002725	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541002726	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
999541002727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541002728	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
999541002729	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
999541002730	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
999541002731	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
999541002732	active site
999541002733	catalytic residues [active]
999541002734	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
999541002735	benzoate transport; Region: 2A0115; TIGR00895
999541002736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541002738	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
999541002739	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541002740	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541002741	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541002742	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541002743	active site
999541002744	metal binding site [ion binding]; metal-binding site
999541002745	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
999541002746	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
999541002747	putative active site [active]
999541002748	Mn binding site [ion binding]; other site
999541002749	putative oligomer interface [polypeptide binding]; other site
999541002750	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541002751	Domain of unknown function (DUF336); Region: DUF336; cl01249
999541002752	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541002753	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
999541002754	DNA-binding site [nucleotide binding]; DNA binding site
999541002755	FCD domain; Region: FCD; pfam07729
999541002756	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541002757	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541002758	trimer interface [polypeptide binding]; other site
999541002759	eyelet of channel; other site
999541002760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
999541002761	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002762	dimer interface [polypeptide binding]; other site
999541002763	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
999541002764	putative CheW interface [polypeptide binding]; other site
999541002765	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
999541002766	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
999541002767	dimer interface [polypeptide binding]; other site
999541002768	TPP-binding site [chemical binding]; other site
999541002769	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
999541002770	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541002771	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541002772	putative DNA binding site [nucleotide binding]; other site
999541002773	putative Zn2+ binding site [ion binding]; other site
999541002774	AsnC family; Region: AsnC_trans_reg; pfam01037
999541002775	D-cysteine desulfhydrase; Validated; Region: PRK03910
999541002776	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
999541002777	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541002778	catalytic residue [active]
999541002779	Transglycosylase; Region: Transgly; pfam00912
999541002780	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541002781	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
999541002782	cyanate hydratase; Validated; Region: PRK02866
999541002783	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
999541002784	oligomer interface [polypeptide binding]; other site
999541002785	active site
999541002786	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
999541002787	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
999541002788	active site
999541002789	catalytic site [active]
999541002790	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
999541002791	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
999541002792	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
999541002793	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
999541002794	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
999541002795	catalytic site [active]
999541002796	active site
999541002797	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
999541002798	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
999541002799	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
999541002800	active site
999541002801	catalytic site [active]
999541002802	glycogen branching enzyme; Provisional; Region: PRK05402
999541002803	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
999541002804	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
999541002805	active site
999541002806	catalytic site [active]
999541002807	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
999541002808	trehalose synthase; Region: treS_nterm; TIGR02456
999541002809	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
999541002810	active site
999541002811	catalytic site [active]
999541002812	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
999541002813	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
999541002814	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
999541002815	active site
999541002816	catalytic site [active]
999541002817	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
999541002818	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
999541002819	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
999541002820	active site
999541002821	homodimer interface [polypeptide binding]; other site
999541002822	catalytic site [active]
999541002823	acceptor binding site [chemical binding]; other site
999541002824	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541002825	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541002826	DNA binding site [nucleotide binding]
999541002827	domain linker motif; other site
999541002828	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
999541002829	putative dimerization interface [polypeptide binding]; other site
999541002830	putative ligand binding site [chemical binding]; other site
999541002831	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
999541002832	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541002833	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541002834	DNA-binding site [nucleotide binding]; DNA binding site
999541002835	FCD domain; Region: FCD; pfam07729
999541002836	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541002837	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541002838	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
999541002839	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
999541002840	NAD binding site [chemical binding]; other site
999541002841	homotetramer interface [polypeptide binding]; other site
999541002842	homodimer interface [polypeptide binding]; other site
999541002843	active site
999541002844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541002845	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541002846	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541002847	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541002848	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541002849	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
999541002850	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
999541002851	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
999541002852	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
999541002853	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
999541002854	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
999541002855	DNA binding site [nucleotide binding]
999541002856	active site
999541002857	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
999541002858	methionine sulfoxide reductase A; Provisional; Region: PRK13014
999541002859	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
999541002860	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
999541002861	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
999541002862	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541002863	catalytic residues [active]
999541002864	methionine sulfoxide reductase B; Provisional; Region: PRK00222
999541002865	SelR domain; Region: SelR; pfam01641
999541002866	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541002867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541002868	active site
999541002869	phosphorylation site [posttranslational modification]
999541002870	intermolecular recognition site; other site
999541002871	dimerization interface [polypeptide binding]; other site
999541002872	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541002873	DNA binding site [nucleotide binding]
999541002874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541002875	dimer interface [polypeptide binding]; other site
999541002876	phosphorylation site [posttranslational modification]
999541002877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541002878	Mg2+ binding site [ion binding]; other site
999541002879	G-X-G motif; other site
999541002880	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541002881	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541002882	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
999541002883	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
999541002884	catalytic residues [active]
999541002885	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
999541002886	aromatic chitin/cellulose binding site residues [chemical binding]; other site
999541002887	Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978
999541002888	chitosan binding site [chemical binding]; other site
999541002889	catalytic residues [active]
999541002890	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
999541002891	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
999541002892	Ligand binding site; other site
999541002893	metal-binding site
999541002894	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541002895	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541002896	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
999541002897	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
999541002898	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
999541002899	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541002900	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541002901	conserved cys residue [active]
999541002902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002903	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541002904	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
999541002905	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541002906	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
999541002907	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541002908	dimerization interface [polypeptide binding]; other site
999541002909	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541002910	dimer interface [polypeptide binding]; other site
999541002911	putative CheW interface [polypeptide binding]; other site
999541002912	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541002913	ATP binding site [chemical binding]; other site
999541002914	putative Mg++ binding site [ion binding]; other site
999541002915	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541002916	nucleotide binding region [chemical binding]; other site
999541002917	ATP-binding site [chemical binding]; other site
999541002918	DEAD/H associated; Region: DEAD_assoc; pfam08494
999541002919	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541002920	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541002921	DNA binding residues [nucleotide binding]
999541002922	dimerization interface [polypeptide binding]; other site
999541002923	Predicted amidohydrolase [General function prediction only]; Region: COG0388
999541002924	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
999541002925	putative active site [active]
999541002926	catalytic triad [active]
999541002927	putative dimer interface [polypeptide binding]; other site
999541002928	amino acid transporter; Region: 2A0306; TIGR00909
999541002929	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541002930	H-NS histone family; Region: Histone_HNS; pfam00816
999541002931	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541002932	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
999541002933	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
999541002934	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
999541002935	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541002936	Class I aldolases; Region: Aldolase_Class_I; cl17187
999541002937	catalytic residue [active]
999541002938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002939	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541002940	dimerization interface [polypeptide binding]; other site
999541002941	substrate binding pocket [chemical binding]; other site
999541002942	transcriptional regulator; Provisional; Region: PRK10632
999541002943	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541002944	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541002945	putative effector binding pocket; other site
999541002946	dimerization interface [polypeptide binding]; other site
999541002947	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541002948	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541002949	NAD(P) binding site [chemical binding]; other site
999541002950	Cupin domain; Region: Cupin_2; cl17218
999541002951	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
999541002952	threonine dehydratase; Reviewed; Region: PRK09224
999541002953	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
999541002954	tetramer interface [polypeptide binding]; other site
999541002955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541002956	catalytic residue [active]
999541002957	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
999541002958	putative Ile/Val binding site [chemical binding]; other site
999541002959	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
999541002960	putative Ile/Val binding site [chemical binding]; other site
999541002961	Uncharacterized conserved protein [Function unknown]; Region: COG1739
999541002962	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
999541002963	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
999541002964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541002965	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541002966	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541002967	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541002968	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541002969	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
999541002970	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541002971	TIGR02594 family protein; Region: TIGR02594
999541002972	PAAR motif; Region: PAAR_motif; pfam05488
999541002973	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541002974	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
999541002975	SnoaL-like domain; Region: SnoaL_3; pfam13474
999541002976	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541002977	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541002978	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541002979	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541002980	trimer interface [polypeptide binding]; other site
999541002981	eyelet of channel; other site
999541002982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541002983	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
999541002984	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541002985	Coenzyme A binding pocket [chemical binding]; other site
999541002986	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541002987	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
999541002988	C-terminal domain interface [polypeptide binding]; other site
999541002989	GSH binding site (G-site) [chemical binding]; other site
999541002990	dimer interface [polypeptide binding]; other site
999541002991	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541002992	N-terminal domain interface [polypeptide binding]; other site
999541002993	dimer interface [polypeptide binding]; other site
999541002994	substrate binding pocket (H-site) [chemical binding]; other site
999541002995	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541002996	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
999541002997	FMN binding site [chemical binding]; other site
999541002998	active site
999541002999	substrate binding site [chemical binding]; other site
999541003000	catalytic residue [active]
999541003001	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541003002	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541003003	DNA binding site [nucleotide binding]
999541003004	domain linker motif; other site
999541003005	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
999541003006	putative ligand binding site [chemical binding]; other site
999541003007	putative dimerization interface [polypeptide binding]; other site
999541003008	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541003009	inhibitor site; inhibition site
999541003010	active site
999541003011	dimer interface [polypeptide binding]; other site
999541003012	catalytic residue [active]
999541003013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003014	D-galactonate transporter; Region: 2A0114; TIGR00893
999541003015	putative substrate translocation pore; other site
999541003016	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
999541003017	substrate binding site [chemical binding]; other site
999541003018	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541003019	dimer interface [polypeptide binding]; other site
999541003020	ATP binding site [chemical binding]; other site
999541003021	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541003022	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
999541003023	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
999541003024	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541003025	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
999541003026	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541003027	NAD binding site [chemical binding]; other site
999541003028	catalytic residues [active]
999541003029	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541003030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003031	dimer interface [polypeptide binding]; other site
999541003032	conserved gate region; other site
999541003033	putative PBP binding loops; other site
999541003034	ABC-ATPase subunit interface; other site
999541003035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003036	dimer interface [polypeptide binding]; other site
999541003037	conserved gate region; other site
999541003038	putative PBP binding loops; other site
999541003039	ABC-ATPase subunit interface; other site
999541003040	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541003041	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541003042	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
999541003043	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
999541003044	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541003045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541003046	Walker A/P-loop; other site
999541003047	ATP binding site [chemical binding]; other site
999541003048	Q-loop/lid; other site
999541003049	ABC transporter signature motif; other site
999541003050	Walker B; other site
999541003051	D-loop; other site
999541003052	H-loop/switch region; other site
999541003053	TOBE domain; Region: TOBE_2; pfam08402
999541003054	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
999541003055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541003057	dimerization interface [polypeptide binding]; other site
999541003058	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541003059	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541003060	N-terminal plug; other site
999541003061	ligand-binding site [chemical binding]; other site
999541003062	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
999541003063	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
999541003064	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
999541003065	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
999541003066	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
999541003067	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541003068	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541003069	N-terminal plug; other site
999541003070	ligand-binding site [chemical binding]; other site
999541003071	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541003072	homotrimer interaction site [polypeptide binding]; other site
999541003073	putative active site [active]
999541003074	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
999541003075	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541003076	Walker A/P-loop; other site
999541003077	ATP binding site [chemical binding]; other site
999541003078	Q-loop/lid; other site
999541003079	ABC transporter signature motif; other site
999541003080	Walker B; other site
999541003081	D-loop; other site
999541003082	H-loop/switch region; other site
999541003083	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
999541003084	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
999541003085	siderophore binding site; other site
999541003086	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541003087	ABC-ATPase subunit  interface; other site
999541003088	dimer interface [polypeptide binding]; other site
999541003089	putative PBP binding regions; other site
999541003090	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
999541003091	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541003092	ABC-ATPase subunit  interface; other site
999541003093	dimer interface [polypeptide binding]; other site
999541003094	putative PBP binding regions; other site
999541003095	CopC domain; Region: CopC; pfam04234
999541003096	Protein of unknown function (DUF461); Region: DUF461; pfam04314
999541003097	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
999541003098	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
999541003099	Cu(I) binding site [ion binding]; other site
999541003100	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541003101	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541003102	Walker A/P-loop; other site
999541003103	ATP binding site [chemical binding]; other site
999541003104	Q-loop/lid; other site
999541003105	ABC transporter signature motif; other site
999541003106	Walker B; other site
999541003107	D-loop; other site
999541003108	H-loop/switch region; other site
999541003109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003110	dimer interface [polypeptide binding]; other site
999541003111	conserved gate region; other site
999541003112	putative PBP binding loops; other site
999541003113	ABC-ATPase subunit interface; other site
999541003114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003115	dimer interface [polypeptide binding]; other site
999541003116	conserved gate region; other site
999541003117	putative PBP binding loops; other site
999541003118	ABC-ATPase subunit interface; other site
999541003119	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541003120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541003121	substrate binding pocket [chemical binding]; other site
999541003122	membrane-bound complex binding site; other site
999541003123	hinge residues; other site
999541003124	RNA polymerase sigma factor; Provisional; Region: PRK12528
999541003125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541003126	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541003127	DNA binding residues [nucleotide binding]
999541003128	fec operon regulator FecR; Reviewed; Region: PRK09774
999541003129	FecR protein; Region: FecR; pfam04773
999541003130	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
999541003131	Cytochrome c; Region: Cytochrom_C; pfam00034
999541003132	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541003133	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541003134	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541003135	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
999541003136	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
999541003137	active site
999541003138	NAD binding site [chemical binding]; other site
999541003139	metal binding site [ion binding]; metal-binding site
999541003140	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
999541003141	putative dimer interface [polypeptide binding]; other site
999541003142	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541003143	ligand binding site [chemical binding]; other site
999541003144	Zn binding site [ion binding]; other site
999541003145	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
999541003146	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
999541003147	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
999541003148	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541003149	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541003150	metal binding site [ion binding]; metal-binding site
999541003151	active site
999541003152	I-site; other site
999541003153	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541003154	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541003155	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541003156	N-terminal plug; other site
999541003157	ligand-binding site [chemical binding]; other site
999541003158	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541003159	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
999541003160	Walker A/P-loop; other site
999541003161	ATP binding site [chemical binding]; other site
999541003162	Q-loop/lid; other site
999541003163	ABC transporter signature motif; other site
999541003164	Walker B; other site
999541003165	D-loop; other site
999541003166	H-loop/switch region; other site
999541003167	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
999541003168	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
999541003169	putative ligand binding residues [chemical binding]; other site
999541003170	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541003171	dimer interface [polypeptide binding]; other site
999541003172	putative PBP binding regions; other site
999541003173	ABC-ATPase subunit  interface; other site
999541003174	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
999541003175	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541003176	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541003177	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
999541003178	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541003179	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
999541003180	putative cation:proton antiport protein; Provisional; Region: PRK10669
999541003181	TrkA-N domain; Region: TrkA_N; pfam02254
999541003182	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
999541003183	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
999541003184	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
999541003185	Isochorismatase family; Region: Isochorismatase; pfam00857
999541003186	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
999541003187	catalytic triad [active]
999541003188	conserved cis-peptide bond; other site
999541003189	aspartate carbamoyltransferase; Provisional; Region: PRK11891
999541003190	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
999541003191	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
999541003192	Predicted small secreted protein [Function unknown]; Region: COG5510
999541003193	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
999541003194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541003197	dimerization interface [polypeptide binding]; other site
999541003198	malic enzyme; Reviewed; Region: PRK12861
999541003199	Malic enzyme, N-terminal domain; Region: malic; pfam00390
999541003200	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
999541003201	putative NAD(P) binding site [chemical binding]; other site
999541003202	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
999541003203	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
999541003204	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
999541003205	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541003206	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
999541003207	FMN binding site [chemical binding]; other site
999541003208	active site
999541003209	substrate binding site [chemical binding]; other site
999541003210	catalytic residue [active]
999541003211	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541003212	putative DNA binding site [nucleotide binding]; other site
999541003213	dimerization interface [polypeptide binding]; other site
999541003214	putative Zn2+ binding site [ion binding]; other site
999541003215	Condensation domain; Region: Condensation; pfam00668
999541003216	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541003217	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003218	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541003219	acyl-activating enzyme (AAE) consensus motif; other site
999541003220	AMP binding site [chemical binding]; other site
999541003221	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003222	Condensation domain; Region: Condensation; pfam00668
999541003223	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541003224	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003225	acyl-activating enzyme (AAE) consensus motif; other site
999541003226	AMP binding site [chemical binding]; other site
999541003227	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003228	Condensation domain; Region: Condensation; pfam00668
999541003229	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003230	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541003231	acyl-activating enzyme (AAE) consensus motif; other site
999541003232	AMP binding site [chemical binding]; other site
999541003233	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003234	Condensation domain; Region: Condensation; pfam00668
999541003235	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003236	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541003237	acyl-activating enzyme (AAE) consensus motif; other site
999541003238	AMP binding site [chemical binding]; other site
999541003239	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003240	Condensation domain; Region: Condensation; pfam00668
999541003241	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541003242	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541003243	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
999541003244	acyl-activating enzyme (AAE) consensus motif; other site
999541003245	AMP binding site [chemical binding]; other site
999541003246	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003247	Condensation domain; Region: Condensation; pfam00668
999541003248	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003249	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541003250	acyl-activating enzyme (AAE) consensus motif; other site
999541003251	AMP binding site [chemical binding]; other site
999541003252	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003253	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
999541003254	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541003255	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541003256	acyl-activating enzyme (AAE) consensus motif; other site
999541003257	AMP binding site [chemical binding]; other site
999541003258	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541003259	Cupin domain; Region: Cupin_2; cl17218
999541003260	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
999541003261	HD domain; Region: HD_5; pfam13487
999541003262	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541003263	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541003264	DNA binding residues [nucleotide binding]
999541003265	dimerization interface [polypeptide binding]; other site
999541003266	SnoaL-like domain; Region: SnoaL_4; pfam13577
999541003267	Chitinase A, N-terminal domain; Region: ChitinaseA_N; pfam08329
999541003268	Glyco_18 domain; Region: Glyco_18; smart00636
999541003269	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
999541003270	active site
999541003271	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
999541003272	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
999541003273	aromatic chitin/cellulose binding site residues [chemical binding]; other site
999541003274	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541003275	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541003276	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541003277	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541003278	catalytic residue [active]
999541003279	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
999541003280	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541003281	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541003282	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
999541003283	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
999541003284	Walker A motif; other site
999541003285	ATP binding site [chemical binding]; other site
999541003286	Walker B motif; other site
999541003287	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
999541003288	Secretin and TonB N terminus short domain; Region: STN; smart00965
999541003289	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541003290	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541003291	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
999541003292	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
999541003293	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541003294	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541003295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541003296	active site
999541003297	phosphorylation site [posttranslational modification]
999541003298	intermolecular recognition site; other site
999541003299	dimerization interface [polypeptide binding]; other site
999541003300	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541003301	DNA binding site [nucleotide binding]
999541003302	CHASE2 domain; Region: CHASE2; pfam05226
999541003303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541003304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541003305	dimer interface [polypeptide binding]; other site
999541003306	phosphorylation site [posttranslational modification]
999541003307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541003308	ATP binding site [chemical binding]; other site
999541003309	Mg2+ binding site [ion binding]; other site
999541003310	G-X-G motif; other site
999541003311	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
999541003312	oxidoreductase; Provisional; Region: PRK06128
999541003313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541003314	NAD(P) binding site [chemical binding]; other site
999541003315	active site
999541003316	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003318	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
999541003319	putative dimerization interface [polypeptide binding]; other site
999541003320	TPR repeat; Region: TPR_11; pfam13414
999541003321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541003322	binding surface
999541003323	TPR motif; other site
999541003324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541003325	binding surface
999541003326	TPR motif; other site
999541003327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
999541003328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541003329	binding surface
999541003330	TPR motif; other site
999541003331	Tetratricopeptide repeat; Region: TPR_12; pfam13424
999541003332	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003333	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003334	trimer interface [polypeptide binding]; other site
999541003335	eyelet of channel; other site
999541003336	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
999541003337	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
999541003338	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541003339	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
999541003340	FOG: CBS domain [General function prediction only]; Region: COG0517
999541003341	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
999541003342	dimerization interface [polypeptide binding]; other site
999541003343	active site
999541003344	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541003345	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541003346	non-specific DNA binding site [nucleotide binding]; other site
999541003347	salt bridge; other site
999541003348	sequence-specific DNA binding site [nucleotide binding]; other site
999541003349	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541003350	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541003351	DNA-binding site [nucleotide binding]; DNA binding site
999541003352	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541003353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541003354	homodimer interface [polypeptide binding]; other site
999541003355	catalytic residue [active]
999541003356	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003357	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003358	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541003359	dimerization interface [polypeptide binding]; other site
999541003360	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
999541003361	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
999541003362	Autoinducer synthetase; Region: Autoind_synth; cl17404
999541003363	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
999541003364	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541003365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541003366	DNA binding residues [nucleotide binding]
999541003367	dimerization interface [polypeptide binding]; other site
999541003368	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
999541003369	MgtC family; Region: MgtC; pfam02308
999541003370	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
999541003371	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
999541003372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541003373	DNA binding residues [nucleotide binding]
999541003374	Cupin domain; Region: Cupin_2; cl17218
999541003375	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541003376	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
999541003377	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003378	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003379	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
999541003380	putative dimerization interface [polypeptide binding]; other site
999541003381	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541003382	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541003383	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
999541003384	active site
999541003385	catalytic residues [active]
999541003386	metal binding site [ion binding]; metal-binding site
999541003387	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541003388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003389	putative substrate translocation pore; other site
999541003390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003391	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003392	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003393	trimer interface [polypeptide binding]; other site
999541003394	eyelet of channel; other site
999541003395	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
999541003396	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
999541003397	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
999541003398	putative active site [active]
999541003399	putative catalytic site [active]
999541003400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003401	D-galactonate transporter; Region: 2A0114; TIGR00893
999541003402	putative substrate translocation pore; other site
999541003403	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
999541003404	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541003405	putative active site [active]
999541003406	putative metal binding site [ion binding]; other site
999541003407	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
999541003408	putative FMN binding site [chemical binding]; other site
999541003409	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
999541003410	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541003411	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541003412	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541003413	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541003414	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003415	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003416	trimer interface [polypeptide binding]; other site
999541003417	eyelet of channel; other site
999541003418	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
999541003419	[2Fe-2S] cluster binding site [ion binding]; other site
999541003420	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541003421	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
999541003422	iron-sulfur cluster [ion binding]; other site
999541003423	[2Fe-2S] cluster binding site [ion binding]; other site
999541003424	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
999541003425	hydrophobic ligand binding site; other site
999541003426	short chain dehydrogenase; Provisional; Region: PRK12939
999541003427	classical (c) SDRs; Region: SDR_c; cd05233
999541003428	NAD(P) binding site [chemical binding]; other site
999541003429	active site
999541003430	Cupin domain; Region: Cupin_2; pfam07883
999541003431	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
999541003432	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
999541003433	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541003434	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541003435	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541003436	short chain dehydrogenase; Provisional; Region: PRK07062
999541003437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541003438	NAD(P) binding site [chemical binding]; other site
999541003439	active site
999541003440	hypothetical protein; Provisional; Region: PRK07064
999541003441	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541003442	PYR/PP interface [polypeptide binding]; other site
999541003443	dimer interface [polypeptide binding]; other site
999541003444	TPP binding site [chemical binding]; other site
999541003445	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541003446	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
999541003447	TPP-binding site [chemical binding]; other site
999541003448	L-aspartate dehydrogenase; Provisional; Region: PRK13303
999541003449	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
999541003450	Domain of unknown function DUF108; Region: DUF108; pfam01958
999541003451	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
999541003452	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
999541003453	NAD(P) binding site [chemical binding]; other site
999541003454	catalytic residues [active]
999541003455	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541003456	active site
999541003457	metal binding site [ion binding]; metal-binding site
999541003458	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
999541003459	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541003460	putative active site [active]
999541003461	putative metal binding site [ion binding]; other site
999541003462	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
999541003463	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541003464	benzoate transport; Region: 2A0115; TIGR00895
999541003465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003466	putative substrate translocation pore; other site
999541003467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003468	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541003469	Ligand Binding Site [chemical binding]; other site
999541003470	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541003471	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541003472	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541003473	hypothetical protein; Validated; Region: PRK08238
999541003474	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
999541003475	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
999541003476	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
999541003477	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541003478	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541003479	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541003480	amidase; Provisional; Region: PRK07486
999541003481	Amidase; Region: Amidase; cl11426
999541003482	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
999541003483	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541003484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541003485	putative DNA binding site [nucleotide binding]; other site
999541003486	putative Zn2+ binding site [ion binding]; other site
999541003487	AsnC family; Region: AsnC_trans_reg; pfam01037
999541003488	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541003489	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
999541003490	active site 1 [active]
999541003491	dimer interface [polypeptide binding]; other site
999541003492	hexamer interface [polypeptide binding]; other site
999541003493	active site 2 [active]
999541003494	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
999541003495	active site
999541003496	intersubunit interface [polypeptide binding]; other site
999541003497	Zn2+ binding site [ion binding]; other site
999541003498	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
999541003499	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541003500	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
999541003501	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
999541003502	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
999541003503	short chain dehydrogenase; Provisional; Region: PRK07832
999541003504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541003505	NAD(P) binding site [chemical binding]; other site
999541003506	active site
999541003507	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
999541003508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
999541003509	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003510	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003511	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541003512	putative effector binding pocket; other site
999541003513	putative dimerization interface [polypeptide binding]; other site
999541003514	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
999541003515	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
999541003516	nucleotide binding site [chemical binding]; other site
999541003517	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
999541003518	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
999541003519	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
999541003520	Cache domain; Region: Cache_2; pfam08269
999541003521	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541003522	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541003523	dimer interface [polypeptide binding]; other site
999541003524	putative CheW interface [polypeptide binding]; other site
999541003525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003526	D-galactonate transporter; Region: 2A0114; TIGR00893
999541003527	putative substrate translocation pore; other site
999541003528	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
999541003529	Uncharacterized conserved protein [Function unknown]; Region: COG4104
999541003530	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
999541003531	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
999541003532	galactarate dehydratase; Region: galactar-dH20; TIGR03248
999541003533	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
999541003534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003535	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
999541003536	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
999541003537	putative dimerization interface [polypeptide binding]; other site
999541003538	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
999541003539	6-phosphogluconolactonase; Provisional; Region: PRK11028
999541003540	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541003541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541003542	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003543	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003544	trimer interface [polypeptide binding]; other site
999541003545	eyelet of channel; other site
999541003546	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
999541003547	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
999541003548	Sulfate transporter family; Region: Sulfate_transp; pfam00916
999541003549	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
999541003550	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541003551	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541003552	substrate binding pocket [chemical binding]; other site
999541003553	membrane-bound complex binding site; other site
999541003554	hinge residues; other site
999541003555	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
999541003556	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
999541003557	DNA binding residues [nucleotide binding]
999541003558	putative dimer interface [polypeptide binding]; other site
999541003559	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
999541003560	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541003561	Coenzyme A binding pocket [chemical binding]; other site
999541003562	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541003563	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
999541003564	dimer interface [polypeptide binding]; other site
999541003565	ligand binding site [chemical binding]; other site
999541003566	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
999541003567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541003568	dimerization interface [polypeptide binding]; other site
999541003569	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541003570	dimer interface [polypeptide binding]; other site
999541003571	putative CheW interface [polypeptide binding]; other site
999541003572	Nuclease-related domain; Region: NERD; pfam08378
999541003573	AAA domain; Region: AAA_22; pfam13401
999541003574	Part of AAA domain; Region: AAA_19; pfam13245
999541003575	Family description; Region: UvrD_C_2; pfam13538
999541003576	Domain of unknown function (DUF305); Region: DUF305; cl17794
999541003577	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
999541003578	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
999541003579	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
999541003580	BetR domain; Region: BetR; pfam08667
999541003581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541003582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541003583	active site
999541003584	phosphorylation site [posttranslational modification]
999541003585	intermolecular recognition site; other site
999541003586	dimerization interface [polypeptide binding]; other site
999541003587	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541003588	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541003589	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541003590	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
999541003591	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541003592	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541003593	substrate binding pocket [chemical binding]; other site
999541003594	membrane-bound complex binding site; other site
999541003595	hinge residues; other site
999541003596	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541003597	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541003598	substrate binding pocket [chemical binding]; other site
999541003599	membrane-bound complex binding site; other site
999541003600	hinge residues; other site
999541003601	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
999541003602	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541003603	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541003604	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541003605	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541003606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541003607	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
999541003608	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
999541003609	ligand-binding site [chemical binding]; other site
999541003610	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
999541003611	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
999541003612	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541003613	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
999541003614	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
999541003615	active site
999541003616	metal binding site [ion binding]; metal-binding site
999541003617	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
999541003618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003619	putative substrate translocation pore; other site
999541003620	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003622	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541003623	dimerization interface [polypeptide binding]; other site
999541003624	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
999541003625	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541003626	ornithine cyclodeaminase; Validated; Region: PRK07340
999541003627	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
999541003628	OpgC protein; Region: OpgC_C; pfam10129
999541003629	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003630	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003631	trimer interface [polypeptide binding]; other site
999541003632	eyelet of channel; other site
999541003633	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541003634	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541003635	DNA-binding site [nucleotide binding]; DNA binding site
999541003636	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541003637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541003638	homodimer interface [polypeptide binding]; other site
999541003639	catalytic residue [active]
999541003640	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
999541003641	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
999541003642	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
999541003643	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541003644	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541003645	catalytic residue [active]
999541003646	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
999541003647	Predicted amidohydrolase [General function prediction only]; Region: COG0388
999541003648	putative active site [active]
999541003649	catalytic triad [active]
999541003650	putative dimer interface [polypeptide binding]; other site
999541003651	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003652	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003653	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
999541003654	putative dimerization interface [polypeptide binding]; other site
999541003655	Cupin domain; Region: Cupin_2; cl17218
999541003656	Peptidase family M23; Region: Peptidase_M23; pfam01551
999541003657	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
999541003658	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541003659	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003660	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541003661	substrate binding pocket [chemical binding]; other site
999541003662	dimerization interface [polypeptide binding]; other site
999541003663	Fimbrial protein; Region: Fimbrial; cl01416
999541003664	Predicted membrane protein [Function unknown]; Region: COG2261
999541003665	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
999541003666	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541003667	Walker A/P-loop; other site
999541003668	ATP binding site [chemical binding]; other site
999541003669	Q-loop/lid; other site
999541003670	ABC transporter signature motif; other site
999541003671	Walker B; other site
999541003672	D-loop; other site
999541003673	H-loop/switch region; other site
999541003674	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
999541003675	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541003676	Walker A/P-loop; other site
999541003677	ATP binding site [chemical binding]; other site
999541003678	Q-loop/lid; other site
999541003679	ABC transporter signature motif; other site
999541003680	Walker B; other site
999541003681	D-loop; other site
999541003682	H-loop/switch region; other site
999541003683	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
999541003684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003685	dimer interface [polypeptide binding]; other site
999541003686	conserved gate region; other site
999541003687	putative PBP binding loops; other site
999541003688	ABC-ATPase subunit interface; other site
999541003689	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
999541003690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003691	dimer interface [polypeptide binding]; other site
999541003692	conserved gate region; other site
999541003693	putative PBP binding loops; other site
999541003694	ABC-ATPase subunit interface; other site
999541003695	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
999541003696	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
999541003697	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
999541003698	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
999541003699	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
999541003700	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
999541003701	active site
999541003702	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541003703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541003704	Walker A motif; other site
999541003705	ATP binding site [chemical binding]; other site
999541003706	Walker B motif; other site
999541003707	arginine finger; other site
999541003708	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
999541003709	phage tail protein domain; Region: tail_TIGR02242
999541003710	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
999541003711	Baseplate J-like protein; Region: Baseplate_J; cl01294
999541003712	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
999541003713	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
999541003714	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
999541003715	PAAR motif; Region: PAAR_motif; pfam05488
999541003716	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541003717	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541003718	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
999541003719	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
999541003720	tail sheath protein; Provisional; Region: 18; PHA02539
999541003721	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
999541003722	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
999541003723	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
999541003724	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
999541003725	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
999541003726	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
999541003727	putative molybdopterin cofactor binding site [chemical binding]; other site
999541003728	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
999541003729	putative molybdopterin cofactor binding site; other site
999541003730	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541003731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541003732	DNA-binding site [nucleotide binding]; DNA binding site
999541003733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541003734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541003735	homodimer interface [polypeptide binding]; other site
999541003736	catalytic residue [active]
999541003737	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
999541003738	putative dimer interface [polypeptide binding]; other site
999541003739	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541003740	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
999541003741	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
999541003742	C-terminal domain interface [polypeptide binding]; other site
999541003743	GSH binding site (G-site) [chemical binding]; other site
999541003744	dimer interface [polypeptide binding]; other site
999541003745	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541003746	N-terminal domain interface [polypeptide binding]; other site
999541003747	dimer interface [polypeptide binding]; other site
999541003748	substrate binding pocket (H-site) [chemical binding]; other site
999541003749	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541003750	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
999541003751	putative C-terminal domain interface [polypeptide binding]; other site
999541003752	putative GSH binding site (G-site) [chemical binding]; other site
999541003753	putative dimer interface [polypeptide binding]; other site
999541003754	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
999541003755	putative N-terminal domain interface [polypeptide binding]; other site
999541003756	putative dimer interface [polypeptide binding]; other site
999541003757	putative substrate binding pocket (H-site) [chemical binding]; other site
999541003758	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
999541003759	Isochorismatase family; Region: Isochorismatase; pfam00857
999541003760	catalytic triad [active]
999541003761	conserved cis-peptide bond; other site
999541003762	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
999541003763	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
999541003764	putative FMN binding site [chemical binding]; other site
999541003765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541003766	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541003767	active site
999541003768	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
999541003769	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003770	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
999541003771	putative dimerization interface [polypeptide binding]; other site
999541003772	putative substrate binding pocket [chemical binding]; other site
999541003773	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541003774	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541003775	trimer interface [polypeptide binding]; other site
999541003776	eyelet of channel; other site
999541003777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003778	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541003779	putative substrate translocation pore; other site
999541003780	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
999541003781	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
999541003782	Autotransporter beta-domain; Region: Autotransporter; pfam03797
999541003783	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541003784	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
999541003785	magnesium-transporting ATPase; Provisional; Region: PRK15122
999541003786	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
999541003787	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
999541003788	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
999541003789	Soluble P-type ATPase [General function prediction only]; Region: COG4087
999541003790	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
999541003791	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
999541003792	active site
999541003793	catalytic triad [active]
999541003794	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
999541003795	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
999541003796	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
999541003797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003798	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
999541003799	substrate binding pocket [chemical binding]; other site
999541003800	dimerization interface [polypeptide binding]; other site
999541003801	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
999541003802	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
999541003803	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
999541003804	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
999541003805	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
999541003806	DctM-like transporters; Region: DctM; pfam06808
999541003807	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
999541003808	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
999541003809	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541003810	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541003811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541003812	putative DNA binding site [nucleotide binding]; other site
999541003813	putative Zn2+ binding site [ion binding]; other site
999541003814	AsnC family; Region: AsnC_trans_reg; pfam01037
999541003815	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
999541003816	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
999541003817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541003818	catalytic residue [active]
999541003819	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
999541003820	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
999541003821	NADP binding site [chemical binding]; other site
999541003822	homodimer interface [polypeptide binding]; other site
999541003823	active site
999541003824	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
999541003825	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
999541003826	putative NAD(P) binding site [chemical binding]; other site
999541003827	catalytic Zn binding site [ion binding]; other site
999541003828	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541003829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541003830	dimer interface [polypeptide binding]; other site
999541003831	conserved gate region; other site
999541003832	putative PBP binding loops; other site
999541003833	ABC-ATPase subunit interface; other site
999541003834	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
999541003835	NMT1-like family; Region: NMT1_2; pfam13379
999541003836	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541003837	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541003838	Walker A/P-loop; other site
999541003839	ATP binding site [chemical binding]; other site
999541003840	Q-loop/lid; other site
999541003841	ABC transporter signature motif; other site
999541003842	Walker B; other site
999541003843	D-loop; other site
999541003844	H-loop/switch region; other site
999541003845	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541003846	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541003847	Uncharacterized conserved protein [Function unknown]; Region: COG2128
999541003848	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
999541003849	Cupin; Region: Cupin_6; pfam12852
999541003850	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541003851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541003852	MAPEG family; Region: MAPEG; cl09190
999541003853	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003855	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541003856	putative effector binding pocket; other site
999541003857	putative dimerization interface [polypeptide binding]; other site
999541003858	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
999541003859	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
999541003860	catalytic residue [active]
999541003861	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
999541003862	catalytic residues [active]
999541003863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541003864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541003865	peroxiredoxin; Region: AhpC; TIGR03137
999541003866	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
999541003867	dimer interface [polypeptide binding]; other site
999541003868	decamer (pentamer of dimers) interface [polypeptide binding]; other site
999541003869	catalytic triad [active]
999541003870	peroxidatic and resolving cysteines [active]
999541003871	Protein of unknown function (DUF817); Region: DUF817; pfam05675
999541003872	hypothetical protein; Provisional; Region: PRK10396
999541003873	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
999541003874	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
999541003875	dimer interface [polypeptide binding]; other site
999541003876	FMN binding site [chemical binding]; other site
999541003877	NADPH bind site [chemical binding]; other site
999541003878	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
999541003879	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
999541003880	putative FMN binding site [chemical binding]; other site
999541003881	Uncharacterized conserved protein [Function unknown]; Region: COG2308
999541003882	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
999541003883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
999541003884	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
999541003885	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
999541003886	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
999541003887	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
999541003888	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
999541003889	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
999541003890	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
999541003891	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
999541003892	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
999541003893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
999541003894	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
999541003895	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
999541003896	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
999541003897	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
999541003898	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541003899	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541003900	metal binding site [ion binding]; metal-binding site
999541003901	active site
999541003902	I-site; other site
999541003903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003904	putative substrate translocation pore; other site
999541003905	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541003906	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003908	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
999541003909	putative effector binding pocket; other site
999541003910	putative dimerization interface [polypeptide binding]; other site
999541003911	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
999541003912	intracellular protease, PfpI family; Region: PfpI; TIGR01382
999541003913	proposed catalytic triad [active]
999541003914	conserved cys residue [active]
999541003915	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541003916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541003917	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003918	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541003919	dimerization interface [polypeptide binding]; other site
999541003920	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541003921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541003922	DNA-binding site [nucleotide binding]; DNA binding site
999541003923	FCD domain; Region: FCD; pfam07729
999541003924	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
999541003925	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
999541003926	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
999541003927	TAP-like protein; Region: Abhydrolase_4; pfam08386
999541003928	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
999541003929	Uncharacterized conserved protein [Function unknown]; Region: COG5649
999541003930	Predicted membrane protein [Function unknown]; Region: COG1289
999541003931	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541003932	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541003933	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
999541003934	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541003935	catalytic residue [active]
999541003936	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541003937	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
999541003938	PYR/PP interface [polypeptide binding]; other site
999541003939	dimer interface [polypeptide binding]; other site
999541003940	TPP binding site [chemical binding]; other site
999541003941	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
999541003942	TPP-binding site [chemical binding]; other site
999541003943	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
999541003944	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
999541003945	tetramer interface [polypeptide binding]; other site
999541003946	active site
999541003947	Mg2+/Mn2+ binding site [ion binding]; other site
999541003948	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
999541003949	active site
999541003950	metal-binding site
999541003951	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
999541003952	active site
999541003953	metal-binding site
999541003954	putative membrane protein; Region: HpnL; TIGR03476
999541003955	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
999541003956	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
999541003957	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
999541003958	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541003959	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541003960	dimerization interface [polypeptide binding]; other site
999541003961	ligand binding site [chemical binding]; other site
999541003962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541003963	S-adenosylmethionine binding site [chemical binding]; other site
999541003964	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
999541003965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541003966	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
999541003967	putative dimerization interface [polypeptide binding]; other site
999541003968	dihydroxy-acid dehydratase; Validated; Region: PRK06131
999541003969	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541003970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541003971	putative substrate translocation pore; other site
999541003972	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541003973	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541003974	inhibitor site; inhibition site
999541003975	active site
999541003976	dimer interface [polypeptide binding]; other site
999541003977	catalytic residue [active]
999541003978	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
999541003979	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541003980	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
999541003981	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
999541003982	ligand binding site [chemical binding]; other site
999541003983	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
999541003984	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541003985	Walker A/P-loop; other site
999541003986	ATP binding site [chemical binding]; other site
999541003987	Q-loop/lid; other site
999541003988	ABC transporter signature motif; other site
999541003989	Walker B; other site
999541003990	D-loop; other site
999541003991	H-loop/switch region; other site
999541003992	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541003993	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541003994	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541003995	TM-ABC transporter signature motif; other site
999541003996	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541003997	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541003998	DNA-binding site [nucleotide binding]; DNA binding site
999541003999	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541004000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541004001	homodimer interface [polypeptide binding]; other site
999541004002	catalytic residue [active]
999541004003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541004004	Zn2+ binding site [ion binding]; other site
999541004005	Mg2+ binding site [ion binding]; other site
999541004006	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
999541004007	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
999541004008	homodimer interface [polypeptide binding]; other site
999541004009	substrate-cofactor binding pocket; other site
999541004010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541004011	catalytic residue [active]
999541004012	aldolase II superfamily protein; Provisional; Region: PRK07044
999541004013	intersubunit interface [polypeptide binding]; other site
999541004014	active site
999541004015	Zn2+ binding site [ion binding]; other site
999541004016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004018	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541004019	dimerization interface [polypeptide binding]; other site
999541004020	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
999541004021	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541004022	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004023	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004024	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541004025	dimerization interface [polypeptide binding]; other site
999541004026	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
999541004027	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541004028	inhibitor-cofactor binding pocket; inhibition site
999541004029	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541004030	catalytic residue [active]
999541004031	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541004032	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541004033	active site
999541004034	non-prolyl cis peptide bond; other site
999541004035	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
999541004036	Fusaric acid resistance protein family; Region: FUSC; pfam04632
999541004037	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541004038	transcriptional regulator; Provisional; Region: PRK10632
999541004039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004040	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541004041	putative effector binding pocket; other site
999541004042	dimerization interface [polypeptide binding]; other site
999541004043	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541004044	cytosine deaminase; Provisional; Region: PRK09230
999541004045	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
999541004046	active site
999541004047	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
999541004048	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541004049	catalytic loop [active]
999541004050	iron binding site [ion binding]; other site
999541004051	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
999541004052	FAD binding pocket [chemical binding]; other site
999541004053	conserved FAD binding motif [chemical binding]; other site
999541004054	phosphate binding motif [ion binding]; other site
999541004055	beta-alpha-beta structure motif; other site
999541004056	NAD binding pocket [chemical binding]; other site
999541004057	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
999541004058	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541004059	catalytic loop [active]
999541004060	iron binding site [ion binding]; other site
999541004061	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
999541004062	active site
999541004063	amidase; Provisional; Region: PRK07056
999541004064	Amidase; Region: Amidase; cl11426
999541004065	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
999541004066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004067	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541004068	putative substrate translocation pore; other site
999541004069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004071	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541004072	dimerization interface [polypeptide binding]; other site
999541004073	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541004074	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541004075	eyelet of channel; other site
999541004076	trimer interface [polypeptide binding]; other site
999541004077	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541004078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004079	putative substrate translocation pore; other site
999541004080	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
999541004081	short chain dehydrogenase; Provisional; Region: PRK12829
999541004082	classical (c) SDRs; Region: SDR_c; cd05233
999541004083	NAD(P) binding site [chemical binding]; other site
999541004084	active site
999541004085	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541004086	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
999541004087	FCD domain; Region: FCD; pfam07729
999541004088	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
999541004089	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
999541004090	putative ion selectivity filter; other site
999541004091	putative pore gating glutamate residue; other site
999541004092	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
999541004093	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
999541004094	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
999541004095	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
999541004096	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
999541004097	Trp docking motif [polypeptide binding]; other site
999541004098	putative active site [active]
999541004099	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541004100	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541004101	trimer interface [polypeptide binding]; other site
999541004102	eyelet of channel; other site
999541004103	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541004104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004105	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541004106	dimerization interface [polypeptide binding]; other site
999541004107	substrate binding pocket [chemical binding]; other site
999541004108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004109	putative substrate translocation pore; other site
999541004110	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541004111	short chain dehydrogenase; Provisional; Region: PRK06123
999541004112	classical (c) SDRs; Region: SDR_c; cd05233
999541004113	NAD(P) binding site [chemical binding]; other site
999541004114	active site
999541004115	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
999541004116	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
999541004117	Peptidase family M50; Region: Peptidase_M50; pfam02163
999541004118	active site
999541004119	putative substrate binding region [chemical binding]; other site
999541004120	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004121	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541004122	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004123	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541004124	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004125	Outer membrane efflux protein; Region: OEP; pfam02321
999541004126	Outer membrane efflux protein; Region: OEP; pfam02321
999541004127	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
999541004128	Cadherin repeat-like domain; Region: CA_like; cl15786
999541004129	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
999541004130	Phage Tail Collar Domain; Region: Collar; pfam07484
999541004131	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541004132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541004133	Coenzyme A binding pocket [chemical binding]; other site
999541004134	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
999541004135	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
999541004136	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541004137	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541004138	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
999541004139	AsnC family; Region: AsnC_trans_reg; pfam01037
999541004140	aromatic amino acid transporter; Provisional; Region: PRK10238
999541004141	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
999541004142	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541004143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541004144	homodimer interface [polypeptide binding]; other site
999541004145	catalytic residue [active]
999541004146	Protein of unknown function, DUF488; Region: DUF488; cl01246
999541004147	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
999541004148	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541004149	motif II; other site
999541004150	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
999541004151	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541004152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541004153	active site
999541004154	phosphorylation site [posttranslational modification]
999541004155	intermolecular recognition site; other site
999541004156	dimerization interface [polypeptide binding]; other site
999541004157	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541004158	DNA binding residues [nucleotide binding]
999541004159	dimerization interface [polypeptide binding]; other site
999541004160	PAS domain S-box; Region: sensory_box; TIGR00229
999541004161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541004162	putative active site [active]
999541004163	heme pocket [chemical binding]; other site
999541004164	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
999541004165	Histidine kinase; Region: HisKA_3; pfam07730
999541004166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541004167	ATP binding site [chemical binding]; other site
999541004168	Mg2+ binding site [ion binding]; other site
999541004169	G-X-G motif; other site
999541004170	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
999541004171	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
999541004172	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
999541004173	active site residue [active]
999541004174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541004175	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541004176	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541004177	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541004178	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541004179	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
999541004180	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
999541004181	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541004182	Sel1-like repeats; Region: SEL1; smart00671
999541004183	pyruvate dehydrogenase; Provisional; Region: PRK09124
999541004184	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
999541004185	PYR/PP interface [polypeptide binding]; other site
999541004186	tetramer interface [polypeptide binding]; other site
999541004187	dimer interface [polypeptide binding]; other site
999541004188	TPP binding site [chemical binding]; other site
999541004189	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541004190	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
999541004191	TPP-binding site [chemical binding]; other site
999541004192	ProQ/FINO family; Region: ProQ; pfam04352
999541004193	Cache domain; Region: Cache_1; pfam02743
999541004194	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541004195	dimerization interface [polypeptide binding]; other site
999541004196	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541004197	dimer interface [polypeptide binding]; other site
999541004198	putative CheW interface [polypeptide binding]; other site
999541004199	H-NS histone family; Region: Histone_HNS; pfam00816
999541004200	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541004201	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
999541004202	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541004203	NAD(P) binding site [chemical binding]; other site
999541004204	catalytic residues [active]
999541004205	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541004206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541004207	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
999541004208	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
999541004209	Transglycosylase; Region: Transgly; pfam00912
999541004210	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541004211	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
999541004212	Bacterial Ig-like domain; Region: Big_5; pfam13205
999541004213	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
999541004214	MG2 domain; Region: A2M_N; pfam01835
999541004215	Alpha-2-macroglobulin family; Region: A2M; pfam00207
999541004216	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
999541004217	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541004218	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541004219	eyelet of channel; other site
999541004220	trimer interface [polypeptide binding]; other site
999541004221	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
999541004222	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
999541004223	putative active site [active]
999541004224	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541004225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004226	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541004227	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541004228	metal binding site [ion binding]; metal-binding site
999541004229	putative dimer interface [polypeptide binding]; other site
999541004230	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
999541004231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541004233	dimerization interface [polypeptide binding]; other site
999541004234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
999541004235	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541004236	MarR family; Region: MarR_2; pfam12802
999541004237	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
999541004238	HPP family; Region: HPP; pfam04982
999541004239	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
999541004240	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004242	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541004243	putative effector binding pocket; other site
999541004244	dimerization interface [polypeptide binding]; other site
999541004245	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
999541004246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
999541004247	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
999541004248	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
999541004249	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541004250	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
999541004251	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541004252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541004253	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541004254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541004255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004256	putative substrate translocation pore; other site
999541004257	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
999541004258	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
999541004259	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541004260	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004261	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
999541004262	Fusaric acid resistance protein family; Region: FUSC; pfam04632
999541004263	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541004264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541004265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
999541004266	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
999541004267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
999541004268	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
999541004269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
999541004270	LabA_like proteins; Region: LabA_like; cd06167
999541004271	putative metal binding site [ion binding]; other site
999541004272	Uncharacterized conserved protein [Function unknown]; Region: COG1432
999541004273	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
999541004274	Beta-lactamase; Region: Beta-lactamase; pfam00144
999541004275	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
999541004276	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
999541004277	heterodimer interface [polypeptide binding]; other site
999541004278	active site
999541004279	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
999541004280	heterodimer interface [polypeptide binding]; other site
999541004281	multimer interface [polypeptide binding]; other site
999541004282	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
999541004283	active site
999541004284	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
999541004285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004286	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541004287	dimerization interface [polypeptide binding]; other site
999541004288	Cache domain; Region: Cache_1; pfam02743
999541004289	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541004290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541004291	metal binding site [ion binding]; metal-binding site
999541004292	active site
999541004293	I-site; other site
999541004294	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541004295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541004296	Walker A motif; other site
999541004297	ATP binding site [chemical binding]; other site
999541004298	Walker B motif; other site
999541004299	arginine finger; other site
999541004300	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
999541004301	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
999541004302	putative active site [active]
999541004303	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
999541004304	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
999541004305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541004306	dimer interface [polypeptide binding]; other site
999541004307	phosphorylation site [posttranslational modification]
999541004308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541004309	ATP binding site [chemical binding]; other site
999541004310	Mg2+ binding site [ion binding]; other site
999541004311	G-X-G motif; other site
999541004312	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
999541004313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541004314	active site
999541004315	phosphorylation site [posttranslational modification]
999541004316	intermolecular recognition site; other site
999541004317	dimerization interface [polypeptide binding]; other site
999541004318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541004319	DNA binding site [nucleotide binding]
999541004320	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541004321	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541004322	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004323	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541004324	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541004325	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541004326	ligand binding site [chemical binding]; other site
999541004327	flexible hinge region; other site
999541004328	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
999541004329	acyl-CoA synthetase; Validated; Region: PRK08162
999541004330	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
999541004331	acyl-activating enzyme (AAE) consensus motif; other site
999541004332	putative active site [active]
999541004333	AMP binding site [chemical binding]; other site
999541004334	putative CoA binding site [chemical binding]; other site
999541004335	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
999541004336	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
999541004337	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
999541004338	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
999541004339	Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970
999541004340	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
999541004341	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
999541004342	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541004343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541004344	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
999541004345	active site
999541004346	SAM binding site [chemical binding]; other site
999541004347	homodimer interface [polypeptide binding]; other site
999541004348	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541004349	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541004350	eyelet of channel; other site
999541004351	trimer interface [polypeptide binding]; other site
999541004352	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
999541004353	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541004354	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
999541004355	DEAD_2; Region: DEAD_2; pfam06733
999541004356	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
999541004357	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
999541004358	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
999541004359	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
999541004360	Flavin binding site [chemical binding]; other site
999541004361	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541004362	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541004363	DNA-binding site [nucleotide binding]; DNA binding site
999541004364	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541004365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541004366	homodimer interface [polypeptide binding]; other site
999541004367	catalytic residue [active]
999541004368	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541004369	Methyltransferase domain; Region: Methyltransf_18; pfam12847
999541004370	S-adenosylmethionine binding site [chemical binding]; other site
999541004371	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541004372	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541004373	active site
999541004374	catalytic tetrad [active]
999541004375	Uncharacterized conserved protein [Function unknown]; Region: COG3868
999541004376	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
999541004377	putative active site [active]
999541004378	Tetratricopeptide repeat; Region: TPR_15; pfam13429
999541004379	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
999541004380	GAF domain; Region: GAF_3; pfam13492
999541004381	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
999541004382	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541004383	Predicted membrane protein [Function unknown]; Region: COG4267
999541004384	Killing trait; Region: RebB; pfam11747
999541004385	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
999541004386	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541004387	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541004388	shikimate transporter; Provisional; Region: PRK09952
999541004389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004390	putative substrate translocation pore; other site
999541004391	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
999541004392	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
999541004393	dimer interface [polypeptide binding]; other site
999541004394	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
999541004395	active site
999541004396	Fe binding site [ion binding]; other site
999541004397	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
999541004398	classical (c) SDRs; Region: SDR_c; cd05233
999541004399	NAD(P) binding site [chemical binding]; other site
999541004400	active site
999541004401	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541004402	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
999541004403	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541004404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004405	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541004406	dimerization interface [polypeptide binding]; other site
999541004407	substrate binding pocket [chemical binding]; other site
999541004408	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
999541004409	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
999541004410	active site
999541004411	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
999541004412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541004415	dimerization interface [polypeptide binding]; other site
999541004416	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
999541004417	active site
999541004418	tetramer interface [polypeptide binding]; other site
999541004419	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541004420	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541004421	eyelet of channel; other site
999541004422	trimer interface [polypeptide binding]; other site
999541004423	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541004424	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
999541004425	NAD(P) binding site [chemical binding]; other site
999541004426	catalytic residues [active]
999541004427	benzoate transport; Region: 2A0115; TIGR00895
999541004428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004429	putative substrate translocation pore; other site
999541004430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004431	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
999541004432	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541004433	substrate binding site [chemical binding]; other site
999541004434	trimer interface [polypeptide binding]; other site
999541004435	oxyanion hole (OAH) forming residues; other site
999541004436	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
999541004437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541004438	DNA-binding site [nucleotide binding]; DNA binding site
999541004439	FCD domain; Region: FCD; pfam07729
999541004440	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
999541004441	haemagglutination activity domain; Region: Haemagg_act; cl05436
999541004442	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541004443	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541004444	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541004445	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
999541004446	aromatic chitin/cellulose binding site residues [chemical binding]; other site
999541004447	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
999541004448	putative sugar binding site [chemical binding]; other site
999541004449	catalytic residues [active]
999541004450	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
999541004451	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541004452	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541004453	dimer interface [polypeptide binding]; other site
999541004454	putative CheW interface [polypeptide binding]; other site
999541004455	Predicted membrane protein [Function unknown]; Region: COG2259
999541004456	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541004457	short chain dehydrogenase; Provisional; Region: PRK12937
999541004458	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
999541004459	NADP binding site [chemical binding]; other site
999541004460	homodimer interface [polypeptide binding]; other site
999541004461	active site
999541004462	substrate binding site [chemical binding]; other site
999541004463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004465	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541004466	putative effector binding pocket; other site
999541004467	putative dimerization interface [polypeptide binding]; other site
999541004468	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
999541004469	Sulfatase; Region: Sulfatase; cl17466
999541004470	Sulfatase; Region: Sulfatase; cl17466
999541004471	Sulfatase; Region: Sulfatase; cl17466
999541004472	Uncharacterized conserved protein [Function unknown]; Region: COG1262
999541004473	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
999541004474	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
999541004475	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
999541004476	Predicted transcriptional regulator [Transcription]; Region: COG1959
999541004477	Transcriptional regulator; Region: Rrf2; pfam02082
999541004478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
999541004479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541004480	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541004481	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
999541004482	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
999541004483	NMT1-like family; Region: NMT1_2; pfam13379
999541004484	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541004485	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541004486	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541004487	Walker A/P-loop; other site
999541004488	ATP binding site [chemical binding]; other site
999541004489	Q-loop/lid; other site
999541004490	ABC transporter signature motif; other site
999541004491	Walker B; other site
999541004492	D-loop; other site
999541004493	H-loop/switch region; other site
999541004494	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541004495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541004496	putative PBP binding loops; other site
999541004497	dimer interface [polypeptide binding]; other site
999541004498	ABC-ATPase subunit interface; other site
999541004499	lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317
999541004500	active site
999541004501	homopentamer interface [polypeptide binding]; other site
999541004502	putative proline-specific permease; Provisional; Region: proY; PRK10580
999541004503	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
999541004504	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
999541004505	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
999541004506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541004507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541004508	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
999541004509	isovaleryl-CoA dehydrogenase; Region: PLN02519
999541004510	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
999541004511	substrate binding site [chemical binding]; other site
999541004512	FAD binding site [chemical binding]; other site
999541004513	catalytic base [active]
999541004514	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
999541004515	enoyl-CoA hydratase; Provisional; Region: PRK05995
999541004516	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541004517	substrate binding site [chemical binding]; other site
999541004518	oxyanion hole (OAH) forming residues; other site
999541004519	trimer interface [polypeptide binding]; other site
999541004520	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
999541004521	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541004522	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541004523	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
999541004524	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
999541004525	carboxyltransferase (CT) interaction site; other site
999541004526	biotinylation site [posttranslational modification]; other site
999541004527	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541004528	Epoxide hydrolase N terminus; Region: EHN; pfam06441
999541004529	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541004530	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541004531	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541004532	N-terminal plug; other site
999541004533	ligand-binding site [chemical binding]; other site
999541004534	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
999541004535	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
999541004536	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
999541004537	active site
999541004538	ATP binding site [chemical binding]; other site
999541004539	substrate binding site [chemical binding]; other site
999541004540	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004542	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541004543	dimerization interface [polypeptide binding]; other site
999541004544	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
999541004545	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541004546	putative NAD(P) binding site [chemical binding]; other site
999541004547	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
999541004548	hypothetical protein; Provisional; Region: PRK05409
999541004549	Ferritin-like; Region: Ferritin-like; pfam12902
999541004550	glycosyl hydrolase 64 family; Region: GH64-like; cd09214
999541004551	substrate binding pocket [chemical binding]; other site
999541004552	catalytic residues [active]
999541004553	Predicted methyltransferase [General function prediction only]; Region: COG4798
999541004554	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541004555	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541004556	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
999541004557	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541004558	putative ligand binding site [chemical binding]; other site
999541004559	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541004560	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541004561	Walker A/P-loop; other site
999541004562	ATP binding site [chemical binding]; other site
999541004563	Q-loop/lid; other site
999541004564	ABC transporter signature motif; other site
999541004565	Walker B; other site
999541004566	D-loop; other site
999541004567	H-loop/switch region; other site
999541004568	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541004569	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541004570	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541004571	TM-ABC transporter signature motif; other site
999541004572	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541004573	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541004574	TM-ABC transporter signature motif; other site
999541004575	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541004576	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
999541004577	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
999541004578	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
999541004579	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
999541004580	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
999541004581	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
999541004582	nucleotide binding site [chemical binding]; other site
999541004583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541004584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541004585	Helix-turn-helix domain; Region: HTH_28; pfam13518
999541004586	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541004587	putative transposase OrfB; Reviewed; Region: PHA02517
999541004588	HTH-like domain; Region: HTH_21; pfam13276
999541004589	Integrase core domain; Region: rve; pfam00665
999541004590	Integrase core domain; Region: rve_2; pfam13333
999541004591	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428
999541004592	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
999541004593	active site
999541004594	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541004595	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541004596	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541004597	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004598	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541004599	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
999541004600	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
999541004601	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
999541004602	dimer interface [polypeptide binding]; other site
999541004603	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541004604	metal binding site [ion binding]; metal-binding site
999541004605	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
999541004606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541004607	DNA-binding site [nucleotide binding]; DNA binding site
999541004608	UTRA domain; Region: UTRA; pfam07702
999541004609	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
999541004610	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
999541004611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004612	D-galactonate transporter; Region: 2A0114; TIGR00893
999541004613	putative substrate translocation pore; other site
999541004614	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541004615	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
999541004616	active site
999541004617	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541004618	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
999541004619	NAD(P) binding site [chemical binding]; other site
999541004620	Cupin; Region: Cupin_6; pfam12852
999541004621	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541004622	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541004623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541004624	Cupin; Region: Cupin_6; pfam12852
999541004625	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541004626	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541004627	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
999541004628	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541004629	NADP binding site [chemical binding]; other site
999541004630	active site
999541004631	steroid binding site; other site
999541004632	oxidoreductase; Provisional; Region: PRK06196
999541004633	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
999541004634	putative NAD(P) binding site [chemical binding]; other site
999541004635	active site
999541004636	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004638	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541004639	dimerization interface [polypeptide binding]; other site
999541004640	substrate binding pocket [chemical binding]; other site
999541004641	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541004642	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541004643	NAD(P) binding site [chemical binding]; other site
999541004644	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541004645	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541004646	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
999541004647	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
999541004648	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541004649	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
999541004650	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
999541004651	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541004652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541004653	dimer interface [polypeptide binding]; other site
999541004654	conserved gate region; other site
999541004655	putative PBP binding loops; other site
999541004656	ABC-ATPase subunit interface; other site
999541004657	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541004658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541004659	dimer interface [polypeptide binding]; other site
999541004660	conserved gate region; other site
999541004661	putative PBP binding loops; other site
999541004662	ABC-ATPase subunit interface; other site
999541004663	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541004664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541004665	Walker A/P-loop; other site
999541004666	ATP binding site [chemical binding]; other site
999541004667	Q-loop/lid; other site
999541004668	ABC transporter signature motif; other site
999541004669	Walker B; other site
999541004670	D-loop; other site
999541004671	H-loop/switch region; other site
999541004672	TOBE domain; Region: TOBE_2; pfam08402
999541004673	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541004674	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541004675	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541004676	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541004677	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
999541004678	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
999541004679	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541004680	motif II; other site
999541004681	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004683	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541004684	dimerization interface [polypeptide binding]; other site
999541004685	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
999541004686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541004687	motif II; other site
999541004688	hypothetical protein; Provisional; Region: PRK06486
999541004689	intersubunit interface [polypeptide binding]; other site
999541004690	active site
999541004691	Zn2+ binding site [ion binding]; other site
999541004692	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541004693	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541004694	active site
999541004695	catalytic tetrad [active]
999541004696	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541004697	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541004698	metal binding site [ion binding]; metal-binding site
999541004699	active site
999541004700	I-site; other site
999541004701	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
999541004702	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541004703	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541004704	DNA binding site [nucleotide binding]
999541004705	domain linker motif; other site
999541004706	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
999541004707	ligand binding site [chemical binding]; other site
999541004708	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541004709	dimerization interface [polypeptide binding]; other site
999541004710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541004711	ATP binding site [chemical binding]; other site
999541004712	Mg2+ binding site [ion binding]; other site
999541004713	G-X-G motif; other site
999541004714	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541004715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541004716	active site
999541004717	phosphorylation site [posttranslational modification]
999541004718	intermolecular recognition site; other site
999541004719	dimerization interface [polypeptide binding]; other site
999541004720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541004721	DNA binding site [nucleotide binding]
999541004722	Uncharacterized conserved protein [Function unknown]; Region: COG3791
999541004723	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
999541004724	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541004725	catalytic residues [active]
999541004726	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
999541004727	DHHW protein; Region: DHHW; pfam14286
999541004728	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
999541004729	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
999541004730	ring oligomerisation interface [polypeptide binding]; other site
999541004731	ATP/Mg binding site [chemical binding]; other site
999541004732	stacking interactions; other site
999541004733	hinge regions; other site
999541004734	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
999541004735	oligomerisation interface [polypeptide binding]; other site
999541004736	mobile loop; other site
999541004737	roof hairpin; other site
999541004738	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
999541004739	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004740	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
999541004741	putative dimerization interface [polypeptide binding]; other site
999541004742	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541004743	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
999541004744	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
999541004745	methionine synthase; Provisional; Region: PRK01207
999541004746	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
999541004747	substrate binding site [chemical binding]; other site
999541004748	THF binding site; other site
999541004749	zinc-binding site [ion binding]; other site
999541004750	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541004751	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541004752	active site
999541004753	catalytic tetrad [active]
999541004754	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541004755	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
999541004756	metal ion-dependent adhesion site (MIDAS); other site
999541004757	Protein phosphatase 2C; Region: PP2C_2; pfam13672
999541004758	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
999541004759	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
999541004760	substrate binding site [chemical binding]; other site
999541004761	activation loop (A-loop); other site
999541004762	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
999541004763	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
999541004764	Protein of unknown function, DUF393; Region: DUF393; pfam04134
999541004765	Domain of unknown function (DUF1731); Region: DUF1731; pfam08338
999541004766	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
999541004767	Moco binding site; other site
999541004768	metal coordination site [ion binding]; other site
999541004769	dimerization interface [polypeptide binding]; other site
999541004770	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541004771	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
999541004772	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
999541004773	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
999541004774	active site
999541004775	ATP binding site [chemical binding]; other site
999541004776	substrate binding site [chemical binding]; other site
999541004777	activation loop (A-loop); other site
999541004778	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
999541004779	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
999541004780	TPP-binding site [chemical binding]; other site
999541004781	dimer interface [polypeptide binding]; other site
999541004782	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
999541004783	PYR/PP interface [polypeptide binding]; other site
999541004784	dimer interface [polypeptide binding]; other site
999541004785	TPP binding site [chemical binding]; other site
999541004786	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
999541004787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541004788	dimer interface [polypeptide binding]; other site
999541004789	conserved gate region; other site
999541004790	putative PBP binding loops; other site
999541004791	ABC-ATPase subunit interface; other site
999541004792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541004793	dimer interface [polypeptide binding]; other site
999541004794	conserved gate region; other site
999541004795	putative PBP binding loops; other site
999541004796	ABC-ATPase subunit interface; other site
999541004797	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541004798	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541004799	substrate binding pocket [chemical binding]; other site
999541004800	membrane-bound complex binding site; other site
999541004801	hinge residues; other site
999541004802	multidrug resistance protein MdtN; Provisional; Region: PRK10476
999541004803	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541004804	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541004805	Fusaric acid resistance protein family; Region: FUSC; pfam04632
999541004806	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541004807	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
999541004808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004809	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541004810	Cupin-like domain; Region: Cupin_8; pfam13621
999541004811	Condensation domain; Region: Condensation; pfam00668
999541004812	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541004813	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541004814	acyl-activating enzyme (AAE) consensus motif; other site
999541004815	AMP binding site [chemical binding]; other site
999541004816	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004817	Condensation domain; Region: Condensation; pfam00668
999541004818	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541004819	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541004820	acyl-activating enzyme (AAE) consensus motif; other site
999541004821	AMP binding site [chemical binding]; other site
999541004822	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004823	Condensation domain; Region: Condensation; pfam00668
999541004824	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541004825	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541004826	acyl-activating enzyme (AAE) consensus motif; other site
999541004827	AMP binding site [chemical binding]; other site
999541004828	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004829	Condensation domain; Region: Condensation; pfam00668
999541004830	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
999541004831	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541004832	acyl-activating enzyme (AAE) consensus motif; other site
999541004833	AMP binding site [chemical binding]; other site
999541004834	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004835	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
999541004836	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541004837	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541004838	acyl-activating enzyme (AAE) consensus motif; other site
999541004839	AMP binding site [chemical binding]; other site
999541004840	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004841	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
999541004842	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
999541004843	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
999541004844	chorismate binding enzyme; Region: Chorismate_bind; cl10555
999541004845	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541004846	active site
999541004847	metal binding site [ion binding]; metal-binding site
999541004848	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541004849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541004851	dimerization interface [polypeptide binding]; other site
999541004852	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541004853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004854	putative substrate translocation pore; other site
999541004855	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
999541004856	intersubunit interface [polypeptide binding]; other site
999541004857	active site
999541004858	Zn2+ binding site [ion binding]; other site
999541004859	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541004860	multiple promoter invertase; Provisional; Region: mpi; PRK13413
999541004861	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
999541004862	catalytic residues [active]
999541004863	catalytic nucleophile [active]
999541004864	Presynaptic Site I dimer interface [polypeptide binding]; other site
999541004865	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
999541004866	Synaptic Flat tetramer interface [polypeptide binding]; other site
999541004867	Synaptic Site I dimer interface [polypeptide binding]; other site
999541004868	DNA binding site [nucleotide binding]
999541004869	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
999541004870	DNA-binding interface [nucleotide binding]; DNA binding site
999541004871	H-NS histone family; Region: Histone_HNS; pfam00816
999541004872	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541004873	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541004874	Protein of unknown function (DUF2827); Region: DUF2827; pfam10933
999541004875	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541004876	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541004877	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541004878	ligand binding site [chemical binding]; other site
999541004879	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
999541004880	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541004881	trimer interface [polypeptide binding]; other site
999541004882	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541004883	trimer interface [polypeptide binding]; other site
999541004884	YadA-like C-terminal region; Region: YadA; pfam03895
999541004885	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541004886	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541004887	active site
999541004888	non-prolyl cis peptide bond; other site
999541004889	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
999541004890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541004891	DNA-binding site [nucleotide binding]; DNA binding site
999541004892	UTRA domain; Region: UTRA; pfam07702
999541004893	putative oxidoreductase; Provisional; Region: PRK08275
999541004894	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
999541004895	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
999541004896	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
999541004897	HEAT repeats; Region: HEAT_2; pfam13646
999541004898	HEAT repeats; Region: HEAT_2; pfam13646
999541004899	Protein of unknown function (DUF971); Region: DUF971; pfam06155
999541004900	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
999541004901	Beta-lactamase; Region: Beta-lactamase; pfam00144
999541004902	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541004903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541004904	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541004905	putative effector binding pocket; other site
999541004906	putative dimerization interface [polypeptide binding]; other site
999541004907	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
999541004908	homotrimer interaction site [polypeptide binding]; other site
999541004909	putative active site [active]
999541004910	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
999541004911	active site
999541004912	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541004913	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541004914	active site
999541004915	non-prolyl cis peptide bond; other site
999541004916	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
999541004917	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
999541004918	Flavin binding site [chemical binding]; other site
999541004919	AAA domain; Region: AAA_27; pfam13514
999541004920	AAA domain; Region: AAA_27; pfam13514
999541004921	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
999541004922	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541004923	active site
999541004924	metal binding site [ion binding]; metal-binding site
999541004925	DNA binding site [nucleotide binding]
999541004926	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
999541004927	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
999541004928	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
999541004929	active site
999541004930	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
999541004931	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
999541004932	metal binding site 2 [ion binding]; metal-binding site
999541004933	putative DNA binding helix; other site
999541004934	metal binding site 1 [ion binding]; metal-binding site
999541004935	dimer interface [polypeptide binding]; other site
999541004936	structural Zn2+ binding site [ion binding]; other site
999541004937	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
999541004938	putative FMN binding site [chemical binding]; other site
999541004939	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
999541004940	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541004941	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
999541004942	Walker A/P-loop; other site
999541004943	ATP binding site [chemical binding]; other site
999541004944	Q-loop/lid; other site
999541004945	ABC transporter signature motif; other site
999541004946	Walker B; other site
999541004947	D-loop; other site
999541004948	H-loop/switch region; other site
999541004949	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
999541004950	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
999541004951	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
999541004952	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
999541004953	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
999541004954	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
999541004955	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
999541004956	[4Fe-4S] binding site [ion binding]; other site
999541004957	molybdopterin cofactor binding site; other site
999541004958	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
999541004959	molybdopterin cofactor binding site; other site
999541004960	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
999541004961	Flavodoxin; Region: Flavodoxin_1; pfam00258
999541004962	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
999541004963	FAD binding pocket [chemical binding]; other site
999541004964	FAD binding motif [chemical binding]; other site
999541004965	catalytic residues [active]
999541004966	NAD binding pocket [chemical binding]; other site
999541004967	phosphate binding motif [ion binding]; other site
999541004968	beta-alpha-beta structure motif; other site
999541004969	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
999541004970	nitrite reductase subunit NirD; Provisional; Region: PRK14989
999541004971	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541004972	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
999541004973	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541004974	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
999541004975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541004976	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
999541004977	active site
999541004978	SAM binding site [chemical binding]; other site
999541004979	homodimer interface [polypeptide binding]; other site
999541004980	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
999541004981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541004982	active site
999541004983	phosphorylation site [posttranslational modification]
999541004984	intermolecular recognition site; other site
999541004985	dimerization interface [polypeptide binding]; other site
999541004986	ANTAR domain; Region: ANTAR; pfam03861
999541004987	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
999541004988	NMT1-like family; Region: NMT1_2; pfam13379
999541004989	Condensation domain; Region: Condensation; pfam00668
999541004990	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541004991	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541004992	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541004993	acyl-activating enzyme (AAE) consensus motif; other site
999541004994	AMP binding site [chemical binding]; other site
999541004995	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541004996	Condensation domain; Region: Condensation; pfam00668
999541004997	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
999541004998	Condensation domain; Region: Condensation; pfam00668
999541004999	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005000	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005001	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005002	acyl-activating enzyme (AAE) consensus motif; other site
999541005003	AMP binding site [chemical binding]; other site
999541005004	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005005	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541005006	acyl-activating enzyme (AAE) consensus motif; other site
999541005007	active site
999541005008	Condensation domain; Region: Condensation; pfam00668
999541005009	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005010	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005011	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005012	acyl-activating enzyme (AAE) consensus motif; other site
999541005013	AMP binding site [chemical binding]; other site
999541005014	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005015	Condensation domain; Region: Condensation; pfam00668
999541005016	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005017	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005018	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005019	acyl-activating enzyme (AAE) consensus motif; other site
999541005020	AMP binding site [chemical binding]; other site
999541005021	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005022	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
999541005023	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
999541005024	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541005025	N-terminal plug; other site
999541005026	ligand-binding site [chemical binding]; other site
999541005027	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
999541005028	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541005029	ABC-ATPase subunit  interface; other site
999541005030	dimer interface [polypeptide binding]; other site
999541005031	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541005032	ABC-ATPase subunit  interface; other site
999541005033	dimer interface [polypeptide binding]; other site
999541005034	putative PBP binding regions; other site
999541005035	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
999541005036	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
999541005037	intersubunit interface [polypeptide binding]; other site
999541005038	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
999541005039	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541005040	Walker A/P-loop; other site
999541005041	ATP binding site [chemical binding]; other site
999541005042	Q-loop/lid; other site
999541005043	ABC transporter signature motif; other site
999541005044	Walker B; other site
999541005045	D-loop; other site
999541005046	H-loop/switch region; other site
999541005047	Condensation domain; Region: Condensation; pfam00668
999541005048	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005049	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005050	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005051	acyl-activating enzyme (AAE) consensus motif; other site
999541005052	AMP binding site [chemical binding]; other site
999541005053	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005054	Condensation domain; Region: Condensation; pfam00668
999541005055	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
999541005056	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541005057	Condensation domain; Region: Condensation; pfam00668
999541005058	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005059	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005060	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005061	acyl-activating enzyme (AAE) consensus motif; other site
999541005062	AMP binding site [chemical binding]; other site
999541005063	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005064	Condensation domain; Region: Condensation; pfam00668
999541005065	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
999541005066	Condensation domain; Region: Condensation; pfam00668
999541005067	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005068	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005069	acyl-activating enzyme (AAE) consensus motif; other site
999541005070	AMP binding site [chemical binding]; other site
999541005071	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005072	Condensation domain; Region: Condensation; pfam00668
999541005073	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005074	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005075	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
999541005076	acyl-activating enzyme (AAE) consensus motif; other site
999541005077	AMP binding site [chemical binding]; other site
999541005078	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005079	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
999541005080	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541005081	MbtH-like protein; Region: MbtH; cl01279
999541005082	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
999541005083	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541005084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541005085	dimer interface [polypeptide binding]; other site
999541005086	putative CheW interface [polypeptide binding]; other site
999541005087	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
999541005088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005089	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
999541005090	dimerization interface [polypeptide binding]; other site
999541005091	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
999541005092	active site clefts [active]
999541005093	zinc binding site [ion binding]; other site
999541005094	dimer interface [polypeptide binding]; other site
999541005095	cyanate hydratase; Validated; Region: PRK02866
999541005096	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
999541005097	oligomer interface [polypeptide binding]; other site
999541005098	active site
999541005099	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541005100	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541005101	substrate binding pocket [chemical binding]; other site
999541005102	membrane-bound complex binding site; other site
999541005103	hinge residues; other site
999541005104	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005105	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541005106	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541005107	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541005108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005109	putative substrate translocation pore; other site
999541005110	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
999541005111	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541005112	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
999541005113	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
999541005114	substrate binding site [chemical binding]; other site
999541005115	isopropylmalate isomerase large subunit; Provisional; Region: PRK12466
999541005116	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
999541005117	substrate binding site [chemical binding]; other site
999541005118	ligand binding site [chemical binding]; other site
999541005119	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541005120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005121	transcriptional activator TtdR; Provisional; Region: PRK09801
999541005122	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
999541005123	putative effector binding pocket; other site
999541005124	putative dimerization interface [polypeptide binding]; other site
999541005125	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
999541005126	putative hydrophobic ligand binding site [chemical binding]; other site
999541005127	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541005128	dimerization interface [polypeptide binding]; other site
999541005129	putative DNA binding site [nucleotide binding]; other site
999541005130	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541005131	putative Zn2+ binding site [ion binding]; other site
999541005132	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
999541005133	DEAD-like helicases superfamily; Region: DEXDc; smart00487
999541005134	ATP binding site [chemical binding]; other site
999541005135	Mg++ binding site [ion binding]; other site
999541005136	motif III; other site
999541005137	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541005138	nucleotide binding region [chemical binding]; other site
999541005139	ATP-binding site [chemical binding]; other site
999541005140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541005141	HTH-like domain; Region: HTH_21; pfam13276
999541005142	Integrase core domain; Region: rve; pfam00665
999541005143	Integrase core domain; Region: rve_3; pfam13683
999541005144	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541005145	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
999541005146	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
999541005147	Na binding site [ion binding]; other site
999541005148	HD domain; Region: HD_5; pfam13487
999541005149	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541005150	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541005151	DNA binding residues [nucleotide binding]
999541005152	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541005153	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
999541005154	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
999541005155	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005156	MarR family; Region: MarR_2; cl17246
999541005157	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541005158	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541005160	Coenzyme A binding pocket [chemical binding]; other site
999541005161	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
999541005162	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
999541005163	Domain of unknown function (DUF802); Region: DUF802; pfam05650
999541005164	hypothetical protein; Provisional; Region: PRK09040
999541005165	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541005166	ligand binding site [chemical binding]; other site
999541005167	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
999541005168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541005169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541005170	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
999541005171	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541005172	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541005173	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541005174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005175	putative substrate translocation pore; other site
