-- dump date 20140619_013643 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243160000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 243160000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 243160000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160000004 Walker A motif; other site 243160000005 ATP binding site [chemical binding]; other site 243160000006 Walker B motif; other site 243160000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 243160000008 arginine finger; other site 243160000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243160000010 DnaA box-binding interface [nucleotide binding]; other site 243160000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 243160000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243160000013 putative DNA binding surface [nucleotide binding]; other site 243160000014 dimer interface [polypeptide binding]; other site 243160000015 beta-clamp/clamp loader binding surface; other site 243160000016 beta-clamp/translesion DNA polymerase binding surface; other site 243160000017 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 243160000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160000019 ATP binding site [chemical binding]; other site 243160000020 Mg2+ binding site [ion binding]; other site 243160000021 G-X-G motif; other site 243160000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243160000023 anchoring element; other site 243160000024 dimer interface [polypeptide binding]; other site 243160000025 ATP binding site [chemical binding]; other site 243160000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243160000027 active site 243160000028 putative metal-binding site [ion binding]; other site 243160000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243160000030 Transposase; Region: HTH_Tnp_1; pfam01527 243160000031 HTH-like domain; Region: HTH_21; pfam13276 243160000032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000033 Integrase core domain; Region: rve; pfam00665 243160000034 Integrase core domain; Region: rve_3; pfam13683 243160000035 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243160000036 Family description; Region: VCBS; pfam13517 243160000037 Family description; Region: VCBS; pfam13517 243160000038 Family description; Region: VCBS; pfam13517 243160000039 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 243160000040 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 243160000041 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243160000042 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 243160000043 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243160000044 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243160000045 phosphopeptide binding site; other site 243160000046 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 243160000047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243160000048 substrate binding site [chemical binding]; other site 243160000049 activation loop (A-loop); other site 243160000050 cyclase homology domain; Region: CHD; cd07302 243160000051 dimer interface [polypeptide binding]; other site 243160000052 nucleotidyl binding site; other site 243160000053 metal binding site [ion binding]; metal-binding site 243160000054 AAA ATPase domain; Region: AAA_16; pfam13191 243160000055 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 243160000056 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 243160000057 YcaO-like family; Region: YcaO; pfam02624 243160000058 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 243160000059 aldolase II superfamily protein; Provisional; Region: PRK07044 243160000060 intersubunit interface [polypeptide binding]; other site 243160000061 active site 243160000062 Zn2+ binding site [ion binding]; other site 243160000063 PAS domain; Region: PAS; smart00091 243160000064 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160000065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160000066 metal binding site [ion binding]; metal-binding site 243160000067 active site 243160000068 I-site; other site 243160000069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160000070 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243160000071 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243160000072 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160000073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160000074 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243160000075 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243160000076 Substrate binding site; other site 243160000077 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243160000078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160000079 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160000080 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 243160000081 putative ADP-binding pocket [chemical binding]; other site 243160000082 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 243160000083 active site 243160000084 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160000085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160000086 Walker A motif; other site 243160000087 ATP binding site [chemical binding]; other site 243160000088 Walker B motif; other site 243160000089 arginine finger; other site 243160000090 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 243160000091 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 243160000092 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 243160000093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160000094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160000095 active site 243160000096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160000097 active site 243160000098 acyl carrier protein; Provisional; Region: PRK07081 243160000099 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243160000100 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160000101 ligand binding site [chemical binding]; other site 243160000102 flexible hinge region; other site 243160000103 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 243160000104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243160000105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 243160000106 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243160000107 non-specific DNA interactions [nucleotide binding]; other site 243160000108 DNA binding site [nucleotide binding] 243160000109 sequence specific DNA binding site [nucleotide binding]; other site 243160000110 putative cAMP binding site [chemical binding]; other site 243160000111 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 243160000112 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243160000113 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243160000114 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 243160000115 SLBB domain; Region: SLBB; pfam10531 243160000116 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243160000117 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 243160000118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160000119 Transposase domain (DUF772); Region: DUF772; pfam05598 243160000120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160000121 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160000122 lipoyl synthase; Provisional; Region: PRK05481 243160000123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160000124 FeS/SAM binding site; other site 243160000125 lipoate-protein ligase B; Provisional; Region: PRK14343 243160000126 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160000127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000128 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 243160000129 dimerization interface [polypeptide binding]; other site 243160000130 substrate binding pocket [chemical binding]; other site 243160000131 hypothetical protein; Provisional; Region: PRK02047 243160000132 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 243160000133 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243160000134 homodimer interface [polypeptide binding]; other site 243160000135 substrate-cofactor binding pocket; other site 243160000136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160000137 catalytic residue [active] 243160000138 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 243160000139 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243160000140 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 243160000141 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 243160000142 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243160000143 dimer interface [polypeptide binding]; other site 243160000144 [2Fe-2S] cluster binding site [ion binding]; other site 243160000145 Protein of unknown function (DUF330); Region: DUF330; pfam03886 243160000146 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243160000147 mce related protein; Region: MCE; pfam02470 243160000148 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243160000149 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243160000150 Walker A/P-loop; other site 243160000151 ATP binding site [chemical binding]; other site 243160000152 Q-loop/lid; other site 243160000153 ABC transporter signature motif; other site 243160000154 Walker B; other site 243160000155 D-loop; other site 243160000156 H-loop/switch region; other site 243160000157 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243160000158 Permease; Region: Permease; pfam02405 243160000159 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 243160000160 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 243160000161 active site 243160000162 metal binding site [ion binding]; metal-binding site 243160000163 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 243160000164 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243160000165 Sel1-like repeats; Region: SEL1; smart00671 243160000166 Sel1-like repeats; Region: SEL1; smart00671 243160000167 biotin--protein ligase; Provisional; Region: PRK06955 243160000168 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 243160000169 pantothenate kinase; Reviewed; Region: PRK13328 243160000170 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 243160000171 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 243160000172 active site 243160000173 HIGH motif; other site 243160000174 nucleotide binding site [chemical binding]; other site 243160000175 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243160000176 dinuclear metal binding motif [ion binding]; other site 243160000177 enoyl-CoA hydratase; Provisional; Region: PRK07657 243160000178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160000179 substrate binding site [chemical binding]; other site 243160000180 oxyanion hole (OAH) forming residues; other site 243160000181 trimer interface [polypeptide binding]; other site 243160000182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 243160000183 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243160000184 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243160000185 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160000186 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160000187 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160000188 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 243160000189 Transposase domain (DUF772); Region: DUF772; pfam05598 243160000190 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160000191 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160000192 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 243160000193 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 243160000194 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 243160000195 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243160000196 active site 243160000197 HIGH motif; other site 243160000198 KMSK motif region; other site 243160000199 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243160000200 tRNA binding surface [nucleotide binding]; other site 243160000201 anticodon binding site; other site 243160000202 Sporulation related domain; Region: SPOR; pfam05036 243160000203 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 243160000204 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 243160000205 catalytic residues [active] 243160000206 hinge region; other site 243160000207 alpha helical domain; other site 243160000208 short chain dehydrogenase; Provisional; Region: PRK07024 243160000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160000210 NAD(P) binding site [chemical binding]; other site 243160000211 active site 243160000212 short chain dehydrogenase; Validated; Region: PRK08264 243160000213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160000214 NAD(P) binding site [chemical binding]; other site 243160000215 active site 243160000216 MarR family; Region: MarR_2; cl17246 243160000217 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243160000218 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243160000219 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 243160000220 peptide binding site [polypeptide binding]; other site 243160000221 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243160000222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160000223 Walker A/P-loop; other site 243160000224 ATP binding site [chemical binding]; other site 243160000225 Q-loop/lid; other site 243160000226 ABC transporter signature motif; other site 243160000227 Walker B; other site 243160000228 D-loop; other site 243160000229 H-loop/switch region; other site 243160000230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160000231 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243160000232 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 243160000233 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 243160000234 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 243160000235 active site clefts [active] 243160000236 zinc binding site [ion binding]; other site 243160000237 dimer interface [polypeptide binding]; other site 243160000238 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 243160000239 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160000240 dimer interface [polypeptide binding]; other site 243160000241 active site 243160000242 short chain dehydrogenase; Provisional; Region: PRK06953 243160000243 NAD(P) binding site [chemical binding]; other site 243160000244 active site 243160000245 hypothetical protein; Provisional; Region: PRK01842 243160000246 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 243160000247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160000248 inhibitor-cofactor binding pocket; inhibition site 243160000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160000250 catalytic residue [active] 243160000251 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 243160000252 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243160000253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160000254 catalytic residue [active] 243160000255 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243160000256 AAA domain; Region: AAA_26; pfam13500 243160000257 biotin synthase; Region: bioB; TIGR00433 243160000258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160000259 FeS/SAM binding site; other site 243160000260 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 243160000261 CutC family; Region: CutC; cl01218 243160000262 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 243160000263 Alkaline phosphatase homologues; Region: alkPPc; smart00098 243160000264 active site 243160000265 dimer interface [polypeptide binding]; other site 243160000266 HTH-like domain; Region: HTH_21; pfam13276 243160000267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000268 Integrase core domain; Region: rve; pfam00665 243160000269 Integrase core domain; Region: rve_3; pfam13683 243160000270 Transposase; Region: HTH_Tnp_1; pfam01527 243160000271 YaeQ protein; Region: YaeQ; pfam07152 243160000272 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 243160000273 dimer interface [polypeptide binding]; other site 243160000274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160000275 metal binding site [ion binding]; metal-binding site 243160000276 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 243160000277 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 243160000278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160000279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160000280 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 243160000281 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243160000282 DNA binding site [nucleotide binding] 243160000283 active site 243160000284 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 243160000285 AlkA N-terminal domain; Region: AlkA_N; pfam06029 243160000286 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243160000287 minor groove reading motif; other site 243160000288 helix-hairpin-helix signature motif; other site 243160000289 substrate binding pocket [chemical binding]; other site 243160000290 active site 243160000291 glutamate--cysteine ligase; Provisional; Region: PRK02107 243160000292 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 243160000293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160000294 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243160000295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160000296 DNA binding residues [nucleotide binding] 243160000297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160000298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000299 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160000300 putative effector binding pocket; other site 243160000301 dimerization interface [polypeptide binding]; other site 243160000302 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 243160000303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243160000304 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 243160000305 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243160000306 active site 243160000307 metal binding site [ion binding]; metal-binding site 243160000308 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 243160000309 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 243160000310 putative active site; other site 243160000311 catalytic triad [active] 243160000312 putative dimer interface [polypeptide binding]; other site 243160000313 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 243160000314 portal vertex protein; Provisional; Region: Q; PHA02536 243160000315 Phage portal protein; Region: Phage_portal; pfam04860 243160000316 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 243160000317 HTH-like domain; Region: HTH_21; pfam13276 243160000318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000319 Integrase core domain; Region: rve; pfam00665 243160000320 Integrase core domain; Region: rve_3; pfam13683 243160000321 Transposase; Region: HTH_Tnp_1; pfam01527 243160000322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160000323 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160000324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160000325 CoenzymeA binding site [chemical binding]; other site 243160000326 subunit interaction site [polypeptide binding]; other site 243160000327 PHB binding site; other site 243160000328 Patatin-like phospholipase; Region: Patatin; pfam01734 243160000329 active site 243160000330 nucleophile elbow; other site 243160000331 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 243160000332 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 243160000333 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 243160000334 dimerization interface [polypeptide binding]; other site 243160000335 NAD binding site [chemical binding]; other site 243160000336 ligand binding site [chemical binding]; other site 243160000337 catalytic site [active] 243160000338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160000339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000340 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160000341 putative effector binding pocket; other site 243160000342 dimerization interface [polypeptide binding]; other site 243160000343 DNA topoisomerase III; Validated; Region: PRK08173 243160000344 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 243160000345 active site 243160000346 putative interdomain interaction site [polypeptide binding]; other site 243160000347 putative metal-binding site [ion binding]; other site 243160000348 putative nucleotide binding site [chemical binding]; other site 243160000349 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243160000350 domain I; other site 243160000351 DNA binding groove [nucleotide binding] 243160000352 phosphate binding site [ion binding]; other site 243160000353 domain II; other site 243160000354 domain III; other site 243160000355 nucleotide binding site [chemical binding]; other site 243160000356 catalytic site [active] 243160000357 domain IV; other site 243160000358 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 243160000359 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 243160000360 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243160000361 catalytic residues [active] 243160000362 DNA protecting protein DprA; Region: dprA; TIGR00732 243160000363 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 243160000364 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243160000365 active site 243160000366 catalytic residues [active] 243160000367 metal binding site [ion binding]; metal-binding site 243160000368 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243160000369 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243160000370 putative active site [active] 243160000371 substrate binding site [chemical binding]; other site 243160000372 putative cosubstrate binding site; other site 243160000373 catalytic site [active] 243160000374 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243160000375 substrate binding site [chemical binding]; other site 243160000376 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160000377 M48 family peptidase; Provisional; Region: PRK03001 243160000378 16S rRNA methyltransferase B; Provisional; Region: PRK10901 243160000379 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 243160000380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160000381 S-adenosylmethionine binding site [chemical binding]; other site 243160000382 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 243160000383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160000384 dimerization interface [polypeptide binding]; other site 243160000385 PAS domain; Region: PAS; smart00091 243160000386 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243160000387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160000388 dimer interface [polypeptide binding]; other site 243160000389 phosphorylation site [posttranslational modification] 243160000390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160000391 ATP binding site [chemical binding]; other site 243160000392 Mg2+ binding site [ion binding]; other site 243160000393 G-X-G motif; other site 243160000394 Response regulator receiver domain; Region: Response_reg; pfam00072 243160000395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160000396 active site 243160000397 phosphorylation site [posttranslational modification] 243160000398 intermolecular recognition site; other site 243160000399 dimerization interface [polypeptide binding]; other site 243160000400 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243160000401 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 243160000402 Ligand Binding Site [chemical binding]; other site 243160000403 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 243160000404 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 243160000405 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 243160000406 active site 243160000407 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243160000408 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243160000409 Sel1 repeat; Region: Sel1; cl02723 243160000410 Sel1-like repeats; Region: SEL1; smart00671 243160000411 Sel1-like repeats; Region: SEL1; smart00671 243160000412 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 243160000413 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 243160000414 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243160000415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243160000416 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 243160000417 rod shape-determining protein MreC; Provisional; Region: PRK13922 243160000418 rod shape-determining protein MreC; Region: MreC; pfam04085 243160000419 rod shape-determining protein MreB; Provisional; Region: PRK13927 243160000420 MreB and similar proteins; Region: MreB_like; cd10225 243160000421 nucleotide binding site [chemical binding]; other site 243160000422 Mg binding site [ion binding]; other site 243160000423 putative protofilament interaction site [polypeptide binding]; other site 243160000424 RodZ interaction site [polypeptide binding]; other site 243160000425 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243160000426 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243160000427 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243160000428 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243160000429 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243160000430 GatB domain; Region: GatB_Yqey; smart00845 243160000431 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 243160000432 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 243160000433 putative active site [active] 243160000434 putative catalytic site [active] 243160000435 putative DNA binding site [nucleotide binding]; other site 243160000436 putative phosphate binding site [ion binding]; other site 243160000437 metal binding site A [ion binding]; metal-binding site 243160000438 putative AP binding site [nucleotide binding]; other site 243160000439 putative metal binding site B [ion binding]; other site 243160000440 Transposase domain (DUF772); Region: DUF772; pfam05598 243160000441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160000442 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160000443 CHRD domain; Region: CHRD; pfam07452 243160000444 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243160000445 EcsC protein family; Region: EcsC; pfam12787 243160000446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160000448 putative substrate translocation pore; other site 243160000449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000450 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243160000451 MarR family; Region: MarR; pfam01047 243160000452 MarR family; Region: MarR_2; cl17246 243160000453 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243160000454 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 243160000455 conserved cys residue [active] 243160000456 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 243160000457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 243160000458 dimer interface [polypeptide binding]; other site 243160000459 active site 243160000460 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160000461 substrate binding site [chemical binding]; other site 243160000462 catalytic residue [active] 243160000463 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160000464 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160000465 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160000466 putative active site [active] 243160000467 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243160000468 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 243160000469 active site 243160000470 putative substrate binding pocket [chemical binding]; other site 243160000471 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 243160000472 homotrimer interaction site [polypeptide binding]; other site 243160000473 putative active site [active] 243160000474 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 243160000475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 243160000476 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 243160000477 threonine dehydratase; Reviewed; Region: PRK09224 243160000478 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243160000479 tetramer interface [polypeptide binding]; other site 243160000480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160000481 catalytic residue [active] 243160000482 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 243160000483 putative Ile/Val binding site [chemical binding]; other site 243160000484 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243160000485 putative Ile/Val binding site [chemical binding]; other site 243160000486 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 243160000487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160000488 FAD binding domain; Region: FAD_binding_4; pfam01565 243160000489 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160000490 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243160000491 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243160000492 Cysteine-rich domain; Region: CCG; pfam02754 243160000493 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 243160000494 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 243160000495 nucleotide binding site/active site [active] 243160000496 HIT family signature motif; other site 243160000497 catalytic residue [active] 243160000498 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243160000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160000500 S-adenosylmethionine binding site [chemical binding]; other site 243160000501 Tim44-like domain; Region: Tim44; pfam04280 243160000502 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 243160000503 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243160000504 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 243160000505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160000506 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243160000507 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243160000508 dimer interface [polypeptide binding]; other site 243160000509 anticodon binding site; other site 243160000510 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243160000511 homodimer interface [polypeptide binding]; other site 243160000512 motif 1; other site 243160000513 active site 243160000514 motif 2; other site 243160000515 GAD domain; Region: GAD; pfam02938 243160000516 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243160000517 motif 3; other site 243160000518 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 243160000519 nudix motif; other site 243160000520 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 243160000521 PLD-like domain; Region: PLDc_2; pfam13091 243160000522 putative active site [active] 243160000523 catalytic site [active] 243160000524 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243160000525 PLD-like domain; Region: PLDc_2; pfam13091 243160000526 putative active site [active] 243160000527 catalytic site [active] 243160000528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160000529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160000530 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 243160000531 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 243160000532 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 243160000533 FAD binding site [chemical binding]; other site 243160000534 substrate binding site [chemical binding]; other site 243160000535 catalytic residues [active] 243160000536 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 243160000537 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 243160000538 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243160000539 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160000540 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243160000541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160000542 substrate binding site [chemical binding]; other site 243160000543 oxyanion hole (OAH) forming residues; other site 243160000544 trimer interface [polypeptide binding]; other site 243160000545 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 243160000546 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160000547 dimer interface [polypeptide binding]; other site 243160000548 active site 243160000549 enoyl-CoA hydratase; Provisional; Region: PRK06688 243160000550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160000551 substrate binding site [chemical binding]; other site 243160000552 oxyanion hole (OAH) forming residues; other site 243160000553 trimer interface [polypeptide binding]; other site 243160000554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 243160000555 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 243160000556 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 243160000557 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 243160000558 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 243160000559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160000561 Walker A/P-loop; other site 243160000562 ATP binding site [chemical binding]; other site 243160000563 Q-loop/lid; other site 243160000564 ABC transporter signature motif; other site 243160000565 Walker B; other site 243160000566 D-loop; other site 243160000567 H-loop/switch region; other site 243160000568 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243160000569 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 243160000570 Substrate binding site; other site 243160000571 metal-binding site 243160000572 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 243160000573 