999541005176	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541005177	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
999541005178	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
999541005179	B12 binding site [chemical binding]; other site
999541005180	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541005181	FeS/SAM binding site; other site
999541005182	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
999541005183	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
999541005184	ligand binding site; other site
999541005185	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
999541005186	tellurium resistance terB-like protein; Region: terB_like; cd07177
999541005187	metal binding site [ion binding]; metal-binding site
999541005188	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541005189	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
999541005190	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
999541005191	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
999541005192	active site
999541005193	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
999541005194	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541005195	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541005196	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541005197	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541005198	LysR family transcriptional regulator; Provisional; Region: PRK14997
999541005199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005200	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541005201	putative effector binding pocket; other site
999541005202	dimerization interface [polypeptide binding]; other site
999541005203	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
999541005204	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541005205	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
999541005206	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541005207	MarR family; Region: MarR_2; cl17246
999541005208	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
999541005209	active site
999541005210	catalytic motif [active]
999541005211	Zn binding site [ion binding]; other site
999541005212	phosphopentomutase; Provisional; Region: PRK05362
999541005213	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
999541005214	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
999541005215	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
999541005216	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
999541005217	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
999541005218	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
999541005219	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
999541005220	Nucleoside recognition; Region: Gate; pfam07670
999541005221	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
999541005222	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
999541005223	phenylhydantoinase; Validated; Region: PRK08323
999541005224	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
999541005225	tetramer interface [polypeptide binding]; other site
999541005226	active site
999541005227	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
999541005228	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541005229	Na binding site [ion binding]; other site
999541005230	putative substrate binding site [chemical binding]; other site
999541005231	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
999541005232	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
999541005233	homodimer interface [polypeptide binding]; other site
999541005234	active site
999541005235	FMN binding site [chemical binding]; other site
999541005236	substrate binding site [chemical binding]; other site
999541005237	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
999541005238	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
999541005239	allantoate amidohydrolase; Reviewed; Region: PRK09290
999541005240	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
999541005241	active site
999541005242	metal binding site [ion binding]; metal-binding site
999541005243	dimer interface [polypeptide binding]; other site
999541005244	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
999541005245	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541005246	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
999541005247	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541005248	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541005249	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541005250	putative active site [active]
999541005251	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
999541005252	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541005253	Walker A/P-loop; other site
999541005254	ATP binding site [chemical binding]; other site
999541005255	Q-loop/lid; other site
999541005256	ABC transporter signature motif; other site
999541005257	Walker B; other site
999541005258	D-loop; other site
999541005259	H-loop/switch region; other site
999541005260	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
999541005261	hypothetical protein; Provisional; Region: PRK07483
999541005262	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541005263	inhibitor-cofactor binding pocket; inhibition site
999541005264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541005265	catalytic residue [active]
999541005266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005267	putative substrate translocation pore; other site
999541005268	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
999541005269	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541005270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005271	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
999541005272	putative substrate binding pocket [chemical binding]; other site
999541005273	putative dimerization interface [polypeptide binding]; other site
999541005274	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005275	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005276	acyl-activating enzyme (AAE) consensus motif; other site
999541005277	AMP binding site [chemical binding]; other site
999541005278	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
999541005279	NADPH bind site [chemical binding]; other site
999541005280	putative FMN binding site [chemical binding]; other site
999541005281	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541005282	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005283	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
999541005284	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541005285	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
999541005286	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
999541005287	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541005288	motif II; other site
999541005289	Protein of unknown function, DUF606; Region: DUF606; pfam04657
999541005290	Protein of unknown function, DUF606; Region: DUF606; pfam04657
999541005291	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
999541005292	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541005293	active site
999541005294	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
999541005295	GTPases - translation elongation factors [Translation, ribosomal structure and biogenesis]; Region: TufB; COG0050
999541005296	G1 box; other site
999541005297	putative GEF interaction site [polypeptide binding]; other site
999541005298	GTP/Mg2+ binding site [chemical binding]; other site
999541005299	Switch I region; other site
999541005300	G2 box; other site
999541005301	G3 box; other site
999541005302	Switch II region; other site
999541005303	G4 box; other site
999541005304	G5 box; other site
999541005305	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
999541005306	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
999541005307	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
999541005308	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
999541005309	selenocysteine synthase; Provisional; Region: PRK04311
999541005310	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
999541005311	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541005312	catalytic residue [active]
999541005313	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
999541005314	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
999541005315	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
999541005316	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
999541005317	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
999541005318	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
999541005319	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541005320	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541005321	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541005322	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
999541005323	molybdopterin cofactor binding site; other site
999541005324	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541005325	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
999541005326	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
999541005327	putative active site [active]
999541005328	Zn binding site [ion binding]; other site
999541005329	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
999541005330	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541005331	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541005332	trimer interface [polypeptide binding]; other site
999541005333	eyelet of channel; other site
999541005334	IHF dimer interface [polypeptide binding]; other site
999541005335	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
999541005336	IHF - DNA interface [nucleotide binding]; other site
999541005337	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
999541005338	active site
999541005339	tetramer interface; other site
999541005340	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541005341	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
999541005342	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541005343	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
999541005344	putative ADP-binding pocket [chemical binding]; other site
999541005345	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541005346	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
999541005347	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
999541005348	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
999541005349	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541005350	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
999541005351	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
999541005352	NADP-binding site; other site
999541005353	homotetramer interface [polypeptide binding]; other site
999541005354	substrate binding site [chemical binding]; other site
999541005355	homodimer interface [polypeptide binding]; other site
999541005356	active site
999541005357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541005358	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541005359	NAD(P) binding site [chemical binding]; other site
999541005360	active site
999541005361	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
999541005362	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
999541005363	homodimer interface [polypeptide binding]; other site
999541005364	substrate-cofactor binding pocket; other site
999541005365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541005366	catalytic residue [active]
999541005367	amidophosphoribosyltransferase; Provisional; Region: PRK09246
999541005368	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
999541005369	active site
999541005370	tetramer interface [polypeptide binding]; other site
999541005371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541005372	active site
999541005373	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
999541005374	Colicin V production protein; Region: Colicin_V; pfam02674
999541005375	Sporulation related domain; Region: SPOR; pfam05036
999541005376	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
999541005377	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541005378	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541005379	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
999541005380	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
999541005381	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
999541005382	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
999541005383	substrate binding site [chemical binding]; other site
999541005384	active site
999541005385	catalytic residues [active]
999541005386	heterodimer interface [polypeptide binding]; other site
999541005387	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
999541005388	DNA methylase; Region: N6_N4_Mtase; pfam01555
999541005389	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
999541005390	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
999541005391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541005392	catalytic residue [active]
999541005393	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
999541005394	active site
999541005395	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
999541005396	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
999541005397	dimerization interface 3.5A [polypeptide binding]; other site
999541005398	active site
999541005399	FimV N-terminal domain; Region: FimV_core; TIGR03505
999541005400	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
999541005401	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
999541005402	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
999541005403	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
999541005404	tartrate dehydrogenase; Region: TTC; TIGR02089
999541005405	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
999541005406	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
999541005407	substrate binding site [chemical binding]; other site
999541005408	Entericidin EcnA/B family; Region: Entericidin; cl02322
999541005409	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
999541005410	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
999541005411	substrate binding site [chemical binding]; other site
999541005412	ligand binding site [chemical binding]; other site
999541005413	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
999541005414	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
999541005415	tetramer interface [polypeptide binding]; other site
999541005416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541005417	catalytic residue [active]
999541005418	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541005419	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541005420	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541005421	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
999541005422	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541005423	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
999541005424	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
999541005425	dimer interface [polypeptide binding]; other site
999541005426	active site
999541005427	citrylCoA binding site [chemical binding]; other site
999541005428	NADH binding [chemical binding]; other site
999541005429	cationic pore residues; other site
999541005430	oxalacetate/citrate binding site [chemical binding]; other site
999541005431	coenzyme A binding site [chemical binding]; other site
999541005432	catalytic triad [active]
999541005433	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
999541005434	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
999541005435	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
999541005436	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
999541005437	L-aspartate oxidase; Provisional; Region: PRK06175
999541005438	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
999541005439	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
999541005440	SdhC subunit interface [polypeptide binding]; other site
999541005441	proximal heme binding site [chemical binding]; other site
999541005442	cardiolipin binding site; other site
999541005443	Iron-sulfur protein interface; other site
999541005444	proximal quinone binding site [chemical binding]; other site
999541005445	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
999541005446	Iron-sulfur protein interface; other site
999541005447	proximal quinone binding site [chemical binding]; other site
999541005448	SdhD (CybS) interface [polypeptide binding]; other site
999541005449	proximal heme binding site [chemical binding]; other site
999541005450	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
999541005451	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541005452	DNA-binding site [nucleotide binding]; DNA binding site
999541005453	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
999541005454	malate dehydrogenase; Provisional; Region: PRK05442
999541005455	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
999541005456	NAD(P) binding site [chemical binding]; other site
999541005457	dimer interface [polypeptide binding]; other site
999541005458	malate binding site [chemical binding]; other site
999541005459	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
999541005460	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
999541005461	2-methylcitrate dehydratase; Region: prpD; TIGR02330
999541005462	aconitate hydratase; Provisional; Region: acnA; PRK12881
999541005463	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
999541005464	substrate binding site [chemical binding]; other site
999541005465	ligand binding site [chemical binding]; other site
999541005466	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
999541005467	substrate binding site [chemical binding]; other site
999541005468	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541005469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005471	lipase chaperone; Provisional; Region: PRK01294
999541005472	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
999541005473	Lipase (class 2); Region: Lipase_2; pfam01674
999541005474	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
999541005475	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541005476	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541005477	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541005478	E3 interaction surface; other site
999541005479	lipoyl attachment site [posttranslational modification]; other site
999541005480	Cupin domain; Region: Cupin_2; cl17218
999541005481	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005482	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541005483	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
999541005484	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
999541005485	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541005486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541005487	S-adenosylmethionine binding site [chemical binding]; other site
999541005488	NAD-dependent deacetylase; Provisional; Region: PRK05333
999541005489	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
999541005490	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541005491	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541005492	Na binding site [ion binding]; other site
999541005493	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541005494	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541005495	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
999541005496	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541005497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541005498	DNA binding residues [nucleotide binding]
999541005499	dimerization interface [polypeptide binding]; other site
999541005500	aldehyde dehydrogenase; Provisional; Region: PRK11903
999541005501	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541005502	NAD(P) binding site [chemical binding]; other site
999541005503	catalytic residues [active]
999541005504	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
999541005505	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541005506	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541005507	DNA binding site [nucleotide binding]
999541005508	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
999541005509	putative ligand binding site [chemical binding]; other site
999541005510	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541005511	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
999541005512	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541005513	N-terminal plug; other site
999541005514	ligand-binding site [chemical binding]; other site
999541005515	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541005516	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
999541005517	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541005518	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541005519	catalytic residue [active]
999541005520	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541005521	MarR family; Region: MarR_2; cl17246
999541005522	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541005523	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541005524	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541005525	NAD(P) binding site [chemical binding]; other site
999541005526	catalytic residues [active]
999541005527	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541005528	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541005529	trimer interface [polypeptide binding]; other site
999541005530	eyelet of channel; other site
999541005531	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
999541005532	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
999541005533	dimer interface [polypeptide binding]; other site
999541005534	active site
999541005535	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
999541005536	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
999541005537	active site
999541005538	dimer interface [polypeptide binding]; other site
999541005539	metal binding site [ion binding]; metal-binding site
999541005540	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
999541005541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005542	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
999541005543	putative substrate translocation pore; other site
999541005544	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541005545	DNA-binding site [nucleotide binding]; DNA binding site
999541005546	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
999541005547	Outer membrane efflux protein; Region: OEP; pfam02321
999541005548	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
999541005549	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541005550	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
999541005551	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
999541005552	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
999541005553	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
999541005554	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
999541005555	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
999541005556	active site
999541005557	catalytic site [active]
999541005558	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
999541005559	peptidase domain interface [polypeptide binding]; other site
999541005560	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
999541005561	active site
999541005562	catalytic triad [active]
999541005563	calcium binding site [ion binding]; other site
999541005564	Cupin domain; Region: Cupin_2; cl17218
999541005565	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541005566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541005567	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
999541005568	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
999541005569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005570	putative substrate translocation pore; other site
999541005571	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
999541005572	active site
999541005573	DNA binding site [nucleotide binding]
999541005574	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
999541005575	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541005576	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005577	Epoxide hydrolase N terminus; Region: EHN; pfam06441
999541005578	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541005579	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
999541005580	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
999541005581	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
999541005582	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
999541005583	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541005584	catalytic residues [active]
999541005585	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541005586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
999541005587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541005588	ATP binding site [chemical binding]; other site
999541005589	Mg2+ binding site [ion binding]; other site
999541005590	G-X-G motif; other site
999541005591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541005592	Response regulator receiver domain; Region: Response_reg; pfam00072
999541005593	active site
999541005594	phosphorylation site [posttranslational modification]
999541005595	intermolecular recognition site; other site
999541005596	dimerization interface [polypeptide binding]; other site
999541005597	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
999541005598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541005599	active site
999541005600	phosphorylation site [posttranslational modification]
999541005601	intermolecular recognition site; other site
999541005602	dimerization interface [polypeptide binding]; other site
999541005603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541005604	DNA binding residues [nucleotide binding]
999541005605	dimerization interface [polypeptide binding]; other site
999541005606	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
999541005607	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
999541005608	activation loop (A-loop); other site
999541005609	Predicted ATPase [General function prediction only]; Region: COG3899
999541005610	AAA ATPase domain; Region: AAA_16; pfam13191
999541005611	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
999541005612	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
999541005613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541005614	dimer interface [polypeptide binding]; other site
999541005615	phosphorylation site [posttranslational modification]
999541005616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541005617	ATP binding site [chemical binding]; other site
999541005618	Mg2+ binding site [ion binding]; other site
999541005619	G-X-G motif; other site
999541005620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541005621	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541005622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541005623	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
999541005624	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005625	putative major fimbrial protein SthE; Provisional; Region: PRK15292
999541005626	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541005627	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541005628	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
999541005629	PapC N-terminal domain; Region: PapC_N; pfam13954
999541005630	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
999541005631	PapC C-terminal domain; Region: PapC_C; pfam13953
999541005632	putative chaperone protein EcpD; Provisional; Region: PRK09926
999541005633	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
999541005634	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
999541005635	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541005636	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
999541005637	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541005638	putative ligand binding site [chemical binding]; other site
999541005639	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541005640	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541005641	TM-ABC transporter signature motif; other site
999541005642	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541005643	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541005644	Walker A/P-loop; other site
999541005645	ATP binding site [chemical binding]; other site
999541005646	Q-loop/lid; other site
999541005647	ABC transporter signature motif; other site
999541005648	Walker B; other site
999541005649	D-loop; other site
999541005650	H-loop/switch region; other site
999541005651	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541005652	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541005653	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541005654	DNA binding site [nucleotide binding]
999541005655	domain linker motif; other site
999541005656	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
999541005657	dimerization interface [polypeptide binding]; other site
999541005658	ligand binding site [chemical binding]; other site
999541005659	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
999541005660	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
999541005661	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
999541005662	dimer interface [polypeptide binding]; other site
999541005663	ligand binding site [chemical binding]; other site
999541005664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541005665	dimerization interface [polypeptide binding]; other site
999541005666	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541005667	dimer interface [polypeptide binding]; other site
999541005668	putative CheW interface [polypeptide binding]; other site
999541005669	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
999541005670	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
999541005671	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
999541005672	DctM-like transporters; Region: DctM; pfam06808
999541005673	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
999541005674	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541005675	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541005676	DNA binding site [nucleotide binding]
999541005677	domain linker motif; other site
999541005678	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541005679	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
999541005680	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541005681	NAD binding site [chemical binding]; other site
999541005682	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541005683	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
999541005684	active site
999541005685	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
999541005686	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541005687	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541005688	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541005689	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541005690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541005691	dimer interface [polypeptide binding]; other site
999541005692	conserved gate region; other site
999541005693	putative PBP binding loops; other site
999541005694	ABC-ATPase subunit interface; other site
999541005695	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541005696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541005697	Walker A/P-loop; other site
999541005698	ATP binding site [chemical binding]; other site
999541005699	Q-loop/lid; other site
999541005700	ABC transporter signature motif; other site
999541005701	Walker B; other site
999541005702	D-loop; other site
999541005703	H-loop/switch region; other site
999541005704	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541005705	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541005706	active site
999541005707	non-prolyl cis peptide bond; other site
999541005708	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
999541005709	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
999541005710	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
999541005711	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541005712	N-terminal plug; other site
999541005713	ligand-binding site [chemical binding]; other site
999541005714	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541005715	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541005716	substrate binding pocket [chemical binding]; other site
999541005717	membrane-bound complex binding site; other site
999541005718	hinge residues; other site
999541005719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541005720	Coenzyme A binding pocket [chemical binding]; other site
999541005721	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
999541005722	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
999541005723	active site
999541005724	Zn binding site [ion binding]; other site
999541005725	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
999541005726	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
999541005727	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
999541005728	active site
999541005729	non-prolyl cis peptide bond; other site
999541005730	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541005731	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541005732	trimer interface [polypeptide binding]; other site
999541005733	eyelet of channel; other site
999541005734	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
999541005735	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541005736	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541005737	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
999541005738	active site
999541005739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541005740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005741	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
999541005742	putative dimerization interface [polypeptide binding]; other site
999541005743	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541005744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541005745	substrate binding pocket [chemical binding]; other site
999541005746	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
999541005747	membrane-bound complex binding site; other site
999541005748	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541005749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541005750	dimer interface [polypeptide binding]; other site
999541005751	conserved gate region; other site
999541005752	putative PBP binding loops; other site
999541005753	ABC-ATPase subunit interface; other site
999541005754	short chain dehydrogenase; Provisional; Region: PRK06125
999541005755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541005756	NAD(P) binding site [chemical binding]; other site
999541005757	active site
999541005758	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
999541005759	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
999541005760	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
999541005761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541005762	Walker A/P-loop; other site
999541005763	ATP binding site [chemical binding]; other site
999541005764	Q-loop/lid; other site
999541005765	ABC transporter signature motif; other site
999541005766	Walker B; other site
999541005767	D-loop; other site
999541005768	H-loop/switch region; other site
999541005769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541005770	Walker A/P-loop; other site
999541005771	ATP binding site [chemical binding]; other site
999541005772	Q-loop/lid; other site
999541005773	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
999541005774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541005775	Walker A/P-loop; other site
999541005776	ATP binding site [chemical binding]; other site
999541005777	Q-loop/lid; other site
999541005778	ABC transporter signature motif; other site
999541005779	Walker B; other site
999541005780	D-loop; other site
999541005781	H-loop/switch region; other site
999541005782	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
999541005783	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
999541005784	DNA binding residues [nucleotide binding]
999541005785	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
999541005786	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541005787	Serine hydrolase; Region: Ser_hydrolase; cl17834
999541005788	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
999541005789	Cupin domain; Region: Cupin_2; pfam07883
999541005790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541005791	PAS fold; Region: PAS_3; pfam08447
999541005792	putative active site [active]
999541005793	heme pocket [chemical binding]; other site
999541005794	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541005795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541005796	metal binding site [ion binding]; metal-binding site
999541005797	active site
999541005798	I-site; other site
999541005799	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541005800	PLD-like domain; Region: PLDc_2; pfam13091
999541005801	putative active site [active]
999541005802	catalytic site [active]
999541005803	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541005804	PLD-like domain; Region: PLDc_2; pfam13091
999541005805	putative active site [active]
999541005806	catalytic site [active]
999541005807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541005808	PAS domain; Region: PAS_9; pfam13426
999541005809	putative active site [active]
999541005810	heme pocket [chemical binding]; other site
999541005811	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541005812	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541005813	dimer interface [polypeptide binding]; other site
999541005814	putative CheW interface [polypeptide binding]; other site
999541005815	cheY-homologous receiver domain; Region: REC; smart00448
999541005816	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541005817	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
999541005818	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
999541005819	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
999541005820	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
999541005821	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541005822	ligand binding site [chemical binding]; other site
999541005823	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
999541005824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541005825	active site
999541005826	phosphorylation site [posttranslational modification]
999541005827	intermolecular recognition site; other site
999541005828	dimerization interface [polypeptide binding]; other site
999541005829	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541005830	DNA binding site [nucleotide binding]
999541005831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541005832	dimer interface [polypeptide binding]; other site
999541005833	phosphorylation site [posttranslational modification]
999541005834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541005835	ATP binding site [chemical binding]; other site
999541005836	Mg2+ binding site [ion binding]; other site
999541005837	G-X-G motif; other site
999541005838	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541005839	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
999541005840	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541005841	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541005842	catalytic residue [active]
999541005843	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
999541005844	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541005845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541005846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541005848	dimerization interface [polypeptide binding]; other site
999541005849	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
999541005850	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
999541005851	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541005852	N-terminal plug; other site
999541005853	ligand-binding site [chemical binding]; other site
999541005854	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541005855	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
999541005856	substrate binding site [chemical binding]; other site
999541005857	dimer interface [polypeptide binding]; other site
999541005858	ATP binding site [chemical binding]; other site
999541005859	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
999541005860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005862	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
999541005863	active site
999541005864	catalytic residues [active]
999541005865	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
999541005866	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
999541005867	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541005868	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
999541005869	intersubunit interface [polypeptide binding]; other site
999541005870	active site
999541005871	catalytic residue [active]
999541005872	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
999541005873	oligomeric interface; other site
999541005874	putative active site [active]
999541005875	homodimer interface [polypeptide binding]; other site
999541005876	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541005877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541005878	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541005879	dimerization interface [polypeptide binding]; other site
999541005880	substrate binding pocket [chemical binding]; other site
999541005881	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
999541005882	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541005883	acyl-activating enzyme (AAE) consensus motif; other site
999541005884	AMP binding site [chemical binding]; other site
999541005885	active site
999541005886	CoA binding site [chemical binding]; other site
999541005887	Putative addiction module component; Region: Unstab_antitox; cl09921
999541005888	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541005889	dinuclear metal binding motif [ion binding]; other site
999541005890	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541005891	FAD binding domain; Region: FAD_binding_4; pfam01565
999541005892	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
999541005893	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541005894	putative di-iron ligands [ion binding]; other site
999541005895	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
999541005896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541005897	putative substrate translocation pore; other site
999541005898	Condensation domain; Region: Condensation; pfam00668
999541005899	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005900	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005901	acyl-activating enzyme (AAE) consensus motif; other site
999541005902	AMP binding site [chemical binding]; other site
999541005903	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005904	Condensation domain; Region: Condensation; pfam00668
999541005905	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541005906	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541005907	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541005908	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005909	acyl-activating enzyme (AAE) consensus motif; other site
999541005910	AMP binding site [chemical binding]; other site
999541005911	active site
999541005912	CoA binding site [chemical binding]; other site
999541005913	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005914	Condensation domain; Region: Condensation; pfam00668
999541005915	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541005916	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541005917	acyl-activating enzyme (AAE) consensus motif; other site
999541005918	AMP binding site [chemical binding]; other site
999541005919	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541005920	MbtH-like protein; Region: MbtH; pfam03621
999541005921	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
999541005922	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
999541005923	dinuclear metal binding motif [ion binding]; other site
999541005924	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
999541005925	active site
999541005926	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
999541005927	catalytic residue [active]
999541005928	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
999541005929	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
999541005930	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541005931	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541005932	acyl-activating enzyme (AAE) consensus motif; other site
999541005933	acyl-activating enzyme (AAE) consensus motif; other site
999541005934	AMP binding site [chemical binding]; other site
999541005935	active site
999541005936	CoA binding site [chemical binding]; other site
999541005937	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541005938	active site
999541005939	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
999541005940	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
999541005941	citrylCoA binding site [chemical binding]; other site
999541005942	oxalacetate binding site [chemical binding]; other site
999541005943	coenzyme A binding site [chemical binding]; other site
999541005944	catalytic triad [active]
999541005945	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541005946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541005947	S-adenosylmethionine binding site [chemical binding]; other site
999541005948	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
999541005949	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
999541005950	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541005951	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
999541005952	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
999541005953	NAD binding site [chemical binding]; other site
999541005954	catalytic Zn binding site [ion binding]; other site
999541005955	structural Zn binding site [ion binding]; other site
999541005956	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
999541005957	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
999541005958	putative molybdopterin cofactor binding site [chemical binding]; other site
999541005959	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
999541005960	putative molybdopterin cofactor binding site; other site
999541005961	oxidoreductase; Provisional; Region: PRK06128
999541005962	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
999541005963	NAD binding site [chemical binding]; other site
999541005964	metal binding site [ion binding]; metal-binding site
999541005965	active site
999541005966	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
999541005967	BON domain; Region: BON; pfam04972
999541005968	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
999541005969	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
999541005970	putative ADP-binding pocket [chemical binding]; other site
999541005971	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541005972	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
999541005973	NAD binding site [chemical binding]; other site
999541005974	putative substrate binding site 2 [chemical binding]; other site
999541005975	putative substrate binding site 1 [chemical binding]; other site
999541005976	active site
999541005977	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
999541005978	Fe-S cluster binding site [ion binding]; other site
999541005979	active site
999541005980	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
999541005981	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541005982	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
999541005983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541005984	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541005985	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
999541005986	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541005987	putative active site [active]
999541005988	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541005989	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541005990	active site
999541005991	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
999541005992	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
999541005993	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
999541005994	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
999541005995	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541005996	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541005997	putative active site [active]
999541005998	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
999541005999	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541006000	active site
999541006001	motif I; other site
999541006002	motif II; other site
999541006003	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
999541006004	classical (c) SDRs; Region: SDR_c; cd05233
999541006005	NAD(P) binding site [chemical binding]; other site
999541006006	active site
999541006007	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
999541006008	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
999541006009	NAD binding site [chemical binding]; other site
999541006010	catalytic Zn binding site [ion binding]; other site
999541006011	structural Zn binding site [ion binding]; other site
999541006012	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541006013	active site
999541006014	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541006015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006016	active site
999541006017	phosphorylation site [posttranslational modification]
999541006018	intermolecular recognition site; other site
999541006019	dimerization interface [polypeptide binding]; other site
999541006020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541006021	Walker A motif; other site
999541006022	ATP binding site [chemical binding]; other site
999541006023	Walker B motif; other site
999541006024	arginine finger; other site
999541006025	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541006026	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541006027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541006028	Walker A motif; other site
999541006029	ATP binding site [chemical binding]; other site
999541006030	Walker B motif; other site
999541006031	arginine finger; other site
999541006032	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541006033	FOG: CBS domain [General function prediction only]; Region: COG0517
999541006034	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
999541006035	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541006036	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
999541006037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541006038	Walker A/P-loop; other site
999541006039	ATP binding site [chemical binding]; other site
999541006040	Q-loop/lid; other site
999541006041	ABC transporter signature motif; other site
999541006042	Walker B; other site
999541006043	D-loop; other site
999541006044	H-loop/switch region; other site
999541006045	Response regulator receiver domain; Region: Response_reg; pfam00072
999541006046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006047	active site
999541006048	phosphorylation site [posttranslational modification]
999541006049	intermolecular recognition site; other site
999541006050	dimerization interface [polypeptide binding]; other site
999541006051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541006052	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
999541006053	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541006054	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541006055	active site
999541006056	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541006057	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
999541006058	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541006059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006060	active site
999541006061	phosphorylation site [posttranslational modification]
999541006062	intermolecular recognition site; other site
999541006063	dimerization interface [polypeptide binding]; other site
999541006064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541006065	Walker A motif; other site
999541006066	ATP binding site [chemical binding]; other site
999541006067	Walker B motif; other site
999541006068	arginine finger; other site
999541006069	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541006070	GAF domain; Region: GAF_3; pfam13492
999541006071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541006072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006073	dimer interface [polypeptide binding]; other site
999541006074	phosphorylation site [posttranslational modification]
999541006075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006076	ATP binding site [chemical binding]; other site
999541006077	Mg2+ binding site [ion binding]; other site
999541006078	G-X-G motif; other site
999541006079	Response regulator receiver domain; Region: Response_reg; pfam00072
999541006080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006081	active site
999541006082	phosphorylation site [posttranslational modification]
999541006083	intermolecular recognition site; other site
999541006084	dimerization interface [polypeptide binding]; other site
999541006085	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
999541006086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006087	dimer interface [polypeptide binding]; other site
999541006088	phosphorylation site [posttranslational modification]
999541006089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006090	ATP binding site [chemical binding]; other site
999541006091	Mg2+ binding site [ion binding]; other site
999541006092	G-X-G motif; other site
999541006093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541006095	active site
999541006096	phosphorylation site [posttranslational modification]
999541006097	intermolecular recognition site; other site
999541006098	dimerization interface [polypeptide binding]; other site
999541006099	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
999541006100	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541006101	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
999541006102	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541006103	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
999541006104	putative active site pocket [active]
999541006105	putative metal binding site [ion binding]; other site
999541006106	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
999541006107	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
999541006108	Cytochrome c; Region: Cytochrom_C; pfam00034
999541006109	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
999541006110	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
999541006111	D-pathway; other site
999541006112	Putative ubiquinol binding site [chemical binding]; other site
999541006113	Low-spin heme (heme b) binding site [chemical binding]; other site
999541006114	Putative water exit pathway; other site
999541006115	Binuclear center (heme o3/CuB) [ion binding]; other site
999541006116	K-pathway; other site
999541006117	Putative proton exit pathway; other site
999541006118	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
999541006119	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541006120	Cytochrome c; Region: Cytochrom_C; pfam00034
999541006121	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575
999541006122	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
999541006123	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541006124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006125	NAD(P) binding site [chemical binding]; other site
999541006126	active site
999541006127	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
999541006128	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
999541006129	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
999541006130	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
999541006131	dimanganese center [ion binding]; other site
999541006132	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541006133	dinuclear metal binding motif [ion binding]; other site
999541006134	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
999541006135	nudix motif; other site
999541006136	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
999541006137	dimerization interface [polypeptide binding]; other site
999541006138	metal binding site [ion binding]; metal-binding site
999541006139	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
999541006140	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
999541006141	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
999541006142	NAD binding site [chemical binding]; other site
999541006143	catalytic Zn binding site [ion binding]; other site
999541006144	structural Zn binding site [ion binding]; other site
999541006145	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
999541006146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541006147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006148	dimer interface [polypeptide binding]; other site
999541006149	phosphorylation site [posttranslational modification]
999541006150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006151	ATP binding site [chemical binding]; other site
999541006152	Mg2+ binding site [ion binding]; other site
999541006153	G-X-G motif; other site
999541006154	PAS fold; Region: PAS_3; pfam08447
999541006155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541006156	heme pocket [chemical binding]; other site
999541006157	putative active site [active]
999541006158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541006159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006160	dimer interface [polypeptide binding]; other site
999541006161	phosphorylation site [posttranslational modification]
999541006162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006163	ATP binding site [chemical binding]; other site
999541006164	Mg2+ binding site [ion binding]; other site
999541006165	G-X-G motif; other site
999541006166	Response regulator receiver domain; Region: Response_reg; pfam00072
999541006167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006168	active site
999541006169	phosphorylation site [posttranslational modification]
999541006170	intermolecular recognition site; other site
999541006171	dimerization interface [polypeptide binding]; other site
999541006172	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541006173	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
999541006174	putative dimer interface [polypeptide binding]; other site
999541006175	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541006176	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
999541006177	putative dimer interface [polypeptide binding]; other site
999541006178	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
999541006179	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
999541006180	active site
999541006181	homotetramer interface [polypeptide binding]; other site
999541006182	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
999541006183	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
999541006184	active site
999541006185	DNA binding site [nucleotide binding]
999541006186	Int/Topo IB signature motif; other site
999541006187	catalytic residues [active]
999541006188	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
999541006189	Strictosidine synthase; Region: Str_synth; pfam03088
999541006190	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
999541006191	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
999541006192	NAD(P) binding site [chemical binding]; other site
999541006193	catalytic residues [active]
999541006194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006196	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
999541006197	putative dimerization interface [polypeptide binding]; other site
999541006198	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
999541006199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541006200	D-galactonate transporter; Region: 2A0114; TIGR00893
999541006201	putative substrate translocation pore; other site
999541006202	short chain dehydrogenase; Provisional; Region: PRK12829
999541006203	classical (c) SDRs; Region: SDR_c; cd05233
999541006204	NAD(P) binding site [chemical binding]; other site
999541006205	active site
999541006206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541006207	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541006208	salt bridge; other site
999541006209	non-specific DNA binding site [nucleotide binding]; other site
999541006210	sequence-specific DNA binding site [nucleotide binding]; other site
999541006211	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541006212	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
999541006213	NAD(P) binding site [chemical binding]; other site
999541006214	active site
999541006215	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
999541006216	Serine hydrolase; Region: Ser_hydrolase; cl17834
999541006217	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541006218	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541006219	substrate binding pocket [chemical binding]; other site
999541006220	membrane-bound complex binding site; other site
999541006221	hinge residues; other site
999541006222	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541006223	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541006224	DNA-binding site [nucleotide binding]; DNA binding site
999541006225	FCD domain; Region: FCD; pfam07729
999541006226	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
999541006227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541006228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541006229	Tannase and feruloyl esterase; Region: Tannase; pfam07519
999541006230	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541006231	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
999541006232	NADP binding site [chemical binding]; other site
999541006233	putative substrate binding site [chemical binding]; other site
999541006234	active site
999541006235	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
999541006236	Sodium Bile acid symporter family; Region: SBF; pfam01758
999541006237	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
999541006238	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541006239	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
999541006240	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541006241	putative DNA binding site [nucleotide binding]; other site
999541006242	putative Zn2+ binding site [ion binding]; other site
999541006243	AsnC family; Region: AsnC_trans_reg; pfam01037
999541006244	hypothetical protein; Provisional; Region: PRK07482
999541006245	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541006246	inhibitor-cofactor binding pocket; inhibition site
999541006247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541006248	catalytic residue [active]
999541006249	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541006250	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541006251	tetramerization interface [polypeptide binding]; other site
999541006252	NAD(P) binding site [chemical binding]; other site
999541006253	catalytic residues [active]
999541006254	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
999541006255	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
999541006256	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541006257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006258	dimer interface [polypeptide binding]; other site
999541006259	conserved gate region; other site
999541006260	putative PBP binding loops; other site
999541006261	ABC-ATPase subunit interface; other site
999541006262	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
999541006263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541006264	Walker A/P-loop; other site
999541006265	ATP binding site [chemical binding]; other site
999541006266	Q-loop/lid; other site
999541006267	ABC transporter signature motif; other site
999541006268	Walker B; other site
999541006269	D-loop; other site
999541006270	H-loop/switch region; other site
999541006271	NIPSNAP; Region: NIPSNAP; pfam07978
999541006272	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541006273	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
999541006274	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
999541006275	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
999541006276	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541006277	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
999541006278	NAD(P) binding site [chemical binding]; other site
999541006279	catalytic residues [active]
999541006280	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
999541006281	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
999541006282	nudix motif; other site
999541006283	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
999541006284	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
999541006285	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
999541006286	Amino acid synthesis; Region: AA_synth; pfam06684
999541006287	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
999541006288	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
999541006289	putative ligand binding site [chemical binding]; other site
999541006290	NAD binding site [chemical binding]; other site
999541006291	dimerization interface [polypeptide binding]; other site
999541006292	catalytic site [active]
999541006293	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541006294	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541006295	trimer interface [polypeptide binding]; other site
999541006296	eyelet of channel; other site
999541006297	hypothetical protein; Provisional; Region: PRK05965
999541006298	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541006299	inhibitor-cofactor binding pocket; inhibition site
999541006300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541006301	catalytic residue [active]
999541006302	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
999541006303	galactarate dehydratase; Region: galactar-dH20; TIGR03248
999541006304	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
999541006305	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
999541006306	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541006307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541006308	DNA-binding site [nucleotide binding]; DNA binding site
999541006309	FCD domain; Region: FCD; pfam07729
999541006310	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
999541006311	succinic semialdehyde dehydrogenase; Region: PLN02278
999541006312	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541006313	tetramerization interface [polypeptide binding]; other site
999541006314	NAD(P) binding site [chemical binding]; other site
999541006315	catalytic residues [active]
999541006316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541006317	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541006318	putative substrate translocation pore; other site
999541006319	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
999541006320	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541006321	substrate binding site [chemical binding]; other site
999541006322	oxyanion hole (OAH) forming residues; other site
999541006323	trimer interface [polypeptide binding]; other site
999541006324	enoyl-CoA hydratase; Provisional; Region: PRK05862
999541006325	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541006326	substrate binding site [chemical binding]; other site
999541006327	oxyanion hole (OAH) forming residues; other site
999541006328	trimer interface [polypeptide binding]; other site
999541006329	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541006330	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541006331	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541006332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006333	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541006334	dimerization interface [polypeptide binding]; other site
999541006335	substrate binding pocket [chemical binding]; other site
999541006336	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
999541006337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541006338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541006339	putative substrate translocation pore; other site
999541006340	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541006341	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541006342	trimer interface [polypeptide binding]; other site
999541006343	eyelet of channel; other site
999541006344	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541006345	extended (e) SDRs; Region: SDR_e; cd08946
999541006346	NAD(P) binding site [chemical binding]; other site
999541006347	active site
999541006348	substrate binding site [chemical binding]; other site
999541006349	dihydropyrimidinase; Provisional; Region: PRK13404
999541006350	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
999541006351	tetramer interface [polypeptide binding]; other site
999541006352	active site
999541006353	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541006354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006355	dimer interface [polypeptide binding]; other site
999541006356	conserved gate region; other site
999541006357	putative PBP binding loops; other site
999541006358	ABC-ATPase subunit interface; other site
999541006359	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541006360	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541006361	substrate binding pocket [chemical binding]; other site
999541006362	membrane-bound complex binding site; other site
999541006363	hinge residues; other site
999541006364	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
999541006365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006366	NAD(P) binding site [chemical binding]; other site
999541006367	active site
999541006368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006369	NAD(P) binding site [chemical binding]; other site
999541006370	active site
999541006371	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541006372	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541006373	Walker A/P-loop; other site
999541006374	ATP binding site [chemical binding]; other site
999541006375	Q-loop/lid; other site
999541006376	ABC transporter signature motif; other site
999541006377	Walker B; other site
999541006378	D-loop; other site
999541006379	H-loop/switch region; other site
999541006380	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
999541006381	classical (c) SDRs; Region: SDR_c; cd05233
999541006382	NAD(P) binding site [chemical binding]; other site
999541006383	active site
999541006384	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
999541006385	extended (e) SDRs; Region: SDR_e; cd08946
999541006386	NAD(P) binding site [chemical binding]; other site
999541006387	active site
999541006388	substrate binding site [chemical binding]; other site
999541006389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006390	dimer interface [polypeptide binding]; other site
999541006391	conserved gate region; other site
999541006392	putative PBP binding loops; other site
999541006393	ABC-ATPase subunit interface; other site
999541006394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006395	dimer interface [polypeptide binding]; other site
999541006396	conserved gate region; other site
999541006397	putative PBP binding loops; other site
999541006398	ABC-ATPase subunit interface; other site
999541006399	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541006400	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541006401	substrate binding pocket [chemical binding]; other site
999541006402	membrane-bound complex binding site; other site
999541006403	hinge residues; other site
999541006404	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
999541006405	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
999541006406	active site
999541006407	catalytic site [active]
999541006408	tetramer interface [polypeptide binding]; other site
999541006409	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
999541006410	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
999541006411	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
999541006412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006413	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
999541006414	putative dimerization interface [polypeptide binding]; other site
999541006415	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541006416	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541006417	Walker A/P-loop; other site
999541006418	ATP binding site [chemical binding]; other site
999541006419	Q-loop/lid; other site
999541006420	ABC transporter signature motif; other site
999541006421	Walker B; other site
999541006422	D-loop; other site
999541006423	H-loop/switch region; other site
999541006424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006425	dimer interface [polypeptide binding]; other site
999541006426	conserved gate region; other site
999541006427	ABC-ATPase subunit interface; other site
999541006428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006429	dimer interface [polypeptide binding]; other site
999541006430	conserved gate region; other site
999541006431	putative PBP binding loops; other site
999541006432	ABC-ATPase subunit interface; other site
999541006433	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541006434	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541006435	substrate binding pocket [chemical binding]; other site
999541006436	membrane-bound complex binding site; other site
999541006437	hinge residues; other site
999541006438	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541006439	homotrimer interaction site [polypeptide binding]; other site
999541006440	putative active site [active]
999541006441	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541006442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541006443	DNA-binding site [nucleotide binding]; DNA binding site
999541006444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541006445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541006446	homodimer interface [polypeptide binding]; other site
999541006447	catalytic residue [active]
999541006448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541006449	S-adenosylmethionine binding site [chemical binding]; other site
999541006450	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
999541006451	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
999541006452	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
999541006453	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
999541006454	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
999541006455	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541006456	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
999541006457	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541006458	DNA binding residues [nucleotide binding]
999541006459	DNA primase; Validated; Region: dnaG; PRK05667
999541006460	CHC2 zinc finger; Region: zf-CHC2; pfam01807
999541006461	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
999541006462	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
999541006463	active site
999541006464	metal binding site [ion binding]; metal-binding site
999541006465	interdomain interaction site; other site
999541006466	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
999541006467	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
999541006468	Yqey-like protein; Region: YqeY; pfam09424
999541006469	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
999541006470	HI0933-like protein; Region: HI0933_like; pfam03486
999541006471	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
999541006472	UGMP family protein; Validated; Region: PRK09604
999541006473	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
999541006474	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
999541006475	putative GTP cyclohydrolase; Provisional; Region: PRK13674
999541006476	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
999541006477	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
999541006478	TPP-binding site; other site
999541006479	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
999541006480	PYR/PP interface [polypeptide binding]; other site
999541006481	dimer interface [polypeptide binding]; other site
999541006482	TPP binding site [chemical binding]; other site
999541006483	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
999541006484	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
999541006485	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
999541006486	substrate binding pocket [chemical binding]; other site
999541006487	chain length determination region; other site
999541006488	substrate-Mg2+ binding site; other site
999541006489	catalytic residues [active]
999541006490	aspartate-rich region 1; other site
999541006491	active site lid residues [active]
999541006492	aspartate-rich region 2; other site
999541006493	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
999541006494	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541006495	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541006496	[2Fe-2S] cluster binding site [ion binding]; other site
999541006497	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
999541006498	alpha subunit interface [polypeptide binding]; other site
999541006499	active site
999541006500	substrate binding site [chemical binding]; other site
999541006501	Fe binding site [ion binding]; other site
999541006502	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
999541006503	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
999541006504	active site residue [active]
999541006505	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
999541006506	active site residue [active]
999541006507	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
999541006508	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
999541006509	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
999541006510	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541006511	DNA polymerase I; Provisional; Region: PRK05755
999541006512	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
999541006513	active site
999541006514	metal binding site 1 [ion binding]; metal-binding site
999541006515	putative 5' ssDNA interaction site; other site
999541006516	metal binding site 3; metal-binding site
999541006517	metal binding site 2 [ion binding]; metal-binding site
999541006518	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
999541006519	putative DNA binding site [nucleotide binding]; other site
999541006520	putative metal binding site [ion binding]; other site
999541006521	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
999541006522	active site
999541006523	catalytic site [active]
999541006524	substrate binding site [chemical binding]; other site
999541006525	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
999541006526	active site
999541006527	DNA binding site [nucleotide binding]
999541006528	catalytic site [active]
999541006529	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
999541006530	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541006531	AMP nucleosidase; Provisional; Region: PRK08292
999541006532	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
999541006533	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
999541006534	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
999541006535	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
999541006536	putative active site [active]
999541006537	putative substrate binding site [chemical binding]; other site
999541006538	ATP binding site [chemical binding]; other site
999541006539	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541006540	MarR family; Region: MarR; pfam01047
999541006541	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
999541006542	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
999541006543	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
999541006544	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
999541006545	Tautomerase enzyme; Region: Tautomerase; pfam01361
999541006546	active site 1 [active]
999541006547	dimer interface [polypeptide binding]; other site
999541006548	hexamer interface [polypeptide binding]; other site
999541006549	active site 2 [active]
999541006550	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541006551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006553	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541006554	dimerization interface [polypeptide binding]; other site
999541006555	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541006556	EamA-like transporter family; Region: EamA; pfam00892
999541006557	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541006558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006559	dimer interface [polypeptide binding]; other site
999541006560	phosphorylation site [posttranslational modification]
999541006561	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
999541006562	Domain of unknown function DUF21; Region: DUF21; pfam01595
999541006563	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
999541006564	Transporter associated domain; Region: CorC_HlyC; smart01091
999541006565	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541006566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006567	NAD(P) binding site [chemical binding]; other site
999541006568	active site
999541006569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006570	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006571	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541006572	dimerization interface [polypeptide binding]; other site
999541006573	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
999541006574	thiamine phosphate binding site [chemical binding]; other site
999541006575	active site
999541006576	pyrophosphate binding site [ion binding]; other site
999541006577	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
999541006578	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
999541006579	active site
999541006580	catalytic site [active]
999541006581	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
999541006582	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
999541006583	active site
999541006584	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541006585	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
999541006586	putative C-terminal domain interface [polypeptide binding]; other site
999541006587	putative GSH binding site (G-site) [chemical binding]; other site
999541006588	putative dimer interface [polypeptide binding]; other site
999541006589	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
999541006590	putative N-terminal domain interface [polypeptide binding]; other site
999541006591	putative dimer interface [polypeptide binding]; other site
999541006592	putative substrate binding pocket (H-site) [chemical binding]; other site
999541006593	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
999541006594	RES domain; Region: RES; smart00953
999541006595	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
999541006596	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
999541006597	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
999541006598	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541006599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006600	active site
999541006601	phosphorylation site [posttranslational modification]
999541006602	dimerization interface [polypeptide binding]; other site
999541006603	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541006604	DNA binding site [nucleotide binding]
999541006605	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
999541006606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541006607	dimerization interface [polypeptide binding]; other site
999541006608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006609	dimer interface [polypeptide binding]; other site
999541006610	phosphorylation site [posttranslational modification]
999541006611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006612	ATP binding site [chemical binding]; other site
999541006613	G-X-G motif; other site
999541006614	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
999541006615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006616	active site
999541006617	phosphorylation site [posttranslational modification]
999541006618	intermolecular recognition site; other site
999541006619	dimerization interface [polypeptide binding]; other site
999541006620	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541006621	DNA binding site [nucleotide binding]
999541006622	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
999541006623	AAA domain; Region: AAA_18; pfam13238
999541006624	active site
999541006625	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
999541006626	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
999541006627	AP (apurinic/apyrimidinic) site pocket; other site
999541006628	DNA interaction; other site
999541006629	Metal-binding active site; metal-binding site
999541006630	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541006631	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541006632	TM-ABC transporter signature motif; other site
999541006633	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541006634	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541006635	TM-ABC transporter signature motif; other site
999541006636	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541006637	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541006638	Walker A/P-loop; other site
999541006639	ATP binding site [chemical binding]; other site
999541006640	Q-loop/lid; other site
999541006641	ABC transporter signature motif; other site
999541006642	Walker B; other site
999541006643	D-loop; other site
999541006644	H-loop/switch region; other site
999541006645	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541006646	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
999541006647	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541006648	ligand binding site [chemical binding]; other site
999541006649	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541006650	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541006651	DNA binding site [nucleotide binding]
999541006652	domain linker motif; other site
999541006653	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541006654	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
999541006655	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
999541006656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541006657	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541006658	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541006659	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
999541006660	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541006661	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541006662	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
999541006663	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541006664	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541006665	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541006666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541006667	active site
999541006668	tyrosine kinase; Provisional; Region: PRK11519
999541006669	Chain length determinant protein; Region: Wzz; cl15801
999541006670	Chain length determinant protein; Region: Wzz; cl15801
999541006671	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
999541006672	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541006673	P-loop; other site
999541006674	Magnesium ion binding site [ion binding]; other site
999541006675	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
999541006676	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541006677	SLBB domain; Region: SLBB; pfam10531
999541006678	SLBB domain; Region: SLBB; pfam10531
999541006679	Low molecular weight phosphatase family; Region: LMWPc; cd00115
999541006680	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
999541006681	active site
999541006682	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
999541006683	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
999541006684	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
999541006685	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
999541006686	Bacterial sugar transferase; Region: Bac_transf; pfam02397
999541006687	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
999541006688	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
999541006689	Substrate binding site; other site
999541006690	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
999541006691	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
999541006692	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
999541006693	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
999541006694	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
999541006695	Autotransporter beta-domain; Region: Autotransporter; pfam03797
999541006696	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
999541006697	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541006698	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
999541006699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
999541006700	YCII-related domain; Region: YCII; cl00999
999541006701	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
999541006702	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
999541006703	generic binding surface II; other site
999541006704	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
999541006705	putative active site [active]
999541006706	putative catalytic site [active]
999541006707	putative Mg binding site IVb [ion binding]; other site
999541006708	putative phosphate binding site [ion binding]; other site
999541006709	putative DNA binding site [nucleotide binding]; other site
999541006710	putative Mg binding site IVa [ion binding]; other site
999541006711	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
999541006712	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
999541006713	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
999541006714	Domain of unknown function DUF20; Region: UPF0118; pfam01594
999541006715	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
999541006716	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541006717	N-terminal plug; other site
999541006718	ligand-binding site [chemical binding]; other site
999541006719	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
999541006720	Prostaglandin dehydrogenases; Region: PGDH; cd05288
999541006721	NAD(P) binding site [chemical binding]; other site
999541006722	substrate binding site [chemical binding]; other site
999541006723	dimer interface [polypeptide binding]; other site
999541006724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006725	short chain dehydrogenase; Validated; Region: PRK07069
999541006726	NAD(P) binding site [chemical binding]; other site
999541006727	active site
999541006728	short chain dehydrogenase; Provisional; Region: PRK07035
999541006729	classical (c) SDRs; Region: SDR_c; cd05233
999541006730	NAD(P) binding site [chemical binding]; other site
999541006731	active site
999541006732	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541006733	catalytic core [active]
999541006734	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
999541006735	Phosphotransferase enzyme family; Region: APH; pfam01636
999541006736	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
999541006737	putative active site [active]
999541006738	putative substrate binding site [chemical binding]; other site
999541006739	ATP binding site [chemical binding]; other site
999541006740	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541006741	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541006742	active site
999541006743	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006745	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
999541006746	substrate binding pocket [chemical binding]; other site
999541006747	dimerization interface [polypeptide binding]; other site
999541006748	OsmC-like protein; Region: OsmC; pfam02566
999541006749	Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413
999541006750	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
999541006751	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541006752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541006753	Walker A/P-loop; other site
999541006754	ATP binding site [chemical binding]; other site
999541006755	Q-loop/lid; other site
999541006756	ABC transporter signature motif; other site
999541006757	Walker B; other site
999541006758	D-loop; other site
999541006759	H-loop/switch region; other site
999541006760	CAAX protease self-immunity; Region: Abi; pfam02517
999541006761	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
999541006762	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
999541006763	Cl- selectivity filter; other site
999541006764	Cl- binding residues [ion binding]; other site
999541006765	pore gating glutamate residue; other site
999541006766	dimer interface [polypeptide binding]; other site
999541006767	CsbD-like; Region: CsbD; pfam05532
999541006768	PAS domain; Region: PAS_9; pfam13426
999541006769	PAS domain S-box; Region: sensory_box; TIGR00229
999541006770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541006771	putative active site [active]
999541006772	heme pocket [chemical binding]; other site
999541006773	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541006774	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541006775	DNA binding residues [nucleotide binding]
999541006776	dimerization interface [polypeptide binding]; other site
999541006777	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
999541006778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006779	phosphorylation site [posttranslational modification]
999541006780	intermolecular recognition site; other site
999541006781	CheB methylesterase; Region: CheB_methylest; pfam01339
999541006782	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
999541006783	putative binding surface; other site
999541006784	active site
999541006785	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
999541006786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006787	ATP binding site [chemical binding]; other site
999541006788	Mg2+ binding site [ion binding]; other site
999541006789	G-X-G motif; other site
999541006790	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
999541006791	Response regulator receiver domain; Region: Response_reg; pfam00072
999541006792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006793	active site
999541006794	phosphorylation site [posttranslational modification]
999541006795	intermolecular recognition site; other site
999541006796	dimerization interface [polypeptide binding]; other site
999541006797	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
999541006798	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
999541006799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541006800	TPR motif; other site
999541006801	binding surface
999541006802	CheW-like domain; Region: CheW; pfam01584
999541006803	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541006804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541006805	dimerization interface [polypeptide binding]; other site
999541006806	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541006807	dimer interface [polypeptide binding]; other site
999541006808	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
999541006809	putative CheW interface [polypeptide binding]; other site
999541006810	Response regulator receiver domain; Region: Response_reg; pfam00072
999541006811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006812	active site
999541006813	phosphorylation site [posttranslational modification]
999541006814	intermolecular recognition site; other site
999541006815	dimerization interface [polypeptide binding]; other site
999541006816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
999541006817	dimer interface [polypeptide binding]; other site
999541006818	phosphorylation site [posttranslational modification]
999541006819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006820	ATP binding site [chemical binding]; other site
999541006821	Mg2+ binding site [ion binding]; other site
999541006822	G-X-G motif; other site
999541006823	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
999541006824	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541006825	NAD(P) binding site [chemical binding]; other site
999541006826	catalytic residues [active]
999541006827	acetolactate synthase; Reviewed; Region: PRK08322
999541006828	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541006829	PYR/PP interface [polypeptide binding]; other site
999541006830	dimer interface [polypeptide binding]; other site
999541006831	TPP binding site [chemical binding]; other site
999541006832	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541006833	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
999541006834	TPP-binding site [chemical binding]; other site
999541006835	dimer interface [polypeptide binding]; other site
999541006836	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
999541006837	Protein of unknown function (DUF445); Region: DUF445; pfam04286
999541006838	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
999541006839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541006840	Coenzyme A binding pocket [chemical binding]; other site
999541006841	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
999541006842	putative active site [active]
999541006843	catalytic site [active]
999541006844	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
999541006845	PLD-like domain; Region: PLDc_2; pfam13091
999541006846	putative active site [active]
999541006847	catalytic site [active]
999541006848	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
999541006849	HIT family signature motif; other site
999541006850	catalytic residue [active]
999541006851	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
999541006852	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541006853	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
999541006854	[2Fe-2S] cluster binding site [ion binding]; other site
999541006855	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
999541006856	inter-subunit interface; other site
999541006857	Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545
999541006858	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
999541006859	putative alpha subunit interface [polypeptide binding]; other site
999541006860	putative active site [active]
999541006861	putative substrate binding site [chemical binding]; other site
999541006862	Fe binding site [ion binding]; other site
999541006863	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541006864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541006865	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006866	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006867	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541006868	dimerization interface [polypeptide binding]; other site
999541006869	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
999541006870	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
999541006871	octamer interface [polypeptide binding]; other site
999541006872	active site
999541006873	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
999541006874	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
999541006875	active site
999541006876	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
999541006877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541006878	dimer interface [polypeptide binding]; other site
999541006879	phosphorylation site [posttranslational modification]
999541006880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541006881	ATP binding site [chemical binding]; other site
999541006882	Mg2+ binding site [ion binding]; other site
999541006883	G-X-G motif; other site
999541006884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541006885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541006886	active site
999541006887	phosphorylation site [posttranslational modification]
999541006888	intermolecular recognition site; other site
999541006889	dimerization interface [polypeptide binding]; other site
999541006890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541006891	DNA binding site [nucleotide binding]
999541006892	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
999541006893	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
999541006894	Subunit I/III interface [polypeptide binding]; other site
999541006895	Subunit III/IV interface [polypeptide binding]; other site
999541006896	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
999541006897	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
999541006898	D-pathway; other site
999541006899	Putative ubiquinol binding site [chemical binding]; other site
999541006900	Low-spin heme (heme b) binding site [chemical binding]; other site
999541006901	Putative water exit pathway; other site
999541006902	Binuclear center (heme o3/CuB) [ion binding]; other site
999541006903	K-pathway; other site
999541006904	Putative proton exit pathway; other site
999541006905	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
999541006906	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
999541006907	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
999541006908	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
999541006909	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
999541006910	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541006911	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
999541006912	active site
999541006913	FMN binding site [chemical binding]; other site
999541006914	2,4-decadienoyl-CoA binding site; other site
999541006915	catalytic residue [active]
999541006916	4Fe-4S cluster binding site [ion binding]; other site
999541006917	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
999541006918	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541006919	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
999541006920	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541006921	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541006922	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
999541006923	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
999541006924	Walker A/P-loop; other site
999541006925	ATP binding site [chemical binding]; other site
999541006926	Q-loop/lid; other site
999541006927	ABC transporter signature motif; other site
999541006928	Walker B; other site
999541006929	D-loop; other site
999541006930	H-loop/switch region; other site
999541006931	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
999541006932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006933	dimer interface [polypeptide binding]; other site
999541006934	conserved gate region; other site
999541006935	putative PBP binding loops; other site
999541006936	ABC-ATPase subunit interface; other site
999541006937	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541006938	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
999541006939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541006940	dimer interface [polypeptide binding]; other site
999541006941	conserved gate region; other site
999541006942	putative PBP binding loops; other site
999541006943	ABC-ATPase subunit interface; other site
999541006944	lysine transporter; Provisional; Region: PRK10836
999541006945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
999541006946	YheO-like PAS domain; Region: PAS_6; pfam08348
999541006947	HTH domain; Region: HTH_22; pfam13309
999541006948	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541006949	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
999541006950	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541006951	ligand binding site [chemical binding]; other site
999541006952	flexible hinge region; other site
999541006953	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541006954	putative switch regulator; other site
999541006955	non-specific DNA interactions [nucleotide binding]; other site
999541006956	DNA binding site [nucleotide binding]
999541006957	sequence specific DNA binding site [nucleotide binding]; other site
999541006958	putative cAMP binding site [chemical binding]; other site
999541006959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541006960	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
999541006961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541006962	NAD(P) binding site [chemical binding]; other site
999541006963	active site
999541006964	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
999541006965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
999541006966	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541006967	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
999541006968	nucleophilic elbow; other site
999541006969	catalytic triad; other site
999541006970	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
999541006971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541006972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541006973	homodimer interface [polypeptide binding]; other site
999541006974	catalytic residue [active]
999541006975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541006976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541006977	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541006978	dimerization interface [polypeptide binding]; other site
999541006979	Cache domain; Region: Cache_1; pfam02743
999541006980	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541006981	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541006982	metal binding site [ion binding]; metal-binding site
999541006983	active site
999541006984	I-site; other site
999541006985	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
999541006986	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
999541006987	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
999541006988	active site
999541006989	homotetramer interface [polypeptide binding]; other site
999541006990	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
999541006991	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
999541006992	[4Fe-4S] binding site [ion binding]; other site
999541006993	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541006994	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541006995	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
999541006996	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
999541006997	molybdopterin cofactor binding site; other site
999541006998	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
999541006999	4Fe-4S binding domain; Region: Fer4; cl02805
999541007000	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
999541007001	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
999541007002	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
999541007003	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
999541007004	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
999541007005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007006	putative substrate translocation pore; other site
999541007007	Predicted membrane protein [Function unknown]; Region: COG2259
999541007008	Pirin-related protein [General function prediction only]; Region: COG1741
999541007009	Pirin; Region: Pirin; pfam02678
999541007010	LysR family transcriptional regulator; Provisional; Region: PRK14997
999541007011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007012	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541007013	putative effector binding pocket; other site
999541007014	dimerization interface [polypeptide binding]; other site
999541007015	enterobactin exporter EntS; Provisional; Region: PRK10489
999541007016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007018	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
999541007019	putative dimerization interface [polypeptide binding]; other site
999541007020	Predicted permeases [General function prediction only]; Region: COG0679
999541007021	Flavin Reductases; Region: FlaRed; cl00801
999541007022	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
999541007023	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007024	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007025	dimerization interface [polypeptide binding]; other site
999541007026	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
999541007027	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
999541007028	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541007029	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541007030	DNA-binding site [nucleotide binding]; DNA binding site
999541007031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541007032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007033	homodimer interface [polypeptide binding]; other site
999541007034	catalytic residue [active]
999541007035	short chain dehydrogenase; Provisional; Region: PRK06482
999541007036	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541007037	NADP binding site [chemical binding]; other site
999541007038	active site
999541007039	steroid binding site; other site
999541007040	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007042	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541007043	putative effector binding pocket; other site
999541007044	putative dimerization interface [polypeptide binding]; other site
999541007045	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
999541007046	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541007047	Serine hydrolase; Region: Ser_hydrolase; cl17834
999541007048	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
999541007049	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
999541007050	active site
999541007051	catalytic triad [active]
999541007052	dimer interface [polypeptide binding]; other site
999541007053	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
999541007054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007055	NAD(P) binding site [chemical binding]; other site
999541007056	active site
999541007057	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
999541007058	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
999541007059	Rubredoxin; Region: Rubredoxin; pfam00301
999541007060	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
999541007061	iron binding site [ion binding]; other site
999541007062	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541007063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541007064	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
999541007065	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
999541007066	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
999541007067	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
999541007068	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
999541007069	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
999541007070	active site
999541007071	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
999541007072	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541007073	active site
999541007074	nucleotide binding site [chemical binding]; other site
999541007075	HIGH motif; other site
999541007076	KMSKS motif; other site
999541007077	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
999541007078	nudix motif; other site
999541007079	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
999541007080	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
999541007081	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
999541007082	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
999541007083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
999541007084	alanine racemase; Reviewed; Region: dadX; PRK03646
999541007085	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
999541007086	active site
999541007087	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541007088	substrate binding site [chemical binding]; other site
999541007089	catalytic residues [active]
999541007090	dimer interface [polypeptide binding]; other site
999541007091	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541007092	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541007093	trimer interface [polypeptide binding]; other site
999541007094	eyelet of channel; other site
999541007095	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
999541007096	active site residue [active]
999541007097	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
999541007098	active site residue [active]
999541007099	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
999541007100	active site residue [active]
999541007101	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
999541007102	active site residue [active]
999541007103	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
999541007104	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541007107	dimerization interface [polypeptide binding]; other site
999541007108	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541007109	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
999541007110	active site
999541007111	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
999541007112	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
999541007113	dimer interface [polypeptide binding]; other site
999541007114	active site
999541007115	non-prolyl cis peptide bond; other site
999541007116	insertion regions; other site
999541007117	hypothetical protein; Provisional; Region: PRK06208
999541007118	intersubunit interface [polypeptide binding]; other site
999541007119	active site
999541007120	Zn2+ binding site [ion binding]; other site
999541007121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
999541007122	NMT1/THI5 like; Region: NMT1; pfam09084
999541007123	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541007124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007125	dimer interface [polypeptide binding]; other site
999541007126	conserved gate region; other site
999541007127	putative PBP binding loops; other site
999541007128	ABC-ATPase subunit interface; other site
999541007129	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541007130	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541007131	Walker A/P-loop; other site
999541007132	ATP binding site [chemical binding]; other site
999541007133	Q-loop/lid; other site
999541007134	ABC transporter signature motif; other site
999541007135	Walker B; other site
999541007136	D-loop; other site
999541007137	H-loop/switch region; other site
999541007138	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541007139	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541007140	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541007141	membrane-bound complex binding site; other site
999541007142	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
999541007143	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
999541007144	MOSC domain; Region: MOSC; pfam03473
999541007145	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
999541007146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541007147	dimer interface [polypeptide binding]; other site
999541007148	phosphorylation site [posttranslational modification]
999541007149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007150	ATP binding site [chemical binding]; other site
999541007151	Mg2+ binding site [ion binding]; other site
999541007152	G-X-G motif; other site
999541007153	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
999541007154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007155	active site
999541007156	phosphorylation site [posttranslational modification]
999541007157	intermolecular recognition site; other site
999541007158	dimerization interface [polypeptide binding]; other site
999541007159	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541007160	DNA binding site [nucleotide binding]
999541007161	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541007162	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541007163	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
999541007164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007165	dimer interface [polypeptide binding]; other site
999541007166	conserved gate region; other site
999541007167	ABC-ATPase subunit interface; other site
999541007168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007169	dimer interface [polypeptide binding]; other site
999541007170	conserved gate region; other site
999541007171	putative PBP binding loops; other site
999541007172	ABC-ATPase subunit interface; other site
999541007173	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541007174	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
999541007175	Walker A/P-loop; other site
999541007176	ATP binding site [chemical binding]; other site
999541007177	Q-loop/lid; other site
999541007178	ABC transporter signature motif; other site
999541007179	Walker B; other site
999541007180	D-loop; other site
999541007181	H-loop/switch region; other site
999541007182	TOBE domain; Region: TOBE_2; pfam08402
999541007183	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541007184	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541007185	trimer interface [polypeptide binding]; other site
999541007186	eyelet of channel; other site
999541007187	MarR family; Region: MarR_2; cl17246
999541007188	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541007189	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
999541007190	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541007191	active site
999541007192	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
999541007193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541007194	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541007195	DNA binding site [nucleotide binding]
999541007196	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
999541007197	Trehalase; Region: Trehalase; cl17346
999541007198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541007199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541007200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007201	putative transporter; Provisional; Region: PRK10504
999541007202	putative substrate translocation pore; other site
999541007203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
999541007204	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
999541007205	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
999541007206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541007207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541007208	Coenzyme A binding pocket [chemical binding]; other site
999541007209	hypothetical protein; Provisional; Region: PRK07907
999541007210	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
999541007211	metal binding site [ion binding]; metal-binding site
999541007212	putative dimer interface [polypeptide binding]; other site
999541007213	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
999541007214	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541007215	conserved cys residue [active]
999541007216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541007217	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
999541007218	active site residue [active]
999541007219	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
999541007220	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
999541007221	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541007222	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541007223	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541007224	putative active site [active]
999541007225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541007226	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
999541007227	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
999541007228	putative dimer interface [polypeptide binding]; other site
999541007229	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
999541007230	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
999541007231	rod shape-determining protein MreB; Provisional; Region: PRK13930
999541007232	MreB and similar proteins; Region: MreB_like; cd10225
999541007233	nucleotide binding site [chemical binding]; other site
999541007234	Mg binding site [ion binding]; other site
999541007235	putative protofilament interaction site [polypeptide binding]; other site
999541007236	RodZ interaction site [polypeptide binding]; other site
999541007237	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541007238	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
999541007239	active site
999541007240	nucleophile elbow; other site
999541007241	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007242	Surface antigen; Region: Bac_surface_Ag; pfam01103
999541007243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541007244	dimer interface [polypeptide binding]; other site
999541007245	phosphorylation site [posttranslational modification]
999541007246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007247	ATP binding site [chemical binding]; other site
999541007248	Mg2+ binding site [ion binding]; other site
999541007249	G-X-G motif; other site
999541007250	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
999541007251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007252	active site
999541007253	phosphorylation site [posttranslational modification]
999541007254	intermolecular recognition site; other site
999541007255	dimerization interface [polypeptide binding]; other site
999541007256	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541007257	DNA binding site [nucleotide binding]
999541007258	Secretin and TonB N terminus short domain; Region: STN; smart00965
999541007259	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
999541007260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541007261	N-terminal plug; other site
999541007262	ligand-binding site [chemical binding]; other site
999541007263	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
999541007264	glutaminase; Provisional; Region: PRK00971
999541007265	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
999541007266	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
999541007267	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541007268	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541007269	trimer interface [polypeptide binding]; other site
999541007270	eyelet of channel; other site
999541007271	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
999541007272	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
999541007273	Walker A/P-loop; other site
999541007274	ATP binding site [chemical binding]; other site
999541007275	Q-loop/lid; other site
999541007276	ABC transporter signature motif; other site
999541007277	Walker B; other site
999541007278	D-loop; other site
999541007279	H-loop/switch region; other site
999541007280	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541007281	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541007282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541007283	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541007284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007285	dimer interface [polypeptide binding]; other site
999541007286	conserved gate region; other site
999541007287	putative PBP binding loops; other site
999541007288	ABC-ATPase subunit interface; other site
999541007289	putative glutathione S-transferase; Provisional; Region: PRK10357
999541007290	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541007291	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541007292	substrate binding pocket (H-site) [chemical binding]; other site
999541007293	N-terminal domain interface [polypeptide binding]; other site
999541007294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
999541007295	ACT domain; Region: ACT_3; pfam10000
999541007296	Family description; Region: ACT_7; pfam13840
999541007297	transcriptional regulator; Provisional; Region: PRK10632
999541007298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007299	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
999541007300	putative effector binding pocket; other site
999541007301	putative dimerization interface [polypeptide binding]; other site
999541007302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541007303	putative DNA binding site [nucleotide binding]; other site
999541007304	dimerization interface [polypeptide binding]; other site
999541007305	putative Zn2+ binding site [ion binding]; other site
999541007306	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
999541007307	Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857
999541007308	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541007309	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541007310	trimer interface [polypeptide binding]; other site
999541007311	eyelet of channel; other site
999541007312	Predicted transcriptional regulators [Transcription]; Region: COG1510
999541007313	MarR family; Region: MarR_2; pfam12802
999541007314	proline/glycine betaine transporter; Provisional; Region: PRK10642
999541007315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007316	putative substrate translocation pore; other site
999541007317	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541007318	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541007319	conserved cys residue [active]
999541007320	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541007321	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541007322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007323	NAD(P) binding site [chemical binding]; other site
999541007324	active site
999541007325	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541007326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541007327	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541007328	short chain dehydrogenase; Provisional; Region: PRK07023
999541007329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007330	NAD(P) binding site [chemical binding]; other site
999541007331	active site
999541007332	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541007333	inhibitor site; inhibition site
999541007334	active site
999541007335	dimer interface [polypeptide binding]; other site
999541007336	catalytic residue [active]
999541007337	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541007338	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541007339	DNA-binding site [nucleotide binding]; DNA binding site
999541007340	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541007341	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
999541007342	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
999541007343	dimer interface [polypeptide binding]; other site
999541007344	NADP binding site [chemical binding]; other site
999541007345	catalytic residues [active]
999541007346	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
999541007347	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541007348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007349	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007350	dimerization interface [polypeptide binding]; other site
999541007351	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541007352	FAD binding domain; Region: FAD_binding_4; pfam01565
999541007353	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
999541007354	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
999541007355	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541007356	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541007357	dimer interface [polypeptide binding]; other site
999541007358	putative CheW interface [polypeptide binding]; other site
999541007359	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541007360	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541007361	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
999541007362	Isochorismatase family; Region: Isochorismatase; pfam00857
999541007363	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
999541007364	catalytic triad [active]
999541007365	conserved cis-peptide bond; other site
999541007366	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541007367	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541007368	metal binding site [ion binding]; metal-binding site
999541007369	putative dimer interface [polypeptide binding]; other site
999541007370	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
999541007371	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541007372	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541007373	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541007374	putative DNA binding site [nucleotide binding]; other site
999541007375	putative Zn2+ binding site [ion binding]; other site
999541007376	AsnC family; Region: AsnC_trans_reg; pfam01037
999541007377	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
999541007378	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541007379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541007380	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541007381	MarR family; Region: MarR_2; pfam12802
999541007382	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
999541007383	amphipathic channel; other site
999541007384	Asn-Pro-Ala signature motifs; other site
999541007385	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
999541007386	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541007387	inhibitor-cofactor binding pocket; inhibition site
999541007388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007389	catalytic residue [active]
999541007390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007392	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
999541007393	putative dimerization interface [polypeptide binding]; other site
999541007394	EamA-like transporter family; Region: EamA; pfam00892
999541007395	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
999541007396	EamA-like transporter family; Region: EamA; pfam00892
999541007397	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541007398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007400	dimerization interface [polypeptide binding]; other site
999541007401	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
999541007402	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
999541007403	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
999541007404	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541007405	substrate binding pocket [chemical binding]; other site
999541007406	membrane-bound complex binding site; other site
999541007407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541007408	DNA-binding site [nucleotide binding]; DNA binding site
999541007409	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541007410	FCD domain; Region: FCD; pfam07729
999541007411	aconitate hydratase; Provisional; Region: acnA; PRK12881
999541007412	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
999541007413	substrate binding site [chemical binding]; other site
999541007414	ligand binding site [chemical binding]; other site
999541007415	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
999541007416	substrate binding site [chemical binding]; other site
999541007417	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
999541007418	alpha-galactosidase; Region: PLN02808; cl17638
999541007419	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
999541007420	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
999541007421	Ca binding site [ion binding]; other site
999541007422	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
999541007423	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541007424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541007425	DNA-binding site [nucleotide binding]; DNA binding site
999541007426	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541007427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007428	homodimer interface [polypeptide binding]; other site
999541007429	catalytic residue [active]
999541007430	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541007431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007432	active site
999541007433	phosphorylation site [posttranslational modification]
999541007434	intermolecular recognition site; other site
999541007435	dimerization interface [polypeptide binding]; other site
999541007436	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541007437	DNA binding residues [nucleotide binding]
999541007438	dimerization interface [polypeptide binding]; other site
999541007439	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
999541007440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
999541007441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007442	Mg2+ binding site [ion binding]; other site
999541007443	G-X-G motif; other site
999541007444	RNA polymerase sigma factor; Provisional; Region: PRK12536
999541007445	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541007446	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541007447	DNA binding residues [nucleotide binding]
999541007448	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
999541007449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007450	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541007451	putative substrate translocation pore; other site
999541007452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007454	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541007455	putative effector binding pocket; other site
999541007456	dimerization interface [polypeptide binding]; other site
999541007457	Malonate transporter MadL subunit; Region: MadL; cl04273
999541007458	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
999541007459	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541007460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541007461	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
999541007462	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541007463	Sel1-like repeats; Region: SEL1; smart00671
999541007464	putative transporter; Provisional; Region: PRK10504
999541007465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007466	putative substrate translocation pore; other site
999541007467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007468	acetylornithine deacetylase; Provisional; Region: PRK07522
999541007469	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
999541007470	metal binding site [ion binding]; metal-binding site
999541007471	putative dimer interface [polypeptide binding]; other site
999541007472	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541007473	homotrimer interaction site [polypeptide binding]; other site
999541007474	putative active site [active]
999541007475	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541007476	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541007477	Walker A/P-loop; other site
999541007478	ATP binding site [chemical binding]; other site
999541007479	Q-loop/lid; other site
999541007480	ABC transporter signature motif; other site
999541007481	Walker B; other site
999541007482	D-loop; other site
999541007483	H-loop/switch region; other site
999541007484	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
999541007485	agmatinase; Region: agmatinase; TIGR01230
999541007486	oligomer interface [polypeptide binding]; other site
999541007487	active site
999541007488	Mn binding site [ion binding]; other site
999541007489	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541007490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007491	dimer interface [polypeptide binding]; other site
999541007492	conserved gate region; other site
999541007493	putative PBP binding loops; other site
999541007494	ABC-ATPase subunit interface; other site
999541007495	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541007496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007497	dimer interface [polypeptide binding]; other site
999541007498	conserved gate region; other site
999541007499	putative PBP binding loops; other site
999541007500	ABC-ATPase subunit interface; other site
999541007501	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541007502	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541007503	substrate binding pocket [chemical binding]; other site
999541007504	membrane-bound complex binding site; other site
999541007505	hinge residues; other site
999541007506	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007507	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007508	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541007509	dimerization interface [polypeptide binding]; other site
999541007510	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
999541007511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541007512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541007513	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
999541007514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541007515	motif II; other site
999541007516	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541007517	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
999541007518	catalytic site [active]
999541007519	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541007520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007521	active site
999541007522	phosphorylation site [posttranslational modification]
999541007523	intermolecular recognition site; other site
999541007524	dimerization interface [polypeptide binding]; other site
999541007525	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541007526	DNA binding site [nucleotide binding]
999541007527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541007528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007529	ATP binding site [chemical binding]; other site
999541007530	Mg2+ binding site [ion binding]; other site
999541007531	G-X-G motif; other site
999541007532	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
999541007533	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
999541007534	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
999541007535	transcriptional regulator; Provisional; Region: PRK10632
999541007536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007537	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541007538	putative effector binding pocket; other site
999541007539	dimerization interface [polypeptide binding]; other site
999541007540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007541	short chain dehydrogenase; Provisional; Region: PRK06197
999541007542	NAD(P) binding site [chemical binding]; other site
999541007543	active site
999541007544	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541007545	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
999541007546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007547	NAD(P) binding site [chemical binding]; other site
999541007548	active site
999541007549	MASE1; Region: MASE1; cl17823
999541007550	PAS fold; Region: PAS_3; pfam08447
999541007551	Esterase/lipase [General function prediction only]; Region: COG1647
999541007552	maleylacetoacetate isomerase; Region: maiA; TIGR01262
999541007553	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
999541007554	C-terminal domain interface [polypeptide binding]; other site
999541007555	GSH binding site (G-site) [chemical binding]; other site
999541007556	putative dimer interface [polypeptide binding]; other site
999541007557	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
999541007558	dimer interface [polypeptide binding]; other site
999541007559	N-terminal domain interface [polypeptide binding]; other site
999541007560	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
999541007561	fumarylacetoacetase; Region: PLN02856
999541007562	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
999541007563	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541007564	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
999541007565	Flagellin N-methylase; Region: FliB; pfam03692
999541007566	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
999541007567	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
999541007568	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541007569	GAF domain; Region: GAF; pfam01590
999541007570	Phytochrome region; Region: PHY; pfam00360
999541007571	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541007572	dimer interface [polypeptide binding]; other site
999541007573	phosphorylation site [posttranslational modification]
999541007574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007575	ATP binding site [chemical binding]; other site
999541007576	Mg2+ binding site [ion binding]; other site
999541007577	G-X-G motif; other site
999541007578	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541007579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007580	active site
999541007581	phosphorylation site [posttranslational modification]
999541007582	intermolecular recognition site; other site
999541007583	dimerization interface [polypeptide binding]; other site
999541007584	PAS domain; Region: PAS_9; pfam13426
999541007585	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541007586	PAS fold; Region: PAS_3; pfam08447
999541007587	putative active site [active]
999541007588	heme pocket [chemical binding]; other site
999541007589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541007590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541007591	dimer interface [polypeptide binding]; other site
999541007592	phosphorylation site [posttranslational modification]
999541007593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541007594	ATP binding site [chemical binding]; other site
999541007595	Mg2+ binding site [ion binding]; other site
999541007596	G-X-G motif; other site
999541007597	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
999541007598	heme binding pocket [chemical binding]; other site
999541007599	Response regulator receiver domain; Region: Response_reg; pfam00072
999541007600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007601	active site
999541007602	phosphorylation site [posttranslational modification]
999541007603	intermolecular recognition site; other site
999541007604	dimerization interface [polypeptide binding]; other site
999541007605	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
999541007606	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541007607	Walker A motif; other site
999541007608	ATP binding site [chemical binding]; other site
999541007609	Walker B motif; other site
999541007610	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541007611	Walker A motif; other site
999541007612	ATP binding site [chemical binding]; other site
999541007613	Walker B motif; other site
999541007614	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541007615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541007616	short chain dehydrogenase; Validated; Region: PRK08264
999541007617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007618	NAD(P) binding site [chemical binding]; other site
999541007619	active site
999541007620	ferric uptake regulator; Provisional; Region: fur; PRK09462
999541007621	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
999541007622	metal binding site 2 [ion binding]; metal-binding site
999541007623	putative DNA binding helix; other site
999541007624	metal binding site 1 [ion binding]; metal-binding site
999541007625	dimer interface [polypeptide binding]; other site
999541007626	structural Zn2+ binding site [ion binding]; other site
999541007627	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
999541007628	gating phenylalanine in ion channel; other site
999541007629	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541007630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541007631	active site
999541007632	phosphorylation site [posttranslational modification]
999541007633	intermolecular recognition site; other site
999541007634	dimerization interface [polypeptide binding]; other site
999541007635	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541007636	DNA binding site [nucleotide binding]
999541007637	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541007638	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541007639	trimer interface [polypeptide binding]; other site
999541007640	eyelet of channel; other site
999541007641	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
999541007642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541007643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007644	homodimer interface [polypeptide binding]; other site
999541007645	catalytic residue [active]
999541007646	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541007647	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
999541007648	aldehyde dehydrogenase family 7 member; Region: PLN02315
999541007649	tetrameric interface [polypeptide binding]; other site
999541007650	NAD binding site [chemical binding]; other site
999541007651	catalytic residues [active]
999541007652	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541007653	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541007654	dimerization interface [polypeptide binding]; other site
999541007655	ligand binding site [chemical binding]; other site
999541007656	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
999541007657	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541007658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007659	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007660	dimerization interface [polypeptide binding]; other site
999541007661	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541007662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
999541007663	Coenzyme A binding pocket [chemical binding]; other site
999541007664	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
999541007665	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541007666	dimerization interface [polypeptide binding]; other site