Phosphotransferase enzyme family; Region: APH; pfam01636 243160000574 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 243160000575 Organic solvent tolerance protein; Region: OstA_C; pfam04453 243160000576 SurA N-terminal domain; Region: SurA_N; pfam09312 243160000577 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 243160000578 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243160000579 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243160000580 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 243160000581 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 243160000582 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243160000583 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 243160000584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160000585 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 243160000586 dimer interface [polypeptide binding]; other site 243160000587 active site 243160000588 metal binding site [ion binding]; metal-binding site 243160000589 glutathione binding site [chemical binding]; other site 243160000590 Protein of unknown function DUF45; Region: DUF45; pfam01863 243160000591 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243160000592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243160000593 putative acyl-acceptor binding pocket; other site 243160000594 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 243160000595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160000596 active site 243160000597 motif I; other site 243160000598 motif II; other site 243160000599 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 243160000600 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 243160000601 dimer interface [polypeptide binding]; other site 243160000602 motif 1; other site 243160000603 active site 243160000604 motif 2; other site 243160000605 motif 3; other site 243160000606 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 243160000607 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 243160000608 putative active site [active] 243160000609 catalytic triad [active] 243160000610 putative dimer interface [polypeptide binding]; other site 243160000611 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 243160000612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243160000613 Transporter associated domain; Region: CorC_HlyC; smart01091 243160000614 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243160000615 putative active site pocket [active] 243160000616 dimerization interface [polypeptide binding]; other site 243160000617 putative catalytic residue [active] 243160000618 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 243160000619 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 243160000620 PhoH-like protein; Region: PhoH; pfam02562 243160000621 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 243160000622 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243160000623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160000624 FeS/SAM binding site; other site 243160000625 TRAM domain; Region: TRAM; pfam01938 243160000626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160000627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160000629 putative effector binding pocket; other site 243160000630 dimerization interface [polypeptide binding]; other site 243160000631 MFS transport protein AraJ; Provisional; Region: PRK10091 243160000632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000633 putative substrate translocation pore; other site 243160000634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243160000635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160000636 non-specific DNA binding site [nucleotide binding]; other site 243160000637 salt bridge; other site 243160000638 sequence-specific DNA binding site [nucleotide binding]; other site 243160000639 Cupin domain; Region: Cupin_2; pfam07883 243160000640 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 243160000641 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 243160000642 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243160000643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160000644 motif II; other site 243160000645 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243160000646 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243160000647 active site 243160000648 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 243160000649 dimer interface [polypeptide binding]; other site 243160000650 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243160000651 Ligand Binding Site [chemical binding]; other site 243160000652 Molecular Tunnel; other site 243160000653 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243160000654 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243160000655 hinge; other site 243160000656 active site 243160000657 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 243160000658 homotrimer interaction site [polypeptide binding]; other site 243160000659 putative active site [active] 243160000660 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 243160000661 amphipathic channel; other site 243160000662 Asn-Pro-Ala signature motifs; other site 243160000663 glycerol kinase; Provisional; Region: glpK; PRK00047 243160000664 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 243160000665 N- and C-terminal domain interface [polypeptide binding]; other site 243160000666 active site 243160000667 MgATP binding site [chemical binding]; other site 243160000668 catalytic site [active] 243160000669 metal binding site [ion binding]; metal-binding site 243160000670 glycerol binding site [chemical binding]; other site 243160000671 homotetramer interface [polypeptide binding]; other site 243160000672 homodimer interface [polypeptide binding]; other site 243160000673 FBP binding site [chemical binding]; other site 243160000674 protein IIAGlc interface [polypeptide binding]; other site 243160000675 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 243160000676 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 243160000677 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 243160000678 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 243160000679 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243160000680 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243160000681 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243160000682 dinuclear metal binding motif [ion binding]; other site 243160000683 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243160000684 ATP binding site [chemical binding]; other site 243160000685 Mg++ binding site [ion binding]; other site 243160000686 motif III; other site 243160000687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160000688 nucleotide binding region [chemical binding]; other site 243160000689 ATP-binding site [chemical binding]; other site 243160000690 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160000691 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160000692 Cytochrome c; Region: Cytochrom_C; pfam00034 243160000693 Cytochrome c; Region: Cytochrom_C; cl11414 243160000694 Cytochrome c; Region: Cytochrom_C; cl11414 243160000695 Copper resistance protein D; Region: CopD; pfam05425 243160000696 galactonate dehydratase; Provisional; Region: PRK14017 243160000697 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 243160000698 putative active site pocket [active] 243160000699 putative metal binding site [ion binding]; other site 243160000700 Uncharacterized conserved protein [Function unknown]; Region: COG3791 243160000701 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160000702 active site 243160000703 metal binding site [ion binding]; metal-binding site 243160000704 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 243160000705 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 243160000706 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 243160000707 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 243160000708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160000709 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 243160000710 linker region; other site 243160000711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160000712 ATP binding site [chemical binding]; other site 243160000713 Mg2+ binding site [ion binding]; other site 243160000714 G-X-G motif; other site 243160000715 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243160000716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160000717 active site 243160000718 phosphorylation site [posttranslational modification] 243160000719 intermolecular recognition site; other site 243160000720 dimerization interface [polypeptide binding]; other site 243160000721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243160000722 Zn2+ binding site [ion binding]; other site 243160000723 Mg2+ binding site [ion binding]; other site 243160000724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160000725 PAS domain; Region: PAS_9; pfam13426 243160000726 putative active site [active] 243160000727 heme pocket [chemical binding]; other site 243160000728 HAMP domain; Region: HAMP; pfam00672 243160000729 dimerization interface [polypeptide binding]; other site 243160000730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160000731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160000732 dimer interface [polypeptide binding]; other site 243160000733 putative CheW interface [polypeptide binding]; other site 243160000734 Transposase; Region: HTH_Tnp_1; pfam01527 243160000735 HTH-like domain; Region: HTH_21; pfam13276 243160000736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000737 Integrase core domain; Region: rve; pfam00665 243160000738 Integrase core domain; Region: rve_3; pfam13683 243160000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000740 putative substrate translocation pore; other site 243160000741 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 243160000742 HAMP domain; Region: HAMP; pfam00672 243160000743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160000744 dimer interface [polypeptide binding]; other site 243160000745 phosphorylation site [posttranslational modification] 243160000746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160000747 ATP binding site [chemical binding]; other site 243160000748 Mg2+ binding site [ion binding]; other site 243160000749 G-X-G motif; other site 243160000750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160000751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160000752 active site 243160000753 phosphorylation site [posttranslational modification] 243160000754 intermolecular recognition site; other site 243160000755 dimerization interface [polypeptide binding]; other site 243160000756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160000757 DNA binding site [nucleotide binding] 243160000758 recombinase A; Provisional; Region: recA; PRK09354 243160000759 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243160000760 hexamer interface [polypeptide binding]; other site 243160000761 Walker A motif; other site 243160000762 ATP binding site [chemical binding]; other site 243160000763 Walker B motif; other site 243160000764 recombination regulator RecX; Provisional; Region: recX; PRK14136 243160000765 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 243160000766 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243160000767 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243160000768 CoA-ligase; Region: Ligase_CoA; pfam00549 243160000769 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243160000770 CoA binding domain; Region: CoA_binding; smart00881 243160000771 CoA-ligase; Region: Ligase_CoA; pfam00549 243160000772 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 243160000773 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 243160000774 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243160000775 O-Antigen ligase; Region: Wzy_C; pfam04932 243160000776 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 243160000777 hypothetical protein; Provisional; Region: PRK11667 243160000778 Gram-negative bacterial tonB protein; Region: TonB; cl10048 243160000779 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 243160000780 HTH-like domain; Region: HTH_21; pfam13276 243160000781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000782 Integrase core domain; Region: rve; pfam00665 243160000783 Integrase core domain; Region: rve_3; pfam13683 243160000784 Transposase; Region: HTH_Tnp_1; pfam01527 243160000785 Peptidase family M48; Region: Peptidase_M48; pfam01435 243160000786 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 243160000787 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 243160000788 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 243160000789 SnoaL-like domain; Region: SnoaL_3; pfam13474 243160000790 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160000791 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160000792 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160000793 putative active site [active] 243160000794 Zinc-finger domain; Region: zf-CHCC; cl01821 243160000795 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243160000796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 243160000797 homodimer interface [polypeptide binding]; other site 243160000798 substrate-cofactor binding pocket; other site 243160000799 catalytic residue [active] 243160000800 AzlC protein; Region: AzlC; cl00570 243160000801 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 243160000802 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 243160000803 Phosphoglycerate kinase; Region: PGK; pfam00162 243160000804 substrate binding site [chemical binding]; other site 243160000805 hinge regions; other site 243160000806 ADP binding site [chemical binding]; other site 243160000807 catalytic site [active] 243160000808 pyruvate kinase; Provisional; Region: PRK05826 243160000809 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243160000810 domain interfaces; other site 243160000811 active site 243160000812 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 243160000813 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243160000814 intersubunit interface [polypeptide binding]; other site 243160000815 active site 243160000816 zinc binding site [ion binding]; other site 243160000817 Na+ binding site [ion binding]; other site 243160000818 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 243160000819 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 243160000820 ATP binding site [chemical binding]; other site 243160000821 active site 243160000822 substrate binding site [chemical binding]; other site 243160000823 AIR carboxylase; Region: AIRC; pfam00731 243160000824 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 243160000825 ATP-grasp domain; Region: ATP-grasp; pfam02222 243160000826 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243160000827 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 243160000828 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 243160000829 active site 243160000830 catalytic triad [active] 243160000831 oxyanion hole [active] 243160000832 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 243160000833 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 243160000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160000835 active site 243160000836 phosphorylation site [posttranslational modification] 243160000837 intermolecular recognition site; other site 243160000838 dimerization interface [polypeptide binding]; other site 243160000839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160000840 DNA binding site [nucleotide binding] 243160000841 sensor protein QseC; Provisional; Region: PRK10337 243160000842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160000843 ATP binding site [chemical binding]; other site 243160000844 Mg2+ binding site [ion binding]; other site 243160000845 G-X-G motif; other site 243160000846 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243160000847 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243160000848 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160000849 protein binding site [polypeptide binding]; other site 243160000850 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160000851 protein binding site [polypeptide binding]; other site 243160000852 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243160000853 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 243160000854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160000855 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 243160000856 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 243160000857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160000858 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160000859 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 243160000860 Protein export membrane protein; Region: SecD_SecF; cl14618 243160000861 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243160000862 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 243160000863 HTH-like domain; Region: HTH_21; pfam13276 243160000864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160000865 Integrase core domain; Region: rve; pfam00665 243160000866 Integrase core domain; Region: rve_3; pfam13683 243160000867 Transposase; Region: HTH_Tnp_1; pfam01527 243160000868 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160000869 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 243160000870 conserved cys residue [active] 243160000871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160000872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160000873 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 243160000874 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 243160000875 substrate binding site [chemical binding]; other site 243160000876 catalytic Zn binding site [ion binding]; other site 243160000877 NAD binding site [chemical binding]; other site 243160000878 structural Zn binding site [ion binding]; other site 243160000879 dimer interface [polypeptide binding]; other site 243160000880 S-formylglutathione hydrolase; Region: PLN02442 243160000881 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 243160000882 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 243160000883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 243160000884 dimer interface [polypeptide binding]; other site 243160000885 putative PBP binding regions; other site 243160000886 ABC-ATPase subunit interface; other site 243160000887 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 243160000888 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 243160000889 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 243160000890 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 243160000891 metal binding site [ion binding]; metal-binding site 243160000892 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243160000893 metal binding site 2 [ion binding]; metal-binding site 243160000894 putative DNA binding helix; other site 243160000895 metal binding site 1 [ion binding]; metal-binding site 243160000896 dimer interface [polypeptide binding]; other site 243160000897 structural Zn2+ binding site [ion binding]; other site 243160000898 sorbitol dehydrogenase; Provisional; Region: PRK07067 243160000899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160000900 NAD(P) binding site [chemical binding]; other site 243160000901 active site 243160000902 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160000903 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 243160000904 substrate binding site [chemical binding]; other site 243160000905 ATP binding site [chemical binding]; other site 243160000906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243160000907 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160000908 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 243160000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160000910 dimer interface [polypeptide binding]; other site 243160000911 conserved gate region; other site 243160000912 putative PBP binding loops; other site 243160000913 ABC-ATPase subunit interface; other site 243160000914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160000915 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243160000916 active site 243160000917 motif I; other site 243160000918 motif II; other site 243160000919 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 243160000920 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 243160000921 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 243160000922 Walker A/P-loop; other site 243160000923 ATP binding site [chemical binding]; other site 243160000924 Q-loop/lid; other site 243160000925 ABC transporter signature motif; other site 243160000926 Walker B; other site 243160000927 D-loop; other site 243160000928 H-loop/switch region; other site 243160000929 TOBE domain; Region: TOBE; pfam03459 243160000930 TOBE domain; Region: TOBE_2; pfam08402 243160000931 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 243160000932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160000933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000934 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 243160000935 putative effector binding pocket; other site 243160000936 putative dimerization interface [polypeptide binding]; other site 243160000937 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243160000938 Beta-lactamase; Region: Beta-lactamase; pfam00144 243160000939 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243160000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000941 putative substrate translocation pore; other site 243160000942 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 243160000943 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 243160000944 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 243160000945 N- and C-terminal domain interface [polypeptide binding]; other site 243160000946 D-xylulose kinase; Region: XylB; TIGR01312 243160000947 active site 243160000948 MgATP binding site [chemical binding]; other site 243160000949 catalytic site [active] 243160000950 metal binding site [ion binding]; metal-binding site 243160000951 xylulose binding site [chemical binding]; other site 243160000952 homodimer interface [polypeptide binding]; other site 243160000953 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243160000954 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243160000955 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243160000956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160000957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160000958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160000959 dimerization interface [polypeptide binding]; other site 243160000960 benzoylformate decarboxylase; Reviewed; Region: PRK07092 243160000961 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160000962 PYR/PP interface [polypeptide binding]; other site 243160000963 dimer interface [polypeptide binding]; other site 243160000964 TPP binding site [chemical binding]; other site 243160000965 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160000966 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 243160000967 TPP-binding site [chemical binding]; other site 243160000968 dimer interface [polypeptide binding]; other site 243160000969 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 243160000970 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 243160000971 NAD(P) binding site [chemical binding]; other site 243160000972 catalytic residues [active] 243160000973 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 243160000974 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243160000975 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243160000976 benzoate transport; Region: 2A0115; TIGR00895 243160000977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000978 putative substrate translocation pore; other site 243160000979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160000980 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 243160000981 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 243160000982 kynureninase; Region: kynureninase; TIGR01814 243160000983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160000984 catalytic residue [active] 243160000985 Putative cyclase; Region: Cyclase; cl00814 243160000986 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160000987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160000988 putative DNA binding site [nucleotide binding]; other site 243160000989 putative Zn2+ binding site [ion binding]; other site 243160000990 AsnC family; Region: AsnC_trans_reg; pfam01037 243160000991 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 243160000992 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243160000993 Protein of unknown function DUF72; Region: DUF72; pfam01904 243160000994 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 243160000995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160000996 S-adenosylmethionine binding site [chemical binding]; other site 243160000997 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 243160000998 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243160000999 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 243160001000 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 243160001001 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 243160001002 putative ATP binding site [chemical binding]; other site 243160001003 putative substrate interface [chemical binding]; other site 243160001004 Pirin-related protein [General function prediction only]; Region: COG1741 243160001005 Pirin; Region: Pirin; pfam02678 243160001006 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243160001007 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 243160001008 EamA-like transporter family; Region: EamA; pfam00892 243160001009 AMIN domain; Region: AMIN; pfam11741 243160001010 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243160001011 active site 243160001012 metal binding site [ion binding]; metal-binding site 243160001013 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 243160001014 epoxyqueuosine reductase; Region: TIGR00276 243160001015 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 243160001016 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 243160001017 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243160001018 DNA binding site [nucleotide binding] 243160001019 active site 243160001020 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 243160001021 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 243160001022 active site 243160001023 Int/Topo IB signature motif; other site 243160001024 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243160001025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160001026 acyl-activating enzyme (AAE) consensus motif; other site 243160001027 AMP binding site [chemical binding]; other site 243160001028 active site 243160001029 CoA binding site [chemical binding]; other site 243160001030 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 243160001031 putative deacylase active site [active] 243160001032 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 243160001033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 243160001034 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 243160001035 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 243160001036 FAD binding domain; Region: FAD_binding_4; pfam01565 243160001037 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243160001038 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243160001039 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243160001040 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243160001041 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 243160001042 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243160001043 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 243160001044 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 243160001045 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 243160001046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160001047 NAD(P) binding site [chemical binding]; other site 243160001048 active site 243160001049 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001051 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001052 thymidylate synthase; Provisional; Region: thyA; PRK13821 243160001053 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 243160001054 dimerization interface [polypeptide binding]; other site 243160001055 active site 243160001056 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160001057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160001058 Walker A motif; other site 243160001059 ATP binding site [chemical binding]; other site 243160001060 Walker B motif; other site 243160001061 arginine finger; other site 243160001062 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160001063 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160001064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160001065 Walker A motif; other site 243160001066 ATP binding site [chemical binding]; other site 243160001067 Walker B motif; other site 243160001068 arginine finger; other site 243160001069 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243160001070 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 243160001071 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243160001072 folate binding site [chemical binding]; other site 243160001073 NADP+ binding site [chemical binding]; other site 243160001074 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001075 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001076 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001077 peptidase PmbA; Provisional; Region: PRK11040 243160001078 hypothetical protein; Provisional; Region: PRK05255 243160001079 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243160001080 MPT binding site; other site 243160001081 trimer interface [polypeptide binding]; other site 243160001082 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 243160001083 catalytic site [active] 243160001084 putative active site [active] 243160001085 putative substrate binding site [chemical binding]; other site 243160001086 dimer interface [polypeptide binding]; other site 243160001087 Peptidase family M48; Region: Peptidase_M48; pfam01435 243160001088 GTPase RsgA; Reviewed; Region: PRK00098 243160001089 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 243160001090 RNA binding site [nucleotide binding]; other site 243160001091 homodimer interface [polypeptide binding]; other site 243160001092 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243160001093 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243160001094 GTP/Mg2+ binding site [chemical binding]; other site 243160001095 G4 box; other site 243160001096 G5 box; other site 243160001097 G1 box; other site 243160001098 Switch I region; other site 243160001099 G2 box; other site 243160001100 G3 box; other site 243160001101 Switch II region; other site 243160001102 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 243160001103 CobD/CbiB family protein; Provisional; Region: PRK07630 243160001104 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 243160001105 putative active site [active] 243160001106 putative CoA binding site [chemical binding]; other site 243160001107 nudix motif; other site 243160001108 metal binding site [ion binding]; metal-binding site 243160001109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160001110 Coenzyme A binding pocket [chemical binding]; other site 243160001111 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243160001112 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243160001113 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 243160001114 RimM N-terminal domain; Region: RimM; pfam01782 243160001115 PRC-barrel domain; Region: PRC; pfam05239 243160001116 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 243160001117 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 243160001118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160001119 FeS/SAM binding site; other site 243160001120 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 243160001121 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243160001122 AsnC family; Region: AsnC_trans_reg; pfam01037 243160001123 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 243160001124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160001125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243160001126 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 243160001127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 243160001128 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 243160001129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 243160001130 Ligand binding site [chemical binding]; other site 243160001131 Electron transfer flavoprotein domain; Region: ETF; pfam01012 243160001132 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 243160001133 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 243160001134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160001135 dimer interface [polypeptide binding]; other site 243160001136 conserved gate region; other site 243160001137 ABC-ATPase subunit interface; other site 243160001138 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 243160001139 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 243160001140 Walker A/P-loop; other site 243160001141 ATP binding site [chemical binding]; other site 243160001142 Q-loop/lid; other site 243160001143 ABC transporter signature motif; other site 243160001144 Walker B; other site 243160001145 D-loop; other site 243160001146 H-loop/switch region; other site 243160001147 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 243160001148 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 243160001149 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160001150 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243160001151 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 243160001152 putative active site [active] 243160001153 Zn binding site [ion binding]; other site 243160001154 Transglycosylase SLT domain; Region: SLT_2; pfam13406 243160001155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160001156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160001157 catalytic residue [active] 243160001158 cysteine synthase B; Region: cysM; TIGR01138 243160001159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243160001160 dimer interface [polypeptide binding]; other site 243160001161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160001162 catalytic residue [active] 243160001163 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 243160001164 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 243160001165 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 243160001166 NADP binding site [chemical binding]; other site 243160001167 homopentamer interface [polypeptide binding]; other site 243160001168 substrate binding site [chemical binding]; other site 243160001169 active site 243160001170 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 243160001171 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160001172 putative ribose interaction site [chemical binding]; other site 243160001173 putative ADP binding site [chemical binding]; other site 243160001174 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243160001175 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243160001176 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243160001177 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243160001178 tetratricopeptide repeat protein; Provisional; Region: PRK11788 243160001179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160001180 binding surface 243160001181 TPR motif; other site 243160001182 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 243160001183 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001185 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001186 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243160001187 IHF dimer interface [polypeptide binding]; other site 243160001188 IHF - DNA interface [nucleotide binding]; other site 243160001189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 243160001190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 243160001191 RNA binding site [nucleotide binding]; other site 243160001192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243160001193 RNA binding site [nucleotide binding]; other site 243160001194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243160001195 RNA binding site [nucleotide binding]; other site 243160001196 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 243160001197 RNA binding site [nucleotide binding]; other site 243160001198 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 243160001199 RNA binding site [nucleotide binding]; other site 243160001200 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 243160001201 RNA binding site [nucleotide binding]; other site 243160001202 cytidylate kinase; Provisional; Region: cmk; PRK00023 243160001203 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243160001204 CMP-binding site; other site 243160001205 The sites determining sugar specificity; other site 243160001206 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 243160001207 prephenate dehydrogenase; Validated; Region: PRK08507 243160001208 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243160001209 hinge; other site 243160001210 active site 243160001211 Chorismate mutase type II; Region: CM_2; smart00830 243160001212 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 243160001213 Prephenate dehydratase; Region: PDT; pfam00800 243160001214 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243160001215 putative L-Phe binding site [chemical binding]; other site 243160001216 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 243160001217 homodimer interface [polypeptide binding]; other site 243160001218 substrate-cofactor binding pocket; other site 243160001219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160001220 catalytic residue [active] 243160001221 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 243160001222 DNA gyrase subunit A; Validated; Region: PRK05560 243160001223 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243160001224 CAP-like domain; other site 243160001225 active site 243160001226 primary dimer interface [polypeptide binding]; other site 243160001227 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001228 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001229 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001230 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001231 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243160001233 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160001234 ligand binding site [chemical binding]; other site 243160001235 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 243160001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160001237 S-adenosylmethionine binding site [chemical binding]; other site 243160001238 phosphoglycolate phosphatase; Provisional; Region: PRK13226 243160001239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160001240 motif II; other site 243160001241 HTH-like domain; Region: HTH_21; pfam13276 243160001242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001243 Integrase core domain; Region: rve; pfam00665 243160001244 Integrase core domain; Region: rve_3; pfam13683 243160001245 Transposase; Region: HTH_Tnp_1; pfam01527 243160001246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160001247 S-adenosylmethionine binding site [chemical binding]; other site 243160001248 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 243160001249 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 243160001250 PBP superfamily domain; Region: PBP_like; pfam12727 243160001251 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 243160001252 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 243160001253 putative dimer interface [polypeptide binding]; other site 243160001254 [2Fe-2S] cluster binding site [ion binding]; other site 243160001255 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 243160001256 putative dimer interface [polypeptide binding]; other site 243160001257 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243160001258 SLBB domain; Region: SLBB; pfam10531 243160001259 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243160001260 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 243160001261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160001262 catalytic loop [active] 243160001263 iron binding site [ion binding]; other site 243160001264 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 243160001265 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 243160001266 [4Fe-4S] binding site [ion binding]; other site 243160001267 molybdopterin cofactor binding site; other site 243160001268 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 243160001269 molybdopterin cofactor binding site; other site 243160001270 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 243160001271 hypothetical protein; Provisional; Region: PRK06184 243160001272 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243160001273 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 243160001274 TPR repeat; Region: TPR_11; pfam13414 243160001275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160001276 binding surface 243160001277 TPR motif; other site 243160001278 TPR repeat; Region: TPR_11; pfam13414 243160001279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160001280 TPR repeat; Region: TPR_11; pfam13414 243160001281 TPR motif; other site 243160001282 binding surface 243160001283 TPR repeat; Region: TPR_11; pfam13414 243160001284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160001285 binding surface 243160001286 TPR motif; other site 243160001287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160001288 citrate-proton symporter; Provisional; Region: PRK15075 243160001289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160001290 putative substrate translocation pore; other site 243160001291 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 243160001292 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 243160001293 catalytic triad [active] 243160001294 amidase; Provisional; Region: PRK07056 243160001295 Amidase; Region: Amidase; cl11426 243160001296 disulfide bond formation protein B; Provisional; Region: PRK02110 243160001297 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 243160001298 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 243160001299 XdhC Rossmann domain; Region: XdhC_C; pfam13478 243160001300 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 243160001301 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 243160001302 active site 243160001303 purine riboside binding site [chemical binding]; other site 243160001304 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 243160001305 guanine deaminase; Provisional; Region: PRK09228 243160001306 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160001307 active site 243160001308 Predicted membrane protein [Function unknown]; Region: COG2119 243160001309 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243160001310 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243160001311 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 243160001312 aminopeptidase N; Provisional; Region: pepN; PRK14015 243160001313 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 243160001314 active site 243160001315 Zn binding site [ion binding]; other site 243160001316 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 243160001317 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 243160001318 THF binding site; other site 243160001319 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 243160001320 substrate binding site [chemical binding]; other site 243160001321 THF binding site; other site 243160001322 zinc-binding site [ion binding]; other site 243160001323 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 243160001324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160001325 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 243160001326 putative dimerization interface [polypeptide binding]; other site 243160001327 fructose-1,6-bisphosphatase family protein; Region: PLN02628 243160001328 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 243160001329 AMP binding site [chemical binding]; other site 243160001330 metal binding site [ion binding]; metal-binding site 243160001331 active site 243160001332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160001333 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160001334 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243160001335 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160001336 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243160001337 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160001338 N-terminal plug; other site 243160001339 ligand-binding site [chemical binding]; other site 243160001340 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 243160001341 chorismate mutase; Provisional; Region: PRK09269 243160001342 Chorismate mutase type II; Region: CM_2; cl00693 243160001343 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 243160001344 HTH-like domain; Region: HTH_21; pfam13276 243160001345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001346 Integrase core domain; Region: rve; pfam00665 243160001347 Integrase core domain; Region: rve_3; pfam13683 243160001348 Transposase; Region: HTH_Tnp_1; pfam01527 243160001349 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243160001350 pseudouridine synthase; Region: TIGR00093 243160001351 active site 243160001352 isocitrate dehydrogenase; Validated; Region: PRK07362 243160001353 isocitrate dehydrogenase; Reviewed; Region: PRK07006 243160001354 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 243160001355 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243160001356 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243160001357 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001359 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160001361 dimerization interface [polypeptide binding]; other site 243160001362 putative DNA binding site [nucleotide binding]; other site 243160001363 putative Zn2+ binding site [ion binding]; other site 243160001364 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 243160001365 fumarate hydratase; Reviewed; Region: fumC; PRK00485 243160001366 Class II fumarases; Region: Fumarase_classII; cd01362 243160001367 active site 243160001368 tetramer interface [polypeptide binding]; other site 243160001369 HTH-like domain; Region: HTH_21; pfam13276 243160001370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001371 Integrase core domain; Region: rve; pfam00665 243160001372 Integrase core domain; Region: rve_3; pfam13683 243160001373 Transposase; Region: HTH_Tnp_1; pfam01527 243160001374 HTH-like domain; Region: HTH_21; pfam13276 243160001375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001376 Integrase core domain; Region: rve; pfam00665 243160001377 Integrase core domain; Region: rve_3; pfam13683 243160001378 Transposase; Region: HTH_Tnp_1; pfam01527 243160001379 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 243160001380 multidrug efflux protein; Reviewed; Region: PRK01766 243160001381 cation binding site [ion binding]; other site 243160001382 S4 domain; Region: S4_2; pfam13275 243160001383 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 243160001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 243160001385 CreA protein; Region: CreA; pfam05981 243160001386 Ferredoxin [Energy production and conversion]; Region: COG1146 243160001387 4Fe-4S binding domain; Region: Fer4; cl02805 243160001388 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243160001389 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 243160001390 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 243160001391 active site 243160001392 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 243160001393 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243160001394 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 243160001395 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243160001396 dimerization interface [polypeptide binding]; other site 243160001397 ligand binding site [chemical binding]; other site 243160001398 NADP binding site [chemical binding]; other site 243160001399 catalytic site [active] 243160001400 RmuC family; Region: RmuC; pfam02646 243160001401 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243160001402 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243160001403 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243160001404 dimer interface [polypeptide binding]; other site 243160001405 putative functional site; other site 243160001406 putative MPT binding site; other site 243160001407 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 243160001408 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243160001409 GTP binding site; other site 243160001410 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 243160001411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160001412 FeS/SAM binding site; other site 243160001413 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243160001414 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 243160001415 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243160001416 homodimer interface [polypeptide binding]; other site 243160001417 oligonucleotide binding site [chemical binding]; other site 243160001418 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 243160001419 S4 domain; Region: S4; pfam01479 243160001420 RNA binding surface [nucleotide binding]; other site 243160001421 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243160001422 active site 243160001423 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243160001424 iron-sulfur cluster [ion binding]; other site 243160001425 [2Fe-2S] cluster binding site [ion binding]; other site 243160001426 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243160001427 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 243160001428 tandem repeat interface [polypeptide binding]; other site 243160001429 oligomer interface [polypeptide binding]; other site 243160001430 active site residues [active] 243160001431 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 243160001432 putative SAM binding site [chemical binding]; other site 243160001433 homodimer interface [polypeptide binding]; other site 243160001434 Maf-like protein; Region: Maf; pfam02545 243160001435 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243160001436 active site 243160001437 dimer interface [polypeptide binding]; other site 243160001438 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 243160001439 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 243160001440 putative phosphate acyltransferase; Provisional; Region: PRK05331 243160001441 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243160001442 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243160001443 dimer interface [polypeptide binding]; other site 243160001444 active site 243160001445 CoA binding pocket [chemical binding]; other site 243160001446 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243160001447 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243160001448 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243160001449 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 243160001450 NAD(P) binding site [chemical binding]; other site 243160001451 homotetramer interface [polypeptide binding]; other site 243160001452 homodimer interface [polypeptide binding]; other site 243160001453 active site 243160001454 acyl carrier protein; Provisional; Region: acpP; PRK00982 243160001455 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 243160001456 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243160001457 dimer interface [polypeptide binding]; other site 243160001458 active site 243160001459 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 243160001460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160001461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160001462 DNA binding residues [nucleotide binding] 243160001463 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 243160001464 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 243160001465 anti-sigma E factor; Provisional; Region: rseB; PRK09455 243160001466 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243160001467 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243160001468 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160001469 protein binding site [polypeptide binding]; other site 243160001470 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160001471 protein binding site [polypeptide binding]; other site 243160001472 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 243160001473 GTP-binding protein LepA; Provisional; Region: PRK05433 243160001474 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243160001475 G1 box; other site 243160001476 putative GEF interaction site [polypeptide binding]; other site 243160001477 GTP/Mg2+ binding site [chemical binding]; other site 243160001478 Switch I region; other site 243160001479 G2 box; other site 243160001480 G3 box; other site 243160001481 Switch II region; other site 243160001482 G4 box; other site 243160001483 G5 box; other site 243160001484 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243160001485 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243160001486 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243160001487 signal peptidase I; Provisional; Region: PRK10861 243160001488 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243160001489 Catalytic site [active] 243160001490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243160001491 ribonuclease III; Provisional; Region: PRK14718 243160001492 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243160001493 dimerization interface [polypeptide binding]; other site 243160001494 active site 243160001495 metal binding site [ion binding]; metal-binding site 243160001496 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243160001497 GTPase Era; Reviewed; Region: era; PRK00089 243160001498 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 243160001499 G1 box; other site 243160001500 GTP/Mg2+ binding site [chemical binding]; other site 243160001501 Switch I region; other site 243160001502 G2 box; other site 243160001503 Switch II region; other site 243160001504 G3 box; other site 243160001505 G4 box; other site 243160001506 G5 box; other site 243160001507 KH domain; Region: KH_2; pfam07650 243160001508 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 243160001509 Recombination protein O N terminal; Region: RecO_N; pfam11967 243160001510 Recombination protein O C terminal; Region: RecO_C; pfam02565 243160001511 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 243160001512 active site 243160001513 hydrophilic channel; other site 243160001514 dimerization interface [polypeptide binding]; other site 243160001515 catalytic residues [active] 243160001516 active site lid [active] 243160001517 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 243160001518 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 243160001519 beta-hexosaminidase; Provisional; Region: PRK05337 243160001520 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160001521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160001522 active site 243160001523 phosphorylation site [posttranslational modification] 243160001524 intermolecular recognition site; other site 243160001525 dimerization interface [polypeptide binding]; other site 243160001526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160001527 Walker A motif; other site 243160001528 ATP binding site [chemical binding]; other site 243160001529 Walker B motif; other site 243160001530 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160001531 elongation factor P; Validated; Region: PRK00529 243160001532 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243160001533 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243160001534 RNA binding site [nucleotide binding]; other site 243160001535 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243160001536 RNA binding site [nucleotide binding]; other site 243160001537 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 243160001538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 243160001539 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243160001540 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243160001541 GIY-YIG motif/motif A; other site 243160001542 active site 243160001543 catalytic site [active] 243160001544 putative DNA binding site [nucleotide binding]; other site 243160001545 metal binding site [ion binding]; metal-binding site 243160001546 UvrB/uvrC motif; Region: UVR; pfam02151 243160001547 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243160001548 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243160001549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 243160001550 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243160001551 LysR family transcriptional regulator; Provisional; Region: PRK14997 243160001552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160001553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 243160001554 putative effector binding pocket; other site 243160001555 putative dimerization interface [polypeptide binding]; other site 243160001556 Pirin-related protein [General function prediction only]; Region: COG1741 243160001557 Pirin; Region: Pirin; pfam02678 243160001558 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243160001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160001560 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 243160001561 Protein of unknown function (DUF461); Region: DUF461; pfam04314 243160001562 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 243160001563 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243160001564 Cu(I) binding site [ion binding]; other site 243160001565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160001566 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 243160001567 active site 243160001568 motif I; other site 243160001569 motif II; other site 243160001570 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 243160001571 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 243160001572 active site 243160001573 homotetramer interface [polypeptide binding]; other site 243160001574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243160001575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160001576 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243160001577 Walker A/P-loop; other site 243160001578 ATP binding site [chemical binding]; other site 243160001579 Q-loop/lid; other site 243160001580 ABC transporter signature motif; other site 243160001581 Walker B; other site 243160001582 D-loop; other site 243160001583 H-loop/switch region; other site 243160001584 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243160001585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160001586 putative ADP-binding pocket [chemical binding]; other site 243160001587 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 243160001588 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243160001589 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160001590 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 243160001591 dimerization interface [polypeptide binding]; other site 243160001592 ligand binding site [chemical binding]; other site 243160001593 HTH-like domain; Region: HTH_21; pfam13276 243160001594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001595 Integrase core domain; Region: rve; pfam00665 243160001596 Integrase core domain; Region: rve_3; pfam13683 243160001597 Transposase; Region: HTH_Tnp_1; pfam01527 243160001598 putative membrane protein; Region: HpnL; TIGR03476 243160001599 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 243160001600 putative active site [active] 243160001601 YdjC motif; other site 243160001602 Mg binding site [ion binding]; other site 243160001603 putative homodimer interface [polypeptide binding]; other site 243160001604 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 243160001605 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243160001606 B12 binding site [chemical binding]; other site 243160001607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160001608 FeS/SAM binding site; other site 243160001609 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 243160001610 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 243160001611 ligand binding site; other site 243160001612 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 243160001613 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243160001614 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 243160001615 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160001616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160001617 pyridoxamine kinase; Validated; Region: PRK05756 243160001618 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 243160001619 dimer interface [polypeptide binding]; other site 243160001620 pyridoxal binding site [chemical binding]; other site 243160001621 ATP binding site [chemical binding]; other site 243160001622 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 243160001623 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243160001624 Domain of unknown function (DUF756); Region: DUF756; pfam05506 243160001625 Domain of unknown function (DUF756); Region: DUF756; pfam05506 243160001626 Transposase; Region: HTH_Tnp_1; pfam01527 243160001627 HTH-like domain; Region: HTH_21; pfam13276 243160001628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001629 Integrase core domain; Region: rve; pfam00665 243160001630 Integrase core domain; Region: rve_3; pfam13683 243160001631 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160001632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160001633 dimer interface [polypeptide binding]; other site 243160001634 conserved gate region; other site 243160001635 putative PBP binding loops; other site 243160001636 ABC-ATPase subunit interface; other site 243160001637 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 243160001638 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160001639 Walker A/P-loop; other site 243160001640 ATP binding site [chemical binding]; other site 243160001641 Q-loop/lid; other site 243160001642 ABC transporter signature motif; other site 243160001643 Walker B; other site 243160001644 D-loop; other site 243160001645 H-loop/switch region; other site 243160001646 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160001647 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 243160001648 conserved cys residue [active] 243160001649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160001650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160001651 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 243160001652 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160001653 inhibitor-cofactor binding pocket; inhibition site 243160001654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160001655 catalytic residue [active] 243160001656 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 243160001657 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 243160001658 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 243160001659 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 243160001660 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 243160001661 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 243160001662 NAD(P) binding site [chemical binding]; other site 243160001663 catalytic residues [active] 243160001664 succinylarginine dihydrolase; Provisional; Region: PRK13281 243160001665 succinylglutamate desuccinylase; Provisional; Region: PRK05324 243160001666 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 243160001667 active site 243160001668 Zn binding site [ion binding]; other site 243160001669 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 243160001670 dimer interface [polypeptide binding]; other site 243160001671 N-terminal domain interface [polypeptide binding]; other site 243160001672 substrate binding pocket (H-site) [chemical binding]; other site 243160001673 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 243160001674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160001675 substrate binding pocket [chemical binding]; other site 243160001676 membrane-bound complex binding site; other site 243160001677 hinge residues; other site 243160001678 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243160001679 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 243160001680 putative di-iron ligands [ion binding]; other site 243160001681 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 243160001682 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 243160001683 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243160001684 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 243160001685 Hemerythrin; Region: Hemerythrin; cd12107 243160001686 Fe binding site [ion binding]; other site 243160001687 Transcriptional regulator; Region: Rrf2; cl17282 243160001688 Rrf2 family protein; Region: rrf2_super; TIGR00738 243160001689 Domain of unknown function DUF59; Region: DUF59; cl00941 243160001690 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243160001691 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243160001692 trimerization site [polypeptide binding]; other site 243160001693 active site 243160001694 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243160001695 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243160001696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160001697 catalytic residue [active] 243160001698 FeS assembly protein SufD; Region: sufD; TIGR01981 243160001699 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 243160001700 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 243160001701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160001702 Walker A/P-loop; other site 243160001703 ATP binding site [chemical binding]; other site 243160001704 ABC transporter signature motif; other site 243160001705 Walker B; other site 243160001706 D-loop; other site 243160001707 H-loop/switch region; other site 243160001708 NnrS protein; Region: NnrS; pfam05940 243160001709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160001710 dimerization interface [polypeptide binding]; other site 243160001711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160001712 dimer interface [polypeptide binding]; other site 243160001713 putative CheW interface [polypeptide binding]; other site 243160001714 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 243160001715 HemN C-terminal domain; Region: HemN_C; pfam06969 243160001716 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243160001717 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160001718 ligand binding site [chemical binding]; other