999541007667	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541007668	dimer interface [polypeptide binding]; other site
999541007669	putative CheW interface [polypeptide binding]; other site
999541007670	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
999541007671	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541007672	catalytic loop [active]
999541007673	iron binding site [ion binding]; other site
999541007674	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
999541007675	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
999541007676	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
999541007677	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
999541007678	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
999541007679	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541007680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007682	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541007683	putative effector binding pocket; other site
999541007684	dimerization interface [polypeptide binding]; other site
999541007685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007686	NmrA-like family; Region: NmrA; pfam05368
999541007687	NAD(P) binding site [chemical binding]; other site
999541007688	active site
999541007689	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541007690	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
999541007691	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
999541007692	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
999541007693	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
999541007694	Secretory lipase; Region: LIP; pfam03583
999541007695	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
999541007696	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
999541007697	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541007698	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541007699	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
999541007700	active site
999541007701	FMN binding site [chemical binding]; other site
999541007702	substrate binding site [chemical binding]; other site
999541007703	homotetramer interface [polypeptide binding]; other site
999541007704	catalytic residue [active]
999541007705	Uncharacterized conserved protein [Function unknown]; Region: COG2128
999541007706	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
999541007707	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
999541007708	putative catalytic residues [active]
999541007709	short chain dehydrogenase; Provisional; Region: PRK07577
999541007710	classical (c) SDRs; Region: SDR_c; cd05233
999541007711	NAD(P) binding site [chemical binding]; other site
999541007712	active site
999541007713	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007715	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541007716	putative effector binding pocket; other site
999541007717	dimerization interface [polypeptide binding]; other site
999541007718	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541007719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007720	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541007721	dimerization interface [polypeptide binding]; other site
999541007722	substrate binding pocket [chemical binding]; other site
999541007723	EamA-like transporter family; Region: EamA; pfam00892
999541007724	EamA-like transporter family; Region: EamA; pfam00892
999541007725	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
999541007726	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
999541007727	tetramer interface [polypeptide binding]; other site
999541007728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007729	catalytic residue [active]
999541007730	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
999541007731	putative active site [active]
999541007732	Zn binding site [ion binding]; other site
999541007733	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
999541007734	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
999541007735	heme binding pocket [chemical binding]; other site
999541007736	heme ligand [chemical binding]; other site
999541007737	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541007738	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
999541007739	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
999541007740	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541007741	extended (e) SDRs; Region: SDR_e; cd08946
999541007742	NAD(P) binding site [chemical binding]; other site
999541007743	active site
999541007744	substrate binding site [chemical binding]; other site
999541007745	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541007746	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541007747	TM-ABC transporter signature motif; other site
999541007748	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541007749	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541007750	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541007751	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541007752	Walker A/P-loop; other site
999541007753	ATP binding site [chemical binding]; other site
999541007754	Q-loop/lid; other site
999541007755	ABC transporter signature motif; other site
999541007756	Walker B; other site
999541007757	D-loop; other site
999541007758	H-loop/switch region; other site
999541007759	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541007760	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
999541007761	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541007762	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
999541007763	ligand binding site [chemical binding]; other site
999541007764	flexible hinge region; other site
999541007765	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541007766	non-specific DNA interactions [nucleotide binding]; other site
999541007767	DNA binding site [nucleotide binding]
999541007768	sequence specific DNA binding site [nucleotide binding]; other site
999541007769	putative cAMP binding site [chemical binding]; other site
999541007770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007773	dimerization interface [polypeptide binding]; other site
999541007774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007775	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541007776	NAD(P) binding site [chemical binding]; other site
999541007777	active site
999541007778	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541007779	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541007780	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
999541007781	Peptidase family M28; Region: Peptidase_M28; pfam04389
999541007782	active site
999541007783	metal binding site [ion binding]; metal-binding site
999541007784	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
999541007785	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
999541007786	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
999541007787	Zn binding site [ion binding]; other site
999541007788	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007790	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
999541007791	putative dimerization interface [polypeptide binding]; other site
999541007792	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541007793	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
999541007794	putative ligand binding site [chemical binding]; other site
999541007795	NAD binding site [chemical binding]; other site
999541007796	catalytic site [active]
999541007797	dihydroxy-acid dehydratase; Validated; Region: PRK06131
999541007798	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541007799	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541007800	inhibitor site; inhibition site
999541007801	active site
999541007802	dimer interface [polypeptide binding]; other site
999541007803	catalytic residue [active]
999541007804	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541007805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007806	putative substrate translocation pore; other site
999541007807	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
999541007808	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541007809	motif II; other site
999541007810	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
999541007811	MEKHLA domain; Region: MEKHLA; pfam08670
999541007812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541007813	putative active site [active]
999541007814	heme pocket [chemical binding]; other site
999541007815	MarR family; Region: MarR_2; cl17246
999541007816	Predicted transcriptional regulator [Transcription]; Region: COG2345
999541007817	Transcriptional regulator PadR-like family; Region: PadR; cl17335
999541007818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007819	putative substrate translocation pore; other site
999541007820	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
999541007821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541007822	S-adenosylmethionine binding site [chemical binding]; other site
999541007823	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541007824	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541007825	CsbD-like; Region: CsbD; pfam05532
999541007826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541007827	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
999541007828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541007829	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
999541007830	putative active site [active]
999541007831	heme pocket [chemical binding]; other site
999541007832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541007833	putative active site [active]
999541007834	heme pocket [chemical binding]; other site
999541007835	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541007836	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541007837	DNA binding residues [nucleotide binding]
999541007838	dimerization interface [polypeptide binding]; other site
999541007839	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
999541007840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007842	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
999541007843	putative substrate binding pocket [chemical binding]; other site
999541007844	dimerization interface [polypeptide binding]; other site
999541007845	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541007846	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
999541007847	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
999541007848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541007849	short chain dehydrogenase; Provisional; Region: PRK08219
999541007850	NAD(P) binding site [chemical binding]; other site
999541007851	active site
999541007852	acetylornithine deacetylase; Provisional; Region: PRK07522
999541007853	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
999541007854	metal binding site [ion binding]; metal-binding site
999541007855	putative dimer interface [polypeptide binding]; other site
999541007856	Uncharacterized conserved protein [Function unknown]; Region: COG3342
999541007857	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
999541007858	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541007859	homotrimer interaction site [polypeptide binding]; other site
999541007860	putative active site [active]
999541007861	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541007862	homotrimer interaction site [polypeptide binding]; other site
999541007863	putative active site [active]
999541007864	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
999541007865	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541007866	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541007867	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541007868	metal binding site [ion binding]; metal-binding site
999541007869	putative dimer interface [polypeptide binding]; other site
999541007870	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
999541007871	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541007872	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541007873	NAD(P) binding site [chemical binding]; other site
999541007874	catalytic residues [active]
999541007875	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541007876	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541007877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007879	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007880	dimerization interface [polypeptide binding]; other site
999541007881	hypothetical protein; Provisional; Region: PRK11239
999541007882	Protein of unknown function, DUF480; Region: DUF480; pfam04337
999541007883	Homeobox associated leucine zipper; Region: HALZ; cl02577
999541007884	benzoate transport; Region: 2A0115; TIGR00895
999541007885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007886	putative substrate translocation pore; other site
999541007887	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541007888	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541007889	N-terminal plug; other site
999541007890	ligand-binding site [chemical binding]; other site
999541007891	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
999541007892	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
999541007893	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541007894	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541007895	Walker A/P-loop; other site
999541007896	ATP binding site [chemical binding]; other site
999541007897	Q-loop/lid; other site
999541007898	ABC transporter signature motif; other site
999541007899	Walker B; other site
999541007900	D-loop; other site
999541007901	H-loop/switch region; other site
999541007902	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541007903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541007904	dimer interface [polypeptide binding]; other site
999541007905	conserved gate region; other site
999541007906	putative PBP binding loops; other site
999541007907	ABC-ATPase subunit interface; other site
999541007908	urea carboxylase; Region: urea_carbox; TIGR02712
999541007909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541007910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541007911	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
999541007912	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
999541007913	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
999541007914	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
999541007915	carboxyltransferase (CT) interaction site; other site
999541007916	biotinylation site [posttranslational modification]; other site
999541007917	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
999541007918	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
999541007919	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
999541007920	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
999541007921	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
999541007922	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541007923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007924	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541007925	dimerization interface [polypeptide binding]; other site
999541007926	substrate binding pocket [chemical binding]; other site
999541007927	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
999541007928	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541007929	putative di-iron ligands [ion binding]; other site
999541007930	EamA-like transporter family; Region: EamA; pfam00892
999541007931	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
999541007932	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541007933	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
999541007934	active site
999541007935	benzoate transport; Region: 2A0115; TIGR00895
999541007936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541007937	putative substrate translocation pore; other site
999541007938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007940	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541007941	dimerization interface [polypeptide binding]; other site
999541007942	substrate binding pocket [chemical binding]; other site
999541007943	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541007944	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
999541007945	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
999541007946	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007947	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007948	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007949	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007950	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541007951	Surface antigen; Region: Bac_surface_Ag; pfam01103
999541007952	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541007953	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
999541007954	classical (c) SDRs; Region: SDR_c; cd05233
999541007955	NAD(P) binding site [chemical binding]; other site
999541007956	active site
999541007957	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541007958	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541007959	metal binding site [ion binding]; metal-binding site
999541007960	active site
999541007961	I-site; other site
999541007962	Predicted transcriptional regulator [Transcription]; Region: COG1959
999541007963	Transcriptional regulator; Region: Rrf2; pfam02082
999541007964	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
999541007965	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541007966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541007967	DNA-binding site [nucleotide binding]; DNA binding site
999541007968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541007969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541007970	homodimer interface [polypeptide binding]; other site
999541007971	catalytic residue [active]
999541007972	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
999541007973	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541007974	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541007975	Coenzyme A binding pocket [chemical binding]; other site
999541007976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541007977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541007978	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541007979	dimerization interface [polypeptide binding]; other site
999541007980	Alginate lyase; Region: Alginate_lyase2; pfam08787
999541007981	RNA polymerase sigma factor; Reviewed; Region: PRK05602
999541007982	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541007983	Heavy-metal resistance; Region: Metal_resist; pfam13801
999541007984	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
999541007985	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
999541007986	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
999541007987	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
999541007988	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
999541007989	H-NS histone family; Region: Histone_HNS; pfam00816
999541007990	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541007991	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
999541007992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
999541007993	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
999541007994	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
999541007995	NAD binding site [chemical binding]; other site
999541007996	active site
999541007997	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541007998	hypothetical protein; Provisional; Region: PRK06834
999541007999	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541008000	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
999541008001	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
999541008002	peptide binding site [polypeptide binding]; other site
999541008003	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
999541008004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541008005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541008006	dimer interface [polypeptide binding]; other site
999541008007	conserved gate region; other site
999541008008	putative PBP binding loops; other site
999541008009	ABC-ATPase subunit interface; other site
999541008010	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
999541008011	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
999541008012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541008013	dimer interface [polypeptide binding]; other site
999541008014	conserved gate region; other site
999541008015	putative PBP binding loops; other site
999541008016	ABC-ATPase subunit interface; other site
999541008017	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
999541008018	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541008019	Walker A/P-loop; other site
999541008020	ATP binding site [chemical binding]; other site
999541008021	Q-loop/lid; other site
999541008022	ABC transporter signature motif; other site
999541008023	Walker B; other site
999541008024	D-loop; other site
999541008025	H-loop/switch region; other site
999541008026	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541008027	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
999541008028	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541008029	Walker A/P-loop; other site
999541008030	ATP binding site [chemical binding]; other site
999541008031	Q-loop/lid; other site
999541008032	ABC transporter signature motif; other site
999541008033	Walker B; other site
999541008034	D-loop; other site
999541008035	H-loop/switch region; other site
999541008036	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541008037	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
999541008038	active site 2 [active]
999541008039	active site 1 [active]
999541008040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541008041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541008042	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
999541008043	Coenzyme A transferase; Region: CoA_trans; smart00882
999541008044	Coenzyme A transferase; Region: CoA_trans; cl17247
999541008045	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
999541008046	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541008047	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
999541008048	shikimate binding site; other site
999541008049	NAD(P) binding site [chemical binding]; other site
999541008050	Protein of unknown function (DUF993); Region: DUF993; pfam06187
999541008051	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
999541008052	putative sialic acid transporter; Region: 2A0112; TIGR00891
999541008053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008054	putative substrate translocation pore; other site
999541008055	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541008056	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541008057	trimer interface [polypeptide binding]; other site
999541008058	eyelet of channel; other site
999541008059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008060	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541008061	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008062	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541008063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541008064	NAD(P) binding site [chemical binding]; other site
999541008065	active site
999541008066	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
999541008067	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
999541008068	active site
999541008069	Zn binding site [ion binding]; other site
999541008070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541008071	putative transposase OrfB; Reviewed; Region: PHA02517
999541008072	Integrase core domain; Region: rve; pfam00665
999541008073	Integrase core domain; Region: rve_3; pfam13683
999541008074	Transposase; Region: HTH_Tnp_1; pfam01527
999541008075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541008076	HTH-like domain; Region: HTH_21; pfam13276
999541008077	Integrase core domain; Region: rve; pfam00665
999541008078	Integrase core domain; Region: rve_3; pfam13683
999541008079	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
999541008080	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
999541008081	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541008082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008083	active site
999541008084	phosphorylation site [posttranslational modification]
999541008085	intermolecular recognition site; other site
999541008086	dimerization interface [polypeptide binding]; other site
999541008087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541008088	Walker A motif; other site
999541008089	ATP binding site [chemical binding]; other site
999541008090	Walker B motif; other site
999541008091	arginine finger; other site
999541008092	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541008093	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
999541008094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541008095	putative active site [active]
999541008096	heme pocket [chemical binding]; other site
999541008097	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541008098	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
999541008099	putative active site [active]
999541008100	heme pocket [chemical binding]; other site
999541008101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008102	dimer interface [polypeptide binding]; other site
999541008103	phosphorylation site [posttranslational modification]
999541008104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008105	ATP binding site [chemical binding]; other site
999541008106	Mg2+ binding site [ion binding]; other site
999541008107	G-X-G motif; other site
999541008108	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541008109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008110	active site
999541008111	phosphorylation site [posttranslational modification]
999541008112	intermolecular recognition site; other site
999541008113	dimerization interface [polypeptide binding]; other site
999541008114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008115	active site
999541008116	phosphorylation site [posttranslational modification]
999541008117	intermolecular recognition site; other site
999541008118	dimerization interface [polypeptide binding]; other site
999541008119	Response regulator receiver domain; Region: Response_reg; pfam00072
999541008120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008121	active site
999541008122	phosphorylation site [posttranslational modification]
999541008123	intermolecular recognition site; other site
999541008124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541008125	dimerization interface [polypeptide binding]; other site
999541008126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008127	dimer interface [polypeptide binding]; other site
999541008128	phosphorylation site [posttranslational modification]
999541008129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008130	ATP binding site [chemical binding]; other site
999541008131	Mg2+ binding site [ion binding]; other site
999541008132	G-X-G motif; other site
999541008133	CheB methylesterase; Region: CheB_methylest; pfam01339
999541008134	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
999541008135	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
999541008136	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
999541008137	CHASE3 domain; Region: CHASE3; pfam05227
999541008138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541008139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008140	dimer interface [polypeptide binding]; other site
999541008141	phosphorylation site [posttranslational modification]
999541008142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008143	ATP binding site [chemical binding]; other site
999541008144	Mg2+ binding site [ion binding]; other site
999541008145	G-X-G motif; other site
999541008146	Response regulator receiver domain; Region: Response_reg; pfam00072
999541008147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008148	active site
999541008149	phosphorylation site [posttranslational modification]
999541008150	intermolecular recognition site; other site
999541008151	dimerization interface [polypeptide binding]; other site
999541008152	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541008153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008154	active site
999541008155	phosphorylation site [posttranslational modification]
999541008156	intermolecular recognition site; other site
999541008157	dimerization interface [polypeptide binding]; other site
999541008158	Response regulator receiver domain; Region: Response_reg; pfam00072
999541008159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008160	active site
999541008161	phosphorylation site [posttranslational modification]
999541008162	intermolecular recognition site; other site
999541008163	dimerization interface [polypeptide binding]; other site
999541008164	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
999541008165	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
999541008166	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
999541008167	active site
999541008168	catalytic site [active]
999541008169	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
999541008170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541008172	dimerization interface [polypeptide binding]; other site
999541008173	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541008174	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541008175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541008177	dimerization interface [polypeptide binding]; other site
999541008178	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
999541008179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541008180	NAD(P) binding site [chemical binding]; other site
999541008181	active site
999541008182	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541008183	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
999541008184	putative C-terminal domain interface [polypeptide binding]; other site
999541008185	putative GSH binding site (G-site) [chemical binding]; other site
999541008186	putative dimer interface [polypeptide binding]; other site
999541008187	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
999541008188	putative N-terminal domain interface [polypeptide binding]; other site
999541008189	putative dimer interface [polypeptide binding]; other site
999541008190	putative substrate binding pocket (H-site) [chemical binding]; other site
999541008191	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
999541008192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008195	putative effector binding pocket; other site
999541008196	dimerization interface [polypeptide binding]; other site
999541008197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008198	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
999541008199	putative substrate translocation pore; other site
999541008200	succinic semialdehyde dehydrogenase; Region: PLN02278
999541008201	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541008202	tetramerization interface [polypeptide binding]; other site
999541008203	NAD(P) binding site [chemical binding]; other site
999541008204	catalytic residues [active]
999541008205	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541008206	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541008207	active site
999541008208	catalytic tetrad [active]
999541008209	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
999541008210	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
999541008211	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
999541008212	Catalytic site [active]
999541008213	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
999541008214	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541008215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541008216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008217	putative substrate translocation pore; other site
999541008218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008219	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
999541008220	Predicted ATPase [General function prediction only]; Region: COG3910
999541008221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541008222	Walker A/P-loop; other site
999541008223	ATP binding site [chemical binding]; other site
999541008224	Q-loop/lid; other site
999541008225	ABC transporter signature motif; other site
999541008226	Walker B; other site
999541008227	D-loop; other site
999541008228	H-loop/switch region; other site
999541008229	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
999541008230	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
999541008231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541008232	Coenzyme A binding pocket [chemical binding]; other site
999541008233	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541008234	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541008235	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008236	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008237	short chain dehydrogenase; Provisional; Region: PRK06180
999541008238	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541008239	NADP binding site [chemical binding]; other site
999541008240	active site
999541008241	steroid binding site; other site
999541008242	Cupin domain; Region: Cupin_2; pfam07883
999541008243	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
999541008244	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
999541008245	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541008246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008247	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
999541008248	putative dimerization interface [polypeptide binding]; other site
999541008249	putative substrate binding pocket [chemical binding]; other site
999541008250	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
999541008251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541008252	NAD(P) binding site [chemical binding]; other site
999541008253	active site
999541008254	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541008255	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008256	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
999541008257	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
999541008258	phosphate binding site [ion binding]; other site
999541008259	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541008260	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541008261	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541008262	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541008263	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541008264	hypothetical protein; Validated; Region: PRK06201
999541008265	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
999541008266	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
999541008267	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
999541008268	NAD binding site [chemical binding]; other site
999541008269	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
999541008270	Strictosidine synthase; Region: Str_synth; pfam03088
999541008271	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541008272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008273	putative substrate translocation pore; other site
999541008274	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541008275	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541008276	trimer interface [polypeptide binding]; other site
999541008277	eyelet of channel; other site
999541008278	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541008279	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541008280	benzoate transport; Region: 2A0115; TIGR00895
999541008281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008282	putative substrate translocation pore; other site
999541008283	H+ Antiporter protein; Region: 2A0121; TIGR00900
999541008284	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541008285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008286	putative substrate translocation pore; other site
999541008287	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541008288	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
999541008289	active site
999541008290	Isochorismatase family; Region: Isochorismatase; pfam00857
999541008291	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
999541008292	catalytic triad [active]
999541008293	conserved cis-peptide bond; other site
999541008294	SnoaL-like domain; Region: SnoaL_2; pfam12680
999541008295	benzoate transport; Region: 2A0115; TIGR00895
999541008296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008297	putative substrate translocation pore; other site
999541008298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008299	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
999541008300	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541008301	NADP binding site [chemical binding]; other site
999541008302	putative substrate binding site [chemical binding]; other site
999541008303	active site
999541008304	Cupin; Region: Cupin_6; pfam12852
999541008305	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541008306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541008308	salt bridge; other site
999541008309	non-specific DNA binding site [nucleotide binding]; other site
999541008310	sequence-specific DNA binding site [nucleotide binding]; other site
999541008311	classical (c) SDRs; Region: SDR_c; cd05233
999541008312	short chain dehydrogenase; Provisional; Region: PRK07041
999541008313	NAD(P) binding site [chemical binding]; other site
999541008314	active site
999541008315	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541008316	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541008317	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
999541008318	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
999541008319	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
999541008320	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541008321	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
999541008322	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541008323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008324	Integrase core domain; Region: rve; pfam00665
999541008325	Integrase core domain; Region: rve_3; cl15866
999541008326	LysR family transcriptional regulator; Provisional; Region: PRK14997
999541008327	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008328	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008329	putative effector binding pocket; other site
999541008330	dimerization interface [polypeptide binding]; other site
999541008331	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
999541008332	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
999541008333	potential catalytic triad [active]
999541008334	conserved cys residue [active]
999541008335	Uncharacterized conserved protein [Function unknown]; Region: COG1359
999541008336	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
999541008337	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
999541008338	putative NAD(P) binding site [chemical binding]; other site
999541008339	dimer interface [polypeptide binding]; other site
999541008340	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541008341	TAP-like protein; Region: Abhydrolase_4; pfam08386
999541008342	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
999541008343	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
999541008344	putative NAD(P) binding site [chemical binding]; other site
999541008345	putative substrate binding site [chemical binding]; other site
999541008346	catalytic Zn binding site [ion binding]; other site
999541008347	structural Zn binding site [ion binding]; other site
999541008348	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541008349	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
999541008350	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541008351	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541008352	conserved cys residue [active]
999541008353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541008355	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541008356	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541008357	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541008358	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541008359	Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851
999541008360	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
999541008361	active site 1 [active]
999541008362	dimer interface [polypeptide binding]; other site
999541008363	hexamer interface [polypeptide binding]; other site
999541008364	active site 2 [active]
999541008365	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541008366	classical (c) SDRs; Region: SDR_c; cd05233
999541008367	NAD(P) binding site [chemical binding]; other site
999541008368	active site
999541008369	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008370	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008371	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541008372	dimerization interface [polypeptide binding]; other site
999541008373	Phosphotransferase enzyme family; Region: APH; pfam01636
999541008374	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
999541008375	active site
999541008376	ATP binding site [chemical binding]; other site
999541008377	substrate binding site [chemical binding]; other site
999541008378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541008379	dimerization interface [polypeptide binding]; other site
999541008380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541008381	PAS domain; Region: PAS_9; pfam13426
999541008382	putative active site [active]
999541008383	heme pocket [chemical binding]; other site
999541008384	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541008385	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541008386	metal binding site [ion binding]; metal-binding site
999541008387	active site
999541008388	I-site; other site
999541008389	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541008390	hypothetical protein; Provisional; Region: PRK05208
999541008391	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541008392	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
999541008393	non-specific DNA binding site [nucleotide binding]; other site
999541008394	salt bridge; other site
999541008395	sequence-specific DNA binding site [nucleotide binding]; other site
999541008396	Cupin domain; Region: Cupin_2; cl17218
999541008397	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541008398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541008399	Coenzyme A binding pocket [chemical binding]; other site
999541008400	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
999541008401	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
999541008402	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
999541008403	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541008404	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541008405	putative DNA binding site [nucleotide binding]; other site
999541008406	putative Zn2+ binding site [ion binding]; other site
999541008407	AsnC family; Region: AsnC_trans_reg; pfam01037
999541008408	methionine gamma-lyase; Validated; Region: PRK07049
999541008409	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
999541008410	homodimer interface [polypeptide binding]; other site
999541008411	substrate-cofactor binding pocket; other site
999541008412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541008413	catalytic residue [active]
999541008414	benzoate transport; Region: 2A0115; TIGR00895
999541008415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008416	putative substrate translocation pore; other site
999541008417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008418	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
999541008419	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
999541008420	putative active site [active]
999541008421	metal binding site [ion binding]; metal-binding site
999541008422	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
999541008423	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541008424	motif II; other site
999541008425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008426	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
999541008427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541008428	dimerization interface [polypeptide binding]; other site
999541008429	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
999541008430	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
999541008431	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
999541008432	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
999541008433	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
999541008434	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
999541008435	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
999541008436	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
999541008437	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
999541008438	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541008439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008440	Predicted membrane protein [Function unknown]; Region: COG2860
999541008441	UPF0126 domain; Region: UPF0126; pfam03458
999541008442	UPF0126 domain; Region: UPF0126; pfam03458
999541008443	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
999541008444	HTH domain; Region: HTH_11; pfam08279
999541008445	Predicted transcriptional regulator [Transcription]; Region: COG2378
999541008446	WYL domain; Region: WYL; pfam13280
999541008447	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
999541008448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541008449	DNA-binding site [nucleotide binding]; DNA binding site
999541008450	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541008451	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541008452	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541008453	homodimer interface [polypeptide binding]; other site
999541008454	catalytic residue [active]
999541008455	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
999541008456	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
999541008457	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
999541008458	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
999541008459	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
999541008460	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
999541008461	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
999541008462	heme binding pocket [chemical binding]; other site
999541008463	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
999541008464	domain interactions; other site
999541008465	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541008466	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
999541008467	catalytic site [active]
999541008468	TAP-like protein; Region: Abhydrolase_4; pfam08386
999541008469	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
999541008470	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541008471	putative ligand binding site [chemical binding]; other site
999541008472	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541008473	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541008474	Walker A/P-loop; other site
999541008475	ATP binding site [chemical binding]; other site
999541008476	Q-loop/lid; other site
999541008477	ABC transporter signature motif; other site
999541008478	Walker B; other site
999541008479	D-loop; other site
999541008480	H-loop/switch region; other site
999541008481	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541008482	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541008483	TM-ABC transporter signature motif; other site
999541008484	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541008485	TM-ABC transporter signature motif; other site
999541008486	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541008487	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
999541008488	active site
999541008489	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541008490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008491	ATP binding site [chemical binding]; other site
999541008492	Mg2+ binding site [ion binding]; other site
999541008493	G-X-G motif; other site
999541008494	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
999541008495	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
999541008496	catalytic residues [active]
999541008497	short chain dehydrogenase; Provisional; Region: PRK06197
999541008498	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
999541008499	putative NAD(P) binding site [chemical binding]; other site
999541008500	active site
999541008501	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
999541008502	NADH(P)-binding; Region: NAD_binding_10; pfam13460
999541008503	NAD binding site [chemical binding]; other site
999541008504	substrate binding site [chemical binding]; other site
999541008505	putative active site [active]
999541008506	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541008507	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541008508	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541008509	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541008510	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
999541008511	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
999541008512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541008513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008514	dimer interface [polypeptide binding]; other site
999541008515	phosphorylation site [posttranslational modification]
999541008516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008517	ATP binding site [chemical binding]; other site
999541008518	Mg2+ binding site [ion binding]; other site
999541008519	G-X-G motif; other site
999541008520	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541008521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008522	active site
999541008523	phosphorylation site [posttranslational modification]
999541008524	intermolecular recognition site; other site
999541008525	dimerization interface [polypeptide binding]; other site
999541008526	Response regulator receiver domain; Region: Response_reg; pfam00072
999541008527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008528	active site
999541008529	phosphorylation site [posttranslational modification]
999541008530	intermolecular recognition site; other site
999541008531	dimerization interface [polypeptide binding]; other site
999541008532	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541008533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008534	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
999541008535	active site
999541008536	catalytic residues [active]
999541008537	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
999541008538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541008539	Walker A/P-loop; other site
999541008540	ATP binding site [chemical binding]; other site
999541008541	Q-loop/lid; other site
999541008542	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541008543	ABC transporter; Region: ABC_tran_2; pfam12848
999541008544	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541008545	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
999541008546	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
999541008547	active site
999541008548	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
999541008549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541008550	Coenzyme A binding pocket [chemical binding]; other site
999541008551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541008552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008553	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541008554	putative substrate translocation pore; other site
999541008555	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541008556	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541008557	metal binding site [ion binding]; metal-binding site
999541008558	putative dimer interface [polypeptide binding]; other site
999541008559	Domain of unknown function (DUF305); Region: DUF305; cl17794
999541008560	malate dehydrogenase; Provisional; Region: PRK05442
999541008561	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
999541008562	NAD(P) binding site [chemical binding]; other site
999541008563	dimer interface [polypeptide binding]; other site
999541008564	malate binding site [chemical binding]; other site
999541008565	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
999541008566	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
999541008567	catalytic triad [active]
999541008568	dimer interface [polypeptide binding]; other site
999541008569	Isochorismatase family; Region: Isochorismatase; pfam00857
999541008570	conserved cis-peptide bond; other site
999541008571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008573	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008574	putative effector binding pocket; other site
999541008575	dimerization interface [polypeptide binding]; other site
999541008576	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
999541008577	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
999541008578	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
999541008579	active site
999541008580	DoxX; Region: DoxX; pfam07681
999541008581	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541008582	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
999541008583	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
999541008584	putative heme binding pocket [chemical binding]; other site
999541008585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541008586	dimerization interface [polypeptide binding]; other site
999541008587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008588	dimer interface [polypeptide binding]; other site
999541008589	phosphorylation site [posttranslational modification]
999541008590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008591	ATP binding site [chemical binding]; other site
999541008592	Mg2+ binding site [ion binding]; other site
999541008593	G-X-G motif; other site
999541008594	osmolarity response regulator; Provisional; Region: ompR; PRK09468
999541008595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008596	active site
999541008597	phosphorylation site [posttranslational modification]
999541008598	intermolecular recognition site; other site
999541008599	dimerization interface [polypeptide binding]; other site
999541008600	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541008601	DNA binding site [nucleotide binding]
999541008602	MltA-interacting protein MipA; Region: MipA; cl01504
999541008603	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
999541008604	Cytochrome P450; Region: p450; cl12078
999541008605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541008606	WHG domain; Region: WHG; pfam13305
999541008607	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
999541008608	Protein export membrane protein; Region: SecD_SecF; cl14618
999541008609	D-lactate dehydrogenase; Provisional; Region: PRK11183
999541008610	FAD binding domain; Region: FAD_binding_4; pfam01565
999541008611	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
999541008612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008613	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
999541008614	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
999541008615	putative dimerization interface [polypeptide binding]; other site
999541008616	putative substrate binding pocket [chemical binding]; other site
999541008617	Uncharacterized conserved protein [Function unknown]; Region: COG2128
999541008618	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
999541008619	Cupin domain; Region: Cupin_2; pfam07883
999541008620	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
999541008621	Beta-lactamase; Region: Beta-lactamase; pfam00144
999541008622	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
999541008623	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
999541008624	HAMP domain; Region: HAMP; pfam00672
999541008625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541008626	dimer interface [polypeptide binding]; other site
999541008627	phosphorylation site [posttranslational modification]
999541008628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541008629	ATP binding site [chemical binding]; other site
999541008630	Mg2+ binding site [ion binding]; other site
999541008631	G-X-G motif; other site
999541008632	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
999541008633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541008634	active site
999541008635	phosphorylation site [posttranslational modification]
999541008636	intermolecular recognition site; other site
999541008637	dimerization interface [polypeptide binding]; other site
999541008638	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541008639	DNA binding site [nucleotide binding]
999541008640	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541008641	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541008642	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541008643	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541008644	trimer interface [polypeptide binding]; other site
999541008645	eyelet of channel; other site
999541008646	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008648	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541008649	dimerization interface [polypeptide binding]; other site
999541008650	Predicted membrane protein [Function unknown]; Region: COG3817
999541008651	Protein of unknown function (DUF979); Region: DUF979; pfam06166
999541008652	Protein of unknown function (DUF969); Region: DUF969; pfam06149
999541008653	5-oxoprolinase; Region: PLN02666
999541008654	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
999541008655	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
999541008656	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
999541008657	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
999541008658	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
999541008659	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541008660	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541008661	Magnesium ion binding site [ion binding]; other site
999541008662	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
999541008663	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
999541008664	DXD motif; other site
999541008665	PilZ domain; Region: PilZ; pfam07238
999541008666	cellulose synthase regulator protein; Provisional; Region: PRK11114
999541008667	endo-1,4-D-glucanase; Provisional; Region: PRK11097
999541008668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541008669	binding surface
999541008670	TPR motif; other site
999541008671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541008672	TPR motif; other site
999541008673	binding surface
999541008674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541008675	TPR motif; other site
999541008676	Tetratricopeptide repeat; Region: TPR_16; pfam13432
999541008677	binding surface
999541008678	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
999541008679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008681	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008682	putative effector binding pocket; other site
999541008683	dimerization interface [polypeptide binding]; other site
999541008684	Major royal jelly protein; Region: MRJP; pfam03022
999541008685	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541008686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008687	putative substrate translocation pore; other site
999541008688	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541008689	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541008690	dimerization interface [polypeptide binding]; other site
999541008691	ligand binding site [chemical binding]; other site
999541008692	ornithine cyclodeaminase; Validated; Region: PRK07589
999541008693	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
999541008694	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
999541008695	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
999541008696	active site
999541008697	Zn binding site [ion binding]; other site
999541008698	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541008699	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
999541008700	putative DNA binding site [nucleotide binding]; other site
999541008701	putative Zn2+ binding site [ion binding]; other site
999541008702	AsnC family; Region: AsnC_trans_reg; pfam01037
999541008703	Oxidoreductase FAD-binding domain; Region: FAD_binding_6; pfam00970
999541008704	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
999541008705	FAD binding pocket [chemical binding]; other site
999541008706	conserved FAD binding motif [chemical binding]; other site
999541008707	phosphate binding motif [ion binding]; other site
999541008708	beta-alpha-beta structure motif; other site
999541008709	NAD binding pocket [chemical binding]; other site
999541008710	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541008711	catalytic loop [active]
999541008712	iron binding site [ion binding]; other site
999541008713	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
999541008714	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
999541008715	EamA-like transporter family; Region: EamA; pfam00892
999541008716	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
999541008717	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
999541008718	active site
999541008719	dimer interface [polypeptide binding]; other site
999541008720	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
999541008721	Ligand Binding Site [chemical binding]; other site
999541008722	Molecular Tunnel; other site
999541008723	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
999541008724	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541008725	substrate binding site [chemical binding]; other site
999541008726	oxyanion hole (OAH) forming residues; other site
999541008727	trimer interface [polypeptide binding]; other site
999541008728	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541008729	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541008730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541008731	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
999541008732	Predicted membrane protein [Function unknown]; Region: COG4541
999541008733	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
999541008734	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541008735	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541008736	putative DNA binding site [nucleotide binding]; other site
999541008737	putative Zn2+ binding site [ion binding]; other site
999541008738	AsnC family; Region: AsnC_trans_reg; pfam01037
999541008739	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
999541008740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541008741	S-adenosylmethionine binding site [chemical binding]; other site
999541008742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008743	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008744	putative effector binding pocket; other site
999541008745	dimerization interface [polypeptide binding]; other site
999541008746	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
999541008747	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541008748	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
999541008749	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
999541008750	active site
999541008751	catalytic triad [active]
999541008752	oxyanion hole [active]
999541008753	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
999541008754	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
999541008755	heme binding site [chemical binding]; other site
999541008756	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
999541008757	heme binding site [chemical binding]; other site
999541008758	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
999541008759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008760	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541008761	dimerization interface [polypeptide binding]; other site
999541008762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541008763	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541008764	substrate binding pocket [chemical binding]; other site
999541008765	membrane-bound complex binding site; other site
999541008766	hinge residues; other site
999541008767	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
999541008768	active site
999541008769	Zn binding site [ion binding]; other site
999541008770	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
999541008771	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
999541008772	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541008773	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541008774	eyelet of channel; other site
999541008775	trimer interface [polypeptide binding]; other site
999541008776	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
999541008777	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
999541008778	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541008779	putative PBP binding regions; other site
999541008780	ABC-ATPase subunit  interface; other site
999541008781	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547
999541008782	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541008783	Walker A/P-loop; other site
999541008784	ATP binding site [chemical binding]; other site
999541008785	Q-loop/lid; other site
999541008786	ABC transporter signature motif; other site
999541008787	Walker B; other site
999541008788	D-loop; other site
999541008789	H-loop/switch region; other site
999541008790	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
999541008791	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
999541008792	tetramer interface [polypeptide binding]; other site
999541008793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541008794	catalytic residue [active]
999541008795	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541008796	MarR family; Region: MarR_2; pfam12802
999541008797	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
999541008798	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
999541008799	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
999541008800	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
999541008801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008803	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541008804	putative effector binding pocket; other site
999541008805	dimerization interface [polypeptide binding]; other site
999541008806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541008807	short chain dehydrogenase; Provisional; Region: PRK07041
999541008808	NAD(P) binding site [chemical binding]; other site
999541008809	active site
999541008810	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
999541008811	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541008812	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
999541008813	FMN binding site [chemical binding]; other site
999541008814	active site
999541008815	substrate binding site [chemical binding]; other site
999541008816	catalytic residue [active]
999541008817	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
999541008818	dimer interface [polypeptide binding]; other site
999541008819	putative metal binding site [ion binding]; other site
999541008820	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
999541008821	active site lid residues [active]
999541008822	substrate binding pocket [chemical binding]; other site
999541008823	catalytic residues [active]
999541008824	substrate-Mg2+ binding site; other site
999541008825	aspartate-rich region 1; other site
999541008826	aspartate-rich region 2; other site
999541008827	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
999541008828	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
999541008829	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
999541008830	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
999541008831	DNA binding residues [nucleotide binding]
999541008832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541008833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008834	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541008835	dimerization interface [polypeptide binding]; other site
999541008836	drug efflux system protein MdtG; Provisional; Region: PRK09874
999541008837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008839	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
999541008840	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
999541008841	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
999541008842	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
999541008843	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
999541008844	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
999541008845	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
999541008846	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541008847	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
999541008848	metal-binding site [ion binding]
999541008849	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
999541008850	metal-binding site [ion binding]
999541008851	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
999541008852	metal-binding site [ion binding]
999541008853	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
999541008854	metal-binding site [ion binding]
999541008855	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
999541008856	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
999541008857	metal-binding site [ion binding]
999541008858	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
999541008859	Predicted membrane protein [Function unknown]; Region: COG2860
999541008860	UPF0126 domain; Region: UPF0126; pfam03458
999541008861	UPF0126 domain; Region: UPF0126; pfam03458
999541008862	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
999541008863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008864	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
999541008865	putative dimerization interface [polypeptide binding]; other site
999541008866	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
999541008867	MgtC family; Region: MgtC; pfam02308
999541008868	dimerization interface [polypeptide binding]; other site
999541008869	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
999541008870	putative active cleft [active]
999541008871	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541008872	CoenzymeA binding site [chemical binding]; other site
999541008873	subunit interaction site [polypeptide binding]; other site
999541008874	PHB binding site; other site
999541008875	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541008876	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541008877	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
999541008878	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
999541008879	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
999541008880	substrate binding site [chemical binding]; other site
999541008881	ligand binding site [chemical binding]; other site
999541008882	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
999541008883	substrate binding site [chemical binding]; other site
999541008884	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
999541008885	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
999541008886	dimer interface [polypeptide binding]; other site
999541008887	active site
999541008888	citrylCoA binding site [chemical binding]; other site
999541008889	oxalacetate/citrate binding site [chemical binding]; other site
999541008890	coenzyme A binding site [chemical binding]; other site
999541008891	catalytic triad [active]
999541008892	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
999541008893	tetramer interface [polypeptide binding]; other site
999541008894	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
999541008895	active site
999541008896	Mg2+/Mn2+ binding site [ion binding]; other site
999541008897	Propionate catabolism activator; Region: PrpR_N; pfam06506
999541008898	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
999541008899	PAS domain; Region: PAS; smart00091
999541008900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541008901	Walker A motif; other site
999541008902	ATP binding site [chemical binding]; other site
999541008903	Walker B motif; other site
999541008904	arginine finger; other site
999541008905	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541008906	peroxiredoxin; Region: AhpC; TIGR03137
999541008907	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
999541008908	dimer interface [polypeptide binding]; other site
999541008909	decamer (pentamer of dimers) interface [polypeptide binding]; other site
999541008910	catalytic triad [active]
999541008911	peroxidatic and resolving cysteines [active]
999541008912	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
999541008913	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
999541008914	catalytic residue [active]
999541008915	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
999541008916	catalytic residues [active]
999541008917	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541008918	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541008919	Peptidase S46; Region: Peptidase_S46; pfam10459
999541008920	Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949
999541008921	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541008922	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541008923	N-terminal plug; other site
999541008924	ligand-binding site [chemical binding]; other site
999541008925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541008926	PAS domain; Region: PAS_9; pfam13426
999541008927	putative active site [active]
999541008928	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541008929	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541008930	metal binding site [ion binding]; metal-binding site
999541008931	active site
999541008932	I-site; other site
999541008933	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541008934	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541008935	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541008936	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541008937	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541008938	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541008939	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
999541008940	CoA binding domain; Region: CoA_binding_2; pfam13380
999541008941	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
999541008942	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541008943	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541008944	H-NS histone family; Region: Histone_HNS; pfam00816
999541008945	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541008946	PAS fold; Region: PAS_4; pfam08448
999541008947	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541008948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541008949	Walker B motif; other site
999541008950	arginine finger; other site
999541008951	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
999541008952	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
999541008953	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
999541008954	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
999541008955	active site residue [active]
999541008956	outer membrane porin, OprD family; Region: OprD; pfam03573
999541008957	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
999541008958	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541008959	non-specific DNA binding site [nucleotide binding]; other site
999541008960	salt bridge; other site
999541008961	sequence-specific DNA binding site [nucleotide binding]; other site
999541008962	Cupin domain; Region: Cupin_2; pfam07883
999541008963	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
999541008964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008965	putative substrate translocation pore; other site
999541008966	POT family; Region: PTR2; cl17359
999541008967	OpgC protein; Region: OpgC_C; pfam10129
999541008968	Acyltransferase family; Region: Acyl_transf_3; pfam01757
999541008969	Predicted permeases [General function prediction only]; Region: RarD; COG2962
999541008970	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
999541008971	acylphosphatase; Provisional; Region: PRK14424
999541008972	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
999541008973	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
999541008974	putative NADP binding site [chemical binding]; other site
999541008975	putative substrate binding site [chemical binding]; other site
999541008976	active site
999541008977	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
999541008978	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
999541008979	active site
999541008980	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541008981	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
999541008982	LytB protein; Region: LYTB; pfam02401
999541008983	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
999541008984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541008985	FeS/SAM binding site; other site
999541008986	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
999541008987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541008988	D-galactonate transporter; Region: 2A0114; TIGR00893
999541008989	putative substrate translocation pore; other site
999541008990	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
999541008991	tartrate dehydrogenase; Region: TTC; TIGR02089
999541008992	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
999541008993	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541008994	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
999541008995	putative effector binding pocket; other site
999541008996	putative dimerization interface [polypeptide binding]; other site
999541008997	Chromate transporter; Region: Chromate_transp; pfam02417
999541008998	Chromate transporter; Region: Chromate_transp; pfam02417
999541008999	Flagellar protein YcgR; Region: YcgR_2; pfam12945
999541009000	PilZ domain; Region: PilZ; pfam07238
999541009001	Protein of unknown function (DUF466); Region: DUF466; pfam04328
999541009002	carbon starvation protein A; Provisional; Region: PRK15015
999541009003	Carbon starvation protein CstA; Region: CstA; pfam02554
999541009004	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
999541009005	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
999541009006	substrate binding pocket [chemical binding]; other site
999541009007	membrane-bound complex binding site; other site
999541009008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541009009	non-specific DNA binding site [nucleotide binding]; other site
999541009010	salt bridge; other site
999541009011	sequence-specific DNA binding site [nucleotide binding]; other site
999541009012	Domain of unknown function (DUF955); Region: DUF955; cl01076
999541009013	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
999541009014	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541009015	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541009016	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541009017	trimer interface [polypeptide binding]; other site
999541009018	eyelet of channel; other site
999541009019	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
999541009020	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541009021	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
999541009022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541009023	FeS/SAM binding site; other site
999541009024	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
999541009025	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
999541009026	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
999541009027	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
999541009028	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
999541009029	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
999541009030	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
999541009031	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
999541009032	NAD(P) binding site [chemical binding]; other site
999541009033	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541009034	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541009035	tetramerization interface [polypeptide binding]; other site
999541009036	NAD(P) binding site [chemical binding]; other site
999541009037	catalytic residues [active]
999541009038	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541009039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541009040	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541009041	putative effector binding pocket; other site
999541009042	dimerization interface [polypeptide binding]; other site
999541009043	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
999541009044	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541009045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541009046	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541009047	putative effector binding pocket; other site
999541009048	dimerization interface [polypeptide binding]; other site
999541009049	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
999541009050	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
999541009051	potential catalytic triad [active]
999541009052	conserved cys residue [active]
999541009053	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541009054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541009055	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541009056	dimerization interface [polypeptide binding]; other site
999541009057	substrate binding pocket [chemical binding]; other site
999541009058	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541009059	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541009060	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
999541009061	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
999541009062	CGNR zinc finger; Region: zf-CGNR; pfam11706
999541009063	short chain dehydrogenase; Provisional; Region: PRK06500
999541009064	classical (c) SDRs; Region: SDR_c; cd05233
999541009065	NAD(P) binding site [chemical binding]; other site
999541009066	active site
999541009067	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541009068	EamA-like transporter family; Region: EamA; pfam00892
999541009069	EamA-like transporter family; Region: EamA; pfam00892
999541009070	Uncharacterized conserved protein [Function unknown]; Region: COG5476
999541009071	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
999541009072	MlrC C-terminus; Region: MlrC_C; pfam07171
999541009073	allantoate amidohydrolase; Reviewed; Region: PRK12893
999541009074	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
999541009075	active site
999541009076	metal binding site [ion binding]; metal-binding site
999541009077	dimer interface [polypeptide binding]; other site
999541009078	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541009079	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541009080	Walker A/P-loop; other site
999541009081	ATP binding site [chemical binding]; other site
999541009082	Q-loop/lid; other site
999541009083	ABC transporter signature motif; other site
999541009084	Walker B; other site
999541009085	D-loop; other site
999541009086	H-loop/switch region; other site
999541009087	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541009088	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541009089	Walker A/P-loop; other site
999541009090	ATP binding site [chemical binding]; other site
999541009091	Q-loop/lid; other site
999541009092	ABC transporter signature motif; other site
999541009093	Walker B; other site
999541009094	D-loop; other site
999541009095	H-loop/switch region; other site
999541009096	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541009097	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541009098	TM-ABC transporter signature motif; other site
999541009099	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541009100	TM-ABC transporter signature motif; other site
999541009101	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
999541009102	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
999541009103	putative ligand binding site [chemical binding]; other site
999541009104	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541009105	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541009106	DNA-binding site [nucleotide binding]; DNA binding site
999541009107	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541009108	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541009109	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541009110	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541009111	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
999541009112	Transglycosylase; Region: Transgly; pfam00912
999541009113	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541009114	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
999541009115	Protein export membrane protein; Region: SecD_SecF; cl14618
999541009116	putative acetyltransferase YhhY; Provisional; Region: PRK10140
999541009117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541009118	Coenzyme A binding pocket [chemical binding]; other site
999541009119	putative acetyltransferase YhhY; Provisional; Region: PRK10140
999541009120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541009121	Coenzyme A binding pocket [chemical binding]; other site
999541009122	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
999541009123	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
999541009124	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
999541009125	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541009126	Walker A/P-loop; other site
999541009127	ATP binding site [chemical binding]; other site
999541009128	Q-loop/lid; other site
999541009129	ABC transporter signature motif; other site
999541009130	Walker B; other site
999541009131	D-loop; other site
999541009132	H-loop/switch region; other site
999541009133	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541009134	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541009135	Walker A/P-loop; other site
999541009136	ATP binding site [chemical binding]; other site
999541009137	Q-loop/lid; other site
999541009138	ABC transporter signature motif; other site
999541009139	Walker B; other site
999541009140	D-loop; other site
999541009141	H-loop/switch region; other site
999541009142	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
999541009143	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
999541009144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541009145	dimer interface [polypeptide binding]; other site
999541009146	conserved gate region; other site
999541009147	putative PBP binding loops; other site
999541009148	ABC-ATPase subunit interface; other site
999541009149	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
999541009150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541009151	dimer interface [polypeptide binding]; other site
999541009152	conserved gate region; other site
999541009153	putative PBP binding loops; other site
999541009154	ABC-ATPase subunit interface; other site
999541009155	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
999541009156	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
999541009157	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
999541009158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
999541009159	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
999541009160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541009161	non-specific DNA binding site [nucleotide binding]; other site
999541009162	salt bridge; other site
999541009163	sequence-specific DNA binding site [nucleotide binding]; other site
999541009164	Cupin domain; Region: Cupin_2; pfam07883
999541009165	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
999541009166	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541009167	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
999541009168	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541009169	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
999541009170	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
999541009171	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
999541009172	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
999541009173	Response regulator receiver domain; Region: Response_reg; pfam00072
999541009174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009175	active site
999541009176	phosphorylation site [posttranslational modification]
999541009177	intermolecular recognition site; other site
999541009178	dimerization interface [polypeptide binding]; other site
999541009179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541009180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541009181	dimer interface [polypeptide binding]; other site
999541009182	phosphorylation site [posttranslational modification]
999541009183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009184	ATP binding site [chemical binding]; other site
999541009185	Mg2+ binding site [ion binding]; other site
999541009186	G-X-G motif; other site
999541009187	Response regulator receiver domain; Region: Response_reg; pfam00072
999541009188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009189	active site
999541009190	phosphorylation site [posttranslational modification]
999541009191	intermolecular recognition site; other site
999541009192	dimerization interface [polypeptide binding]; other site
999541009193	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
999541009194	anti sigma factor interaction site; other site
999541009195	regulatory phosphorylation site [posttranslational modification]; other site
999541009196	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541009197	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541009198	substrate binding pocket [chemical binding]; other site
999541009199	membrane-bound complex binding site; other site
999541009200	hinge residues; other site
999541009201	PAS domain S-box; Region: sensory_box; TIGR00229
999541009202	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541009203	putative active site [active]
999541009204	heme pocket [chemical binding]; other site
999541009205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541009206	PAS domain; Region: PAS_9; pfam13426
999541009207	putative active site [active]
999541009208	heme pocket [chemical binding]; other site
999541009209	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
999541009210	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
999541009211	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
999541009212	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541009213	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541009214	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
999541009215	Probable Catalytic site; other site
999541009216	metal-binding site
999541009217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541009218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009219	active site
999541009220	phosphorylation site [posttranslational modification]
999541009221	intermolecular recognition site; other site
999541009222	dimerization interface [polypeptide binding]; other site
999541009223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541009224	DNA binding site [nucleotide binding]
999541009225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
999541009226	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
999541009227	Histidine kinase; Region: HisKA_3; pfam07730
999541009228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009229	ATP binding site [chemical binding]; other site
999541009230	Mg2+ binding site [ion binding]; other site
999541009231	G-X-G motif; other site
999541009232	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541009233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009234	active site
999541009235	phosphorylation site [posttranslational modification]
999541009236	intermolecular recognition site; other site
999541009237	dimerization interface [polypeptide binding]; other site
999541009238	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541009239	DNA binding residues [nucleotide binding]
999541009240	dimerization interface [polypeptide binding]; other site
999541009241	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
999541009242	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
999541009243	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
999541009244	VacJ like lipoprotein; Region: VacJ; cl01073
999541009245	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
999541009246	hypothetical protein; Provisional; Region: PRK07483
999541009247	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541009248	inhibitor-cofactor binding pocket; inhibition site
999541009249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541009250	catalytic residue [active]
999541009251	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
999541009252	hypothetical protein; Provisional; Region: PRK07077
999541009253	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
999541009254	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
999541009255	Active site cavity [active]
999541009256	catalytic acid [active]
999541009257	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
999541009258	active site lid residues [active]
999541009259	substrate binding pocket [chemical binding]; other site
999541009260	catalytic residues [active]
999541009261	substrate-Mg2+ binding site; other site
999541009262	aspartate-rich region 1; other site
999541009263	aspartate-rich region 2; other site
999541009264	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
999541009265	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541009266	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
999541009267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541009268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009269	ATP binding site [chemical binding]; other site
999541009270	Mg2+ binding site [ion binding]; other site
999541009271	G-X-G motif; other site
999541009272	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541009273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009274	active site
999541009275	phosphorylation site [posttranslational modification]
999541009276	intermolecular recognition site; other site
999541009277	dimerization interface [polypeptide binding]; other site
999541009278	Predicted flavoprotein [General function prediction only]; Region: COG0431
999541009279	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541009280	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
999541009281	ArsC family; Region: ArsC; pfam03960
999541009282	catalytic residues [active]
999541009283	ParA-like protein; Provisional; Region: PHA02518
999541009284	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009285	P-loop; other site
999541009286	Magnesium ion binding site [ion binding]; other site
999541009287	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
999541009288	ParB-like nuclease domain; Region: ParB; smart00470
999541009289	Initiator Replication protein; Region: Rep_3; pfam01051
999541009290	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
999541009291	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
999541009292	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541009293	trimer interface [polypeptide binding]; other site
999541009294	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541009295	trimer interface [polypeptide binding]; other site
999541009296	YadA-like C-terminal region; Region: YadA; pfam03895
999541009297	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
999541009298	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
999541009299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541009300	Zeta toxin; Region: Zeta_toxin; pfam06414
999541009301	Walker A motif; other site
999541009302	ATP binding site [chemical binding]; other site
999541009303	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
999541009304	PLD-like domain; Region: PLDc_2; pfam13091
999541009305	putative active site [active]
999541009306	catalytic site [active]
999541009307	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
999541009308	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
999541009309	F plasmid transfer operon protein; Region: TraF; pfam13728
999541009310	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
999541009311	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
999541009312	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
999541009313	TraU protein; Region: TraU; pfam06834
999541009314	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
999541009315	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
999541009316	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
999541009317	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
999541009318	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
999541009319	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
999541009320	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
999541009321	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
999541009322	dimerization domain [polypeptide binding]; other site
999541009323	dimer interface [polypeptide binding]; other site
999541009324	catalytic residues [active]
999541009325	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
999541009326	TraK protein; Region: TraK; pfam06586
999541009327	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
999541009328	TraE protein; Region: TraE; cl05060
999541009329	TraL protein; Region: TraL; cl06278
999541009330	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541009331	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541009332	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541009333	catalytic residue [active]
999541009334	BetR domain; Region: BetR; pfam08667
999541009335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009336	active site
999541009337	phosphorylation site [posttranslational modification]
999541009338	intermolecular recognition site; other site
999541009339	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541009340	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541009341	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
999541009342	dimer interface [polypeptide binding]; other site
999541009343	phosphorylation site [posttranslational modification]
999541009344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009345	ATP binding site [chemical binding]; other site
999541009346	Mg2+ binding site [ion binding]; other site
999541009347	G-X-G motif; other site
999541009348	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
999541009349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541009350	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541009351	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541009352	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541009353	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541009354	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
999541009355	PAAR motif; Region: PAAR_motif; pfam05488
999541009356	PAAR motif; Region: PAAR_motif; pfam05488
999541009357	TrwC relaxase; Region: TrwC; pfam08751
999541009358	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
999541009359	AAA domain; Region: AAA_30; pfam13604
999541009360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541009361	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541009362	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541009363	F sex factor protein N terminal; Region: TraD_N; pfam12615
999541009364	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541009365	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
999541009366	Walker A motif; other site
999541009367	ATP binding site [chemical binding]; other site
999541009368	Walker B motif; other site
999541009369	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
999541009370	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
999541009371	ParB-like nuclease domain; Region: ParBc; pfam02195
999541009372	DNA methylase; Region: N6_N4_Mtase; cl17433
999541009373	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
999541009374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541009375	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541009376	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541009377	Domain of unknown function (DUF932); Region: DUF932; pfam06067
999541009378	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
999541009379	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
999541009380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541009381	active site
999541009382	motif I; other site
999541009383	motif II; other site
999541009384	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
999541009385	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541009386	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541009387	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541009388	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541009389	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
999541009390	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541009391	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541009392	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541009393	CHAT domain; Region: CHAT; cl17868
999541009394	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541009395	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
999541009396	active site
999541009397	metal binding site [ion binding]; metal-binding site
999541009398	H-NS histone family; Region: Histone_HNS; pfam00816
999541009399	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541009400	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
999541009401	Uncharacterized conserved protein [Function unknown]; Region: COG4544
999541009402	DNA Polymerase Y-family; Region: PolY_like; cd03468
999541009403	active site
999541009404	DNA binding site [nucleotide binding]
999541009405	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
999541009406	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
999541009407	putative active site [active]
999541009408	putative PHP Thumb interface [polypeptide binding]; other site
999541009409	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
999541009410	generic binding surface II; other site
999541009411	generic binding surface I; other site
999541009412	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541009413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541009414	non-specific DNA binding site [nucleotide binding]; other site
999541009415	salt bridge; other site
999541009416	sequence-specific DNA binding site [nucleotide binding]; other site
999541009417	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
999541009418	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
999541009419	Phage integrase protein; Region: DUF3701; pfam12482
999541009420	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
999541009421	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541009422	active site
999541009423	DNA binding site [nucleotide binding]
999541009424	Int/Topo IB signature motif; other site
999541009425	FRG domain; Region: FRG; pfam08867
999541009426	RES domain; Region: RES; pfam08808
999541009427	plasmid-partitioning protein RepA; Provisional; Region: PRK13869
999541009428	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009429	P-loop; other site
999541009430	Magnesium ion binding site [ion binding]; other site
999541009431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541009432	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009433	Magnesium ion binding site [ion binding]; other site
999541009434	ParB-like nuclease domain; Region: ParB; smart00470
999541009435	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
999541009436	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541009437	active site
999541009438	DNA binding site [nucleotide binding]
999541009439	Int/Topo IB signature motif; other site
999541009440	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
999541009441	Predicted transcriptional regulators [Transcription]; Region: COG1510
999541009442	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
999541009443	ParB-like nuclease domain; Region: ParB; smart00470
999541009444	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009445	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
999541009446	P-loop; other site
999541009447	Magnesium ion binding site [ion binding]; other site
999541009448	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009449	Magnesium ion binding site [ion binding]; other site
999541009450	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
999541009451	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
999541009452	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
999541009453	metal ion-dependent adhesion site (MIDAS); other site
999541009454	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
999541009455	H-NS histone family; Region: Histone_HNS; pfam00816
999541009456	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541009457	Methyltransferase TYW3; Region: TYW3; cl00689
999541009458	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541009459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541009460	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541009461	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541009462	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541009463	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541009464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541009465	Nuclease-related domain; Region: NERD; pfam08378
999541009466	Transmembrane protein 55A; Region: Tmemb_55A; pfam09788
999541009467	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
999541009468	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
999541009469	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
999541009470	DNA topoisomerase III; Provisional; Region: PRK07726
999541009471	active site
999541009472	putative interdomain interaction site [polypeptide binding]; other site
999541009473	putative metal-binding site [ion binding]; other site
999541009474	putative nucleotide binding site [chemical binding]; other site
999541009475	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
999541009476	domain I; other site
999541009477	DNA binding groove [nucleotide binding]
999541009478	phosphate binding site [ion binding]; other site
999541009479	domain II; other site
999541009480	domain III; other site
999541009481	nucleotide binding site [chemical binding]; other site
999541009482	catalytic site [active]
999541009483	domain IV; other site
999541009484	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
999541009485	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
999541009486	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
999541009487	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
999541009488	tandem repeat interface [polypeptide binding]; other site
999541009489	oligomer interface [polypeptide binding]; other site
999541009490	active site residues [active]
999541009491	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541009492	Sel1-like repeats; Region: SEL1; smart00671
999541009493	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
999541009494	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
999541009495	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
999541009496	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
999541009497	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
999541009498	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
999541009499	RES domain; Region: RES; pfam08808
999541009500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541009501	MoxR-like ATPases [General function prediction only]; Region: COG0714
999541009502	Walker A motif; other site
999541009503	ATP binding site [chemical binding]; other site
999541009504	Walker B motif; other site
999541009505	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14877
999541009506	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
999541009507	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
999541009508	TraU protein; Region: TraU; pfam06834
999541009509	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
999541009510	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
999541009511	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
999541009512	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
999541009513	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
999541009514	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
999541009515	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
999541009516	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
999541009517	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
999541009518	TraK protein; Region: TraK; pfam06586
999541009519	TraE protein; Region: TraE; cl05060
999541009520	TraL protein; Region: TraL; cl06278
999541009521	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541009522	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541009523	ligand binding site [chemical binding]; other site
999541009524	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541009525	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541009526	Type II/IV secretion system protein; Region: T2SE; pfam00437
999541009527	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541009528	Walker A motif; other site
999541009529	ATP binding site [chemical binding]; other site
999541009530	Walker B motif; other site
999541009531	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541009532	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541009533	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541009534	catalytic residue [active]
999541009535	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
999541009536	F plasmid transfer operon protein; Region: TraF; pfam13728
999541009537	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
999541009538	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
999541009539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
999541009540	non-specific DNA binding site [nucleotide binding]; other site
999541009541	salt bridge; other site
999541009542	sequence-specific DNA binding site [nucleotide binding]; other site
999541009543	H-NS histone family; Region: Histone_HNS; pfam00816
999541009544	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541009545	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
999541009546	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
999541009547	AAA-like domain; Region: AAA_10; pfam12846
999541009548	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541009549	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
999541009550	DNA binding residues [nucleotide binding]
999541009551	dimerization interface [polypeptide binding]; other site
999541009552	Domain of unknown function DUF29; Region: DUF29; pfam01724
999541009553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541009554	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541009555	Walker A motif; other site
999541009556	ATP binding site [chemical binding]; other site
999541009557	Walker B motif; other site
999541009558	arginine finger; other site
999541009559	HD domain; Region: HD_4; pfam13328
999541009560	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
999541009561	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
999541009562	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
999541009563	Mrr N-terminal domain; Region: Mrr_N; pfam14338
999541009564	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
999541009565	DNA methylase; Region: N6_N4_Mtase; pfam01555
999541009566	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
999541009567	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
999541009568	cofactor binding site; other site
999541009569	DNA binding site [nucleotide binding]
999541009570	substrate interaction site [chemical binding]; other site
999541009571	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
999541009572	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
999541009573	plasmid segregation protein ParM; Provisional; Region: PRK13917
999541009574	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
999541009575	Mg binding site [ion binding]; other site
999541009576	nucleotide binding site [chemical binding]; other site
999541009577	putative protofilament interface [polypeptide binding]; other site
999541009578	DnaA N-terminal domain; Region: DnaA_N; pfam11638
999541009579	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
999541009580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541009581	Walker A motif; other site
999541009582	ATP binding site [chemical binding]; other site
999541009583	Walker B motif; other site
999541009584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
999541009585	arginine finger; other site
999541009586	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
999541009587	DnaA box-binding interface [nucleotide binding]; other site
999541009588	DNA polymerase III subunit beta; Validated; Region: PRK05643
999541009589	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
999541009590	putative DNA binding surface [nucleotide binding]; other site
999541009591	dimer interface [polypeptide binding]; other site
999541009592	beta-clamp/clamp loader binding surface; other site
999541009593	beta-clamp/translesion DNA polymerase binding surface; other site
999541009594	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
999541009595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009596	ATP binding site [chemical binding]; other site
999541009597	Mg2+ binding site [ion binding]; other site
999541009598	G-X-G motif; other site
999541009599	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
999541009600	anchoring element; other site
999541009601	dimer interface [polypeptide binding]; other site
999541009602	ATP binding site [chemical binding]; other site
999541009603	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
999541009604	active site
999541009605	putative metal-binding site [ion binding]; other site
999541009606	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
999541009607	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
999541009608	ParB-like nuclease domain; Region: ParB; smart00470
999541009609	RepB plasmid partitioning protein; Region: RepB; pfam07506
999541009610	ParB-like nuclease domain; Region: ParBc; pfam02195
999541009611	RepB plasmid partitioning protein; Region: RepB; pfam07506
999541009612	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
999541009613	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
999541009614	catalytic residues [active]
999541009615	catalytic nucleophile [active]
999541009616	Recombinase; Region: Recombinase; pfam07508
999541009617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
999541009618	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
999541009619	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
999541009620	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
999541009621	transcriptional regulator RcsB; Provisional; Region: PRK10840
999541009622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009623	active site
999541009624	phosphorylation site [posttranslational modification]
999541009625	intermolecular recognition site; other site
999541009626	dimerization interface [polypeptide binding]; other site
999541009627	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541009628	dimerization interface [polypeptide binding]; other site
999541009629	DNA binding residues [nucleotide binding]
999541009630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541009631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009632	active site
999541009633	phosphorylation site [posttranslational modification]
999541009634	intermolecular recognition site; other site
999541009635	dimerization interface [polypeptide binding]; other site
999541009636	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541009637	DNA binding residues [nucleotide binding]
999541009638	dimerization interface [polypeptide binding]; other site
999541009639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541009640	dimer interface [polypeptide binding]; other site
999541009641	phosphorylation site [posttranslational modification]
999541009642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009643	ATP binding site [chemical binding]; other site
999541009644	Mg2+ binding site [ion binding]; other site
999541009645	G-X-G motif; other site
999541009646	Response regulator receiver domain; Region: Response_reg; pfam00072
999541009647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009648	active site
999541009649	phosphorylation site [posttranslational modification]
999541009650	intermolecular recognition site; other site
999541009651	dimerization interface [polypeptide binding]; other site
999541009652	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541009653	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
999541009654	putative heme binding pocket [chemical binding]; other site
999541009655	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
999541009656	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541009657	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541009658	DNA binding residues [nucleotide binding]
999541009659	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
999541009660	Restriction endonuclease [Defense mechanisms]; Region: COG3587
999541009661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541009662	ATP binding site [chemical binding]; other site
999541009663	putative Mg++ binding site [ion binding]; other site
999541009664	DNA methylase; Region: N6_N4_Mtase; cl17433
999541009665	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
999541009666	DNA methylase; Region: N6_N4_Mtase; pfam01555
999541009667	DNA methylase; Region: N6_N4_Mtase; cl17433
999541009668	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
999541009669	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
999541009670	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
999541009671	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
999541009672	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
999541009673	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
999541009674	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
999541009675	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
999541009676	LrgB-like family; Region: LrgB; cl00596
999541009677	LrgA family; Region: LrgA; pfam03788
999541009678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541009679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541009680	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
999541009681	putative dimerization interface [polypeptide binding]; other site
999541009682	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541009683	MarR family; Region: MarR_2; cl17246
999541009684	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541009685	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
999541009686	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
999541009687	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
999541009688	GspL periplasmic domain; Region: GspL_C; pfam12693
999541009689	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
999541009690	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
999541009691	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
999541009692	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
999541009693	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
999541009694	Type II transport protein GspH; Region: GspH; pfam12019
999541009695	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
999541009696	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541009697	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
999541009698	type II secretion system protein F; Region: GspF; TIGR02120
999541009699	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541009700	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541009701	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
999541009702	type II secretion system protein E; Region: type_II_gspE; TIGR02533
999541009703	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
999541009704	Walker A motif; other site
999541009705	ATP binding site [chemical binding]; other site
999541009706	Walker B motif; other site
999541009707	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541009708	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541009709	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541009710	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
999541009711	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541009712	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541009713	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541009714	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541009715	catalytic residue [active]
999541009716	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
999541009717	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
999541009718	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
999541009719	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
999541009720	IHF dimer interface [polypeptide binding]; other site
999541009721	IHF - DNA interface [nucleotide binding]; other site
999541009722	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
999541009723	Uncharacterized conserved protein [Function unknown]; Region: COG4121
999541009724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541009725	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
999541009726	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
999541009727	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541009728	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541009729	putative DNA binding site [nucleotide binding]; other site
999541009730	putative Zn2+ binding site [ion binding]; other site
999541009731	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
999541009732	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
999541009733	catalytic triad [active]
999541009734	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541009735	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
999541009736	active site
999541009737	FMN binding site [chemical binding]; other site
999541009738	substrate binding site [chemical binding]; other site
999541009739	homotetramer interface [polypeptide binding]; other site
999541009740	catalytic residue [active]
999541009741	Proteins containing SET domain [General function prediction only]; Region: COG2940
999541009742	SET domain; Region: SET; pfam00856
999541009743	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
999541009744	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541009745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541009746	dimer interface [polypeptide binding]; other site
999541009747	phosphorylation site [posttranslational modification]
999541009748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541009749	ATP binding site [chemical binding]; other site
999541009750	Mg2+ binding site [ion binding]; other site
999541009751	G-X-G motif; other site
999541009752	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541009753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541009754	active site
999541009755	phosphorylation site [posttranslational modification]
999541009756	intermolecular recognition site; other site
999541009757	dimerization interface [polypeptide binding]; other site
999541009758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541009759	DNA binding site [nucleotide binding]
999541009760	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
999541009761	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
999541009762	aromatic arch; other site
999541009763	DCoH dimer interaction site [polypeptide binding]; other site
999541009764	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
999541009765	DCoH tetramer interaction site [polypeptide binding]; other site
999541009766	substrate binding site [chemical binding]; other site
999541009767	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
999541009768	cofactor binding site; other site
999541009769	metal binding site [ion binding]; metal-binding site
999541009770	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541009771	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
999541009772	AsnC family; Region: AsnC_trans_reg; pfam01037
999541009773	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
999541009774	putative active site [active]
999541009775	signature motif; other site
999541009776	putative metal binding residues [ion binding]; other site
999541009777	putative triphosphate binding site [ion binding]; other site
999541009778	dimer interface [polypeptide binding]; other site
999541009779	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541009780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541009781	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541009782	dimerization interface [polypeptide binding]; other site
999541009783	choline dehydrogenase; Validated; Region: PRK02106
999541009784	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541009785	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541009786	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541009787	Walker A/P-loop; other site
999541009788	ATP binding site [chemical binding]; other site
999541009789	Q-loop/lid; other site
999541009790	ABC transporter signature motif; other site
999541009791	Walker B; other site
999541009792	D-loop; other site
999541009793	H-loop/switch region; other site
999541009794	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541009795	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541009796	Walker A/P-loop; other site
999541009797	ATP binding site [chemical binding]; other site
999541009798	Q-loop/lid; other site
999541009799	ABC transporter signature motif; other site
999541009800	Walker B; other site
999541009801	D-loop; other site
999541009802	H-loop/switch region; other site
999541009803	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
999541009804	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
999541009805	putative ligand binding site [chemical binding]; other site
999541009806	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541009807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541009808	TM-ABC transporter signature motif; other site
999541009809	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541009810	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541009811	TM-ABC transporter signature motif; other site
999541009812	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541009813	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
999541009814	putative ligand binding site [chemical binding]; other site
999541009815	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541009816	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
999541009817	putative ligand binding site [chemical binding]; other site
999541009818	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541009819	TM-ABC transporter signature motif; other site
999541009820	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541009821	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541009822	TM-ABC transporter signature motif; other site
999541009823	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541009824	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541009825	Walker A/P-loop; other site
999541009826	ATP binding site [chemical binding]; other site
999541009827	Q-loop/lid; other site
999541009828	ABC transporter signature motif; other site
999541009829	Walker B; other site
999541009830	D-loop; other site
999541009831	H-loop/switch region; other site
999541009832	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541009833	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541009834	Walker A/P-loop; other site
999541009835	ATP binding site [chemical binding]; other site
999541009836	Q-loop/lid; other site
999541009837	ABC transporter signature motif; other site
999541009838	Walker B; other site
999541009839	D-loop; other site
999541009840	H-loop/switch region; other site
999541009841	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
999541009842	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
999541009843	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
999541009844	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
999541009845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541009846	S-adenosylmethionine binding site [chemical binding]; other site
999541009847	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
999541009848	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009849	P-loop; other site
999541009850	Magnesium ion binding site [ion binding]; other site
999541009851	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541009852	Magnesium ion binding site [ion binding]; other site
999541009853	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
999541009854	ParB-like nuclease domain; Region: ParBc; pfam02195
999541009855	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
999541009856	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
999541009857	transmembrane helices; other site
999541009858	ATP synthase I chain; Region: ATP_synt_I; pfam03899
999541009859	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
999541009860	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
999541009861	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
999541009862	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
999541009863	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
999541009864	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
999541009865	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
999541009866	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
999541009867	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
999541009868	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
999541009869	beta subunit interaction interface [polypeptide binding]; other site
999541009870	Walker A motif; other site
999541009871	ATP binding site [chemical binding]; other site
999541009872	Walker B motif; other site
999541009873	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
999541009874	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
999541009875	core domain interface [polypeptide binding]; other site
999541009876	delta subunit interface [polypeptide binding]; other site
999541009877	epsilon subunit interface [polypeptide binding]; other site
999541009878	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
999541009879	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
999541009880	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
999541009881	alpha subunit interaction interface [polypeptide binding]; other site
999541009882	Walker A motif; other site
999541009883	ATP binding site [chemical binding]; other site
999541009884	Walker B motif; other site
999541009885	inhibitor binding site; inhibition site
999541009886	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
999541009887	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
999541009888	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
999541009889	gamma subunit interface [polypeptide binding]; other site
999541009890	epsilon subunit interface [polypeptide binding]; other site
999541009891	LBP interface [polypeptide binding]; other site
999541009892	AMP-binding domain protein; Validated; Region: PRK08315
999541009893	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541009894	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
999541009895	acyl-activating enzyme (AAE) consensus motif; other site
999541009896	putative AMP binding site [chemical binding]; other site
999541009897	putative active site [active]
999541009898	putative CoA binding site [chemical binding]; other site
999541009899	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541009900	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541009901	substrate binding pocket [chemical binding]; other site
999541009902	membrane-bound complex binding site; other site
999541009903	hinge residues; other site
999541009904	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
999541009905	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
999541009906	substrate binding site [chemical binding]; other site
999541009907	active site
999541009908	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
999541009909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541009910	ATP binding site [chemical binding]; other site
999541009911	putative Mg++ binding site [ion binding]; other site
999541009912	helicase superfamily c-terminal domain; Region: HELICc; smart00490
999541009913	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
999541009914	Predicted transcriptional regulator [Transcription]; Region: COG3905
999541009915	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
999541009916	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
999541009917	Glutamate binding site [chemical binding]; other site
999541009918	NAD binding site [chemical binding]; other site
999541009919	catalytic residues [active]
999541009920	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541009921	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541009922	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541009923	dimerization interface [polypeptide binding]; other site
999541009924	ligand binding site [chemical binding]; other site
999541009925	putative aminotransferase; Provisional; Region: PRK12414
999541009926	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541009927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541009928	homodimer interface [polypeptide binding]; other site
999541009929	catalytic residue [active]
999541009930	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
999541009931	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541009932	substrate binding pocket [chemical binding]; other site
999541009933	membrane-bound complex binding site; other site
999541009934	hinge residues; other site
999541009935	Predicted transcriptional regulators [Transcription]; Region: COG1695
999541009936	Transcriptional regulator PadR-like family; Region: PadR; cl17335
999541009937	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
999541009938	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
999541009939	DNA binding residues [nucleotide binding]
999541009940	dimer interface [polypeptide binding]; other site
999541009941	putative metal binding site [ion binding]; other site
999541009942	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
999541009943	Heavy-metal-associated domain; Region: HMA; pfam00403
999541009944	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
999541009945	Soluble P-type ATPase [General function prediction only]; Region: COG4087
999541009946	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
999541009947	ethanolamine permease; Region: 2A0305; TIGR00908
999541009948	hypothetical protein; Provisional; Region: PHA02764
999541009949	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
999541009950	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
999541009951	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
999541009952	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
999541009953	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541009954	NAD(P) binding site [chemical binding]; other site
999541009955	catalytic residues [active]
999541009956	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541009957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541009958	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541009959	thiamine pyrophosphate protein; Validated; Region: PRK08199
999541009960	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541009961	PYR/PP interface [polypeptide binding]; other site
999541009962	dimer interface [polypeptide binding]; other site
999541009963	TPP binding site [chemical binding]; other site
999541009964	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541009965	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
999541009966	TPP-binding site [chemical binding]; other site
999541009967	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
999541009968	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
999541009969	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
999541009970	Alginate lyase; Region: Alginate_lyase; pfam05426
999541009971	glycine dehydrogenase; Provisional; Region: PRK05367
999541009972	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541009973	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541009974	catalytic residue [active]
999541009975	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
999541009976	tetramer interface [polypeptide binding]; other site
999541009977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541009978	catalytic residue [active]
999541009979	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
999541009980	lipoyl attachment site [posttranslational modification]; other site
999541009981	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
999541009982	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
999541009983	putative oxidoreductase; Provisional; Region: PRK11579
999541009984	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541009985	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
999541009986	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
999541009987	Part of AAA domain; Region: AAA_19; pfam13245
999541009988	Family description; Region: UvrD_C_2; pfam13538
999541009989	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
999541009990	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541009991	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
999541009992	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541009993	active site
999541009994	DNA binding site [nucleotide binding]
999541009995	Int/Topo IB signature motif; other site
999541009996	DNA primase domain-containing protein; Region: PHA02415
999541009997	CHC2 zinc finger; Region: zf-CHC2; cl17510
999541009998	Toprim domain; Region: Toprim_3; pfam13362
999541009999	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
999541010000	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
999541010001	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541010002	non-specific DNA binding site [nucleotide binding]; other site
999541010003	salt bridge; other site
999541010004	sequence-specific DNA binding site [nucleotide binding]; other site
999541010005	tail protein; Provisional; Region: D; PHA02561
999541010006	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
999541010007	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
999541010008	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
999541010009	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
999541010010	major tail tube protein; Provisional; Region: FII; PHA02600
999541010011	major tail sheath protein; Provisional; Region: FI; PHA02560
999541010012	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
999541010013	Phage Tail Collar Domain; Region: Collar; pfam07484
999541010014	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
999541010015	Baseplate J-like protein; Region: Baseplate_J; cl01294
999541010016	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
999541010017	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
999541010018	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
999541010019	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
999541010020	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
999541010021	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
999541010022	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
999541010023	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
999541010024	Protein of unknown function (DUF754); Region: DUF754; pfam05449
999541010025	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
999541010026	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
999541010027	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
999541010028	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
999541010029	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
999541010030	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
999541010031	Immunoglobulin domain; Region: Ig; cl11960
999541010032	Immunoglobulin domain; Region: Ig_2; pfam13895
999541010033	Immunoglobulin I-set domain; Region: I-set; pfam07679
999541010034	Immunoglobulin I-set domain; Region: I-set; pfam07679
999541010035	Immunoglobulin domain; Region: Ig; cd00096
999541010036	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
999541010037	sugar binding site [chemical binding]; other site
999541010038	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
999541010039	Immunoglobulin I-set domain; Region: I-set; pfam07679
999541010040	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
999541010041	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
999541010042	sugar binding site [chemical binding]; other site
999541010043	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
999541010044	sugar binding site [chemical binding]; other site
999541010045	glycosyl hydrolase 64 family; Region: GH64-like; cd09214
999541010046	substrate binding pocket [chemical binding]; other site
999541010047	catalytic residues [active]
999541010048	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
999541010049	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541010050	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
999541010051	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541010052	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541010053	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
999541010054	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
999541010055	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
999541010056	Walker A motif; other site
999541010057	ATP binding site [chemical binding]; other site
999541010058	Walker B motif; other site
999541010059	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
999541010060	Tetratricopeptide repeat; Region: TPR_16; pfam13432
999541010061	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
999541010062	Secretin and TonB N terminus short domain; Region: STN; smart00965
999541010063	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541010064	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541010065	Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546
999541010066	dockerin binding interface; other site
999541010067	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
999541010068	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
999541010069	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541010070	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
999541010071	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
999541010072	active site
999541010073	SUMO-1 interface [polypeptide binding]; other site
999541010074	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541010075	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
999541010076	HAMP domain; Region: HAMP; pfam00672
999541010077	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541010078	dimer interface [polypeptide binding]; other site
999541010079	putative CheW interface [polypeptide binding]; other site
999541010080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541010081	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541010082	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541010083	active site
999541010084	catalytic tetrad [active]
999541010085	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
999541010086	Predicted amidohydrolase [General function prediction only]; Region: COG0388
999541010087	putative active site [active]
999541010088	catalytic triad [active]
999541010089	putative dimer interface [polypeptide binding]; other site
999541010090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541010091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541010092	dimerization interface [polypeptide binding]; other site
999541010093	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
999541010094	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
999541010095	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541010096	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
999541010097	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541010098	[2Fe-2S] cluster binding site [ion binding]; other site
999541010099	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
999541010100	alpha subunit interface [polypeptide binding]; other site
999541010101	active site
999541010102	substrate binding site [chemical binding]; other site
999541010103	Fe binding site [ion binding]; other site
999541010104	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
999541010105	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
999541010106	putative trimer interface [polypeptide binding]; other site
999541010107	putative CoA binding site [chemical binding]; other site
999541010108	short chain dehydrogenase; Provisional; Region: PRK05875
999541010109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541010110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541010111	active site
999541010112	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
999541010113	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
999541010114	dimer interface [polypeptide binding]; other site
999541010115	active site
999541010116	CoA binding pocket [chemical binding]; other site
999541010117	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
999541010118	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
999541010119	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
999541010120	dimer interface [polypeptide binding]; other site
999541010121	active site
999541010122	CoA binding pocket [chemical binding]; other site
999541010123	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
999541010124	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
999541010125	inhibitor-cofactor binding pocket; inhibition site
999541010126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541010127	catalytic residue [active]
999541010128	Tetratricopeptide repeat; Region: TPR_16; pfam13432
999541010129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541010130	TPR motif; other site