site 243160001719 flexible hinge region; other site 243160001720 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 243160001721 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 243160001722 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243160001723 FMN binding site [chemical binding]; other site 243160001724 substrate binding site [chemical binding]; other site 243160001725 putative catalytic residue [active] 243160001726 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243160001727 Peptidase family U32; Region: Peptidase_U32; pfam01136 243160001728 putative protease; Provisional; Region: PRK15447 243160001729 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243160001730 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 243160001731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160001732 FeS/SAM binding site; other site 243160001733 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 243160001734 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 243160001735 Class III ribonucleotide reductase; Region: RNR_III; cd01675 243160001736 effector binding site; other site 243160001737 active site 243160001738 Zn binding site [ion binding]; other site 243160001739 NnrS protein; Region: NnrS; pfam05940 243160001740 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 243160001741 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 243160001742 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 243160001743 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243160001744 Di-iron ligands [ion binding]; other site 243160001745 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 243160001746 DNA photolyase; Region: DNA_photolyase; pfam00875 243160001747 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243160001748 ligand-binding site [chemical binding]; other site 243160001749 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 243160001750 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160001751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160001752 DNA binding residues [nucleotide binding] 243160001753 dimerization interface [polypeptide binding]; other site 243160001754 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 243160001755 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 243160001756 active sites [active] 243160001757 tetramer interface [polypeptide binding]; other site 243160001758 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 243160001759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160001760 DNA-binding site [nucleotide binding]; DNA binding site 243160001761 UTRA domain; Region: UTRA; pfam07702 243160001762 urocanate hydratase; Provisional; Region: PRK05414 243160001763 HutD; Region: HutD; pfam05962 243160001764 imidazolonepropionase; Validated; Region: PRK09356 243160001765 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 243160001766 active site 243160001767 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 243160001768 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 243160001769 active site 243160001770 N-formylglutamate amidohydrolase; Region: FGase; cl01522 243160001771 Peptidase C26; Region: Peptidase_C26; pfam07722 243160001772 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 243160001773 catalytic triad [active] 243160001774 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 243160001775 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243160001776 HTH-like domain; Region: HTH_21; pfam13276 243160001777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001778 Integrase core domain; Region: rve; pfam00665 243160001779 Integrase core domain; Region: rve_3; pfam13683 243160001780 Transposase; Region: HTH_Tnp_1; pfam01527 243160001781 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 243160001782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160001783 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 243160001784 substrate binding site [chemical binding]; other site 243160001785 dimerization interface [polypeptide binding]; other site 243160001786 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 243160001787 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160001788 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160001789 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 243160001790 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243160001791 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243160001792 Active Sites [active] 243160001793 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243160001794 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243160001795 Active Sites [active] 243160001796 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 243160001797 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243160001798 CysD dimerization site [polypeptide binding]; other site 243160001799 G1 box; other site 243160001800 putative GEF interaction site [polypeptide binding]; other site 243160001801 GTP/Mg2+ binding site [chemical binding]; other site 243160001802 Switch I region; other site 243160001803 G2 box; other site 243160001804 G3 box; other site 243160001805 Switch II region; other site 243160001806 G4 box; other site 243160001807 G5 box; other site 243160001808 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243160001809 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243160001810 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243160001811 active site 243160001812 SAM binding site [chemical binding]; other site 243160001813 homodimer interface [polypeptide binding]; other site 243160001814 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243160001815 putative active site [active] 243160001816 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 243160001817 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243160001818 Predicted permeases [General function prediction only]; Region: COG0795 243160001819 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243160001820 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243160001821 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243160001822 interface (dimer of trimers) [polypeptide binding]; other site 243160001823 Substrate-binding/catalytic site; other site 243160001824 Zn-binding sites [ion binding]; other site 243160001825 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 243160001826 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 243160001827 Cytochrome c; Region: Cytochrom_C; cl11414 243160001828 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001829 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001830 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001831 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243160001832 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 243160001833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160001834 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 243160001835 putative dimerization interface [polypeptide binding]; other site 243160001836 putative substrate binding pocket [chemical binding]; other site 243160001837 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 243160001838 Protein of unknown function (DUF541); Region: SIMPL; cl01077 243160001839 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 243160001840 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160001841 N-terminal plug; other site 243160001842 ligand-binding site [chemical binding]; other site 243160001843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243160001844 ABC-ATPase subunit interface; other site 243160001845 dimer interface [polypeptide binding]; other site 243160001846 putative PBP binding regions; other site 243160001847 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 243160001848 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 243160001849 Walker A/P-loop; other site 243160001850 ATP binding site [chemical binding]; other site 243160001851 Q-loop/lid; other site 243160001852 ABC transporter signature motif; other site 243160001853 Walker B; other site 243160001854 D-loop; other site 243160001855 H-loop/switch region; other site 243160001856 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 243160001857 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 243160001858 putative dimer interface [polypeptide binding]; other site 243160001859 active site pocket [active] 243160001860 putative cataytic base [active] 243160001861 cobalamin synthase; Reviewed; Region: cobS; PRK00235 243160001862 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160001863 catalytic core [active] 243160001864 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 243160001865 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 243160001866 cobalamin binding residues [chemical binding]; other site 243160001867 putative BtuC binding residues; other site 243160001868 dimer interface [polypeptide binding]; other site 243160001869 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 243160001870 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 243160001871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160001872 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 243160001873 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 243160001874 homotrimer interface [polypeptide binding]; other site 243160001875 Walker A motif; other site 243160001876 GTP binding site [chemical binding]; other site 243160001877 Walker B motif; other site 243160001878 cobyric acid synthase; Provisional; Region: PRK00784 243160001879 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 243160001880 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 243160001881 catalytic triad [active] 243160001882 DoxX; Region: DoxX; pfam07681 243160001883 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243160001884 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243160001885 P-loop; other site 243160001886 Magnesium ion binding site [ion binding]; other site 243160001887 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 243160001888 tetramerization interface [polypeptide binding]; other site 243160001889 active site 243160001890 pantoate--beta-alanine ligase; Region: panC; TIGR00018 243160001891 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243160001892 active site 243160001893 ATP-binding site [chemical binding]; other site 243160001894 pantoate-binding site; other site 243160001895 HXXH motif; other site 243160001896 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 243160001897 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 243160001898 Surface antigen; Region: Bac_surface_Ag; pfam01103 243160001899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 243160001900 Family of unknown function (DUF490); Region: DUF490; pfam04357 243160001901 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 243160001902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160001903 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 243160001904 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243160001905 active site 243160001906 HIGH motif; other site 243160001907 KMSKS motif; other site 243160001908 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243160001909 tRNA binding surface [nucleotide binding]; other site 243160001910 anticodon binding site; other site 243160001911 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 243160001912 dimer interface [polypeptide binding]; other site 243160001913 putative tRNA-binding site [nucleotide binding]; other site 243160001914 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243160001915 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160001916 ligand binding site [chemical binding]; other site 243160001917 Domain of unknown function DUF59; Region: DUF59; pfam01883 243160001918 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243160001919 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 243160001920 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 243160001921 E-class dimer interface [polypeptide binding]; other site 243160001922 P-class dimer interface [polypeptide binding]; other site 243160001923 active site 243160001924 Cu2+ binding site [ion binding]; other site 243160001925 Zn2+ binding site [ion binding]; other site 243160001926 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243160001927 trimer interface [polypeptide binding]; other site 243160001928 active site 243160001929 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 243160001930 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 243160001931 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160001932 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160001933 catalytic residue [active] 243160001934 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 243160001935 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 243160001936 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 243160001937 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243160001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160001939 motif II; other site 243160001940 argininosuccinate lyase; Provisional; Region: PRK00855 243160001941 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243160001942 active sites [active] 243160001943 tetramer interface [polypeptide binding]; other site 243160001944 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 243160001945 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 243160001946 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 243160001947 PapC C-terminal domain; Region: PapC_C; pfam13953 243160001948 Transposase; Region: HTH_Tnp_1; pfam01527 243160001949 HTH-like domain; Region: HTH_21; pfam13276 243160001950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160001951 Integrase core domain; Region: rve; pfam00665 243160001952 Integrase core domain; Region: rve_3; pfam13683 243160001953 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 243160001954 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 243160001955 Spore Coat Protein U domain; Region: SCPU; pfam05229 243160001956 Spore Coat Protein U domain; Region: SCPU; pfam05229 243160001957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160001958 sequence-specific DNA binding site [nucleotide binding]; other site 243160001959 salt bridge; other site 243160001960 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160001961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160001962 S-adenosylmethionine binding site [chemical binding]; other site 243160001963 Transposase domain (DUF772); Region: DUF772; pfam05598 243160001964 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160001965 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160001966 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 243160001967 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 243160001968 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243160001969 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 243160001970 domain interfaces; other site 243160001971 active site 243160001972 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 243160001973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243160001974 active site 243160001975 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 243160001976 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 243160001977 HemY protein N-terminus; Region: HemY_N; pfam07219 243160001978 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 243160001979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160001980 putative substrate translocation pore; other site 243160001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160001982 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243160001983 NAD(P) binding site [chemical binding]; other site 243160001984 active site 243160001985 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160001986 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 243160001987 NAD(P) binding site [chemical binding]; other site 243160001988 catalytic residues [active] 243160001989 catalytic residues [active] 243160001990 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 243160001991 dimer interface [polypeptide binding]; other site 243160001992 substrate binding site [chemical binding]; other site 243160001993 metal binding sites [ion binding]; metal-binding site 243160001994 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 243160001995 GIY-YIG motif/motif A; other site 243160001996 putative active site [active] 243160001997 putative metal binding site [ion binding]; other site 243160001998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 243160001999 Protein of unknown function, DUF482; Region: DUF482; pfam04339 243160002000 NAD synthetase; Provisional; Region: PRK13981 243160002001 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 243160002002 multimer interface [polypeptide binding]; other site 243160002003 active site 243160002004 catalytic triad [active] 243160002005 protein interface 1 [polypeptide binding]; other site 243160002006 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243160002007 homodimer interface [polypeptide binding]; other site 243160002008 NAD binding pocket [chemical binding]; other site 243160002009 ATP binding pocket [chemical binding]; other site 243160002010 Mg binding site [ion binding]; other site 243160002011 active-site loop [active] 243160002012 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243160002013 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243160002014 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160002015 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160002016 trimer interface [polypeptide binding]; other site 243160002017 eyelet of channel; other site 243160002018 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 243160002019 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160002020 Walker A/P-loop; other site 243160002021 ATP binding site [chemical binding]; other site 243160002022 Q-loop/lid; other site 243160002023 ABC transporter signature motif; other site 243160002024 Walker B; other site 243160002025 D-loop; other site 243160002026 H-loop/switch region; other site 243160002027 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002029 dimer interface [polypeptide binding]; other site 243160002030 conserved gate region; other site 243160002031 putative PBP binding loops; other site 243160002032 ABC-ATPase subunit interface; other site 243160002033 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 243160002034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160002035 substrate binding pocket [chemical binding]; other site 243160002036 membrane-bound complex binding site; other site 243160002037 hinge residues; other site 243160002038 osmolarity response regulator; Provisional; Region: ompR; PRK09468 243160002039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002040 active site 243160002041 phosphorylation site [posttranslational modification] 243160002042 intermolecular recognition site; other site 243160002043 dimerization interface [polypeptide binding]; other site 243160002044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160002045 DNA binding site [nucleotide binding] 243160002046 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 243160002047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160002048 dimer interface [polypeptide binding]; other site 243160002049 phosphorylation site [posttranslational modification] 243160002050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160002051 ATP binding site [chemical binding]; other site 243160002052 Mg2+ binding site [ion binding]; other site 243160002053 G-X-G motif; other site 243160002054 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 243160002055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002056 dimer interface [polypeptide binding]; other site 243160002057 conserved gate region; other site 243160002058 putative PBP binding loops; other site 243160002059 ABC-ATPase subunit interface; other site 243160002060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002061 dimer interface [polypeptide binding]; other site 243160002062 conserved gate region; other site 243160002063 putative PBP binding loops; other site 243160002064 ABC-ATPase subunit interface; other site 243160002065 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243160002066 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243160002067 Walker A/P-loop; other site 243160002068 ATP binding site [chemical binding]; other site 243160002069 Q-loop/lid; other site 243160002070 ABC transporter signature motif; other site 243160002071 Walker B; other site 243160002072 D-loop; other site 243160002073 H-loop/switch region; other site 243160002074 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 243160002075 HTH-like domain; Region: HTH_21; pfam13276 243160002076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002077 Integrase core domain; Region: rve; pfam00665 243160002078 Integrase core domain; Region: rve_3; pfam13683 243160002079 Transposase; Region: HTH_Tnp_1; pfam01527 243160002080 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243160002081 N-terminal domain interface [polypeptide binding]; other site 243160002082 proline/glycine betaine transporter; Provisional; Region: PRK10642 243160002083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002084 putative substrate translocation pore; other site 243160002085 hypothetical protein; Provisional; Region: PRK02237 243160002086 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 243160002087 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 243160002088 active site 243160002089 catalytic site [active] 243160002090 substrate binding site [chemical binding]; other site 243160002091 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243160002092 RNA/DNA hybrid binding site [nucleotide binding]; other site 243160002093 active site 243160002094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160002095 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 243160002096 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 243160002097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160002098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160002099 catalytic residue [active] 243160002100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 243160002101 Lysin motif; Region: LysM; smart00257 243160002102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160002104 putative substrate translocation pore; other site 243160002105 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 243160002106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160002107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160002108 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243160002109 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 243160002110 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243160002111 catalytic site [active] 243160002112 subunit interface [polypeptide binding]; other site 243160002113 leucine export protein LeuE; Provisional; Region: PRK10958 243160002114 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243160002115 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243160002116 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243160002117 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 243160002118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243160002119 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243160002120 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243160002121 IMP binding site; other site 243160002122 dimer interface [polypeptide binding]; other site 243160002123 interdomain contacts; other site 243160002124 partial ornithine binding site; other site 243160002125 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243160002126 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243160002127 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243160002128 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 243160002129 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 243160002130 FtsJ-like methyltransferase; Region: FtsJ; cl17430 243160002131 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 243160002132 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 243160002133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160002134 Walker A motif; other site 243160002135 ATP binding site [chemical binding]; other site 243160002136 Walker B motif; other site 243160002137 arginine finger; other site 243160002138 Peptidase family M41; Region: Peptidase_M41; pfam01434 243160002139 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243160002140 dihydropteroate synthase; Region: DHPS; TIGR01496 243160002141 substrate binding pocket [chemical binding]; other site 243160002142 dimer interface [polypeptide binding]; other site 243160002143 inhibitor binding site; inhibition site 243160002144 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 243160002145 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 243160002146 active site 243160002147 substrate binding site [chemical binding]; other site 243160002148 metal binding site [ion binding]; metal-binding site 243160002149 PBP superfamily domain; Region: PBP_like_2; cl17296 243160002150 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 243160002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002152 dimer interface [polypeptide binding]; other site 243160002153 conserved gate region; other site 243160002154 putative PBP binding loops; other site 243160002155 ABC-ATPase subunit interface; other site 243160002156 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 243160002157 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243160002158 Walker A/P-loop; other site 243160002159 ATP binding site [chemical binding]; other site 243160002160 Q-loop/lid; other site 243160002161 ABC transporter signature motif; other site 243160002162 Walker B; other site 243160002163 D-loop; other site 243160002164 H-loop/switch region; other site 243160002165 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243160002166 PhoU domain; Region: PhoU; pfam01895 243160002167 PhoU domain; Region: PhoU; pfam01895 243160002168 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 243160002169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002170 active site 243160002171 phosphorylation site [posttranslational modification] 243160002172 intermolecular recognition site; other site 243160002173 dimerization interface [polypeptide binding]; other site 243160002174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160002175 DNA binding site [nucleotide binding] 243160002176 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243160002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160002178 dimer interface [polypeptide binding]; other site 243160002179 phosphorylation site [posttranslational modification] 243160002180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160002181 ATP binding site [chemical binding]; other site 243160002182 Mg2+ binding site [ion binding]; other site 243160002183 G-X-G motif; other site 243160002184 polyphosphate kinase; Provisional; Region: PRK05443 243160002185 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243160002186 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243160002187 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243160002188 putative active site [active] 243160002189 catalytic site [active] 243160002190 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 243160002191 putative domain interface [polypeptide binding]; other site 243160002192 putative active site [active] 243160002193 catalytic site [active] 243160002194 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 243160002195 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 243160002196 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243160002197 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 243160002198 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 243160002199 catalytic core [active] 243160002200 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 243160002201 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 243160002202 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 243160002203 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 243160002204 active site 243160002205 acyl-activating enzyme (AAE) consensus motif; other site 243160002206 putative CoA binding site [chemical binding]; other site 243160002207 AMP binding site [chemical binding]; other site 243160002208 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243160002209 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 243160002210 Peptidase family M23; Region: Peptidase_M23; pfam01551 243160002211 Transposase; Region: HTH_Tnp_1; pfam01527 243160002212 HTH-like domain; Region: HTH_21; pfam13276 243160002213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002214 Integrase core domain; Region: rve; pfam00665 243160002215 Integrase core domain; Region: rve_3; pfam13683 243160002216 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 243160002217 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 243160002218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243160002219 DNA binding residues [nucleotide binding] 243160002220 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 243160002221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 243160002222 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243160002223 Leucine carboxyl methyltransferase; Region: LCM; cl01306 243160002224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160002225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160002226 DNA-binding site [nucleotide binding]; DNA binding site 243160002227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160002228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160002229 homodimer interface [polypeptide binding]; other site 243160002230 catalytic residue [active] 243160002231 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 243160002232 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 243160002233 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243160002234 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 243160002235 active site 243160002236 catalytic site [active] 243160002237 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 243160002238 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 243160002239 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243160002240 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243160002241 catalytic site [active] 243160002242 active site 243160002243 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 243160002244 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243160002245 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243160002246 active site 243160002247 catalytic site [active] 243160002248 trehalose synthase; Region: treS_nterm; TIGR02456 243160002249 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 243160002250 active site 243160002251 catalytic site [active] 243160002252 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 243160002253 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 243160002254 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 243160002255 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243160002256 Interdomain contacts; other site 243160002257 Cytokine receptor motif; other site 243160002258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160002259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160002261 dimerization interface [polypeptide binding]; other site 243160002262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160002263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002264 active site 243160002265 phosphorylation site [posttranslational modification] 243160002266 intermolecular recognition site; other site 243160002267 dimerization interface [polypeptide binding]; other site 243160002268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160002269 DNA binding site [nucleotide binding] 243160002270 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 243160002271 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 243160002272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160002273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002274 active site 243160002275 phosphorylation site [posttranslational modification] 243160002276 intermolecular recognition site; other site 243160002277 dimerization interface [polypeptide binding]; other site 243160002278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160002279 DNA binding site [nucleotide binding] 243160002280 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 243160002281 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160002282 trimer interface [polypeptide binding]; other site 243160002283 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 243160002284 trimer interface [polypeptide binding]; other site 243160002285 YadA-like C-terminal region; Region: YadA; pfam03895 243160002286 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160002287 ligand binding site [chemical binding]; other site 243160002288 TPR repeat; Region: TPR_11; pfam13414 243160002289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160002290 binding surface 243160002291 TPR motif; other site 243160002292 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 243160002293 H-NS histone family; Region: Histone_HNS; pfam00816 243160002294 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160002295 Ricin-type beta-trefoil; Region: RICIN; smart00458 243160002296 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 243160002297 putative sugar binding sites [chemical binding]; other site 243160002298 Q-X-W motif; other site 243160002299 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 243160002300 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 243160002301 Galactose oxidase, central domain; Region: Kelch_3; cl02701 243160002302 Kelch motif; Region: Kelch_6; pfam13964 243160002303 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 243160002304 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 243160002305 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 243160002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 243160002307 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160002308 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160002309 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 243160002310 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 243160002311 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 243160002312 HTH-like domain; Region: HTH_21; pfam13276 243160002313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002314 Integrase core domain; Region: rve; pfam00665 243160002315 Integrase core domain; Region: rve_3; pfam13683 243160002316 Transposase; Region: HTH_Tnp_1; pfam01527 243160002317 manganese transport protein MntH; Reviewed; Region: PRK00701 243160002318 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243160002319 H-NS histone family; Region: Histone_HNS; pfam00816 243160002320 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160002321 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 243160002322 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160002323 active site 243160002324 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 243160002325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002326 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243160002327 dimerization interface [polypeptide binding]; other site 243160002328 substrate binding pocket [chemical binding]; other site 243160002329 Spore Coat Protein U domain; Region: SCPU; pfam05229 243160002330 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 243160002331 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 243160002332 Spore Coat Protein U domain; Region: SCPU; pfam05229 243160002333 Spore Coat Protein U domain; Region: SCPU; pfam05229 243160002334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160002335 dimer interface [polypeptide binding]; other site 243160002336 phosphorylation site [posttranslational modification] 243160002337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160002338 ATP binding site [chemical binding]; other site 243160002339 Mg2+ binding site [ion binding]; other site 243160002340 G-X-G motif; other site 243160002341 Response regulator receiver domain; Region: Response_reg; pfam00072 243160002342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002343 active site 243160002344 phosphorylation site [posttranslational modification] 243160002345 intermolecular recognition site; other site 243160002346 dimerization interface [polypeptide binding]; other site 243160002347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002349 active site 243160002350 phosphorylation site [posttranslational modification] 243160002351 intermolecular recognition site; other site 243160002352 dimerization interface [polypeptide binding]; other site 243160002353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160002354 DNA binding residues [nucleotide binding] 243160002355 dimerization interface [polypeptide binding]; other site 243160002356 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002358 putative substrate translocation pore; other site 243160002359 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243160002360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160002361 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160002362 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 243160002363 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 243160002364 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 243160002365 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 243160002366 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 243160002367 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 243160002368 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243160002369 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 243160002370 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 243160002371 nudix motif; other site 243160002372 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 243160002373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160002374 active site 243160002375 HIGH motif; other site 243160002376 nucleotide binding site [chemical binding]; other site 243160002377 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 243160002378 KMSKS motif; other site 243160002379 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 243160002380 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243160002381 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243160002382 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243160002383 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243160002384 motif 1; other site 243160002385 active site 243160002386 motif 2; other site 243160002387 motif 3; other site 243160002388 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243160002389 DHHA1 domain; Region: DHHA1; pfam02272 243160002390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160002391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160002393 dimerization interface [polypeptide binding]; other site 243160002394 Transposase; Region: HTH_Tnp_1; pfam01527 243160002395 HTH-like domain; Region: HTH_21; pfam13276 243160002396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002397 Integrase core domain; Region: rve; pfam00665 243160002398 Integrase core domain; Region: rve_3; pfam13683 243160002399 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243160002400 nudix motif; other site 243160002401 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243160002402 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 243160002403 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 243160002404 putative active site [active] 243160002405 metal binding site [ion binding]; metal-binding site 243160002406 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243160002407 active site 243160002408 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243160002409 TM-ABC transporter signature motif; other site 243160002410 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 243160002411 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243160002412 TM-ABC transporter signature motif; other site 243160002413 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243160002414 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243160002415 Walker A/P-loop; other site 243160002416 ATP binding site [chemical binding]; other site 243160002417 Q-loop/lid; other site 243160002418 ABC transporter signature motif; other site 243160002419 Walker B; other site 243160002420 D-loop; other site 243160002421 H-loop/switch region; other site 243160002422 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243160002423 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243160002424 Walker A/P-loop; other site 243160002425 ATP binding site [chemical binding]; other site 243160002426 Q-loop/lid; other site 243160002427 ABC transporter signature motif; other site 243160002428 Walker B; other site 243160002429 D-loop; other site 243160002430 H-loop/switch region; other site 243160002431 KduI/IolB family; Region: KduI; pfam04962 243160002432 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243160002433 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 243160002434 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160002435 PYR/PP interface [polypeptide binding]; other site 243160002436 dimer interface [polypeptide binding]; other site 243160002437 TPP binding site [chemical binding]; other site 243160002438 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160002439 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 243160002440 TPP-binding site; other site 243160002441 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160002442 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 243160002443 substrate binding site [chemical binding]; other site 243160002444 ATP binding site [chemical binding]; other site 243160002445 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 243160002446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 243160002447 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243160002448 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243160002449 Walker A/P-loop; other site 243160002450 ATP binding site [chemical binding]; other site 243160002451 Q-loop/lid; other site 243160002452 ABC transporter signature motif; other site 243160002453 Walker B; other site 243160002454 D-loop; other site 243160002455 H-loop/switch region; other site 243160002456 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160002457 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160002458 TM-ABC transporter signature motif; other site 243160002459 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 243160002460 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243160002461 putative ligand binding site [chemical binding]; other site 243160002462 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160002463 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160002464 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160002465 putative active site [active] 243160002466 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243160002467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243160002468 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243160002469 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243160002470 CPxP motif; other site 243160002471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160002472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002473 active site 243160002474 phosphorylation site [posttranslational modification] 243160002475 intermolecular recognition site; other site 243160002476 dimerization interface [polypeptide binding]; other site 243160002477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160002478 DNA binding site [nucleotide binding] 243160002479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 243160002480 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243160002481 FecR protein; Region: FecR; pfam04773 243160002482 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 243160002483 CHASE2 domain; Region: CHASE2; pfam05226 243160002484 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243160002485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160002486 dimer interface [polypeptide binding]; other site 243160002487 phosphorylation site [posttranslational modification] 243160002488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160002489 ATP binding site [chemical binding]; other site 243160002490 Mg2+ binding site [ion binding]; other site 243160002491 G-X-G motif; other site 243160002492 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 243160002493 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243160002494 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 243160002495 active site 243160002496 tetramer interface; other site 243160002497 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243160002498 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243160002499 HIGH motif; other site 243160002500 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243160002501 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243160002502 active site 243160002503 KMSKS motif; other site 243160002504 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243160002505 tRNA binding surface [nucleotide binding]; other site 243160002506 anticodon binding site; other site 243160002507 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243160002508 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 243160002509 Part of AAA domain; Region: AAA_19; pfam13245 243160002510 Family description; Region: UvrD_C_2; pfam13538 243160002511 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 243160002512 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 243160002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160002515 putative substrate translocation pore; other site 243160002516 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160002517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160002518 dimer interface [polypeptide binding]; other site 243160002519 putative CheW interface [polypeptide binding]; other site 243160002520 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 243160002521 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160002522 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160002523 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 243160002524 Fusaric acid resistance protein family; Region: FUSC; pfam04632 243160002525 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 243160002526 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160002527 transcriptional regulator; Provisional; Region: PRK10632 243160002528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002529 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160002530 putative effector binding pocket; other site 243160002531 dimerization interface [polypeptide binding]; other site 243160002532 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160002533 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160002534 active site 243160002535 metal binding site [ion binding]; metal-binding site 243160002536 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160002537 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160002538 FAD binding domain; Region: FAD_binding_4; pfam01565 243160002539 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 243160002540 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243160002541 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160002542 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 243160002543 Protein of unknown function (DUF962); Region: DUF962; cl01879 243160002544 FOG: CBS domain [General function prediction only]; Region: COG0517 243160002545 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243160002546 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 243160002547 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 243160002548 Tetramer interface [polypeptide binding]; other site 243160002549 active site 243160002550 FMN-binding site [chemical binding]; other site 243160002551 HTH-like domain; Region: HTH_21; pfam13276 243160002552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002553 Integrase core domain; Region: rve; pfam00665 243160002554 Integrase core domain; Region: rve_3; pfam13683 243160002555 Transposase; Region: HTH_Tnp_1; pfam01527 243160002556 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 243160002557 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243160002558 DNA binding residues [nucleotide binding] 243160002559 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160002560 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243160002561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243160002562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160002563 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160002564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160002565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160002566 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 243160002567 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243160002568 Cl- selectivity filter; other site 243160002569 Cl- binding residues [ion binding]; other site 243160002570 pore gating glutamate residue; other site 243160002571 dimer interface [polypeptide binding]; other site 243160002572 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 243160002573 Predicted membrane protein [Function unknown]; Region: COG2855 243160002574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160002575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160002577 dimerization interface [polypeptide binding]; other site 243160002578 SdpI/YhfL protein family; Region: SdpI; pfam13630 243160002579 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160002580 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 243160002581 substrate binding site [chemical binding]; other site 243160002582 ATP binding site [chemical binding]; other site 243160002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002584 D-galactonate transporter; Region: 2A0114; TIGR00893 243160002585 putative substrate translocation pore; other site 243160002586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243160002587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243160002588 DNA binding site [nucleotide binding] 243160002589 domain linker motif; other site 243160002590 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 243160002591 putative ligand binding site [chemical binding]; other site 243160002592 putative dimerization interface [polypeptide binding]; other site 243160002593 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 243160002594 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 243160002595 PGDYG protein; Region: PGDYG; pfam14083 243160002596 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 243160002597 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 243160002598 AsnC family; Region: AsnC_trans_reg; pfam01037 243160002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002600 Double zinc ribbon; Region: DZR; pfam12773 243160002601 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 243160002602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160002603 AAA domain; Region: AAA_33; pfam13671 243160002604 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 243160002605 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 243160002606 oligomer interface [polypeptide binding]; other site 243160002607 metal binding site [ion binding]; metal-binding site 243160002608 metal binding site [ion binding]; metal-binding site 243160002609 putative Cl binding site [ion binding]; other site 243160002610 basic sphincter; other site 243160002611 hydrophobic gate; other site 243160002612 periplasmic entrance; other site 243160002613 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 243160002614 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 243160002615 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243160002616 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 243160002617 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 243160002618 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243160002619 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243160002620 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243160002621 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 243160002622 NosL; Region: NosL; pfam05573 243160002623 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243160002624 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243160002625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160002626 Walker A/P-loop; other site 243160002627 ATP binding site [chemical binding]; other site 243160002628 Q-loop/lid; other site 243160002629 ABC transporter signature motif; other site 243160002630 Walker B; other site 243160002631 D-loop; other site 243160002632 H-loop/switch region; other site 243160002633 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 243160002634 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 243160002635 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 243160002636 nitrous-oxide reductase; Validated; Region: PRK02888 243160002637 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243160002638 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 243160002639 ApbE family; Region: ApbE; pfam02424 243160002640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243160002641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160002642 Walker A/P-loop; other site 243160002643 ATP binding site [chemical binding]; other site 243160002644 Q-loop/lid; other site 243160002645 ABC transporter signature motif; other site 243160002646 Walker B; other site 243160002647 D-loop; other site 243160002648 H-loop/switch region; other site 243160002649 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243160002650 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160002651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160002652 dimerization interface [polypeptide binding]; other site 243160002653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160002654 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160002655 dimer interface [polypeptide binding]; other site 243160002656 putative CheW interface [polypeptide binding]; other site 243160002657 dihydroxyacetone kinase; Provisional; Region: PRK14479 243160002658 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 243160002659 DAK2 domain; Region: Dak2; pfam02734 243160002660 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243160002661 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243160002662 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243160002663 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243160002664 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 243160002665 MEKHLA domain; Region: MEKHLA; pfam08670 243160002666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160002667 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160002668 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 243160002669 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 243160002670 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 243160002671 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 243160002672 PapC N-terminal domain; Region: PapC_N; pfam13954 243160002673 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 243160002674 PapC C-terminal domain; Region: PapC_C; pfam13953 243160002675 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 243160002676 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 243160002677 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160002678 Haemagglutinin; Region: HIM; pfam05662 243160002679 YadA-like C-terminal region; Region: YadA; pfam03895 243160002680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160002682 active site 243160002683 phosphorylation site [posttranslational modification] 243160002684 intermolecular recognition site; other site 243160002685 dimerization interface [polypeptide binding]; other site 243160002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160002687 DNA binding residues [nucleotide binding] 243160002688 dimerization interface [polypeptide binding]; other site 243160002689 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 243160002690 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 243160002691 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 243160002692 active site 243160002693 Transposase; Region: HTH_Tnp_1; pfam01527 243160002694 HTH-like domain; Region: HTH_21; pfam13276 243160002695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002696 Integrase core domain; Region: rve; pfam00665 243160002697 Integrase core domain; Region: rve_3; pfam13683 243160002698 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 243160002699 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 243160002700 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 243160002701 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 243160002702 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243160002703 Predicted ATPase [General function prediction only]; Region: COG1485 243160002704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160002705 Walker B; other site 243160002706 D-loop; other site 243160002707 H-loop/switch region; other site 243160002708 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 243160002709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160002710 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243160002711 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 243160002712 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160002713 E3 interaction surface; other site 243160002714 lipoyl attachment site [posttranslational modification]; other site 243160002715 e3 binding domain; Region: E3_binding; pfam02817 243160002716 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243160002717 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 243160002718 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 243160002719 TPP-binding site [chemical binding]; other site 243160002720 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 243160002721 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243160002722 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243160002723 G1 box; other site 243160002724 putative GEF interaction site [polypeptide binding]; other site 243160002725 GTP/Mg2+ binding site [chemical binding]; other site 243160002726 Switch I region; other site 243160002727 G2 box; other site 243160002728 G3 box; other site 243160002729 Switch II region; other site 243160002730 G4 box; other site 243160002731 G5 box; other site 243160002732 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243160002733 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243160002734 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243160002735 MarR family; Region: MarR_2; pfam12802 243160002736 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160002737 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 243160002738 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160002739 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160002740 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160002741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002742 putative substrate translocation pore; other site 243160002743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002744 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 243160002745 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243160002746 RNA binding site [nucleotide binding]; other site 243160002747 active site 243160002748 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 243160002749 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 243160002750 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 243160002751 translation initiation factor IF-2; Region: IF-2; TIGR00487 243160002752 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243160002753 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243160002754 G1 box; other site 243160002755 putative GEF interaction site [polypeptide binding]; other site 243160002756 GTP/Mg2+ binding site [chemical binding]; other site 243160002757 Switch I region; other site 243160002758 G2 box; other site 243160002759 G3 box; other site 243160002760 Switch II region; other site 243160002761 G4 box; other site 243160002762 G5 box; other site 243160002763 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243160002764 Translation-initiation factor 2; Region: IF-2; pfam11987 243160002765 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243160002766 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 243160002767 NusA N-terminal domain; Region: NusA_N; pfam08529 243160002768 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243160002769 RNA binding site [nucleotide binding]; other site 243160002770 homodimer interface [polypeptide binding]; other site 243160002771 NusA-like KH domain; Region: KH_5; pfam13184 243160002772 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243160002773 G-X-X-G motif; other site 243160002774 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243160002775 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243160002776 ribosome maturation protein RimP; Reviewed; Region: PRK00092 243160002777 Sm and related proteins; Region: Sm_like; cl00259 243160002778 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 243160002779 putative oligomer interface [polypeptide binding]; other site 243160002780 putative RNA binding site [nucleotide binding]; other site 243160002781 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243160002782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160002783 RNA binding surface [nucleotide binding]; other site 243160002784 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 243160002785 probable active site [active] 243160002786 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243160002787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160002788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002789 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 243160002790 putative dimerization interface [polypeptide binding]; other site 243160002791 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243160002792 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 243160002793 Uncharacterized conserved protein [Function unknown]; Region: COG1434 243160002794 putative active site [active] 243160002795 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 243160002796 HTH-like domain; Region: HTH_21; pfam13276 243160002797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002798 Integrase core domain; Region: rve; pfam00665 243160002799 Integrase core domain; Region: rve_3; pfam13683 243160002800 Transposase; Region: HTH_Tnp_1; pfam01527 243160002801 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 243160002802 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 243160002803 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 243160002804 Transposase; Region: HTH_Tnp_1; pfam01527 243160002805 HTH-like domain; Region: HTH_21; pfam13276 243160002806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002807 Integrase core domain; Region: rve; pfam00665 243160002808 Integrase core domain; Region: rve_3; pfam13683 243160002809 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 243160002810 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 243160002811 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243160002812 DNA binding residues [nucleotide binding] 243160002813 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243160002814 IHF dimer interface [polypeptide binding]; other site 243160002815 IHF - DNA interface [nucleotide binding]; other site 243160002816 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 243160002817 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243160002818 putative tRNA-binding site [nucleotide binding]; other site 243160002819 B3/4 domain; Region: B3_4; pfam03483 243160002820 tRNA synthetase B5 domain; Region: B5; smart00874 243160002821 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243160002822 dimer interface [polypeptide binding]; other site 243160002823 motif 1; other site 243160002824 motif 3; other site 243160002825 motif 2; other site 243160002826 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 243160002827 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243160002828 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243160002829 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243160002830 dimer interface [polypeptide binding]; other site 243160002831 motif 1; other site 243160002832 active site 243160002833 motif 2; other site 243160002834 motif 3; other site 243160002835 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243160002836 23S rRNA binding site [nucleotide binding]; other site 243160002837 L21 binding site [polypeptide binding]; other site 243160002838 L13 binding site [polypeptide binding]; other site 243160002839 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243160002840 translation initiation factor IF-3; Region: infC; TIGR00168 243160002841 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243160002842 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243160002843 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 243160002844 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 243160002845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243160002846 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243160002847 active site 243160002848 dimer interface [polypeptide binding]; other site 243160002849 motif 1; other site 243160002850 motif 2; other site 243160002851 motif 3; other site 243160002852 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243160002853 anticodon binding site; other site 243160002854 HD domain; Region: HD_4; pfam13328 243160002855 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 243160002856 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243160002857 synthetase active site [active] 243160002858 NTP binding site [chemical binding]; other site 243160002859 metal binding site [ion binding]; metal-binding site 243160002860 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243160002861 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243160002862 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 243160002863 homotrimer interaction site [polypeptide binding]; other site 243160002864 putative active site [active] 243160002865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160002866 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160002867 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243160002868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002869 transcriptional activator TtdR; Provisional; Region: PRK09801 243160002870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160002871 putative effector binding pocket; other site 243160002872 dimerization interface [polypeptide binding]; other site 243160002873 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 243160002874 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 243160002875 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 