999541010131	binding surface
999541010132	TPR repeat; Region: TPR_11; pfam13414
999541010133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541010134	binding surface
999541010135	TPR motif; other site
999541010136	TPR repeat; Region: TPR_11; pfam13414
999541010137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541010138	TPR motif; other site
999541010139	binding surface
999541010140	Flagellar protein FliT; Region: FliT; pfam05400
999541010141	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
999541010142	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
999541010143	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
999541010144	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
999541010145	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
999541010146	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
999541010147	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
999541010148	putative hydrolase; Provisional; Region: PRK10976
999541010149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541010150	active site
999541010151	motif I; other site
999541010152	motif II; other site
999541010153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
999541010154	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
999541010155	H-NS histone family; Region: Histone_HNS; pfam00816
999541010156	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541010157	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541010158	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
999541010159	putative ADP-binding pocket [chemical binding]; other site
999541010160	transcriptional activator FlhD; Provisional; Region: PRK02909
999541010161	transcriptional activator FlhC; Provisional; Region: PRK12722
999541010162	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
999541010163	flagellar motor protein MotA; Validated; Region: PRK09110
999541010164	flagellar motor protein MotB; Validated; Region: motB; PRK09041
999541010165	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
999541010166	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541010167	ligand binding site [chemical binding]; other site
999541010168	Response regulator receiver domain; Region: Response_reg; pfam00072
999541010169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541010170	active site
999541010171	phosphorylation site [posttranslational modification]
999541010172	intermolecular recognition site; other site
999541010173	dimerization interface [polypeptide binding]; other site
999541010174	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
999541010175	putative binding surface; other site
999541010176	active site
999541010177	CheY binding; Region: CheY-binding; pfam09078
999541010178	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
999541010179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541010180	ATP binding site [chemical binding]; other site
999541010181	Mg2+ binding site [ion binding]; other site
999541010182	G-X-G motif; other site
999541010183	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
999541010184	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
999541010185	putative CheA interaction surface; other site
999541010186	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
999541010187	dimer interface [polypeptide binding]; other site
999541010188	ligand binding site [chemical binding]; other site
999541010189	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
999541010190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541010191	dimerization interface [polypeptide binding]; other site
999541010192	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541010193	dimer interface [polypeptide binding]; other site
999541010194	putative CheW interface [polypeptide binding]; other site
999541010195	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
999541010196	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
999541010197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541010198	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489
999541010199	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
999541010200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541010201	active site
999541010202	phosphorylation site [posttranslational modification]
999541010203	intermolecular recognition site; other site
999541010204	dimerization interface [polypeptide binding]; other site
999541010205	CheB methylesterase; Region: CheB_methylest; pfam01339
999541010206	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
999541010207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541010208	active site
999541010209	phosphorylation site [posttranslational modification]
999541010210	intermolecular recognition site; other site
999541010211	dimerization interface [polypeptide binding]; other site
999541010212	chemotaxis regulator CheZ; Provisional; Region: PRK11166
999541010213	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
999541010214	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
999541010215	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
999541010216	dimer interface [polypeptide binding]; other site
999541010217	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
999541010218	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
999541010219	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
999541010220	FHIPEP family; Region: FHIPEP; pfam00771
999541010221	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722
999541010222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541010223	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541010224	Walker A/P-loop; other site
999541010225	ATP binding site [chemical binding]; other site
999541010226	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541010227	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
999541010228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541010229	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
999541010230	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541010231	DNA binding residues [nucleotide binding]
999541010232	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
999541010233	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
999541010234	homotetramer interface [polypeptide binding]; other site
999541010235	ligand binding site [chemical binding]; other site
999541010236	catalytic site [active]
999541010237	NAD binding site [chemical binding]; other site
999541010238	Predicted membrane protein [Function unknown]; Region: COG1950
999541010239	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
999541010240	FAD binding site [chemical binding]; other site
999541010241	Dienelactone hydrolase family; Region: DLH; pfam01738
999541010242	Nitronate monooxygenase; Region: NMO; pfam03060
999541010243	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
999541010244	FMN binding site [chemical binding]; other site
999541010245	substrate binding site [chemical binding]; other site
999541010246	putative catalytic residue [active]
999541010247	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541010248	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541010249	dimerization interface [polypeptide binding]; other site
999541010250	ligand binding site [chemical binding]; other site
999541010251	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
999541010252	H-NS histone family; Region: Histone_HNS; pfam00816
999541010253	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541010254	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
999541010255	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
999541010256	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541010257	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541010258	putative DNA binding site [nucleotide binding]; other site
999541010259	putative Zn2+ binding site [ion binding]; other site
999541010260	AsnC family; Region: AsnC_trans_reg; pfam01037
999541010261	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
999541010262	active site
999541010263	substrate binding site [chemical binding]; other site
999541010264	catalytic site [active]
999541010265	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
999541010266	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
999541010267	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
999541010268	Predicted methyltransferases [General function prediction only]; Region: COG0313
999541010269	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
999541010270	putative SAM binding site [chemical binding]; other site
999541010271	putative homodimer interface [polypeptide binding]; other site
999541010272	hypothetical protein; Provisional; Region: PRK14673
999541010273	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
999541010274	active site
999541010275	dimer interface [polypeptide binding]; other site
999541010276	outer membrane lipoprotein; Provisional; Region: PRK11023
999541010277	BON domain; Region: BON; pfam04972
999541010278	Cytochrome c; Region: Cytochrom_C; cl11414
999541010279	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
999541010280	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
999541010281	putative transposase OrfB; Reviewed; Region: PHA02517
999541010282	Integrase core domain; Region: rve; pfam00665
999541010283	Integrase core domain; Region: rve_3; pfam13683
999541010284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541010285	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541010286	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541010287	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541010288	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541010289	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541010290	RES domain; Region: RES; pfam08808
999541010291	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541010292	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541010293	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541010294	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541010295	HTH-like domain; Region: HTH_21; pfam13276
999541010296	Integrase core domain; Region: rve; pfam00665
999541010297	Integrase core domain; Region: rve_3; pfam13683
999541010298	Transposase; Region: HTH_Tnp_1; pfam01527
999541010299	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
999541010300	active site
999541010301	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
999541010302	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541010303	N-terminal plug; other site
999541010304	ligand-binding site [chemical binding]; other site
999541010305	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
999541010306	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
999541010307	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
999541010308	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
999541010309	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
999541010310	intersubunit interface [polypeptide binding]; other site
999541010311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541010312	Response regulator receiver domain; Region: Response_reg; pfam00072
999541010313	active site
999541010314	phosphorylation site [posttranslational modification]
999541010315	intermolecular recognition site; other site
999541010316	dimerization interface [polypeptide binding]; other site
999541010317	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541010318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541010319	metal binding site [ion binding]; metal-binding site
999541010320	active site
999541010321	I-site; other site
999541010322	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
999541010323	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541010324	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541010325	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541010326	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
999541010327	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
999541010328	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
999541010329	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
999541010330	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
999541010331	substrate binding site [chemical binding]; other site
999541010332	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541010333	active site
999541010334	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
999541010335	Malic enzyme, N-terminal domain; Region: malic; pfam00390
999541010336	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
999541010337	putative NAD(P) binding site [chemical binding]; other site
999541010338	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
999541010339	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
999541010340	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
999541010341	dimer interface [polypeptide binding]; other site
999541010342	PYR/PP interface [polypeptide binding]; other site
999541010343	TPP binding site [chemical binding]; other site
999541010344	substrate binding site [chemical binding]; other site
999541010345	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
999541010346	TPP-binding site; other site
999541010347	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
999541010348	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
999541010349	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
999541010350	dimer interface [polypeptide binding]; other site
999541010351	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
999541010352	active site
999541010353	Fe binding site [ion binding]; other site
999541010354	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541010355	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541010356	putative DNA binding site [nucleotide binding]; other site
999541010357	putative Zn2+ binding site [ion binding]; other site
999541010358	AsnC family; Region: AsnC_trans_reg; pfam01037
999541010359	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541010360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541010361	Coenzyme A binding pocket [chemical binding]; other site
999541010362	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541010363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541010364	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
999541010365	Protein of unknown function; Region: DUF3658; pfam12395
999541010366	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
999541010367	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
999541010368	FAD binding pocket [chemical binding]; other site
999541010369	FAD binding motif [chemical binding]; other site
999541010370	phosphate binding motif [ion binding]; other site
999541010371	beta-alpha-beta structure motif; other site
999541010372	NAD(p) ribose binding residues [chemical binding]; other site
999541010373	NAD binding pocket [chemical binding]; other site
999541010374	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
999541010375	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541010376	catalytic loop [active]
999541010377	iron binding site [ion binding]; other site
999541010378	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
999541010379	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
999541010380	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
999541010381	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
999541010382	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
999541010383	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
999541010384	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
999541010385	active site
999541010386	catalytic triad [active]
999541010387	oxyanion hole [active]
999541010388	elongation factor Tu; Reviewed; Region: PRK00049
999541010389	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
999541010390	G1 box; other site
999541010391	GEF interaction site [polypeptide binding]; other site
999541010392	GTP/Mg2+ binding site [chemical binding]; other site
999541010393	Switch I region; other site
999541010394	G2 box; other site
999541010395	G3 box; other site
999541010396	Switch II region; other site
999541010397	G4 box; other site
999541010398	G5 box; other site
999541010399	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
999541010400	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
999541010401	Antibiotic Binding Site [chemical binding]; other site
999541010402	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
999541010403	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
999541010404	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
999541010405	putative homodimer interface [polypeptide binding]; other site
999541010406	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
999541010407	heterodimer interface [polypeptide binding]; other site
999541010408	homodimer interface [polypeptide binding]; other site
999541010409	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
999541010410	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
999541010411	23S rRNA interface [nucleotide binding]; other site
999541010412	L7/L12 interface [polypeptide binding]; other site
999541010413	putative thiostrepton binding site; other site
999541010414	L25 interface [polypeptide binding]; other site
999541010415	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
999541010416	mRNA/rRNA interface [nucleotide binding]; other site
999541010417	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
999541010418	23S rRNA interface [nucleotide binding]; other site
999541010419	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
999541010420	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
999541010421	peripheral dimer interface [polypeptide binding]; other site
999541010422	core dimer interface [polypeptide binding]; other site
999541010423	L10 interface [polypeptide binding]; other site
999541010424	L11 interface [polypeptide binding]; other site
999541010425	putative EF-Tu interaction site [polypeptide binding]; other site
999541010426	putative EF-G interaction site [polypeptide binding]; other site
999541010427	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
999541010428	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
999541010429	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
999541010430	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
999541010431	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
999541010432	RPB3 interaction site [polypeptide binding]; other site
999541010433	RPB1 interaction site [polypeptide binding]; other site
999541010434	RPB11 interaction site [polypeptide binding]; other site
999541010435	RPB10 interaction site [polypeptide binding]; other site
999541010436	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
999541010437	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
999541010438	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
999541010439	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
999541010440	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
999541010441	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
999541010442	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
999541010443	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
999541010444	DNA binding site [nucleotide binding]
999541010445	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
999541010446	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541010447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541010448	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541010449	dimerization interface [polypeptide binding]; other site
999541010450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541010451	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541010452	putative substrate translocation pore; other site
999541010453	allantoate amidohydrolase; Reviewed; Region: PRK12893
999541010454	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
999541010455	active site
999541010456	metal binding site [ion binding]; metal-binding site
999541010457	dimer interface [polypeptide binding]; other site
999541010458	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
999541010459	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
999541010460	active site
999541010461	Zn binding site [ion binding]; other site
999541010462	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541010463	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541010464	trimer interface [polypeptide binding]; other site
999541010465	eyelet of channel; other site
999541010466	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541010467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541010468	aldolase II superfamily protein; Provisional; Region: PRK07044
999541010469	intersubunit interface [polypeptide binding]; other site
999541010470	active site
999541010471	Zn2+ binding site [ion binding]; other site
999541010472	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
999541010473	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
999541010474	putative ligand binding site [chemical binding]; other site
999541010475	NAD binding site [chemical binding]; other site
999541010476	dimerization interface [polypeptide binding]; other site
999541010477	catalytic site [active]
999541010478	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541010479	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541010480	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541010481	dimerization interface [polypeptide binding]; other site
999541010482	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
999541010483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541010484	ATP binding site [chemical binding]; other site
999541010485	putative Mg++ binding site [ion binding]; other site
999541010486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541010487	nucleotide binding region [chemical binding]; other site
999541010488	ATP-binding site [chemical binding]; other site
999541010489	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
999541010490	HRDC domain; Region: HRDC; pfam00570
999541010491	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
999541010492	S17 interaction site [polypeptide binding]; other site
999541010493	S8 interaction site; other site
999541010494	16S rRNA interaction site [nucleotide binding]; other site
999541010495	streptomycin interaction site [chemical binding]; other site
999541010496	23S rRNA interaction site [nucleotide binding]; other site
999541010497	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
999541010498	30S ribosomal protein S7; Validated; Region: PRK05302
999541010499	elongation factor G; Reviewed; Region: PRK00007
999541010500	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
999541010501	G1 box; other site
999541010502	putative GEF interaction site [polypeptide binding]; other site
999541010503	GTP/Mg2+ binding site [chemical binding]; other site
999541010504	Switch I region; other site
999541010505	G2 box; other site
999541010506	G3 box; other site
999541010507	Switch II region; other site
999541010508	G4 box; other site
999541010509	G5 box; other site
999541010510	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
999541010511	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
999541010512	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
999541010513	elongation factor Tu; Reviewed; Region: PRK00049
999541010514	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
999541010515	G1 box; other site
999541010516	GEF interaction site [polypeptide binding]; other site
999541010517	GTP/Mg2+ binding site [chemical binding]; other site
999541010518	Switch I region; other site
999541010519	G2 box; other site
999541010520	G3 box; other site
999541010521	Switch II region; other site
999541010522	G4 box; other site
999541010523	G5 box; other site
999541010524	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
999541010525	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
999541010526	Antibiotic Binding Site [chemical binding]; other site
999541010527	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
999541010528	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
999541010529	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
999541010530	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
999541010531	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
999541010532	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
999541010533	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
999541010534	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
999541010535	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
999541010536	putative translocon binding site; other site
999541010537	protein-rRNA interface [nucleotide binding]; other site
999541010538	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
999541010539	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
999541010540	G-X-X-G motif; other site
999541010541	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
999541010542	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
999541010543	23S rRNA interface [nucleotide binding]; other site
999541010544	5S rRNA interface [nucleotide binding]; other site
999541010545	putative antibiotic binding site [chemical binding]; other site
999541010546	L25 interface [polypeptide binding]; other site
999541010547	L27 interface [polypeptide binding]; other site
999541010548	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
999541010549	23S rRNA interface [nucleotide binding]; other site
999541010550	putative translocon interaction site; other site
999541010551	signal recognition particle (SRP54) interaction site; other site
999541010552	L23 interface [polypeptide binding]; other site
999541010553	trigger factor interaction site; other site
999541010554	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
999541010555	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
999541010556	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
999541010557	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
999541010558	RNA binding site [nucleotide binding]; other site
999541010559	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
999541010560	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
999541010561	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
999541010562	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
999541010563	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
999541010564	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
999541010565	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
999541010566	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
999541010567	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
999541010568	5S rRNA interface [nucleotide binding]; other site
999541010569	L27 interface [polypeptide binding]; other site
999541010570	23S rRNA interface [nucleotide binding]; other site
999541010571	L5 interface [polypeptide binding]; other site
999541010572	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
999541010573	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
999541010574	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
999541010575	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
999541010576	23S rRNA binding site [nucleotide binding]; other site
999541010577	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
999541010578	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
999541010579	SecY translocase; Region: SecY; pfam00344
999541010580	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
999541010581	rRNA binding site [nucleotide binding]; other site
999541010582	predicted 30S ribosome binding site; other site
999541010583	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
999541010584	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
999541010585	30S ribosomal protein S13; Region: bact_S13; TIGR03631
999541010586	30S ribosomal protein S11; Validated; Region: PRK05309
999541010587	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
999541010588	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
999541010589	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541010590	RNA binding surface [nucleotide binding]; other site
999541010591	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
999541010592	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
999541010593	alphaNTD homodimer interface [polypeptide binding]; other site
999541010594	alphaNTD - beta interaction site [polypeptide binding]; other site
999541010595	alphaNTD - beta' interaction site [polypeptide binding]; other site
999541010596	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
999541010597	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
999541010598	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
999541010599	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
999541010600	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
999541010601	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
999541010602	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
999541010603	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541010604	DsbD alpha interface [polypeptide binding]; other site
999541010605	catalytic residues [active]
999541010606	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
999541010607	dimer interface [polypeptide binding]; other site
999541010608	active site
999541010609	aspartate-rich active site metal binding site; other site
999541010610	allosteric magnesium binding site [ion binding]; other site
999541010611	Schiff base residues; other site
999541010612	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
999541010613	G1 box; other site
999541010614	GTP/Mg2+ binding site [chemical binding]; other site
999541010615	Switch I region; other site
999541010616	G2 box; other site
999541010617	G3 box; other site
999541010618	Switch II region; other site
999541010619	G4 box; other site
999541010620	G5 box; other site
999541010621	Cytochrome c553 [Energy production and conversion]; Region: COG2863
999541010622	Cytochrome c; Region: Cytochrom_C; cl11414
999541010623	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
999541010624	ResB-like family; Region: ResB; pfam05140
999541010625	ResB-like family; Region: ResB; pfam05140
999541010626	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
999541010627	TMAO/DMSO reductase; Reviewed; Region: PRK05363
999541010628	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541010629	Moco binding site; other site
999541010630	metal coordination site [ion binding]; other site
999541010631	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
999541010632	diaminopimelate decarboxylase; Region: lysA; TIGR01048
999541010633	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
999541010634	active site
999541010635	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541010636	substrate binding site [chemical binding]; other site
999541010637	catalytic residues [active]
999541010638	dimer interface [polypeptide binding]; other site
999541010639	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
999541010640	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
999541010641	putative iron binding site [ion binding]; other site
999541010642	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
999541010643	Transglycosylase; Region: Transgly; pfam00912
999541010644	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541010645	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
999541010646	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
999541010647	Secretin and TonB N terminus short domain; Region: STN; pfam07660
999541010648	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
999541010649	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541010650	shikimate kinase; Reviewed; Region: aroK; PRK00131
999541010651	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
999541010652	ADP binding site [chemical binding]; other site
999541010653	magnesium binding site [ion binding]; other site
999541010654	putative shikimate binding site; other site
999541010655	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
999541010656	active site
999541010657	dimer interface [polypeptide binding]; other site
999541010658	metal binding site [ion binding]; metal-binding site
999541010659	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
999541010660	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541010661	Zn2+ binding site [ion binding]; other site
999541010662	Mg2+ binding site [ion binding]; other site
999541010663	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
999541010664	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
999541010665	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
999541010666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541010667	dimer interface [polypeptide binding]; other site
999541010668	conserved gate region; other site
999541010669	putative PBP binding loops; other site
999541010670	ABC-ATPase subunit interface; other site
999541010671	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
999541010672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541010673	dimer interface [polypeptide binding]; other site
999541010674	conserved gate region; other site
999541010675	putative PBP binding loops; other site
999541010676	ABC-ATPase subunit interface; other site
999541010677	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
999541010678	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
999541010679	Walker A/P-loop; other site
999541010680	ATP binding site [chemical binding]; other site
999541010681	Q-loop/lid; other site
999541010682	ABC transporter signature motif; other site
999541010683	Walker B; other site
999541010684	D-loop; other site
999541010685	H-loop/switch region; other site
999541010686	TOBE domain; Region: TOBE_2; pfam08402
999541010687	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
999541010688	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
999541010689	putative active site [active]
999541010690	catalytic site [active]
999541010691	putative metal binding site [ion binding]; other site
999541010692	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
999541010693	Transposase IS200 like; Region: Y1_Tnp; cl00848
999541010694	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
999541010695	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
999541010696	active site
999541010697	dimer interface [polypeptide binding]; other site
999541010698	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
999541010699	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
999541010700	active site
999541010701	FMN binding site [chemical binding]; other site
999541010702	substrate binding site [chemical binding]; other site
999541010703	3Fe-4S cluster binding site [ion binding]; other site
999541010704	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
999541010705	domain interface; other site
999541010706	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
999541010707	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541010708	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541010709	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
999541010710	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
999541010711	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
999541010712	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
999541010713	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
999541010714	thiS-thiF/thiG interaction site; other site
999541010715	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
999541010716	ThiS interaction site; other site
999541010717	putative active site [active]
999541010718	tetramer interface [polypeptide binding]; other site
999541010719	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
999541010720	thiamine phosphate binding site [chemical binding]; other site
999541010721	active site
999541010722	pyrophosphate binding site [ion binding]; other site
999541010723	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
999541010724	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
999541010725	Walker A/P-loop; other site
999541010726	ATP binding site [chemical binding]; other site
999541010727	Q-loop/lid; other site
999541010728	ABC transporter signature motif; other site
999541010729	Walker B; other site
999541010730	D-loop; other site
999541010731	H-loop/switch region; other site
999541010732	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
999541010733	Permease; Region: Permease; pfam02405
999541010734	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
999541010735	mce related protein; Region: MCE; pfam02470
999541010736	VacJ like lipoprotein; Region: VacJ; cl01073
999541010737	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
999541010738	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
999541010739	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
999541010740	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
999541010741	Walker A/P-loop; other site
999541010742	ATP binding site [chemical binding]; other site
999541010743	Q-loop/lid; other site
999541010744	ABC transporter signature motif; other site
999541010745	Walker B; other site
999541010746	D-loop; other site
999541010747	H-loop/switch region; other site
999541010748	ABC-2 type transporter; Region: ABC2_membrane; cl17235
999541010749	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
999541010750	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
999541010751	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
999541010752	hinge; other site
999541010753	active site
999541010754	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
999541010755	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
999541010756	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
999541010757	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
999541010758	NAD binding site [chemical binding]; other site
999541010759	dimerization interface [polypeptide binding]; other site
999541010760	product binding site; other site
999541010761	substrate binding site [chemical binding]; other site
999541010762	zinc binding site [ion binding]; other site
999541010763	catalytic residues [active]
999541010764	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
999541010765	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541010766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541010767	homodimer interface [polypeptide binding]; other site
999541010768	catalytic residue [active]
999541010769	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
999541010770	putative active site pocket [active]
999541010771	4-fold oligomerization interface [polypeptide binding]; other site
999541010772	metal binding residues [ion binding]; metal-binding site
999541010773	3-fold/trimer interface [polypeptide binding]; other site
999541010774	MarC family integral membrane protein; Region: MarC; cl00919
999541010775	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
999541010776	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
999541010777	putative active site [active]
999541010778	oxyanion strand; other site
999541010779	catalytic triad [active]
999541010780	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
999541010781	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
999541010782	catalytic residues [active]
999541010783	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
999541010784	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
999541010785	substrate binding site [chemical binding]; other site
999541010786	glutamase interaction surface [polypeptide binding]; other site
999541010787	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
999541010788	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
999541010789	metal binding site [ion binding]; metal-binding site
999541010790	Predicted membrane protein [Function unknown]; Region: COG3671
999541010791	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
999541010792	nucleotide binding site/active site [active]
999541010793	HIT family signature motif; other site
999541010794	catalytic residue [active]
999541010795	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
999541010796	sec-independent translocase; Provisional; Region: tatB; PRK01919
999541010797	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
999541010798	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
999541010799	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541010800	protein binding site [polypeptide binding]; other site
999541010801	Uncharacterized conserved protein [Function unknown]; Region: COG0327
999541010802	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
999541010803	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
999541010804	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
999541010805	[2Fe-2S] cluster binding site [ion binding]; other site
999541010806	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
999541010807	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
999541010808	Qi binding site; other site
999541010809	intrachain domain interface; other site
999541010810	interchain domain interface [polypeptide binding]; other site
999541010811	heme bH binding site [chemical binding]; other site
999541010812	heme bL binding site [chemical binding]; other site
999541010813	Qo binding site; other site
999541010814	interchain domain interface [polypeptide binding]; other site
999541010815	intrachain domain interface; other site
999541010816	Qi binding site; other site
999541010817	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
999541010818	Qo binding site; other site
999541010819	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
999541010820	stringent starvation protein A; Provisional; Region: sspA; PRK09481
999541010821	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
999541010822	C-terminal domain interface [polypeptide binding]; other site
999541010823	putative GSH binding site (G-site) [chemical binding]; other site
999541010824	dimer interface [polypeptide binding]; other site
999541010825	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
999541010826	dimer interface [polypeptide binding]; other site
999541010827	N-terminal domain interface [polypeptide binding]; other site
999541010828	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
999541010829	integrase; Provisional; Region: int; PHA02601
999541010830	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
999541010831	catalytic residues [active]
999541010832	Int/Topo IB signature motif; other site
999541010833	PAAR motif; Region: PAAR_motif; pfam05488
999541010834	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541010835	MULE transposase domain; Region: MULE; pfam10551
999541010836	Predicted membrane protein [Function unknown]; Region: COG4682
999541010837	yiaA/B two helix domain; Region: YiaAB; pfam05360
999541010838	yiaA/B two helix domain; Region: YiaAB; pfam05360
999541010839	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541010840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541010841	metal binding site [ion binding]; metal-binding site
999541010842	active site
999541010843	I-site; other site
999541010844	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
999541010845	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
999541010846	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
999541010847	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
999541010848	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541010849	TPR motif; other site
999541010850	binding surface
999541010851	Protein of unknown function (DUF770); Region: DUF770; pfam05591
999541010852	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
999541010853	Protein of unknown function (DUF877); Region: DUF877; pfam05943
999541010854	Protein of unknown function (DUF796); Region: DUF796; pfam05638
999541010855	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
999541010856	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
999541010857	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
999541010858	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
999541010859	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
999541010860	Clp amino terminal domain; Region: Clp_N; pfam02861
999541010861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541010862	Walker A motif; other site
999541010863	ATP binding site [chemical binding]; other site
999541010864	Walker B motif; other site
999541010865	arginine finger; other site
999541010866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541010867	Walker A motif; other site
999541010868	ATP binding site [chemical binding]; other site
999541010869	Walker B motif; other site
999541010870	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
999541010871	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
999541010872	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
999541010873	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541010874	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541010875	ligand binding site [chemical binding]; other site
999541010876	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
999541010877	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
999541010878	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
999541010879	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
999541010880	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
999541010881	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
999541010882	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
999541010883	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
999541010884	Cl binding site [ion binding]; other site
999541010885	oligomer interface [polypeptide binding]; other site
999541010886	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
999541010887	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541010888	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541010889	NAD(P) binding site [chemical binding]; other site
999541010890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541010891	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541010892	putative effector binding pocket; other site
999541010893	dimerization interface [polypeptide binding]; other site
999541010894	Water Stress and Hypersensitive response; Region: WHy; smart00769
999541010895	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
999541010896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541010897	S-adenosylmethionine binding site [chemical binding]; other site
999541010898	Methyltransferase domain; Region: Methyltransf_32; pfam13679
999541010899	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541010900	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
999541010901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541010902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541010903	D-galactonate transporter; Region: 2A0114; TIGR00893
999541010904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541010905	putative substrate translocation pore; other site
999541010906	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
999541010907	putative FMN binding site [chemical binding]; other site
999541010908	putative chaperone; Provisional; Region: PRK11678
999541010909	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
999541010910	nucleotide binding site [chemical binding]; other site
999541010911	putative NEF/HSP70 interaction site [polypeptide binding]; other site
999541010912	SBD interface [polypeptide binding]; other site
999541010913	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541010914	DNA-binding site [nucleotide binding]; DNA binding site
999541010915	RNA-binding motif; other site
999541010916	amino acid transporter; Region: 2A0306; TIGR00909
999541010917	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
999541010918	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
999541010919	putative active site [active]
999541010920	metal binding site [ion binding]; metal-binding site
999541010921	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
999541010922	Flavoprotein; Region: Flavoprotein; pfam02441
999541010923	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
999541010924	putative GSH binding site [chemical binding]; other site
999541010925	catalytic residues [active]
999541010926	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
999541010927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541010928	peptide chain release factor 1; Validated; Region: prfA; PRK00591
999541010929	This domain is found in peptide chain release factors; Region: PCRF; smart00937
999541010930	RF-1 domain; Region: RF-1; pfam00472
999541010931	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
999541010932	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
999541010933	tRNA; other site
999541010934	putative tRNA binding site [nucleotide binding]; other site
999541010935	putative NADP binding site [chemical binding]; other site
999541010936	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
999541010937	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
999541010938	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
999541010939	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
999541010940	active site
999541010941	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
999541010942	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
999541010943	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
999541010944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541010945	Walker A/P-loop; other site
999541010946	ATP binding site [chemical binding]; other site
999541010947	Q-loop/lid; other site
999541010948	ABC transporter signature motif; other site
999541010949	Walker B; other site
999541010950	D-loop; other site
999541010951	H-loop/switch region; other site
999541010952	ABC transporter; Region: ABC_tran_2; pfam12848
999541010953	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541010954	Protein of unknown function (DUF419); Region: DUF419; cl15265
999541010955	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
999541010956	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541010957	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541010958	active site
999541010959	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
999541010960	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
999541010961	O-Antigen ligase; Region: Wzy_C; pfam04932
999541010962	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
999541010963	multidrug efflux protein; Reviewed; Region: PRK09579
999541010964	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541010965	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541010966	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541010967	Protein of unknown function, DUF606; Region: DUF606; pfam04657
999541010968	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541010969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541010970	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
999541010971	putative substrate binding pocket [chemical binding]; other site
999541010972	putative dimerization interface [polypeptide binding]; other site
999541010973	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541010974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541010975	S-adenosylmethionine binding site [chemical binding]; other site
999541010976	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
999541010977	dimerization interface [polypeptide binding]; other site
999541010978	active site
999541010979	FOG: WD40 repeat [General function prediction only]; Region: COG2319
999541010980	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
999541010981	structural tetrad; other site
999541010982	FOG: WD40 repeat [General function prediction only]; Region: COG2319
999541010983	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
999541010984	structural tetrad; other site
999541010985	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
999541010986	structural tetrad; other site
999541010987	Uncharacterized conserved protein [Function unknown]; Region: COG1262
999541010988	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
999541010989	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
999541010990	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
999541010991	catalytic motif [active]
999541010992	Zn binding site [ion binding]; other site
999541010993	RibD C-terminal domain; Region: RibD_C; cl17279
999541010994	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
999541010995	homodimer interface [polypeptide binding]; other site
999541010996	chemical substrate binding site [chemical binding]; other site
999541010997	oligomer interface [polypeptide binding]; other site
999541010998	metal binding site [ion binding]; metal-binding site
999541010999	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
999541011000	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
999541011001	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
999541011002	GTP-binding protein YchF; Reviewed; Region: PRK09601
999541011003	YchF GTPase; Region: YchF; cd01900
999541011004	G1 box; other site
999541011005	GTP/Mg2+ binding site [chemical binding]; other site
999541011006	Switch I region; other site
999541011007	G2 box; other site
999541011008	Switch II region; other site
999541011009	G3 box; other site
999541011010	G4 box; other site
999541011011	G5 box; other site
999541011012	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
999541011013	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
999541011014	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
999541011015	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
999541011016	dimerization domain [polypeptide binding]; other site
999541011017	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
999541011018	dimer interface [polypeptide binding]; other site
999541011019	catalytic residues [active]
999541011020	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
999541011021	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
999541011022	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541011023	protein binding site [polypeptide binding]; other site
999541011024	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541011025	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541011026	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
999541011027	ligand binding site [chemical binding]; other site
999541011028	active site
999541011029	UGI interface [polypeptide binding]; other site
999541011030	catalytic site [active]
999541011031	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
999541011032	putative active site [active]
999541011033	putative metal binding residues [ion binding]; other site
999541011034	signature motif; other site
999541011035	putative triphosphate binding site [ion binding]; other site
999541011036	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
999541011037	active site
999541011038	ribulose/triose binding site [chemical binding]; other site
999541011039	phosphate binding site [ion binding]; other site
999541011040	substrate (anthranilate) binding pocket [chemical binding]; other site
999541011041	product (indole) binding pocket [chemical binding]; other site
999541011042	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
999541011043	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
999541011044	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
999541011045	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
999541011046	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
999541011047	glutamine binding [chemical binding]; other site
999541011048	catalytic triad [active]
999541011049	anthranilate synthase component I; Provisional; Region: PRK13565
999541011050	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
999541011051	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
999541011052	phosphoglycolate phosphatase; Provisional; Region: PRK13222
999541011053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541011054	motif II; other site
999541011055	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
999541011056	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
999541011057	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
999541011058	substrate binding site [chemical binding]; other site
999541011059	hexamer interface [polypeptide binding]; other site
999541011060	metal binding site [ion binding]; metal-binding site
999541011061	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
999541011062	MltA specific insert domain; Region: MltA; smart00925
999541011063	3D domain; Region: 3D; pfam06725
999541011064	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
999541011065	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
999541011066	active site
999541011067	AMP binding site [chemical binding]; other site
999541011068	homodimer interface [polypeptide binding]; other site
999541011069	acyl-activating enzyme (AAE) consensus motif; other site
999541011070	CoA binding site [chemical binding]; other site
999541011071	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541011072	CoenzymeA binding site [chemical binding]; other site
999541011073	subunit interaction site [polypeptide binding]; other site
999541011074	PHB binding site; other site
999541011075	enoyl-CoA hydratase; Provisional; Region: PRK08140
999541011076	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541011077	substrate binding site [chemical binding]; other site
999541011078	oxyanion hole (OAH) forming residues; other site
999541011079	trimer interface [polypeptide binding]; other site
999541011080	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
999541011081	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541011082	NAD(P) binding site [chemical binding]; other site
999541011083	catalytic residues [active]
999541011084	enoyl-CoA hydratase; Provisional; Region: PRK05862
999541011085	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541011086	substrate binding site [chemical binding]; other site
999541011087	oxyanion hole (OAH) forming residues; other site
999541011088	trimer interface [polypeptide binding]; other site
999541011089	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
999541011090	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
999541011091	putative [4Fe-4S] binding site [ion binding]; other site
999541011092	putative molybdopterin cofactor binding site [chemical binding]; other site
999541011093	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
999541011094	putative molybdopterin cofactor binding site; other site
999541011095	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
999541011096	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
999541011097	acyl-activating enzyme (AAE) consensus motif; other site
999541011098	putative AMP binding site [chemical binding]; other site
999541011099	putative active site [active]
999541011100	putative CoA binding site [chemical binding]; other site
999541011101	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541011102	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541011103	trimer interface [polypeptide binding]; other site
999541011104	eyelet of channel; other site
999541011105	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
999541011106	diiron binding motif [ion binding]; other site
999541011107	cell division protein MraZ; Reviewed; Region: PRK00326
999541011108	MraZ protein; Region: MraZ; pfam02381
999541011109	MraZ protein; Region: MraZ; pfam02381
999541011110	MraW methylase family; Region: Methyltransf_5; cl17771
999541011111	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
999541011112	Cell division protein FtsL; Region: FtsL; cl11433
999541011113	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
999541011114	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
999541011115	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
999541011116	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
999541011117	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541011118	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541011119	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
999541011120	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
999541011121	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541011122	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541011123	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
999541011124	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
999541011125	Mg++ binding site [ion binding]; other site
999541011126	putative catalytic motif [active]
999541011127	putative substrate binding site [chemical binding]; other site
999541011128	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
999541011129	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541011130	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541011131	cell division protein FtsW; Region: ftsW; TIGR02614
999541011132	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
999541011133	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
999541011134	active site
999541011135	homodimer interface [polypeptide binding]; other site
999541011136	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
999541011137	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
999541011138	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541011139	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541011140	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
999541011141	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
999541011142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541011143	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
999541011144	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
999541011145	Cell division protein FtsQ; Region: FtsQ; pfam03799
999541011146	cell division protein FtsA; Region: ftsA; TIGR01174
999541011147	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
999541011148	nucleotide binding site [chemical binding]; other site
999541011149	Cell division protein FtsA; Region: FtsA; pfam14450
999541011150	cell division protein FtsZ; Validated; Region: PRK09330
999541011151	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
999541011152	nucleotide binding site [chemical binding]; other site
999541011153	SulA interaction site; other site
999541011154	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
999541011155	catalytic triad [active]
999541011156	dimer interface [polypeptide binding]; other site
999541011157	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
999541011158	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
999541011159	Protein of unknown function (DUF721); Region: DUF721; pfam05258
999541011160	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
999541011161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
999541011162	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
999541011163	SEC-C motif; Region: SEC-C; pfam02810
999541011164	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
999541011165	heterotetramer interface [polypeptide binding]; other site
999541011166	active site pocket [active]
999541011167	cleavage site
999541011168	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
999541011169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541011170	Walker A motif; other site
999541011171	ATP binding site [chemical binding]; other site
999541011172	Walker B motif; other site
999541011173	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
999541011174	active site
999541011175	8-oxo-dGMP binding site [chemical binding]; other site
999541011176	nudix motif; other site
999541011177	metal binding site [ion binding]; metal-binding site
999541011178	Domain of unknown function (DUF329); Region: DUF329; pfam03884
999541011179	hypothetical protein; Provisional; Region: PRK05287
999541011180	dephospho-CoA kinase; Region: TIGR00152
999541011181	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
999541011182	CoA-binding site [chemical binding]; other site
999541011183	ATP-binding [chemical binding]; other site
999541011184	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
999541011185	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
999541011186	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
999541011187	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
999541011188	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541011189	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541011190	Type II/IV secretion system protein; Region: T2SE; pfam00437
999541011191	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541011192	Walker A motif; other site
999541011193	ATP binding site [chemical binding]; other site
999541011194	Walker B motif; other site
999541011195	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
999541011196	Domain of unknown function DUF21; Region: DUF21; pfam01595
999541011197	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
999541011198	Transporter associated domain; Region: CorC_HlyC; smart01091
999541011199	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
999541011200	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
999541011201	substrate binding pocket [chemical binding]; other site
999541011202	chain length determination region; other site
999541011203	substrate-Mg2+ binding site; other site
999541011204	catalytic residues [active]
999541011205	aspartate-rich region 1; other site
999541011206	active site lid residues [active]
999541011207	aspartate-rich region 2; other site
999541011208	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
999541011209	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
999541011210	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
999541011211	GTPase CgtA; Reviewed; Region: obgE; PRK12299
999541011212	GTP1/OBG; Region: GTP1_OBG; pfam01018
999541011213	Obg GTPase; Region: Obg; cd01898
999541011214	G1 box; other site
999541011215	GTP/Mg2+ binding site [chemical binding]; other site
999541011216	Switch I region; other site
999541011217	G2 box; other site
999541011218	G3 box; other site
999541011219	Switch II region; other site
999541011220	G4 box; other site
999541011221	G5 box; other site
999541011222	gamma-glutamyl kinase; Provisional; Region: PRK05429
999541011223	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
999541011224	nucleotide binding site [chemical binding]; other site
999541011225	homotetrameric interface [polypeptide binding]; other site
999541011226	putative phosphate binding site [ion binding]; other site
999541011227	putative allosteric binding site; other site
999541011228	PUA domain; Region: PUA; pfam01472
999541011229	CNP1-like family; Region: CNP1; pfam08750
999541011230	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
999541011231	putative active site [active]
999541011232	Ap4A binding site [chemical binding]; other site
999541011233	nudix motif; other site
999541011234	putative metal binding site [ion binding]; other site
999541011235	prolyl-tRNA synthetase; Provisional; Region: PRK09194
999541011236	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
999541011237	dimer interface [polypeptide binding]; other site
999541011238	motif 1; other site
999541011239	active site
999541011240	motif 2; other site
999541011241	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
999541011242	putative deacylase active site [active]
999541011243	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
999541011244	active site
999541011245	motif 3; other site
999541011246	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
999541011247	anticodon binding site; other site
999541011248	MarC family integral membrane protein; Region: MarC; cl00919
999541011249	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541011250	active site
999541011251	signal recognition particle protein; Provisional; Region: PRK10867
999541011252	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
999541011253	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
999541011254	P loop; other site
999541011255	GTP binding site [chemical binding]; other site
999541011256	Signal peptide binding domain; Region: SRP_SPB; pfam02978
999541011257	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
999541011258	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
999541011259	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
999541011260	amidase catalytic site [active]
999541011261	Zn binding residues [ion binding]; other site
999541011262	substrate binding site [chemical binding]; other site
999541011263	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
999541011264	ATP cone domain; Region: ATP-cone; pfam03477
999541011265	Class I ribonucleotide reductase; Region: RNR_I; cd01679
999541011266	active site
999541011267	dimer interface [polypeptide binding]; other site
999541011268	catalytic residues [active]
999541011269	effector binding site; other site
999541011270	R2 peptide binding site; other site
999541011271	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
999541011272	dimer interface [polypeptide binding]; other site
999541011273	putative radical transfer pathway; other site
999541011274	diiron center [ion binding]; other site
999541011275	tyrosyl radical; other site
999541011276	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
999541011277	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541011278	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
999541011279	substrate binding site [chemical binding]; other site
999541011280	ATP binding site [chemical binding]; other site
999541011281	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
999541011282	dimer interface [polypeptide binding]; other site
999541011283	catalytic triad [active]
999541011284	peroxidatic and resolving cysteines [active]
999541011285	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
999541011286	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
999541011287	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
999541011288	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541011289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541011290	S-adenosylmethionine binding site [chemical binding]; other site
999541011291	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
999541011292	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541011293	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541011294	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
999541011295	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
999541011296	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
999541011297	carboxyltransferase (CT) interaction site; other site
999541011298	biotinylation site [posttranslational modification]; other site
999541011299	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
999541011300	Dehydroquinase class II; Region: DHquinase_II; pfam01220
999541011301	active site
999541011302	trimer interface [polypeptide binding]; other site
999541011303	dimer interface [polypeptide binding]; other site
999541011304	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
999541011305	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541011306	catalytic residues [active]
999541011307	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
999541011308	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
999541011309	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
999541011310	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
999541011311	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
999541011312	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541011313	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
999541011314	RNB domain; Region: RNB; pfam00773
999541011315	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
999541011316	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
999541011317	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
999541011318	shikimate binding site; other site
999541011319	NAD(P) binding site [chemical binding]; other site
999541011320	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
999541011321	Transglycosylase; Region: Transgly; cl17702
999541011322	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541011323	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541011324	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541011325	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
999541011326	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
999541011327	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
999541011328	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
999541011329	active site
999541011330	intersubunit interface [polypeptide binding]; other site
999541011331	catalytic residue [active]
999541011332	short chain dehydrogenase; Provisional; Region: PRK07063
999541011333	classical (c) SDRs; Region: SDR_c; cd05233
999541011334	NAD(P) binding site [chemical binding]; other site
999541011335	active site
999541011336	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
999541011337	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
999541011338	ligand binding site [chemical binding]; other site
999541011339	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
999541011340	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541011341	Walker A/P-loop; other site
999541011342	ATP binding site [chemical binding]; other site
999541011343	Q-loop/lid; other site
999541011344	ABC transporter signature motif; other site
999541011345	Walker B; other site
999541011346	D-loop; other site
999541011347	H-loop/switch region; other site
999541011348	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541011349	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541011350	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541011351	TM-ABC transporter signature motif; other site
999541011352	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541011353	classical (c) SDRs; Region: SDR_c; cd05233
999541011354	NAD(P) binding site [chemical binding]; other site
999541011355	active site
999541011356	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
999541011357	active site
999541011358	catalytic residues [active]
999541011359	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
999541011360	active site
999541011361	dimer interface [polypeptide binding]; other site
999541011362	Competence-damaged protein; Region: CinA; pfam02464
999541011363	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
999541011364	tetramer interfaces [polypeptide binding]; other site
999541011365	binuclear metal-binding site [ion binding]; other site
999541011366	thiamine monophosphate kinase; Provisional; Region: PRK05731
999541011367	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
999541011368	ATP binding site [chemical binding]; other site
999541011369	dimerization interface [polypeptide binding]; other site
999541011370	malic enzyme; Reviewed; Region: PRK12862
999541011371	Malic enzyme, N-terminal domain; Region: malic; pfam00390
999541011372	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
999541011373	putative NAD(P) binding site [chemical binding]; other site
999541011374	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
999541011375	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
999541011376	active site
999541011377	barstar interaction site; other site
999541011378	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
999541011379	putative RNAase interaction site [polypeptide binding]; other site
999541011380	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
999541011381	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
999541011382	putative dimer interface [polypeptide binding]; other site
999541011383	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541011384	spermidine synthase; Provisional; Region: PRK00811
999541011385	Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421
999541011386	transketolase; Reviewed; Region: PRK12753
999541011387	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
999541011388	TPP-binding site [chemical binding]; other site
999541011389	dimer interface [polypeptide binding]; other site
999541011390	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
999541011391	PYR/PP interface [polypeptide binding]; other site
999541011392	dimer interface [polypeptide binding]; other site
999541011393	TPP binding site [chemical binding]; other site
999541011394	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
999541011395	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
999541011396	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
999541011397	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
999541011398	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541011399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541011400	DNA-binding site [nucleotide binding]; DNA binding site
999541011401	FCD domain; Region: FCD; pfam07729
999541011402	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
999541011403	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541011404	allantoicase; Provisional; Region: PRK13257
999541011405	Allantoicase repeat; Region: Allantoicase; pfam03561
999541011406	Allantoicase repeat; Region: Allantoicase; pfam03561
999541011407	ureidoglycolate hydrolase; Provisional; Region: PRK13395
999541011408	ferric uptake regulator; Provisional; Region: fur; PRK09462
999541011409	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
999541011410	metal binding site 2 [ion binding]; metal-binding site
999541011411	putative DNA binding helix; other site
999541011412	metal binding site 1 [ion binding]; metal-binding site
999541011413	dimer interface [polypeptide binding]; other site
999541011414	structural Zn2+ binding site [ion binding]; other site
999541011415	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
999541011416	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
999541011417	dihydrodipicolinate reductase; Provisional; Region: PRK00048
999541011418	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
999541011419	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
999541011420	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
999541011421	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541011422	TolR protein; Region: tolR; TIGR02801
999541011423	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
999541011424	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
999541011425	HIGH motif; other site
999541011426	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
999541011427	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541011428	active site
999541011429	KMSKS motif; other site
999541011430	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
999541011431	tRNA binding surface [nucleotide binding]; other site
999541011432	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
999541011433	Lipopolysaccharide-assembly; Region: LptE; cl01125
999541011434	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
999541011435	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
999541011436	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
999541011437	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
999541011438	putative catalytic cysteine [active]
999541011439	Predicted membrane protein [Function unknown]; Region: COG1981
999541011440	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541011441	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541011442	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541011443	putative active site [active]
999541011444	phosphogluconate dehydratase; Validated; Region: PRK09054
999541011445	6-phosphogluconate dehydratase; Region: edd; TIGR01196
999541011446	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
999541011447	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
999541011448	active site
999541011449	intersubunit interface [polypeptide binding]; other site
999541011450	catalytic residue [active]
999541011451	fructuronate transporter; Provisional; Region: PRK10034; cl15264
999541011452	GntP family permease; Region: GntP_permease; pfam02447
999541011453	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
999541011454	ATP-binding site [chemical binding]; other site
999541011455	Gluconate-6-phosphate binding site [chemical binding]; other site
999541011456	Shikimate kinase; Region: SKI; pfam01202
999541011457	adenylosuccinate lyase; Provisional; Region: PRK09285
999541011458	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
999541011459	tetramer interface [polypeptide binding]; other site
999541011460	active site
999541011461	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
999541011462	cell density-dependent motility repressor; Provisional; Region: PRK10082
999541011463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541011465	dimerization interface [polypeptide binding]; other site
999541011466	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
999541011467	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
999541011468	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
999541011469	NAD(P) binding site [chemical binding]; other site
999541011470	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541011471	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541011472	substrate binding pocket [chemical binding]; other site
999541011473	membrane-bound complex binding site; other site
999541011474	hinge residues; other site
999541011475	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541011476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541011477	dimer interface [polypeptide binding]; other site
999541011478	conserved gate region; other site
999541011479	putative PBP binding loops; other site
999541011480	ABC-ATPase subunit interface; other site
999541011481	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541011482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541011483	dimer interface [polypeptide binding]; other site
999541011484	conserved gate region; other site
999541011485	putative PBP binding loops; other site
999541011486	ABC-ATPase subunit interface; other site
999541011487	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541011488	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541011489	Walker A/P-loop; other site
999541011490	ATP binding site [chemical binding]; other site
999541011491	Q-loop/lid; other site
999541011492	ABC transporter signature motif; other site
999541011493	Walker B; other site
999541011494	D-loop; other site
999541011495	H-loop/switch region; other site
999541011496	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
999541011497	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
999541011498	putative dimer interface [polypeptide binding]; other site
999541011499	putative active site [active]
999541011500	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
999541011501	active site
999541011502	substrate binding pocket [chemical binding]; other site
999541011503	dimer interface [polypeptide binding]; other site
999541011504	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
999541011505	OsmC-like protein; Region: OsmC; cl00767
999541011506	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
999541011507	23S rRNA interface [nucleotide binding]; other site
999541011508	L3 interface [polypeptide binding]; other site
999541011509	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
999541011510	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
999541011511	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
999541011512	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
999541011513	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
999541011514	active site
999541011515	HIGH motif; other site
999541011516	dimer interface [polypeptide binding]; other site
999541011517	KMSKS motif; other site
999541011518	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541011519	RNA binding surface [nucleotide binding]; other site
999541011520	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
999541011521	putative active site [active]
999541011522	dimerization interface [polypeptide binding]; other site
999541011523	putative tRNAtyr binding site [nucleotide binding]; other site
999541011524	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541011525	catalytic core [active]
999541011526	Putative ParB-like nuclease; Region: ParBc_2; cl17538
999541011527	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
999541011528	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
999541011529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541011530	Walker A motif; other site
999541011531	ATP binding site [chemical binding]; other site
999541011532	Walker B motif; other site
999541011533	arginine finger; other site
999541011534	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
999541011535	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
999541011536	RuvA N terminal domain; Region: RuvA_N; pfam01330
999541011537	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
999541011538	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
999541011539	active site
999541011540	putative DNA-binding cleft [nucleotide binding]; other site
999541011541	dimer interface [polypeptide binding]; other site
999541011542	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
999541011543	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
999541011544	purine monophosphate binding site [chemical binding]; other site
999541011545	dimer interface [polypeptide binding]; other site
999541011546	putative catalytic residues [active]
999541011547	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
999541011548	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
999541011549	DNA-binding protein Fis; Provisional; Region: PRK01905
999541011550	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
999541011551	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
999541011552	FMN binding site [chemical binding]; other site
999541011553	active site
999541011554	catalytic residues [active]
999541011555	substrate binding site [chemical binding]; other site
999541011556	hypothetical protein; Provisional; Region: PRK06996
999541011557	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541011558	proline aminopeptidase P II; Provisional; Region: PRK10879
999541011559	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
999541011560	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
999541011561	active site
999541011562	putative glutathione S-transferase; Provisional; Region: PRK10357
999541011563	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
999541011564	putative C-terminal domain interface [polypeptide binding]; other site
999541011565	putative GSH binding site (G-site) [chemical binding]; other site
999541011566	putative dimer interface [polypeptide binding]; other site
999541011567	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
999541011568	dimer interface [polypeptide binding]; other site
999541011569	N-terminal domain interface [polypeptide binding]; other site
999541011570	putative substrate binding pocket (H-site) [chemical binding]; other site
999541011571	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
999541011572	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
999541011573	active site
999541011574	FMN binding site [chemical binding]; other site
999541011575	substrate binding site [chemical binding]; other site
999541011576	3Fe-4S cluster binding site [ion binding]; other site
999541011577	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
999541011578	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
999541011579	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
999541011580	nudix motif; other site
999541011581	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
999541011582	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
999541011583	ligand binding site [chemical binding]; other site
999541011584	homodimer interface [polypeptide binding]; other site
999541011585	NAD(P) binding site [chemical binding]; other site
999541011586	trimer interface B [polypeptide binding]; other site
999541011587	trimer interface A [polypeptide binding]; other site
999541011588	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
999541011589	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
999541011590	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
999541011591	Predicted transcriptional regulator [Transcription]; Region: COG2378
999541011592	HTH domain; Region: HTH_11; pfam08279
999541011593	WYL domain; Region: WYL; pfam13280
999541011594	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
999541011595	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541011596	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
999541011597	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
999541011598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541011599	Site-specific recombinase; Region: SpecificRecomb; pfam10136
999541011600	Protein of unknown function (DUF330); Region: DUF330; pfam03886
999541011601	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
999541011602	mce related protein; Region: MCE; pfam02470
999541011603	mce related protein; Region: MCE; pfam02470
999541011604	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
999541011605	Paraquat-inducible protein A; Region: PqiA; pfam04403
999541011606	Paraquat-inducible protein A; Region: PqiA; pfam04403
999541011607	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541011608	YceI-like domain; Region: YceI; smart00867
999541011609	Uncharacterized conserved protein [Function unknown]; Region: COG2353
999541011610	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
999541011611	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
999541011612	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
999541011613	Protein export membrane protein; Region: SecD_SecF; pfam02355
999541011614	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
999541011615	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
999541011616	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
999541011617	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
999541011618	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
999541011619	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
999541011620	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
999541011621	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
999541011622	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
999541011623	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
999541011624	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
999541011625	generic binding surface II; other site
999541011626	ssDNA binding site; other site
999541011627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541011628	ATP binding site [chemical binding]; other site
999541011629	putative Mg++ binding site [ion binding]; other site
999541011630	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541011631	nucleotide binding region [chemical binding]; other site
999541011632	ATP-binding site [chemical binding]; other site
999541011633	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541011634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011635	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
999541011636	dimerization interface [polypeptide binding]; other site
999541011637	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
999541011638	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
999541011639	dimerization interface [polypeptide binding]; other site
999541011640	DPS ferroxidase diiron center [ion binding]; other site
999541011641	ion pore; other site
999541011642	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
999541011643	Methyltransferase domain; Region: Methyltransf_24; pfam13578
999541011644	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
999541011645	UbiA prenyltransferase family; Region: UbiA; pfam01040
999541011646	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
999541011647	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
999541011648	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
999541011649	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541011650	catalytic residue [active]
999541011651	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
999541011652	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
999541011653	Cysteine-rich domain; Region: CCG; pfam02754
999541011654	Cysteine-rich domain; Region: CCG; pfam02754
999541011655	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
999541011656	FAD binding domain; Region: FAD_binding_4; pfam01565
999541011657	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
999541011658	FAD binding domain; Region: FAD_binding_4; pfam01565
999541011659	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541011660	FAD binding domain; Region: FAD_binding_4; pfam01565
999541011661	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
999541011662	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
999541011663	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
999541011664	heme-binding site [chemical binding]; other site
999541011665	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
999541011666	FAD binding pocket [chemical binding]; other site
999541011667	FAD binding motif [chemical binding]; other site
999541011668	phosphate binding motif [ion binding]; other site
999541011669	beta-alpha-beta structure motif; other site
999541011670	NAD binding pocket [chemical binding]; other site
999541011671	Heme binding  pocket [chemical binding]; other site
999541011672	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
999541011673	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
999541011674	protease TldD; Provisional; Region: tldD; PRK10735
999541011675	nitrilase; Region: PLN02798
999541011676	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
999541011677	putative active site [active]
999541011678	catalytic triad [active]
999541011679	dimer interface [polypeptide binding]; other site
999541011680	TIGR02099 family protein; Region: TIGR02099
999541011681	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
999541011682	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
999541011683	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
999541011684	metal binding triad; other site
999541011685	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
999541011686	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
999541011687	metal binding triad; other site
999541011688	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
999541011689	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
999541011690	Walker A/P-loop; other site
999541011691	ATP binding site [chemical binding]; other site
999541011692	Q-loop/lid; other site
999541011693	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
999541011694	ABC transporter signature motif; other site
999541011695	Walker B; other site
999541011696	D-loop; other site
999541011697	H-loop/switch region; other site
999541011698	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
999541011699	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
999541011700	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
999541011701	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
999541011702	ferrochelatase; Reviewed; Region: hemH; PRK00035
999541011703	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
999541011704	C-terminal domain interface [polypeptide binding]; other site
999541011705	active site
999541011706	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
999541011707	active site
999541011708	N-terminal domain interface [polypeptide binding]; other site
999541011709	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541011710	RNA binding surface [nucleotide binding]; other site
999541011711	GrpE; Region: GrpE; pfam01025
999541011712	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
999541011713	dimer interface [polypeptide binding]; other site
999541011714	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
999541011715	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
999541011716	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
999541011717	nucleotide binding site [chemical binding]; other site
999541011718	chaperone protein DnaJ; Provisional; Region: PRK10767
999541011719	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
999541011720	HSP70 interaction site [polypeptide binding]; other site
999541011721	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
999541011722	Zn binding sites [ion binding]; other site
999541011723	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
999541011724	dimer interface [polypeptide binding]; other site
999541011725	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
999541011726	chorismate binding enzyme; Region: Chorismate_bind; cl10555
999541011727	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
999541011728	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
999541011729	substrate-cofactor binding pocket; other site
999541011730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541011731	catalytic residue [active]
999541011732	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
999541011733	oligomerization interface [polypeptide binding]; other site
999541011734	active site
999541011735	metal binding site [ion binding]; metal-binding site
999541011736	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
999541011737	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
999541011738	Substrate-binding site [chemical binding]; other site
999541011739	Substrate specificity [chemical binding]; other site
999541011740	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
999541011741	catalytic center binding site [active]
999541011742	ATP binding site [chemical binding]; other site
999541011743	poly(A) polymerase; Region: pcnB; TIGR01942
999541011744	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
999541011745	active site
999541011746	NTP binding site [chemical binding]; other site
999541011747	metal binding triad [ion binding]; metal-binding site
999541011748	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
999541011749	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
999541011750	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
999541011751	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
999541011752	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
999541011753	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
999541011754	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
999541011755	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
999541011756	dimerization interface [polypeptide binding]; other site
999541011757	putative ATP binding site [chemical binding]; other site
999541011758	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
999541011759	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
999541011760	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
999541011761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541011762	ATP binding site [chemical binding]; other site
999541011763	Mg2+ binding site [ion binding]; other site
999541011764	G-X-G motif; other site
999541011765	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
999541011766	ATP binding site [chemical binding]; other site
999541011767	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
999541011768	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
999541011769	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
999541011770	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
999541011771	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541011772	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
999541011773	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
999541011774	putative active site [active]
999541011775	putative dimer interface [polypeptide binding]; other site
999541011776	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
999541011777	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
999541011778	Substrate binding site; other site
999541011779	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
999541011780	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
999541011781	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
999541011782	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541011783	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011784	polysaccharide export protein Wza; Provisional; Region: PRK15078
999541011785	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541011786	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
999541011787	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011788	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541011789	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541011790	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011791	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011792	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
999541011793	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
999541011794	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
999541011795	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
999541011796	NADP-binding site; other site
999541011797	homotetramer interface [polypeptide binding]; other site
999541011798	substrate binding site [chemical binding]; other site
999541011799	homodimer interface [polypeptide binding]; other site
999541011800	active site
999541011801	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541011802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541011803	NAD(P) binding site [chemical binding]; other site
999541011804	active site
999541011805	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011806	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541011807	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541011808	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541011809	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
999541011810	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
999541011811	Walker A/P-loop; other site
999541011812	ATP binding site [chemical binding]; other site
999541011813	Q-loop/lid; other site
999541011814	ABC transporter signature motif; other site
999541011815	Walker B; other site
999541011816	D-loop; other site
999541011817	H-loop/switch region; other site
999541011818	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
999541011819	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
999541011820	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
999541011821	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
999541011822	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
999541011823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541011824	NAD(P) binding site [chemical binding]; other site
999541011825	active site
999541011826	Sulfatase; Region: Sulfatase; cl17466
999541011827	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541011828	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541011829	active site
999541011830	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
999541011831	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541011832	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541011833	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
999541011834	Enoylreductase; Region: PKS_ER; smart00829
999541011835	NAD(P) binding site [chemical binding]; other site
999541011836	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
999541011837	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541011838	putative NADP binding site [chemical binding]; other site
999541011839	active site
999541011840	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541011841	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187
999541011842	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
999541011843	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
999541011844	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541011845	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541011846	catalytic residue [active]
999541011847	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
999541011848	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541011849	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
999541011850	active site
999541011851	homodimer interface [polypeptide binding]; other site
999541011852	homotetramer interface [polypeptide binding]; other site
999541011853	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
999541011854	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541011855	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541011856	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541011857	conserved cys residue [active]
999541011858	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541011859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541011860	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
999541011861	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
999541011862	dimerization interface [polypeptide binding]; other site
999541011863	ligand binding site [chemical binding]; other site
999541011864	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541011865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011866	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541011867	putative effector binding pocket; other site
999541011868	dimerization interface [polypeptide binding]; other site
999541011869	short chain dehydrogenase; Provisional; Region: PRK06500
999541011870	classical (c) SDRs; Region: SDR_c; cd05233
999541011871	NAD(P) binding site [chemical binding]; other site
999541011872	active site
999541011873	transcriptional regulator; Provisional; Region: PRK10632
999541011874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011875	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541011876	putative effector binding pocket; other site
999541011877	dimerization interface [polypeptide binding]; other site
999541011878	short chain dehydrogenase; Provisional; Region: PRK06172
999541011879	classical (c) SDRs; Region: SDR_c; cd05233
999541011880	NAD(P) binding site [chemical binding]; other site
999541011881	active site
999541011882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541011883	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541011884	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541011885	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541011886	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541011887	Tetratricopeptide repeat; Region: TPR_16; pfam13432
999541011888	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541011889	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541011890	ligand binding site [chemical binding]; other site
999541011891	translocation protein TolB; Provisional; Region: tolB; PRK02889
999541011892	TolB amino-terminal domain; Region: TolB_N; pfam04052
999541011893	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
999541011894	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
999541011895	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
999541011896	TolA protein; Region: tolA_full; TIGR02794
999541011897	TonB C terminal; Region: TonB_2; pfam13103
999541011898	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541011899	TolR protein; Region: tolR; TIGR02801
999541011900	TolQ protein; Region: tolQ; TIGR02796
999541011901	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
999541011902	active site
999541011903	malonic semialdehyde reductase; Provisional; Region: PRK10538
999541011904	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
999541011905	putative NAD(P) binding site [chemical binding]; other site
999541011906	homodimer interface [polypeptide binding]; other site
999541011907	homotetramer interface [polypeptide binding]; other site
999541011908	active site
999541011909	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
999541011910	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
999541011911	dimer interface [polypeptide binding]; other site
999541011912	active site
999541011913	glycine-pyridoxal phosphate binding site [chemical binding]; other site
999541011914	folate binding site [chemical binding]; other site
999541011915	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
999541011916	ATP cone domain; Region: ATP-cone; pfam03477
999541011917	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
999541011918	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
999541011919	Predicted membrane protein [Function unknown]; Region: COG5393
999541011920	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
999541011921	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
999541011922	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
999541011923	dimer interface [polypeptide binding]; other site
999541011924	decamer (pentamer of dimers) interface [polypeptide binding]; other site
999541011925	catalytic triad [active]
999541011926	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
999541011927	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541011928	FAD binding site [chemical binding]; other site
999541011929	substrate binding pocket [chemical binding]; other site
999541011930	catalytic base [active]
999541011931	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541011932	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541011933	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541011934	EAL domain; Region: EAL; pfam00563
999541011935	benzoate transport; Region: 2A0115; TIGR00895
999541011936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541011937	putative substrate translocation pore; other site
999541011938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541011939	putative substrate translocation pore; other site
999541011940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541011941	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541011942	putative substrate translocation pore; other site
999541011943	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541011944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541011945	putative substrate translocation pore; other site
999541011946	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
999541011947	putative FMN binding site [chemical binding]; other site
999541011948	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011949	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541011950	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541011951	putative effector binding pocket; other site
999541011952	dimerization interface [polypeptide binding]; other site
999541011953	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
999541011954	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541011955	catalytic residue [active]
999541011956	major facilitator superfamily transporter; Provisional; Region: PRK05122
999541011957	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
999541011958	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
999541011959	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
999541011960	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
999541011961	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
999541011962	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
999541011963	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541011964	XdhC Rossmann domain; Region: XdhC_C; pfam13478
999541011965	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541011966	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
999541011967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
999541011968	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541011969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541011971	dimerization interface [polypeptide binding]; other site
999541011972	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
999541011973	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
999541011974	putative catalytic residue [active]
999541011975	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
999541011976	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
999541011977	BON domain; Region: BON; cl02771
999541011978	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
999541011979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541011980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541011981	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541011982	putative effector binding pocket; other site
999541011983	dimerization interface [polypeptide binding]; other site
999541011984	dihydroxyacetone kinase; Provisional; Region: PRK14479
999541011985	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
999541011986	DAK2 domain; Region: Dak2; pfam02734
999541011987	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
999541011988	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
999541011989	active site residue [active]
999541011990	Epoxide hydrolase N terminus; Region: EHN; pfam06441
999541011991	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541011992	MarR family; Region: MarR_2; pfam12802
999541011993	periplasmic protein; Provisional; Region: PRK10568
999541011994	BON domain; Region: BON; cl02771
999541011995	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
999541011996	nudix motif; other site
999541011997	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
999541011998	oligomerisation interface [polypeptide binding]; other site
999541011999	mobile loop; other site
999541012000	roof hairpin; other site
999541012001	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
999541012002	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
999541012003	ring oligomerisation interface [polypeptide binding]; other site
999541012004	ATP/Mg binding site [chemical binding]; other site
999541012005	stacking interactions; other site
999541012006	hinge regions; other site
999541012007	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
999541012008	dimer interface [polypeptide binding]; other site
999541012009	substrate binding site [chemical binding]; other site
999541012010	ATP binding site [chemical binding]; other site
999541012011	Rubredoxin [Energy production and conversion]; Region: COG1773
999541012012	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
999541012013	iron binding site [ion binding]; other site
999541012014	hypothetical protein; Validated; Region: PRK00228
999541012015	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
999541012016	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541012017	active site
999541012018	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
999541012019	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
999541012020	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
999541012021	dihydroorotase; Provisional; Region: PRK07627
999541012022	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
999541012023	active site
999541012024	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
999541012025	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
999541012026	putative acyl-acceptor binding pocket; other site
999541012027	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
999541012028	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
999541012029	active site
999541012030	metal binding site [ion binding]; metal-binding site
999541012031	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
999541012032	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
999541012033	NAD binding site [chemical binding]; other site
999541012034	substrate binding site [chemical binding]; other site
999541012035	homodimer interface [polypeptide binding]; other site
999541012036	active site
999541012037	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
999541012038	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
999541012039	substrate binding site; other site
999541012040	tetramer interface; other site
999541012041	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
999541012042	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
999541012043	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
999541012044	NADP binding site [chemical binding]; other site
999541012045	active site
999541012046	putative substrate binding site [chemical binding]; other site
999541012047	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
999541012048	Ligand binding site; other site
999541012049	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
999541012050	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541012051	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
999541012052	Probable Catalytic site; other site
999541012053	metal-binding site
999541012054	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541012055	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
999541012056	Probable Catalytic site; other site
999541012057	metal-binding site
999541012058	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
999541012059	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
999541012060	Walker A/P-loop; other site
999541012061	ATP binding site [chemical binding]; other site
999541012062	Q-loop/lid; other site
999541012063	ABC transporter signature motif; other site
999541012064	Walker B; other site
999541012065	D-loop; other site
999541012066	H-loop/switch region; other site
999541012067	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
999541012068	putative carbohydrate binding site [chemical binding]; other site
999541012069	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
999541012070	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
999541012071	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
999541012072	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
999541012073	Walker A/P-loop; other site
999541012074	ATP binding site [chemical binding]; other site
999541012075	Q-loop/lid; other site
999541012076	ABC transporter signature motif; other site
999541012077	Walker B; other site
999541012078	D-loop; other site
999541012079	H-loop/switch region; other site
999541012080	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
999541012081	putative carbohydrate binding site [chemical binding]; other site
999541012082	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541012083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541012084	S-adenosylmethionine binding site [chemical binding]; other site
999541012085	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
999541012086	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541012087	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
999541012088	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
999541012089	trimer interface [polypeptide binding]; other site
999541012090	active site
999541012091	substrate binding site [chemical binding]; other site
999541012092	CoA binding site [chemical binding]; other site
999541012093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541012094	active site
999541012095	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541012096	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541012097	active site
999541012098	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541012099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541012100	NAD(P) binding site [chemical binding]; other site
999541012101	active site
999541012102	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
999541012103	Mg++ binding site [ion binding]; other site
999541012104	putative catalytic motif [active]
999541012105	putative substrate binding site [chemical binding]; other site
999541012106	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
999541012107	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
999541012108	NAD(P) binding site [chemical binding]; other site
999541012109	homodimer interface [polypeptide binding]; other site
999541012110	substrate binding site [chemical binding]; other site
999541012111	active site
999541012112	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
999541012113	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
999541012114	Mg++ binding site [ion binding]; other site
999541012115	putative catalytic motif [active]
999541012116	UDP-glucose 4-epimerase; Region: PLN02240
999541012117	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
999541012118	NAD binding site [chemical binding]; other site
999541012119	homodimer interface [polypeptide binding]; other site
999541012120	active site
999541012121	substrate binding site [chemical binding]; other site
999541012122	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
999541012123	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541012124	putative ADP-binding pocket [chemical binding]; other site
999541012125	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541012126	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541012127	active site
999541012128	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
999541012129	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
999541012130	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
999541012131	active site
999541012132	substrate binding site [chemical binding]; other site
999541012133	metal binding site [ion binding]; metal-binding site
999541012134	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
999541012135	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541012136	putative active site [active]
999541012137	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
999541012138	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
999541012139	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
999541012140	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541012141	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541012142	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
999541012143	UreF; Region: UreF; pfam01730
999541012144	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
999541012145	dimer interface [polypeptide binding]; other site
999541012146	catalytic residues [active]
999541012147	urease subunit alpha; Reviewed; Region: ureC; PRK13207
999541012148	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
999541012149	subunit interactions [polypeptide binding]; other site
999541012150	active site
999541012151	flap region; other site
999541012152	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
999541012153	gamma-beta subunit interface [polypeptide binding]; other site
999541012154	alpha-beta subunit interface [polypeptide binding]; other site
999541012155	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
999541012156	alpha-gamma subunit interface [polypeptide binding]; other site
999541012157	beta-gamma subunit interface [polypeptide binding]; other site
999541012158	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
999541012159	Predicted membrane protein [Function unknown]; Region: COG4709
999541012160	Predicted transcriptional regulators [Transcription]; Region: COG1695
999541012161	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
999541012162	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
999541012163	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
999541012164	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
999541012165	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
999541012166	active site
999541012167	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
999541012168	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541012169	Walker A/P-loop; other site
999541012170	ATP binding site [chemical binding]; other site
999541012171	Q-loop/lid; other site
999541012172	ABC transporter signature motif; other site
999541012173	Walker B; other site
999541012174	D-loop; other site
999541012175	H-loop/switch region; other site
999541012176	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
999541012177	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541012178	Walker A/P-loop; other site
999541012179	ATP binding site [chemical binding]; other site
999541012180	Q-loop/lid; other site
999541012181	ABC transporter signature motif; other site
999541012182	Walker B; other site
999541012183	D-loop; other site
999541012184	H-loop/switch region; other site
999541012185	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541012186	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541012187	TM-ABC transporter signature motif; other site
999541012188	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541012189	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541012190	TM-ABC transporter signature motif; other site
999541012191	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
999541012192	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
999541012193	putative ligand binding site [chemical binding]; other site
999541012194	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
999541012195	active site residue [active]
999541012196	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
999541012197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541012198	S-adenosylmethionine binding site [chemical binding]; other site
999541012199	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
999541012200	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541012201	FeS/SAM binding site; other site
999541012202	HemN C-terminal domain; Region: HemN_C; pfam06969
999541012203	Flagellin N-methylase; Region: FliB; pfam03692
999541012204	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
999541012205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541012206	S-adenosylmethionine binding site [chemical binding]; other site
999541012207	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541012208	MULE transposase domain; Region: MULE; pfam10551
999541012209	chromosome condensation membrane protein; Provisional; Region: PRK14196
999541012210	YGGT family; Region: YGGT; pfam02325
999541012211	YGGT family; Region: YGGT; pfam02325
999541012212	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
999541012213	LysE type translocator; Region: LysE; cl00565
999541012214	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
999541012215	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541012216	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541012217	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541012218	catalytic residue [active]
999541012219	aminotransferase; Validated; Region: PRK07337
999541012220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541012221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541012222	homodimer interface [polypeptide binding]; other site
999541012223	catalytic residue [active]
999541012224	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
999541012225	putative RNA binding site [nucleotide binding]; other site
999541012226	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
999541012227	homopentamer interface [polypeptide binding]; other site
999541012228	active site
999541012229	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
999541012230	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
999541012231	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
999541012232	dimerization interface [polypeptide binding]; other site
999541012233	active site
999541012234	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541012235	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
999541012236	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
999541012237	potential catalytic triad [active]
999541012238	conserved cys residue [active]
999541012239	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
999541012240	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
999541012241	Cupin; Region: Cupin_1; smart00835
999541012242	Cupin; Region: Cupin_1; smart00835
999541012243	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
999541012244	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541012245	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541012246	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541012247	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541012248	catalytic residue [active]
999541012249	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
999541012250	VirB7 interaction site; other site
999541012251	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
999541012252	EamA-like transporter family; Region: EamA; pfam00892
999541012253	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541012254	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541012255	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
999541012256	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
999541012257	trimer interface [polypeptide binding]; other site
999541012258	active site
999541012259	substrate binding site [chemical binding]; other site
999541012260	CoA binding site [chemical binding]; other site
999541012261	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
999541012262	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
999541012263	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541012264	Moco binding site; other site
999541012265	metal coordination site [ion binding]; other site
999541012266	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
999541012267	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
999541012268	Lumazine binding domain; Region: Lum_binding; pfam00677
999541012269	Lumazine binding domain; Region: Lum_binding; pfam00677
999541012270	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
999541012271	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
999541012272	catalytic motif [active]
999541012273	Zn binding site [ion binding]; other site
999541012274	RibD C-terminal domain; Region: RibD_C; cl17279
999541012275	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
999541012276	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541012277	inhibitor-cofactor binding pocket; inhibition site
999541012278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541012279	catalytic residue [active]
999541012280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541012281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541012282	putative substrate translocation pore; other site
999541012283	bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101
999541012284	glucokinase; Provisional; Region: glk; PRK00292
999541012285	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541012286	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541012287	putative active site [active]
999541012288	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
999541012289	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
999541012290	putative active site [active]
999541012291	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
999541012292	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
999541012293	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
999541012294	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
999541012295	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
999541012296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541012297	dimer interface [polypeptide binding]; other site
999541012298	conserved gate region; other site
999541012299	putative PBP binding loops; other site
999541012300	ABC-ATPase subunit interface; other site
999541012301	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
999541012302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541012303	dimer interface [polypeptide binding]; other site
999541012304	conserved gate region; other site
999541012305	putative PBP binding loops; other site
999541012306	ABC-ATPase subunit interface; other site
999541012307	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
999541012308	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
999541012309	Walker A/P-loop; other site
999541012310	ATP binding site [chemical binding]; other site
999541012311	Q-loop/lid; other site
999541012312	ABC transporter signature motif; other site
999541012313	Walker B; other site
999541012314	D-loop; other site
999541012315	H-loop/switch region; other site
999541012316	TOBE domain; Region: TOBE_2; pfam08402
999541012317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
999541012318	Smr domain; Region: Smr; pfam01713
999541012319	thioredoxin reductase; Provisional; Region: PRK10262
999541012320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541012321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541012322	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
999541012323	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
999541012324	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
999541012325	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
999541012326	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
999541012327	recombination factor protein RarA; Reviewed; Region: PRK13342
999541012328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541012329	Walker A motif; other site
999541012330	ATP binding site [chemical binding]; other site
999541012331	Walker B motif; other site
999541012332	arginine finger; other site
999541012333	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
999541012334	seryl-tRNA synthetase; Provisional; Region: PRK05431
999541012335	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
999541012336	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
999541012337	dimer interface [polypeptide binding]; other site
999541012338	active site
999541012339	motif 1; other site
999541012340	motif 2; other site
999541012341	motif 3; other site
999541012342	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
999541012343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541012344	Coenzyme A binding pocket [chemical binding]; other site
999541012345	septum formation inhibitor; Reviewed; Region: PRK01973
999541012346	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
999541012347	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
999541012348	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
999541012349	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
999541012350	Switch I; other site
999541012351	Switch II; other site
999541012352	cell division topological specificity factor MinE; Provisional; Region: PRK13989
999541012353	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
999541012354	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
999541012355	putative ion selectivity filter; other site
999541012356	putative pore gating glutamate residue; other site
999541012357	putative H+/Cl- coupling transport residue; other site
999541012358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541012359	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541012360	putative substrate translocation pore; other site
999541012361	Gram-negative bacterial tonB protein; Region: TonB; cl10048
999541012362	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541012363	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
999541012364	Divergent AAA domain; Region: AAA_4; pfam04326
999541012365	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
999541012366	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
999541012367	tandem repeat interface [polypeptide binding]; other site
999541012368	oligomer interface [polypeptide binding]; other site
999541012369	active site residues [active]
999541012370	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
999541012371	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
999541012372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
999541012373	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
999541012374	active site
999541012375	metal binding site [ion binding]; metal-binding site
999541012376	interdomain interaction site; other site
999541012377	Domain of unknown function (DUF927); Region: DUF927; pfam06048
999541012378	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
999541012379	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
999541012380	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
999541012381	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
999541012382	active site
999541012383	Int/Topo IB signature motif; other site
999541012384	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
999541012385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541012386	FeS/SAM binding site; other site
999541012387	HemN C-terminal domain; Region: HemN_C; pfam06969
999541012388	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
999541012389	active site
999541012390	dimerization interface [polypeptide binding]; other site
999541012391	ribonuclease PH; Reviewed; Region: rph; PRK00173
999541012392	Ribonuclease PH; Region: RNase_PH_bact; cd11362
999541012393	hexamer interface [polypeptide binding]; other site
999541012394	active site
999541012395	hypothetical protein; Provisional; Region: PRK11820
999541012396	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
999541012397	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
999541012398	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
999541012399	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
999541012400	catalytic site [active]
999541012401	G-X2-G-X-G-K; other site
999541012402	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
999541012403	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
999541012404	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541012405	Zn2+ binding site [ion binding]; other site
999541012406	Mg2+ binding site [ion binding]; other site
999541012407	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
999541012408	synthetase active site [active]
999541012409	NTP binding site [chemical binding]; other site
999541012410	metal binding site [ion binding]; metal-binding site
999541012411	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
999541012412	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
999541012413	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
999541012414	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
999541012415	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
999541012416	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541012417	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541012418	trimer interface [polypeptide binding]; other site
999541012419	eyelet of channel; other site
999541012420	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541012421	DNA-binding site [nucleotide binding]; DNA binding site
999541012422	RNA-binding motif; other site
999541012423	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
999541012424	active site
999541012425	catalytic site [active]
999541012426	substrate binding site [chemical binding]; other site
999541012427	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
999541012428	GIY-YIG motif/motif A; other site
999541012429	active site
999541012430	catalytic site [active]
999541012431	putative DNA binding site [nucleotide binding]; other site
999541012432	metal binding site [ion binding]; metal-binding site
999541012433	chorismate mutase; Provisional; Region: PRK09269
999541012434	chorismate mutase, putative; Region: CM_mono2; TIGR01806
999541012435	fructose-1,6-bisphosphatase family protein; Region: PLN02628
999541012436	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
999541012437	AMP binding site [chemical binding]; other site
999541012438	metal binding site [ion binding]; metal-binding site
999541012439	active site
999541012440	aminopeptidase N; Provisional; Region: pepN; PRK14015
999541012441	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
999541012442	active site
999541012443	Zn binding site [ion binding]; other site
999541012444	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
999541012445	guanine deaminase; Provisional; Region: PRK09228
999541012446	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
999541012447	active site
999541012448	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
999541012449	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
999541012450	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
999541012451	active site
999541012452	purine riboside binding site [chemical binding]; other site
999541012453	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
999541012454	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
999541012455	XdhC Rossmann domain; Region: XdhC_C; pfam13478
999541012456	disulfide bond formation protein B; Provisional; Region: PRK02110
999541012457	amidase; Provisional; Region: PRK07056
999541012458	Amidase; Region: Amidase; cl11426
999541012459	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
999541012460	Peptidase C26; Region: Peptidase_C26; pfam07722
999541012461	catalytic triad [active]
999541012462	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
999541012463	citrate-proton symporter; Provisional; Region: PRK15075
999541012464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541012465	putative substrate translocation pore; other site
999541012466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541012467	TPR motif; other site
999541012468	binding surface
999541012469	TPR repeat; Region: TPR_11; pfam13414
999541012470	TPR repeat; Region: TPR_11; pfam13414
999541012471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541012472	binding surface
999541012473	TPR motif; other site
999541012474	Tetratricopeptide repeat; Region: TPR_16; pfam13432
999541012475	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541012476	hypothetical protein; Provisional; Region: PRK06184
999541012477	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541012478	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
999541012479	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
999541012480	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541012481	catalytic loop [active]
999541012482	iron binding site [ion binding]; other site
999541012483	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
999541012484	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
999541012485	[4Fe-4S] binding site [ion binding]; other site
999541012486	molybdopterin cofactor binding site; other site
999541012487	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
999541012488	molybdopterin cofactor binding site; other site
999541012489	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
999541012490	putative dimer interface [polypeptide binding]; other site
999541012491	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
999541012492	SLBB domain; Region: SLBB; pfam10531
999541012493	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
999541012494	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
999541012495	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
999541012496	putative dimer interface [polypeptide binding]; other site
999541012497	[2Fe-2S] cluster binding site [ion binding]; other site
999541012498	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
999541012499	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
999541012500	PBP superfamily domain; Region: PBP_like; pfam12727
999541012501	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541012502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541012503	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541012504	dimerization interface [polypeptide binding]; other site
999541012505	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
999541012506	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
999541012507	ATP-dependent DNA ligase; Validated; Region: PRK09247
999541012508	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
999541012509	active site
999541012510	DNA binding site [nucleotide binding]
999541012511	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
999541012512	DNA binding site [nucleotide binding]
999541012513	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
999541012514	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541012515	ATP binding site [chemical binding]; other site
999541012516	putative Mg++ binding site [ion binding]; other site
999541012517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541012518	nucleotide binding region [chemical binding]; other site
999541012519	ATP-binding site [chemical binding]; other site
999541012520	DEAD/H associated; Region: DEAD_assoc; pfam08494
999541012521	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
999541012522	putative active site [active]
999541012523	putative metal binding site [ion binding]; other site
999541012524	phosphoglycolate phosphatase; Provisional; Region: PRK13222
999541012525	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541012526	motif II; other site
999541012527	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
999541012528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541012529	S-adenosylmethionine binding site [chemical binding]; other site
999541012530	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541012531	ligand binding site [chemical binding]; other site
999541012532	DNA gyrase subunit A; Validated; Region: PRK05560
999541012533	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
999541012534	CAP-like domain; other site
999541012535	active site
999541012536	primary dimer interface [polypeptide binding]; other site
999541012537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012538	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012539	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012540	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012541	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012542	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541012543	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
999541012544	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
999541012545	homodimer interface [polypeptide binding]; other site
999541012546	substrate-cofactor binding pocket; other site
999541012547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541012548	catalytic residue [active]
999541012549	Chorismate mutase type II; Region: CM_2; smart00830
999541012550	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
999541012551	Prephenate dehydratase; Region: PDT; pfam00800
999541012552	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
999541012553	putative L-Phe binding site [chemical binding]; other site
999541012554	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
999541012555	prephenate dehydrogenase; Validated; Region: PRK08507
999541012556	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
999541012557	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
999541012558	hinge; other site
999541012559	active site
999541012560	cytidylate kinase; Provisional; Region: cmk; PRK00023
999541012561	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
999541012562	CMP-binding site; other site
999541012563	The sites determining sugar specificity; other site
999541012564	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
999541012565	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
999541012566	RNA binding site [nucleotide binding]; other site
999541012567	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
999541012568	RNA binding site [nucleotide binding]; other site
999541012569	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
999541012570	RNA binding site [nucleotide binding]; other site
999541012571	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
999541012572	RNA binding site [nucleotide binding]; other site
999541012573	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
999541012574	RNA binding site [nucleotide binding]; other site
999541012575	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
999541012576	RNA binding site [nucleotide binding]; other site
999541012577	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
999541012578	IHF dimer interface [polypeptide binding]; other site