243160002876 short chain dehydrogenase; Provisional; Region: PRK07041 243160002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160002878 NAD(P) binding site [chemical binding]; other site 243160002879 active site 243160002880 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 243160002881 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 243160002882 PAS domain; Region: PAS_9; pfam13426 243160002883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160002884 putative active site [active] 243160002885 heme pocket [chemical binding]; other site 243160002886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160002887 DNA binding residues [nucleotide binding] 243160002888 dimerization interface [polypeptide binding]; other site 243160002889 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 243160002890 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243160002891 active site 243160002892 short chain dehydrogenase; Provisional; Region: PRK06949 243160002893 classical (c) SDRs; Region: SDR_c; cd05233 243160002894 NAD(P) binding site [chemical binding]; other site 243160002895 active site 243160002896 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 243160002897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243160002898 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 243160002899 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 243160002900 Transposase; Region: HTH_Tnp_1; pfam01527 243160002901 HTH-like domain; Region: HTH_21; pfam13276 243160002902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160002903 Integrase core domain; Region: rve; pfam00665 243160002904 Integrase core domain; Region: rve_3; pfam13683 243160002905 Cupin-like domain; Region: Cupin_8; pfam13621 243160002906 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243160002907 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160002908 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160002909 trimer interface [polypeptide binding]; other site 243160002910 eyelet of channel; other site 243160002911 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160002912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160002913 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160002914 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160002915 EamA-like transporter family; Region: EamA; pfam00892 243160002916 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 243160002917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160002918 dimer interface [polypeptide binding]; other site 243160002919 putative CheW interface [polypeptide binding]; other site 243160002920 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 243160002921 AMP-binding domain protein; Validated; Region: PRK07529 243160002922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160002923 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 243160002924 acyl-activating enzyme (AAE) consensus motif; other site 243160002925 putative AMP binding site [chemical binding]; other site 243160002926 putative active site [active] 243160002927 putative CoA binding site [chemical binding]; other site 243160002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160002929 putative substrate translocation pore; other site 243160002930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160002931 S-adenosylmethionine binding site [chemical binding]; other site 243160002932 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 243160002933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002934 dimer interface [polypeptide binding]; other site 243160002935 conserved gate region; other site 243160002936 putative PBP binding loops; other site 243160002937 ABC-ATPase subunit interface; other site 243160002938 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 243160002939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160002940 Walker A/P-loop; other site 243160002941 ATP binding site [chemical binding]; other site 243160002942 Q-loop/lid; other site 243160002943 ABC transporter signature motif; other site 243160002944 Walker B; other site 243160002945 D-loop; other site 243160002946 H-loop/switch region; other site 243160002947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160002948 ABC-ATPase subunit interface; other site 243160002949 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 243160002950 arginine deiminase; Provisional; Region: PRK01388 243160002951 ornithine carbamoyltransferase; Validated; Region: PRK02102 243160002952 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243160002953 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243160002954 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 243160002955 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 243160002956 putative substrate binding site [chemical binding]; other site 243160002957 nucleotide binding site [chemical binding]; other site 243160002958 nucleotide binding site [chemical binding]; other site 243160002959 homodimer interface [polypeptide binding]; other site 243160002960 short chain dehydrogenase; Provisional; Region: PRK09291 243160002961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160002962 NAD(P) binding site [chemical binding]; other site 243160002963 active site 243160002964 Domain of unknown function (DUF336); Region: DUF336; pfam03928 243160002965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160002966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160002967 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 243160002968 putative effector binding pocket; other site 243160002969 putative dimerization interface [polypeptide binding]; other site 243160002970 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 243160002971 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 243160002972 C-terminal domain interface [polypeptide binding]; other site 243160002973 GSH binding site (G-site) [chemical binding]; other site 243160002974 dimer interface [polypeptide binding]; other site 243160002975 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 243160002976 dimer interface [polypeptide binding]; other site 243160002977 N-terminal domain interface [polypeptide binding]; other site 243160002978 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243160002979 MarR family; Region: MarR_2; pfam12802 243160002980 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160002981 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 243160002982 dimerization interface [polypeptide binding]; other site 243160002983 ligand binding site [chemical binding]; other site 243160002984 MarR family; Region: MarR_2; cl17246 243160002985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160002986 putative cyanate transporter; Provisional; Region: cynX; PRK09705 243160002987 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 243160002988 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 243160002989 active site 243160002990 SAM binding site [chemical binding]; other site 243160002991 homodimer interface [polypeptide binding]; other site 243160002992 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 243160002993 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 243160002994 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 243160002995 active site 243160002996 putative homodimer interface [polypeptide binding]; other site 243160002997 SAM binding site [chemical binding]; other site 243160002998 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 243160002999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160003000 S-adenosylmethionine binding site [chemical binding]; other site 243160003001 precorrin-3B synthase; Region: CobG; TIGR02435 243160003002 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160003003 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160003004 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 243160003005 Precorrin-8X methylmutase; Region: CbiC; pfam02570 243160003006 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 243160003007 active site 243160003008 SAM binding site [chemical binding]; other site 243160003009 homodimer interface [polypeptide binding]; other site 243160003010 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 243160003011 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 243160003012 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 243160003013 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 243160003014 active site 243160003015 SAM binding site [chemical binding]; other site 243160003016 homodimer interface [polypeptide binding]; other site 243160003017 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 243160003018 active site 243160003019 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 243160003020 aromatic chitin/cellulose binding site residues [chemical binding]; other site 243160003021 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 243160003022 aromatic chitin/cellulose binding site residues [chemical binding]; other site 243160003023 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 243160003024 Serine hydrolase (FSH1); Region: FSH1; pfam03959 243160003025 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 243160003026 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 243160003027 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 243160003028 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 243160003029 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 243160003030 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 243160003031 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 243160003032 High-affinity nickel-transport protein; Region: NicO; cl00964 243160003033 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 243160003034 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 243160003035 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 243160003036 homodimer interface [polypeptide binding]; other site 243160003037 Walker A motif; other site 243160003038 ATP binding site [chemical binding]; other site 243160003039 hydroxycobalamin binding site [chemical binding]; other site 243160003040 Walker B motif; other site 243160003041 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 243160003042 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 243160003043 catalytic triad [active] 243160003044 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 243160003045 catalytic site [active] 243160003046 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 243160003047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160003048 N-terminal plug; other site 243160003049 ligand-binding site [chemical binding]; other site 243160003050 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 243160003051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160003052 Condensation domain; Region: Condensation; pfam00668 243160003053 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243160003054 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160003055 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160003056 acyl-activating enzyme (AAE) consensus motif; other site 243160003057 AMP binding site [chemical binding]; other site 243160003058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160003059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243160003060 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 243160003061 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 243160003062 Walker A/P-loop; other site 243160003063 ATP binding site [chemical binding]; other site 243160003064 Q-loop/lid; other site 243160003065 ABC transporter signature motif; other site 243160003066 Walker B; other site 243160003067 D-loop; other site 243160003068 H-loop/switch region; other site 243160003069 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 243160003070 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 243160003071 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243160003072 siderophore binding site; other site 243160003073 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 243160003074 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 243160003075 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 243160003076 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 243160003077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 243160003078 dimer interface [polypeptide binding]; other site 243160003079 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243160003080 ABC-ATPase subunit interface; other site 243160003081 dimer interface [polypeptide binding]; other site 243160003082 putative PBP binding regions; other site 243160003083 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 243160003084 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 243160003085 Walker A/P-loop; other site 243160003086 ATP binding site [chemical binding]; other site 243160003087 Q-loop/lid; other site 243160003088 ABC transporter signature motif; other site 243160003089 Walker B; other site 243160003090 D-loop; other site 243160003091 H-loop/switch region; other site 243160003092 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 243160003093 MbtH-like protein; Region: MbtH; cl01279 243160003094 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 243160003095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160003096 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243160003097 DNA binding residues [nucleotide binding] 243160003098 short chain dehydrogenase; Provisional; Region: PRK07060 243160003099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160003100 NAD(P) binding site [chemical binding]; other site 243160003101 active site 243160003102 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 243160003103 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 243160003104 N- and C-terminal domain interface [polypeptide binding]; other site 243160003105 putative active site [active] 243160003106 MgATP binding site [chemical binding]; other site 243160003107 catalytic site [active] 243160003108 metal binding site [ion binding]; metal-binding site 243160003109 putative xylulose binding site [chemical binding]; other site 243160003110 putative homodimer interface [polypeptide binding]; other site 243160003111 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243160003112 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243160003113 NAD(P) binding site [chemical binding]; other site 243160003114 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 243160003115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160003116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160003117 TM-ABC transporter signature motif; other site 243160003118 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243160003119 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243160003120 Walker A/P-loop; other site 243160003121 ATP binding site [chemical binding]; other site 243160003122 Q-loop/lid; other site 243160003123 ABC transporter signature motif; other site 243160003124 Walker B; other site 243160003125 D-loop; other site 243160003126 H-loop/switch region; other site 243160003127 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243160003128 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 243160003129 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243160003130 putative ligand binding site [chemical binding]; other site 243160003131 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160003132 Helix-turn-helix domain; Region: HTH_18; pfam12833 243160003133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160003134 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 243160003135 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 243160003136 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243160003137 Ligand Binding Site [chemical binding]; other site 243160003138 Molecular Tunnel; other site 243160003139 HTH-like domain; Region: HTH_21; pfam13276 243160003140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003141 Integrase core domain; Region: rve; pfam00665 243160003142 Integrase core domain; Region: rve_3; pfam13683 243160003143 Transposase; Region: HTH_Tnp_1; pfam01527 243160003144 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 243160003145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160003146 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 243160003147 substrate binding site [chemical binding]; other site 243160003148 dimerization interface [polypeptide binding]; other site 243160003149 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 243160003150 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 243160003151 Walker A/P-loop; other site 243160003152 ATP binding site [chemical binding]; other site 243160003153 Q-loop/lid; other site 243160003154 ABC transporter signature motif; other site 243160003155 Walker B; other site 243160003156 D-loop; other site 243160003157 H-loop/switch region; other site 243160003158 TOBE-like domain; Region: TOBE_3; pfam12857 243160003159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243160003160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160003161 dimer interface [polypeptide binding]; other site 243160003162 conserved gate region; other site 243160003163 putative PBP binding loops; other site 243160003164 ABC-ATPase subunit interface; other site 243160003165 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243160003166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160003167 substrate binding pocket [chemical binding]; other site 243160003168 membrane-bound complex binding site; other site 243160003169 LexA repressor; Validated; Region: PRK00215 243160003170 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243160003171 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243160003172 Catalytic site [active] 243160003173 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 243160003174 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160003175 Ligand Binding Site [chemical binding]; other site 243160003176 HTH-like domain; Region: HTH_21; pfam13276 243160003177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003178 Integrase core domain; Region: rve; pfam00665 243160003179 Integrase core domain; Region: rve_3; pfam13683 243160003180 Transposase; Region: HTH_Tnp_1; pfam01527 243160003181 nodulation ABC transporter NodI; Provisional; Region: PRK13537 243160003182 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 243160003183 Walker A/P-loop; other site 243160003184 ATP binding site [chemical binding]; other site 243160003185 Q-loop/lid; other site 243160003186 ABC transporter signature motif; other site 243160003187 Walker B; other site 243160003188 D-loop; other site 243160003189 H-loop/switch region; other site 243160003190 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243160003191 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160003192 Predicted permease; Region: DUF318; cl17795 243160003193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243160003194 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243160003195 active site 243160003196 catalytic tetrad [active] 243160003197 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160003198 CoenzymeA binding site [chemical binding]; other site 243160003199 subunit interaction site [polypeptide binding]; other site 243160003200 PHB binding site; other site 243160003201 Predicted transcriptional regulators [Transcription]; Region: COG1733 243160003202 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243160003203 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 243160003204 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 243160003205 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 243160003206 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243160003207 FMN binding site [chemical binding]; other site 243160003208 active site 243160003209 catalytic residues [active] 243160003210 substrate binding site [chemical binding]; other site 243160003211 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 243160003212 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160003213 Transposase; Region: HTH_Tnp_1; pfam01527 243160003214 HTH-like domain; Region: HTH_21; pfam13276 243160003215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003216 Integrase core domain; Region: rve; pfam00665 243160003217 Integrase core domain; Region: rve_3; pfam13683 243160003218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160003219 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160003220 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 243160003221 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243160003222 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243160003223 Walker A/P-loop; other site 243160003224 ATP binding site [chemical binding]; other site 243160003225 Q-loop/lid; other site 243160003226 ABC transporter signature motif; other site 243160003227 Walker B; other site 243160003228 D-loop; other site 243160003229 H-loop/switch region; other site 243160003230 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243160003231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160003232 dimer interface [polypeptide binding]; other site 243160003233 conserved gate region; other site 243160003234 putative PBP binding loops; other site 243160003235 ABC-ATPase subunit interface; other site 243160003236 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 243160003237 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 243160003238 active site 243160003239 dimer interface [polypeptide binding]; other site 243160003240 non-prolyl cis peptide bond; other site 243160003241 insertion regions; other site 243160003242 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 243160003243 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160003244 substrate binding site [chemical binding]; other site 243160003245 oxyanion hole (OAH) forming residues; other site 243160003246 trimer interface [polypeptide binding]; other site 243160003247 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 243160003248 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243160003249 hypothetical protein; Provisional; Region: PRK02487 243160003250 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 243160003251 nudix motif; other site 243160003252 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 243160003253 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 243160003254 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 243160003255 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 243160003256 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 243160003257 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 243160003258 quinone interaction residues [chemical binding]; other site 243160003259 active site 243160003260 catalytic residues [active] 243160003261 FMN binding site [chemical binding]; other site 243160003262 substrate binding site [chemical binding]; other site 243160003263 cystine transporter subunit; Provisional; Region: PRK11260 243160003264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160003265 substrate binding pocket [chemical binding]; other site 243160003266 membrane-bound complex binding site; other site 243160003267 hinge residues; other site 243160003268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160003269 dimer interface [polypeptide binding]; other site 243160003270 conserved gate region; other site 243160003271 putative PBP binding loops; other site 243160003272 ABC-ATPase subunit interface; other site 243160003273 Transposase; Region: HTH_Tnp_1; pfam01527 243160003274 HTH-like domain; Region: HTH_21; pfam13276 243160003275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003276 Integrase core domain; Region: rve; pfam00665 243160003277 Integrase core domain; Region: rve_3; pfam13683 243160003278 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243160003279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243160003280 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243160003281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160003282 DNA-binding site [nucleotide binding]; DNA binding site 243160003283 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243160003284 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 243160003285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243160003286 active site 243160003287 dimer interface [polypeptide binding]; other site 243160003288 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243160003289 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243160003290 amidase catalytic site [active] 243160003291 Zn binding residues [ion binding]; other site 243160003292 substrate binding site [chemical binding]; other site 243160003293 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243160003294 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 243160003295 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 243160003296 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243160003297 ribonuclease R; Region: RNase_R; TIGR02063 243160003298 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 243160003299 RNB domain; Region: RNB; pfam00773 243160003300 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160003301 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 243160003302 RNA binding site [nucleotide binding]; other site 243160003303 Transposase domain (DUF772); Region: DUF772; pfam05598 243160003304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160003305 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160003306 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160003307 dimer interface [polypeptide binding]; other site 243160003308 putative CheW interface [polypeptide binding]; other site 243160003309 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243160003310 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243160003311 metal binding site [ion binding]; metal-binding site 243160003312 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243160003313 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243160003314 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 243160003315 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 243160003316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243160003317 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243160003318 putative sialic acid transporter; Region: 2A0112; TIGR00891 243160003319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160003320 putative substrate translocation pore; other site 243160003321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160003322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160003323 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 243160003324 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 243160003325 acyl-activating enzyme (AAE) consensus motif; other site 243160003326 putative AMP binding site [chemical binding]; other site 243160003327 putative active site [active] 243160003328 putative CoA binding site [chemical binding]; other site 243160003329 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 243160003330 bacterial Hfq-like; Region: Hfq; cd01716 243160003331 hexamer interface [polypeptide binding]; other site 243160003332 Sm1 motif; other site 243160003333 RNA binding site [nucleotide binding]; other site 243160003334 Sm2 motif; other site 243160003335 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 243160003336 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 243160003337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003338 Walker A motif; other site 243160003339 ATP binding site [chemical binding]; other site 243160003340 Walker B motif; other site 243160003341 arginine finger; other site 243160003342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160003343 Predicted membrane protein [Function unknown]; Region: COG4655 243160003344 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 243160003345 TPR repeat; Region: TPR_11; pfam13414 243160003346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160003347 binding surface 243160003348 TPR motif; other site 243160003349 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 243160003350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160003351 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 243160003352 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 243160003353 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 243160003354 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 243160003355 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160003356 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 243160003357 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 243160003358 Transposase; Region: HTH_Tnp_1; pfam01527 243160003359 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 243160003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160003361 dimer interface [polypeptide binding]; other site 243160003362 conserved gate region; other site 243160003363 putative PBP binding loops; other site 243160003364 ABC-ATPase subunit interface; other site 243160003365 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 243160003366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160003367 Walker A/P-loop; other site 243160003368 ATP binding site [chemical binding]; other site 243160003369 Q-loop/lid; other site 243160003370 ABC transporter signature motif; other site 243160003371 Walker B; other site 243160003372 D-loop; other site 243160003373 H-loop/switch region; other site 243160003374 TOBE domain; Region: TOBE_2; pfam08402 243160003375 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 243160003376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243160003377 Predicted Fe-S protein [General function prediction only]; Region: COG3313 243160003378 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 243160003379 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 243160003380 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243160003381 FMN binding site [chemical binding]; other site 243160003382 substrate binding site [chemical binding]; other site 243160003383 putative catalytic residue [active] 243160003384 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 243160003385 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160003386 NAD binding site [chemical binding]; other site 243160003387 catalytic residues [active] 243160003388 Burkholderia Lethal Factor 1; Region: BPSL1549; cd12812 243160003389 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 243160003390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160003391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160003392 ABC transporter; Region: ABC_tran_2; pfam12848 243160003393 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160003394 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 243160003395 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243160003396 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 243160003397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160003398 Walker A/P-loop; other site 243160003399 ATP binding site [chemical binding]; other site 243160003400 Q-loop/lid; other site 243160003401 ABC transporter signature motif; other site 243160003402 Walker B; other site 243160003403 D-loop; other site 243160003404 H-loop/switch region; other site 243160003405 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 243160003406 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 243160003407 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243160003408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160003409 motif II; other site 243160003410 cystathionine beta-lyase; Provisional; Region: PRK07050 243160003411 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160003412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160003413 catalytic residue [active] 243160003414 beta-ketothiolase; Provisional; Region: PRK09051 243160003415 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160003416 dimer interface [polypeptide binding]; other site 243160003417 active site 243160003418 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160003419 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 243160003420 substrate binding site [chemical binding]; other site 243160003421 ATP binding site [chemical binding]; other site 243160003422 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 243160003423 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243160003424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160003425 FeS/SAM binding site; other site 243160003426 TRAM domain; Region: TRAM; cl01282 243160003427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 243160003428 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 243160003429 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 243160003430 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 243160003431 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243160003432 NAD(P) binding site [chemical binding]; other site 243160003433 homotetramer interface [polypeptide binding]; other site 243160003434 homodimer interface [polypeptide binding]; other site 243160003435 active site 243160003436 putative acyltransferase; Provisional; Region: PRK05790 243160003437 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160003438 dimer interface [polypeptide binding]; other site 243160003439 active site 243160003440 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 243160003441 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 243160003442 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 243160003443 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 243160003444 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243160003445 