999541012579	IHF - DNA interface [nucleotide binding]; other site
999541012580	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
999541012581	tetratricopeptide repeat protein; Provisional; Region: PRK11788
999541012582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541012583	binding surface
999541012584	TPR motif; other site
999541012585	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
999541012586	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
999541012587	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
999541012588	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
999541012589	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
999541012590	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541012591	putative ribose interaction site [chemical binding]; other site
999541012592	putative ADP binding site [chemical binding]; other site
999541012593	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
999541012594	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
999541012595	NADP binding site [chemical binding]; other site
999541012596	homopentamer interface [polypeptide binding]; other site
999541012597	substrate binding site [chemical binding]; other site
999541012598	active site
999541012599	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
999541012600	cysteine synthase B; Region: cysM; TIGR01138
999541012601	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
999541012602	dimer interface [polypeptide binding]; other site
999541012603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541012604	catalytic residue [active]
999541012605	Transglycosylase SLT domain; Region: SLT_2; pfam13406
999541012606	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541012607	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541012608	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
999541012609	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
999541012610	putative active site [active]
999541012611	Zn binding site [ion binding]; other site
999541012612	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
999541012613	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541012614	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
999541012615	nucleophilic elbow; other site
999541012616	catalytic triad; other site
999541012617	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
999541012618	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
999541012619	Walker A/P-loop; other site
999541012620	ATP binding site [chemical binding]; other site
999541012621	Q-loop/lid; other site
999541012622	ABC transporter signature motif; other site
999541012623	Walker B; other site
999541012624	D-loop; other site
999541012625	H-loop/switch region; other site
999541012626	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
999541012627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541012628	dimer interface [polypeptide binding]; other site
999541012629	conserved gate region; other site
999541012630	ABC-ATPase subunit interface; other site
999541012631	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
999541012632	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
999541012633	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
999541012634	Ligand binding site [chemical binding]; other site
999541012635	Electron transfer flavoprotein domain; Region: ETF; pfam01012
999541012636	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
999541012637	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
999541012638	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
999541012639	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
999541012640	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
999541012641	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541012642	active site
999541012643	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
999541012644	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
999541012645	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541012646	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541012647	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
999541012648	AsnC family; Region: AsnC_trans_reg; pfam01037
999541012649	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
999541012650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541012651	FeS/SAM binding site; other site
999541012652	Domain of unknown function (DUF373); Region: DUF373; cl12079
999541012653	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
999541012654	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
999541012655	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
999541012656	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
999541012657	RimM N-terminal domain; Region: RimM; pfam01782
999541012658	PRC-barrel domain; Region: PRC; pfam05239
999541012659	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
999541012660	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
999541012661	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
999541012662	putative active site [active]
999541012663	putative CoA binding site [chemical binding]; other site
999541012664	nudix motif; other site
999541012665	metal binding site [ion binding]; metal-binding site
999541012666	CobD/CbiB family protein; Provisional; Region: PRK07630
999541012667	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
999541012668	GTPase RsgA; Reviewed; Region: PRK00098
999541012669	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
999541012670	RNA binding site [nucleotide binding]; other site
999541012671	homodimer interface [polypeptide binding]; other site
999541012672	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
999541012673	GTPase/Zn-binding domain interface [polypeptide binding]; other site
999541012674	GTP/Mg2+ binding site [chemical binding]; other site
999541012675	G4 box; other site
999541012676	G5 box; other site
999541012677	G1 box; other site
999541012678	Switch I region; other site
999541012679	G2 box; other site
999541012680	G3 box; other site
999541012681	Switch II region; other site
999541012682	Peptidase family M48; Region: Peptidase_M48; pfam01435
999541012683	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
999541012684	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
999541012685	catalytic site [active]
999541012686	putative active site [active]
999541012687	putative substrate binding site [chemical binding]; other site
999541012688	dimer interface [polypeptide binding]; other site
999541012689	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
999541012690	MPT binding site; other site
999541012691	trimer interface [polypeptide binding]; other site
999541012692	hypothetical protein; Provisional; Region: PRK05255
999541012693	peptidase PmbA; Provisional; Region: PRK11040
999541012694	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
999541012695	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
999541012696	folate binding site [chemical binding]; other site
999541012697	NADP+ binding site [chemical binding]; other site
999541012698	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541012699	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541012700	Walker A motif; other site
999541012701	ATP binding site [chemical binding]; other site
999541012702	Walker B motif; other site
999541012703	arginine finger; other site
999541012704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541012705	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541012706	Walker A motif; other site
999541012707	ATP binding site [chemical binding]; other site
999541012708	Walker B motif; other site
999541012709	arginine finger; other site
999541012710	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541012711	thymidylate synthase; Provisional; Region: thyA; PRK13821
999541012712	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
999541012713	dimerization interface [polypeptide binding]; other site
999541012714	active site
999541012715	FecR protein; Region: FecR; pfam04773
999541012716	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541012717	dimerization interface [polypeptide binding]; other site
999541012718	putative DNA binding site [nucleotide binding]; other site
999541012719	putative Zn2+ binding site [ion binding]; other site
999541012720	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
999541012721	fumarate hydratase; Reviewed; Region: fumC; PRK00485
999541012722	Class II fumarases; Region: Fumarase_classII; cd01362
999541012723	active site
999541012724	tetramer interface [polypeptide binding]; other site
999541012725	multidrug efflux protein; Reviewed; Region: PRK01766
999541012726	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
999541012727	cation binding site [ion binding]; other site
999541012728	S4 domain; Region: S4_2; pfam13275
999541012729	Protein of unknown function (DUF4088); Region: DUF4088; pfam13317
999541012730	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
999541012731	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
999541012732	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541012733	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541012734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
999541012735	CreA protein; Region: CreA; pfam05981
999541012736	Ferredoxin [Energy production and conversion]; Region: COG1146
999541012737	4Fe-4S binding domain; Region: Fer4; cl02805
999541012738	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
999541012739	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
999541012740	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
999541012741	active site
999541012742	Uncharacterized conserved protein [Function unknown]; Region: COG1556
999541012743	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
999541012744	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541012745	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
999541012746	dimerization interface [polypeptide binding]; other site
999541012747	ligand binding site [chemical binding]; other site
999541012748	NADP binding site [chemical binding]; other site
999541012749	catalytic site [active]
999541012750	RmuC family; Region: RmuC; pfam02646
999541012751	putative acetyltransferase; Provisional; Region: PRK03624
999541012752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541012753	Coenzyme A binding pocket [chemical binding]; other site
999541012754	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
999541012755	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
999541012756	dimer interface [polypeptide binding]; other site
999541012757	putative functional site; other site
999541012758	putative MPT binding site; other site
999541012759	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
999541012760	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
999541012761	GTP binding site; other site
999541012762	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
999541012763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541012764	FeS/SAM binding site; other site
999541012765	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
999541012766	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
999541012767	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
999541012768	homodimer interface [polypeptide binding]; other site
999541012769	oligonucleotide binding site [chemical binding]; other site
999541012770	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
999541012771	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541012772	RNA binding surface [nucleotide binding]; other site
999541012773	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
999541012774	active site
999541012775	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
999541012776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541012777	motif II; other site
999541012778	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
999541012779	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
999541012780	iron-sulfur cluster [ion binding]; other site
999541012781	[2Fe-2S] cluster binding site [ion binding]; other site
999541012782	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
999541012783	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
999541012784	tandem repeat interface [polypeptide binding]; other site
999541012785	oligomer interface [polypeptide binding]; other site
999541012786	active site residues [active]
999541012787	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
999541012788	putative SAM binding site [chemical binding]; other site
999541012789	homodimer interface [polypeptide binding]; other site
999541012790	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
999541012791	active site
999541012792	dimer interface [polypeptide binding]; other site
999541012793	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
999541012794	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
999541012795	putative phosphate acyltransferase; Provisional; Region: PRK05331
999541012796	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
999541012797	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
999541012798	dimer interface [polypeptide binding]; other site
999541012799	active site
999541012800	CoA binding pocket [chemical binding]; other site
999541012801	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
999541012802	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541012803	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541012804	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
999541012805	NAD(P) binding site [chemical binding]; other site
999541012806	homotetramer interface [polypeptide binding]; other site
999541012807	homodimer interface [polypeptide binding]; other site
999541012808	active site
999541012809	acyl carrier protein; Provisional; Region: acpP; PRK00982
999541012810	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
999541012811	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
999541012812	dimer interface [polypeptide binding]; other site
999541012813	active site
999541012814	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
999541012815	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541012816	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541012817	DNA binding residues [nucleotide binding]
999541012818	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
999541012819	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
999541012820	anti-sigma E factor; Provisional; Region: rseB; PRK09455
999541012821	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
999541012822	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
999541012823	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541012824	protein binding site [polypeptide binding]; other site
999541012825	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541012826	protein binding site [polypeptide binding]; other site
999541012827	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
999541012828	GTP-binding protein LepA; Provisional; Region: PRK05433
999541012829	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
999541012830	G1 box; other site
999541012831	putative GEF interaction site [polypeptide binding]; other site
999541012832	GTP/Mg2+ binding site [chemical binding]; other site
999541012833	Switch I region; other site
999541012834	G2 box; other site
999541012835	G3 box; other site
999541012836	Switch II region; other site
999541012837	G4 box; other site
999541012838	G5 box; other site
999541012839	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
999541012840	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
999541012841	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
999541012842	signal peptidase I; Provisional; Region: PRK10861
999541012843	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
999541012844	Catalytic site [active]
999541012845	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
999541012846	ribonuclease III; Reviewed; Region: PRK12372
999541012847	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
999541012848	dimerization interface [polypeptide binding]; other site
999541012849	active site
999541012850	metal binding site [ion binding]; metal-binding site
999541012851	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
999541012852	GTPase Era; Reviewed; Region: era; PRK00089
999541012853	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
999541012854	G1 box; other site
999541012855	GTP/Mg2+ binding site [chemical binding]; other site
999541012856	Switch I region; other site
999541012857	G2 box; other site
999541012858	Switch II region; other site
999541012859	G3 box; other site
999541012860	G4 box; other site
999541012861	G5 box; other site
999541012862	KH domain; Region: KH_2; pfam07650
999541012863	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
999541012864	Recombination protein O N terminal; Region: RecO_N; pfam11967
999541012865	Recombination protein O C terminal; Region: RecO_C; pfam02565
999541012866	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
999541012867	active site
999541012868	hydrophilic channel; other site
999541012869	dimerization interface [polypeptide binding]; other site
999541012870	catalytic residues [active]
999541012871	active site lid [active]
999541012872	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
999541012873	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
999541012874	beta-hexosaminidase; Provisional; Region: PRK05337
999541012875	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541012876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541012877	active site
999541012878	phosphorylation site [posttranslational modification]
999541012879	intermolecular recognition site; other site
999541012880	dimerization interface [polypeptide binding]; other site
999541012881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541012882	Walker A motif; other site
999541012883	ATP binding site [chemical binding]; other site
999541012884	Walker B motif; other site
999541012885	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541012886	elongation factor P; Validated; Region: PRK00529
999541012887	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
999541012888	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
999541012889	RNA binding site [nucleotide binding]; other site
999541012890	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
999541012891	RNA binding site [nucleotide binding]; other site
999541012892	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
999541012893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
999541012894	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
999541012895	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
999541012896	GIY-YIG motif/motif A; other site
999541012897	active site
999541012898	catalytic site [active]
999541012899	putative DNA binding site [nucleotide binding]; other site
999541012900	metal binding site [ion binding]; metal-binding site
999541012901	UvrB/uvrC motif; Region: UVR; pfam02151
999541012902	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
999541012903	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
999541012904	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
999541012905	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541012906	active site
999541012907	DNA binding site [nucleotide binding]
999541012908	Int/Topo IB signature motif; other site
999541012909	AAA domain; Region: AAA_21; pfam13304
999541012910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
999541012911	ABC transporter signature motif; other site
999541012912	Walker B; other site
999541012913	D-loop; other site
999541012914	H-loop/switch region; other site
999541012915	Helix-turn-helix domain; Region: HTH_17; pfam12728
999541012916	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
999541012917	ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554
999541012918	Short C-terminal domain; Region: SHOCT; pfam09851
999541012919	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
999541012920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
999541012921	sequence-specific DNA binding site [nucleotide binding]; other site
999541012922	salt bridge; other site
999541012923	Predicted transcriptional regulator [Transcription]; Region: COG2932
999541012924	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
999541012925	Catalytic site [active]
999541012926	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
999541012927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
999541012928	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
999541012929	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
999541012930	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
999541012931	Virulence-associated protein E; Region: VirE; pfam05272
999541012932	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
999541012933	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
999541012934	Zn binding sites [ion binding]; other site
999541012935	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
999541012936	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
999541012937	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
999541012938	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
999541012939	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
999541012940	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
999541012941	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
999541012942	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
999541012943	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
999541012944	Phage-related minor tail protein [Function unknown]; Region: COG5281
999541012945	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
999541012946	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
999541012947	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
999541012948	NlpC/P60 family; Region: NLPC_P60; cl17555
999541012949	Putative phage tail protein; Region: Phage-tail_3; pfam13550
999541012950	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
999541012951	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
999541012952	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
999541012953	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
999541012954	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
999541012955	Domain of unknown function (DUF955); Region: DUF955; cl01076
999541012956	Helix-turn-helix domain; Region: HTH_19; pfam12844
999541012957	non-specific DNA binding site [nucleotide binding]; other site
999541012958	salt bridge; other site
999541012959	sequence-specific DNA binding site [nucleotide binding]; other site
999541012960	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541012961	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541012962	non-specific DNA binding site [nucleotide binding]; other site
999541012963	salt bridge; other site
999541012964	sequence-specific DNA binding site [nucleotide binding]; other site
999541012965	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
999541012966	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541012967	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
999541012968	Walker A/P-loop; other site
999541012969	ATP binding site [chemical binding]; other site
999541012970	Q-loop/lid; other site
999541012971	ABC transporter signature motif; other site
999541012972	Walker B; other site
999541012973	D-loop; other site
999541012974	H-loop/switch region; other site
999541012975	PAAR motif; Region: PAAR_motif; pfam05488
999541012976	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
999541012977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541012978	S-adenosylmethionine binding site [chemical binding]; other site
999541012979	Ferredoxin [Energy production and conversion]; Region: COG1146
999541012980	4Fe-4S binding domain; Region: Fer4; cl02805
999541012981	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
999541012982	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541012983	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541012984	DNA binding residues [nucleotide binding]
999541012985	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
999541012986	GAF domain; Region: GAF_2; pfam13185
999541012987	LysR family transcriptional regulator; Provisional; Region: PRK14997
999541012988	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541012989	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541012990	dimerization interface [polypeptide binding]; other site
999541012991	Pirin-related protein [General function prediction only]; Region: COG1741
999541012992	Pirin; Region: Pirin; pfam02678
999541012993	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
999541012994	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541012995	Coenzyme A binding pocket [chemical binding]; other site
999541012996	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
999541012997	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
999541012998	Cu(I) binding site [ion binding]; other site
999541012999	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
999541013000	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
999541013001	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
999541013002	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
999541013003	active site
999541013004	homotetramer interface [polypeptide binding]; other site
999541013005	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
999541013006	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541013007	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
999541013008	Walker A/P-loop; other site
999541013009	ATP binding site [chemical binding]; other site
999541013010	Q-loop/lid; other site
999541013011	ABC transporter signature motif; other site
999541013012	Walker B; other site
999541013013	D-loop; other site
999541013014	H-loop/switch region; other site
999541013015	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
999541013016	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541013017	putative ADP-binding pocket [chemical binding]; other site
999541013018	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
999541013019	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541013020	DNA-binding site [nucleotide binding]; DNA binding site
999541013021	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
999541013022	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541013023	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541013024	extended (e) SDRs; Region: SDR_e; cd08946
999541013025	NAD(P) binding site [chemical binding]; other site
999541013026	active site
999541013027	substrate binding site [chemical binding]; other site
999541013028	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
999541013029	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541013030	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541013031	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541013032	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541013033	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541013034	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
999541013035	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
999541013036	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
999541013037	pyridoxamine kinase; Validated; Region: PRK05756
999541013038	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
999541013039	dimer interface [polypeptide binding]; other site
999541013040	pyridoxal binding site [chemical binding]; other site
999541013041	ATP binding site [chemical binding]; other site
999541013042	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541013043	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
999541013044	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
999541013045	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
999541013046	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
999541013047	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
999541013048	ligand binding site; other site
999541013049	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
999541013050	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
999541013051	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
999541013052	B12 binding site [chemical binding]; other site
999541013053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541013054	FeS/SAM binding site; other site
999541013055	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
999541013056	putative active site [active]
999541013057	YdjC motif; other site
999541013058	Mg binding site [ion binding]; other site
999541013059	putative homodimer interface [polypeptide binding]; other site
999541013060	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
999541013061	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
999541013062	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541013063	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541013064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013065	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541013066	Coenzyme A binding pocket [chemical binding]; other site
999541013067	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541013068	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541013069	putative DNA binding site [nucleotide binding]; other site
999541013070	putative Zn2+ binding site [ion binding]; other site
999541013071	MarR family; Region: MarR_2; cl17246
999541013072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541013073	Coenzyme A binding pocket [chemical binding]; other site
999541013074	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541013075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013076	dimer interface [polypeptide binding]; other site
999541013077	conserved gate region; other site
999541013078	putative PBP binding loops; other site
999541013079	ABC-ATPase subunit interface; other site
999541013080	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541013081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013082	dimer interface [polypeptide binding]; other site
999541013083	conserved gate region; other site
999541013084	putative PBP binding loops; other site
999541013085	ABC-ATPase subunit interface; other site
999541013086	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
999541013087	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541013088	Walker A/P-loop; other site
999541013089	ATP binding site [chemical binding]; other site
999541013090	Q-loop/lid; other site
999541013091	ABC transporter signature motif; other site
999541013092	Walker B; other site
999541013093	D-loop; other site
999541013094	H-loop/switch region; other site
999541013095	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541013096	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
999541013097	conserved cys residue [active]
999541013098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013100	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
999541013101	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541013102	inhibitor-cofactor binding pocket; inhibition site
999541013103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541013104	catalytic residue [active]
999541013105	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
999541013106	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
999541013107	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
999541013108	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
999541013109	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
999541013110	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
999541013111	NAD(P) binding site [chemical binding]; other site
999541013112	catalytic residues [active]
999541013113	succinylarginine dihydrolase; Provisional; Region: PRK13281
999541013114	succinylglutamate desuccinylase; Provisional; Region: PRK05324
999541013115	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
999541013116	active site
999541013117	Zn binding site [ion binding]; other site
999541013118	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
999541013119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541013120	substrate binding pocket [chemical binding]; other site
999541013121	membrane-bound complex binding site; other site
999541013122	hinge residues; other site
999541013123	HDOD domain; Region: HDOD; pfam08668
999541013124	PAS fold; Region: PAS_4; pfam08448
999541013125	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
999541013126	putative active site [active]
999541013127	heme pocket [chemical binding]; other site
999541013128	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541013129	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541013130	metal binding site [ion binding]; metal-binding site
999541013131	active site
999541013132	I-site; other site
999541013133	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541013134	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
999541013135	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
999541013136	catalytic triad [active]
999541013137	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
999541013138	NADH(P)-binding; Region: NAD_binding_10; pfam13460
999541013139	NAD(P) binding site [chemical binding]; other site
999541013140	putative active site [active]
999541013141	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541013142	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541013143	Coenzyme A binding pocket [chemical binding]; other site
999541013144	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
999541013145	Protein export membrane protein; Region: SecD_SecF; cl14618
999541013146	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
999541013147	Protein export membrane protein; Region: SecD_SecF; cl14618
999541013148	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
999541013149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541013150	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541013151	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541013152	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541013153	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
999541013154	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
999541013155	Predicted transcriptional regulator [Transcription]; Region: COG1959
999541013156	Transcriptional regulator; Region: Rrf2; pfam02082
999541013157	NAD(P) binding site [chemical binding]; other site
999541013158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541013159	NADH(P)-binding; Region: NAD_binding_10; pfam13460
999541013160	active site
999541013161	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541013162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541013163	putative DNA binding site [nucleotide binding]; other site
999541013164	putative Zn2+ binding site [ion binding]; other site
999541013165	AsnC family; Region: AsnC_trans_reg; pfam01037
999541013166	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
999541013167	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
999541013168	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541013169	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
999541013170	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
999541013171	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
999541013172	Family description; Region: UvrD_C_2; pfam13538
999541013173	AAA domain; Region: AAA_30; pfam13604
999541013174	Family description; Region: UvrD_C_2; pfam13538
999541013175	hypothetical protein; Provisional; Region: PRK09256
999541013176	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541013177	EamA-like transporter family; Region: EamA; pfam00892
999541013178	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
999541013179	ThiC-associated domain; Region: ThiC-associated; pfam13667
999541013180	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
999541013181	EamA-like transporter family; Region: EamA; pfam00892
999541013182	EamA-like transporter family; Region: EamA; cl17759
999541013183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013184	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541013185	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
999541013186	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541013187	active site
999541013188	metal binding site [ion binding]; metal-binding site
999541013189	hexamer interface [polypeptide binding]; other site
999541013190	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
999541013191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541013192	Walker A/P-loop; other site
999541013193	ATP binding site [chemical binding]; other site
999541013194	Q-loop/lid; other site
999541013195	ABC transporter signature motif; other site
999541013196	Walker B; other site
999541013197	D-loop; other site
999541013198	H-loop/switch region; other site
999541013199	TOBE domain; Region: TOBE_2; pfam08402
999541013200	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541013201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013202	putative PBP binding loops; other site
999541013203	ABC-ATPase subunit interface; other site
999541013204	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
999541013205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013206	dimer interface [polypeptide binding]; other site
999541013207	conserved gate region; other site
999541013208	putative PBP binding loops; other site
999541013209	ABC-ATPase subunit interface; other site
999541013210	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
999541013211	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541013212	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541013213	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541013214	DNA binding site [nucleotide binding]
999541013215	domain linker motif; other site
999541013216	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
999541013217	putative dimerization interface [polypeptide binding]; other site
999541013218	putative ligand binding site [chemical binding]; other site
999541013219	Domain of unknown function (DUF932); Region: DUF932; cl12129
999541013220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541013221	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541013222	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541013223	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541013224	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541013225	putative transposase OrfB; Reviewed; Region: PHA02517
999541013226	Integrase core domain; Region: rve; pfam00665
999541013227	Integrase core domain; Region: rve_3; pfam13683
999541013228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541013229	HTH-like domain; Region: HTH_21; pfam13276
999541013230	Integrase core domain; Region: rve; pfam00665
999541013231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541013232	Transposase; Region: HTH_Tnp_1; cl17663
999541013233	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
999541013234	active site
999541013235	catalytic site [active]
999541013236	substrate binding site [chemical binding]; other site
999541013237	Tannase and feruloyl esterase; Region: Tannase; pfam07519
999541013238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013239	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541013240	dimerization interface [polypeptide binding]; other site
999541013241	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
999541013242	EamA-like transporter family; Region: EamA; pfam00892
999541013243	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
999541013244	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
999541013245	peptidase domain interface [polypeptide binding]; other site
999541013246	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
999541013247	active site
999541013248	catalytic triad [active]
999541013249	calcium binding site [ion binding]; other site
999541013250	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541013251	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013252	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013253	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541013254	putative effector binding pocket; other site
999541013255	dimerization interface [polypeptide binding]; other site
999541013256	HD domain; Region: HD_3; pfam13023
999541013257	TPR repeat; Region: TPR_11; pfam13414
999541013258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541013259	binding surface
999541013260	TPR motif; other site
999541013261	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013263	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
999541013264	putative effector binding pocket; other site
999541013265	putative dimerization interface [polypeptide binding]; other site
999541013266	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
999541013267	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
999541013268	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
999541013269	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
999541013270	FAD binding pocket [chemical binding]; other site
999541013271	FAD binding motif [chemical binding]; other site
999541013272	phosphate binding motif [ion binding]; other site
999541013273	beta-alpha-beta structure motif; other site
999541013274	NAD binding pocket [chemical binding]; other site
999541013275	Heme binding  pocket [chemical binding]; other site
999541013276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541013277	catalytic loop [active]
999541013278	iron binding site [ion binding]; other site
999541013279	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541013280	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541013281	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
999541013282	putative N-terminal domain interface [polypeptide binding]; other site
999541013283	putative dimer interface [polypeptide binding]; other site
999541013284	putative substrate binding pocket (H-site) [chemical binding]; other site
999541013285	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
999541013286	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541013287	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541013288	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
999541013289	PAAR motif; Region: PAAR_motif; pfam05488
999541013290	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541013291	RHS Repeat; Region: RHS_repeat; pfam05593
999541013292	RHS Repeat; Region: RHS_repeat; pfam05593
999541013293	RHS Repeat; Region: RHS_repeat; pfam05593
999541013294	RHS Repeat; Region: RHS_repeat; pfam05593
999541013295	RHS Repeat; Region: RHS_repeat; pfam05593
999541013296	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541013297	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
999541013298	Domain of unknown function (DUF4284); Region: DUF4284; pfam14112
999541013299	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
999541013300	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
999541013301	tetramer interface [polypeptide binding]; other site
999541013302	heme binding pocket [chemical binding]; other site
999541013303	NADPH binding site [chemical binding]; other site
999541013304	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
999541013305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541013306	S-adenosylmethionine binding site [chemical binding]; other site
999541013307	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
999541013308	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
999541013309	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541013310	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541013311	DNA binding residues [nucleotide binding]
999541013312	SnoaL-like domain; Region: SnoaL_4; cl17707
999541013313	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
999541013314	Uncharacterized conserved protein [Function unknown]; Region: COG2128
999541013315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013317	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541013318	putative effector binding pocket; other site
999541013319	dimerization interface [polypeptide binding]; other site
999541013320	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541013321	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
999541013322	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
999541013323	DXD motif; other site
999541013324	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
999541013325	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
999541013326	CHRD domain; Region: CHRD; pfam07452
999541013327	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
999541013328	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541013329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541013330	DNA binding residues [nucleotide binding]
999541013331	TIGR03118 family protein; Region: PEPCTERM_chp_1
999541013332	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
999541013333	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
999541013334	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
999541013335	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
999541013336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541013337	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541013338	PRC-barrel domain; Region: PRC; pfam05239
999541013339	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
999541013340	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
999541013341	putative homodimer interface [polypeptide binding]; other site
999541013342	putative DNA binding site [nucleotide binding]; other site
999541013343	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
999541013344	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
999541013345	active site
999541013346	DNA binding site [nucleotide binding]
999541013347	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
999541013348	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
999541013349	DNA binding site [nucleotide binding]
999541013350	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
999541013351	nucleotide binding site [chemical binding]; other site
999541013352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541013353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541013354	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541013355	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
999541013356	active site
999541013357	metal binding site [ion binding]; metal-binding site
999541013358	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
999541013359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541013360	S-adenosylmethionine binding site [chemical binding]; other site
999541013361	putative S-transferase; Provisional; Region: PRK11752
999541013362	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
999541013363	C-terminal domain interface [polypeptide binding]; other site
999541013364	GSH binding site (G-site) [chemical binding]; other site
999541013365	dimer interface [polypeptide binding]; other site
999541013366	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
999541013367	dimer interface [polypeptide binding]; other site
999541013368	N-terminal domain interface [polypeptide binding]; other site
999541013369	active site
999541013370	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
999541013371	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541013372	putative NAD(P) binding site [chemical binding]; other site
999541013373	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
999541013374	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
999541013375	tetrameric interface [polypeptide binding]; other site
999541013376	NAD binding site [chemical binding]; other site
999541013377	catalytic residues [active]
999541013378	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013379	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013380	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541013381	putative effector binding pocket; other site
999541013382	dimerization interface [polypeptide binding]; other site
999541013383	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
999541013384	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541013385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541013387	dimerization interface [polypeptide binding]; other site
999541013388	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541013389	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
999541013390	active site
999541013391	catalytic residues [active]
999541013392	metal binding site [ion binding]; metal-binding site
999541013393	hypothetical protein; Provisional; Region: PRK05463
999541013394	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541013395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013396	putative substrate translocation pore; other site
999541013397	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
999541013398	putative active site [active]
999541013399	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
999541013400	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
999541013401	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
999541013402	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541013403	putative metal binding site [ion binding]; other site
999541013404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013405	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
999541013406	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
999541013407	putative dimerization interface [polypeptide binding]; other site
999541013408	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541013409	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541013410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013411	putative substrate translocation pore; other site
999541013412	MarR family; Region: MarR_2; cl17246
999541013413	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541013414	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541013415	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
999541013416	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
999541013417	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
999541013418	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
999541013419	Isochorismatase family; Region: Isochorismatase; pfam00857
999541013420	catalytic triad [active]
999541013421	conserved cis-peptide bond; other site
999541013422	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541013423	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
999541013424	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541013425	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
999541013426	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
999541013427	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541013428	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
999541013429	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
999541013430	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
999541013431	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541013432	Cytochrome c; Region: Cytochrom_C; pfam00034
999541013433	XdhC Rossmann domain; Region: XdhC_C; pfam13478
999541013434	manganese transport protein MntH; Reviewed; Region: PRK00701
999541013435	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541013436	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541013437	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
999541013438	active site
999541013439	HIGH motif; other site
999541013440	nucleotide binding site [chemical binding]; other site
999541013441	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541013442	active site
999541013443	KMSKS motif; other site
999541013444	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
999541013445	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
999541013446	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
999541013447	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
999541013448	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
999541013449	trimer interface [polypeptide binding]; other site
999541013450	active site
999541013451	dihydroorotase; Validated; Region: PRK09060
999541013452	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
999541013453	active site
999541013454	Predicted dehydrogenase [General function prediction only]; Region: COG0579
999541013455	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541013456	transcriptional activator TtdR; Provisional; Region: PRK09801
999541013457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013458	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541013459	dimerization interface [polypeptide binding]; other site
999541013460	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541013461	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
999541013462	putative active site pocket [active]
999541013463	metal binding site [ion binding]; metal-binding site
999541013464	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
999541013465	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541013466	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013468	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
999541013469	putative substrate binding pocket [chemical binding]; other site
999541013470	putative dimerization interface [polypeptide binding]; other site
999541013471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541013472	C factor cell-cell signaling protein; Provisional; Region: PRK09009
999541013473	NAD(P) binding site [chemical binding]; other site
999541013474	active site
999541013475	Uncharacterized conserved protein [Function unknown]; Region: COG2128
999541013476	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541013477	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541013478	non-specific DNA binding site [nucleotide binding]; other site
999541013479	salt bridge; other site
999541013480	sequence-specific DNA binding site [nucleotide binding]; other site
999541013481	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
999541013482	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541013483	active site
999541013484	drug efflux system protein MdtG; Provisional; Region: PRK09874
999541013485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013486	putative substrate translocation pore; other site
999541013487	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
999541013488	Predicted ATPase [General function prediction only]; Region: COG1485
999541013489	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
999541013490	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
999541013491	nudix motif; other site
999541013492	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
999541013493	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
999541013494	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
999541013495	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
999541013496	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541013497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013498	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541013499	putative substrate translocation pore; other site
999541013500	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013501	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
999541013502	putative dimerization interface [polypeptide binding]; other site
999541013503	putative substrate binding pocket [chemical binding]; other site
999541013504	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
999541013505	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
999541013506	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
999541013507	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541013508	motif II; other site
999541013509	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541013510	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541013511	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541013512	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
999541013513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013514	putative substrate translocation pore; other site
999541013515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013516	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541013517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013518	putative substrate translocation pore; other site
999541013519	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541013520	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541013521	active site
999541013522	catalytic tetrad [active]
999541013523	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
999541013524	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
999541013525	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541013526	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
999541013527	putative dimer interface [polypeptide binding]; other site
999541013528	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541013529	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
999541013530	putative dimer interface [polypeptide binding]; other site
999541013531	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
999541013532	active site
999541013533	substrate-binding site [chemical binding]; other site
999541013534	metal-binding site [ion binding]
999541013535	GTP binding site [chemical binding]; other site
999541013536	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
999541013537	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
999541013538	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541013539	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541013540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013541	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013542	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541013543	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013545	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541013546	dimerization interface [polypeptide binding]; other site
999541013547	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
999541013548	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
999541013549	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
999541013550	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
999541013551	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
999541013552	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
999541013553	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
999541013554	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541013555	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
999541013556	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541013557	putative active site [active]
999541013558	catalytic site [active]
999541013559	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
999541013560	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541013561	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541013562	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
999541013563	C-terminal domain interface [polypeptide binding]; other site
999541013564	GSH binding site (G-site) [chemical binding]; other site
999541013565	dimer interface [polypeptide binding]; other site
999541013566	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541013567	N-terminal domain interface [polypeptide binding]; other site
999541013568	proline/glycine betaine transporter; Provisional; Region: PRK10642
999541013569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013570	putative substrate translocation pore; other site
999541013571	hypothetical protein; Provisional; Region: PRK02237
999541013572	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
999541013573	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
999541013574	active site
999541013575	catalytic site [active]
999541013576	substrate binding site [chemical binding]; other site
999541013577	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
999541013578	RNA/DNA hybrid binding site [nucleotide binding]; other site
999541013579	active site
999541013580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541013581	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
999541013582	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541013583	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541013584	catalytic residue [active]
999541013585	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541013586	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541013587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013588	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541013589	putative substrate translocation pore; other site
999541013590	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
999541013591	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
999541013592	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
999541013593	catalytic site [active]
999541013594	subunit interface [polypeptide binding]; other site
999541013595	leucine export protein LeuE; Provisional; Region: PRK10958
999541013596	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
999541013597	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541013598	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
999541013599	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
999541013600	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541013601	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541013602	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
999541013603	IMP binding site; other site
999541013604	dimer interface [polypeptide binding]; other site
999541013605	interdomain contacts; other site
999541013606	partial ornithine binding site; other site
999541013607	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
999541013608	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
999541013609	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
999541013610	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
999541013611	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
999541013612	FtsJ-like methyltransferase; Region: FtsJ; cl17430
999541013613	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
999541013614	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
999541013615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541013616	Walker A motif; other site
999541013617	ATP binding site [chemical binding]; other site
999541013618	Walker B motif; other site
999541013619	arginine finger; other site
999541013620	Peptidase family M41; Region: Peptidase_M41; pfam01434
999541013621	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
999541013622	dihydropteroate synthase; Region: DHPS; TIGR01496
999541013623	substrate binding pocket [chemical binding]; other site
999541013624	dimer interface [polypeptide binding]; other site
999541013625	inhibitor binding site; inhibition site
999541013626	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
999541013627	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
999541013628	active site
999541013629	substrate binding site [chemical binding]; other site
999541013630	metal binding site [ion binding]; metal-binding site
999541013631	PBP superfamily domain; Region: PBP_like_2; cl17296
999541013632	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
999541013633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013634	dimer interface [polypeptide binding]; other site
999541013635	conserved gate region; other site
999541013636	putative PBP binding loops; other site
999541013637	ABC-ATPase subunit interface; other site
999541013638	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
999541013639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541013640	dimer interface [polypeptide binding]; other site
999541013641	conserved gate region; other site
999541013642	putative PBP binding loops; other site
999541013643	ABC-ATPase subunit interface; other site
999541013644	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
999541013645	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
999541013646	Walker A/P-loop; other site
999541013647	ATP binding site [chemical binding]; other site
999541013648	Q-loop/lid; other site
999541013649	ABC transporter signature motif; other site
999541013650	Walker B; other site
999541013651	D-loop; other site
999541013652	H-loop/switch region; other site
999541013653	transcriptional regulator PhoU; Provisional; Region: PRK11115
999541013654	PhoU domain; Region: PhoU; pfam01895
999541013655	PhoU domain; Region: PhoU; pfam01895
999541013656	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
999541013657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541013658	active site
999541013659	phosphorylation site [posttranslational modification]
999541013660	intermolecular recognition site; other site
999541013661	dimerization interface [polypeptide binding]; other site
999541013662	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541013663	DNA binding site [nucleotide binding]
999541013664	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
999541013665	PAS domain; Region: PAS; smart00091
999541013666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541013667	dimer interface [polypeptide binding]; other site
999541013668	phosphorylation site [posttranslational modification]
999541013669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541013670	ATP binding site [chemical binding]; other site
999541013671	Mg2+ binding site [ion binding]; other site
999541013672	G-X-G motif; other site
999541013673	polyphosphate kinase; Provisional; Region: PRK05443
999541013674	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
999541013675	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
999541013676	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
999541013677	putative domain interface [polypeptide binding]; other site
999541013678	putative active site [active]
999541013679	catalytic site [active]
999541013680	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
999541013681	putative domain interface [polypeptide binding]; other site
999541013682	putative active site [active]
999541013683	catalytic site [active]
999541013684	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
999541013685	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
999541013686	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
999541013687	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
999541013688	DJ-1 family protein; Region: not_thiJ; TIGR01383
999541013689	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
999541013690	conserved cys residue [active]
999541013691	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541013692	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541013693	conserved cys residue [active]
999541013694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541013695	BON domain; Region: BON; pfam04972
999541013696	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541013697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541013698	Walker A motif; other site
999541013699	ATP binding site [chemical binding]; other site
999541013700	Walker B motif; other site
999541013701	arginine finger; other site
999541013702	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541013703	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541013704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541013705	active site
999541013706	phosphorylation site [posttranslational modification]
999541013707	intermolecular recognition site; other site
999541013708	dimerization interface [polypeptide binding]; other site
999541013709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541013710	Walker A motif; other site
999541013711	ATP binding site [chemical binding]; other site
999541013712	Walker B motif; other site
999541013713	arginine finger; other site
999541013714	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541013715	PAS fold; Region: PAS_4; pfam08448
999541013716	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541013717	putative active site [active]
999541013718	heme pocket [chemical binding]; other site
999541013719	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
999541013720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541013721	putative active site [active]
999541013722	heme pocket [chemical binding]; other site
999541013723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541013724	dimer interface [polypeptide binding]; other site
999541013725	phosphorylation site [posttranslational modification]
999541013726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541013727	ATP binding site [chemical binding]; other site
999541013728	Mg2+ binding site [ion binding]; other site
999541013729	G-X-G motif; other site
999541013730	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
999541013731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541013732	active site
999541013733	phosphorylation site [posttranslational modification]
999541013734	intermolecular recognition site; other site
999541013735	dimerization interface [polypeptide binding]; other site
999541013736	BON domain; Region: BON; pfam04972
999541013737	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
999541013738	PRC-barrel domain; Region: PRC; pfam05239
999541013739	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
999541013740	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
999541013741	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
999541013742	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
999541013743	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
999541013744	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
999541013745	Methyltransferase domain; Region: Methyltransf_18; pfam12847
999541013746	S-adenosylmethionine binding site [chemical binding]; other site
999541013747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541013748	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541013749	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541013750	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541013751	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
999541013752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541013753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541013754	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
999541013755	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
999541013756	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
999541013757	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013758	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013759	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541013760	dimerization interface [polypeptide binding]; other site
999541013761	shikimate transporter; Provisional; Region: PRK09952
999541013762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013763	putative substrate translocation pore; other site
999541013764	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
999541013765	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
999541013766	tetrameric interface [polypeptide binding]; other site
999541013767	NAD binding site [chemical binding]; other site
999541013768	catalytic residues [active]
999541013769	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541013770	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
999541013771	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
999541013772	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
999541013773	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
999541013774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541013775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013776	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541013777	putative effector binding pocket; other site
999541013778	dimerization interface [polypeptide binding]; other site
999541013779	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
999541013780	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
999541013781	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
999541013782	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541013783	putative ligand binding site [chemical binding]; other site
999541013784	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541013785	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541013786	Walker A/P-loop; other site
999541013787	ATP binding site [chemical binding]; other site
999541013788	Q-loop/lid; other site
999541013789	ABC transporter signature motif; other site
999541013790	Walker B; other site
999541013791	D-loop; other site
999541013792	H-loop/switch region; other site
999541013793	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541013794	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541013795	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541013796	TM-ABC transporter signature motif; other site
999541013797	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541013798	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541013799	TM-ABC transporter signature motif; other site
999541013800	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
999541013801	Strictosidine synthase; Region: Str_synth; pfam03088
999541013802	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
999541013803	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541013804	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
999541013805	Walker A/P-loop; other site
999541013806	ATP binding site [chemical binding]; other site
999541013807	Q-loop/lid; other site
999541013808	ABC transporter signature motif; other site
999541013809	Walker B; other site
999541013810	D-loop; other site
999541013811	H-loop/switch region; other site
999541013812	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
999541013813	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
999541013814	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541013815	catalytic core [active]
999541013816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
999541013817	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
999541013818	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
999541013819	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
999541013820	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
999541013821	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
999541013822	active site
999541013823	acyl-activating enzyme (AAE) consensus motif; other site
999541013824	putative CoA binding site [chemical binding]; other site
999541013825	AMP binding site [chemical binding]; other site
999541013826	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541013827	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
999541013828	Peptidase family M23; Region: Peptidase_M23; pfam01551
999541013829	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
999541013830	active site
999541013831	catalytic residues [active]
999541013832	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
999541013833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541013834	putative transposase OrfB; Reviewed; Region: PHA02517
999541013835	Integrase core domain; Region: rve; pfam00665
999541013836	Integrase core domain; Region: rve_3; pfam13683
999541013837	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
999541013838	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541013839	MULE transposase domain; Region: MULE; pfam10551
999541013840	Methyltransferase domain; Region: Methyltransf_11; pfam08241
999541013841	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541013842	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
999541013843	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
999541013844	Methyltransferase domain; Region: Methyltransf_26; pfam13659
999541013845	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
999541013846	TIGR02687 family protein; Region: TIGR02687
999541013847	PglZ domain; Region: PglZ; pfam08665
999541013848	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
999541013849	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
999541013850	HNH endonuclease; Region: HNH_2; pfam13391
999541013851	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
999541013852	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
999541013853	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541013854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541013855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
999541013856	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
999541013857	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541013858	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541013859	non-specific DNA binding site [nucleotide binding]; other site
999541013860	salt bridge; other site
999541013861	sequence-specific DNA binding site [nucleotide binding]; other site
999541013862	Methyltransferase domain; Region: Methyltransf_27; pfam13708
999541013863	short chain dehydrogenase; Provisional; Region: PRK07326
999541013864	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
999541013865	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
999541013866	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
999541013867	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
999541013868	G1 box; other site
999541013869	GTP/Mg2+ binding site [chemical binding]; other site
999541013870	G2 box; other site
999541013871	Switch I region; other site
999541013872	G3 box; other site
999541013873	Switch II region; other site
999541013874	G4 box; other site
999541013875	G5 box; other site
999541013876	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
999541013877	Dynamin family; Region: Dynamin_N; pfam00350
999541013878	G1 box; other site
999541013879	GTP/Mg2+ binding site [chemical binding]; other site
999541013880	G2 box; other site
999541013881	Switch I region; other site
999541013882	G3 box; other site
999541013883	Switch II region; other site
999541013884	G4 box; other site
999541013885	G5 box; other site
999541013886	Domain of unknown function DUF87; Region: DUF87; pfam01935
999541013887	AAA-like domain; Region: AAA_10; pfam12846
999541013888	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
999541013889	Predicted transcriptional regulator [Transcription]; Region: COG2378
999541013890	WYL domain; Region: WYL; pfam13280
999541013891	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541013892	putative active site [active]
999541013893	catalytic site [active]
999541013894	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541013895	nucleotide binding region [chemical binding]; other site
999541013896	ATP-binding site [chemical binding]; other site
999541013897	Src Homology 3 domain superfamily; Region: SH3; cl17036
999541013898	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
999541013899	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
999541013900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541013901	non-specific DNA binding site [nucleotide binding]; other site
999541013902	salt bridge; other site
999541013903	sequence-specific DNA binding site [nucleotide binding]; other site
999541013904	Domain of unknown function (DUF955); Region: DUF955; cl01076
999541013905	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
999541013906	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541013907	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541013908	NAD(P) binding site [chemical binding]; other site
999541013909	catalytic residues [active]
999541013910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541013911	NAD(P) binding site [chemical binding]; other site
999541013912	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
999541013913	active site
999541013914	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
999541013915	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
999541013916	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
999541013917	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541013918	inhibitor-cofactor binding pocket; inhibition site
999541013919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541013920	catalytic residue [active]
999541013921	phosphoribosylamine--glycine ligase; Region: PLN02257
999541013922	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541013923	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
999541013924	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
999541013925	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541013926	PYR/PP interface [polypeptide binding]; other site
999541013927	dimer interface [polypeptide binding]; other site
999541013928	TPP binding site [chemical binding]; other site
999541013929	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541013930	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
999541013931	TPP-binding site [chemical binding]; other site
999541013932	dimer interface [polypeptide binding]; other site
999541013933	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541013934	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541013935	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
999541013936	N-terminal domain interface [polypeptide binding]; other site
999541013937	dimer interface [polypeptide binding]; other site
999541013938	substrate binding pocket (H-site) [chemical binding]; other site
999541013939	TIGR02646 family protein; Region: TIGR02646
999541013940	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
999541013941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541013942	Walker A/P-loop; other site
999541013943	ATP binding site [chemical binding]; other site
999541013944	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
999541013945	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541013946	active site
999541013947	DNA binding site [nucleotide binding]
999541013948	Int/Topo IB signature motif; other site
999541013949	putative transposase OrfB; Reviewed; Region: PHA02517
999541013950	Integrase core domain; Region: rve; pfam00665
999541013951	Integrase core domain; Region: rve_3; pfam13683
999541013952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541013953	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541013954	MULE transposase domain; Region: MULE; pfam10551
999541013955	Predicted acyl esterases [General function prediction only]; Region: COG2936
999541013956	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
999541013957	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
999541013958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013959	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
999541013960	putative substrate translocation pore; other site
999541013961	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
999541013962	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541013963	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541013964	dimerization interface [polypeptide binding]; other site
999541013965	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
999541013966	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
999541013967	dimer interface [polypeptide binding]; other site
999541013968	active site
999541013969	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
999541013970	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
999541013971	active site
999541013972	citrylCoA binding site [chemical binding]; other site
999541013973	oxalacetate binding site [chemical binding]; other site
999541013974	coenzyme A binding site [chemical binding]; other site
999541013975	catalytic triad [active]
999541013976	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541013977	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
999541013978	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541013979	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541013980	putative transposase OrfB; Reviewed; Region: PHA02517
999541013981	Integrase core domain; Region: rve; pfam00665
999541013982	Integrase core domain; Region: rve_3; pfam13683
999541013983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541013984	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
999541013985	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541013986	MarR family; Region: MarR_2; pfam12802
999541013987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541013988	D-galactonate transporter; Region: 2A0114; TIGR00893
999541013989	putative substrate translocation pore; other site
999541013990	hypothetical protein; Validated; Region: PRK07586
999541013991	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541013992	PYR/PP interface [polypeptide binding]; other site
999541013993	dimer interface [polypeptide binding]; other site
999541013994	TPP binding site [chemical binding]; other site
999541013995	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
999541013996	TPP-binding site [chemical binding]; other site
999541013997	dimer interface [polypeptide binding]; other site
999541013998	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
999541013999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541014000	NAD(P) binding site [chemical binding]; other site
999541014001	active site
999541014002	BNR repeat-like domain; Region: BNR_2; pfam13088
999541014003	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
999541014004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541014005	putative active site [active]
999541014006	putative metal binding site [ion binding]; other site
999541014007	Amino acid synthesis; Region: AA_synth; pfam06684
999541014008	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541014009	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541014010	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
999541014011	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541014012	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541014013	NIPSNAP; Region: NIPSNAP; pfam07978
999541014014	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541014015	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541014016	tetramerization interface [polypeptide binding]; other site
999541014017	NAD(P) binding site [chemical binding]; other site
999541014018	catalytic residues [active]
999541014019	succinic semialdehyde dehydrogenase; Region: PLN02278
999541014020	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541014021	tetramerization interface [polypeptide binding]; other site
999541014022	NAD(P) binding site [chemical binding]; other site
999541014023	catalytic residues [active]
999541014024	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541014025	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541014026	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541014027	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
999541014028	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541014029	NAD(P) binding site [chemical binding]; other site
999541014030	catalytic residues [active]
999541014031	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
999541014032	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541014033	Flavin Reductases; Region: FlaRed; cl00801
999541014034	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
999541014035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541014036	active site
999541014037	phosphorylation site [posttranslational modification]
999541014038	intermolecular recognition site; other site
999541014039	dimerization interface [polypeptide binding]; other site
999541014040	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541014041	DNA binding residues [nucleotide binding]
999541014042	dimerization interface [polypeptide binding]; other site
999541014043	metabolite-proton symporter; Region: 2A0106; TIGR00883
999541014044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014045	putative substrate translocation pore; other site
999541014046	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541014047	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541014048	trimer interface [polypeptide binding]; other site
999541014049	eyelet of channel; other site
999541014050	classical (c) SDRs; Region: SDR_c; cd05233
999541014051	NAD(P) binding site [chemical binding]; other site
999541014052	active site
999541014053	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541014054	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541014055	active site
999541014056	PAS domain; Region: PAS_9; pfam13426
999541014057	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
999541014058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541014059	putative active site [active]
999541014060	heme pocket [chemical binding]; other site
999541014061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541014062	dimer interface [polypeptide binding]; other site
999541014063	phosphorylation site [posttranslational modification]
999541014064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541014065	ATP binding site [chemical binding]; other site
999541014066	Mg2+ binding site [ion binding]; other site
999541014067	G-X-G motif; other site
999541014068	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541014069	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541014070	trimer interface [polypeptide binding]; other site
999541014071	eyelet of channel; other site
999541014072	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
999541014073	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
999541014074	Amidase; Region: Amidase; cl11426
999541014075	SnoaL-like domain; Region: SnoaL_4; pfam13577
999541014076	Tautomerase enzyme; Region: Tautomerase; pfam01361
999541014077	active site 1 [active]
999541014078	dimer interface [polypeptide binding]; other site
999541014079	hexamer interface [polypeptide binding]; other site
999541014080	active site 2 [active]
999541014081	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
999541014082	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
999541014083	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
999541014084	[2Fe-2S] cluster binding site [ion binding]; other site
999541014085	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
999541014086	putative alpha subunit interface [polypeptide binding]; other site
999541014087	putative active site [active]
999541014088	putative substrate binding site [chemical binding]; other site
999541014089	Fe binding site [ion binding]; other site
999541014090	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
999541014091	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
999541014092	FMN-binding pocket [chemical binding]; other site
999541014093	flavin binding motif; other site
999541014094	phosphate binding motif [ion binding]; other site
999541014095	beta-alpha-beta structure motif; other site
999541014096	NAD binding pocket [chemical binding]; other site
999541014097	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541014098	catalytic loop [active]
999541014099	iron binding site [ion binding]; other site
999541014100	ornithine cyclodeaminase; Validated; Region: PRK06199
999541014101	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
999541014102	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
999541014103	homotrimer interaction site [polypeptide binding]; other site
999541014104	putative active site [active]
999541014105	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541014106	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541014107	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
999541014108	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541014109	Integrase core domain; Region: rve; pfam00665
999541014110	DDE domain; Region: DDE_Tnp_IS240; pfam13610
999541014111	putative transposase OrfB; Reviewed; Region: PHA02517
999541014112	Integrase core domain; Region: rve; pfam00665
999541014113	Integrase core domain; Region: rve_3; pfam13683
999541014114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541014115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541014116	HTH-like domain; Region: HTH_21; pfam13276
999541014117	Integrase core domain; Region: rve; pfam00665
999541014118	Integrase core domain; Region: rve_3; pfam13683
999541014119	Transposase; Region: HTH_Tnp_1; pfam01527
999541014120	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
999541014121	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
999541014122	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541014123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541014124	S-adenosylmethionine binding site [chemical binding]; other site
999541014125	hypothetical protein; Provisional; Region: PRK06126
999541014126	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
999541014127	DDE domain; Region: DDE_Tnp_IS240; pfam13610
999541014128	Integrase core domain; Region: rve; pfam00665
999541014129	H-NS histone family; Region: Histone_HNS; pfam00816
999541014130	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541014131	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
999541014132	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
999541014133	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
999541014134	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
999541014135	Substrate binding site; other site
999541014136	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
999541014137	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541014138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541014139	Walker A motif; other site
999541014140	ATP binding site [chemical binding]; other site
999541014141	Walker B motif; other site
999541014142	arginine finger; other site
999541014143	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541014144	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
999541014145	active site
999541014146	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
999541014147	Acyltransferase family; Region: Acyl_transf_3; pfam01757
999541014148	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541014149	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541014150	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541014151	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541014152	acyl carrier protein; Provisional; Region: PRK07081
999541014153	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
999541014154	dimer interface [polypeptide binding]; other site
999541014155	motif 1; other site
999541014156	active site
999541014157	motif 2; other site
999541014158	motif 3; other site
999541014159	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541014160	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
999541014161	putative ADP-binding pocket [chemical binding]; other site
999541014162	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541014163	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541014164	ligand binding site [chemical binding]; other site
999541014165	flexible hinge region; other site
999541014166	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541014167	non-specific DNA interactions [nucleotide binding]; other site
999541014168	DNA binding site [nucleotide binding]
999541014169	sequence specific DNA binding site [nucleotide binding]; other site
999541014170	putative cAMP binding site [chemical binding]; other site
999541014171	polysaccharide export protein Wza; Provisional; Region: PRK15078
999541014172	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541014173	SLBB domain; Region: SLBB; pfam10531
999541014174	Chain length determinant protein; Region: Wzz; cl15801
999541014175	tyrosine kinase; Provisional; Region: PRK11519
999541014176	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
999541014177	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
999541014178	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541014179	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
999541014180	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
999541014181	NAD binding site [chemical binding]; other site
999541014182	substrate binding site [chemical binding]; other site
999541014183	homodimer interface [polypeptide binding]; other site
999541014184	active site
999541014185	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
999541014186	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
999541014187	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
999541014188	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541014189	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
999541014190	active site
999541014191	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
999541014192	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
999541014193	trimer interface [polypeptide binding]; other site
999541014194	active site
999541014195	substrate binding site [chemical binding]; other site
999541014196	CoA binding site [chemical binding]; other site
999541014197	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541014198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541014199	NAD(P) binding site [chemical binding]; other site
999541014200	active site
999541014201	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541014202	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
999541014203	Probable Catalytic site; other site
999541014204	metal-binding site
999541014205	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
999541014206	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
999541014207	substrate binding site; other site
999541014208	tetramer interface; other site
999541014209	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
999541014210	Bacterial sugar transferase; Region: Bac_transf; pfam02397
999541014211	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
999541014212	active site
999541014213	tetramer interface; other site
999541014214	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541014215	HTH-like domain; Region: HTH_21; pfam13276
999541014216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541014217	Integrase core domain; Region: rve; pfam00665
999541014218	Integrase core domain; Region: rve_2; pfam13333
999541014219	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541014220	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541014221	eyelet of channel; other site
999541014222	trimer interface [polypeptide binding]; other site
999541014223	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
999541014224	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
999541014225	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014227	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541014228	dimerization interface [polypeptide binding]; other site
999541014229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014231	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541014232	dimerization interface [polypeptide binding]; other site
999541014233	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541014234	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
999541014235	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
999541014236	NAD(P) binding site [chemical binding]; other site
999541014237	catalytic residues [active]
999541014238	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541014239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541014240	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541014241	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541014242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541014243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541014244	ATP binding site [chemical binding]; other site
999541014245	Mg2+ binding site [ion binding]; other site
999541014246	G-X-G motif; other site
999541014247	Response regulator receiver domain; Region: Response_reg; pfam00072
999541014248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541014249	active site
999541014250	phosphorylation site [posttranslational modification]
999541014251	intermolecular recognition site; other site
999541014252	dimerization interface [polypeptide binding]; other site
999541014253	BetR domain; Region: BetR; pfam08667
999541014254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
999541014255	active site
999541014256	phosphorylation site [posttranslational modification]
999541014257	intermolecular recognition site; other site
999541014258	dimerization interface [polypeptide binding]; other site
999541014259	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
999541014260	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014261	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014262	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541014263	putative effector binding pocket; other site
999541014264	dimerization interface [polypeptide binding]; other site
999541014265	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
999541014266	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
999541014267	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541014268	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
999541014269	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
999541014270	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
999541014271	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
999541014272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014273	putative substrate translocation pore; other site
999541014274	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
999541014275	short chain dehydrogenase; Provisional; Region: PRK07326
999541014276	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
999541014277	putative NAD(P) binding site [chemical binding]; other site
999541014278	active site
999541014279	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541014280	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541014281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541014282	dimer interface [polypeptide binding]; other site
999541014283	conserved gate region; other site
999541014284	putative PBP binding loops; other site
999541014285	ABC-ATPase subunit interface; other site
999541014286	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541014287	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541014288	substrate binding pocket [chemical binding]; other site
999541014289	membrane-bound complex binding site; other site
999541014290	hinge residues; other site
999541014291	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541014292	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541014293	Walker A/P-loop; other site
999541014294	ATP binding site [chemical binding]; other site
999541014295	Q-loop/lid; other site
999541014296	ABC transporter signature motif; other site
999541014297	Walker B; other site
999541014298	D-loop; other site
999541014299	H-loop/switch region; other site
999541014300	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541014301	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541014302	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
999541014303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541014305	dimerization interface [polypeptide binding]; other site
999541014306	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541014307	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541014308	dimer interface [polypeptide binding]; other site
999541014309	putative CheW interface [polypeptide binding]; other site
999541014310	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541014311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541014312	DNA-binding site [nucleotide binding]; DNA binding site
999541014313	FCD domain; Region: FCD; pfam07729
999541014314	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541014315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014316	putative substrate translocation pore; other site
999541014317	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
999541014318	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
999541014319	active site
999541014320	tetramer interface [polypeptide binding]; other site
999541014321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014322	D-galactonate transporter; Region: 2A0114; TIGR00893
999541014323	putative substrate translocation pore; other site
999541014324	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
999541014325	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541014326	catalytic residues [active]
999541014327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541014328	Coenzyme A binding pocket [chemical binding]; other site
999541014329	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541014330	DNA-binding site [nucleotide binding]; DNA binding site
999541014331	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
999541014332	FCD domain; Region: FCD; pfam07729
999541014333	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
999541014334	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541014335	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541014336	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541014337	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
999541014338	DNA binding residues [nucleotide binding]
999541014339	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
999541014340	Predicted membrane protein [Function unknown]; Region: COG2259
999541014341	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
999541014342	hypothetical protein; Provisional; Region: PRK05409
999541014343	Predicted integral membrane protein [Function unknown]; Region: COG5572
999541014344	Predicted integral membrane protein [Function unknown]; Region: COG5572
999541014345	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
999541014346	MbtH-like protein; Region: MbtH; cl01279
999541014347	Cupin-like domain; Region: Cupin_8; pfam13621
999541014348	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
999541014349	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541014350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541014351	homodimer interface [polypeptide binding]; other site
999541014352	catalytic residue [active]
999541014353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541014354	S-adenosylmethionine binding site [chemical binding]; other site
999541014355	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
999541014356	active site
999541014357	substrate binding site [chemical binding]; other site
999541014358	cosubstrate binding site; other site
999541014359	catalytic site [active]
999541014360	argininosuccinate synthase; Provisional; Region: PRK13820
999541014361	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
999541014362	ANP binding site [chemical binding]; other site
999541014363	Substrate Binding Site II [chemical binding]; other site
999541014364	Substrate Binding Site I [chemical binding]; other site
999541014365	argininosuccinate lyase; Provisional; Region: PRK00855
999541014366	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
999541014367	active sites [active]
999541014368	tetramer interface [polypeptide binding]; other site
999541014369	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
999541014370	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
999541014371	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541014372	catalytic residue [active]
999541014373	argininosuccinate lyase; Provisional; Region: PRK02186
999541014374	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
999541014375	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
999541014376	tetramer interface [polypeptide binding]; other site
999541014377	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
999541014378	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
999541014379	tetramer interface [polypeptide binding]; other site
999541014380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541014381	catalytic residue [active]
999541014382	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
999541014383	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
999541014384	acyl-CoA synthetase; Validated; Region: PRK05850
999541014385	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541014386	acyl-activating enzyme (AAE) consensus motif; other site
999541014387	active site
999541014388	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541014389	Condensation domain; Region: Condensation; pfam00668
999541014390	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541014391	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541014392	acyl-activating enzyme (AAE) consensus motif; other site
999541014393	AMP binding site [chemical binding]; other site
999541014394	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541014395	Condensation domain; Region: Condensation; pfam00668
999541014396	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541014397	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541014398	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541014399	acyl-activating enzyme (AAE) consensus motif; other site
999541014400	AMP binding site [chemical binding]; other site
999541014401	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541014402	Condensation domain; Region: Condensation; pfam00668
999541014403	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541014404	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541014405	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541014406	acyl-activating enzyme (AAE) consensus motif; other site
999541014407	AMP binding site [chemical binding]; other site
999541014408	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541014409	Condensation domain; Region: Condensation; pfam00668
999541014410	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541014411	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541014412	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541014413	acyl-activating enzyme (AAE) consensus motif; other site
999541014414	AMP binding site [chemical binding]; other site
999541014415	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541014416	Condensation domain; Region: Condensation; pfam00668
999541014417	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541014418	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541014419	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541014420	acyl-activating enzyme (AAE) consensus motif; other site
999541014421	AMP binding site [chemical binding]; other site
999541014422	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541014423	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541014424	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
999541014425	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
999541014426	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
999541014427	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
999541014428	active site
999541014429	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
999541014430	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
999541014431	gating phenylalanine in ion channel; other site
999541014432	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014433	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014434	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
999541014435	putative dimerization interface [polypeptide binding]; other site
999541014436	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541014437	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541014438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541014439	active site
999541014440	phosphorylation site [posttranslational modification]
999541014441	intermolecular recognition site; other site
999541014442	dimerization interface [polypeptide binding]; other site
999541014443	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541014444	DNA binding site [nucleotide binding]
999541014445	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
999541014446	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
999541014447	phosphate binding site [ion binding]; other site
999541014448	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
999541014449	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541014450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541014451	homodimer interface [polypeptide binding]; other site
999541014452	catalytic residue [active]
999541014453	Glutamine amidotransferase class-I; Region: GATase; pfam00117
999541014454	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
999541014455	glutamine binding [chemical binding]; other site
999541014456	catalytic triad [active]
999541014457	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
999541014458	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
999541014459	tetramer interface [polypeptide binding]; other site
999541014460	heme binding pocket [chemical binding]; other site
999541014461	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
999541014462	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
999541014463	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
999541014464	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
999541014465	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541014466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014467	putative substrate translocation pore; other site
999541014468	Cupin; Region: Cupin_6; pfam12852
999541014469	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541014470	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541014471	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541014472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014473	D-galactonate transporter; Region: 2A0114; TIGR00893
999541014474	putative substrate translocation pore; other site
999541014475	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014477	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
999541014478	putative dimerization interface [polypeptide binding]; other site
999541014479	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541014480	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
999541014481	active site pocket [active]
999541014482	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
999541014483	galactarate dehydratase; Region: galactar-dH20; TIGR03248
999541014484	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
999541014485	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541014486	extended (e) SDRs; Region: SDR_e; cd08946
999541014487	NAD(P) binding site [chemical binding]; other site
999541014488	active site
999541014489	substrate binding site [chemical binding]; other site
999541014490	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
999541014491	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
999541014492	putative NAD(P) binding site [chemical binding]; other site
999541014493	putative active site [active]
999541014494	hypothetical protein; Validated; Region: PRK08245
999541014495	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
999541014496	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541014497	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541014498	active site
999541014499	catalytic tetrad [active]
999541014500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541014501	S-adenosylmethionine binding site [chemical binding]; other site
999541014502	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
999541014503	Ligand binding site [chemical binding]; other site
999541014504	Electron transfer flavoprotein domain; Region: ETF; pfam01012
999541014505	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
999541014506	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
999541014507	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
999541014508	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
999541014509	benzoate transport; Region: 2A0115; TIGR00895
999541014510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014511	putative substrate translocation pore; other site
999541014512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014513	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541014514	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541014515	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541014516	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541014517	active site
999541014518	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
999541014519	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
999541014520	active site 2 [active]
999541014521	active site 1 [active]
999541014522	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
999541014523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014524	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
999541014525	putative dimerization interface [polypeptide binding]; other site
999541014526	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541014527	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541014528	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541014529	putative active site [active]
999541014530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541014531	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541014532	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541014533	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541014534	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541014535	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541014536	RHS Repeat; Region: RHS_repeat; cl11982
999541014537	RHS Repeat; Region: RHS_repeat; pfam05593
999541014538	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541014539	RHS Repeat; Region: RHS_repeat; pfam05593
999541014540	RHS Repeat; Region: RHS_repeat; pfam05593
999541014541	RHS Repeat; Region: RHS_repeat; pfam05593
999541014542	RHS Repeat; Region: RHS_repeat; pfam05593
999541014543	RHS Repeat; Region: RHS_repeat; pfam05593
999541014544	RHS Repeat; Region: RHS_repeat; cl11982
999541014545	RHS Repeat; Region: RHS_repeat; pfam05593
999541014546	RHS protein; Region: RHS; pfam03527
999541014547	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541014548	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541014549	RHS Repeat; Region: RHS_repeat; pfam05593
999541014550	RHS protein; Region: RHS; pfam03527
999541014551	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541014552	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
999541014553	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
999541014554	SnoaL-like domain; Region: SnoaL_2; pfam12680
999541014555	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541014556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014557	putative substrate translocation pore; other site
999541014558	NMT1-like family; Region: NMT1_2; pfam13379
999541014559	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541014560	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541014561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541014562	active site
999541014563	phosphorylation site [posttranslational modification]
999541014564	intermolecular recognition site; other site
999541014565	dimerization interface [polypeptide binding]; other site
999541014566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541014567	DNA binding site [nucleotide binding]
999541014568	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
999541014569	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
999541014570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541014571	dimer interface [polypeptide binding]; other site
999541014572	phosphorylation site [posttranslational modification]
999541014573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541014574	ATP binding site [chemical binding]; other site
999541014575	Mg2+ binding site [ion binding]; other site
999541014576	G-X-G motif; other site
999541014577	Predicted ester cyclase [General function prediction only]; Region: COG5485
999541014578	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
999541014579	active site
999541014580	dimer interface [polypeptide binding]; other site
999541014581	motif 2; other site
999541014582	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
999541014583	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
999541014584	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
999541014585	NUDIX domain; Region: NUDIX; pfam00293
999541014586	nudix motif; other site
999541014587	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
999541014588	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541014589	active site
999541014590	HIGH motif; other site
999541014591	nucleotide binding site [chemical binding]; other site
999541014592	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
999541014593	KMSKS motif; other site
999541014594	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
999541014595	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541014596	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541014597	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
999541014598	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
999541014599	motif 1; other site
999541014600	active site
999541014601	motif 2; other site
999541014602	motif 3; other site
999541014603	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
999541014604	DHHA1 domain; Region: DHHA1; pfam02272
999541014605	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014607	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541014608	putative effector binding pocket; other site
999541014609	putative dimerization interface [polypeptide binding]; other site
999541014610	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
999541014611	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541014612	NAD binding site [chemical binding]; other site
999541014613	catalytic residues [active]
999541014614	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
999541014615	active site
999541014616	catalytic residues [active]
999541014617	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541014618	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541014619	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541014620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541014621	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
999541014622	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
999541014623	putative ligand binding site [chemical binding]; other site
999541014624	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
999541014625	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541014626	Walker A/P-loop; other site
999541014627	ATP binding site [chemical binding]; other site
999541014628	Q-loop/lid; other site
999541014629	ABC transporter signature motif; other site
999541014630	Walker B; other site
999541014631	D-loop; other site
999541014632	H-loop/switch region; other site
999541014633	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541014634	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541014635	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541014636	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541014637	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541014638	TM-ABC transporter signature motif; other site
999541014639	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
999541014640	classical (c) SDRs; Region: SDR_c; cd05233
999541014641	NAD(P) binding site [chemical binding]; other site
999541014642	active site
999541014643	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541014644	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014645	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541014646	dimerization interface [polypeptide binding]; other site
999541014647	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
999541014648	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
999541014649	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
999541014650	nudix motif; other site
999541014651	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
999541014652	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
999541014653	active site
999541014654	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
999541014655	TM-ABC transporter signature motif; other site
999541014656	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541014657	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541014658	TM-ABC transporter signature motif; other site
999541014659	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541014660	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541014661	Walker A/P-loop; other site
999541014662	ATP binding site [chemical binding]; other site
999541014663	Q-loop/lid; other site
999541014664	ABC transporter signature motif; other site
999541014665	Walker B; other site
999541014666	D-loop; other site
999541014667	H-loop/switch region; other site
999541014668	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541014669	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541014670	Walker A/P-loop; other site
999541014671	ATP binding site [chemical binding]; other site
999541014672	Q-loop/lid; other site
999541014673	ABC transporter signature motif; other site
999541014674	Walker B; other site
999541014675	D-loop; other site
999541014676	H-loop/switch region; other site
999541014677	KduI/IolB family; Region: KduI; pfam04962
999541014678	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
999541014679	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
999541014680	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541014681	PYR/PP interface [polypeptide binding]; other site
999541014682	dimer interface [polypeptide binding]; other site
999541014683	TPP binding site [chemical binding]; other site
999541014684	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541014685	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
999541014686	TPP-binding site [chemical binding]; other site
999541014687	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541014688	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
999541014689	substrate binding site [chemical binding]; other site
999541014690	ATP binding site [chemical binding]; other site
999541014691	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
999541014692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
999541014693	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541014694	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541014695	Walker A/P-loop; other site
999541014696	ATP binding site [chemical binding]; other site
999541014697	Q-loop/lid; other site
999541014698	ABC transporter signature motif; other site
999541014699	Walker B; other site
999541014700	D-loop; other site
999541014701	H-loop/switch region; other site
999541014702	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541014703	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541014704	TM-ABC transporter signature motif; other site
999541014705	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
999541014706	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541014707	putative ligand binding site [chemical binding]; other site
999541014708	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541014709	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541014710	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541014711	putative active site [active]
999541014712	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
999541014713	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541014714	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
999541014715	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
999541014716	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541014717	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
999541014718	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
999541014719	CPxP  motif; other site
999541014720	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541014721	dimerization interface [polypeptide binding]; other site
999541014722	putative DNA binding site [nucleotide binding]; other site
999541014723	putative Zn2+ binding site [ion binding]; other site
999541014724	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
999541014725	putative hydrophobic ligand binding site [chemical binding]; other site
999541014726	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541014727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541014728	active site
999541014729	phosphorylation site [posttranslational modification]
999541014730	intermolecular recognition site; other site
999541014731	dimerization interface [polypeptide binding]; other site
999541014732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541014733	DNA binding site [nucleotide binding]
999541014734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
999541014735	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541014736	FecR protein; Region: FecR; pfam04773
999541014737	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
999541014738	CHASE2 domain; Region: CHASE2; pfam05226
999541014739	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
999541014740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541014741	dimer interface [polypeptide binding]; other site
999541014742	phosphorylation site [posttranslational modification]
999541014743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541014744	ATP binding site [chemical binding]; other site
999541014745	Mg2+ binding site [ion binding]; other site
999541014746	G-X-G motif; other site
999541014747	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
999541014748	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
999541014749	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
999541014750	active site
999541014751	tetramer interface; other site
999541014752	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
999541014753	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541014754	active site
999541014755	HIGH motif; other site
999541014756	nucleotide binding site [chemical binding]; other site
999541014757	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
999541014758	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
999541014759	active site
999541014760	KMSKS motif; other site
999541014761	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
999541014762	tRNA binding surface [nucleotide binding]; other site
999541014763	anticodon binding site; other site
999541014764	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
999541014765	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
999541014766	Part of AAA domain; Region: AAA_19; pfam13245
999541014767	Family description; Region: UvrD_C_2; pfam13538
999541014768	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
999541014769	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
999541014770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014771	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541014772	putative substrate translocation pore; other site
999541014773	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541014774	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541014775	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541014776	dimer interface [polypeptide binding]; other site
999541014777	putative CheW interface [polypeptide binding]; other site
999541014778	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
999541014779	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541014780	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541014781	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
999541014782	Fusaric acid resistance protein family; Region: FUSC; pfam04632
999541014783	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
999541014784	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541014785	transcriptional regulator; Provisional; Region: PRK10632
999541014786	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014787	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541014788	putative effector binding pocket; other site
999541014789	dimerization interface [polypeptide binding]; other site
999541014790	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
999541014791	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
999541014792	putative active site [active]
999541014793	putative metal binding site [ion binding]; other site
999541014794	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541014795	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541014796	FAD binding domain; Region: FAD_binding_4; pfam01565
999541014797	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541014798	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541014799	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
999541014800	Protein of unknown function (DUF962); Region: DUF962; cl01879
999541014801	FOG: CBS domain [General function prediction only]; Region: COG0517
999541014802	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541014803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014804	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
999541014805	putative acyl-acceptor binding pocket; other site
999541014806	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
999541014807	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
999541014808	Tetramer interface [polypeptide binding]; other site
999541014809	active site
999541014810	FMN-binding site [chemical binding]; other site
999541014811	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
999541014812	hydroxyglutarate oxidase; Provisional; Region: PRK11728
999541014813	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
999541014814	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
999541014815	short chain dehydrogenase; Provisional; Region: PRK06949
999541014816	classical (c) SDRs; Region: SDR_c; cd05233
999541014817	NAD(P) binding site [chemical binding]; other site
999541014818	active site
999541014819	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
999541014820	active site
999541014821	PAS domain; Region: PAS_9; pfam13426
999541014822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541014823	putative active site [active]
999541014824	heme pocket [chemical binding]; other site
999541014825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541014826	DNA binding residues [nucleotide binding]
999541014827	dimerization interface [polypeptide binding]; other site
999541014828	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
999541014829	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
999541014830	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541014831	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541014832	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
999541014833	homotrimer interaction site [polypeptide binding]; other site
999541014834	putative active site [active]
999541014835	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
999541014836	HD domain; Region: HD_4; pfam13328
999541014837	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
999541014838	synthetase active site [active]
999541014839	NTP binding site [chemical binding]; other site
999541014840	metal binding site [ion binding]; metal-binding site
999541014841	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
999541014842	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
999541014843	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
999541014844	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
999541014845	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
999541014846	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
999541014847	active site
999541014848	dimer interface [polypeptide binding]; other site
999541014849	motif 1; other site
999541014850	motif 2; other site
999541014851	motif 3; other site
999541014852	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
999541014853	anticodon binding site; other site
999541014854	translation initiation factor IF-3; Region: infC; TIGR00168
999541014855	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
999541014856	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
999541014857	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
999541014858	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
999541014859	23S rRNA binding site [nucleotide binding]; other site
999541014860	L21 binding site [polypeptide binding]; other site
999541014861	L13 binding site [polypeptide binding]; other site
999541014862	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
999541014863	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
999541014864	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
999541014865	dimer interface [polypeptide binding]; other site
999541014866	motif 1; other site
999541014867	active site
999541014868	motif 2; other site
999541014869	motif 3; other site
999541014870	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
999541014871	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
999541014872	putative tRNA-binding site [nucleotide binding]; other site
999541014873	B3/4 domain; Region: B3_4; pfam03483
999541014874	tRNA synthetase B5 domain; Region: B5; smart00874
999541014875	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
999541014876	dimer interface [polypeptide binding]; other site
999541014877	motif 1; other site
999541014878	motif 3; other site
999541014879	motif 2; other site
999541014880	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
999541014881	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
999541014882	IHF dimer interface [polypeptide binding]; other site
999541014883	IHF - DNA interface [nucleotide binding]; other site
999541014884	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
999541014885	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
999541014886	DNA binding residues [nucleotide binding]
999541014887	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
999541014888	Flp/Fap pilin component; Region: Flp_Fap; cl01585
999541014889	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541014890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541014891	DNA-binding site [nucleotide binding]; DNA binding site
999541014892	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541014893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541014894	homodimer interface [polypeptide binding]; other site
999541014895	catalytic residue [active]
999541014896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014897	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541014898	putative substrate translocation pore; other site
999541014899	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
999541014900	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
999541014901	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
999541014902	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
999541014903	Uncharacterized conserved protein [Function unknown]; Region: COG1434
999541014904	putative active site [active]
999541014905	bifunctional mannosyl-3-phosphoglycerate synthase/mannosyl-3 phosphoglycerate phosphatase; Provisional; Region: PRK14502
999541014906	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
999541014907	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
999541014908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541014909	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
999541014910	putative dimerization interface [polypeptide binding]; other site
999541014911	aspartate aminotransferase; Provisional; Region: PRK06108
999541014912	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541014913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541014914	homodimer interface [polypeptide binding]; other site
999541014915	catalytic residue [active]
999541014916	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
999541014917	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
999541014918	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541014919	RNA binding surface [nucleotide binding]; other site
999541014920	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
999541014921	probable active site [active]
999541014922	ribosome maturation protein RimP; Reviewed; Region: PRK00092
999541014923	Sm and related proteins; Region: Sm_like; cl00259
999541014924	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
999541014925	putative oligomer interface [polypeptide binding]; other site
999541014926	putative RNA binding site [nucleotide binding]; other site
999541014927	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
999541014928	NusA N-terminal domain; Region: NusA_N; pfam08529
999541014929	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
999541014930	RNA binding site [nucleotide binding]; other site
999541014931	homodimer interface [polypeptide binding]; other site
999541014932	NusA-like KH domain; Region: KH_5; pfam13184
999541014933	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
999541014934	G-X-X-G motif; other site
999541014935	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
999541014936	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
999541014937	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
999541014938	translation initiation factor IF-2; Region: IF-2; TIGR00487
999541014939	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
999541014940	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
999541014941	G1 box; other site
999541014942	putative GEF interaction site [polypeptide binding]; other site
999541014943	GTP/Mg2+ binding site [chemical binding]; other site
999541014944	Switch I region; other site
999541014945	G2 box; other site
999541014946	G3 box; other site
999541014947	Switch II region; other site
999541014948	G4 box; other site
999541014949	G5 box; other site
999541014950	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
999541014951	Translation-initiation factor 2; Region: IF-2; pfam11987
999541014952	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
999541014953	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
999541014954	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
999541014955	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
999541014956	RNA binding site [nucleotide binding]; other site
999541014957	active site
999541014958	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
999541014959	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541014960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014961	putative substrate translocation pore; other site
999541014962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541014963	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
999541014964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541014965	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541014966	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541014967	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541014968	MarR family; Region: MarR_2; cl17246
999541014969	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
999541014970	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
999541014971	G1 box; other site
999541014972	putative GEF interaction site [polypeptide binding]; other site
999541014973	GTP/Mg2+ binding site [chemical binding]; other site
999541014974	Switch I region; other site
999541014975	G2 box; other site
999541014976	G3 box; other site
999541014977	Switch II region; other site
999541014978	G4 box; other site
999541014979	G5 box; other site
999541014980	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
999541014981	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
999541014982	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
999541014983	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
999541014984	TPP-binding site [chemical binding]; other site
999541014985	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
999541014986	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
999541014987	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541014988	E3 interaction surface; other site
999541014989	lipoyl attachment site [posttranslational modification]; other site
999541014990	e3 binding domain; Region: E3_binding; pfam02817
999541014991	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
999541014992	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
999541014993	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
999541014994	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541014995	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
999541014996	Predicted ATPase [General function prediction only]; Region: COG1485
999541014997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541014998	Walker B; other site
999541014999	D-loop; other site
999541015000	H-loop/switch region; other site
999541015001	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
999541015002	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
999541015003	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541015004	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541015005	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541015006	Flp/Fap pilin component; Region: Flp_Fap; cl01585
999541015007	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
999541015008	TadE-like protein; Region: TadE; pfam07811
999541015009	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
999541015010	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
999541015011	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
999541015012	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
999541015013	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
999541015014	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541015015	AAA domain; Region: AAA_31; pfam13614
999541015016	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
999541015017	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
999541015018	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
999541015019	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
999541015020	ATP binding site [chemical binding]; other site
999541015021	Walker A motif; other site
999541015022	hexamer interface [polypeptide binding]; other site
999541015023	Walker B motif; other site
999541015024	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
999541015025	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541015026	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
999541015027	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
999541015028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
999541015029	binding surface
999541015030	TPR motif; other site
999541015031	TPR repeat; Region: TPR_11; pfam13414
999541015032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541015033	binding surface
999541015034	TPR motif; other site
999541015035	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
999541015036	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
999541015037	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541015038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541015039	Walker A motif; other site
999541015040	ATP binding site [chemical binding]; other site
999541015041	Walker B motif; other site
999541015042	arginine finger; other site
999541015043	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541015044	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
999541015045	bacterial Hfq-like; Region: Hfq; cd01716
999541015046	hexamer interface [polypeptide binding]; other site
999541015047	Sm1 motif; other site
999541015048	RNA binding site [nucleotide binding]; other site
999541015049	Sm2 motif; other site
999541015050	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
999541015051	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
999541015052	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
999541015053	acyl-activating enzyme (AAE) consensus motif; other site
999541015054	putative AMP binding site [chemical binding]; other site
999541015055	putative active site [active]
999541015056	putative CoA binding site [chemical binding]; other site
999541015057	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541015058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541015059	putative sialic acid transporter; Region: 2A0112; TIGR00891
999541015060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541015061	putative substrate translocation pore; other site
999541015062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541015063	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541015064	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541015065	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
999541015066	high affinity sulphate transporter 1; Region: sulP; TIGR00815
999541015067	Sulfate transporter family; Region: Sulfate_transp; pfam00916
999541015068	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
999541015069	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
999541015070	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
999541015071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015073	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541015074	dimerization interface [polypeptide binding]; other site
999541015075	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541015076	classical (c) SDRs; Region: SDR_c; cd05233
999541015077	NAD(P) binding site [chemical binding]; other site
999541015078	active site
999541015079	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
999541015080	active site 1 [active]
999541015081	dimer interface [polypeptide binding]; other site
999541015082	hexamer interface [polypeptide binding]; other site
999541015083	active site 2 [active]
999541015084	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
999541015085	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
999541015086	FMN binding site [chemical binding]; other site
999541015087	substrate binding site [chemical binding]; other site
999541015088	putative catalytic residue [active]
999541015089	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
999541015090	ribonuclease R; Region: RNase_R; TIGR02063
999541015091	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
999541015092	RNB domain; Region: RNB; pfam00773
999541015093	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
999541015094	RNA binding site [nucleotide binding]; other site
999541015095	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
999541015096	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
999541015097	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
999541015098	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
999541015099	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
999541015100	amidase catalytic site [active]
999541015101	Zn binding residues [ion binding]; other site
999541015102	substrate binding site [chemical binding]; other site
999541015103	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
999541015104	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
999541015105	tetramer (dimer of dimers) interface [polypeptide binding]; other site
999541015106	active site
999541015107	dimer interface [polypeptide binding]; other site
999541015108	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541015109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541015110	DNA-binding site [nucleotide binding]; DNA binding site
999541015111	FCD domain; Region: FCD; pfam07729
999541015112	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
999541015113	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541015114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015115	dimer interface [polypeptide binding]; other site
999541015116	conserved gate region; other site
999541015117	putative PBP binding loops; other site
999541015118	ABC-ATPase subunit interface; other site
999541015119	cystine transporter subunit; Provisional; Region: PRK11260
999541015120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541015121	substrate binding pocket [chemical binding]; other site
999541015122	membrane-bound complex binding site; other site
999541015123	hinge residues; other site
999541015124	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
999541015125	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
999541015126	quinone interaction residues [chemical binding]; other site
999541015127	active site
999541015128	catalytic residues [active]
999541015129	FMN binding site [chemical binding]; other site
999541015130	substrate binding site [chemical binding]; other site
999541015131	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
999541015132	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
999541015133	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
999541015134	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
999541015135	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
999541015136	nudix motif; other site
999541015137	hypothetical protein; Provisional; Region: PRK02487
999541015138	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
999541015139	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
999541015140	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
999541015141	active site
999541015142	dimer interface [polypeptide binding]; other site
999541015143	non-prolyl cis peptide bond; other site
999541015144	insertion regions; other site
999541015145	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541015146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015147	dimer interface [polypeptide binding]; other site
999541015148	conserved gate region; other site
999541015149	putative PBP binding loops; other site
999541015150	ABC-ATPase subunit interface; other site
999541015151	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541015152	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541015153	Walker A/P-loop; other site
999541015154	ATP binding site [chemical binding]; other site
999541015155	Q-loop/lid; other site
999541015156	ABC transporter signature motif; other site
999541015157	Walker B; other site
999541015158	D-loop; other site
999541015159	H-loop/switch region; other site
999541015160	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
999541015161	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
999541015162	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
999541015163	FMN binding site [chemical binding]; other site
999541015164	active site
999541015165	catalytic residues [active]
999541015166	substrate binding site [chemical binding]; other site
999541015167	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541015168	active site
999541015169	DNA binding site [nucleotide binding]
999541015170	Int/Topo IB signature motif; other site
999541015171	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
999541015172	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
999541015173	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
999541015174	Zn binding sites [ion binding]; other site
999541015175	Phage tail tube protein FII; Region: Phage_tube; pfam04985
999541015176	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
999541015177	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
999541015178	Phage Tail Protein X; Region: Phage_tail_X; cl02088
999541015179	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
999541015180	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
999541015181	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
999541015182	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
999541015183	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
999541015184	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
999541015185	Part of AAA domain; Region: AAA_19; pfam13245
999541015186	Family description; Region: UvrD_C_2; pfam13538
999541015187	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541015188	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541015189	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541015190	CoenzymeA binding site [chemical binding]; other site
999541015191	subunit interaction site [polypeptide binding]; other site
999541015192	PHB binding site; other site
999541015193	Predicted metalloprotease [General function prediction only]; Region: COG2321
999541015194	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
999541015195	Predicted permease; Region: DUF318; cl17795
999541015196	ABC-2 type transporter; Region: ABC2_membrane; cl17235
999541015197	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
999541015198	nodulation ABC transporter NodI; Provisional; Region: PRK13537
999541015199	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
999541015200	Walker A/P-loop; other site
999541015201	ATP binding site [chemical binding]; other site
999541015202	Q-loop/lid; other site
999541015203	ABC transporter signature motif; other site
999541015204	Walker B; other site
999541015205	D-loop; other site
999541015206	H-loop/switch region; other site
999541015207	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015208	Ligand Binding Site [chemical binding]; other site
999541015209	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
999541015210	LexA repressor; Validated; Region: PRK00215
999541015211	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
999541015212	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
999541015213	Catalytic site [active]
999541015214	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541015215	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541015216	substrate binding pocket [chemical binding]; other site
999541015217	membrane-bound complex binding site; other site
999541015218	sulfate transport protein; Provisional; Region: cysT; CHL00187
999541015219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015220	dimer interface [polypeptide binding]; other site
999541015221	conserved gate region; other site
999541015222	putative PBP binding loops; other site
999541015223	ABC-ATPase subunit interface; other site
999541015224	sulfate transport protein; Provisional; Region: cysT; CHL00187
999541015225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015226	dimer interface [polypeptide binding]; other site
999541015227	conserved gate region; other site
999541015228	putative PBP binding loops; other site
999541015229	ABC-ATPase subunit interface; other site
999541015230	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
999541015231	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
999541015232	Walker A/P-loop; other site
999541015233	ATP binding site [chemical binding]; other site
999541015234	Q-loop/lid; other site
999541015235	ABC transporter signature motif; other site
999541015236	Walker B; other site
999541015237	D-loop; other site
999541015238	H-loop/switch region; other site
999541015239	TOBE-like domain; Region: TOBE_3; pfam12857
999541015240	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
999541015241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015242	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
999541015243	substrate binding site [chemical binding]; other site
999541015244	dimerization interface [polypeptide binding]; other site
999541015245	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
999541015246	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
999541015247	ligand binding site [chemical binding]; other site
999541015248	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541015249	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541015250	Walker A/P-loop; other site
999541015251	ATP binding site [chemical binding]; other site
999541015252	Q-loop/lid; other site
999541015253	ABC transporter signature motif; other site
999541015254	Walker B; other site
999541015255	D-loop; other site
999541015256	H-loop/switch region; other site
999541015257	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541015258	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541015259	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541015260	TM-ABC transporter signature motif; other site
999541015261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541015262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541015263	DNA binding site [nucleotide binding]
999541015264	domain linker motif; other site
999541015265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541015266	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541015267	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
999541015268	substrate binding site [chemical binding]; other site
999541015269	dimer interface [polypeptide binding]; other site
999541015270	ATP binding site [chemical binding]; other site
999541015271	PrkA family serine protein kinase; Provisional; Region: PRK15455
999541015272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
999541015273	Walker A motif; other site
999541015274	ATP binding site [chemical binding]; other site
999541015275	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
999541015276	hypothetical protein; Provisional; Region: PRK05325
999541015277	SpoVR family protein; Provisional; Region: PRK11767
999541015278	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
999541015279	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
999541015280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541015281	putative substrate translocation pore; other site
999541015282	pteridine reductase; Provisional; Region: PRK09135
999541015283	classical (c) SDRs; Region: SDR_c; cd05233
999541015284	NAD(P) binding site [chemical binding]; other site
999541015285	active site
999541015286	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
999541015287	Peptidase family M23; Region: Peptidase_M23; pfam01551
999541015288	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
999541015289	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
999541015290	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
999541015291	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
999541015292	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
999541015293	catalytic triad [active]
999541015294	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
999541015295	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
999541015296	homodimer interface [polypeptide binding]; other site
999541015297	Walker A motif; other site
999541015298	ATP binding site [chemical binding]; other site
999541015299	hydroxycobalamin binding site [chemical binding]; other site
999541015300	Walker B motif; other site
999541015301	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
999541015302	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
999541015303	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
999541015304	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
999541015305	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
999541015306	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
999541015307	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
999541015308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541015309	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541015310	Walker A motif; other site
999541015311	ATP binding site [chemical binding]; other site
999541015312	Walker B motif; other site
999541015313	arginine finger; other site
999541015314	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
999541015315	metal ion-dependent adhesion site (MIDAS); other site
999541015316	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541015317	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541015318	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541015319	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
999541015320	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541015321	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541015322	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
999541015323	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541015324	catalytic residue [active]
999541015325	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
999541015326	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
999541015327	substrate binding site [chemical binding]; other site
999541015328	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541015329	dimerization interface [polypeptide binding]; other site
999541015330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541015331	dimer interface [polypeptide binding]; other site
999541015332	phosphorylation site [posttranslational modification]
999541015333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541015334	ATP binding site [chemical binding]; other site
999541015335	Mg2+ binding site [ion binding]; other site
999541015336	G-X-G motif; other site
999541015337	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
999541015338	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
999541015339	putative ligand binding residues [chemical binding]; other site
999541015340	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
999541015341	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541015342	ABC-ATPase subunit  interface; other site
999541015343	dimer interface [polypeptide binding]; other site
999541015344	putative PBP binding regions; other site
999541015345	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
999541015346	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541015347	Walker A/P-loop; other site
999541015348	ATP binding site [chemical binding]; other site
999541015349	Q-loop/lid; other site
999541015350	ABC transporter signature motif; other site
999541015351	Walker B; other site
999541015352	D-loop; other site
999541015353	H-loop/switch region; other site
999541015354	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
999541015355	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
999541015356	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
999541015357	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
999541015358	active site
999541015359	SAM binding site [chemical binding]; other site
999541015360	homodimer interface [polypeptide binding]; other site
999541015361	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
999541015362	active site
999541015363	SAM binding site [chemical binding]; other site
999541015364	homodimer interface [polypeptide binding]; other site
999541015365	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
999541015366	Precorrin-8X methylmutase; Region: CbiC; pfam02570
999541015367	precorrin-3B synthase; Region: CobG; TIGR02435
999541015368	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541015369	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
999541015370	active site
999541015371	putative homodimer interface [polypeptide binding]; other site
999541015372	SAM binding site [chemical binding]; other site
999541015373	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
999541015374	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
999541015375	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
999541015376	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
999541015377	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
999541015378	active site
999541015379	SAM binding site [chemical binding]; other site
999541015380	homodimer interface [polypeptide binding]; other site
999541015381	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541015382	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
999541015383	C-terminal domain interface [polypeptide binding]; other site
999541015384	GSH binding site (G-site) [chemical binding]; other site
999541015385	dimer interface [polypeptide binding]; other site
999541015386	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
999541015387	dimer interface [polypeptide binding]; other site
999541015388	N-terminal domain interface [polypeptide binding]; other site
999541015389	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
999541015390	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
999541015391	substrate binding site [chemical binding]; other site
999541015392	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
999541015393	substrate binding site [chemical binding]; other site
999541015394	ligand binding site [chemical binding]; other site
999541015395	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
999541015396	active site
999541015397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541015400	dimerization interface [polypeptide binding]; other site
999541015401	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541015402	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541015403	dimerization interface [polypeptide binding]; other site
999541015404	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541015405	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541015406	dimer interface [polypeptide binding]; other site
999541015407	putative CheW interface [polypeptide binding]; other site
999541015408	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541015409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015410	ABC-ATPase subunit interface; other site
999541015411	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
999541015412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541015413	Walker A/P-loop; other site
999541015414	ATP binding site [chemical binding]; other site
999541015415	Q-loop/lid; other site
999541015416	ABC transporter signature motif; other site
999541015417	Walker B; other site
999541015418	D-loop; other site
999541015419	H-loop/switch region; other site
999541015420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015421	dimer interface [polypeptide binding]; other site
999541015422	conserved gate region; other site
999541015423	ABC-ATPase subunit interface; other site
999541015424	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541015425	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
999541015426	LysE type translocator; Region: LysE; cl00565
999541015427	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
999541015428	GAF domain; Region: GAF; pfam01590
999541015429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541015430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541015431	metal binding site [ion binding]; metal-binding site
999541015432	active site
999541015433	I-site; other site
999541015434	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
999541015435	Phosphoesterase family; Region: Phosphoesterase; pfam04185
999541015436	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541015437	Domain of unknown function (DUF756); Region: DUF756; pfam05506
999541015438	FOG: CBS domain [General function prediction only]; Region: COG0517
999541015439	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
999541015440	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
999541015441	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
999541015442	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
999541015443	active site
999541015444	substrate binding site [chemical binding]; other site
999541015445	Mg2+ binding site [ion binding]; other site
999541015446	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
999541015447	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
999541015448	active site
999541015449	dimer interface [polypeptide binding]; other site
999541015450	non-prolyl cis peptide bond; other site
999541015451	insertion regions; other site
999541015452	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
999541015453	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541015454	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541015455	conserved cys residue [active]
999541015456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541015457	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
999541015458	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541015459	non-specific DNA binding site [nucleotide binding]; other site
999541015460	salt bridge; other site
999541015461	sequence-specific DNA binding site [nucleotide binding]; other site
999541015462	Cupin domain; Region: Cupin_2; pfam07883
999541015463	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541015464	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541015465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
999541015466	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
999541015467	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
999541015468	Citrate transporter; Region: CitMHS; pfam03600
999541015469	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015471	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
999541015472	putative dimerization interface [polypeptide binding]; other site
999541015473	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
999541015474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541015475	substrate binding pocket [chemical binding]; other site
999541015476	membrane-bound complex binding site; other site
999541015477	hinge residues; other site
999541015478	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541015479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015480	dimer interface [polypeptide binding]; other site
999541015481	conserved gate region; other site
999541015482	putative PBP binding loops; other site
999541015483	ABC-ATPase subunit interface; other site
999541015484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541015485	dimer interface [polypeptide binding]; other site
999541015486	conserved gate region; other site
999541015487	putative PBP binding loops; other site
999541015488	ABC-ATPase subunit interface; other site
999541015489	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
999541015490	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541015491	Walker A/P-loop; other site
999541015492	ATP binding site [chemical binding]; other site
999541015493	Q-loop/lid; other site
999541015494	ABC transporter signature motif; other site
999541015495	Walker B; other site
999541015496	D-loop; other site
999541015497	H-loop/switch region; other site
999541015498	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
999541015499	active sites [active]
999541015500	tetramer interface [polypeptide binding]; other site
999541015501	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
999541015502	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541015503	DNA-binding site [nucleotide binding]; DNA binding site
999541015504	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
999541015505	urocanate hydratase; Provisional; Region: PRK05414
999541015506	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
999541015507	Peptidase family M1; Region: Peptidase_M1; pfam01433
999541015508	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
999541015509	Zn binding site [ion binding]; other site
999541015510	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541015511	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541015512	active site
999541015513	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
999541015514	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
999541015515	putative active site pocket [active]
999541015516	metal binding site [ion binding]; metal-binding site
999541015517	short chain dehydrogenase; Provisional; Region: PRK08628
999541015518	classical (c) SDRs; Region: SDR_c; cd05233
999541015519	NAD(P) binding site [chemical binding]; other site
999541015520	active site
999541015521	Domain of unknown function (DUF718); Region: DUF718; cl01281
999541015522	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
999541015523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541015524	putative substrate translocation pore; other site
999541015525	L-fucose transporter; Provisional; Region: PRK10133; cl17665
999541015526	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541015527	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541015528	DNA-binding site [nucleotide binding]; DNA binding site
999541015529	FCD domain; Region: FCD; pfam07729
999541015530	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
999541015531	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
999541015532	folate binding site [chemical binding]; other site
999541015533	NADP+ binding site [chemical binding]; other site
999541015534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541015535	HTH-like domain; Region: HTH_21; pfam13276
999541015536	Integrase core domain; Region: rve; pfam00665
999541015537	Integrase core domain; Region: rve_3; pfam13683
999541015538	Transposase; Region: HTH_Tnp_1; pfam01527
999541015539	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541015540	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541015541	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
999541015542	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
999541015543	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
999541015544	4Fe-4S binding domain; Region: Fer4; pfam00037
999541015545	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
999541015546	Cysteine-rich domain; Region: CCG; pfam02754
999541015547	Cysteine-rich domain; Region: CCG; pfam02754
999541015548	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541015549	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541015550	DNA-binding site [nucleotide binding]; DNA binding site
999541015551	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
999541015552	cytosine deaminase; Provisional; Region: PRK05985
999541015553	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
999541015554	active site
999541015555	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
999541015556	Leucine-rich repeats; other site
999541015557	Substrate binding site [chemical binding]; other site
999541015558	Leucine rich repeat; Region: LRR_8; pfam13855
999541015559	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
999541015560	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
999541015561	putative hydrophobic ligand binding site [chemical binding]; other site
999541015562	protein interface [polypeptide binding]; other site
999541015563	gate; other site
999541015564	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541015565	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541015566	active site
999541015567	catalytic tetrad [active]
999541015568	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
999541015569	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541015570	dimer interface [polypeptide binding]; other site
999541015571	active site
999541015572	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541015573	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541015574	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541015575	MarR family; Region: MarR_2; cl17246
999541015576	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541015577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541015578	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541015579	putative substrate translocation pore; other site
999541015580	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
999541015581	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541015582	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541015583	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
999541015584	Cytochrome P450; Region: p450; cl12078
999541015585	Rubredoxin [Energy production and conversion]; Region: COG1773
999541015586	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
999541015587	iron binding site [ion binding]; other site
999541015588	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
999541015589	dinuclear metal binding motif [ion binding]; other site
999541015590	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541015591	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541015592	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
999541015593	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
999541015594	putative di-iron ligands [ion binding]; other site
999541015595	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015596	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541015597	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541015598	Di-iron ligands [ion binding]; other site
999541015599	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541015600	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541015601	Di-iron ligands [ion binding]; other site
999541015602	acyl-CoA synthetase; Validated; Region: PRK05850
999541015603	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541015604	acyl-activating enzyme (AAE) consensus motif; other site
999541015605	active site
999541015606	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
999541015607	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541015608	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
999541015609	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
999541015610	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
999541015611	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
999541015612	Bacterial sugar transferase; Region: Bac_transf; pfam02397
999541015613	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541015614	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
999541015615	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
999541015616	Low molecular weight phosphatase family; Region: LMWPc; cd00115
999541015617	active site
999541015618	tyrosine kinase; Provisional; Region: PRK11519
999541015619	Chain length determinant protein; Region: Wzz; pfam02706
999541015620	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
999541015621	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
999541015622	putative ADP-binding pocket [chemical binding]; other site
999541015623	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541015624	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541015625	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541015626	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541015627	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541015628	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
999541015629	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
999541015630	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541015631	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541015632	active site
999541015633	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
999541015634	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541015635	active site
999541015636	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541015637	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541015638	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
999541015639	active site
999541015640	catalytic residues [active]
999541015641	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
999541015642	catalytic residue [active]
999541015643	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541015644	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
999541015645	putative C-terminal domain interface [polypeptide binding]; other site
999541015646	putative GSH binding site (G-site) [chemical binding]; other site
999541015647	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541015648	putative dimer interface [polypeptide binding]; other site
999541015649	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541015650	substrate binding pocket (H-site) [chemical binding]; other site
999541015651	N-terminal domain interface [polypeptide binding]; other site
999541015652	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
999541015653	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
999541015654	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
999541015655	trimer interface [polypeptide binding]; other site
999541015656	putative metal binding site [ion binding]; other site
999541015657	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541015658	Clp protease; Region: CLP_protease; pfam00574
999541015659	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
999541015660	oligomer interface [polypeptide binding]; other site
999541015661	active site residues [active]
999541015662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541015663	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541015664	Walker A motif; other site
999541015665	ATP binding site [chemical binding]; other site
999541015666	Walker B motif; other site
999541015667	arginine finger; other site
999541015668	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541015669	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541015670	trimer interface [polypeptide binding]; other site
999541015671	eyelet of channel; other site
999541015672	Predicted transcriptional regulators [Transcription]; Region: COG1695
999541015673	Transcriptional regulator PadR-like family; Region: PadR; cl17335
999541015674	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
999541015675	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
999541015676	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
999541015677	active site
999541015678	FMN binding site [chemical binding]; other site
999541015679	2,4-decadienoyl-CoA binding site; other site
999541015680	catalytic residue [active]
999541015681	4Fe-4S cluster binding site [ion binding]; other site
999541015682	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
999541015683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541015684	SnoaL-like domain; Region: SnoaL_2; pfam12680
999541015685	enoyl-CoA hydratase; Provisional; Region: PRK06142
999541015686	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541015687	substrate binding site [chemical binding]; other site
999541015688	oxyanion hole (OAH) forming residues; other site
999541015689	trimer interface [polypeptide binding]; other site
999541015690	glycogen synthase; Provisional; Region: glgA; PRK00654
999541015691	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
999541015692	ADP-binding pocket [chemical binding]; other site
999541015693	homodimer interface [polypeptide binding]; other site
999541015694	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
999541015695	catalytic triad [active]
999541015696	active site nucleophile [active]
999541015697	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
999541015698	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541015699	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
999541015700	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541015701	substrate binding pocket [chemical binding]; other site
999541015702	membrane-bound complex binding site; other site
999541015703	hinge residues; other site
999541015704	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541015705	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
999541015706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541015707	D-galactonate transporter; Region: 2A0114; TIGR00893
999541015708	putative substrate translocation pore; other site
999541015709	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
999541015710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015712	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
999541015713	putative dimerization interface [polypeptide binding]; other site
999541015714	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541015715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541015716	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015718	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541015719	dimerization interface [polypeptide binding]; other site
999541015720	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
999541015721	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
999541015722	metal binding site [ion binding]; metal-binding site
999541015723	putative dimer interface [polypeptide binding]; other site
999541015724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541015725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541015726	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541015727	putative effector binding pocket; other site
999541015728	putative dimerization interface [polypeptide binding]; other site
999541015729	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
999541015730	NAD(P) binding site [chemical binding]; other site
999541015731	active site lysine
999541015732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541015733	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541015734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541015735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541015736	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541015737	DNA binding site [nucleotide binding]
999541015738	Predicted ATPase [General function prediction only]; Region: COG3903
999541015739	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541015740	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541015741	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541015742	Isochorismatase family; Region: Isochorismatase; pfam00857
999541015743	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
999541015744	catalytic triad [active]
999541015745	dimer interface [polypeptide binding]; other site
999541015746	conserved cis-peptide bond; other site
999541015747	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
999541015748	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
999541015749	active site
999541015750	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
999541015751	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
999541015752	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
999541015753	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
999541015754	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
999541015755	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
999541015756	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
999541015757	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
999541015758	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
999541015759	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541015760	Predicted membrane protein [Function unknown]; Region: COG3059
999541015761	DDE domain; Region: DDE_Tnp_IS240; pfam13610
999541015762	Integrase core domain; Region: rve; pfam00665
999541015763	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
999541015764	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015765	Ligand Binding Site [chemical binding]; other site
999541015766	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015767	Ligand Binding Site [chemical binding]; other site
999541015768	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
999541015769	putative active site [active]
999541015770	putative metal binding site [ion binding]; other site
999541015771	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
999541015772	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
999541015773	FOG: CBS domain [General function prediction only]; Region: COG0517
999541015774	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
999541015775	BON domain; Region: BON; pfam04972
999541015776	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541015777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541015778	active site
999541015779	phosphorylation site [posttranslational modification]
999541015780	intermolecular recognition site; other site
999541015781	dimerization interface [polypeptide binding]; other site
999541015782	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541015783	DNA binding residues [nucleotide binding]
999541015784	dimerization interface [polypeptide binding]; other site
999541015785	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
999541015786	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
999541015787	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
999541015788	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541015789	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
999541015790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541015791	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541015792	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
999541015793	active site
999541015794	nucleophile elbow; other site
999541015795	Patatin phospholipase; Region: DUF3734; pfam12536
999541015796	FOG: CBS domain [General function prediction only]; Region: COG0517
999541015797	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
999541015798	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
999541015799	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541015800	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
999541015801	putative dimer interface [polypeptide binding]; other site
999541015802	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
999541015803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
999541015804	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
999541015805	substrate binding site [chemical binding]; other site
999541015806	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
999541015807	AAA domain; Region: AAA_33; pfam13671
999541015808	active site
999541015809	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
999541015810	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
999541015811	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
999541015812	putative dimer interface [polypeptide binding]; other site
999541015813	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
999541015814	putative FMN binding site [chemical binding]; other site
999541015815	NADPH bind site [chemical binding]; other site
999541015816	Cytochrome c; Region: Cytochrom_C; cl11414
999541015817	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
999541015818	FMN binding site [chemical binding]; other site
999541015819	dimer interface [polypeptide binding]; other site
999541015820	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
999541015821	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
999541015822	putative NAD(P) binding site [chemical binding]; other site
999541015823	putative substrate binding site [chemical binding]; other site
999541015824	catalytic Zn binding site [ion binding]; other site
999541015825	structural Zn binding site [ion binding]; other site
999541015826	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015827	Ligand Binding Site [chemical binding]; other site
999541015828	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015829	Ligand Binding Site [chemical binding]; other site
999541015830	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015831	Ligand Binding Site [chemical binding]; other site
999541015832	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
999541015833	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
999541015834	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
999541015835	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
999541015836	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
999541015837	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
999541015838	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
999541015839	Beta-Casp domain; Region: Beta-Casp; pfam10996
999541015840	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
999541015841	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541015842	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541015843	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
999541015844	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
999541015845	Walker A/P-loop; other site
999541015846	ATP binding site [chemical binding]; other site
999541015847	Q-loop/lid; other site
999541015848	ABC transporter signature motif; other site
999541015849	Walker B; other site
999541015850	D-loop; other site
999541015851	H-loop/switch region; other site
999541015852	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
999541015853	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
999541015854	FtsX-like permease family; Region: FtsX; pfam02687
999541015855	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
999541015856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541015857	Walker A motif; other site
999541015858	ATP binding site [chemical binding]; other site
999541015859	Walker B motif; other site
999541015860	arginine finger; other site
999541015861	Peptidase family M41; Region: Peptidase_M41; pfam01434
999541015862	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541015863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541015864	Walker A motif; other site
999541015865	ATP binding site [chemical binding]; other site
999541015866	Walker B motif; other site
999541015867	arginine finger; other site
999541015868	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541015869	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
999541015870	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541015871	ligand binding site [chemical binding]; other site
999541015872	flexible hinge region; other site
999541015873	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541015874	putative switch regulator; other site
999541015875	non-specific DNA interactions [nucleotide binding]; other site
999541015876	DNA binding site [nucleotide binding]
999541015877	sequence specific DNA binding site [nucleotide binding]; other site
999541015878	putative cAMP binding site [chemical binding]; other site
999541015879	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015880	Ligand Binding Site [chemical binding]; other site
999541015881	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
999541015882	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
999541015883	NAD(P) binding site [chemical binding]; other site
999541015884	homotetramer interface [polypeptide binding]; other site
999541015885	homodimer interface [polypeptide binding]; other site
999541015886	active site
999541015887	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015888	Ligand Binding Site [chemical binding]; other site
999541015889	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015890	Ligand Binding Site [chemical binding]; other site
999541015891	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
999541015892	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
999541015893	catalytic Zn binding site [ion binding]; other site
999541015894	structural Zn binding site [ion binding]; other site
999541015895	NAD(P) binding site [chemical binding]; other site
999541015896	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
999541015897	BON domain; Region: BON; pfam04972
999541015898	BON domain; Region: BON; pfam04972
999541015899	Domain of unknown function (DUF3449); Region: DUF3449; pfam11931
999541015900	BON domain; Region: BON; pfam04972
999541015901	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
999541015902	30S subunit binding site; other site
999541015903	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
999541015904	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541015905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541015906	active site
999541015907	phosphorylation site [posttranslational modification]
999541015908	intermolecular recognition site; other site
999541015909	dimerization interface [polypeptide binding]; other site
999541015910	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541015911	DNA binding residues [nucleotide binding]
999541015912	dimerization interface [polypeptide binding]; other site
999541015913	PAS domain S-box; Region: sensory_box; TIGR00229
999541015914	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541015915	putative active site [active]
999541015916	heme pocket [chemical binding]; other site
999541015917	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
999541015918	Histidine kinase; Region: HisKA_3; pfam07730
999541015919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541015920	ATP binding site [chemical binding]; other site
999541015921	Mg2+ binding site [ion binding]; other site
999541015922	G-X-G motif; other site
999541015923	Universal stress protein family; Region: Usp; pfam00582
999541015924	Ligand Binding Site [chemical binding]; other site
999541015925	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015926	Ligand Binding Site [chemical binding]; other site
999541015927	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015928	Ligand Binding Site [chemical binding]; other site
999541015929	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015930	Ligand Binding Site [chemical binding]; other site
999541015931	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541015932	Ligand Binding Site [chemical binding]; other site
999541015933	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
999541015934	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
999541015935	Hemerythrin-like domain; Region: Hr-like; cd12108
999541015936	Fe binding site [ion binding]; other site
999541015937	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541015938	DNA-binding site [nucleotide binding]; DNA binding site
999541015939	RNA-binding motif; other site
999541015940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541015941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541015942	Helix-turn-helix domain; Region: HTH_28; pfam13518
999541015943	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541015944	putative transposase OrfB; Reviewed; Region: PHA02517
999541015945	HTH-like domain; Region: HTH_21; pfam13276
999541015946	Integrase core domain; Region: rve; pfam00665
999541015947	Integrase core domain; Region: rve_2; pfam13333
999541015948	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541015949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541015950	S-adenosylmethionine binding site [chemical binding]; other site
999541015951	acyl carrier protein; Validated; Region: PRK07117
999541015952	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
999541015953	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541015954	substrate binding site [chemical binding]; other site
999541015955	oxyanion hole (OAH) forming residues; other site
999541015956	trimer interface [polypeptide binding]; other site
999541015957	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541015958	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
999541015959	substrate binding site [chemical binding]; other site
999541015960	oxyanion hole (OAH) forming residues; other site
999541015961	trimer interface [polypeptide binding]; other site
999541015962	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
999541015963	FMN binding site [chemical binding]; other site
999541015964	substrate binding site [chemical binding]; other site
999541015965	putative catalytic residue [active]
999541015966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541015967	S-adenosylmethionine binding site [chemical binding]; other site
999541015968	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015969	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015970	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015971	polyketide synthase; Region: polyketide_synthase; cd08251
999541015972	Enoylreductase; Region: PKS_ER; smart00829
999541015973	putative NAD(P) binding site [chemical binding]; other site
999541015974	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541015975	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541015976	active site
999541015977	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541015978	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541015979	KR domain; Region: KR; pfam08659
999541015980	putative NADP binding site [chemical binding]; other site
999541015981	active site
999541015982	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015983	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541015984	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541015985	active site
999541015986	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015987	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541015988	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541015989	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
999541015990	active site
999541015991	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541015992	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541015993	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541015994	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541015995	active site
999541015996	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541015997	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541015998	putative NADP binding site [chemical binding]; other site
999541015999	KR domain; Region: KR; pfam08659
999541016000	active site
999541016001	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541016002	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016003	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541016004	active site
999541016005	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541016006	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016007	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541016008	putative NADP binding site [chemical binding]; other site
999541016009	active site
999541016010	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016011	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016012	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016013	active site
999541016014	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541016015	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016016	putative NADP binding site [chemical binding]; other site
999541016017	KR domain; Region: KR; pfam08659
999541016018	active site
999541016019	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016020	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016021	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016022	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016023	active site
999541016024	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016025	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016026	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016027	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016028	active site
999541016029	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541016030	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016031	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541016032	putative NADP binding site [chemical binding]; other site
999541016033	active site
999541016034	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541016035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541016036	S-adenosylmethionine binding site [chemical binding]; other site
999541016037	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016038	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016039	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016040	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016041	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016042	active site
999541016043	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016044	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541016045	putative NADP binding site [chemical binding]; other site
999541016046	active site
999541016047	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541016048	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541016049	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016050	active site
999541016051	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
999541016052	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016053	KR domain; Region: KR; pfam08659
999541016054	putative NADP binding site [chemical binding]; other site
999541016055	active site
999541016056	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541016057	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016058	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016059	active site
999541016060	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541016061	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541016062	putative NADP binding site [chemical binding]; other site
999541016063	active site
999541016064	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541016065	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541016066	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541016067	active site
999541016068	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
999541016069	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
999541016070	dimer interface [polypeptide binding]; other site
999541016071	active site
999541016072	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
999541016073	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
999541016074	dimer interface [polypeptide binding]; other site
999541016075	active site
999541016076	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
999541016077	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541016078	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541016079	Acyl transferase domain; Region: Acyl_transf_1; cl08282
999541016080	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
999541016081	Cytochrome P450; Region: p450; cl12078
999541016082	Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135
999541016083	Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135
999541016084	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
999541016085	FRG domain; Region: FRG; pfam08867
999541016086	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541016087	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541016088	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541016089	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541016090	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541016091	DNA binding site [nucleotide binding]
999541016092	domain linker motif; other site
999541016093	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
999541016094	putative dimerization interface [polypeptide binding]; other site
999541016095	putative ligand binding site [chemical binding]; other site
999541016096	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
999541016097	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
999541016098	putative ligand binding site [chemical binding]; other site
999541016099	NAD binding site [chemical binding]; other site
999541016100	catalytic site [active]
999541016101	short chain dehydrogenase; Provisional; Region: PRK07326
999541016102	classical (c) SDRs; Region: SDR_c; cd05233
999541016103	NAD(P) binding site [chemical binding]; other site
999541016104	active site
999541016105	EthD domain; Region: EthD; cl17553
999541016106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541016107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541016108	putative substrate translocation pore; other site
999541016109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541016110	L-asparaginase II; Region: Asparaginase_II; pfam06089
999541016111	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
999541016112	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
999541016113	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541016114	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
999541016115	putative active site [active]
999541016116	putative metal binding site [ion binding]; other site
999541016117	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
999541016118	active site
999541016119	metal binding site [ion binding]; metal-binding site
999541016120	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
999541016121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541016122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541016123	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
999541016124	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
999541016125	NADP binding site [chemical binding]; other site
999541016126	dimer interface [polypeptide binding]; other site
999541016127	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541016128	Coenzyme A binding pocket [chemical binding]; other site
999541016129	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
999541016130	RNA polymerase sigma factor; Provisional; Region: PRK12547
999541016131	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541016132	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541016133	DNA binding residues [nucleotide binding]
999541016134	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
999541016135	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541016136	PAS domain; Region: PAS_9; pfam13426
999541016137	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541016138	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541016139	metal binding site [ion binding]; metal-binding site
999541016140	active site
999541016141	I-site; other site
999541016142	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541016143	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541016144	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
999541016145	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
999541016146	active site
999541016147	metal binding site [ion binding]; metal-binding site
999541016148	Phage integrase protein; Region: DUF3701; pfam12482
999541016149	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
999541016150	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541016151	active site
999541016152	DNA binding site [nucleotide binding]
999541016153	Int/Topo IB signature motif; other site
999541016154	Alginate lyase; Region: Alginate_lyase2; pfam08787
999541016155	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
999541016156	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
999541016157	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
999541016158	substrate binding site [chemical binding]; other site
999541016159	THF binding site; other site
999541016160	zinc-binding site [ion binding]; other site
999541016161	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
999541016162	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
999541016163	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541016164	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541016165	NAD(P) binding site [chemical binding]; other site
999541016166	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541016167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541016168	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
999541016169	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
999541016170	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
999541016171	Predicted integral membrane protein [Function unknown]; Region: COG0392
999541016172	Uncharacterized conserved protein [Function unknown]; Region: COG2898
999541016173	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
999541016174	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
999541016175	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
999541016176	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
999541016177	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541016178	YciI-like protein; Reviewed; Region: PRK12866
999541016179	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
999541016180	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
999541016181	oligomer interface [polypeptide binding]; other site
999541016182	metal binding site [ion binding]; metal-binding site
999541016183	metal binding site [ion binding]; metal-binding site
999541016184	putative Cl binding site [ion binding]; other site
999541016185	basic sphincter; other site
999541016186	hydrophobic gate; other site
999541016187	periplasmic entrance; other site
999541016188	AAA domain; Region: AAA_33; pfam13671
999541016189	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
999541016190	active site
999541016191	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
999541016192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541016193	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541016194	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
999541016195	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541016196	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541016197	ligand binding site [chemical binding]; other site
999541016198	flexible hinge region; other site
999541016199	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541016200	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
999541016201	AsnC family; Region: AsnC_trans_reg; pfam01037
999541016202	LTXXQ motif family protein; Region: LTXXQ; pfam07813
999541016203	PGDYG protein; Region: PGDYG; pfam14083
999541016204	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
999541016205	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
999541016206	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541016207	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541016208	DNA binding site [nucleotide binding]
999541016209	domain linker motif; other site
999541016210	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541016211	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541016212	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541016213	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
999541016214	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
999541016215	dimerization interface [polypeptide binding]; other site
999541016216	ligand binding site [chemical binding]; other site
999541016217	NADP binding site [chemical binding]; other site
999541016218	catalytic site [active]
999541016219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541016220	D-galactonate transporter; Region: 2A0114; TIGR00893
999541016221	putative substrate translocation pore; other site
999541016222	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
999541016223	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541016224	substrate binding site [chemical binding]; other site
999541016225	ATP binding site [chemical binding]; other site
999541016226	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541016227	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
999541016228	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
999541016229	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
999541016230	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
999541016231	PapC N-terminal domain; Region: PapC_N; pfam13954
999541016232	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
999541016233	PapC C-terminal domain; Region: PapC_C; pfam13953
999541016234	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541016235	putative major fimbrial protein SthE; Provisional; Region: PRK15292
999541016236	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541016237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541016238	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
999541016239	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
999541016240	putative dimerization interface [polypeptide binding]; other site
999541016241	Predicted membrane protein [Function unknown]; Region: COG2855
999541016242	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
999541016243	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
999541016244	Cl- selectivity filter; other site
999541016245	Cl- binding residues [ion binding]; other site
999541016246	pore gating glutamate residue; other site
999541016247	dimer interface [polypeptide binding]; other site
999541016248	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
999541016249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541016250	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541016251	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541016252	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541016253	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541016254	Outer membrane efflux protein; Region: OEP; pfam02321
999541016255	Domain of unknown function DUF; Region: DUF204; pfam02659
999541016256	Domain of unknown function DUF; Region: DUF204; pfam02659
999541016257	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541016258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541016259	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541016260	putative effector binding pocket; other site
999541016261	dimerization interface [polypeptide binding]; other site
999541016262	PAS fold; Region: PAS_4; pfam08448
999541016263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016264	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541016265	Walker A motif; other site
999541016266	ATP binding site [chemical binding]; other site
999541016267	Walker B motif; other site
999541016268	arginine finger; other site
999541016269	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541016270	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
999541016271	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
999541016272	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
999541016273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541016274	dimer interface [polypeptide binding]; other site
999541016275	conserved gate region; other site
999541016276	putative PBP binding loops; other site
999541016277	ABC-ATPase subunit interface; other site
999541016278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541016279	dimer interface [polypeptide binding]; other site
999541016280	conserved gate region; other site
999541016281	putative PBP binding loops; other site
999541016282	ABC-ATPase subunit interface; other site
999541016283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541016284	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
999541016285	Walker A/P-loop; other site
999541016286	ATP binding site [chemical binding]; other site
999541016287	Q-loop/lid; other site
999541016288	ABC transporter signature motif; other site
999541016289	Walker B; other site
999541016290	D-loop; other site
999541016291	H-loop/switch region; other site
999541016292	TOBE domain; Region: TOBE_2; pfam08402
999541016293	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
999541016294	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
999541016295	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
999541016296	substrate binding site [chemical binding]; other site
999541016297	dimerization interface [polypeptide binding]; other site
999541016298	active site
999541016299	calcium binding site [ion binding]; other site
999541016300	Predicted Fe-S protein [General function prediction only]; Region: COG3313
999541016301	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
999541016302	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
999541016303	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
999541016304	FMN binding site [chemical binding]; other site
999541016305	substrate binding site [chemical binding]; other site
999541016306	putative catalytic residue [active]
999541016307	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541016308	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
999541016309	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541016310	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541016311	ABC transporter; Region: ABC_tran_2; pfam12848
999541016312	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541016313	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
999541016314	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
999541016315	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
999541016316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541016317	Walker A/P-loop; other site
999541016318	ATP binding site [chemical binding]; other site
999541016319	Q-loop/lid; other site
999541016320	ABC transporter signature motif; other site
999541016321	Walker B; other site
999541016322	D-loop; other site
999541016323	H-loop/switch region; other site
999541016324	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
999541016325	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
999541016326	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
999541016327	putative NAD(P) binding site [chemical binding]; other site
999541016328	dimer interface [polypeptide binding]; other site
999541016329	transcriptional activator TtdR; Provisional; Region: PRK09801
999541016330	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541016331	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541016332	putative effector binding pocket; other site
999541016333	dimerization interface [polypeptide binding]; other site
999541016334	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
999541016335	phosphoserine phosphatase SerB; Region: serB; TIGR00338
999541016336	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
999541016337	cystathionine beta-lyase; Provisional; Region: PRK07050
999541016338	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541016339	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541016340	catalytic residue [active]
999541016341	beta-ketothiolase; Provisional; Region: PRK09051
999541016342	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541016343	dimer interface [polypeptide binding]; other site
999541016344	active site
999541016345	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
999541016346	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541016347	substrate binding site [chemical binding]; other site
999541016348	ATP binding site [chemical binding]; other site
999541016349	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
999541016350	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
999541016351	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541016352	FeS/SAM binding site; other site
999541016353	TRAM domain; Region: TRAM; cl01282
999541016354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541016355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541016356	active site
999541016357	phosphorylation site [posttranslational modification]
999541016358	intermolecular recognition site; other site
999541016359	dimerization interface [polypeptide binding]; other site
999541016360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541016361	DNA binding site [nucleotide binding]
999541016362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
999541016363	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
999541016364	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
999541016365	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
999541016366	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
999541016367	NAD(P) binding site [chemical binding]; other site
999541016368	homotetramer interface [polypeptide binding]; other site
999541016369	homodimer interface [polypeptide binding]; other site
999541016370	active site
999541016371	putative acyltransferase; Provisional; Region: PRK05790
999541016372	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541016373	dimer interface [polypeptide binding]; other site
999541016374	active site
999541016375	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
999541016376	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
999541016377	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
999541016378	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
999541016379	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
999541016380	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541016381	RNA binding surface [nucleotide binding]; other site
999541016382	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
999541016383	active site
999541016384	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
999541016385	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
999541016386	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
999541016387	DEAD_2; Region: DEAD_2; pfam06733
999541016388	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
999541016389	Protein of unknown function (DUF465); Region: DUF465; cl01070
999541016390	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
999541016391	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
999541016392	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
999541016393	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
999541016394	RNA binding site [nucleotide binding]; other site
999541016395	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
999541016396	potassium uptake protein; Region: kup; TIGR00794
999541016397	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
999541016398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541016399	active site
999541016400	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
999541016401	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
999541016402	GDP-binding site [chemical binding]; other site
999541016403	ACT binding site; other site
999541016404	IMP binding site; other site
999541016405	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
999541016406	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
999541016407	dimer interface [polypeptide binding]; other site
999541016408	motif 1; other site
999541016409	active site
999541016410	motif 2; other site
999541016411	motif 3; other site
999541016412	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
999541016413	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
999541016414	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
999541016415	HflK protein; Region: hflK; TIGR01933
999541016416	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
999541016417	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
999541016418	HflX GTPase family; Region: HflX; cd01878
999541016419	G1 box; other site
999541016420	GTP/Mg2+ binding site [chemical binding]; other site
999541016421	Switch I region; other site
999541016422	G2 box; other site
999541016423	G3 box; other site
999541016424	Switch II region; other site
999541016425	G4 box; other site
999541016426	G5 box; other site
999541016427	bacterial Hfq-like; Region: Hfq; cd01716
999541016428	hexamer interface [polypeptide binding]; other site
999541016429	Sm1 motif; other site
999541016430	RNA binding site [nucleotide binding]; other site
999541016431	Sm2 motif; other site
999541016432	GTP-binding protein Der; Reviewed; Region: PRK00093
999541016433	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
999541016434	G1 box; other site
999541016435	GTP/Mg2+ binding site [chemical binding]; other site
999541016436	Switch I region; other site
999541016437	G2 box; other site
999541016438	Switch II region; other site
999541016439	G3 box; other site
999541016440	G4 box; other site
999541016441	G5 box; other site
999541016442	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
999541016443	G1 box; other site
999541016444	GTP/Mg2+ binding site [chemical binding]; other site
999541016445	Switch I region; other site
999541016446	G2 box; other site
999541016447	G3 box; other site
999541016448	Switch II region; other site
999541016449	G4 box; other site
999541016450	G5 box; other site
999541016451	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
999541016452	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
999541016453	Trp docking motif [polypeptide binding]; other site
999541016454	active site
999541016455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
999541016456	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
999541016457	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
999541016458	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
999541016459	dimer interface [polypeptide binding]; other site
999541016460	motif 1; other site
999541016461	active site
999541016462	motif 2; other site
999541016463	motif 3; other site
999541016464	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
999541016465	anticodon binding site; other site
999541016466	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
999541016467	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
999541016468	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
999541016469	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541016470	non-specific DNA binding site [nucleotide binding]; other site
999541016471	salt bridge; other site
999541016472	sequence-specific DNA binding site [nucleotide binding]; other site
999541016473	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
999541016474	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
999541016475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541016476	FeS/SAM binding site; other site
999541016477	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
999541016478	active site
999541016479	multimer interface [polypeptide binding]; other site
999541016480	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
999541016481	YccA-like proteins; Region: YccA_like; cd10433
999541016482	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
999541016483	TRAM domain; Region: TRAM; cl01282
999541016484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541016485	S-adenosylmethionine binding site [chemical binding]; other site
999541016486	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
999541016487	putative catalytic site [active]
999541016488	putative metal binding site [ion binding]; other site
999541016489	putative phosphate binding site [ion binding]; other site
999541016490	putative catalytic site [active]
999541016491	putative phosphate binding site [ion binding]; other site
999541016492	putative metal binding site [ion binding]; other site
999541016493	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
999541016494	active site
999541016495	catalytic site [active]
999541016496	substrate binding site [chemical binding]; other site
999541016497	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
999541016498	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
999541016499	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
999541016500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541016501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541016502	DNA binding residues [nucleotide binding]
999541016503	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
999541016504	Peptidase family M23; Region: Peptidase_M23; pfam01551
999541016505	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
999541016506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541016507	S-adenosylmethionine binding site [chemical binding]; other site
999541016508	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
999541016509	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541016510	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541016511	recombination protein RecR; Reviewed; Region: recR; PRK00076
999541016512	RecR protein; Region: RecR; pfam02132
999541016513	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
999541016514	putative active site [active]
999541016515	putative metal-binding site [ion binding]; other site
999541016516	tetramer interface [polypeptide binding]; other site
999541016517	hypothetical protein; Validated; Region: PRK00153
999541016518	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
999541016519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016520	Walker A motif; other site
999541016521	ATP binding site [chemical binding]; other site
999541016522	Walker B motif; other site
999541016523	arginine finger; other site
999541016524	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
999541016525	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
999541016526	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541016527	catalytic residues [active]
999541016528	transcription termination factor Rho; Provisional; Region: rho; PRK09376
999541016529	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
999541016530	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
999541016531	RNA binding site [nucleotide binding]; other site
999541016532	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
999541016533	multimer interface [polypeptide binding]; other site
999541016534	Walker A motif; other site
999541016535	ATP binding site [chemical binding]; other site
999541016536	Walker B motif; other site
999541016537	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
999541016538	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
999541016539	DNA binding residues [nucleotide binding]
999541016540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541016541	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541016542	putative substrate translocation pore; other site
999541016543	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
999541016544	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
999541016545	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
999541016546	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
999541016547	multidrug efflux protein; Reviewed; Region: PRK01766
999541016548	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
999541016549	cation binding site [ion binding]; other site
999541016550	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
999541016551	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
999541016552	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
999541016553	Clp amino terminal domain; Region: Clp_N; pfam02861
999541016554	Clp amino terminal domain; Region: Clp_N; pfam02861
999541016555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016556	Walker A motif; other site
999541016557	ATP binding site [chemical binding]; other site
999541016558	Walker B motif; other site
999541016559	arginine finger; other site
999541016560	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016561	Walker A motif; other site
999541016562	ATP binding site [chemical binding]; other site
999541016563	Walker B motif; other site
999541016564	arginine finger; other site
999541016565	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
999541016566	Transcriptional regulator; Region: Rrf2; cl17282
999541016567	Rrf2 family protein; Region: rrf2_super; TIGR00738
999541016568	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
999541016569	apolar tunnel; other site
999541016570	heme binding site [chemical binding]; other site
999541016571	dimerization interface [polypeptide binding]; other site
999541016572	DnaJ domain; Region: DnaJ; pfam00226
999541016573	HSP70 interaction site [polypeptide binding]; other site
999541016574	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
999541016575	MoaE homodimer interface [polypeptide binding]; other site
999541016576	MoaD interaction [polypeptide binding]; other site
999541016577	active site residues [active]
999541016578	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
999541016579	MoaE interaction surface [polypeptide binding]; other site
999541016580	MoeB interaction surface [polypeptide binding]; other site
999541016581	thiocarboxylated glycine; other site
999541016582	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
999541016583	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
999541016584	dimer interface [polypeptide binding]; other site
999541016585	putative functional site; other site
999541016586	putative MPT binding site; other site
999541016587	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
999541016588	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
999541016589	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541016590	catalytic residue [active]
999541016591	homoserine dehydrogenase; Provisional; Region: PRK06349
999541016592	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
999541016593	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
999541016594	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
999541016595	aminotransferase AlaT; Validated; Region: PRK09265
999541016596	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541016597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541016598	homodimer interface [polypeptide binding]; other site
999541016599	catalytic residue [active]
999541016600	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
999541016601	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
999541016602	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
999541016603	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
999541016604	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
999541016605	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
999541016606	inhibitor-cofactor binding pocket; inhibition site
999541016607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541016608	catalytic residue [active]
999541016609	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
999541016610	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
999541016611	Ligand binding site; other site
999541016612	Putative Catalytic site; other site
999541016613	DXD motif; other site
999541016614	putative formyltransferase; Provisional; Region: PRK06988
999541016615	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
999541016616	active site
999541016617	substrate binding site [chemical binding]; other site
999541016618	cosubstrate binding site; other site
999541016619	catalytic site [active]
999541016620	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
999541016621	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
999541016622	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
999541016623	NAD binding site [chemical binding]; other site
999541016624	substrate binding site [chemical binding]; other site
999541016625	active site
999541016626	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
999541016627	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
999541016628	putative active site [active]
999541016629	putative catalytic site [active]
999541016630	putative Zn binding site [ion binding]; other site
999541016631	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
999541016632	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541016633	catalytic triad [active]
999541016634	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
999541016635	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
999541016636	putative active site [active]
999541016637	PhoH-like protein; Region: PhoH; pfam02562
999541016638	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
999541016639	NlpC/P60 family; Region: NLPC_P60; pfam00877
999541016640	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541016641	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541016642	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541016643	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541016644	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541016645	substrate binding pocket [chemical binding]; other site
999541016646	membrane-bound complex binding site; other site
999541016647	hinge residues; other site
999541016648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541016649	dimer interface [polypeptide binding]; other site
999541016650	conserved gate region; other site
999541016651	putative PBP binding loops; other site
999541016652	ABC-ATPase subunit interface; other site
999541016653	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541016654	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541016655	Walker A/P-loop; other site
999541016656	ATP binding site [chemical binding]; other site
999541016657	Q-loop/lid; other site
999541016658	ABC transporter signature motif; other site
999541016659	Walker B; other site
999541016660	D-loop; other site
999541016661	H-loop/switch region; other site
999541016662	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541016663	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541016664	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
999541016665	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
999541016666	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
999541016667	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541016668	Walker A motif; other site
999541016669	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
999541016670	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
999541016671	ATP binding site [chemical binding]; other site
999541016672	Walker B motif; other site
999541016673	DNA binding loops [nucleotide binding]
999541016674	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
999541016675	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
999541016676	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
999541016677	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
999541016678	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
999541016679	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
999541016680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541016681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541016682	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541016683	putative effector binding pocket; other site
999541016684	dimerization interface [polypeptide binding]; other site
999541016685	glyoxylate carboligase; Provisional; Region: PRK11269
999541016686	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541016687	PYR/PP interface [polypeptide binding]; other site
999541016688	dimer interface [polypeptide binding]; other site
999541016689	TPP binding site [chemical binding]; other site
999541016690	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541016691	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
999541016692	TPP-binding site [chemical binding]; other site
999541016693	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
999541016694	tartronate semialdehyde reductase; Provisional; Region: PRK15059
999541016695	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541016696	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
999541016697	active site
999541016698	homotetramer interface [polypeptide binding]; other site
999541016699	homodimer interface [polypeptide binding]; other site
999541016700	psiF repeat; Region: PsiF_repeat; pfam07769
999541016701	psiF repeat; Region: PsiF_repeat; pfam07769
999541016702	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
999541016703	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
999541016704	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541016705	putative ADP-binding pocket [chemical binding]; other site
999541016706	Predicted ATPase [General function prediction only]; Region: COG4637
999541016707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541016708	Walker A/P-loop; other site
999541016709	ATP binding site [chemical binding]; other site
999541016710	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
999541016711	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541016712	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
999541016713	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
999541016714	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
999541016715	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
999541016716	active site
999541016717	DNA polymerase III subunit delta'; Validated; Region: PRK06964
999541016718	DNA polymerase III subunit delta'; Validated; Region: PRK08485
999541016719	thymidylate kinase; Validated; Region: tmk; PRK00698
999541016720	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
999541016721	TMP-binding site; other site
999541016722	ATP-binding site [chemical binding]; other site
999541016723	YceG-like family; Region: YceG; pfam02618
999541016724	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
999541016725	dimerization interface [polypeptide binding]; other site
999541016726	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
999541016727	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
999541016728	NRDE protein; Region: NRDE; cl01315
999541016729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541016730	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
999541016731	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541016732	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
999541016733	Prostaglandin dehydrogenases; Region: PGDH; cd05288
999541016734	NAD(P) binding site [chemical binding]; other site
999541016735	substrate binding site [chemical binding]; other site
999541016736	dimer interface [polypeptide binding]; other site
999541016737	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541016738	CoenzymeA binding site [chemical binding]; other site
999541016739	subunit interaction site [polypeptide binding]; other site
999541016740	PHB binding site; other site
999541016741	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
999541016742	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541016743	dimer interface [polypeptide binding]; other site
999541016744	active site
999541016745	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
999541016746	catalytic triad [active]
999541016747	metal binding site [ion binding]; metal-binding site
999541016748	conserved cis-peptide bond; other site
999541016749	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541016750	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
999541016751	substrate binding site [chemical binding]; other site
999541016752	oxyanion hole (OAH) forming residues; other site
999541016753	trimer interface [polypeptide binding]; other site
999541016754	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
999541016755	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541016756	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541016757	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
999541016758	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
999541016759	dimer interface [polypeptide binding]; other site
999541016760	acyl-activating enzyme (AAE) consensus motif; other site
999541016761	putative active site [active]
999541016762	AMP binding site [chemical binding]; other site
999541016763	putative CoA binding site [chemical binding]; other site
999541016764	hypothetical protein; Validated; Region: PRK00029
999541016765	Uncharacterized conserved protein [Function unknown]; Region: COG0397
999541016766	methionine sulfoxide reductase B; Provisional; Region: PRK00222
999541016767	SelR domain; Region: SelR; pfam01641
999541016768	intracellular septation protein A; Reviewed; Region: PRK00259
999541016769	BolA-like protein; Region: BolA; pfam01722
999541016770	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
999541016771	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
999541016772	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
999541016773	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
999541016774	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
999541016775	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
999541016776	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
999541016777	dimerization interface [polypeptide binding]; other site
999541016778	ATP binding site [chemical binding]; other site
999541016779	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
999541016780	dimerization interface [polypeptide binding]; other site
999541016781	ATP binding site [chemical binding]; other site
999541016782	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
999541016783	putative active site [active]
999541016784	catalytic triad [active]
999541016785	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
999541016786	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
999541016787	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
999541016788	putative substrate binding site [chemical binding]; other site
999541016789	putative ATP binding site [chemical binding]; other site
999541016790	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
999541016791	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
999541016792	active site
999541016793	dimer interface [polypeptide binding]; other site
999541016794	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
999541016795	dimer interface [polypeptide binding]; other site
999541016796	active site
999541016797	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
999541016798	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
999541016799	Walker A/P-loop; other site
999541016800	ATP binding site [chemical binding]; other site
999541016801	Q-loop/lid; other site
999541016802	ABC transporter signature motif; other site
999541016803	Walker B; other site
999541016804	D-loop; other site
999541016805	H-loop/switch region; other site
999541016806	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
999541016807	active site
999541016808	catalytic triad [active]
999541016809	oxyanion hole [active]
999541016810	switch loop; other site
999541016811	SurA N-terminal domain; Region: SurA_N_3; cl07813
999541016812	periplasmic folding chaperone; Provisional; Region: PRK10788
999541016813	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
999541016814	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
999541016815	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541016816	FAD binding domain; Region: FAD_binding_4; pfam01565
999541016817	Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129
999541016818	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
999541016819	IHF dimer interface [polypeptide binding]; other site
999541016820	IHF - DNA interface [nucleotide binding]; other site
999541016821	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
999541016822	Found in ATP-dependent protease La (LON); Region: LON; smart00464
999541016823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016824	Walker A motif; other site
999541016825	ATP binding site [chemical binding]; other site
999541016826	Walker B motif; other site
999541016827	arginine finger; other site
999541016828	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
999541016829	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
999541016830	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
999541016831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541016832	Walker A motif; other site
999541016833	ATP binding site [chemical binding]; other site
999541016834	Walker B motif; other site
999541016835	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
999541016836	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
999541016837	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
999541016838	oligomer interface [polypeptide binding]; other site
999541016839	active site residues [active]
999541016840	trigger factor; Provisional; Region: tig; PRK01490
999541016841	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
999541016842	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
999541016843	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
999541016844	MarR family; Region: MarR_2; cl17246
999541016845	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541016846	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
999541016847	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541016848	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541016849	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
999541016850	CsbD-like; Region: CsbD; cl17424
999541016851	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
999541016852	active site
999541016853	catalytic residues [active]
999541016854	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541016855	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541016856	DNA binding site [nucleotide binding]
999541016857	domain linker motif; other site
999541016858	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
999541016859	putative ligand binding site [chemical binding]; other site
999541016860	putative dimerization interface [polypeptide binding]; other site
999541016861	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
999541016862	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
999541016863	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
999541016864	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541016865	Walker A/P-loop; other site
999541016866	ATP binding site [chemical binding]; other site
999541016867	Q-loop/lid; other site
999541016868	ABC transporter signature motif; other site
999541016869	Walker B; other site
999541016870	D-loop; other site
999541016871	H-loop/switch region; other site
999541016872	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541016873	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541016874	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541016875	TM-ABC transporter signature motif; other site
999541016876	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
999541016877	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541016878	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
999541016879	TM-ABC transporter signature motif; other site
999541016880	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
999541016881	active site lid residues [active]
999541016882	substrate binding pocket [chemical binding]; other site
999541016883	catalytic residues [active]
999541016884	substrate-Mg2+ binding site; other site
999541016885	aspartate-rich region 1; other site
999541016886	aspartate-rich region 2; other site
999541016887	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
999541016888	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
999541016889	osmolarity response regulator; Provisional; Region: ompR; PRK09468
999541016890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541016891	active site
999541016892	phosphorylation site [posttranslational modification]
999541016893	intermolecular recognition site; other site
999541016894	dimerization interface [polypeptide binding]; other site
999541016895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541016896	DNA binding site [nucleotide binding]
999541016897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541016898	dimer interface [polypeptide binding]; other site
999541016899	phosphorylation site [posttranslational modification]
999541016900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541016901	ATP binding site [chemical binding]; other site
999541016902	Mg2+ binding site [ion binding]; other site
999541016903	G-X-G motif; other site
999541016904	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
999541016905	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
999541016906	dimer interface [polypeptide binding]; other site
999541016907	decamer (pentamer of dimers) interface [polypeptide binding]; other site
999541016908	catalytic triad [active]
999541016909	peroxidatic and resolving cysteines [active]
999541016910	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
999541016911	homotrimer interaction site [polypeptide binding]; other site
999541016912	zinc binding site [ion binding]; other site
999541016913	CDP-binding sites; other site
999541016914	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
999541016915	substrate binding site; other site
999541016916	dimer interface; other site
999541016917	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
999541016918	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
999541016919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541016920	ATP binding site [chemical binding]; other site
999541016921	putative Mg++ binding site [ion binding]; other site
999541016922	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541016923	nucleotide binding region [chemical binding]; other site
999541016924	ATP-binding site [chemical binding]; other site
999541016925	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
999541016926	acetylornithine deacetylase; Provisional; Region: PRK07522
999541016927	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
999541016928	metal binding site [ion binding]; metal-binding site
999541016929	putative dimer interface [polypeptide binding]; other site
999541016930	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
999541016931	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
999541016932	tetramer interface [polypeptide binding]; other site
999541016933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541016934	catalytic residue [active]
999541016935	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
999541016936	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
999541016937	Transglycosylase; Region: Transgly; pfam00912
999541016938	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541016939	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
999541016940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541016941	TPR repeat; Region: TPR_11; pfam13414
999541016942	TPR motif; other site
999541016943	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
999541016944	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
999541016945	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
999541016946	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
999541016947	Dodecin; Region: Dodecin; pfam07311
999541016948	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541016949	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541016950	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
999541016951	putative substrate binding pocket [chemical binding]; other site
999541016952	putative dimerization interface [polypeptide binding]; other site
999541016953	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
999541016954	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
999541016955	active site
999541016956	putative substrate binding pocket [chemical binding]; other site
999541016957	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
999541016958	active site
999541016959	homotetramer interface [polypeptide binding]; other site
999541016960	Predicted membrane protein [Function unknown]; Region: COG3748
999541016961	Protein of unknown function (DUF989); Region: DUF989; pfam06181
999541016962	Cytochrome c; Region: Cytochrom_C; pfam00034
999541016963	ureidoglycolate hydrolase; Provisional; Region: PRK03606
999541016964	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
999541016965	allantoicase; Provisional; Region: PRK13257
999541016966	Allantoicase repeat; Region: Allantoicase; pfam03561
999541016967	Allantoicase repeat; Region: Allantoicase; pfam03561
999541016968	OHCU decarboxylase; Region: UHCUDC; TIGR03164
999541016969	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
999541016970	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
999541016971	active site
999541016972	catalytic site [active]
999541016973	tetramer interface [polypeptide binding]; other site
999541016974	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
999541016975	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
999541016976	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541016977	Na binding site [ion binding]; other site
999541016978	putative substrate binding site [chemical binding]; other site
999541016979	Transcriptional regulators [Transcription]; Region: GntR; COG1802
999541016980	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541016981	DNA-binding site [nucleotide binding]; DNA binding site
999541016982	FCD domain; Region: FCD; pfam07729
999541016983	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
999541016984	dimer interface [polypeptide binding]; other site
999541016985	catalytic triad [active]
999541016986	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
999541016987	nucleoside/Zn binding site; other site
999541016988	dimer interface [polypeptide binding]; other site
999541016989	catalytic motif [active]
999541016990	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
999541016991	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541016992	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541016993	active site
999541016994	catalytic tetrad [active]
999541016995	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
999541016996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541016997	NAD(P) binding site [chemical binding]; other site
999541016998	active site
999541016999	oxidoreductase; Provisional; Region: PRK06196
999541017000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541017001	NAD(P) binding site [chemical binding]; other site
999541017002	active site
999541017003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541017004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017005	MarR family; Region: MarR_2; pfam12802
999541017006	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
999541017007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541017008	NAD(P) binding site [chemical binding]; other site
999541017009	active site
999541017010	short chain dehydrogenase; Provisional; Region: PRK06197
999541017011	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
999541017012	putative NAD(P) binding site [chemical binding]; other site
999541017013	active site
999541017014	short chain dehydrogenase; Provisional; Region: PRK06180
999541017015	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541017016	NADP binding site [chemical binding]; other site
999541017017	active site
999541017018	steroid binding site; other site
999541017019	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541017020	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017021	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541017022	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
999541017023	inhibitor site; inhibition site
999541017024	active site
999541017025	dimer interface [polypeptide binding]; other site
999541017026	catalytic residue [active]
999541017027	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
999541017028	intersubunit interface [polypeptide binding]; other site
999541017029	active site
999541017030	Zn2+ binding site [ion binding]; other site
999541017031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541017032	sequence-specific DNA binding site [nucleotide binding]; other site
999541017033	salt bridge; other site
999541017034	Cupin domain; Region: Cupin_2; pfam07883
999541017035	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
999541017036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017037	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541017038	dimerization interface [polypeptide binding]; other site
999541017039	substrate binding pocket [chemical binding]; other site
999541017040	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
999541017041	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
999541017042	active site
999541017043	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
999541017044	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
999541017045	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
999541017046	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
999541017047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541017048	NAD(P) binding site [chemical binding]; other site
999541017049	active site
999541017050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541017051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017052	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
999541017053	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541017054	Na binding site [ion binding]; other site
999541017055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017056	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
999541017057	Coenzyme A binding pocket [chemical binding]; other site
999541017058	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541017059	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
999541017060	putative C-terminal domain interface [polypeptide binding]; other site
999541017061	putative GSH binding site (G-site) [chemical binding]; other site
999541017062	putative dimer interface [polypeptide binding]; other site
999541017063	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
999541017064	putative N-terminal domain interface [polypeptide binding]; other site
999541017065	putative dimer interface [polypeptide binding]; other site
999541017066	putative substrate binding pocket (H-site) [chemical binding]; other site
999541017067	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541017068	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017069	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541017070	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
999541017071	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
999541017072	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
999541017073	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541017074	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541017075	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541017076	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541017077	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541017078	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541017079	active site
999541017080	catalytic tetrad [active]
999541017081	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541017082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017083	LysR substrate binding domain; Region: LysR_substrate; pfam03466
999541017084	dimerization interface [polypeptide binding]; other site
999541017085	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
999541017086	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
999541017087	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
999541017088	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
999541017089	conserved cys residue [active]
999541017090	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017091	SnoaL-like domain; Region: SnoaL_3; pfam13474
999541017092	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
999541017093	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
999541017094	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
999541017095	conserved cys residue [active]
999541017096	short chain dehydrogenase; Provisional; Region: PRK06500
999541017097	classical (c) SDRs; Region: SDR_c; cd05233
999541017098	NAD(P) binding site [chemical binding]; other site
999541017099	active site
999541017100	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
999541017101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541017102	FeS/SAM binding site; other site
999541017103	Domain of unknown function (DUF4130; Region: DUF4130; pfam13566
999541017104	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
999541017105	Fe-S cluster binding site [ion binding]; other site
999541017106	active site
999541017107	Protein of unknown function DUF72; Region: DUF72; pfam01904
999541017108	AAA domain; Region: AAA_11; pfam13086
999541017109	Part of AAA domain; Region: AAA_19; pfam13245
999541017110	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
999541017111	AAA domain; Region: AAA_12; pfam13087
999541017112	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
999541017113	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
999541017114	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
999541017115	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
999541017116	AAA ATPase domain; Region: AAA_15; pfam13175
999541017117	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
999541017118	active site
999541017119	metal binding site [ion binding]; metal-binding site
999541017120	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
999541017121	Part of AAA domain; Region: AAA_19; pfam13245
999541017122	Family description; Region: UvrD_C_2; pfam13538
999541017123	Uncharacterized conserved small protein [Function unknown]; Region: COG5639
999541017124	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
999541017125	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
999541017126	VirB7 interaction site; other site
999541017127	conjugal transfer protein TrbF; Provisional; Region: PRK13872
999541017128	conjugal transfer protein TrbL; Provisional; Region: PRK13875
999541017129	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
999541017130	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
999541017131	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
999541017132	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
999541017133	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541017134	Walker A motif; other site
999541017135	ATP binding site [chemical binding]; other site
999541017136	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
999541017137	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
999541017138	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
999541017139	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
999541017140	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
999541017141	ATP binding site [chemical binding]; other site
999541017142	Walker A motif; other site
999541017143	hexamer interface [polypeptide binding]; other site
999541017144	Walker B motif; other site
999541017145	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
999541017146	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
999541017147	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541017148	Walker A motif; other site
999541017149	ATP binding site [chemical binding]; other site
999541017150	Walker B motif; other site
999541017151	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
999541017152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017153	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541017154	dimerization interface [polypeptide binding]; other site
999541017155	substrate binding pocket [chemical binding]; other site
999541017156	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
999541017157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541017158	putative substrate translocation pore; other site
999541017159	Pirin-related protein [General function prediction only]; Region: COG1741
999541017160	Pirin; Region: Pirin; pfam02678
999541017161	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
999541017162	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541017163	oxidoreductase; Provisional; Region: PRK06196
999541017164	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
999541017165	putative NAD(P) binding site [chemical binding]; other site
999541017166	active site
999541017167	Integrase core domain; Region: rve; pfam00665
999541017168	Integrase core domain; Region: rve_3; cl15866
999541017169	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541017170	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541017171	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
999541017172	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
999541017173	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
999541017174	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
999541017175	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
999541017176	ParA-like protein; Provisional; Region: PHA02518
999541017177	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541017178	P-loop; other site
999541017179	Magnesium ion binding site [ion binding]; other site
999541017180	Replication initiator protein A; Region: RPA; pfam10134
999541017181	Helix-turn-helix domain; Region: HTH_17; pfam12728
999541017182	Uncharacterized conserved protein [Function unknown]; Region: COG5419
999541017183	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
999541017184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541017185	non-specific DNA binding site [nucleotide binding]; other site
999541017186	salt bridge; other site
999541017187	sequence-specific DNA binding site [nucleotide binding]; other site
999541017188	Uncharacterized conserved protein [Function unknown]; Region: COG5489
999541017189	ParB-like nuclease domain; Region: ParBc; pfam02195
999541017190	Domain of unknown function (DUF932); Region: DUF932; pfam06067
999541017191	TIR domain; Region: TIR_2; pfam13676
999541017192	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
999541017193	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
999541017194	SIR2-like domain; Region: SIR2_2; pfam13289
999541017195	TIR domain; Region: TIR_2; pfam13676
999541017196	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
999541017197	putative uracil binding site [chemical binding]; other site
999541017198	putative active site [active]
999541017199	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
999541017200	putative metal binding site [ion binding]; other site
999541017201	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
999541017202	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
999541017203	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
999541017204	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
999541017205	integrase; Provisional; Region: PRK09692
999541017206	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
999541017207	active site
999541017208	Int/Topo IB signature motif; other site
999541017209	GMP synthase; Reviewed; Region: guaA; PRK00074
999541017210	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
999541017211	AMP/PPi binding site [chemical binding]; other site
999541017212	candidate oxyanion hole; other site
999541017213	catalytic triad [active]
999541017214	potential glutamine specificity residues [chemical binding]; other site
999541017215	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
999541017216	ATP Binding subdomain [chemical binding]; other site
999541017217	Ligand Binding sites [chemical binding]; other site
999541017218	Dimerization subdomain; other site
999541017219	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
999541017220	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
999541017221	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
999541017222	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
999541017223	active site
999541017224	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541017225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
999541017226	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
999541017227	putative coenzyme Q binding site [chemical binding]; other site
999541017228	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
999541017229	SmpB-tmRNA interface; other site
999541017230	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
999541017231	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
999541017232	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
999541017233	phosphoenolpyruvate synthase; Validated; Region: PRK06464
999541017234	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
999541017235	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
999541017236	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
999541017237	PEP synthetase regulatory protein; Provisional; Region: PRK05339
999541017238	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
999541017239	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
999541017240	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
999541017241	RNA/DNA hybrid binding site [nucleotide binding]; other site
999541017242	active site
999541017243	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
999541017244	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
999541017245	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
999541017246	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
999541017247	active site
999541017248	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
999541017249	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
999541017250	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
999541017251	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
999541017252	trimer interface [polypeptide binding]; other site
999541017253	active site
999541017254	UDP-GlcNAc binding site [chemical binding]; other site
999541017255	lipid binding site [chemical binding]; lipid-binding site
999541017256	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
999541017257	periplasmic chaperone; Provisional; Region: PRK10780
999541017258	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
999541017259	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541017260	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541017261	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541017262	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541017263	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
999541017264	Surface antigen; Region: Bac_surface_Ag; pfam01103
999541017265	zinc metallopeptidase RseP; Provisional; Region: PRK10779
999541017266	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
999541017267	active site
999541017268	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
999541017269	protein binding site [polypeptide binding]; other site
999541017270	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
999541017271	putative substrate binding region [chemical binding]; other site
999541017272	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
999541017273	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
999541017274	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
999541017275	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
999541017276	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
999541017277	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
999541017278	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
999541017279	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
999541017280	catalytic residue [active]
999541017281	putative FPP diphosphate  binding site; other site
999541017282	putative FPP binding hydrophobic cleft; other site
999541017283	dimer interface [polypeptide binding]; other site
999541017284	putative IPP diphosphate binding site; other site
999541017285	ribosome recycling factor; Reviewed; Region: frr; PRK00083
999541017286	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
999541017287	hinge region; other site
999541017288	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
999541017289	putative nucleotide binding site [chemical binding]; other site
999541017290	uridine monophosphate binding site [chemical binding]; other site
999541017291	homohexameric interface [polypeptide binding]; other site
999541017292	elongation factor Ts; Provisional; Region: tsf; PRK09377
999541017293	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
999541017294	Elongation factor TS; Region: EF_TS; pfam00889
999541017295	Elongation factor TS; Region: EF_TS; pfam00889
999541017296	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
999541017297	rRNA interaction site [nucleotide binding]; other site
999541017298	S8 interaction site; other site
999541017299	putative laminin-1 binding site; other site
999541017300	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
999541017301	active site
999541017302	PII uridylyl-transferase; Provisional; Region: PRK03059
999541017303	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
999541017304	metal binding triad; other site
999541017305	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
999541017306	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541017307	Zn2+ binding site [ion binding]; other site
999541017308	Mg2+ binding site [ion binding]; other site
999541017309	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
999541017310	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
999541017311	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
999541017312	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541017313	RNA binding surface [nucleotide binding]; other site
999541017314	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
999541017315	active site
999541017316	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
999541017317	active site
999541017318	catalytic residues [active]
999541017319	metal binding site [ion binding]; metal-binding site
999541017320	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
999541017321	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
999541017322	nucleotide binding pocket [chemical binding]; other site
999541017323	K-X-D-G motif; other site
999541017324	catalytic site [active]
999541017325	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
999541017326	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
999541017327	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
999541017328	BRCT sequence motif; other site
999541017329	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
999541017330	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
999541017331	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
999541017332	Walker A/P-loop; other site
999541017333	ATP binding site [chemical binding]; other site
999541017334	Q-loop/lid; other site
999541017335	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
999541017336	Q-loop/lid; other site
999541017337	ABC transporter signature motif; other site
999541017338	Walker B; other site
999541017339	D-loop; other site
999541017340	H-loop/switch region; other site
999541017341	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541017342	EamA-like transporter family; Region: EamA; pfam00892
999541017343	EamA-like transporter family; Region: EamA; pfam00892
999541017344	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
999541017345	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541017346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541017347	homodimer interface [polypeptide binding]; other site
999541017348	catalytic residue [active]
999541017349	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
999541017350	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
999541017351	trimer interface [polypeptide binding]; other site
999541017352	active site
999541017353	substrate binding site [chemical binding]; other site
999541017354	CoA binding site [chemical binding]; other site
999541017355	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
999541017356	ArsC family; Region: ArsC; pfam03960
999541017357	putative catalytic residues [active]
999541017358	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
999541017359	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
999541017360	metal binding site [ion binding]; metal-binding site
999541017361	dimer interface [polypeptide binding]; other site
999541017362	HemK family putative methylases; Region: hemK_fam; TIGR00536
999541017363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541017364	S-adenosylmethionine binding site [chemical binding]; other site
999541017365	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
999541017366	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
999541017367	putative active site [active]
999541017368	catalytic site [active]
999541017369	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
999541017370	putative active site [active]
999541017371	catalytic site [active]
999541017372	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
999541017373	catalytic residues [active]
999541017374	dimer interface [polypeptide binding]; other site
999541017375	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
999541017376	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541017377	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541017378	ABC transporter; Region: ABC_tran_2; pfam12848
999541017379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541017380	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
999541017381	DNA repair protein RadA; Provisional; Region: PRK11823
999541017382	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
999541017383	Walker A motif/ATP binding site; other site
999541017384	ATP binding site [chemical binding]; other site
999541017385	Walker B motif; other site
999541017386	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
999541017387	alanine racemase; Reviewed; Region: dadX; PRK03646
999541017388	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
999541017389	active site
999541017390	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541017391	substrate binding site [chemical binding]; other site
999541017392	catalytic residues [active]
999541017393	dimer interface [polypeptide binding]; other site
999541017394	lysophospholipid transporter LplT; Provisional; Region: PRK11195
999541017395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541017396	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
999541017397	dimer interface [polypeptide binding]; other site
999541017398	substrate binding site [chemical binding]; other site
999541017399	ATP binding site [chemical binding]; other site
999541017400	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
999541017401	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
999541017402	Fe-S cluster binding site [ion binding]; other site
999541017403	active site
999541017404	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
999541017405	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017406	Coenzyme A binding pocket [chemical binding]; other site
999541017407	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
999541017408	Glycoprotease family; Region: Peptidase_M22; pfam00814
999541017409	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
999541017410	acyl-CoA binding pocket [chemical binding]; other site
999541017411	CoA binding site [chemical binding]; other site
999541017412	helicase 45; Provisional; Region: PTZ00424
999541017413	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
999541017414	ATP binding site [chemical binding]; other site
999541017415	Mg++ binding site [ion binding]; other site
999541017416	motif III; other site
999541017417	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541017418	nucleotide binding region [chemical binding]; other site
999541017419	ATP-binding site [chemical binding]; other site
999541017420	isocitrate lyase; Provisional; Region: PRK15063
999541017421	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
999541017422	tetramer interface [polypeptide binding]; other site
999541017423	active site
999541017424	Mg2+/Mn2+ binding site [ion binding]; other site
999541017425	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
999541017426	Ligand Binding Site [chemical binding]; other site
999541017427	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017428	transcriptional activator TtdR; Provisional; Region: PRK09801
999541017429	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541017430	putative effector binding pocket; other site
999541017431	dimerization interface [polypeptide binding]; other site
999541017432	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
999541017433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541017434	motif II; other site
999541017435	malate synthase A; Region: malate_syn_A; TIGR01344
999541017436	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
999541017437	active site
999541017438	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
999541017439	putative active site pocket [active]
999541017440	dimerization interface [polypeptide binding]; other site
999541017441	putative catalytic residue [active]
999541017442	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541017443	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
999541017444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017446	Coenzyme A binding pocket [chemical binding]; other site
999541017447	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
999541017448	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
999541017449	active site
999541017450	HIGH motif; other site
999541017451	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
999541017452	active site
999541017453	KMSKS motif; other site
999541017454	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541017455	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
999541017456	active site
999541017457	nucleophile elbow; other site
999541017458	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
999541017459	NlpC/P60 family; Region: NLPC_P60; pfam00877
999541017460	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
999541017461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541017462	Walker A/P-loop; other site
999541017463	ATP binding site [chemical binding]; other site
999541017464	Q-loop/lid; other site
999541017465	ABC transporter signature motif; other site
999541017466	Walker B; other site
999541017467	D-loop; other site
999541017468	H-loop/switch region; other site
999541017469	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541017470	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541017471	Walker A/P-loop; other site
999541017472	ATP binding site [chemical binding]; other site
999541017473	Q-loop/lid; other site
999541017474	ABC transporter signature motif; other site
999541017475	Walker B; other site
999541017476	D-loop; other site
999541017477	H-loop/switch region; other site
999541017478	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541017479	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
999541017480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541017481	dimer interface [polypeptide binding]; other site
999541017482	conserved gate region; other site
999541017483	putative PBP binding loops; other site
999541017484	ABC-ATPase subunit interface; other site
999541017485	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
999541017486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541017487	dimer interface [polypeptide binding]; other site
999541017488	conserved gate region; other site
999541017489	putative PBP binding loops; other site
999541017490	ABC-ATPase subunit interface; other site
999541017491	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
999541017492	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
999541017493	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
999541017494	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541017495	substrate binding site [chemical binding]; other site
999541017496	ATP binding site [chemical binding]; other site
999541017497	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541017498	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541017499	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
999541017500	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
999541017501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541017502	DNA-binding site [nucleotide binding]; DNA binding site
999541017503	UTRA domain; Region: UTRA; pfam07702
999541017504	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541017505	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541017506	trimer interface [polypeptide binding]; other site
999541017507	eyelet of channel; other site
999541017508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017509	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541017510	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
999541017511	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541017512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017513	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541017514	dimerization interface [polypeptide binding]; other site
999541017515	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
999541017516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541017517	putative substrate translocation pore; other site
999541017518	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541017519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541017520	active site
999541017521	dimerization interface [polypeptide binding]; other site
999541017522	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541017523	DNA binding residues [nucleotide binding]
999541017524	dimerization interface [polypeptide binding]; other site
999541017525	Fumarase C-terminus; Region: Fumerase_C; cl00795
999541017526	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
999541017527	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
999541017528	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541017529	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541017530	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
999541017531	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541017532	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541017533	active site
999541017534	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541017535	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541017536	trimer interface [polypeptide binding]; other site
999541017537	eyelet of channel; other site
999541017538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541017539	D-galactonate transporter; Region: 2A0114; TIGR00893
999541017540	putative substrate translocation pore; other site
999541017541	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
999541017542	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