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160003446 RNA binding surface [nucleotide binding]; other site 243160003447 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243160003448 active site 243160003449 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243160003450 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243160003451 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 243160003452 DEAD_2; Region: DEAD_2; pfam06733 243160003453 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243160003454 Protein of unknown function (DUF465); Region: DUF465; pfam04325 243160003455 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 243160003456 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 243160003457 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 243160003458 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 243160003459 RNA binding site [nucleotide binding]; other site 243160003460 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 243160003461 potassium uptake protein; Region: kup; TIGR00794 243160003462 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 243160003463 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160003464 active site 243160003465 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 243160003466 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243160003467 GDP-binding site [chemical binding]; other site 243160003468 ACT binding site; other site 243160003469 IMP binding site; other site 243160003470 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 243160003471 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243160003472 dimer interface [polypeptide binding]; other site 243160003473 motif 1; other site 243160003474 active site 243160003475 motif 2; other site 243160003476 motif 3; other site 243160003477 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 243160003478 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 243160003479 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 243160003480 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 243160003481 HflK protein; Region: hflK; TIGR01933 243160003482 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 243160003483 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243160003484 HflX GTPase family; Region: HflX; cd01878 243160003485 G1 box; other site 243160003486 GTP/Mg2+ binding site [chemical binding]; other site 243160003487 Switch I region; other site 243160003488 G2 box; other site 243160003489 G3 box; other site 243160003490 Switch II region; other site 243160003491 G4 box; other site 243160003492 G5 box; other site 243160003493 bacterial Hfq-like; Region: Hfq; cd01716 243160003494 hexamer interface [polypeptide binding]; other site 243160003495 Sm1 motif; other site 243160003496 RNA binding site [nucleotide binding]; other site 243160003497 Sm2 motif; other site 243160003498 GTP-binding protein Der; Reviewed; Region: PRK00093 243160003499 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243160003500 G1 box; other site 243160003501 GTP/Mg2+ binding site [chemical binding]; other site 243160003502 Switch I region; other site 243160003503 G2 box; other site 243160003504 Switch II region; other site 243160003505 G3 box; other site 243160003506 G4 box; other site 243160003507 G5 box; other site 243160003508 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243160003509 G1 box; other site 243160003510 GTP/Mg2+ binding site [chemical binding]; other site 243160003511 Switch I region; other site 243160003512 G2 box; other site 243160003513 G3 box; other site 243160003514 Switch II region; other site 243160003515 G4 box; other site 243160003516 G5 box; other site 243160003517 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 243160003518 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243160003519 Trp docking motif [polypeptide binding]; other site 243160003520 active site 243160003521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 243160003522 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 243160003523 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 243160003524 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243160003525 dimer interface [polypeptide binding]; other site 243160003526 motif 1; other site 243160003527 active site 243160003528 motif 2; other site 243160003529 motif 3; other site 243160003530 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 243160003531 anticodon binding site; other site 243160003532 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 243160003533 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243160003534 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243160003535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160003536 non-specific DNA binding site [nucleotide binding]; other site 243160003537 salt bridge; other site 243160003538 sequence-specific DNA binding site [nucleotide binding]; other site 243160003539 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 243160003540 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 243160003541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160003542 FeS/SAM binding site; other site 243160003543 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243160003544 active site 243160003545 multimer interface [polypeptide binding]; other site 243160003546 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 243160003547 YccA-like proteins; Region: YccA_like; cd10433 243160003548 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 243160003549 TRAM domain; Region: TRAM; cl01282 243160003550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160003551 S-adenosylmethionine binding site [chemical binding]; other site 243160003552 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243160003553 putative catalytic site [active] 243160003554 putative metal binding site [ion binding]; other site 243160003555 putative phosphate binding site [ion binding]; other site 243160003556 putative catalytic site [active] 243160003557 putative phosphate binding site [ion binding]; other site 243160003558 putative metal binding site [ion binding]; other site 243160003559 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 243160003560 active site 243160003561 catalytic site [active] 243160003562 substrate binding site [chemical binding]; other site 243160003563 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 243160003564 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 243160003565 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243160003566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160003567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160003568 DNA binding residues [nucleotide binding] 243160003569 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243160003570 Peptidase family M23; Region: Peptidase_M23; pfam01551 243160003571 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 243160003572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160003573 S-adenosylmethionine binding site [chemical binding]; other site 243160003574 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243160003575 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243160003576 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243160003577 recombination protein RecR; Reviewed; Region: recR; PRK00076 243160003578 RecR protein; Region: RecR; pfam02132 243160003579 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243160003580 putative active site [active] 243160003581 putative metal-binding site [ion binding]; other site 243160003582 tetramer interface [polypeptide binding]; other site 243160003583 hypothetical protein; Validated; Region: PRK00153 243160003584 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 243160003585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003586 Walker A motif; other site 243160003587 ATP binding site [chemical binding]; other site 243160003588 Walker B motif; other site 243160003589 arginine finger; other site 243160003590 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243160003591 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243160003592 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160003593 catalytic residues [active] 243160003594 transcription termination factor Rho; Provisional; Region: rho; PRK09376 243160003595 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 243160003596 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 243160003597 RNA binding site [nucleotide binding]; other site 243160003598 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243160003599 multimer interface [polypeptide binding]; other site 243160003600 Walker A motif; other site 243160003601 ATP binding site [chemical binding]; other site 243160003602 Walker B motif; other site 243160003603 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243160003604 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243160003605 DNA binding residues [nucleotide binding] 243160003606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160003607 putative substrate translocation pore; other site 243160003608 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160003609 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 243160003610 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 243160003611 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243160003612 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 243160003613 putative efflux protein, MATE family; Region: matE; TIGR00797 243160003614 cation binding site [ion binding]; other site 243160003615 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243160003616 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243160003617 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 243160003618 DNA binding residues [nucleotide binding] 243160003619 putative dimer interface [polypeptide binding]; other site 243160003620 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 243160003621 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 243160003622 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243160003623 Clp amino terminal domain; Region: Clp_N; pfam02861 243160003624 Clp amino terminal domain; Region: Clp_N; pfam02861 243160003625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003626 Walker A motif; other site 243160003627 ATP binding site [chemical binding]; other site 243160003628 Walker B motif; other site 243160003629 arginine finger; other site 243160003630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003631 Walker A motif; other site 243160003632 ATP binding site [chemical binding]; other site 243160003633 Walker B motif; other site 243160003634 arginine finger; other site 243160003635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243160003636 Transcriptional regulator; Region: Rrf2; cl17282 243160003637 Rrf2 family protein; Region: rrf2_super; TIGR00738 243160003638 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 243160003639 MoaE homodimer interface [polypeptide binding]; other site 243160003640 MoaD interaction [polypeptide binding]; other site 243160003641 active site residues [active] 243160003642 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243160003643 MoaE interaction surface [polypeptide binding]; other site 243160003644 MoeB interaction surface [polypeptide binding]; other site 243160003645 thiocarboxylated glycine; other site 243160003646 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243160003647 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243160003648 dimer interface [polypeptide binding]; other site 243160003649 putative functional site; other site 243160003650 putative MPT binding site; other site 243160003651 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 243160003652 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 243160003653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160003654 catalytic residue [active] 243160003655 homoserine dehydrogenase; Provisional; Region: PRK06349 243160003656 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243160003657 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243160003658 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243160003659 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243160003660 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243160003661 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 243160003662 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243160003663 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243160003664 inhibitor-cofactor binding pocket; inhibition site 243160003665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160003666 catalytic residue [active] 243160003667 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 243160003668 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243160003669 Ligand binding site; other site 243160003670 Putative Catalytic site; other site 243160003671 DXD motif; other site 243160003672 putative formyltransferase; Provisional; Region: PRK06988 243160003673 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 243160003674 active site 243160003675 substrate binding site [chemical binding]; other site 243160003676 cosubstrate binding site; other site 243160003677 catalytic site [active] 243160003678 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 243160003679 active site 243160003680 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 243160003681 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 243160003682 NAD binding site [chemical binding]; other site 243160003683 substrate binding site [chemical binding]; other site 243160003684 active site 243160003685 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 243160003686 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 243160003687 putative active site [active] 243160003688 putative catalytic site [active] 243160003689 putative Zn binding site [ion binding]; other site 243160003690 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243160003691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160003692 catalytic triad [active] 243160003693 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 243160003694 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 243160003695 putative active site [active] 243160003696 PhoH-like protein; Region: PhoH; pfam02562 243160003697 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243160003698 NlpC/P60 family; Region: NLPC_P60; pfam00877 243160003699 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243160003700 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 243160003701 replicative DNA helicase; Provisional; Region: PRK07004 243160003702 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243160003703 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243160003704 Walker A motif; other site 243160003705 ATP binding site [chemical binding]; other site 243160003706 Walker B motif; other site 243160003707 DNA binding loops [nucleotide binding] 243160003708 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243160003709 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243160003710 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243160003711 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 243160003712 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 243160003713 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 243160003714 Putative zinc-finger; Region: zf-HC2; pfam13490 243160003715 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 243160003716 RNA polymerase sigma factor; Provisional; Region: PRK12533 243160003717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160003718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160003719 DNA binding residues [nucleotide binding] 243160003720 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160003721 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160003722 active site 243160003723 metal binding site [ion binding]; metal-binding site 243160003724 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243160003725 HTH-like domain; Region: HTH_21; pfam13276 243160003726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003727 Integrase core domain; Region: rve; pfam00665 243160003728 Integrase core domain; Region: rve_3; pfam13683 243160003729 Transposase; Region: HTH_Tnp_1; pfam01527 243160003730 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 243160003731 active site 243160003732 homodimer interface [polypeptide binding]; other site 243160003733 homotetramer interface [polypeptide binding]; other site 243160003734 psiF repeat; Region: PsiF_repeat; pfam07769 243160003735 psiF repeat; Region: PsiF_repeat; pfam07769 243160003736 Domain of unknown function DUF221; Region: DUF221; pfam02714 243160003737 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 243160003738 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243160003739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160003740 putative ADP-binding pocket [chemical binding]; other site 243160003741 Predicted ATPase [General function prediction only]; Region: COG4637 243160003742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160003743 Walker A/P-loop; other site 243160003744 ATP binding site [chemical binding]; other site 243160003745 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243160003746 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243160003747 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243160003748 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243160003749 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243160003750 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243160003751 active site 243160003752 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 243160003753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160003754 Coenzyme A binding pocket [chemical binding]; other site 243160003755 DNA polymerase III subunit delta'; Validated; Region: PRK06964 243160003756 DNA polymerase III subunit delta'; Validated; Region: PRK08485 243160003757 thymidylate kinase; Validated; Region: tmk; PRK00698 243160003758 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243160003759 TMP-binding site; other site 243160003760 ATP-binding site [chemical binding]; other site 243160003761 YceG-like family; Region: YceG; pfam02618 243160003762 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 243160003763 dimerization interface [polypeptide binding]; other site 243160003764 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 243160003765 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 243160003766 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243160003767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160003768 Coenzyme A binding pocket [chemical binding]; other site 243160003769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243160003770 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243160003771 substrate binding pocket [chemical binding]; other site 243160003772 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 243160003773 Prostaglandin dehydrogenases; Region: PGDH; cd05288 243160003774 NAD(P) binding site [chemical binding]; other site 243160003775 substrate binding site [chemical binding]; other site 243160003776 dimer interface [polypeptide binding]; other site 243160003777 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160003778 CoenzymeA binding site [chemical binding]; other site 243160003779 subunit interaction site [polypeptide binding]; other site 243160003780 PHB binding site; other site 243160003781 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 243160003782 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160003783 dimer interface [polypeptide binding]; other site 243160003784 active site 243160003785 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 243160003786 catalytic triad [active] 243160003787 metal binding site [ion binding]; metal-binding site 243160003788 conserved cis-peptide bond; other site 243160003789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160003790 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 243160003791 substrate binding site [chemical binding]; other site 243160003792 oxyanion hole (OAH) forming residues; other site 243160003793 trimer interface [polypeptide binding]; other site 243160003794 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243160003795 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160003796 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160003797 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 243160003798 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 243160003799 dimer interface [polypeptide binding]; other site 243160003800 acyl-activating enzyme (AAE) consensus motif; other site 243160003801 putative active site [active] 243160003802 AMP binding site [chemical binding]; other site 243160003803 putative CoA binding site [chemical binding]; other site 243160003804 Uncharacterized conserved protein [Function unknown]; Region: COG0397 243160003805 hypothetical protein; Validated; Region: PRK00029 243160003806 SelR domain; Region: SelR; pfam01641 243160003807 methionine sulfoxide reductase B; Provisional; Region: PRK00222 243160003808 intracellular septation protein A; Reviewed; Region: PRK00259 243160003809 BolA-like protein; Region: BolA; pfam01722 243160003810 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 243160003811 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243160003812 Predicted acetyltransferase [General function prediction only]; Region: COG3153 243160003813 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 243160003814 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 243160003815 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243160003816 dimerization interface [polypeptide binding]; other site 243160003817 ATP binding site [chemical binding]; other site 243160003818 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243160003819 dimerization interface [polypeptide binding]; other site 243160003820 ATP binding site [chemical binding]; other site 243160003821 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 243160003822 putative active site [active] 243160003823 catalytic triad [active] 243160003824 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 243160003825 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 243160003826 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243160003827 putative substrate binding site [chemical binding]; other site 243160003828 putative ATP binding site [chemical binding]; other site 243160003829 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 243160003830 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243160003831 active site 243160003832 dimer interface [polypeptide binding]; other site 243160003833 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243160003834 dimer interface [polypeptide binding]; other site 243160003835 active site 243160003836 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 243160003837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243160003838 Walker A/P-loop; other site 243160003839 ATP binding site [chemical binding]; other site 243160003840 Q-loop/lid; other site 243160003841 ABC transporter signature motif; other site 243160003842 Walker B; other site 243160003843 D-loop; other site 243160003844 H-loop/switch region; other site 243160003845 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 243160003846 active site 243160003847 catalytic triad [active] 243160003848 oxyanion hole [active] 243160003849 switch loop; other site 243160003850 SurA N-terminal domain; Region: SurA_N_3; cl07813 243160003851 periplasmic folding chaperone; Provisional; Region: PRK10788 243160003852 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243160003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 243160003854 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243160003855 30S subunit binding site; other site 243160003856 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243160003857 Found in ATP-dependent protease La (LON); Region: LON; smart00464 243160003858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003859 Walker A motif; other site 243160003860 ATP binding site [chemical binding]; other site 243160003861 Walker B motif; other site 243160003862 arginine finger; other site 243160003863 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243160003864 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243160003865 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243160003866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160003867 Walker A motif; other site 243160003868 ATP binding site [chemical binding]; other site 243160003869 Walker B motif; other site 243160003870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243160003871 Clp protease; Region: CLP_protease; pfam00574 243160003872 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243160003873 oligomer interface [polypeptide binding]; other site 243160003874 active site residues [active] 243160003875 trigger factor; Provisional; Region: tig; PRK01490 243160003876 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243160003877 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243160003878 Glycerate kinase family; Region: Gly_kinase; cl00841 243160003879 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160003880 MarR family; Region: MarR_2; pfam12802 243160003881 MarR family; Region: MarR_2; cl17246 243160003882 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 243160003883 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243160003884 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243160003885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160003886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160003887 dimerization interface [polypeptide binding]; other site 243160003888 DNA binding residues [nucleotide binding] 243160003889 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160003890 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160003891 trimer interface [polypeptide binding]; other site 243160003892 eyelet of channel; other site 243160003893 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 243160003894 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243160003895 active site 243160003896 Zn binding site [ion binding]; other site 243160003897 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 243160003898 PLD-like domain; Region: PLDc_2; pfam13091 243160003899 putative active site [active] 243160003900 catalytic site [active] 243160003901 HTH-like domain; Region: HTH_21; pfam13276 243160003902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160003903 Integrase core domain; Region: rve; pfam00665 243160003904 Integrase core domain; Region: rve_3; pfam13683 243160003905 Transposase; Region: HTH_Tnp_1; pfam01527 243160003906 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243160003907 active site lid residues [active] 243160003908 substrate binding pocket [chemical binding]; other site 243160003909 catalytic residues [active] 243160003910 substrate-Mg2+ binding site; other site 243160003911 aspartate-rich region 1; other site 243160003912 aspartate-rich region 2; other site 243160003913 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 243160003914 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 243160003915 osmolarity response regulator; Provisional; Region: ompR; PRK09468 243160003916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160003917 active site 243160003918 phosphorylation site [posttranslational modification] 243160003919 intermolecular recognition site; other site 243160003920 dimerization interface [polypeptide binding]; other site 243160003921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160003922 DNA binding site [nucleotide binding] 243160003923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160003924 HAMP domain; Region: HAMP; pfam00672 243160003925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160003926 dimer interface [polypeptide binding]; other site 243160003927 phosphorylation site [posttranslational modification] 243160003928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160003929 ATP binding site [chemical binding]; other site 243160003930 Mg2+ binding site [ion binding]; other site 243160003931 G-X-G motif; other site 243160003932 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243160003933 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243160003934 dimer interface [polypeptide binding]; other site 243160003935 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243160003936 catalytic triad [active] 243160003937 peroxidatic and resolving cysteines [active] 243160003938 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 243160003939 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243160003940 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243160003941 homotrimer interaction site [polypeptide binding]; other site 243160003942 zinc binding site [ion binding]; other site 243160003943 CDP-binding sites; other site 243160003944 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243160003945 substrate binding site; other site 243160003946 dimer interface; other site 243160003947 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 243160003948 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 243160003949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160003950 ATP binding site [chemical binding]; other site 243160003951 putative Mg++ binding site [ion binding]; other site 243160003952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160003953 nucleotide binding region [chemical binding]; other site 243160003954 ATP-binding site [chemical binding]; other site 243160003955 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 243160003956 acetylornithine deacetylase; Provisional; Region: PRK07522 243160003957 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 243160003958 metal binding site [ion binding]; metal-binding site 243160003959 putative dimer interface [polypeptide binding]; other site 243160003960 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243160003961 tetramer interface [polypeptide binding]; other site 243160003962 hypothetical protein; Provisional; Region: PRK06815 243160003963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160003964 catalytic residue [active] 243160003965 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 243160003966 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 243160003967 Transglycosylase; Region: Transgly; pfam00912 243160003968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243160003969 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 243160003970 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 243160003971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243160003972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160003973 TPR motif; other site 243160003974 Transposase domain (DUF772); Region: DUF772; pfam05598 243160003975 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160003976 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160003977 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 243160003978 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 243160003979 Transposase domain (DUF772); Region: DUF772; pfam05598 243160003980 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160003981 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160003982 ureidoglycolate hydrolase; Provisional; Region: PRK03606 243160003983 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 243160003984 allantoicase; Provisional; Region: PRK13257 243160003985 Allantoicase repeat; Region: Allantoicase; pfam03561 243160003986 Allantoicase repeat; Region: Allantoicase; pfam03561 243160003987 OHCU decarboxylase; Region: UHCUDC; TIGR03164 243160003988 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 243160003989 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 243160003990 active site 243160003991 catalytic site [active] 243160003992 tetramer interface [polypeptide binding]; other site 243160003993 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 243160003994 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 243160003995 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 243160003996 Na binding site [ion binding]; other site 243160003997 putative substrate binding site [chemical binding]; other site 243160003998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243160003999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160004000 DNA-binding site [nucleotide binding]; DNA binding site 243160004001 FCD domain; Region: FCD; pfam07729 243160004002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160004003 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160004004 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 243160004005 dimer interface [polypeptide binding]; other site 243160004006 catalytic triad [active] 243160004007 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243160004008 nucleoside/Zn binding site; other site 243160004009 dimer interface [polypeptide binding]; other site 243160004010 catalytic motif [active] 243160004011 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 243160004012 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 243160004013 GMP synthase; Reviewed; Region: guaA; PRK00074 243160004014 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243160004015 AMP/PPi binding site [chemical binding]; other site 243160004016 candidate oxyanion hole; other site 243160004017 catalytic triad [active] 243160004018 potential glutamine specificity residues [chemical binding]; other site 243160004019 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243160004020 ATP Binding subdomain [chemical binding]; other site 243160004021 Ligand Binding sites [chemical binding]; other