999541017543	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541017544	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541017545	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
999541017546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541017547	NAD(P) binding site [chemical binding]; other site
999541017548	active site
999541017549	Cache domain; Region: Cache_1; pfam02743
999541017550	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541017551	dimerization interface [polypeptide binding]; other site
999541017552	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541017553	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541017554	dimer interface [polypeptide binding]; other site
999541017555	putative CheW interface [polypeptide binding]; other site
999541017556	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
999541017557	active site
999541017558	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
999541017559	FAD binding pocket [chemical binding]; other site
999541017560	conserved FAD binding motif [chemical binding]; other site
999541017561	phosphate binding motif [ion binding]; other site
999541017562	beta-alpha-beta structure motif; other site
999541017563	NAD binding pocket [chemical binding]; other site
999541017564	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541017565	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
999541017566	catalytic loop [active]
999541017567	iron binding site [ion binding]; other site
999541017568	Uncharacterized conserved protein [Function unknown]; Region: COG3268
999541017569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541017570	NAD(P) binding site [chemical binding]; other site
999541017571	citrate-proton symporter; Provisional; Region: PRK15075
999541017572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541017573	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
999541017574	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
999541017575	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541017576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017577	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541017578	dimerization interface [polypeptide binding]; other site
999541017579	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
999541017580	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541017581	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017582	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541017583	active site
999541017584	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541017585	catalytic tetrad [active]
999541017586	aspartate kinase; Reviewed; Region: PRK06635
999541017587	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
999541017588	putative nucleotide binding site [chemical binding]; other site
999541017589	putative catalytic residues [active]
999541017590	putative Mg ion binding site [ion binding]; other site
999541017591	putative aspartate binding site [chemical binding]; other site
999541017592	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
999541017593	putative allosteric regulatory site; other site
999541017594	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
999541017595	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
999541017596	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
999541017597	Ligand Binding Site [chemical binding]; other site
999541017598	TilS substrate binding domain; Region: TilS; pfam09179
999541017599	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
999541017600	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
999541017601	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
999541017602	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
999541017603	endonuclease III; Region: ENDO3c; smart00478
999541017604	minor groove reading motif; other site
999541017605	helix-hairpin-helix signature motif; other site
999541017606	substrate binding pocket [chemical binding]; other site
999541017607	active site
999541017608	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
999541017609	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
999541017610	active site
999541017611	HIGH motif; other site
999541017612	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
999541017613	KMSKS motif; other site
999541017614	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
999541017615	tRNA binding surface [nucleotide binding]; other site
999541017616	anticodon binding site; other site
999541017617	TPR repeat; Region: TPR_11; pfam13414
999541017618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541017619	binding surface
999541017620	TPR motif; other site
999541017621	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
999541017622	substrate binding site [chemical binding]; other site
999541017623	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
999541017624	substrate binding site [chemical binding]; other site
999541017625	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
999541017626	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
999541017627	putative active site [active]
999541017628	putative metal binding site [ion binding]; other site
999541017629	serine O-acetyltransferase; Region: cysE; TIGR01172
999541017630	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
999541017631	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
999541017632	trimer interface [polypeptide binding]; other site
999541017633	active site
999541017634	substrate binding site [chemical binding]; other site
999541017635	CoA binding site [chemical binding]; other site
999541017636	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
999541017637	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
999541017638	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
999541017639	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
999541017640	active site
999541017641	dimerization interface [polypeptide binding]; other site
999541017642	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
999541017643	Amidase; Region: Amidase; cl11426
999541017644	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
999541017645	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
999541017646	putative ligand binding site [chemical binding]; other site
999541017647	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
999541017648	TM-ABC transporter signature motif; other site
999541017649	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541017650	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
999541017651	TM-ABC transporter signature motif; other site
999541017652	Isochorismatase family; Region: Isochorismatase; pfam00857
999541017653	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
999541017654	catalytic triad [active]
999541017655	conserved cis-peptide bond; other site
999541017656	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
999541017657	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541017658	Walker A/P-loop; other site
999541017659	ATP binding site [chemical binding]; other site
999541017660	Q-loop/lid; other site
999541017661	ABC transporter signature motif; other site
999541017662	Walker B; other site
999541017663	D-loop; other site
999541017664	H-loop/switch region; other site
999541017665	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541017666	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
999541017667	Isochorismatase family; Region: Isochorismatase; pfam00857
999541017668	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
999541017669	catalytic triad [active]
999541017670	conserved cis-peptide bond; other site
999541017671	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
999541017672	SnoaL-like domain; Region: SnoaL_3; pfam13474
999541017673	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541017674	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541017675	DNA-binding site [nucleotide binding]; DNA binding site
999541017676	FCD domain; Region: FCD; pfam07729
999541017677	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
999541017678	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
999541017679	2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812
999541017680	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
999541017681	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
999541017682	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
999541017683	NADP binding site [chemical binding]; other site
999541017684	homodimer interface [polypeptide binding]; other site
999541017685	active site
999541017686	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
999541017687	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541017688	dimerization interface [polypeptide binding]; other site
999541017689	putative Zn2+ binding site [ion binding]; other site
999541017690	putative DNA binding site [nucleotide binding]; other site
999541017691	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541017692	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541017693	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017694	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541017695	dimerization interface [polypeptide binding]; other site
999541017696	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541017697	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541017698	Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642
999541017699	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541017700	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
999541017701	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
999541017702	multimer interface [polypeptide binding]; other site
999541017703	active site
999541017704	catalytic triad [active]
999541017705	dimer interface [polypeptide binding]; other site
999541017706	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
999541017707	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
999541017708	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
999541017709	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541017710	Walker A/P-loop; other site
999541017711	ATP binding site [chemical binding]; other site
999541017712	Q-loop/lid; other site
999541017713	ABC transporter signature motif; other site
999541017714	Walker B; other site
999541017715	D-loop; other site
999541017716	H-loop/switch region; other site
999541017717	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
999541017718	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541017719	Walker A/P-loop; other site
999541017720	ATP binding site [chemical binding]; other site
999541017721	Q-loop/lid; other site
999541017722	ABC transporter signature motif; other site
999541017723	Walker B; other site
999541017724	D-loop; other site
999541017725	H-loop/switch region; other site
999541017726	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541017727	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541017728	TM-ABC transporter signature motif; other site
999541017729	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541017730	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541017731	TM-ABC transporter signature motif; other site
999541017732	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
999541017733	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
999541017734	putative ligand binding site [chemical binding]; other site
999541017735	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
999541017736	Na binding site [ion binding]; other site
999541017737	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541017738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541017739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541017740	dimer interface [polypeptide binding]; other site
999541017741	phosphorylation site [posttranslational modification]
999541017742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541017743	ATP binding site [chemical binding]; other site
999541017744	Mg2+ binding site [ion binding]; other site
999541017745	G-X-G motif; other site
999541017746	Response regulator receiver domain; Region: Response_reg; pfam00072
999541017747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541017748	active site
999541017749	phosphorylation site [posttranslational modification]
999541017750	intermolecular recognition site; other site
999541017751	dimerization interface [polypeptide binding]; other site
999541017752	Response regulator receiver domain; Region: Response_reg; pfam00072
999541017753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541017754	active site
999541017755	phosphorylation site [posttranslational modification]
999541017756	intermolecular recognition site; other site
999541017757	dimerization interface [polypeptide binding]; other site
999541017758	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541017759	DNA binding residues [nucleotide binding]
999541017760	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
999541017761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541017762	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
999541017763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541017764	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541017765	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017766	Coenzyme A binding pocket [chemical binding]; other site
999541017767	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541017768	dimerization interface [polypeptide binding]; other site
999541017769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017770	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
999541017771	Coenzyme A binding pocket [chemical binding]; other site
999541017772	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541017773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541017774	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
999541017775	putative substrate binding pocket [chemical binding]; other site
999541017776	dimerization interface [polypeptide binding]; other site
999541017777	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664
999541017778	putative active site [active]
999541017779	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
999541017780	carboxyltransferase (CT) interaction site; other site
999541017781	biotinylation site [posttranslational modification]; other site
999541017782	acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833
999541017783	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
999541017784	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541017785	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
999541017786	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
999541017787	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
999541017788	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
999541017789	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541017790	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
999541017791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541017792	Coenzyme A binding pocket [chemical binding]; other site
999541017793	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
999541017794	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541017795	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
999541017796	hypothetical protein; Provisional; Region: PRK10316
999541017797	YfdX protein; Region: YfdX; pfam10938
999541017798	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541017799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017800	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541017801	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
999541017802	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541017803	putative C-terminal domain interface [polypeptide binding]; other site
999541017804	putative GSH binding site (G-site) [chemical binding]; other site
999541017805	putative dimer interface [polypeptide binding]; other site
999541017806	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541017807	N-terminal domain interface [polypeptide binding]; other site
999541017808	dimer interface [polypeptide binding]; other site
999541017809	substrate binding pocket (H-site) [chemical binding]; other site
999541017810	Cupin; Region: Cupin_6; pfam12852
999541017811	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017812	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541017813	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541017814	PAS domain; Region: PAS; smart00091
999541017815	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
999541017816	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541017817	NAD(P) binding site [chemical binding]; other site
999541017818	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541017819	NAD(P) binding site [chemical binding]; other site
999541017820	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
999541017821	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
999541017822	ATP binding site [chemical binding]; other site
999541017823	dimerization interface [polypeptide binding]; other site
999541017824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541017825	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
999541017826	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
999541017827	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
999541017828	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
999541017829	Phage Tail Protein X; Region: Phage_tail_X; cl02088
999541017830	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
999541017831	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
999541017832	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
999541017833	Phage tail tube protein FII; Region: Phage_tube; pfam04985
999541017834	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
999541017835	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
999541017836	Phage Tail Collar Domain; Region: Collar; pfam07484
999541017837	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
999541017838	Baseplate J-like protein; Region: Baseplate_J; cl01294
999541017839	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
999541017840	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
999541017841	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
999541017842	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
999541017843	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
999541017844	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
999541017845	Clp protease; Region: CLP_protease; pfam00574
999541017846	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
999541017847	oligomer interface [polypeptide binding]; other site
999541017848	active site residues [active]
999541017849	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
999541017850	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
999541017851	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
999541017852	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
999541017853	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
999541017854	Zn binding sites [ion binding]; other site
999541017855	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
999541017856	Virulence-associated protein E; Region: VirE; pfam05272
999541017857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541017858	sequence-specific DNA binding site [nucleotide binding]; other site
999541017859	salt bridge; other site
999541017860	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
999541017861	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
999541017862	MutS domain I; Region: MutS_I; pfam01624
999541017863	MutS domain III; Region: MutS_III; pfam05192
999541017864	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
999541017865	Walker A/P-loop; other site
999541017866	ATP binding site [chemical binding]; other site
999541017867	Q-loop/lid; other site
999541017868	ABC transporter signature motif; other site
999541017869	Walker B; other site
999541017870	D-loop; other site
999541017871	H-loop/switch region; other site
999541017872	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
999541017873	Uncharacterized conserved protein [Function unknown]; Region: COG2850
999541017874	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
999541017875	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
999541017876	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
999541017877	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
999541017878	dihydrodipicolinate synthase; Region: dapA; TIGR00674
999541017879	dimer interface [polypeptide binding]; other site
999541017880	active site
999541017881	catalytic residue [active]
999541017882	Methyltransferase domain; Region: Methyltransf_18; pfam12847
999541017883	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
999541017884	active site
999541017885	HIGH motif; other site
999541017886	dimer interface [polypeptide binding]; other site
999541017887	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541017888	active site
999541017889	KMSKS motif; other site
999541017890	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
999541017891	Peptidase family M50; Region: Peptidase_M50; pfam02163
999541017892	active site
999541017893	putative substrate binding region [chemical binding]; other site
999541017894	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
999541017895	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
999541017896	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
999541017897	active site
999541017898	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
999541017899	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541017900	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541017901	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
999541017902	catalytic site [active]
999541017903	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541017904	dinuclear metal binding motif [ion binding]; other site
999541017905	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
999541017906	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
999541017907	trimer interface [polypeptide binding]; other site
999541017908	putative metal binding site [ion binding]; other site
999541017909	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
999541017910	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
999541017911	dimerization interface [polypeptide binding]; other site
999541017912	domain crossover interface; other site
999541017913	redox-dependent activation switch; other site
999541017914	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
999541017915	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
999541017916	enolase; Provisional; Region: eno; PRK00077
999541017917	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
999541017918	dimer interface [polypeptide binding]; other site
999541017919	metal binding site [ion binding]; metal-binding site
999541017920	substrate binding pocket [chemical binding]; other site
999541017921	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
999541017922	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
999541017923	CTP synthetase; Validated; Region: pyrG; PRK05380
999541017924	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
999541017925	Catalytic site [active]
999541017926	active site
999541017927	UTP binding site [chemical binding]; other site
999541017928	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
999541017929	active site
999541017930	putative oxyanion hole; other site
999541017931	catalytic triad [active]
999541017932	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541017933	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
999541017934	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
999541017935	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
999541017936	Competence protein; Region: Competence; pfam03772
999541017937	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
999541017938	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
999541017939	active site
999541017940	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
999541017941	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
999541017942	Walker A/P-loop; other site
999541017943	ATP binding site [chemical binding]; other site
999541017944	Q-loop/lid; other site
999541017945	ABC transporter signature motif; other site
999541017946	Walker B; other site
999541017947	D-loop; other site
999541017948	H-loop/switch region; other site
999541017949	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
999541017950	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
999541017951	FtsX-like permease family; Region: FtsX; pfam02687
999541017952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
999541017953	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
999541017954	DHH family; Region: DHH; pfam01368
999541017955	DHHA1 domain; Region: DHHA1; pfam02272
999541017956	This domain is found in peptide chain release factors; Region: PCRF; smart00937
999541017957	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
999541017958	RF-1 domain; Region: RF-1; pfam00472
999541017959	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
999541017960	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
999541017961	dimer interface [polypeptide binding]; other site
999541017962	putative anticodon binding site; other site
999541017963	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
999541017964	motif 1; other site
999541017965	active site
999541017966	motif 2; other site
999541017967	motif 3; other site
999541017968	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
999541017969	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
999541017970	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541017971	catalytic loop [active]
999541017972	iron binding site [ion binding]; other site
999541017973	chaperone protein HscA; Provisional; Region: hscA; PRK05183
999541017974	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
999541017975	nucleotide binding site [chemical binding]; other site
999541017976	putative NEF/HSP70 interaction site [polypeptide binding]; other site
999541017977	SBD interface [polypeptide binding]; other site
999541017978	co-chaperone HscB; Provisional; Region: hscB; PRK03578
999541017979	DnaJ domain; Region: DnaJ; pfam00226
999541017980	HSP70 interaction site [polypeptide binding]; other site
999541017981	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
999541017982	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
999541017983	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
999541017984	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
999541017985	trimerization site [polypeptide binding]; other site
999541017986	active site
999541017987	cysteine desulfurase; Provisional; Region: PRK14012
999541017988	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
999541017989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541017990	catalytic residue [active]
999541017991	Predicted transcriptional regulator [Transcription]; Region: COG1959
999541017992	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
999541017993	Low molecular weight phosphatase family; Region: LMWPc; cd00115
999541017994	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
999541017995	active site
999541017996	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
999541017997	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
999541017998	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
999541017999	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
999541018000	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
999541018001	Cysteine-rich domain; Region: CCG; pfam02754
999541018002	Cysteine-rich domain; Region: CCG; pfam02754
999541018003	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541018004	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541018005	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541018006	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
999541018007	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
999541018008	Phasin protein; Region: Phasin_2; pfam09361
999541018009	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541018010	E3 interaction surface; other site
999541018011	lipoyl attachment site [posttranslational modification]; other site
999541018012	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
999541018013	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
999541018014	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541018015	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
999541018016	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
999541018017	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541018018	E3 interaction surface; other site
999541018019	lipoyl attachment site [posttranslational modification]; other site
999541018020	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541018021	E3 interaction surface; other site
999541018022	lipoyl attachment site [posttranslational modification]; other site
999541018023	e3 binding domain; Region: E3_binding; pfam02817
999541018024	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
999541018025	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
999541018026	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
999541018027	dimer interface [polypeptide binding]; other site
999541018028	TPP-binding site [chemical binding]; other site
999541018029	PAS domain S-box; Region: sensory_box; TIGR00229
999541018030	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
999541018031	putative active site [active]
999541018032	heme pocket [chemical binding]; other site
999541018033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541018034	dimer interface [polypeptide binding]; other site
999541018035	phosphorylation site [posttranslational modification]
999541018036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018037	ATP binding site [chemical binding]; other site
999541018038	Mg2+ binding site [ion binding]; other site
999541018039	G-X-G motif; other site
999541018040	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
999541018041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541018042	active site
999541018043	phosphorylation site [posttranslational modification]
999541018044	intermolecular recognition site; other site
999541018045	dimerization interface [polypeptide binding]; other site
999541018046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541018047	DNA binding residues [nucleotide binding]
999541018048	dimerization interface [polypeptide binding]; other site
999541018049	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
999541018050	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
999541018051	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
999541018052	homodimer interface [polypeptide binding]; other site
999541018053	NADP binding site [chemical binding]; other site
999541018054	substrate binding site [chemical binding]; other site
999541018055	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
999541018056	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
999541018057	active site
999541018058	Zn binding site [ion binding]; other site
999541018059	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
999541018060	active site
999541018061	DNA polymerase IV; Validated; Region: PRK02406
999541018062	DNA binding site [nucleotide binding]
999541018063	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541018064	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
999541018065	aspartate racemase; Region: asp_race; TIGR00035
999541018066	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
999541018067	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
999541018068	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
999541018069	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
999541018070	Moco binding site; other site
999541018071	metal coordination site [ion binding]; other site
999541018072	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
999541018073	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
999541018074	RNA polymerase sigma factor; Provisional; Region: PRK12536
999541018075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541018076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541018077	DNA binding residues [nucleotide binding]
999541018078	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
999541018079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541018080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541018081	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
999541018082	homotrimer interaction site [polypeptide binding]; other site
999541018083	putative active site [active]
999541018084	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
999541018085	putative catalytic site [active]
999541018086	putative phosphate binding site [ion binding]; other site
999541018087	active site
999541018088	metal binding site A [ion binding]; metal-binding site
999541018089	DNA binding site [nucleotide binding]
999541018090	putative AP binding site [nucleotide binding]; other site
999541018091	putative metal binding site B [ion binding]; other site
999541018092	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
999541018093	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541018094	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
999541018095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541018096	active site
999541018097	phosphorylation site [posttranslational modification]
999541018098	intermolecular recognition site; other site
999541018099	dimerization interface [polypeptide binding]; other site
999541018100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541018101	Walker A motif; other site
999541018102	ATP binding site [chemical binding]; other site
999541018103	Walker B motif; other site
999541018104	arginine finger; other site
999541018105	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541018106	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
999541018107	PAS domain; Region: PAS; smart00091
999541018108	putative active site [active]
999541018109	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541018110	dimer interface [polypeptide binding]; other site
999541018111	phosphorylation site [posttranslational modification]
999541018112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018113	ATP binding site [chemical binding]; other site
999541018114	Mg2+ binding site [ion binding]; other site
999541018115	G-X-G motif; other site
999541018116	glutamine synthetase; Provisional; Region: glnA; PRK09469
999541018117	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
999541018118	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
999541018119	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
999541018120	active site residue [active]
999541018121	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
999541018122	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
999541018123	putative MPT binding site; other site
999541018124	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
999541018125	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
999541018126	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
999541018127	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
999541018128	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
999541018129	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
999541018130	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
999541018131	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541018132	ATP binding site [chemical binding]; other site
999541018133	putative Mg++ binding site [ion binding]; other site
999541018134	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541018135	nucleotide binding region [chemical binding]; other site
999541018136	ATP-binding site [chemical binding]; other site
999541018137	Helicase associated domain (HA2); Region: HA2; pfam04408
999541018138	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
999541018139	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
999541018140	N-acetylglutamate synthase; Validated; Region: PRK05279
999541018141	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
999541018142	putative feedback inhibition sensing region; other site
999541018143	putative nucleotide binding site [chemical binding]; other site
999541018144	putative substrate binding site [chemical binding]; other site
999541018145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541018146	Coenzyme A binding pocket [chemical binding]; other site
999541018147	oxidative damage protection protein; Provisional; Region: PRK05408
999541018148	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
999541018149	putative aminotransferase; Validated; Region: PRK07480
999541018150	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541018151	inhibitor-cofactor binding pocket; inhibition site
999541018152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541018153	catalytic residue [active]
999541018154	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
999541018155	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
999541018156	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
999541018157	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
999541018158	catalytic triad [active]
999541018159	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
999541018160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541018161	non-specific DNA binding site [nucleotide binding]; other site
999541018162	salt bridge; other site
999541018163	sequence-specific DNA binding site [nucleotide binding]; other site
999541018164	Cupin domain; Region: Cupin_2; pfam07883
999541018165	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
999541018166	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
999541018167	NAD(P) binding site [chemical binding]; other site
999541018168	catalytic residues [active]
999541018169	N-formylglutamate amidohydrolase; Region: FGase; cl01522
999541018170	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
999541018171	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
999541018172	active site
999541018173	imidazolonepropionase; Validated; Region: PRK09356
999541018174	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
999541018175	active site
999541018176	HutD; Region: HutD; pfam05962
999541018177	urocanate hydratase; Provisional; Region: PRK05414
999541018178	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
999541018179	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541018180	DNA-binding site [nucleotide binding]; DNA binding site
999541018181	UTRA domain; Region: UTRA; pfam07702
999541018182	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
999541018183	active sites [active]
999541018184	tetramer interface [polypeptide binding]; other site
999541018185	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
999541018186	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
999541018187	DNA photolyase; Region: DNA_photolyase; pfam00875
999541018188	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
999541018189	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
999541018190	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541018191	Di-iron ligands [ion binding]; other site
999541018192	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541018193	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
999541018194	tetramerization interface [polypeptide binding]; other site
999541018195	NAD(P) binding site [chemical binding]; other site
999541018196	catalytic residues [active]
999541018197	mercuric reductase; Validated; Region: PRK06370
999541018198	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541018199	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
999541018200	Domain of unknown function DUF302; Region: DUF302; cl01364
999541018201	Cupin; Region: Cupin_6; pfam12852
999541018202	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541018203	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541018204	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541018205	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541018206	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541018207	catalytic residue [active]
999541018208	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
999541018209	HD domain; Region: HD_3; pfam13023
999541018210	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541018211	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541018212	non-specific DNA binding site [nucleotide binding]; other site
999541018213	salt bridge; other site
999541018214	sequence-specific DNA binding site [nucleotide binding]; other site
999541018215	PAAR motif; Region: PAAR_motif; pfam05488
999541018216	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
999541018217	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
999541018218	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
999541018219	acetyl-CoA synthetase; Provisional; Region: PRK00174
999541018220	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
999541018221	active site
999541018222	CoA binding site [chemical binding]; other site
999541018223	acyl-activating enzyme (AAE) consensus motif; other site
999541018224	AMP binding site [chemical binding]; other site
999541018225	acetate binding site [chemical binding]; other site
999541018226	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541018227	EamA-like transporter family; Region: EamA; pfam00892
999541018228	EamA-like transporter family; Region: EamA; pfam00892
999541018229	hypothetical protein; Provisional; Region: PRK05208
999541018230	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
999541018231	Fumarase C-terminus; Region: Fumerase_C; pfam05683
999541018232	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
999541018233	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
999541018234	heme binding site [chemical binding]; other site
999541018235	ferroxidase pore; other site
999541018236	ferroxidase diiron center [ion binding]; other site
999541018237	glutamate racemase; Provisional; Region: PRK00865
999541018238	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
999541018239	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
999541018240	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
999541018241	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
999541018242	TolR protein; Region: tolR; TIGR02801
999541018243	LysR family transcriptional regulator; Provisional; Region: PRK14997
999541018244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541018245	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
999541018246	putative effector binding pocket; other site
999541018247	putative dimerization interface [polypeptide binding]; other site
999541018248	Pirin-related protein [General function prediction only]; Region: COG1741
999541018249	Pirin; Region: Pirin; pfam02678
999541018250	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
999541018251	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
999541018252	putative hydrophobic ligand binding site [chemical binding]; other site
999541018253	Hemin uptake protein hemP; Region: hemP; pfam10636
999541018254	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
999541018255	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
999541018256	4Fe-4S binding domain; Region: Fer4_5; pfam12801
999541018257	Iron permease FTR1 family; Region: FTR1; cl00475
999541018258	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
999541018259	Fe2+ transport protein; Region: Iron_transport; pfam10634
999541018260	excinuclease ABC subunit B; Provisional; Region: PRK05298
999541018261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541018262	ATP binding site [chemical binding]; other site
999541018263	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541018264	nucleotide binding region [chemical binding]; other site
999541018265	ATP-binding site [chemical binding]; other site
999541018266	Ultra-violet resistance protein B; Region: UvrB; pfam12344
999541018267	UvrB/uvrC motif; Region: UVR; pfam02151
999541018268	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
999541018269	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541018270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541018271	homodimer interface [polypeptide binding]; other site
999541018272	catalytic residue [active]
999541018273	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
999541018274	classical (c) SDRs; Region: SDR_c; cd05233
999541018275	NAD(P) binding site [chemical binding]; other site
999541018276	active site
999541018277	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
999541018278	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541018279	active site
999541018280	catalytic tetrad [active]
999541018281	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
999541018282	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
999541018283	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
999541018284	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
999541018285	DNA binding residues [nucleotide binding]
999541018286	dimer interface [polypeptide binding]; other site
999541018287	copper binding site [ion binding]; other site
999541018288	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
999541018289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541018290	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
999541018291	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541018292	DNA binding residues [nucleotide binding]
999541018293	Predicted membrane protein [Function unknown]; Region: COG3235
999541018294	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
999541018295	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
999541018296	putative active site [active]
999541018297	Zn binding site [ion binding]; other site
999541018298	hypothetical protein; Validated; Region: PRK02101
999541018299	PIN domain; Region: PIN_3; pfam13470
999541018300	methionine aminotransferase; Validated; Region: PRK09082
999541018301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541018302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541018303	homodimer interface [polypeptide binding]; other site
999541018304	catalytic residue [active]
999541018305	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
999541018306	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
999541018307	C-terminal domain interface [polypeptide binding]; other site
999541018308	GSH binding site (G-site) [chemical binding]; other site
999541018309	dimer interface [polypeptide binding]; other site
999541018310	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
999541018311	N-terminal domain interface [polypeptide binding]; other site
999541018312	dimer interface [polypeptide binding]; other site
999541018313	substrate binding pocket (H-site) [chemical binding]; other site
999541018314	enoyl-CoA hydratase; Provisional; Region: PRK07511
999541018315	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541018316	substrate binding site [chemical binding]; other site
999541018317	oxyanion hole (OAH) forming residues; other site
999541018318	trimer interface [polypeptide binding]; other site
999541018319	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541018320	catalytic core [active]
999541018321	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
999541018322	putative active site [active]
999541018323	putative substrate binding site [chemical binding]; other site
999541018324	ATP binding site [chemical binding]; other site
999541018325	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541018326	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
999541018327	FAD binding site [chemical binding]; other site
999541018328	substrate binding site [chemical binding]; other site
999541018329	catalytic base [active]
999541018330	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
999541018331	putative active site [active]
999541018332	putative catalytic site [active]
999541018333	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
999541018334	putative active site [active]
999541018335	putative catalytic site [active]
999541018336	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
999541018337	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
999541018338	active site
999541018339	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
999541018340	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
999541018341	FAD binding site [chemical binding]; other site
999541018342	substrate binding site [chemical binding]; other site
999541018343	catalytic base [active]
999541018344	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
999541018345	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
999541018346	dimer interface [polypeptide binding]; other site
999541018347	ADP-ribose binding site [chemical binding]; other site
999541018348	active site
999541018349	nudix motif; other site
999541018350	metal binding site [ion binding]; metal-binding site
999541018351	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
999541018352	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
999541018353	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
999541018354	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
999541018355	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
999541018356	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
999541018357	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
999541018358	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
999541018359	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
999541018360	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
999541018361	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
999541018362	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
999541018363	4Fe-4S binding domain; Region: Fer4; pfam00037
999541018364	4Fe-4S binding domain; Region: Fer4; pfam00037
999541018365	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
999541018366	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
999541018367	NADH dehydrogenase subunit G; Validated; Region: PRK09129
999541018368	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541018369	catalytic loop [active]
999541018370	iron binding site [ion binding]; other site
999541018371	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
999541018372	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
999541018373	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
999541018374	SLBB domain; Region: SLBB; pfam10531
999541018375	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
999541018376	NADH dehydrogenase subunit E; Validated; Region: PRK07539
999541018377	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
999541018378	putative dimer interface [polypeptide binding]; other site
999541018379	[2Fe-2S] cluster binding site [ion binding]; other site
999541018380	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
999541018381	NADH dehydrogenase subunit D; Validated; Region: PRK06075
999541018382	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
999541018383	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
999541018384	NADH dehydrogenase subunit B; Validated; Region: PRK06411
999541018385	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
999541018386	Preprotein translocase SecG subunit; Region: SecG; pfam03840
999541018387	triosephosphate isomerase; Provisional; Region: PRK14567
999541018388	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
999541018389	substrate binding site [chemical binding]; other site
999541018390	dimer interface [polypeptide binding]; other site
999541018391	catalytic triad [active]
999541018392	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
999541018393	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
999541018394	NAD(P) binding site [chemical binding]; other site
999541018395	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
999541018396	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
999541018397	RNase E interface [polypeptide binding]; other site
999541018398	trimer interface [polypeptide binding]; other site
999541018399	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
999541018400	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
999541018401	RNase E interface [polypeptide binding]; other site
999541018402	trimer interface [polypeptide binding]; other site
999541018403	active site
999541018404	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
999541018405	putative nucleic acid binding region [nucleotide binding]; other site
999541018406	G-X-X-G motif; other site
999541018407	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
999541018408	RNA binding site [nucleotide binding]; other site
999541018409	domain interface; other site
999541018410	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
999541018411	16S/18S rRNA binding site [nucleotide binding]; other site
999541018412	S13e-L30e interaction site [polypeptide binding]; other site
999541018413	25S rRNA binding site [nucleotide binding]; other site
999541018414	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
999541018415	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
999541018416	putative ligand binding site [chemical binding]; other site
999541018417	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
999541018418	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
999541018419	active site clefts [active]
999541018420	zinc binding site [ion binding]; other site
999541018421	dimer interface [polypeptide binding]; other site
999541018422	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
999541018423	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
999541018424	Sulfate transporter family; Region: Sulfate_transp; pfam00916
999541018425	2-isopropylmalate synthase; Validated; Region: PRK00915
999541018426	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
999541018427	active site
999541018428	catalytic residues [active]
999541018429	metal binding site [ion binding]; metal-binding site
999541018430	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
999541018431	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
999541018432	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
999541018433	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
999541018434	ketol-acid reductoisomerase; Provisional; Region: PRK05479
999541018435	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
999541018436	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
999541018437	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
999541018438	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
999541018439	putative valine binding site [chemical binding]; other site
999541018440	dimer interface [polypeptide binding]; other site
999541018441	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
999541018442	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
999541018443	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
999541018444	PYR/PP interface [polypeptide binding]; other site
999541018445	dimer interface [polypeptide binding]; other site
999541018446	TPP binding site [chemical binding]; other site
999541018447	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
999541018448	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
999541018449	TPP-binding site [chemical binding]; other site
999541018450	dimer interface [polypeptide binding]; other site
999541018451	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541018452	RNA polymerase factor sigma-70; Validated; Region: PRK09047
999541018453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541018454	DNA binding residues [nucleotide binding]
999541018455	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
999541018456	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
999541018457	RDD family; Region: RDD; pfam06271
999541018458	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
999541018459	putative active site [active]
999541018460	putative metal binding site [ion binding]; other site
999541018461	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541018462	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
999541018463	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
999541018464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541018465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541018466	Bacterial transcriptional repressor; Region: TetR; pfam13972
999541018467	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
999541018468	glucose-1-dehydrogenase; Provisional; Region: PRK06947
999541018469	classical (c) SDRs; Region: SDR_c; cd05233
999541018470	NAD(P) binding site [chemical binding]; other site
999541018471	active site
999541018472	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
999541018473	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541018474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018475	putative substrate translocation pore; other site
999541018476	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
999541018477	apolar tunnel; other site
999541018478	heme binding site [chemical binding]; other site
999541018479	dimerization interface [polypeptide binding]; other site
999541018480	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
999541018481	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
999541018482	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
999541018483	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
999541018484	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
999541018485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541018486	active site
999541018487	phosphorylation site [posttranslational modification]
999541018488	intermolecular recognition site; other site
999541018489	dimerization interface [polypeptide binding]; other site
999541018490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541018491	DNA binding site [nucleotide binding]
999541018492	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
999541018493	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
999541018494	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
999541018495	Ligand Binding Site [chemical binding]; other site
999541018496	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
999541018497	GAF domain; Region: GAF_3; pfam13492
999541018498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541018499	dimer interface [polypeptide binding]; other site
999541018500	phosphorylation site [posttranslational modification]
999541018501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018502	ATP binding site [chemical binding]; other site
999541018503	Mg2+ binding site [ion binding]; other site
999541018504	G-X-G motif; other site
999541018505	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
999541018506	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
999541018507	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
999541018508	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
999541018509	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
999541018510	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
999541018511	NADP binding site [chemical binding]; other site
999541018512	dimer interface [polypeptide binding]; other site
999541018513	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
999541018514	active site
999541018515	dimer interfaces [polypeptide binding]; other site
999541018516	catalytic residues [active]
999541018517	short chain dehydrogenase; Provisional; Region: PRK08339
999541018518	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
999541018519	putative NAD(P) binding site [chemical binding]; other site
999541018520	putative active site [active]
999541018521	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541018522	active site
999541018523	hypothetical protein; Validated; Region: PRK00110
999541018524	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
999541018525	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
999541018526	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
999541018527	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
999541018528	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
999541018529	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
999541018530	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
999541018531	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
999541018532	active site
999541018533	(T/H)XGH motif; other site
999541018534	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
999541018535	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
999541018536	Maf-like protein; Region: Maf; pfam02545
999541018537	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
999541018538	active site
999541018539	dimer interface [polypeptide binding]; other site
999541018540	ribonuclease G; Provisional; Region: PRK11712
999541018541	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
999541018542	homodimer interface [polypeptide binding]; other site
999541018543	oligonucleotide binding site [chemical binding]; other site
999541018544	hypothetical protein; Validated; Region: PRK06201
999541018545	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
999541018546	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541018547	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541018548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018549	putative substrate translocation pore; other site
999541018550	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
999541018551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541018552	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541018553	dimerization interface [polypeptide binding]; other site
999541018554	substrate binding pocket [chemical binding]; other site
999541018555	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
999541018556	hypothetical protein; Validated; Region: PRK00068
999541018557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018558	putative substrate translocation pore; other site
999541018559	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541018560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541018561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541018562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541018563	dimerization interface [polypeptide binding]; other site
999541018564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018565	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541018566	putative substrate translocation pore; other site
999541018567	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
999541018568	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
999541018569	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541018570	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
999541018571	Walker A/P-loop; other site
999541018572	ATP binding site [chemical binding]; other site
999541018573	Q-loop/lid; other site
999541018574	ABC transporter signature motif; other site
999541018575	Walker B; other site
999541018576	D-loop; other site
999541018577	H-loop/switch region; other site
999541018578	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541018579	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
999541018580	putative metal binding site; other site
999541018581	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541018582	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541018583	active site
999541018584	O-Antigen ligase; Region: Wzy_C; pfam04932
999541018585	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
999541018586	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
999541018587	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541018588	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541018589	putative active site [active]
999541018590	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
999541018591	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
999541018592	putative active site [active]
999541018593	putative PHP Thumb interface [polypeptide binding]; other site
999541018594	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
999541018595	generic binding surface II; other site
999541018596	generic binding surface I; other site
999541018597	rhodanese superfamily protein; Provisional; Region: PRK05320
999541018598	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
999541018599	active site residue [active]
999541018600	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
999541018601	active site
999541018602	HIGH motif; other site
999541018603	nucleotide binding site [chemical binding]; other site
999541018604	active site
999541018605	KMSKS motif; other site
999541018606	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
999541018607	DEAD-like helicases superfamily; Region: DEXDc; smart00487
999541018608	ATP binding site [chemical binding]; other site
999541018609	Mg++ binding site [ion binding]; other site
999541018610	motif III; other site
999541018611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541018612	nucleotide binding region [chemical binding]; other site
999541018613	ATP-binding site [chemical binding]; other site
999541018614	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
999541018615	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
999541018616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541018617	ATP-grasp domain; Region: ATP-grasp; pfam02222
999541018618	META domain; Region: META; pfam03724
999541018619	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
999541018620	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
999541018621	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
999541018622	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
999541018623	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
999541018624	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
999541018625	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
999541018626	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
999541018627	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541018628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541018629	ferredoxin; Provisional; Region: PRK08764
999541018630	Putative Fe-S cluster; Region: FeS; pfam04060
999541018631	4Fe-4S binding domain; Region: Fer4; pfam00037
999541018632	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
999541018633	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
999541018634	minor groove reading motif; other site
999541018635	helix-hairpin-helix signature motif; other site
999541018636	substrate binding pocket [chemical binding]; other site
999541018637	active site
999541018638	EamA-like transporter family; Region: EamA; pfam00892
999541018639	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
999541018640	EamA-like transporter family; Region: EamA; cl17759
999541018641	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
999541018642	Cytochrome c; Region: Cytochrom_C; cl11414
999541018643	Cytochrome c553 [Energy production and conversion]; Region: COG2863
999541018644	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541018645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541018646	Walker A motif; other site
999541018647	ATP binding site [chemical binding]; other site
999541018648	Walker B motif; other site
999541018649	arginine finger; other site
999541018650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
999541018651	benzoate transporter; Region: benE; TIGR00843
999541018652	Benzoate membrane transport protein; Region: BenE; pfam03594
999541018653	transaldolase-like protein; Provisional; Region: PTZ00411
999541018654	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
999541018655	active site
999541018656	dimer interface [polypeptide binding]; other site
999541018657	catalytic residue [active]
999541018658	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
999541018659	dimer interface [polypeptide binding]; other site
999541018660	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541018661	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
999541018662	Na binding site [ion binding]; other site
999541018663	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
999541018664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541018665	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
999541018666	putative active site [active]
999541018667	Chorismate lyase; Region: Chor_lyase; cl01230
999541018668	heat shock protein 90; Provisional; Region: PRK05218
999541018669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018670	ATP binding site [chemical binding]; other site
999541018671	Mg2+ binding site [ion binding]; other site
999541018672	G-X-G motif; other site
999541018673	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
999541018674	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541018675	DNA-binding site [nucleotide binding]; DNA binding site
999541018676	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541018677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541018678	homodimer interface [polypeptide binding]; other site
999541018679	catalytic residue [active]
999541018680	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
999541018681	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
999541018682	EamA-like transporter family; Region: EamA; pfam00892
999541018683	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
999541018684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541018685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541018686	homodimer interface [polypeptide binding]; other site
999541018687	catalytic residue [active]
999541018688	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
999541018689	homotrimer interaction site [polypeptide binding]; other site
999541018690	putative active site [active]
999541018691	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
999541018692	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
999541018693	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541018694	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541018695	metal binding site [ion binding]; metal-binding site
999541018696	active site
999541018697	I-site; other site
999541018698	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541018699	Chromate transporter; Region: Chromate_transp; pfam02417
999541018700	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
999541018701	Chromate transporter; Region: Chromate_transp; pfam02417
999541018702	Predicted integral membrane protein [Function unknown]; Region: COG5615
999541018703	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
999541018704	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
999541018705	CAP-like domain; other site
999541018706	active site
999541018707	primary dimer interface [polypeptide binding]; other site
999541018708	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
999541018709	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
999541018710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018711	ATP binding site [chemical binding]; other site
999541018712	Mg2+ binding site [ion binding]; other site
999541018713	G-X-G motif; other site
999541018714	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
999541018715	anchoring element; other site
999541018716	dimer interface [polypeptide binding]; other site
999541018717	ATP binding site [chemical binding]; other site
999541018718	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
999541018719	active site
999541018720	metal binding site [ion binding]; metal-binding site
999541018721	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
999541018722	ABC transporter ATPase component; Reviewed; Region: PRK11147
999541018723	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
999541018724	Walker A/P-loop; other site
999541018725	ATP binding site [chemical binding]; other site
999541018726	Q-loop/lid; other site
999541018727	ABC transporter signature motif; other site
999541018728	Walker B; other site
999541018729	D-loop; other site
999541018730	H-loop/switch region; other site
999541018731	ABC transporter; Region: ABC_tran_2; pfam12848
999541018732	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541018733	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
999541018734	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
999541018735	Rubredoxin; Region: Rubredoxin; pfam00301
999541018736	iron binding site [ion binding]; other site
999541018737	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
999541018738	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
999541018739	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
999541018740	Ligand Binding Site [chemical binding]; other site
999541018741	Molecular Tunnel; other site
999541018742	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
999541018743	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
999541018744	Walker A/P-loop; other site
999541018745	ATP binding site [chemical binding]; other site
999541018746	Q-loop/lid; other site
999541018747	ABC transporter signature motif; other site
999541018748	Walker B; other site
999541018749	D-loop; other site
999541018750	H-loop/switch region; other site
999541018751	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
999541018752	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
999541018753	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
999541018754	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
999541018755	Phage Tail Protein X; Region: Phage_tail_X; cl02088
999541018756	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
999541018757	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
999541018758	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
999541018759	Phage tail tube protein FII; Region: Phage_tube; pfam04985
999541018760	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
999541018761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
999541018762	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541018763	sequence-specific DNA binding site [nucleotide binding]; other site
999541018764	salt bridge; other site
999541018765	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
999541018766	putative transposase OrfB; Reviewed; Region: PHA02517
999541018767	Integrase core domain; Region: rve; pfam00665
999541018768	Integrase core domain; Region: rve_3; pfam13683
999541018769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541018770	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
999541018771	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
999541018772	active site
999541018773	catalytic triad [active]
999541018774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541018775	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541018776	Walker A motif; other site
999541018777	ATP binding site [chemical binding]; other site
999541018778	Walker B motif; other site
999541018779	arginine finger; other site
999541018780	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
999541018781	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
999541018782	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541018783	active site
999541018784	DNA binding site [nucleotide binding]
999541018785	Int/Topo IB signature motif; other site
999541018786	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
999541018787	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
999541018788	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
999541018789	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
999541018790	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
999541018791	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178
999541018792	secondary substrate binding site; other site
999541018793	primary substrate binding site; other site
999541018794	inhibition loop; other site
999541018795	dimerization interface [polypeptide binding]; other site
999541018796	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
999541018797	substrate binding site [chemical binding]; other site
999541018798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018799	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541018800	putative substrate translocation pore; other site
999541018801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018802	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
999541018803	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
999541018804	active site
999541018805	homotetramer interface [polypeptide binding]; other site
999541018806	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541018807	MULE transposase domain; Region: MULE; pfam10551
999541018808	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541018809	MULE transposase domain; Region: MULE; pfam10551
999541018810	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541018811	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541018812	Walker A/P-loop; other site
999541018813	ATP binding site [chemical binding]; other site
999541018814	Q-loop/lid; other site
999541018815	ABC transporter signature motif; other site
999541018816	Walker B; other site
999541018817	D-loop; other site
999541018818	H-loop/switch region; other site
999541018819	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
999541018820	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
999541018821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541018822	dimer interface [polypeptide binding]; other site
999541018823	conserved gate region; other site
999541018824	putative PBP binding loops; other site
999541018825	ABC-ATPase subunit interface; other site
999541018826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541018827	dimer interface [polypeptide binding]; other site
999541018828	conserved gate region; other site
999541018829	putative PBP binding loops; other site
999541018830	ABC-ATPase subunit interface; other site
999541018831	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541018832	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541018833	dimerization interface [polypeptide binding]; other site
999541018834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541018835	dimer interface [polypeptide binding]; other site
999541018836	phosphorylation site [posttranslational modification]
999541018837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541018838	ATP binding site [chemical binding]; other site
999541018839	Mg2+ binding site [ion binding]; other site
999541018840	G-X-G motif; other site
999541018841	osmolarity response regulator; Provisional; Region: ompR; PRK09468
999541018842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541018843	active site
999541018844	phosphorylation site [posttranslational modification]
999541018845	intermolecular recognition site; other site
999541018846	dimerization interface [polypeptide binding]; other site
999541018847	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541018848	DNA binding site [nucleotide binding]
999541018849	Heavy-metal resistance; Region: Metal_resist; pfam13801
999541018850	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
999541018851	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541018852	substrate binding pocket [chemical binding]; other site
999541018853	membrane-bound complex binding site; other site
999541018854	hinge residues; other site
999541018855	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541018856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541018857	dimer interface [polypeptide binding]; other site
999541018858	conserved gate region; other site
999541018859	putative PBP binding loops; other site
999541018860	ABC-ATPase subunit interface; other site
999541018861	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
999541018862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541018863	dimer interface [polypeptide binding]; other site
999541018864	conserved gate region; other site
999541018865	putative PBP binding loops; other site
999541018866	ABC-ATPase subunit interface; other site
999541018867	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
999541018868	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541018869	Walker A/P-loop; other site
999541018870	ATP binding site [chemical binding]; other site
999541018871	Q-loop/lid; other site
999541018872	ABC transporter signature motif; other site
999541018873	Walker B; other site
999541018874	D-loop; other site
999541018875	H-loop/switch region; other site
999541018876	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541018877	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541018878	trimer interface [polypeptide binding]; other site
999541018879	eyelet of channel; other site
999541018880	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
999541018881	Nitrogen regulatory protein P-II; Region: P-II; smart00938
999541018882	NAD synthetase; Provisional; Region: PRK13981
999541018883	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
999541018884	multimer interface [polypeptide binding]; other site
999541018885	active site
999541018886	catalytic triad [active]
999541018887	protein interface 1 [polypeptide binding]; other site
999541018888	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
999541018889	homodimer interface [polypeptide binding]; other site
999541018890	NAD binding pocket [chemical binding]; other site
999541018891	ATP binding pocket [chemical binding]; other site
999541018892	Mg binding site [ion binding]; other site
999541018893	active-site loop [active]
999541018894	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
999541018895	Protein of unknown function, DUF482; Region: DUF482; pfam04339
999541018896	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
999541018897	GIY-YIG motif/motif A; other site
999541018898	putative active site [active]
999541018899	putative metal binding site [ion binding]; other site
999541018900	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
999541018901	dimer interface [polypeptide binding]; other site
999541018902	substrate binding site [chemical binding]; other site
999541018903	metal binding sites [ion binding]; metal-binding site
999541018904	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
999541018905	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
999541018906	NAD(P) binding site [chemical binding]; other site
999541018907	catalytic residues [active]
999541018908	catalytic residues [active]
999541018909	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
999541018910	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
999541018911	putative NAD(P) binding site [chemical binding]; other site
999541018912	active site
999541018913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541018914	D-galactonate transporter; Region: 2A0114; TIGR00893
999541018915	putative substrate translocation pore; other site
999541018916	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
999541018917	HemY protein N-terminus; Region: HemY_N; pfam07219
999541018918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
999541018919	TPR motif; other site
999541018920	binding surface
999541018921	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
999541018922	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
999541018923	active site
999541018924	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
999541018925	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
999541018926	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
999541018927	domain interfaces; other site
999541018928	active site
999541018929	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
999541018930	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
999541018931	Helix-turn-helix domain; Region: HTH_31; pfam13560
999541018932	argininosuccinate lyase; Provisional; Region: PRK00855
999541018933	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
999541018934	active sites [active]
999541018935	tetramer interface [polypeptide binding]; other site
999541018936	Predicted ATPase [General function prediction only]; Region: COG4637
999541018937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541018938	Walker A/P-loop; other site
999541018939	ATP binding site [chemical binding]; other site
999541018940	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
999541018941	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
999541018942	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
999541018943	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
999541018944	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
999541018945	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541018946	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541018947	catalytic residue [active]
999541018948	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
999541018949	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
999541018950	trimer interface [polypeptide binding]; other site
999541018951	active site
999541018952	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
999541018953	E-class dimer interface [polypeptide binding]; other site
999541018954	P-class dimer interface [polypeptide binding]; other site
999541018955	active site
999541018956	Cu2+ binding site [ion binding]; other site
999541018957	Zn2+ binding site [ion binding]; other site
999541018958	Domain of unknown function DUF59; Region: DUF59; pfam01883
999541018959	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
999541018960	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
999541018961	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541018962	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541018963	ligand binding site [chemical binding]; other site
999541018964	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
999541018965	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
999541018966	active site
999541018967	HIGH motif; other site
999541018968	KMSKS motif; other site
999541018969	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
999541018970	anticodon binding site; other site
999541018971	tRNA binding surface [nucleotide binding]; other site
999541018972	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
999541018973	dimer interface [polypeptide binding]; other site
999541018974	putative tRNA-binding site [nucleotide binding]; other site
999541018975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
999541018976	Family of unknown function (DUF490); Region: DUF490; pfam04357
999541018977	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
999541018978	Surface antigen; Region: Bac_surface_Ag; pfam01103
999541018979	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
999541018980	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
999541018981	pantoate--beta-alanine ligase; Region: panC; TIGR00018
999541018982	Pantoate-beta-alanine ligase; Region: PanC; cd00560
999541018983	active site
999541018984	ATP-binding site [chemical binding]; other site
999541018985	pantoate-binding site; other site
999541018986	HXXH motif; other site
999541018987	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
999541018988	tetramerization interface [polypeptide binding]; other site
999541018989	active site
999541018990	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
999541018991	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541018992	P-loop; other site
999541018993	Magnesium ion binding site [ion binding]; other site
999541018994	cobyric acid synthase; Provisional; Region: PRK00784
999541018995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541018996	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
999541018997	catalytic triad [active]
999541018998	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
999541018999	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
999541019000	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
999541019001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541019002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541019003	homodimer interface [polypeptide binding]; other site
999541019004	catalytic residue [active]
999541019005	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
999541019006	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
999541019007	cobalamin binding residues [chemical binding]; other site
999541019008	putative BtuC binding residues; other site
999541019009	dimer interface [polypeptide binding]; other site
999541019010	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541019011	catalytic core [active]
999541019012	cobalamin synthase; Reviewed; Region: cobS; PRK00235
999541019013	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
999541019014	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
999541019015	putative dimer interface [polypeptide binding]; other site
999541019016	active site pocket [active]
999541019017	putative cataytic base [active]
999541019018	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
999541019019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541019020	Walker A/P-loop; other site
999541019021	ATP binding site [chemical binding]; other site
999541019022	Q-loop/lid; other site
999541019023	ABC transporter signature motif; other site
999541019024	Walker B; other site
999541019025	D-loop; other site
999541019026	H-loop/switch region; other site
999541019027	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
999541019028	dimer interface [polypeptide binding]; other site
999541019029	putative PBP binding regions; other site
999541019030	ABC-ATPase subunit  interface; other site
999541019031	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
999541019032	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541019033	N-terminal plug; other site
999541019034	ligand-binding site [chemical binding]; other site
999541019035	Cell division protein ZapA; Region: ZapA; pfam05164
999541019036	Uncharacterized conserved protein [Function unknown]; Region: COG2947
999541019037	Protein of unknown function (DUF541); Region: SIMPL; cl01077
999541019038	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
999541019039	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
999541019040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019041	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
999541019042	putative dimerization interface [polypeptide binding]; other site
999541019043	putative substrate binding pocket [chemical binding]; other site
999541019044	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
999541019045	Cytochrome c; Region: Cytochrom_C; cl11414
999541019046	Protein of unknown function (DUF2486); Region: DUF2486; pfam10667
999541019047	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
999541019048	multifunctional aminopeptidase A; Provisional; Region: PRK00913
999541019049	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
999541019050	interface (dimer of trimers) [polypeptide binding]; other site
999541019051	Substrate-binding/catalytic site; other site
999541019052	Zn-binding sites [ion binding]; other site
999541019053	Predicted permeases [General function prediction only]; Region: COG0795
999541019054	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
999541019055	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
999541019056	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
999541019057	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
999541019058	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
999541019059	putative active site [active]
999541019060	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
999541019061	active site
999541019062	SAM binding site [chemical binding]; other site
999541019063	homodimer interface [polypeptide binding]; other site
999541019064	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
999541019065	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
999541019066	CysD dimerization site [polypeptide binding]; other site
999541019067	G1 box; other site
999541019068	putative GEF interaction site [polypeptide binding]; other site
999541019069	GTP/Mg2+ binding site [chemical binding]; other site
999541019070	Switch I region; other site
999541019071	G2 box; other site
999541019072	G3 box; other site
999541019073	Switch II region; other site
999541019074	G4 box; other site
999541019075	G5 box; other site
999541019076	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
999541019077	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
999541019078	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
999541019079	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
999541019080	Active Sites [active]
999541019081	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
999541019082	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
999541019083	Active Sites [active]
999541019084	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
999541019085	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
999541019086	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541019087	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
999541019088	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
999541019089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019090	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
999541019091	substrate binding site [chemical binding]; other site
999541019092	dimerization interface [polypeptide binding]; other site
999541019093	integrase; Provisional; Region: PRK09692
999541019094	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
999541019095	active site
999541019096	Int/Topo IB signature motif; other site
999541019097	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
999541019098	Domain of unknown function (DUF927); Region: DUF927; pfam06048
999541019099	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
999541019100	Helix-turn-helix domain; Region: HTH_36; pfam13730
999541019101	Predicted transcriptional regulator [Transcription]; Region: COG3355
999541019102	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
999541019103	multiple promoter invertase; Provisional; Region: mpi; PRK13413
999541019104	catalytic residues [active]
999541019105	catalytic nucleophile [active]
999541019106	Presynaptic Site I dimer interface [polypeptide binding]; other site
999541019107	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
999541019108	Synaptic Flat tetramer interface [polypeptide binding]; other site
999541019109	Synaptic Site I dimer interface [polypeptide binding]; other site
999541019110	DNA binding site [nucleotide binding]
999541019111	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
999541019112	DNA-binding interface [nucleotide binding]; DNA binding site
999541019113	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
999541019114	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
999541019115	PAAR motif; Region: PAAR_motif; pfam05488
999541019116	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541019117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019118	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541019119	putative effector binding pocket; other site
999541019120	dimerization interface [polypeptide binding]; other site
999541019121	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
999541019122	RNA binding surface [nucleotide binding]; other site
999541019123	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
999541019124	pseudouridine synthase; Region: TIGR00093
999541019125	active site
999541019126	uracil binding [chemical binding]; other site
999541019127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541019128	NAD(P) binding site [chemical binding]; other site
999541019129	active site
999541019130	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
999541019131	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
999541019132	catalytic loop [active]
999541019133	iron binding site [ion binding]; other site
999541019134	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
999541019135	FAD binding pocket [chemical binding]; other site
999541019136	FAD binding motif [chemical binding]; other site
999541019137	phosphate binding motif [ion binding]; other site
999541019138	beta-alpha-beta structure motif; other site
999541019139	NAD binding pocket [chemical binding]; other site
999541019140	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
999541019141	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541019142	inhibitor-cofactor binding pocket; inhibition site
999541019143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541019144	catalytic residue [active]
999541019145	putative acetyltransferase; Provisional; Region: PRK03624
999541019146	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541019147	Coenzyme A binding pocket [chemical binding]; other site
999541019148	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
999541019149	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
999541019150	Walker A/P-loop; other site
999541019151	ATP binding site [chemical binding]; other site
999541019152	Q-loop/lid; other site
999541019153	ABC transporter signature motif; other site
999541019154	Walker B; other site
999541019155	D-loop; other site
999541019156	H-loop/switch region; other site
999541019157	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
999541019158	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
999541019159	Walker A/P-loop; other site
999541019160	ATP binding site [chemical binding]; other site
999541019161	Q-loop/lid; other site
999541019162	ABC transporter signature motif; other site
999541019163	Walker B; other site
999541019164	D-loop; other site
999541019165	H-loop/switch region; other site
999541019166	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
999541019167	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
999541019168	TM-ABC transporter signature motif; other site
999541019169	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
999541019170	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
999541019171	TM-ABC transporter signature motif; other site
999541019172	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
999541019173	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
999541019174	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
999541019175	hypothetical protein; Reviewed; Region: PRK00024
999541019176	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
999541019177	MPN+ (JAMM) motif; other site
999541019178	Zinc-binding site [ion binding]; other site
999541019179	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
999541019180	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
999541019181	L-aspartate oxidase; Provisional; Region: PRK09077
999541019182	L-aspartate oxidase; Provisional; Region: PRK06175
999541019183	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
999541019184	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
999541019185	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
999541019186	dimerization interface [polypeptide binding]; other site
999541019187	active site
999541019188	quinolinate synthetase; Provisional; Region: PRK09375
999541019189	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541019190	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541019191	Di-iron ligands [ion binding]; other site
999541019192	Transposase; Region: DDE_Tnp_ISL3; pfam01610
999541019193	Mechanosensitive ion channel; Region: MS_channel; pfam00924
999541019194	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
999541019195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541019196	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
999541019197	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
999541019198	active site
999541019199	substrate binding site [chemical binding]; other site
999541019200	cosubstrate binding site; other site
999541019201	catalytic site [active]
999541019202	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
999541019203	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
999541019204	active site
999541019205	Riboflavin kinase; Region: Flavokinase; smart00904
999541019206	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
999541019207	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
999541019208	active site
999541019209	HIGH motif; other site
999541019210	nucleotide binding site [chemical binding]; other site
999541019211	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
999541019212	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
999541019213	active site
999541019214	KMSKS motif; other site
999541019215	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
999541019216	tRNA binding surface [nucleotide binding]; other site
999541019217	anticodon binding site; other site
999541019218	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
999541019219	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
999541019220	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
999541019221	Flavoprotein; Region: Flavoprotein; pfam02441
999541019222	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
999541019223	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
999541019224	trimer interface [polypeptide binding]; other site
999541019225	active site
999541019226	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
999541019227	Clp amino terminal domain; Region: Clp_N; pfam02861
999541019228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541019229	Walker A motif; other site
999541019230	ATP binding site [chemical binding]; other site
999541019231	Walker B motif; other site
999541019232	arginine finger; other site
999541019233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541019234	Walker A motif; other site
999541019235	ATP binding site [chemical binding]; other site
999541019236	Walker B motif; other site
999541019237	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
999541019238	Uncharacterized conserved protein [Function unknown]; Region: COG2127
999541019239	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
999541019240	DNA-binding site [nucleotide binding]; DNA binding site
999541019241	RNA-binding motif; other site
999541019242	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
999541019243	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
999541019244	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
999541019245	Response regulator receiver domain; Region: Response_reg; pfam00072
999541019246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541019247	active site
999541019248	phosphorylation site [posttranslational modification]
999541019249	intermolecular recognition site; other site
999541019250	dimerization interface [polypeptide binding]; other site
999541019251	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
999541019252	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541019253	putative CheW interface [polypeptide binding]; other site
999541019254	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541019255	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541019256	dimerization interface [polypeptide binding]; other site
999541019257	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
999541019258	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
999541019259	putative binding surface; other site
999541019260	active site
999541019261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541019262	ATP binding site [chemical binding]; other site
999541019263	Mg2+ binding site [ion binding]; other site
999541019264	G-X-G motif; other site
999541019265	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
999541019266	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
999541019267	isocitrate dehydrogenase; Validated; Region: PRK07362
999541019268	isocitrate dehydrogenase; Reviewed; Region: PRK07006
999541019269	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
999541019270	pseudouridine synthase; Region: TIGR00093
999541019271	active site
999541019272	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
999541019273	elongation factor G; Reviewed; Region: PRK00007
999541019274	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
999541019275	G1 box; other site
999541019276	putative GEF interaction site [polypeptide binding]; other site
999541019277	GTP/Mg2+ binding site [chemical binding]; other site
999541019278	Switch I region; other site
999541019279	G2 box; other site
999541019280	G3 box; other site
999541019281	Switch II region; other site
999541019282	G4 box; other site
999541019283	G5 box; other site
999541019284	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
999541019285	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
999541019286	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
999541019287	H+ Antiporter protein; Region: 2A0121; TIGR00900
999541019288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019289	putative substrate translocation pore; other site
999541019290	MarR family; Region: MarR_2; cl17246
999541019291	High-affinity nickel-transport protein; Region: NicO; cl00964
999541019292	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541019293	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541019294	active site
999541019295	catalytic tetrad [active]
999541019296	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
999541019297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541019298	DNA-binding site [nucleotide binding]; DNA binding site
999541019299	UTRA domain; Region: UTRA; pfam07702
999541019300	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541019301	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541019302	MerR family regulatory protein; Region: MerR; pfam00376
999541019303	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
999541019304	dimer interface [polypeptide binding]; other site
999541019305	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
999541019306	active site
999541019307	oxalacetate/citrate binding site [chemical binding]; other site
999541019308	citrylCoA binding site [chemical binding]; other site
999541019309	coenzyme A binding site [chemical binding]; other site
999541019310	catalytic triad [active]
999541019311	putative transporter; Provisional; Region: PRK10504
999541019312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019313	putative substrate translocation pore; other site
999541019314	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541019315	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
999541019316	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
999541019317	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
999541019318	Predicted membrane protein [Function unknown]; Region: COG4539
999541019319	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541019320	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541019321	ligand binding site [chemical binding]; other site
999541019322	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541019323	putative switch regulator; other site
999541019324	non-specific DNA interactions [nucleotide binding]; other site
999541019325	DNA binding site [nucleotide binding]
999541019326	sequence specific DNA binding site [nucleotide binding]; other site
999541019327	putative cAMP binding site [chemical binding]; other site
999541019328	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
999541019329	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541019330	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541019331	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541019332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541019333	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
999541019334	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
999541019335	NADP binding site [chemical binding]; other site
999541019336	substrate binding site [chemical binding]; other site
999541019337	active site
999541019338	superoxide dismutase; Provisional; Region: PRK10543
999541019339	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
999541019340	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
999541019341	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
999541019342	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
999541019343	generic binding surface II; other site
999541019344	generic binding surface I; other site
999541019345	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
999541019346	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
999541019347	Uncharacterized conserved protein [Function unknown]; Region: COG2835
999541019348	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
999541019349	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
999541019350	Ligand binding site; other site
999541019351	oligomer interface; other site
999541019352	adenylate kinase; Reviewed; Region: adk; PRK00279
999541019353	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
999541019354	AMP-binding site [chemical binding]; other site
999541019355	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
999541019356	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
999541019357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541019358	NAD(P) binding site [chemical binding]; other site
999541019359	active site
999541019360	Uncharacterized conserved protein [Function unknown]; Region: COG2912
999541019361	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
999541019362	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
999541019363	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
999541019364	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
999541019365	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
999541019366	ornithine carbamoyltransferase; Provisional; Region: PRK00779
999541019367	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
999541019368	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
999541019369	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
999541019370	FAD binding domain; Region: FAD_binding_4; pfam01565
999541019371	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
999541019372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
999541019373	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
999541019374	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
999541019375	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
999541019376	putative deacylase active site [active]
999541019377	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
999541019378	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541019379	acyl-activating enzyme (AAE) consensus motif; other site
999541019380	AMP binding site [chemical binding]; other site
999541019381	active site
999541019382	CoA binding site [chemical binding]; other site
999541019383	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
999541019384	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
999541019385	active site
999541019386	Int/Topo IB signature motif; other site
999541019387	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
999541019388	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
999541019389	DNA binding site [nucleotide binding]
999541019390	active site
999541019391	epoxyqueuosine reductase; Region: TIGR00276
999541019392	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
999541019393	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
999541019394	AMIN domain; Region: AMIN; pfam11741
999541019395	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
999541019396	active site
999541019397	metal binding site [ion binding]; metal-binding site
999541019398	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
999541019399	EamA-like transporter family; Region: EamA; cl17759
999541019400	EamA-like transporter family; Region: EamA; pfam00892
999541019401	Pirin-related protein [General function prediction only]; Region: COG1741
999541019402	Pirin; Region: Pirin; pfam02678
999541019403	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
999541019404	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
999541019405	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
999541019406	catalytic residues [active]
999541019407	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
999541019408	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
999541019409	putative ATP binding site [chemical binding]; other site
999541019410	putative substrate interface [chemical binding]; other site
999541019411	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
999541019412	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
999541019413	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
999541019414	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
999541019415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541019416	S-adenosylmethionine binding site [chemical binding]; other site
999541019417	Protein of unknown function DUF72; Region: DUF72; pfam01904
999541019418	methionine sulfoxide reductase A; Provisional; Region: PRK14054
999541019419	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
999541019420	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
999541019421	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541019422	putative DNA binding site [nucleotide binding]; other site
999541019423	putative Zn2+ binding site [ion binding]; other site
999541019424	AsnC family; Region: AsnC_trans_reg; pfam01037
999541019425	Putative cyclase; Region: Cyclase; cl00814
999541019426	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
999541019427	kynureninase; Region: kynureninase; TIGR01814
999541019428	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541019429	catalytic residue [active]
999541019430	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
999541019431	benzoate transport; Region: 2A0115; TIGR00895
999541019432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019433	putative substrate translocation pore; other site
999541019434	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
999541019435	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
999541019436	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
999541019437	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
999541019438	N- and C-terminal domain interface [polypeptide binding]; other site
999541019439	D-xylulose kinase; Region: XylB; TIGR01312
999541019440	active site
999541019441	MgATP binding site [chemical binding]; other site
999541019442	catalytic site [active]
999541019443	metal binding site [ion binding]; metal-binding site
999541019444	xylulose binding site [chemical binding]; other site
999541019445	homodimer interface [polypeptide binding]; other site
999541019446	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
999541019447	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
999541019448	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
999541019449	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
999541019450	Walker A/P-loop; other site
999541019451	ATP binding site [chemical binding]; other site
999541019452	Q-loop/lid; other site
999541019453	ABC transporter signature motif; other site
999541019454	Walker B; other site
999541019455	D-loop; other site
999541019456	H-loop/switch region; other site
999541019457	TOBE domain; Region: TOBE; pfam03459
999541019458	TOBE domain; Region: TOBE_2; pfam08402
999541019459	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
999541019460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541019461	motif II; other site
999541019462	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
999541019463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541019464	dimer interface [polypeptide binding]; other site
999541019465	conserved gate region; other site
999541019466	putative PBP binding loops; other site
999541019467	ABC-ATPase subunit interface; other site
999541019468	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
999541019469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
999541019470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541019471	dimer interface [polypeptide binding]; other site
999541019472	conserved gate region; other site
999541019473	putative PBP binding loops; other site
999541019474	ABC-ATPase subunit interface; other site
999541019475	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
999541019476	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
999541019477	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
999541019478	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
999541019479	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
999541019480	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541019481	substrate binding site [chemical binding]; other site
999541019482	ATP binding site [chemical binding]; other site
999541019483	sorbitol dehydrogenase; Provisional; Region: PRK07067
999541019484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541019485	NAD(P) binding site [chemical binding]; other site
999541019486	active site
999541019487	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
999541019488	metal binding site 2 [ion binding]; metal-binding site
999541019489	putative DNA binding helix; other site
999541019490	metal binding site 1 [ion binding]; metal-binding site
999541019491	dimer interface [polypeptide binding]; other site
999541019492	structural Zn2+ binding site [ion binding]; other site
999541019493	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
999541019494	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
999541019495	metal binding site [ion binding]; metal-binding site
999541019496	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
999541019497	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
999541019498	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
999541019499	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
999541019500	ABC-ATPase subunit  interface; other site
999541019501	dimer interface [polypeptide binding]; other site
999541019502	putative PBP binding regions; other site
999541019503	S-formylglutathione hydrolase; Region: PLN02442
999541019504	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
999541019505	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
999541019506	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
999541019507	substrate binding site [chemical binding]; other site
999541019508	catalytic Zn binding site [ion binding]; other site
999541019509	NAD binding site [chemical binding]; other site
999541019510	structural Zn binding site [ion binding]; other site
999541019511	dimer interface [polypeptide binding]; other site
999541019512	xanthine permease; Region: pbuX; TIGR03173
999541019513	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
999541019514	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
999541019515	Protein export membrane protein; Region: SecD_SecF; cl14618
999541019516	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
999541019517	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
999541019518	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541019519	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541019520	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
999541019521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541019522	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
999541019523	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
999541019524	hydrophobic ligand binding site; other site
999541019525	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
999541019526	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
999541019527	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
999541019528	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541019529	protein binding site [polypeptide binding]; other site
999541019530	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
999541019531	protein binding site [polypeptide binding]; other site
999541019532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541019533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541019534	dimer interface [polypeptide binding]; other site
999541019535	phosphorylation site [posttranslational modification]
999541019536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541019537	ATP binding site [chemical binding]; other site
999541019538	Mg2+ binding site [ion binding]; other site
999541019539	G-X-G motif; other site
999541019540	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
999541019541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541019542	active site
999541019543	phosphorylation site [posttranslational modification]
999541019544	intermolecular recognition site; other site
999541019545	dimerization interface [polypeptide binding]; other site
999541019546	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541019547	DNA binding site [nucleotide binding]
999541019548	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
999541019549	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
999541019550	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
999541019551	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
999541019552	active site
999541019553	catalytic triad [active]
999541019554	oxyanion hole [active]
999541019555	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
999541019556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541019557	NAD(P) binding site [chemical binding]; other site
999541019558	active site
999541019559	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
999541019560	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
999541019561	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
999541019562	ATP-grasp domain; Region: ATP-grasp_4; cl17255
999541019563	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
999541019564	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
999541019565	ATP binding site [chemical binding]; other site
999541019566	active site
999541019567	substrate binding site [chemical binding]; other site
999541019568	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
999541019569	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
999541019570	intersubunit interface [polypeptide binding]; other site
999541019571	active site
999541019572	zinc binding site [ion binding]; other site
999541019573	Na+ binding site [ion binding]; other site
999541019574	pyruvate kinase; Provisional; Region: PRK05826
999541019575	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
999541019576	domain interfaces; other site
999541019577	active site
999541019578	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
999541019579	Phosphoglycerate kinase; Region: PGK; pfam00162
999541019580	substrate binding site [chemical binding]; other site
999541019581	hinge regions; other site
999541019582	ADP binding site [chemical binding]; other site
999541019583	catalytic site [active]
999541019584	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
999541019585	AzlC protein; Region: AzlC; cl00570
999541019586	Zinc-finger domain; Region: zf-CHCC; cl01821
999541019587	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
999541019588	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541019589	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
999541019590	putative active site [active]
999541019591	SnoaL-like domain; Region: SnoaL_3; pfam13474
999541019592	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
999541019593	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
999541019594	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
999541019595	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
999541019596	Peptidase family M48; Region: Peptidase_M48; pfam01435
999541019597	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
999541019598	trimer interface [polypeptide binding]; other site
999541019599	dimer interface [polypeptide binding]; other site
999541019600	putative active site [active]
999541019601	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541019602	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541019603	trimer interface [polypeptide binding]; other site
999541019604	eyelet of channel; other site
999541019605	Gram-negative bacterial tonB protein; Region: TonB; cl10048
999541019606	hypothetical protein; Provisional; Region: PRK11667
999541019607	O-Antigen ligase; Region: Wzy_C; pfam04932
999541019608	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
999541019609	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
999541019610	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
999541019611	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
999541019612	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
999541019613	CoA binding domain; Region: CoA_binding; smart00881
999541019614	CoA-ligase; Region: Ligase_CoA; pfam00549
999541019615	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
999541019616	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
999541019617	CoA-ligase; Region: Ligase_CoA; pfam00549
999541019618	RecX family; Region: RecX; cl00936
999541019619	RecX family; Region: RecX; cl00936
999541019620	recombinase A; Provisional; Region: recA; PRK09354
999541019621	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
999541019622	hexamer interface [polypeptide binding]; other site
999541019623	Walker A motif; other site
999541019624	ATP binding site [chemical binding]; other site
999541019625	Walker B motif; other site
999541019626	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541019627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541019628	active site
999541019629	phosphorylation site [posttranslational modification]
999541019630	intermolecular recognition site; other site
999541019631	dimerization interface [polypeptide binding]; other site
999541019632	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541019633	DNA binding site [nucleotide binding]
999541019634	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
999541019635	HAMP domain; Region: HAMP; pfam00672
999541019636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541019637	dimer interface [polypeptide binding]; other site
999541019638	phosphorylation site [posttranslational modification]
999541019639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541019640	ATP binding site [chemical binding]; other site
999541019641	Mg2+ binding site [ion binding]; other site
999541019642	G-X-G motif; other site
999541019643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019644	putative substrate translocation pore; other site
999541019645	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
999541019646	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
999541019647	Int/Topo IB signature motif; other site
999541019648	PAAR motif; Region: PAAR_motif; pfam05488
999541019649	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
999541019650	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
999541019651	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
999541019652	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541019653	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
999541019654	NAD(P) binding site [chemical binding]; other site
999541019655	putative aminotransferase; Provisional; Region: PRK12414
999541019656	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541019657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541019658	homodimer interface [polypeptide binding]; other site
999541019659	catalytic residue [active]
999541019660	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
999541019661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541019662	NAD(P) binding site [chemical binding]; other site
999541019663	active site
999541019664	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
999541019665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541019666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541019667	dimer interface [polypeptide binding]; other site
999541019668	phosphorylation site [posttranslational modification]
999541019669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541019670	ATP binding site [chemical binding]; other site
999541019671	Mg2+ binding site [ion binding]; other site
999541019672	G-X-G motif; other site
999541019673	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
999541019674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541019675	active site
999541019676	phosphorylation site [posttranslational modification]
999541019677	intermolecular recognition site; other site
999541019678	dimerization interface [polypeptide binding]; other site
999541019679	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541019680	DNA binding site [nucleotide binding]
999541019681	citrate-proton symporter; Provisional; Region: PRK15075
999541019682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019683	putative substrate translocation pore; other site
999541019684	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
999541019685	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
999541019686	NADP binding site [chemical binding]; other site
999541019687	dimer interface [polypeptide binding]; other site
999541019688	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
999541019689	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
999541019690	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541019691	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541019692	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541019693	Coenzyme A binding pocket [chemical binding]; other site
999541019694	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
999541019695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019696	putative substrate translocation pore; other site
999541019697	Domain of unknown function (DUF336); Region: DUF336; cl01249
999541019698	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541019699	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019700	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
999541019701	putative effector binding pocket; other site
999541019702	putative dimerization interface [polypeptide binding]; other site
999541019703	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
999541019704	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541019705	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541019706	trimer interface [polypeptide binding]; other site
999541019707	eyelet of channel; other site
999541019708	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
999541019709	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
999541019710	putative di-iron ligands [ion binding]; other site
999541019711	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541019712	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541019713	trimer interface [polypeptide binding]; other site
999541019714	eyelet of channel; other site
999541019715	citrate-proton symporter; Provisional; Region: PRK15075
999541019716	hypothetical protein; Provisional; Region: PRK08201
999541019717	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
999541019718	metal binding site [ion binding]; metal-binding site
999541019719	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
999541019720	Carboxylesterase family; Region: COesterase; pfam00135
999541019721	substrate binding pocket [chemical binding]; other site
999541019722	catalytic triad [active]
999541019723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541019724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
999541019726	dimerization interface [polypeptide binding]; other site
999541019727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019728	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541019729	putative substrate translocation pore; other site
999541019730	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
999541019731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019732	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541019733	dimerization interface [polypeptide binding]; other site
999541019734	substrate binding pocket [chemical binding]; other site
999541019735	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
999541019736	Transglycosylase; Region: Transgly; pfam00912
999541019737	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
999541019738	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
999541019739	active site
999541019740	metal binding site [ion binding]; metal-binding site
999541019741	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
999541019742	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541019743	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
999541019744	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
999541019745	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541019746	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541019747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019748	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541019749	putative substrate translocation pore; other site
999541019750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019751	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541019752	Transcriptional regulators [Transcription]; Region: FadR; COG2186
999541019753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
999541019754	DNA-binding site [nucleotide binding]; DNA binding site
999541019755	FCD domain; Region: FCD; cl11656
999541019756	galactonate dehydratase; Provisional; Region: PRK14017
999541019757	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
999541019758	putative active site pocket [active]
999541019759	putative metal binding site [ion binding]; other site
999541019760	Cytochrome c; Region: Cytochrom_C; cl11414
999541019761	Cytochrome c; Region: Cytochrom_C; cl11414
999541019762	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541019763	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541019764	Cytochrome c; Region: Cytochrom_C; pfam00034
999541019765	helicase 45; Provisional; Region: PTZ00424
999541019766	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
999541019767	ATP binding site [chemical binding]; other site
999541019768	Mg++ binding site [ion binding]; other site
999541019769	motif III; other site
999541019770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541019771	nucleotide binding region [chemical binding]; other site
999541019772	ATP-binding site [chemical binding]; other site
999541019773	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541019774	dinuclear metal binding motif [ion binding]; other site
999541019775	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
999541019776	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
999541019777	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
999541019778	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
999541019779	glycerol kinase; Provisional; Region: glpK; PRK00047
999541019780	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
999541019781	N- and C-terminal domain interface [polypeptide binding]; other site
999541019782	active site
999541019783	MgATP binding site [chemical binding]; other site
999541019784	catalytic site [active]
999541019785	metal binding site [ion binding]; metal-binding site
999541019786	glycerol binding site [chemical binding]; other site
999541019787	homotetramer interface [polypeptide binding]; other site
999541019788	homodimer interface [polypeptide binding]; other site
999541019789	FBP binding site [chemical binding]; other site
999541019790	protein IIAGlc interface [polypeptide binding]; other site
999541019791	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
999541019792	amphipathic channel; other site
999541019793	Asn-Pro-Ala signature motifs; other site
999541019794	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
999541019795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541019796	motif II; other site
999541019797	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
999541019798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541019799	non-specific DNA binding site [nucleotide binding]; other site
999541019800	salt bridge; other site
999541019801	sequence-specific DNA binding site [nucleotide binding]; other site
999541019802	Cupin domain; Region: Cupin_2; pfam07883
999541019803	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
999541019804	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
999541019805	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541019806	FeS/SAM binding site; other site
999541019807	TRAM domain; Region: TRAM; pfam01938
999541019808	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
999541019809	PhoH-like protein; Region: PhoH; pfam02562
999541019810	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
999541019811	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
999541019812	putative active site pocket [active]
999541019813	dimerization interface [polypeptide binding]; other site
999541019814	putative catalytic residue [active]
999541019815	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
999541019816	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
999541019817	Transporter associated domain; Region: CorC_HlyC; smart01091
999541019818	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
999541019819	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
999541019820	putative active site [active]
999541019821	catalytic triad [active]
999541019822	putative dimer interface [polypeptide binding]; other site
999541019823	TPR repeat; Region: TPR_11; pfam13414
999541019824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541019825	binding surface
999541019826	TPR motif; other site
999541019827	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
999541019828	dimer interface [polypeptide binding]; other site
999541019829	motif 1; other site
999541019830	active site
999541019831	motif 2; other site
999541019832	motif 3; other site
999541019833	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
999541019834	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
999541019835	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541019836	active site
999541019837	motif I; other site
999541019838	motif II; other site
999541019839	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
999541019840	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
999541019841	putative acyl-acceptor binding pocket; other site
999541019842	Protein of unknown function DUF45; Region: DUF45; pfam01863
999541019843	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541019844	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
999541019845	dimer interface [polypeptide binding]; other site
999541019846	active site
999541019847	metal binding site [ion binding]; metal-binding site
999541019848	glutathione binding site [chemical binding]; other site
999541019849	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
999541019850	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
999541019851	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
999541019852	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
999541019853	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
999541019854	SurA N-terminal domain; Region: SurA_N; pfam09312
999541019855	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
999541019856	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
999541019857	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
999541019858	Organic solvent tolerance protein; Region: OstA_C; pfam04453
999541019859	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
999541019860	Phosphotransferase enzyme family; Region: APH; pfam01636
999541019861	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
999541019862	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
999541019863	Substrate binding site; other site
999541019864	metal-binding site
999541019865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541019866	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
999541019867	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541019868	Walker A/P-loop; other site
999541019869	ATP binding site [chemical binding]; other site
999541019870	Q-loop/lid; other site
999541019871	ABC transporter signature motif; other site
999541019872	Walker B; other site
999541019873	D-loop; other site
999541019874	H-loop/switch region; other site
999541019875	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
999541019876	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869
999541019877	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
999541019878	enoyl-CoA hydratase; Provisional; Region: PRK06688
999541019879	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541019880	substrate binding site [chemical binding]; other site
999541019881	oxyanion hole (OAH) forming residues; other site
999541019882	trimer interface [polypeptide binding]; other site
999541019883	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
999541019884	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541019885	dimer interface [polypeptide binding]; other site
999541019886	active site
999541019887	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
999541019888	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
999541019889	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541019890	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
999541019891	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541019892	substrate binding site [chemical binding]; other site
999541019893	oxyanion hole (OAH) forming residues; other site
999541019894	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
999541019895	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
999541019896	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
999541019897	FAD binding site [chemical binding]; other site
999541019898	substrate binding site [chemical binding]; other site
999541019899	catalytic residues [active]
999541019900	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
999541019901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541019902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541019903	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
999541019904	PLD-like domain; Region: PLDc_2; pfam13091
999541019905	putative active site [active]
999541019906	catalytic site [active]
999541019907	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
999541019908	PLD-like domain; Region: PLDc_2; pfam13091
999541019909	putative active site [active]
999541019910	catalytic site [active]
999541019911	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
999541019912	Predicted permeases [General function prediction only]; Region: COG0679
999541019913	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
999541019914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541019915	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
999541019916	dimerization interface [polypeptide binding]; other site
999541019917	substrate binding pocket [chemical binding]; other site
999541019918	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
999541019919	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
999541019920	dimer interface [polypeptide binding]; other site
999541019921	anticodon binding site; other site
999541019922	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
999541019923	homodimer interface [polypeptide binding]; other site
999541019924	motif 1; other site
999541019925	active site
999541019926	motif 2; other site
999541019927	GAD domain; Region: GAD; pfam02938
999541019928	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
999541019929	motif 3; other site
999541019930	Uncharacterized conserved protein [Function unknown]; Region: COG2928
999541019931	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
999541019932	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
999541019933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
999541019934	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
999541019935	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
999541019936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
999541019937	SCP-2 sterol transfer family; Region: SCP2; pfam02036
999541019938	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
999541019939	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
999541019940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541019941	S-adenosylmethionine binding site [chemical binding]; other site
999541019942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
999541019943	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
999541019944	nucleotide binding site/active site [active]
999541019945	HIT family signature motif; other site
999541019946	catalytic residue [active]
999541019947	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
999541019948	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541019949	FAD binding domain; Region: FAD_binding_4; pfam01565
999541019950	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541019951	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
999541019952	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
999541019953	Cysteine-rich domain; Region: CCG; pfam02754
999541019954	Cysteine-rich domain; Region: CCG; pfam02754
999541019955	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
999541019956	threonine dehydratase; Reviewed; Region: PRK09224
999541019957	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
999541019958	tetramer interface [polypeptide binding]; other site
999541019959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541019960	catalytic residue [active]
999541019961	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
999541019962	putative Ile/Val binding site [chemical binding]; other site
999541019963	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
999541019964	putative Ile/Val binding site [chemical binding]; other site
999541019965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
999541019966	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
999541019967	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
999541019968	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
999541019969	homotrimer interaction site [polypeptide binding]; other site
999541019970	putative active site [active]
999541019971	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
999541019972	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
999541019973	active site
999541019974	putative substrate binding pocket [chemical binding]; other site
999541019975	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
999541019976	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
999541019977	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
999541019978	putative active site [active]
999541019979	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
999541019980	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
999541019981	dimer interface [polypeptide binding]; other site
999541019982	active site
999541019983	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
999541019984	substrate binding site [chemical binding]; other site
999541019985	catalytic residue [active]
999541019986	intracellular protease, PfpI family; Region: PfpI; TIGR01382
999541019987	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
999541019988	conserved cys residue [active]
999541019989	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541019990	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
999541019991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019992	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541019993	putative substrate translocation pore; other site
999541019994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541019995	EcsC protein family; Region: EcsC; pfam12787
999541019996	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541019997	CHRD domain; Region: CHRD; pfam07452
999541019998	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
999541019999	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
999541020000	short chain dehydrogenase; Provisional; Region: PRK06500
999541020001	classical (c) SDRs; Region: SDR_c; cd05233
999541020002	NAD(P) binding site [chemical binding]; other site
999541020003	active site
999541020004	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
999541020005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020006	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541020007	dimerization interface [polypeptide binding]; other site
999541020008	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541020009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541020010	putative substrate translocation pore; other site
999541020011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541020012	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
999541020013	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541020014	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
999541020015	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541020016	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541020017	MarR family; Region: MarR; pfam01047
999541020018	MarR family; Region: MarR_2; cl17246
999541020019	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541020020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541020021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020022	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541020023	putative effector binding pocket; other site
999541020024	dimerization interface [polypeptide binding]; other site
999541020025	short chain dehydrogenase; Provisional; Region: PRK12744
999541020026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541020027	NAD(P) binding site [chemical binding]; other site
999541020028	active site
999541020029	Helix-turn-helix domain; Region: HTH_18; pfam12833
999541020030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020031	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541020032	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020033	Chitin binding domain; Region: Chitin_bind_3; pfam03067
999541020034	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
999541020035	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
999541020036	TrkA-C domain; Region: TrkA_C; pfam02080
999541020037	TrkA-C domain; Region: TrkA_C; pfam02080
999541020038	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
999541020039	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
999541020040	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541020041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541020042	homodimer interface [polypeptide binding]; other site
999541020043	catalytic residue [active]
999541020044	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
999541020045	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
999541020046	dimer interface [polypeptide binding]; other site
999541020047	ssDNA binding site [nucleotide binding]; other site
999541020048	tetramer (dimer of dimers) interface [polypeptide binding]; other site
999541020049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541020050	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541020051	putative substrate translocation pore; other site
999541020052	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
999541020053	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
999541020054	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
999541020055	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
999541020056	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
999541020057	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
999541020058	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
999541020059	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
999541020060	putative active site [active]
999541020061	putative substrate binding site [chemical binding]; other site
999541020062	putative cosubstrate binding site; other site
999541020063	catalytic site [active]
999541020064	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676
999541020065	nudix motif; other site
999541020066	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541020067	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541020068	active site
999541020069	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
999541020070	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
999541020071	TrkA-N domain; Region: TrkA_N; pfam02254
999541020072	TrkA-C domain; Region: TrkA_C; pfam02080
999541020073	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
999541020074	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
999541020075	putative active site [active]
999541020076	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
999541020077	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
999541020078	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
999541020079	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
999541020080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
999541020081	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
999541020082	OstA-like protein; Region: OstA; pfam03968
999541020083	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
999541020084	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
999541020085	Walker A/P-loop; other site
999541020086	ATP binding site [chemical binding]; other site
999541020087	Q-loop/lid; other site
999541020088	ABC transporter signature motif; other site
999541020089	Walker B; other site
999541020090	D-loop; other site
999541020091	H-loop/switch region; other site
999541020092	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
999541020093	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
999541020094	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
999541020095	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
999541020096	30S subunit binding site; other site
999541020097	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
999541020098	active site
999541020099	phosphorylation site [posttranslational modification]
999541020100	HPr kinase/phosphorylase; Provisional; Region: PRK05428
999541020101	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
999541020102	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
999541020103	Hpr binding site; other site
999541020104	active site
999541020105	homohexamer subunit interaction site [polypeptide binding]; other site
999541020106	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
999541020107	AAA domain; Region: AAA_18; pfam13238
999541020108	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
999541020109	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
999541020110	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
999541020111	minor groove reading motif; other site
999541020112	helix-hairpin-helix signature motif; other site
999541020113	substrate binding pocket [chemical binding]; other site
999541020114	active site
999541020115	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
999541020116	DNA binding and oxoG recognition site [nucleotide binding]
999541020117	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
999541020118	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
999541020119	DNA binding site [nucleotide binding]
999541020120	catalytic residue [active]
999541020121	H2TH interface [polypeptide binding]; other site
999541020122	putative catalytic residues [active]
999541020123	turnover-facilitating residue; other site
999541020124	intercalation triad [nucleotide binding]; other site
999541020125	8OG recognition residue [nucleotide binding]; other site
999541020126	putative reading head residues; other site
999541020127	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
999541020128	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
999541020129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541020130	TPR motif; other site
999541020131	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
999541020132	binding surface
999541020133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541020134	binding surface
999541020135	TPR motif; other site
999541020136	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541020137	binding surface
999541020138	TPR motif; other site
999541020139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
999541020140	binding surface
999541020141	TPR motif; other site
999541020142	TPR repeat; Region: TPR_11; pfam13414
999541020143	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
999541020144	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
999541020145	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
999541020146	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
999541020147	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
999541020148	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
999541020149	active site
999541020150	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
999541020151	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
999541020152	5S rRNA interface [nucleotide binding]; other site
999541020153	CTC domain interface [polypeptide binding]; other site
999541020154	L16 interface [polypeptide binding]; other site
999541020155	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
999541020156	putative active site [active]
999541020157	catalytic residue [active]
999541020158	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
999541020159	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
999541020160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541020161	homodimer interface [polypeptide binding]; other site
999541020162	catalytic residue [active]
999541020163	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
999541020164	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
999541020165	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
999541020166	active site
999541020167	(T/H)XGH motif; other site
999541020168	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
999541020169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541020170	S-adenosylmethionine binding site [chemical binding]; other site
999541020171	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
999541020172	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
999541020173	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
999541020174	P loop; other site
999541020175	GTP binding site [chemical binding]; other site
999541020176	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
999541020177	maleylacetoacetate isomerase; Region: maiA; TIGR01262
999541020178	C-terminal domain interface [polypeptide binding]; other site
999541020179	GSH binding site (G-site) [chemical binding]; other site
999541020180	putative dimer interface [polypeptide binding]; other site
999541020181	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
999541020182	dimer interface [polypeptide binding]; other site
999541020183	N-terminal domain interface [polypeptide binding]; other site
999541020184	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
999541020185	glycosyl transferase family protein; Provisional; Region: PRK08136
999541020186	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
999541020187	2-isopropylmalate synthase; Validated; Region: PRK03739
999541020188	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
999541020189	active site
999541020190	catalytic residues [active]
999541020191	metal binding site [ion binding]; metal-binding site
999541020192	SnoaL-like domain; Region: SnoaL_3; pfam13474
999541020193	SnoaL-like domain; Region: SnoaL_2; pfam12680
999541020194	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
999541020195	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
999541020196	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
999541020197	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541020198	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541020199	DNA binding residues [nucleotide binding]
999541020200	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
999541020201	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
999541020202	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
999541020203	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
999541020204	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
999541020205	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
999541020206	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
999541020207	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
999541020208	active site turn [active]
999541020209	phosphorylation site [posttranslational modification]
999541020210	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
999541020211	HPr interaction site; other site
999541020212	glycerol kinase (GK) interaction site [polypeptide binding]; other site
999541020213	active site
999541020214	phosphorylation site [posttranslational modification]
999541020215	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
999541020216	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
999541020217	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
999541020218	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
999541020219	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
999541020220	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
999541020221	dimer interface [polypeptide binding]; other site
999541020222	active site
999541020223	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
999541020224	dimer interface [polypeptide binding]; other site
999541020225	active site
999541020226	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
999541020227	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
999541020228	active site
999541020229	dimer interface [polypeptide binding]; other site
999541020230	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541020231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020232	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
999541020233	substrate binding site [chemical binding]; other site
999541020234	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
999541020235	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
999541020236	putative active site [active]
999541020237	putative PHP Thumb interface [polypeptide binding]; other site
999541020238	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
999541020239	generic binding surface II; other site
999541020240	generic binding surface I; other site
999541020241	DNA Polymerase Y-family; Region: PolY_like; cd03468
999541020242	active site
999541020243	DNA binding site [nucleotide binding]
999541020244	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
999541020245	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
999541020246	YCII-related domain; Region: YCII; cl00999
999541020247	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
999541020248	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541020249	Cu(I) binding site [ion binding]; other site
999541020250	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
999541020251	UbiA prenyltransferase family; Region: UbiA; pfam01040
999541020252	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
999541020253	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
999541020254	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
999541020255	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
999541020256	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
999541020257	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
999541020258	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
999541020259	Subunit III/VIIa interface [polypeptide binding]; other site
999541020260	Phospholipid binding site [chemical binding]; other site
999541020261	Subunit I/III interface [polypeptide binding]; other site
999541020262	Subunit III/VIb interface [polypeptide binding]; other site
999541020263	Subunit III/VIa interface; other site
999541020264	Subunit III/Vb interface [polypeptide binding]; other site
999541020265	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
999541020266	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
999541020267	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
999541020268	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
999541020269	Subunit I/III interface [polypeptide binding]; other site
999541020270	D-pathway; other site
999541020271	Subunit I/VIIc interface [polypeptide binding]; other site
999541020272	Subunit I/IV interface [polypeptide binding]; other site
999541020273	Subunit I/II interface [polypeptide binding]; other site
999541020274	Low-spin heme (heme a) binding site [chemical binding]; other site
999541020275	Subunit I/VIIa interface [polypeptide binding]; other site
999541020276	Subunit I/VIa interface [polypeptide binding]; other site
999541020277	Dimer interface; other site
999541020278	Putative water exit pathway; other site
999541020279	Binuclear center (heme a3/CuB) [ion binding]; other site
999541020280	K-pathway; other site
999541020281	Subunit I/Vb interface [polypeptide binding]; other site
999541020282	Putative proton exit pathway; other site
999541020283	Subunit I/VIb interface; other site
999541020284	Subunit I/VIc interface [polypeptide binding]; other site
999541020285	Electron transfer pathway; other site
999541020286	Subunit I/VIIIb interface [polypeptide binding]; other site
999541020287	Subunit I/VIIb interface [polypeptide binding]; other site
999541020288	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
999541020289	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
999541020290	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
999541020291	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
999541020292	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
999541020293	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541020294	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
999541020295	ligand binding site [chemical binding]; other site
999541020296	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
999541020297	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
999541020298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541020299	S-adenosylmethionine binding site [chemical binding]; other site
999541020300	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
999541020301	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
999541020302	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
999541020303	putative ADP-ribose binding site [chemical binding]; other site
999541020304	putative active site [active]
999541020305	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
999541020306	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
999541020307	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
999541020308	preprotein translocase subunit SecB; Validated; Region: PRK05751
999541020309	SecA binding site; other site
999541020310	Preprotein binding site; other site
999541020311	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
999541020312	GSH binding site [chemical binding]; other site
999541020313	catalytic residues [active]
999541020314	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
999541020315	active site residue [active]
999541020316	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541020317	catalytic core [active]
999541020318	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
999541020319	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
999541020320	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
999541020321	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
999541020322	protein binding site [polypeptide binding]; other site
999541020323	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
999541020324	Catalytic dyad [active]
999541020325	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
999541020326	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
999541020327	ATP binding site [chemical binding]; other site
999541020328	substrate interface [chemical binding]; other site
999541020329	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
999541020330	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
999541020331	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
999541020332	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
999541020333	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
999541020334	dimerization domain swap beta strand [polypeptide binding]; other site
999541020335	regulatory protein interface [polypeptide binding]; other site
999541020336	active site
999541020337	regulatory phosphorylation site [posttranslational modification]; other site
999541020338	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
999541020339	active pocket/dimerization site; other site
999541020340	active site
999541020341	phosphorylation site [posttranslational modification]
999541020342	glutathione synthetase; Provisional; Region: PRK05246
999541020343	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
999541020344	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
999541020345	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
999541020346	Glutamate-cysteine ligase; Region: GshA; pfam08886
999541020347	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
999541020348	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
999541020349	Nitrogen regulatory protein P-II; Region: P-II; smart00938
999541020350	Membrane fusogenic activity; Region: BMFP; pfam04380
999541020351	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
999541020352	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
999541020353	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
999541020354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541020355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
999541020356	Walker A motif; other site
999541020357	ATP binding site [chemical binding]; other site
999541020358	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
999541020359	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
999541020360	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
999541020361	catalytic residues [active]
999541020362	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
999541020363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541020364	active site
999541020365	phosphorylation site [posttranslational modification]
999541020366	intermolecular recognition site; other site
999541020367	dimerization interface [polypeptide binding]; other site
999541020368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541020369	Walker A motif; other site
999541020370	ATP binding site [chemical binding]; other site
999541020371	Walker B motif; other site
999541020372	arginine finger; other site
999541020373	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
999541020374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541020375	dimer interface [polypeptide binding]; other site
999541020376	phosphorylation site [posttranslational modification]
999541020377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541020378	Mg2+ binding site [ion binding]; other site
999541020379	G-X-G motif; other site
999541020380	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
999541020381	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
999541020382	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
999541020383	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
999541020384	active site
999541020385	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
999541020386	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
999541020387	FAD binding site [chemical binding]; other site
999541020388	substrate binding site [chemical binding]; other site
999541020389	catalytic base [active]
999541020390	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541020391	substrate binding site [chemical binding]; other site
999541020392	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
999541020393	oxyanion hole (OAH) forming residues; other site
999541020394	trimer interface [polypeptide binding]; other site
999541020395	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
999541020396	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541020397	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
999541020398	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541020399	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020400	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541020401	putative effector binding pocket; other site
999541020402	dimerization interface [polypeptide binding]; other site
999541020403	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
999541020404	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
999541020405	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
999541020406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541020407	putative PBP binding loops; other site
999541020408	dimer interface [polypeptide binding]; other site
999541020409	ABC-ATPase subunit interface; other site
999541020410	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
999541020411	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
999541020412	Walker A/P-loop; other site
999541020413	ATP binding site [chemical binding]; other site
999541020414	Q-loop/lid; other site
999541020415	ABC transporter signature motif; other site
999541020416	Walker B; other site
999541020417	D-loop; other site
999541020418	H-loop/switch region; other site
999541020419	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
999541020420	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541020421	substrate binding pocket [chemical binding]; other site
999541020422	membrane-bound complex binding site; other site
999541020423	hinge residues; other site
999541020424	lipoyl synthase; Provisional; Region: PRK05481
999541020425	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541020426	FeS/SAM binding site; other site
999541020427	lipoate-protein ligase B; Provisional; Region: PRK14343
999541020428	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
999541020429	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541020430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020431	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541020432	dimerization interface [polypeptide binding]; other site
999541020433	substrate binding pocket [chemical binding]; other site
999541020434	hypothetical protein; Provisional; Region: PRK02047
999541020435	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
999541020436	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
999541020437	homodimer interface [polypeptide binding]; other site
999541020438	substrate-cofactor binding pocket; other site
999541020439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541020440	catalytic residue [active]
999541020441	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
999541020442	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
999541020443	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
999541020444	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
999541020445	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
999541020446	dimer interface [polypeptide binding]; other site
999541020447	[2Fe-2S] cluster binding site [ion binding]; other site
999541020448	Predicted integral membrane protein [Function unknown]; Region: COG5652
999541020449	Protein of unknown function (DUF330); Region: DUF330; cl01135
999541020450	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
999541020451	mce related protein; Region: MCE; pfam02470
999541020452	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
999541020453	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
999541020454	Walker A/P-loop; other site
999541020455	ATP binding site [chemical binding]; other site
999541020456	Q-loop/lid; other site
999541020457	ABC transporter signature motif; other site
999541020458	Walker B; other site
999541020459	D-loop; other site
999541020460	H-loop/switch region; other site
999541020461	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
999541020462	Permease; Region: Permease; pfam02405
999541020463	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
999541020464	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
999541020465	active site
999541020466	metal binding site [ion binding]; metal-binding site
999541020467	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
999541020468	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541020469	Sel1-like repeats; Region: SEL1; smart00671
999541020470	biotin--protein ligase; Provisional; Region: PRK06955
999541020471	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
999541020472	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
999541020473	pantothenate kinase; Reviewed; Region: PRK13328
999541020474	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
999541020475	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
999541020476	PAAR motif; Region: PAAR_motif; pfam05488
999541020477	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
999541020478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541020479	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541020480	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541020481	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541020482	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541020483	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
999541020484	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
999541020485	active site
999541020486	nucleotide binding site [chemical binding]; other site
999541020487	HIGH motif; other site
999541020488	KMSKS motif; other site
999541020489	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
999541020490	dinuclear metal binding motif [ion binding]; other site
999541020491	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
999541020492	active site
999541020493	nucleophile elbow; other site
999541020494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
999541020495	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
999541020496	substrate binding site [chemical binding]; other site
999541020497	oxyanion hole (OAH) forming residues; other site
999541020498	trimer interface [polypeptide binding]; other site
999541020499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
999541020500	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
999541020501	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
999541020502	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
999541020503	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541020504	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
999541020505	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
999541020506	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
999541020507	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
999541020508	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
999541020509	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
999541020510	substrate binding pocket [chemical binding]; other site
999541020511	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
999541020512	B12 binding site [chemical binding]; other site
999541020513	cobalt ligand [ion binding]; other site
999541020514	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
999541020515	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
999541020516	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
999541020517	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
999541020518	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
999541020519	active site
999541020520	HIGH motif; other site
999541020521	KMSK motif region; other site
999541020522	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
999541020523	tRNA binding surface [nucleotide binding]; other site
999541020524	anticodon binding site; other site
999541020525	Sporulation related domain; Region: SPOR; pfam05036
999541020526	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
999541020527	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
999541020528	catalytic residues [active]
999541020529	hinge region; other site
999541020530	alpha helical domain; other site
999541020531	short chain dehydrogenase; Provisional; Region: PRK07024
999541020532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
999541020533	NAD(P) binding site [chemical binding]; other site
999541020534	active site
999541020535	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
999541020536	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
999541020537	peptide binding site [polypeptide binding]; other site
999541020538	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
999541020539	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
999541020540	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
999541020541	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
999541020542	active site clefts [active]
999541020543	zinc binding site [ion binding]; other site
999541020544	dimer interface [polypeptide binding]; other site
999541020545	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
999541020546	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541020547	dimer interface [polypeptide binding]; other site
999541020548	active site
999541020549	short chain dehydrogenase; Provisional; Region: PRK06953
999541020550	NAD(P) binding site [chemical binding]; other site
999541020551	active site
999541020552	hypothetical protein; Provisional; Region: PRK01842
999541020553	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
999541020554	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541020555	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
999541020556	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
999541020557	inhibitor-cofactor binding pocket; inhibition site
999541020558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541020559	catalytic residue [active]
999541020560	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
999541020561	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
999541020562	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541020563	catalytic residue [active]
999541020564	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
999541020565	AAA domain; Region: AAA_26; pfam13500
999541020566	biotin synthase; Region: bioB; TIGR00433
999541020567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541020568	FeS/SAM binding site; other site
999541020569	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
999541020570	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
999541020571	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541020572	MULE transposase domain; Region: MULE; pfam10551
999541020573	Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808
999541020574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541020575	HTH-like domain; Region: HTH_21; pfam13276
999541020576	Integrase core domain; Region: rve; pfam00665
999541020577	Integrase core domain; Region: rve_3; pfam13683
999541020578	Transposase; Region: HTH_Tnp_1; pfam01527
999541020579	haemagglutination activity domain; Region: Haemagg_act; pfam05860
999541020580	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
999541020581	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
999541020582	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
999541020583	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
999541020584	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541020585	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
999541020586	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
999541020587	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
999541020588	dimer interface [polypeptide binding]; other site
999541020589	PYR/PP interface [polypeptide binding]; other site
999541020590	TPP binding site [chemical binding]; other site
999541020591	substrate binding site [chemical binding]; other site
999541020592	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
999541020593	TPP-binding site; other site
999541020594	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
999541020595	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
999541020596	putative DNA binding site [nucleotide binding]; other site
999541020597	putative Zn2+ binding site [ion binding]; other site
999541020598	Sodium Bile acid symporter family; Region: SBF; cl17470
999541020599	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
999541020600	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
999541020601	ArsC family; Region: ArsC; pfam03960
999541020602	catalytic residues [active]
999541020603	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
999541020604	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
999541020605	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
999541020606	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
999541020607	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
999541020608	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
999541020609	dimer interface [polypeptide binding]; other site
999541020610	active site
999541020611	catalytic residue [active]
999541020612	Serine hydrolase; Region: Ser_hydrolase; pfam06821
999541020613	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541020614	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
999541020615	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
999541020616	putative ligand binding site [chemical binding]; other site
999541020617	NAD binding site [chemical binding]; other site
999541020618	dimerization interface [polypeptide binding]; other site
999541020619	catalytic site [active]
999541020620	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
999541020621	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
999541020622	active site
999541020623	catalytic residues [active]
999541020624	metal binding site [ion binding]; metal-binding site
999541020625	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
999541020626	putative deacylase active site [active]
999541020627	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
999541020628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541020629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020630	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
999541020631	putative effector binding pocket; other site
999541020632	putative dimerization interface [polypeptide binding]; other site
999541020633	short chain dehydrogenase; Provisional; Region: PRK12937
999541020634	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
999541020635	NADP binding site [chemical binding]; other site
999541020636	homodimer interface [polypeptide binding]; other site
999541020637	active site
999541020638	substrate binding site [chemical binding]; other site
999541020639	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
999541020640	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
999541020641	NADP binding site [chemical binding]; other site
999541020642	active site
999541020643	steroid binding site; other site
999541020644	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
999541020645	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
999541020646	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
999541020647	FMN binding site [chemical binding]; other site
999541020648	substrate binding site [chemical binding]; other site
999541020649	putative catalytic residue [active]
999541020650	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541020651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020652	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541020653	putative effector binding pocket; other site
999541020654	dimerization interface [polypeptide binding]; other site
999541020655	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541020656	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541020657	trimer interface [polypeptide binding]; other site
999541020658	eyelet of channel; other site
999541020659	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
999541020660	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
999541020661	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541020662	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
999541020663	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541020664	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541020665	metal binding site [ion binding]; metal-binding site
999541020666	active site
999541020667	I-site; other site
999541020668	Transcriptional regulators [Transcription]; Region: PurR; COG1609
999541020669	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
999541020670	DNA binding site [nucleotide binding]
999541020671	domain linker motif; other site
999541020672	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
999541020673	ligand binding site [chemical binding]; other site
999541020674	dimerization interface [polypeptide binding]; other site
999541020675	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
999541020676	dimerization interface [polypeptide binding]; other site
999541020677	putative active cleft [active]
999541020678	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
999541020679	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
999541020680	putative substrate binding site [chemical binding]; other site
999541020681	putative ATP binding site [chemical binding]; other site
999541020682	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
999541020683	Uncharacterized conserved protein [Function unknown]; Region: COG1565
999541020684	short chain dehydrogenase; Provisional; Region: PRK09134
999541020685	Dihydroneopterin aldolase; Region: FolB; smart00905
999541020686	active site
999541020687	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
999541020688	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
999541020689	Ligand Binding Site [chemical binding]; other site
999541020690	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
999541020691	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
999541020692	Substrate binding site; other site
999541020693	Mg++ binding site; other site
999541020694	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
999541020695	active site
999541020696	substrate binding site [chemical binding]; other site
999541020697	CoA binding site [chemical binding]; other site
999541020698	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
999541020699	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
999541020700	glutaminase active site [active]
999541020701	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
999541020702	dimer interface [polypeptide binding]; other site
999541020703	active site
999541020704	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
999541020705	dimer interface [polypeptide binding]; other site
999541020706	active site
999541020707	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
999541020708	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541020709	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
999541020710	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541020711	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
999541020712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541020713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541020714	Coenzyme A binding pocket [chemical binding]; other site
999541020715	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
999541020716	Transcriptional regulator [Transcription]; Region: IclR; COG1414
999541020717	Bacterial transcriptional regulator; Region: IclR; pfam01614
999541020718	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
999541020719	active site
999541020720	catalytic residues [active]
999541020721	metal binding site [ion binding]; metal-binding site
999541020722	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541020723	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541020724	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
999541020725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541020726	putative substrate translocation pore; other site
999541020727	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
999541020728	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541020729	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
999541020730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541020731	Coenzyme A binding pocket [chemical binding]; other site
999541020732	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
999541020733	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
999541020734	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541020735	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
999541020736	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541020737	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
999541020738	dimer interface [polypeptide binding]; other site
999541020739	active site
999541020740	metal binding site [ion binding]; metal-binding site
999541020741	glutathione binding site [chemical binding]; other site
999541020742	Cytochrome c; Region: Cytochrom_C; cl11414
999541020743	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
999541020744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020745	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541020746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020747	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
999541020748	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
999541020749	tetramer interface [polypeptide binding]; other site
999541020750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541020751	catalytic residue [active]
999541020752	Protein of unknown function (DUF779); Region: DUF779; pfam05610
999541020753	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541020754	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
999541020755	Transcriptional regulators [Transcription]; Region: MarR; COG1846
999541020756	MarR family; Region: MarR_2; pfam12802
999541020757	putative acyltransferase; Provisional; Region: PRK05790
999541020758	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
999541020759	dimer interface [polypeptide binding]; other site
999541020760	active site
999541020761	Predicted transcriptional regulators [Transcription]; Region: COG1733
999541020762	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
999541020763	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
999541020764	argininosuccinate synthase; Validated; Region: PRK05370
999541020765	argininosuccinate synthase; Provisional; Region: PRK13820
999541020766	imidazole glycerol phosphate synthase hisHF; Region: PLN02617
999541020767	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541020768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020769	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541020770	putative effector binding pocket; other site
999541020771	dimerization interface [polypeptide binding]; other site
999541020772	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541020773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541020774	active site
999541020775	phosphorylation site [posttranslational modification]
999541020776	intermolecular recognition site; other site
999541020777	dimerization interface [polypeptide binding]; other site
999541020778	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541020779	DNA binding site [nucleotide binding]
999541020780	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
999541020781	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
999541020782	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
999541020783	HlyD family secretion protein; Region: HlyD_3; pfam13437
999541020784	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
999541020785	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541020786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020787	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541020788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541020789	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
999541020790	classical (c) SDRs; Region: SDR_c; cd05233
999541020791	NAD(P) binding site [chemical binding]; other site
999541020792	active site
999541020793	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541020794	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541020795	trimer interface [polypeptide binding]; other site
999541020796	eyelet of channel; other site
999541020797	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541020798	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541020799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
999541020800	active site
999541020801	phosphorylation site [posttranslational modification]
999541020802	intermolecular recognition site; other site
999541020803	dimerization interface [polypeptide binding]; other site
999541020804	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541020805	DNA binding site [nucleotide binding]
999541020806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541020807	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541020808	dimerization interface [polypeptide binding]; other site
999541020809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541020810	ATP binding site [chemical binding]; other site
999541020811	Mg2+ binding site [ion binding]; other site
999541020812	G-X-G motif; other site
999541020813	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541020814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541020815	active site
999541020816	phosphorylation site [posttranslational modification]
999541020817	intermolecular recognition site; other site
999541020818	dimerization interface [polypeptide binding]; other site
999541020819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
999541020820	DNA binding site [nucleotide binding]
999541020821	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541020822	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
999541020823	glutathione reductase; Validated; Region: PRK06116
999541020824	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
999541020825	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
999541020826	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
999541020827	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
999541020828	trimer interface [polypeptide binding]; other site
999541020829	eyelet of channel; other site
999541020830	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
999541020831	dimer interface [polypeptide binding]; other site
999541020832	ligand binding site [chemical binding]; other site
999541020833	Chromate transporter; Region: Chromate_transp; pfam02417
999541020834	Chromate transporter; Region: Chromate_transp; pfam02417
999541020835	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541020836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541020837	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
999541020838	dimerization interface [polypeptide binding]; other site
999541020839	substrate binding pocket [chemical binding]; other site
999541020840	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
999541020841	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
999541020842	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
999541020843	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
999541020844	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
999541020845	Flagellar regulator YcgR; Region: YcgR; pfam07317
999541020846	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
999541020847	PilZ domain; Region: PilZ; pfam07238
999541020848	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
999541020849	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
999541020850	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
999541020851	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
999541020852	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697
999541020853	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
999541020854	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
999541020855	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
999541020856	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
999541020857	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
999541020858	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
999541020859	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
999541020860	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
999541020861	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
999541020862	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
999541020863	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
999541020864	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
999541020865	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
999541020866	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
999541020867	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
999541020868	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
999541020869	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
999541020870	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626
999541020871	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
999541020872	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
999541020873	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
999541020874	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
999541020875	FlgN protein; Region: FlgN; pfam05130
999541020876	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
999541020877	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
999541020878	active site
999541020879	NTP binding site [chemical binding]; other site
999541020880	metal binding triad [ion binding]; metal-binding site
999541020881	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
999541020882	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
999541020883	Zn2+ binding site [ion binding]; other site
999541020884	Mg2+ binding site [ion binding]; other site
999541020885	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
999541020886	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
999541020887	putative NAD(P) binding site [chemical binding]; other site
999541020888	active site
999541020889	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541020890	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541020891	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541020892	catalytic residue [active]
999541020893	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
999541020894	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
999541020895	MarR family; Region: MarR_2; cl17246
999541020896	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541020897	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
999541020898	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
999541020899	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
999541020900	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
999541020901	putative active site [active]
999541020902	TraB family; Region: TraB; pfam01963
999541020903	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
999541020904	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541020905	Walker A/P-loop; other site
999541020906	ATP binding site [chemical binding]; other site
999541020907	Q-loop/lid; other site
999541020908	ABC transporter signature motif; other site
999541020909	Walker B; other site
999541020910	D-loop; other site
999541020911	H-loop/switch region; other site
999541020912	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
999541020913	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
999541020914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
999541020915	Walker A/P-loop; other site
999541020916	ATP binding site [chemical binding]; other site
999541020917	Q-loop/lid; other site
999541020918	ABC transporter signature motif; other site
999541020919	Walker B; other site
999541020920	D-loop; other site
999541020921	H-loop/switch region; other site
999541020922	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
999541020923	dipeptide transporter; Provisional; Region: PRK10913
999541020924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541020925	dimer interface [polypeptide binding]; other site
999541020926	conserved gate region; other site
999541020927	putative PBP binding loops; other site
999541020928	ABC-ATPase subunit interface; other site
999541020929	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
999541020930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541020931	dimer interface [polypeptide binding]; other site
999541020932	conserved gate region; other site
999541020933	putative PBP binding loops; other site
999541020934	ABC-ATPase subunit interface; other site
999541020935	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
999541020936	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
999541020937	peptide binding site [polypeptide binding]; other site
999541020938	citrate-proton symporter; Provisional; Region: PRK15075
999541020939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541020940	putative substrate translocation pore; other site
999541020941	High potential iron-sulfur protein; Region: HIPIP; pfam01355
999541020942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541020943	Walker A motif; other site
999541020944	ATP binding site [chemical binding]; other site
999541020945	Walker B motif; other site
999541020946	arginine finger; other site
999541020947	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
999541020948	putative catalytic site [active]
999541020949	putative phosphate binding site [ion binding]; other site
999541020950	putative metal binding site [ion binding]; other site
999541020951	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
999541020952	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
999541020953	FAD binding pocket [chemical binding]; other site
999541020954	FAD binding motif [chemical binding]; other site
999541020955	phosphate binding motif [ion binding]; other site
999541020956	beta-alpha-beta structure motif; other site
999541020957	NAD binding pocket [chemical binding]; other site
999541020958	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541020959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541020960	active site
999541020961	phosphorylation site [posttranslational modification]
999541020962	intermolecular recognition site; other site
999541020963	dimerization interface [polypeptide binding]; other site
999541020964	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541020965	DNA binding residues [nucleotide binding]
999541020966	dimerization interface [polypeptide binding]; other site
999541020967	amino acid transporter; Region: 2A0306; TIGR00909
999541020968	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
999541020969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
999541020970	Rhomboid family; Region: Rhomboid; pfam01694
999541020971	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
999541020972	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
999541020973	Flagellar protein FliT; Region: FliT; pfam05400
999541020974	Flagellar protein FliS; Region: FliS; cl00654
999541020975	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
999541020976	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
999541020977	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
999541020978	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
999541020979	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
999541020980	FliG C-terminal domain; Region: FliG_C; pfam01706
999541020981	flagellar assembly protein H; Validated; Region: fliH; PRK05687
999541020982	Flagellar assembly protein FliH; Region: FliH; pfam02108
999541020983	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
999541020984	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
999541020985	Walker A motif/ATP binding site; other site
999541020986	Walker B motif; other site
999541020987	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
999541020988	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
999541020989	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
999541020990	choline dehydrogenase; Validated; Region: PRK02106
999541020991	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541020992	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541020993	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541020994	active site
999541020995	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
999541020996	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
999541020997	NAD(P) binding site [chemical binding]; other site
999541020998	catalytic residues [active]
999541020999	serine/threonine protein kinase; Provisional; Region: PRK11768
999541021000	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
999541021001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541021002	putative substrate translocation pore; other site
999541021003	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541021004	EamA-like transporter family; Region: EamA; pfam00892
999541021005	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
999541021006	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
999541021007	active site
999541021008	catalytic tetrad [active]
999541021009	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
999541021010	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
999541021011	S-adenosylmethionine synthetase; Validated; Region: PRK05250
999541021012	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
999541021013	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
999541021014	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
999541021015	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
999541021016	putative acyl-acceptor binding pocket; other site
999541021017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541021018	non-specific DNA binding site [nucleotide binding]; other site
999541021019	salt bridge; other site
999541021020	sequence-specific DNA binding site [nucleotide binding]; other site
999541021021	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
999541021022	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
999541021023	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
999541021024	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
999541021025	Protein of unknown function, DUF484; Region: DUF484; cl17449
999541021026	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
999541021027	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541021028	active site
999541021029	DNA binding site [nucleotide binding]
999541021030	Int/Topo IB signature motif; other site
999541021031	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
999541021032	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
999541021033	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
999541021034	putative RNA binding site [nucleotide binding]; other site
999541021035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021036	S-adenosylmethionine binding site [chemical binding]; other site
999541021037	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
999541021038	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
999541021039	P-loop, Walker A motif; other site
999541021040	Base recognition motif; other site
999541021041	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
999541021042	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
999541021043	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
999541021044	active site
999541021045	HslU subunit interaction site [polypeptide binding]; other site
999541021046	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
999541021047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541021048	Walker A motif; other site
999541021049	ATP binding site [chemical binding]; other site
999541021050	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
999541021051	Walker B motif; other site
999541021052	arginine finger; other site
999541021053	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
999541021054	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
999541021055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541021056	active site
999541021057	phosphorylation site [posttranslational modification]
999541021058	intermolecular recognition site; other site
999541021059	dimerization interface [polypeptide binding]; other site
999541021060	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541021061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541021062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541021063	dimer interface [polypeptide binding]; other site
999541021064	phosphorylation site [posttranslational modification]
999541021065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541021066	ATP binding site [chemical binding]; other site
999541021067	Mg2+ binding site [ion binding]; other site
999541021068	G-X-G motif; other site
999541021069	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
999541021070	feedback inhibition sensing region; other site
999541021071	homohexameric interface [polypeptide binding]; other site
999541021072	nucleotide binding site [chemical binding]; other site
999541021073	N-acetyl-L-glutamate binding site [chemical binding]; other site
999541021074	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
999541021075	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
999541021076	motif II; other site
999541021077	division inhibitor protein; Provisional; Region: slmA; PRK09480
999541021078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541021079	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
999541021080	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
999541021081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021082	S-adenosylmethionine binding site [chemical binding]; other site
999541021083	muropeptide transporter; Reviewed; Region: ampG; PRK11902
999541021084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541021085	putative substrate translocation pore; other site
999541021086	Peptidase family M48; Region: Peptidase_M48; cl12018
999541021087	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
999541021088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541021089	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541021090	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541021091	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
999541021092	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
999541021093	putative NAD(P) binding site [chemical binding]; other site
999541021094	putative substrate binding site [chemical binding]; other site
999541021095	catalytic Zn binding site [ion binding]; other site
999541021096	structural Zn binding site [ion binding]; other site
999541021097	dimer interface [polypeptide binding]; other site
999541021098	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
999541021099	putative active site [active]
999541021100	putative catalytic site [active]
999541021101	putative DNA binding site [nucleotide binding]; other site
999541021102	putative phosphate binding site [ion binding]; other site
999541021103	metal binding site A [ion binding]; metal-binding site
999541021104	putative AP binding site [nucleotide binding]; other site
999541021105	putative metal binding site B [ion binding]; other site
999541021106	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
999541021107	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
999541021108	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
999541021109	GatB domain; Region: GatB_Yqey; smart00845
999541021110	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
999541021111	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
999541021112	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
999541021113	rod shape-determining protein MreB; Provisional; Region: PRK13927
999541021114	MreB and similar proteins; Region: MreB_like; cd10225
999541021115	nucleotide binding site [chemical binding]; other site
999541021116	Mg binding site [ion binding]; other site
999541021117	putative protofilament interaction site [polypeptide binding]; other site
999541021118	RodZ interaction site [polypeptide binding]; other site
999541021119	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
999541021120	rod shape-determining protein MreC; Region: MreC; pfam04085
999541021121	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
999541021122	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
999541021123	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
999541021124	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
999541021125	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
999541021126	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541021127	Sel1-like repeats; Region: SEL1; smart00671
999541021128	Sel1-like repeats; Region: SEL1; smart00671
999541021129	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
999541021130	active site
999541021131	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
999541021132	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
999541021133	FeS/SAM binding site; other site
999541021134	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
999541021135	Ligand Binding Site [chemical binding]; other site
999541021136	Response regulator receiver domain; Region: Response_reg; pfam00072
999541021137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541021138	active site
999541021139	phosphorylation site [posttranslational modification]
999541021140	intermolecular recognition site; other site
999541021141	dimerization interface [polypeptide binding]; other site
999541021142	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541021143	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
999541021144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541021145	dimerization interface [polypeptide binding]; other site
999541021146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541021147	dimer interface [polypeptide binding]; other site
999541021148	phosphorylation site [posttranslational modification]
999541021149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541021150	ATP binding site [chemical binding]; other site
999541021151	Mg2+ binding site [ion binding]; other site
999541021152	G-X-G motif; other site
999541021153	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
999541021154	16S rRNA methyltransferase B; Provisional; Region: PRK10901
999541021155	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
999541021156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021157	S-adenosylmethionine binding site [chemical binding]; other site
999541021158	MltA-interacting protein MipA; Region: MipA; cl01504
999541021159	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
999541021160	Predicted transcriptional regulator [Transcription]; Region: COG3905
999541021161	M48 family peptidase; Provisional; Region: PRK03001
999541021162	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
999541021163	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
999541021164	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
999541021165	putative active site [active]
999541021166	substrate binding site [chemical binding]; other site
999541021167	putative cosubstrate binding site; other site
999541021168	catalytic site [active]
999541021169	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
999541021170	substrate binding site [chemical binding]; other site
999541021171	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
999541021172	active site
999541021173	catalytic residues [active]
999541021174	metal binding site [ion binding]; metal-binding site
999541021175	DNA protecting protein DprA; Region: dprA; TIGR00732
999541021176	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
999541021177	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
999541021178	catalytic residues [active]
999541021179	DNA topoisomerase III; Validated; Region: PRK08173
999541021180	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
999541021181	active site
999541021182	putative interdomain interaction site [polypeptide binding]; other site
999541021183	putative metal-binding site [ion binding]; other site
999541021184	putative nucleotide binding site [chemical binding]; other site
999541021185	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
999541021186	domain I; other site
999541021187	DNA binding groove [nucleotide binding]
999541021188	phosphate binding site [ion binding]; other site
999541021189	domain II; other site
999541021190	domain III; other site
999541021191	nucleotide binding site [chemical binding]; other site
999541021192	catalytic site [active]
999541021193	domain IV; other site
999541021194	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
999541021195	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
999541021196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541021197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541021198	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541021199	putative effector binding pocket; other site
999541021200	dimerization interface [polypeptide binding]; other site
999541021201	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
999541021202	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
999541021203	dimerization interface [polypeptide binding]; other site
999541021204	NAD binding site [chemical binding]; other site
999541021205	ligand binding site [chemical binding]; other site
999541021206	catalytic site [active]
999541021207	Patatin-like phospholipase; Region: Patatin; pfam01734
999541021208	active site
999541021209	nucleophile elbow; other site
999541021210	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541021211	CoenzymeA binding site [chemical binding]; other site
999541021212	subunit interaction site [polypeptide binding]; other site
999541021213	PHB binding site; other site
999541021214	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
999541021215	putative active site [active]
999541021216	catalytic site [active]
999541021217	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
999541021218	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541021219	ATP binding site [chemical binding]; other site
999541021220	putative Mg++ binding site [ion binding]; other site
999541021221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
999541021222	nucleotide binding region [chemical binding]; other site
999541021223	ATP-binding site [chemical binding]; other site
999541021224	Protein of unknown function DUF262; Region: DUF262; pfam03235
999541021225	Uncharacterized conserved protein [Function unknown]; Region: COG1479
999541021226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021227	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021228	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021229	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
999541021230	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
999541021231	DNA methylase; Region: N6_N4_Mtase; pfam01555
999541021232	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541021233	MULE transposase domain; Region: MULE; pfam10551
999541021234	Restriction endonuclease [Defense mechanisms]; Region: COG3587
999541021235	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
999541021236	ATP binding site [chemical binding]; other site
999541021237	putative Mg++ binding site [ion binding]; other site
999541021238	glutamate--cysteine ligase; Provisional; Region: PRK02107
999541021239	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
999541021240	AlkA N-terminal domain; Region: AlkA_N; pfam06029
999541021241	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
999541021242	minor groove reading motif; other site
999541021243	helix-hairpin-helix signature motif; other site
999541021244	substrate binding pocket [chemical binding]; other site
999541021245	active site
999541021246	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
999541021247	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
999541021248	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541021249	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
999541021250	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
999541021251	DNA binding site [nucleotide binding]
999541021252	active site
999541021253	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
999541021254	dimer interface [polypeptide binding]; other site
999541021255	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541021256	metal binding site [ion binding]; metal-binding site
999541021257	YaeQ protein; Region: YaeQ; pfam07152
999541021258	Cupin domain; Region: Cupin_2; cl17218
999541021259	Cupin domain; Region: Cupin_2; cl17218
999541021260	Transcriptional regulator [Transcription]; Region: LysR; COG0583
999541021261	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541021262	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
999541021263	putative effector binding pocket; other site
999541021264	dimerization interface [polypeptide binding]; other site
999541021265	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
999541021266	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
999541021267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021268	S-adenosylmethionine binding site [chemical binding]; other site
999541021269	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
999541021270	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
999541021271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
999541021272	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
999541021273	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
999541021274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021275	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
999541021276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
999541021277	Anti-sigma-K factor rskA; Region: RskA; pfam10099
999541021278	RNA polymerase sigma factor; Provisional; Region: PRK12514
999541021279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
999541021280	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
999541021281	DNA binding residues [nucleotide binding]
999541021282	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
999541021283	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
999541021284	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
999541021285	trmE is a tRNA modification GTPase; Region: trmE; cd04164
999541021286	G1 box; other site
999541021287	GTP/Mg2+ binding site [chemical binding]; other site
999541021288	Switch I region; other site
999541021289	G2 box; other site
999541021290	Switch II region; other site
999541021291	G3 box; other site
999541021292	G4 box; other site
999541021293	G5 box; other site
999541021294	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
999541021295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
999541021296	sequence-specific DNA binding site [nucleotide binding]; other site
999541021297	salt bridge; other site
999541021298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541021299	sequence-specific DNA binding site [nucleotide binding]; other site
999541021300	salt bridge; other site
999541021301	membrane protein insertase; Provisional; Region: PRK01318
999541021302	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
999541021303	hypothetical protein; Validated; Region: PRK00041
999541021304	Ribonuclease P; Region: Ribonuclease_P; cl00457
999541021305	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
999541021306	ParA-like protein; Provisional; Region: PHA02518
999541021307	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541021308	P-loop; other site
999541021309	Magnesium ion binding site [ion binding]; other site
999541021310	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
999541021311	ParB-like nuclease domain; Region: ParBc; pfam02195
999541021312	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
999541021313	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
999541021314	Haemagglutinin; Region: HIM; pfam05662
999541021315	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021316	trimer interface [polypeptide binding]; other site
999541021317	YadA-like C-terminal region; Region: YadA; pfam03895
999541021318	DDE domain; Region: DDE_Tnp_IS240; pfam13610
999541021319	Integrase core domain; Region: rve; pfam00665
999541021320	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
999541021321	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021322	trimer interface [polypeptide binding]; other site
999541021323	YadA-like C-terminal region; Region: YadA; pfam03895
999541021324	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
999541021325	short chain dehydrogenase; Provisional; Region: PRK06172
999541021326	classical (c) SDRs; Region: SDR_c; cd05233
999541021327	NAD(P) binding site [chemical binding]; other site
999541021328	active site
999541021329	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
999541021330	H-NS histone family; Region: Histone_HNS; pfam00816
999541021331	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
999541021332	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021333	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541021334	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
999541021335	PapC N-terminal domain; Region: PapC_N; pfam13954
999541021336	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
999541021337	PapC C-terminal domain; Region: PapC_C; pfam13953
999541021338	putative chaperone protein EcpD; Provisional; Region: PRK09926
999541021339	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
999541021340	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
999541021341	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
999541021342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541021343	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541021344	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541021345	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541021346	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541021347	PAAR motif; Region: PAAR_motif; pfam05488
999541021348	TrwC relaxase; Region: TrwC; pfam08751
999541021349	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
999541021350	AAA domain; Region: AAA_30; pfam13604
999541021351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021352	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021353	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021354	F sex factor protein N terminal; Region: TraD_N; pfam12615
999541021355	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541021356	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
999541021357	Walker A motif; other site
999541021358	ATP binding site [chemical binding]; other site
999541021359	Walker B motif; other site
999541021360	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
999541021361	ParB-like nuclease domain; Region: ParB; smart00470
999541021362	DNA methylase; Region: N6_N4_Mtase; cl17433
999541021363	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
999541021364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021365	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021366	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021367	Domain of unknown function (DUF932); Region: DUF932; pfam06067
999541021368	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
999541021369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541021370	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
999541021371	Walker A motif; other site
999541021372	ATP binding site [chemical binding]; other site
999541021373	Walker B motif; other site
999541021374	arginine finger; other site
999541021375	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021377	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021378	HTH-like domain; Region: HTH_21; pfam13276
999541021379	Integrase core domain; Region: rve; pfam00665
999541021380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021381	Transposase; Region: HTH_Tnp_1; pfam01527
999541021382	AAA domain; Region: AAA_33; pfam13671
999541021383	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
999541021384	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
999541021385	putative active site [active]
999541021386	putative metal-binding site [ion binding]; other site
999541021387	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
999541021388	FAD binding domain; Region: FAD_binding_4; pfam01565
999541021389	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
999541021390	Berberine and berberine like; Region: BBE; pfam08031
999541021391	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541021392	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
999541021393	DNA binding residues [nucleotide binding]
999541021394	dimerization interface [polypeptide binding]; other site
999541021395	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541021396	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
999541021397	Cytochrome P450; Region: p450; cl12078
999541021398	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541021399	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541021400	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541021401	active site
999541021402	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
999541021403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021404	S-adenosylmethionine binding site [chemical binding]; other site
999541021405	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541021406	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541021407	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021408	Di-iron ligands [ion binding]; other site
999541021409	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021410	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541021411	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021412	Di-iron ligands [ion binding]; other site
999541021413	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021414	acyl-CoA synthetase; Validated; Region: PRK05850
999541021415	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541021416	acyl-activating enzyme (AAE) consensus motif; other site
999541021417	active site
999541021418	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541021419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
999541021420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
999541021421	metal binding site [ion binding]; metal-binding site
999541021422	active site
999541021423	I-site; other site
999541021424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
999541021425	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
999541021426	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
999541021427	FtsX-like permease family; Region: FtsX; pfam02687
999541021428	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
999541021429	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
999541021430	Walker A/P-loop; other site
999541021431	ATP binding site [chemical binding]; other site
999541021432	Q-loop/lid; other site
999541021433	ABC transporter signature motif; other site
999541021434	Walker B; other site
999541021435	D-loop; other site
999541021436	H-loop/switch region; other site
999541021437	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
999541021438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541021439	active site
999541021440	phosphorylation site [posttranslational modification]
999541021441	intermolecular recognition site; other site
999541021442	dimerization interface [polypeptide binding]; other site
999541021443	LytTr DNA-binding domain; Region: LytTR; smart00850
999541021444	Histidine kinase; Region: His_kinase; pfam06580
999541021445	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
999541021446	Mg2+ binding site [ion binding]; other site
999541021447	ParB-like nuclease domain; Region: ParBc; cl02129
999541021448	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
999541021449	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541021450	catalytic residue [active]
999541021451	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
999541021452	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
999541021453	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
999541021454	catalytic residue [active]
999541021455	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541021456	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541021457	active site
999541021458	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021459	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
999541021460	dinuclear metal binding motif [ion binding]; other site
999541021461	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
999541021462	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541021463	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
999541021464	catalytic site [active]
999541021465	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
999541021466	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
999541021467	Walker A/P-loop; other site
999541021468	ATP binding site [chemical binding]; other site
999541021469	Q-loop/lid; other site
999541021470	ABC transporter signature motif; other site
999541021471	Walker B; other site
999541021472	D-loop; other site
999541021473	H-loop/switch region; other site
999541021474	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541021475	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541021476	active site
999541021477	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
999541021478	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
999541021479	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541021480	putative NADP binding site [chemical binding]; other site
999541021481	active site
999541021482	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021483	Condensation domain; Region: Condensation; pfam00668
999541021484	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541021485	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541021486	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541021487	acyl-activating enzyme (AAE) consensus motif; other site
999541021488	AMP binding site [chemical binding]; other site
999541021489	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
999541021490	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541021491	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541021492	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541021493	acyl-activating enzyme (AAE) consensus motif; other site
999541021494	AMP binding site [chemical binding]; other site
999541021495	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021496	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
999541021497	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
999541021498	MbtH-like protein; Region: MbtH; cl01279
999541021499	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
999541021500	Sel1-like repeats; Region: SEL1; smart00671
999541021501	H-NS histone family; Region: Histone_HNS; pfam00816
999541021502	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021503	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
999541021504	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
999541021505	DNA binding site [nucleotide binding]
999541021506	active site
999541021507	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
999541021508	DNA binding site [nucleotide binding]
999541021509	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
999541021510	nucleotide binding site [chemical binding]; other site
999541021511	H-NS histone family; Region: Histone_HNS; pfam00816
999541021512	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021513	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
999541021514	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
999541021515	active site
999541021516	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
999541021517	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
999541021518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541021519	HTH-like domain; Region: HTH_21; pfam13276
999541021520	Integrase core domain; Region: rve; pfam00665
999541021521	Integrase core domain; Region: rve_3; pfam13683
999541021522	Transposase; Region: HTH_Tnp_1; pfam01527
999541021523	Cache domain; Region: Cache_1; pfam02743
999541021524	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
999541021525	dimerization interface [polypeptide binding]; other site
999541021526	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
999541021527	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541021528	dimer interface [polypeptide binding]; other site
999541021529	putative CheW interface [polypeptide binding]; other site
999541021530	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
999541021531	DNA-binding interface [nucleotide binding]; DNA binding site
999541021532	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541021533	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541021534	dimer interface [polypeptide binding]; other site
999541021535	putative CheW interface [polypeptide binding]; other site
999541021536	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
999541021537	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
999541021538	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
999541021539	dimer interface [polypeptide binding]; other site
999541021540	putative CheW interface [polypeptide binding]; other site
999541021541	RES domain; Region: RES; cl02411
999541021542	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
999541021543	Transposase; Region: HTH_Tnp_1; pfam01527
999541021544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021546	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021547	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021548	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
999541021549	LabA_like proteins; Region: LabA_like/DUF88; cl10034
999541021550	putative metal binding site [ion binding]; other site
999541021551	H-NS histone family; Region: Histone_HNS; pfam00816
999541021552	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021553	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
999541021554	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
999541021555	multidrug efflux protein; Reviewed; Region: PRK01766
999541021556	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
999541021557	cation binding site [ion binding]; other site
999541021558	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
999541021559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541021560	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
999541021561	Antirestriction protein; Region: Antirestrict; pfam03230
999541021562	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
999541021563	PAAR motif; Region: PAAR_motif; pfam05488
999541021564	H-NS histone family; Region: Histone_HNS; pfam00816
999541021565	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021566	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
999541021567	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
999541021568	active site
999541021569	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
999541021570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541021571	Coenzyme A binding pocket [chemical binding]; other site
999541021572	Transposase, Mutator family; Region: Transposase_mut; pfam00872
999541021573	MULE transposase domain; Region: MULE; pfam10551
999541021574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541021575	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541021576	Walker A motif; other site
999541021577	ATP binding site [chemical binding]; other site
999541021578	Walker B motif; other site
999541021579	arginine finger; other site
999541021580	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
999541021581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
999541021582	active site
999541021583	phosphorylation site [posttranslational modification]
999541021584	intermolecular recognition site; other site
999541021585	dimerization interface [polypeptide binding]; other site
999541021586	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
999541021587	DNA binding site [nucleotide binding]
999541021588	CHASE2 domain; Region: CHASE2; pfam05226
999541021589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541021590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
999541021591	dimer interface [polypeptide binding]; other site
999541021592	phosphorylation site [posttranslational modification]
999541021593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541021594	ATP binding site [chemical binding]; other site
999541021595	Mg2+ binding site [ion binding]; other site
999541021596	G-X-G motif; other site
999541021597	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
999541021598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
999541021599	active site
999541021600	phosphorylation site [posttranslational modification]
999541021601	intermolecular recognition site; other site
999541021602	dimerization interface [polypeptide binding]; other site
999541021603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541021604	DNA binding residues [nucleotide binding]
999541021605	dimerization interface [polypeptide binding]; other site
999541021606	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
999541021607	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021608	trimer interface [polypeptide binding]; other site
999541021609	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021610	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021611	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
999541021612	trimer interface [polypeptide binding]; other site
999541021613	YadA-like C-terminal region; Region: YadA; pfam03895
999541021614	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
999541021615	catalytic residues [active]
999541021616	hinge region; other site
999541021617	alpha helical domain; other site
999541021618	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
999541021619	PapC N-terminal domain; Region: PapC_N; pfam13954
999541021620	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
999541021621	putative fimbrial chaperone protein; Provisional; Region: PRK09918
999541021622	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
999541021623	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
999541021624	H-NS histone family; Region: Histone_HNS; pfam00816
999541021625	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021626	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
999541021627	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541021628	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
999541021629	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
999541021630	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
999541021631	ParB-like nuclease domain; Region: ParBc; cl02129
999541021632	O-methyltransferase; Region: Methyltransf_2; pfam00891
999541021633	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
999541021634	multidrug efflux protein; Reviewed; Region: PRK01766
999541021635	cation binding site [ion binding]; other site
999541021636	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
999541021637	hydrophobic ligand binding site; other site
999541021638	Condensation domain; Region: Condensation; pfam00668
999541021639	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541021640	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541021641	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541021642	acyl-activating enzyme (AAE) consensus motif; other site
999541021643	AMP binding site [chemical binding]; other site
999541021644	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541021645	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021646	Condensation domain; Region: Condensation; pfam00668
999541021647	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541021648	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541021649	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541021650	acyl-activating enzyme (AAE) consensus motif; other site
999541021651	AMP binding site [chemical binding]; other site
999541021652	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021653	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
999541021654	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
999541021655	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
999541021656	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
999541021657	dimer interface [polypeptide binding]; other site
999541021658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
999541021659	catalytic residue [active]
999541021660	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541021661	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541021662	active site
999541021663	Acyl transferase domain; Region: Acyl_transf_1; cl08282
999541021664	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021665	Condensation domain; Region: Condensation; pfam00668
999541021666	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541021667	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541021668	acyl-activating enzyme (AAE) consensus motif; other site
999541021669	AMP binding site [chemical binding]; other site
999541021670	active site
999541021671	CoA binding site [chemical binding]; other site
999541021672	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021673	Condensation domain; Region: Condensation; pfam00668
999541021674	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
999541021675	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
999541021676	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541021677	acyl-activating enzyme (AAE) consensus motif; other site
999541021678	AMP binding site [chemical binding]; other site
999541021679	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021680	Condensation domain; Region: Condensation; pfam00668
999541021681	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
999541021682	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
999541021683	acyl-activating enzyme (AAE) consensus motif; other site
999541021684	AMP binding site [chemical binding]; other site
999541021685	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541021686	Cytochrome P450; Region: p450; cl12078
999541021687	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
999541021688	Amidase; Region: Amidase; cl11426
999541021689	Autoinducer synthetase; Region: Autoind_synth; cl17404
999541021690	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
999541021691	Autoinducer binding domain; Region: Autoind_bind; pfam03472
999541021692	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
999541021693	DNA binding residues [nucleotide binding]
999541021694	dimerization interface [polypeptide binding]; other site
999541021695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
999541021696	HTH-like domain; Region: HTH_21; pfam13276
999541021697	Integrase core domain; Region: rve; pfam00665
999541021698	Integrase core domain; Region: rve_3; pfam13683
999541021699	Transposase; Region: HTH_Tnp_1; pfam01527
999541021700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021701	putative transposase OrfB; Reviewed; Region: PHA02517
999541021702	Integrase core domain; Region: rve; pfam00665
999541021703	Integrase core domain; Region: rve_3; pfam13683
999541021704	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
999541021705	oligomeric interface; other site
999541021706	putative active site [active]
999541021707	homodimer interface [polypeptide binding]; other site
999541021708	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
999541021709	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
999541021710	oligomeric interface; other site
999541021711	putative active site [active]
999541021712	homodimer interface [polypeptide binding]; other site
999541021713	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
999541021714	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
999541021715	active site
999541021716	Int/Topo IB signature motif; other site
999541021717	catalytic residues [active]
999541021718	DNA binding site [nucleotide binding]
999541021719	Phage integrase protein; Region: DUF3701; pfam12482
999541021720	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
999541021721	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541021722	active site
999541021723	DNA binding site [nucleotide binding]
999541021724	Int/Topo IB signature motif; other site
999541021725	H-NS histone family; Region: Histone_HNS; pfam00816
999541021726	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021727	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
999541021728	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
999541021729	active site
999541021730	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
999541021731	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
999541021732	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
999541021733	choline dehydrogenase; Validated; Region: PRK02106
999541021734	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
999541021735	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
999541021736	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
999541021737	NAD(P) binding site [chemical binding]; other site
999541021738	catalytic residues [active]
999541021739	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
999541021740	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541021741	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541021742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021744	Helix-turn-helix domain; Region: HTH_28; pfam13518
999541021745	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541021746	putative transposase OrfB; Reviewed; Region: PHA02517
999541021747	HTH-like domain; Region: HTH_21; pfam13276
999541021748	Integrase core domain; Region: rve; pfam00665
999541021749	Integrase core domain; Region: rve_2; pfam13333
999541021750	H-NS histone family; Region: Histone_HNS; pfam00816
999541021751	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021752	MarR family; Region: MarR_2; cl17246
999541021753	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541021754	Phage integrase protein; Region: DUF3701; pfam12482
999541021755	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541021756	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
999541021757	active site
999541021758	DNA binding site [nucleotide binding]
999541021759	Int/Topo IB signature motif; other site
999541021760	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
999541021761	oligomeric interface; other site
999541021762	putative active site [active]
999541021763	homodimer interface [polypeptide binding]; other site
999541021764	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
999541021765	ParA-like protein; Provisional; Region: PHA02518
999541021766	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
999541021767	P-loop; other site
999541021768	Magnesium ion binding site [ion binding]; other site
999541021769	ParB-like nuclease domain; Region: ParB; smart00470
999541021770	Initiator Replication protein; Region: Rep_3; pfam01051
999541021771	VirB8 protein; Region: VirB8; pfam04335
999541021772	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
999541021773	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
999541021774	VirB7 interaction site; other site
999541021775	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
999541021776	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
999541021777	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
999541021778	VirB7 interaction site; other site
999541021779	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
999541021780	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
999541021781	N-acetyl-D-glucosamine binding site [chemical binding]; other site
999541021782	catalytic residue [active]
999541021783	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
999541021784	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
999541021785	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
999541021786	Type II/IV secretion system protein; Region: T2SE; pfam00437
999541021787	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
999541021788	Walker A motif; other site
999541021789	ATP binding site [chemical binding]; other site
999541021790	Walker B motif; other site
999541021791	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
999541021792	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
999541021793	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
999541021794	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
999541021795	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021796	putative transposase OrfB; Reviewed; Region: PHA02517
999541021797	Integrase core domain; Region: rve; pfam00665
999541021798	Integrase core domain; Region: rve_3; pfam13683
999541021799	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
999541021800	Nuclease-related domain; Region: NERD; pfam08378
999541021801	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
999541021802	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
999541021803	dimer interface [polypeptide binding]; other site
999541021804	ssDNA binding site [nucleotide binding]; other site
999541021805	tetramer (dimer of dimers) interface [polypeptide binding]; other site
999541021806	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533
999541021807	Toprim domain; Region: Toprim_3; pfam13362
999541021808	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
999541021809	PRTRC system protein D; Region: PRTRC_D; TIGR03739
999541021810	Mg binding site [ion binding]; other site
999541021811	nucleotide binding site [chemical binding]; other site
999541021812	putative protofilament interface [polypeptide binding]; other site
999541021813	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
999541021814	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
999541021815	active site
999541021816	catalytic residues [active]
999541021817	Int/Topo IB signature motif; other site
999541021818	DNA binding site [nucleotide binding]
999541021819	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
999541021820	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
999541021821	ParB-like nuclease domain; Region: ParBc; pfam02195
999541021822	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
999541021823	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
999541021824	PRTRC system protein E; Region: PRTRC_E; TIGR03741
999541021825	PRTRC system protein C; Region: PRTRC_C; TIGR03738
999541021826	PRTRC system protein F; Region: PRTRC_F; TIGR03742
999541021827	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
999541021828	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
999541021829	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
999541021830	PRTRC system protein A; Region: PRTRC_A; TIGR03735
999541021831	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
999541021832	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
999541021833	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
999541021834	ATP binding site [chemical binding]; other site
999541021835	substrate interface [chemical binding]; other site
999541021836	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
999541021837	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
999541021838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541021839	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
999541021840	Walker A motif; other site
999541021841	ATP binding site [chemical binding]; other site
999541021842	Walker B motif; other site
999541021843	arginine finger; other site
999541021844	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
999541021845	beta-clamp/clamp loader binding surface; other site
999541021846	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
999541021847	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
999541021848	metal ion-dependent adhesion site (MIDAS); other site
999541021849	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
999541021850	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
999541021851	Walker A motif; other site
999541021852	hexamer interface [polypeptide binding]; other site
999541021853	ATP binding site [chemical binding]; other site
999541021854	Walker B motif; other site
999541021855	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
999541021856	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
999541021857	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
999541021858	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
999541021859	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
999541021860	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
999541021861	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
999541021862	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
999541021863	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
999541021864	Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527
999541021865	Domain of unknown function (DUF4400); Region: DUF4400; pfam14348
999541021866	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
999541021867	Family description; Region: UvrD_C_2; pfam13538
999541021868	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
999541021869	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
999541021870	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
999541021871	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
999541021872	active site
999541021873	metal binding site [ion binding]; metal-binding site
999541021874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541021875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541021876	Walker A/P-loop; other site
999541021877	Walker A/P-loop; other site
999541021878	ATP binding site [chemical binding]; other site
999541021879	ATP binding site [chemical binding]; other site
999541021880	Q-loop/lid; other site
999541021881	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
999541021882	PLD-like domain; Region: PLDc_2; pfam13091
999541021883	putative active site [active]
999541021884	catalytic site [active]
999541021885	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
999541021886	Ligand Binding Site [chemical binding]; other site
999541021887	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
999541021888	active site
999541021889	Int/Topo IB signature motif; other site
999541021890	catalytic residues [active]
999541021891	DNA binding site [nucleotide binding]
999541021892	H-NS histone family; Region: Histone_HNS; pfam00816
999541021893	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021894	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
999541021895	DNA-binding interface [nucleotide binding]; DNA binding site
999541021896	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
999541021897	Phage integrase protein; Region: DUF3701; pfam12482
999541021898	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
999541021899	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
999541021900	Int/Topo IB signature motif; other site
999541021901	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
999541021902	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
999541021903	phosphate binding site [ion binding]; other site
999541021904	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541021905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541021906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541021907	dimerization interface [polypeptide binding]; other site
999541021908	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
999541021909	Phage integrase protein; Region: DUF3701; pfam12482
999541021910	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541021911	active site
999541021912	DNA binding site [nucleotide binding]
999541021913	Int/Topo IB signature motif; other site
999541021914	MarR family; Region: MarR_2; cl17246
999541021915	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541021916	H-NS histone family; Region: Histone_HNS; pfam00816
999541021917	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541021918	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021919	Transposase; Region: HTH_Tnp_1; pfam01527
999541021920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541021921	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541021922	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541021923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541021924	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541021925	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541021926	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541021927	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541021928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541021929	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541021930	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
999541021931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541021932	putative substrate translocation pore; other site
999541021933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541021934	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
999541021935	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
999541021936	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
999541021937	Transposase domain (DUF772); Region: DUF772; pfam05598
999541021938	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
999541021939	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
999541021940	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
999541021941	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
999541021942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
999541021943	ATP binding site [chemical binding]; other site
999541021944	Mg2+ binding site [ion binding]; other site
999541021945	G-X-G motif; other site
999541021946	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
999541021947	active site 2 [active]
999541021948	active site 1 [active]
999541021949	Response regulator receiver domain; Region: Response_reg; pfam00072
999541021950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
999541021951	active site
999541021952	phosphorylation site [posttranslational modification]
999541021953	intermolecular recognition site; other site
999541021954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541021955	Transposase; Region: HTH_Tnp_1; pfam01527
999541021956	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541021957	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541021958	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541021959	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541021960	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541021961	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541021962	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
999541021963	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
999541021964	CoenzymeA binding site [chemical binding]; other site
999541021965	subunit interaction site [polypeptide binding]; other site
999541021966	PHB binding site; other site
999541021967	acyl-CoA synthetase; Validated; Region: PRK05850
999541021968	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541021969	acyl-activating enzyme (AAE) consensus motif; other site
999541021970	active site
999541021971	Amidohydrolase; Region: Amidohydro_2; pfam04909
999541021972	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021973	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541021974	Di-iron ligands [ion binding]; other site
999541021975	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021976	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
999541021977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541021978	S-adenosylmethionine binding site [chemical binding]; other site
999541021979	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541021980	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021981	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541021982	Di-iron ligands [ion binding]; other site
999541021983	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
999541021984	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
999541021985	Integrase core domain; Region: rve; pfam00665
999541021986	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
999541021987	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
999541021988	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
999541021989	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
999541021990	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
999541021991	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
999541021992	SLBB domain; Region: SLBB; pfam10531
999541021993	Chain length determinant protein; Region: Wzz; pfam02706
999541021994	tyrosine kinase; Provisional; Region: PRK11519
999541021995	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
999541021996	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
999541021997	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
999541021998	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
999541021999	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
999541022000	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541022001	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
999541022002	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
999541022003	putative ADP-binding pocket [chemical binding]; other site
999541022004	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
999541022005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
999541022006	active site
999541022007	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
999541022008	Right handed beta helix region; Region: Beta_helix; pfam13229
999541022009	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
999541022010	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
999541022011	Substrate binding site; other site
999541022012	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
999541022013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
999541022014	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
999541022015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541022016	Walker A motif; other site
999541022017	ATP binding site [chemical binding]; other site
999541022018	Walker B motif; other site
999541022019	arginine finger; other site
999541022020	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
999541022021	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
999541022022	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
999541022023	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
999541022024	dimer interface [polypeptide binding]; other site
999541022025	motif 1; other site
999541022026	active site
999541022027	motif 2; other site
999541022028	motif 3; other site
999541022029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541022030	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
999541022031	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
999541022032	active site
999541022033	acyl carrier protein; Provisional; Region: PRK07081
999541022034	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541022035	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
999541022036	ligand binding site [chemical binding]; other site
999541022037	flexible hinge region; other site
999541022038	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
999541022039	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
999541022040	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
999541022041	non-specific DNA interactions [nucleotide binding]; other site
999541022042	DNA binding site [nucleotide binding]
999541022043	sequence specific DNA binding site [nucleotide binding]; other site
999541022044	putative cAMP binding site [chemical binding]; other site
999541022045	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
999541022046	Bacterial sugar transferase; Region: Bac_transf; pfam02397
999541022047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022048	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541022049	Transposase; Region: HTH_Tnp_1; pfam01527
999541022050	DDE domain; Region: DDE_Tnp_IS240; pfam13610
999541022051	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
999541022052	dimer interface [polypeptide binding]; other site
999541022053	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
999541022054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
999541022055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
999541022056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541022057	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541022058	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541022059	MarR family; Region: MarR_2; cl17246
999541022060	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
999541022061	H-NS histone family; Region: Histone_HNS; pfam00816
999541022062	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541022063	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
999541022064	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
999541022065	Walker A/P-loop; other site
999541022066	ATP binding site [chemical binding]; other site
999541022067	Q-loop/lid; other site
999541022068	ABC transporter signature motif; other site
999541022069	Walker B; other site
999541022070	D-loop; other site
999541022071	H-loop/switch region; other site
999541022072	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
999541022073	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
999541022074	Walker A/P-loop; other site
999541022075	ATP binding site [chemical binding]; other site
999541022076	Q-loop/lid; other site
999541022077	ABC transporter signature motif; other site
999541022078	Walker B; other site
999541022079	D-loop; other site
999541022080	H-loop/switch region; other site
999541022081	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
999541022082	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
999541022083	dimer interface [polypeptide binding]; other site
999541022084	ssDNA binding site [nucleotide binding]; other site
999541022085	tetramer (dimer of dimers) interface [polypeptide binding]; other site
999541022086	AAA domain; Region: AAA_14; pfam13173
999541022087	DDE superfamily endonuclease; Region: DDE_5; pfam13546
999541022088	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
999541022089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
999541022090	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541022091	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541022092	N-terminal plug; other site
999541022093	ligand-binding site [chemical binding]; other site
999541022094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541022095	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
999541022096	Walker A/P-loop; other site
999541022097	ATP binding site [chemical binding]; other site
999541022098	Q-loop/lid; other site
999541022099	ABC transporter signature motif; other site
999541022100	Walker B; other site
999541022101	D-loop; other site
999541022102	H-loop/switch region; other site
999541022103	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
999541022104	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
999541022105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
999541022106	Walker A/P-loop; other site
999541022107	ATP binding site [chemical binding]; other site
999541022108	Q-loop/lid; other site
999541022109	ABC transporter signature motif; other site
999541022110	Walker B; other site
999541022111	D-loop; other site
999541022112	H-loop/switch region; other site
999541022113	Methyltransferase domain; Region: Methyltransf_31; pfam13847
999541022114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
999541022115	S-adenosylmethionine binding site [chemical binding]; other site
999541022116	Thioesterase domain; Region: Thioesterase; pfam00975
999541022117	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
999541022118	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
999541022119	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541022120	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
999541022121	active site
999541022122	Methyltransferase domain; Region: Methyltransf_12; pfam08242
999541022123	Methyltransferase domain; Region: Methyltransf_23; pfam13489
999541022124	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
999541022125	NADP binding site [chemical binding]; other site
999541022126	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
999541022127	active site
999541022128	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541022129	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
999541022130	acyl-CoA synthetase; Validated; Region: PRK05850
999541022131	acyl-activating enzyme (AAE) consensus motif; other site
999541022132	active site
999541022133	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541022134	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
999541022135	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
999541022136	active site
999541022137	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
999541022138	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
999541022139	KR domain; Region: KR; pfam08659
999541022140	NADP binding site [chemical binding]; other site
999541022141	active site
999541022142	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
999541022143	Condensation domain; Region: Condensation; pfam00668
999541022144	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541022145	Nonribosomal peptide synthase; Region: NRPS; pfam08415
999541022146	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
999541022147	acyl-activating enzyme (AAE) consensus motif; other site
999541022148	AMP binding site [chemical binding]; other site
999541022149	Methyltransferase domain; Region: Methyltransf_12; pfam08242
999541022150	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541022151	Condensation domain; Region: Condensation; pfam00668
999541022152	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541022153	Nonribosomal peptide synthase; Region: NRPS; pfam08415
999541022154	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541022155	Condensation domain; Region: Condensation; pfam00668
999541022156	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
999541022157	Nonribosomal peptide synthase; Region: NRPS; pfam08415
999541022158	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
999541022159	acyl-activating enzyme (AAE) consensus motif; other site
999541022160	AMP binding site [chemical binding]; other site
999541022161	Methyltransferase domain; Region: Methyltransf_12; pfam08242
999541022162	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541022163	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
999541022164	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
999541022165	H-NS histone family; Region: Histone_HNS; pfam00816
999541022166	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541022167	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
999541022168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541022169	Walker A motif; other site
999541022170	ATP binding site [chemical binding]; other site
999541022171	Walker B motif; other site
999541022172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541022173	Transposase; Region: HTH_Tnp_1; pfam01527
999541022174	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541022175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022176	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541022177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022178	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541022179	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541022180	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541022181	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541022182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541022183	Coenzyme A binding pocket [chemical binding]; other site
999541022184	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541022185	Patatin-like phospholipase; Region: Patatin; pfam01734
999541022186	active site
999541022187	nucleophile elbow; other site
999541022188	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
999541022189	putative transposase OrfB; Reviewed; Region: PHA02517
999541022190	HTH-like domain; Region: HTH_21; pfam13276
999541022191	Integrase core domain; Region: rve; pfam00665
999541022192	Integrase core domain; Region: rve_2; pfam13333
999541022193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541022194	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541022195	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541022196	RHS Repeat; Region: RHS_repeat; pfam05593
999541022197	RHS Repeat; Region: RHS_repeat; pfam05593
999541022198	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541022199	RHS Repeat; Region: RHS_repeat; pfam05593
999541022200	RHS Repeat; Region: RHS_repeat; cl11982
999541022201	RHS protein; Region: RHS; pfam03527
999541022202	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541022203	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
999541022204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
999541022205	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541022206	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541022207	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
999541022208	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
999541022209	PAAR motif; Region: PAAR_motif; pfam05488
999541022210	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
999541022211	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541022212	ligand binding site [chemical binding]; other site
999541022213	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
999541022214	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
999541022215	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
999541022216	hypothetical protein; Provisional; Region: PRK08126
999541022217	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
999541022218	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
999541022219	ligand binding site [chemical binding]; other site
999541022220	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
999541022221	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
999541022222	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
999541022223	Protein of unknown function (DUF796); Region: DUF796; pfam05638
999541022224	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
999541022225	Protein of unknown function (DUF877); Region: DUF877; pfam05943
999541022226	Protein of unknown function (DUF770); Region: DUF770; pfam05591
999541022227	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
999541022228	Clp amino terminal domain; Region: Clp_N; pfam02861
999541022229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541022230	Walker A motif; other site
999541022231	ATP binding site [chemical binding]; other site
999541022232	Walker B motif; other site
999541022233	arginine finger; other site
999541022234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
999541022235	Walker A motif; other site
999541022236	ATP binding site [chemical binding]; other site
999541022237	Walker B motif; other site
999541022238	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
999541022239	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
999541022240	ImpE protein; Region: ImpE; pfam07024
999541022241	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
999541022242	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
999541022243	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
999541022244	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
999541022245	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
999541022246	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
999541022247	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
999541022248	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
999541022249	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
999541022250	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
999541022251	ATP binding site [chemical binding]; other site
999541022252	substrate interface [chemical binding]; other site
999541022253	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
999541022254	active site residue [active]
999541022255	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
999541022256	MPN+ (JAMM) motif; other site
999541022257	Zinc-binding site [ion binding]; other site
999541022258	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
999541022259	MoaE interaction surface [polypeptide binding]; other site
999541022260	MoeB interaction surface [polypeptide binding]; other site
999541022261	thiocarboxylated glycine; other site
999541022262	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
999541022263	CoA-transferase family III; Region: CoA_transf_3; pfam02515
999541022264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
999541022265	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
999541022266	acyl-activating enzyme (AAE) consensus motif; other site
999541022267	AMP binding site [chemical binding]; other site
999541022268	active site
999541022269	CoA binding site [chemical binding]; other site
999541022270	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
999541022271	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
999541022272	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
999541022273	active site
999541022274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541022275	putative substrate translocation pore; other site
999541022276	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541022277	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
999541022278	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
999541022279	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
999541022280	N-terminal plug; other site
999541022281	ligand-binding site [chemical binding]; other site
999541022282	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
999541022283	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
999541022284	conserved cys residue [active]
999541022285	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
999541022286	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541022287	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
999541022288	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
999541022289	FMN binding site [chemical binding]; other site
999541022290	substrate binding site [chemical binding]; other site
999541022291	putative catalytic residue [active]
999541022292	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
999541022293	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
999541022294	Fatty acid desaturase; Region: FA_desaturase; pfam00487
999541022295	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
999541022296	Major Facilitator Superfamily; Region: MFS_1; pfam07690
999541022297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
999541022298	putative substrate translocation pore; other site
999541022299	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
999541022300	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
999541022301	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
999541022302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
999541022303	Integrase core domain; Region: rve; pfam00665
999541022304	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
999541022305	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541022306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541022307	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541022308	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
999541022309	H-NS histone family; Region: Histone_HNS; pfam00816
999541022310	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
999541022311	aspartate carbamoyltransferase; Provisional; Region: PRK11891
999541022312	Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282
999541022313	PAAR motif; Region: PAAR_motif; pfam05488
999541022314	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541022315	RHS Repeat; Region: RHS_repeat; pfam05593
999541022316	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
999541022317	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541022318	RHS Repeat; Region: RHS_repeat; pfam05593
999541022319	RHS Repeat; Region: RHS_repeat; cl11982
999541022320	RHS protein; Region: RHS; pfam03527
999541022321	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541022322	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
999541022323	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
999541022324	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
999541022325	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
999541022326	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
999541022327	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
999541022328	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
999541022329	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
999541022330	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
999541022331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
999541022332	non-specific DNA binding site [nucleotide binding]; other site
999541022333	salt bridge; other site
999541022334	sequence-specific DNA binding site [nucleotide binding]; other site
999541022335	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
999541022336	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
999541022337	substrate binding pocket [chemical binding]; other site
999541022338	membrane-bound complex binding site; other site
999541022339	hinge residues; other site
999541022340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
999541022341	dimer interface [polypeptide binding]; other site
999541022342	conserved gate region; other site
999541022343	putative PBP binding loops; other site
999541022344	ABC-ATPase subunit interface; other site
999541022345	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
999541022346	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
999541022347	Walker A/P-loop; other site
999541022348	ATP binding site [chemical binding]; other site
999541022349	Q-loop/lid; other site
999541022350	ABC transporter signature motif; other site
999541022351	Walker B; other site
999541022352	D-loop; other site
999541022353	H-loop/switch region; other site
999541022354	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
999541022355	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
999541022356	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
999541022357	metal binding site [ion binding]; metal-binding site
999541022358	dimer interface [polypeptide binding]; other site
999541022359	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
999541022360	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
999541022361	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
999541022362	dimerization interface [polypeptide binding]; other site
999541022363	hypothetical protein; Provisional; Region: PRK10396
999541022364	yecA family protein; Region: ygfB_yecA; TIGR02292
999541022365	SEC-C motif; Region: SEC-C; pfam02810
999541022366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
999541022367	Integrase core domain; Region: rve; pfam00665
999541022368	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
999541022369	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
999541022370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
999541022371	Integrase core domain; Region: rve; pfam00665
999541022372	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
999541022373	Patatin-like phospholipase; Region: Patatin; pfam01734
999541022374	active site
999541022375	nucleophile elbow; other site
999541022376	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541022377	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022378	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541022379	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541022380	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541022381	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541022382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541022384	Transposase; Region: HTH_Tnp_1; pfam01527
999541022385	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
999541022386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
999541022387	Coenzyme A binding pocket [chemical binding]; other site
999541022388	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
999541022389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022390	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
999541022391	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
999541022392	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
999541022393	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
999541022394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
999541022395	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541022396	Transposase; Region: HTH_Tnp_1; pfam01527
999541022397	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
999541022398	putative transposase OrfB; Reviewed; Region: PHA02517
999541022399	Integrase core domain; Region: rve; pfam00665
999541022400	Integrase core domain; Region: rve_3; pfam13683
999541022401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
999541022402	Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461
999541022403	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
999541022404	ATP binding site [chemical binding]; other site
999541022405	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
999541022406	active site
999541022407	nucleophile elbow; other site
999541022408	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
999541022409	DNA-binding interface [nucleotide binding]; DNA binding site
999541022410	HsdM N-terminal domain; Region: HsdM_N; pfam12161
999541022411	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
999541022412	Methyltransferase domain; Region: Methyltransf_26; pfam13659
999541022413	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
999541022414	H-NS histone family; Region: Histone_HNS; pfam00816
999541022415	Helix-turn-helix domain; Region: HTH_36; pfam13730
999541022416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
999541022417	Transposase; Region: DEDD_Tnp_IS110; pfam01548
999541022418	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
999541022419	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
999541022420	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
999541022421	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
999541022422	IHF - DNA interface [nucleotide binding]; other site
999541022423	IHF dimer interface [polypeptide binding]; other site
999541022424	Methyltransferase domain; Region: Methyltransf_26; pfam13659
999541022425	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
999541022426	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
999541022427	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
999541022428	Int/Topo IB signature motif; other site
999541022429	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
999541022430	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
999541022431	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541022432	RHS Repeat; Region: RHS_repeat; pfam05593
999541022433	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
999541022434	RHS Repeat; Region: RHS_repeat; cl11982
999541022435	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
999541022436	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
999541022437	AAA domain; Region: AAA_22; pfam13401
999541022438	Phage integrase protein; Region: DUF3701; pfam12482
999541022439	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
999541022440	active site
999541022441	DNA binding site [nucleotide binding]
999541022442	Int/Topo IB signature motif; other site