site 243160004022 Dimerization subdomain; other site 243160004023 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243160004024 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243160004025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243160004026 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243160004027 active site 243160004028 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 243160004029 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 243160004030 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160004031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 243160004032 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 243160004033 putative coenzyme Q binding site [chemical binding]; other site 243160004034 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243160004035 SmpB-tmRNA interface; other site 243160004036 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243160004037 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 243160004038 phosphoenolpyruvate synthase; Validated; Region: PRK06464 243160004039 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243160004040 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243160004041 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243160004042 Phytochelatin synthase; Region: Phytochelatin; pfam05023 243160004043 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 243160004044 peptidase domain interface [polypeptide binding]; other site 243160004045 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 243160004046 active site 243160004047 catalytic triad [active] 243160004048 calcium binding site [ion binding]; other site 243160004049 PEP synthetase regulatory protein; Provisional; Region: PRK05339 243160004050 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243160004051 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243160004052 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 243160004053 RNA/DNA hybrid binding site [nucleotide binding]; other site 243160004054 active site 243160004055 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 243160004056 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 243160004057 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243160004058 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243160004059 active site 243160004060 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243160004061 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 243160004062 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 243160004063 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 243160004064 trimer interface [polypeptide binding]; other site 243160004065 active site 243160004066 UDP-GlcNAc binding site [chemical binding]; other site 243160004067 lipid binding site [chemical binding]; lipid-binding site 243160004068 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 243160004069 periplasmic chaperone; Provisional; Region: PRK10780 243160004070 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 243160004071 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160004072 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160004073 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160004074 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160004075 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160004076 Surface antigen; Region: Bac_surface_Ag; pfam01103 243160004077 zinc metallopeptidase RseP; Provisional; Region: PRK10779 243160004078 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243160004079 active site 243160004080 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243160004081 protein binding site [polypeptide binding]; other site 243160004082 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243160004083 putative substrate binding region [chemical binding]; other site 243160004084 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243160004085 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 243160004086 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243160004087 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243160004088 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243160004089 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 243160004090 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 243160004091 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 243160004092 catalytic residue [active] 243160004093 putative FPP diphosphate binding site; other site 243160004094 putative FPP binding hydrophobic cleft; other site 243160004095 dimer interface [polypeptide binding]; other site 243160004096 putative IPP diphosphate binding site; other site 243160004097 ribosome recycling factor; Reviewed; Region: frr; PRK00083 243160004098 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243160004099 hinge region; other site 243160004100 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243160004101 putative nucleotide binding site [chemical binding]; other site 243160004102 uridine monophosphate binding site [chemical binding]; other site 243160004103 homohexameric interface [polypeptide binding]; other site 243160004104 elongation factor Ts; Provisional; Region: tsf; PRK09377 243160004105 UBA/TS-N domain; Region: UBA; pfam00627 243160004106 Elongation factor TS; Region: EF_TS; pfam00889 243160004107 Elongation factor TS; Region: EF_TS; pfam00889 243160004108 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243160004109 rRNA interaction site [nucleotide binding]; other site 243160004110 S8 interaction site; other site 243160004111 putative laminin-1 binding site; other site 243160004112 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243160004113 active site 243160004114 PII uridylyl-transferase; Provisional; Region: PRK03059 243160004115 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243160004116 metal binding triad; other site 243160004117 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243160004118 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243160004119 Zn2+ binding site [ion binding]; other site 243160004120 Mg2+ binding site [ion binding]; other site 243160004121 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 243160004122 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 243160004123 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243160004124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160004125 RNA binding surface [nucleotide binding]; other site 243160004126 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243160004127 active site 243160004128 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243160004129 active site 243160004130 catalytic residues [active] 243160004131 metal binding site [ion binding]; metal-binding site 243160004132 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243160004133 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243160004134 nucleotide binding pocket [chemical binding]; other site 243160004135 K-X-D-G motif; other site 243160004136 catalytic site [active] 243160004137 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243160004138 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243160004139 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243160004140 Dimer interface [polypeptide binding]; other site 243160004141 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 243160004142 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243160004143 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243160004144 Walker A/P-loop; other site 243160004145 ATP binding site [chemical binding]; other site 243160004146 Q-loop/lid; other site 243160004147 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243160004148 Q-loop/lid; other site 243160004149 ABC transporter signature motif; other site 243160004150 Walker B; other site 243160004151 D-loop; other site 243160004152 H-loop/switch region; other site 243160004153 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160004154 EamA-like transporter family; Region: EamA; pfam00892 243160004155 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 243160004156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160004157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160004158 homodimer interface [polypeptide binding]; other site 243160004159 catalytic residue [active] 243160004160 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 243160004161 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 243160004162 trimer interface [polypeptide binding]; other site 243160004163 active site 243160004164 substrate binding site [chemical binding]; other site 243160004165 CoA binding site [chemical binding]; other site 243160004166 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 243160004167 ArsC family; Region: ArsC; pfam03960 243160004168 putative catalytic residues [active] 243160004169 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 243160004170 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 243160004171 metal binding site [ion binding]; metal-binding site 243160004172 dimer interface [polypeptide binding]; other site 243160004173 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 243160004174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160004175 S-adenosylmethionine binding site [chemical binding]; other site 243160004176 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 243160004177 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 243160004178 putative active site [active] 243160004179 catalytic site [active] 243160004180 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 243160004181 putative active site [active] 243160004182 catalytic site [active] 243160004183 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 243160004184 catalytic residues [active] 243160004185 dimer interface [polypeptide binding]; other site 243160004186 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 243160004187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160004188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160004189 ABC transporter; Region: ABC_tran_2; pfam12848 243160004190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160004191 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 243160004192 DNA repair protein RadA; Provisional; Region: PRK11823 243160004193 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 243160004194 Walker A motif/ATP binding site; other site 243160004195 ATP binding site [chemical binding]; other site 243160004196 Walker B motif; other site 243160004197 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243160004198 alanine racemase; Reviewed; Region: dadX; PRK03646 243160004199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 243160004200 active site 243160004201 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160004202 substrate binding site [chemical binding]; other site 243160004203 catalytic residues [active] 243160004204 dimer interface [polypeptide binding]; other site 243160004205 lysophospholipid transporter LplT; Provisional; Region: PRK11195 243160004206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160004207 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243160004208 dimer interface [polypeptide binding]; other site 243160004209 substrate binding site [chemical binding]; other site 243160004210 ATP binding site [chemical binding]; other site 243160004211 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 243160004212 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243160004213 Fe-S cluster binding site [ion binding]; other site 243160004214 active site 243160004215 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243160004216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160004217 Coenzyme A binding pocket [chemical binding]; other site 243160004218 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243160004219 Glycoprotease family; Region: Peptidase_M22; pfam00814 243160004220 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 243160004221 acyl-CoA binding pocket [chemical binding]; other site 243160004222 CoA binding site [chemical binding]; other site 243160004223 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243160004224 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243160004225 ATP binding site [chemical binding]; other site 243160004226 Mg++ binding site [ion binding]; other site 243160004227 motif III; other site 243160004228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160004229 nucleotide binding region [chemical binding]; other site 243160004230 ATP-binding site [chemical binding]; other site 243160004231 Transposase domain (DUF772); Region: DUF772; pfam05598 243160004232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160004233 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160004234 isocitrate lyase; Provisional; Region: PRK15063 243160004235 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243160004236 tetramer interface [polypeptide binding]; other site 243160004237 active site 243160004238 Mg2+/Mn2+ binding site [ion binding]; other site 243160004239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160004240 Ligand Binding Site [chemical binding]; other site 243160004241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160004242 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160004243 putative effector binding pocket; other site 243160004244 dimerization interface [polypeptide binding]; other site 243160004245 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 243160004246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160004247 motif II; other site 243160004248 malate synthase A; Region: malate_syn_A; TIGR01344 243160004249 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 243160004250 active site 243160004251 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243160004252 putative active site pocket [active] 243160004253 dimerization interface [polypeptide binding]; other site 243160004254 putative catalytic residue [active] 243160004255 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 243160004256 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160004257 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160004258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160004259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160004260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160004261 Coenzyme A binding pocket [chemical binding]; other site 243160004262 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243160004263 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243160004264 active site 243160004265 HIGH motif; other site 243160004266 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243160004267 active site 243160004268 KMSKS motif; other site 243160004269 hypothetical protein; Provisional; Region: PRK10279 243160004270 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 243160004271 nucleophile elbow; other site 243160004272 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243160004273 NlpC/P60 family; Region: NLPC_P60; pfam00877 243160004274 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 243160004275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160004276 Walker A/P-loop; other site 243160004277 ATP binding site [chemical binding]; other site 243160004278 Q-loop/lid; other site 243160004279 ABC transporter signature motif; other site 243160004280 Walker B; other site 243160004281 D-loop; other site 243160004282 H-loop/switch region; other site 243160004283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160004284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160004285 Walker A/P-loop; other site 243160004286 ATP binding site [chemical binding]; other site 243160004287 Q-loop/lid; other site 243160004288 ABC transporter signature motif; other site 243160004289 Walker B; other site 243160004290 D-loop; other site 243160004291 H-loop/switch region; other site 243160004292 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160004293 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 243160004294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160004295 dimer interface [polypeptide binding]; other site 243160004296 conserved gate region; other site 243160004297 putative PBP binding loops; other site 243160004298 ABC-ATPase subunit interface; other site 243160004299 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 243160004300 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 243160004301 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 243160004302 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243160004303 NAD binding site [chemical binding]; other site 243160004304 homotetramer interface [polypeptide binding]; other site 243160004305 homodimer interface [polypeptide binding]; other site 243160004306 substrate binding site [chemical binding]; other site 243160004307 active site 243160004308 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243160004309 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 243160004310 putative [Fe4-S4] binding site [ion binding]; other site 243160004311 putative molybdopterin cofactor binding site [chemical binding]; other site 243160004312 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160004313 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 243160004314 putative molybdopterin cofactor binding site; other site 243160004315 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 243160004316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160004317 FeS/SAM binding site; other site 243160004318 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243160004319 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243160004320 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 243160004321 FAD binding pocket [chemical binding]; other site 243160004322 FAD binding motif [chemical binding]; other site 243160004323 phosphate binding motif [ion binding]; other site 243160004324 beta-alpha-beta structure motif; other site 243160004325 NAD binding pocket [chemical binding]; other site 243160004326 Ferredoxin [Energy production and conversion]; Region: COG1146 243160004327 4Fe-4S binding domain; Region: Fer4; cl02805 243160004328 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243160004329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160004330 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243160004331 active site 243160004332 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 243160004333 argininosuccinate lyase; Provisional; Region: PRK02186 243160004334 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 243160004335 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243160004336 active sites [active] 243160004337 tetramer interface [polypeptide binding]; other site 243160004338 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243160004339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160004340 catalytic residue [active] 243160004341 dimer interface [polypeptide binding]; other site 243160004342 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 243160004343 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243160004344 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243160004345 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243160004346 Active Sites [active] 243160004347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160004348 active site 243160004349 phosphoserine aminotransferase; Provisional; Region: PRK12462 243160004350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160004351 catalytic residue [active] 243160004352 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160004353 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 243160004354 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243160004355 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 243160004356 PYR/PP interface [polypeptide binding]; other site 243160004357 dimer interface [polypeptide binding]; other site 243160004358 TPP binding site [chemical binding]; other site 243160004359 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243160004360 TPP-binding site [chemical binding]; other site 243160004361 dimer interface [polypeptide binding]; other site 243160004362 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243160004363 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160004364 active site 243160004365 iron coordination sites [ion binding]; other site 243160004366 substrate binding pocket [chemical binding]; other site 243160004367 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 243160004368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 243160004369 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 243160004370 Transmembrane secretion effector; Region: MFS_3; pfam05977 243160004371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160004372 putative substrate translocation pore; other site 243160004373 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160004374 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160004375 acyl-activating enzyme (AAE) consensus motif; other site 243160004376 AMP binding site [chemical binding]; other site 243160004377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160004378 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243160004379 ligand-binding site [chemical binding]; other site 243160004380 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243160004381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160004382 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160004383 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 243160004384 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 243160004385 active site 243160004386 catalytic triad [active] 243160004387 oxyanion hole [active] 243160004388 Autotransporter beta-domain; Region: Autotransporter; smart00869 243160004389 aspartate kinase; Reviewed; Region: PRK06635 243160004390 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243160004391 putative nucleotide binding site [chemical binding]; other site 243160004392 putative catalytic residues [active] 243160004393 putative Mg ion binding site [ion binding]; other site 243160004394 putative aspartate binding site [chemical binding]; other site 243160004395 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243160004396 putative allosteric regulatory site; other site 243160004397 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 243160004398 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243160004399 Ligand Binding Site [chemical binding]; other site 243160004400 TilS substrate binding domain; Region: TilS; pfam09179 243160004401 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 243160004402 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 243160004403 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 243160004404 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243160004405 endonuclease III; Region: ENDO3c; smart00478 243160004406 minor groove reading motif; other site 243160004407 helix-hairpin-helix signature motif; other site 243160004408 substrate binding pocket [chemical binding]; other site 243160004409 active site 243160004410 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243160004411 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243160004412 active site 243160004413 HIGH motif; other site 243160004414 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243160004415 KMSKS motif; other site 243160004416 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 243160004417 tRNA binding surface [nucleotide binding]; other site 243160004418 anticodon binding site; other site 243160004419 TPR repeat; Region: TPR_11; pfam13414 243160004420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160004421 binding surface 243160004422 TPR motif; other site 243160004423 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243160004424 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243160004425 substrate binding site [chemical binding]; other site 243160004426 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243160004427 substrate binding site [chemical binding]; other site 243160004428 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160004429 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243160004430 putative active site [active] 243160004431 putative metal binding site [ion binding]; other site 243160004432 serine O-acetyltransferase; Region: cysE; TIGR01172 243160004433 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243160004434 trimer interface [polypeptide binding]; other site 243160004435 active site 243160004436 substrate binding site [chemical binding]; other site 243160004437 CoA binding site [chemical binding]; other site 243160004438 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 243160004439 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 243160004440 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243160004441 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243160004442 active site 243160004443 dimerization interface [polypeptide binding]; other site 243160004444 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 243160004445 MutS domain I; Region: MutS_I; pfam01624 243160004446 MutS domain II; Region: MutS_II; pfam05188 243160004447 MutS domain III; Region: MutS_III; pfam05192 243160004448 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 243160004449 Walker A/P-loop; other site 243160004450 ATP binding site [chemical binding]; other site 243160004451 Q-loop/lid; other site 243160004452 ABC transporter signature motif; other site 243160004453 Walker B; other site 243160004454 D-loop; other site 243160004455 H-loop/switch region; other site 243160004456 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 243160004457 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 243160004458 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243160004459 dihydrodipicolinate synthase; Region: dapA; TIGR00674 243160004460 dimer interface [polypeptide binding]; other site 243160004461 active site 243160004462 catalytic residue [active] 243160004463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160004464 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243160004465 active site 243160004466 HIGH motif; other site 243160004467 dimer interface [polypeptide binding]; other site 243160004468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160004469 active site 243160004470 KMSKS motif; other site 243160004471 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 243160004472 Peptidase family M50; Region: Peptidase_M50; pfam02163 243160004473 active site 243160004474 putative substrate binding region [chemical binding]; other site 243160004475 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 243160004476 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 243160004477 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243160004478 active site 243160004479 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243160004480 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160004481 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160004482 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 243160004483 catalytic site [active] 243160004484 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243160004485 dinuclear metal binding motif [ion binding]; other site 243160004486 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243160004487 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243160004488 trimer interface [polypeptide binding]; other site 243160004489 putative metal binding site [ion binding]; other site 243160004490 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 243160004491 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 243160004492 dimerization interface [polypeptide binding]; other site 243160004493 domain crossover interface; other site 243160004494 redox-dependent activation switch; other site 243160004495 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 243160004496 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 243160004497 enolase; Provisional; Region: eno; PRK00077 243160004498 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243160004499 dimer interface [polypeptide binding]; other site 243160004500 metal binding site [ion binding]; metal-binding site 243160004501 substrate binding pocket [chemical binding]; other site 243160004502 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 243160004503 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243160004504 CTP synthetase; Validated; Region: pyrG; PRK05380 243160004505 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243160004506 Catalytic site [active] 243160004507 active site 243160004508 UTP binding site [chemical binding]; other site 243160004509 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243160004510 active site 243160004511 putative oxyanion hole; other site 243160004512 catalytic triad [active] 243160004513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160004514 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 243160004515 nucleophilic elbow; other site 243160004516 catalytic triad; other site 243160004517 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 243160004518 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 243160004519 Competence protein; Region: Competence; pfam03772 243160004520 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 243160004521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243160004522 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243160004523 active site 243160004524 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 243160004525 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243160004526 Walker A/P-loop; other site 243160004527 ATP binding site [chemical binding]; other site 243160004528 Q-loop/lid; other site 243160004529 ABC transporter signature motif; other site 243160004530 Walker B; other site 243160004531 D-loop; other site 243160004532 H-loop/switch region; other site 243160004533 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 243160004534 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243160004535 FtsX-like permease family; Region: FtsX; pfam02687 243160004536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 243160004537 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 243160004538 DHH family; Region: DHH; pfam01368 243160004539 DHHA1 domain; Region: DHHA1; pfam02272 243160004540 peptide chain release factor 2; Validated; Region: prfB; PRK00578 243160004541 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243160004542 RF-1 domain; Region: RF-1; pfam00472 243160004543 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243160004544 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243160004545 dimer interface [polypeptide binding]; other site 243160004546 putative anticodon binding site; other site 243160004547 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243160004548 motif 1; other site 243160004549 active site 243160004550 motif 2; other site 243160004551 motif 3; other site 243160004552 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 243160004553 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243160004554 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160004555 catalytic loop [active] 243160004556 iron binding site [ion binding]; other site 243160004557 chaperone protein HscA; Provisional; Region: hscA; PRK05183 243160004558 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 243160004559 nucleotide binding site [chemical binding]; other site 243160004560 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243160004561 SBD interface [polypeptide binding]; other site 243160004562 co-chaperone HscB; Provisional; Region: hscB; PRK03578 243160004563 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243160004564 HSP70 interaction site [polypeptide binding]; other site 243160004565 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 243160004566 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 243160004567 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243160004568 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243160004569 trimerization site [polypeptide binding]; other site 243160004570 active site 243160004571 cysteine desulfurase; Provisional; Region: PRK14012 243160004572 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243160004573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160004574 catalytic residue [active] 243160004575 Predicted transcriptional regulator [Transcription]; Region: COG1959 243160004576 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 243160004577 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243160004578 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 243160004579 active site 243160004580 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 243160004581 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243160004582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243160004583 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 243160004584 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243160004585 Cysteine-rich domain; Region: CCG; pfam02754 243160004586 Cysteine-rich domain; Region: CCG; pfam02754 243160004587 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160004588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160004589 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160004590 Transposase domain (DUF772); Region: DUF772; pfam05598 243160004591 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160004592 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160004593 Phasin protein; Region: Phasin_2; pfam09361 243160004594 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243160004595 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243160004596 Transposase domain (DUF772); Region: DUF772; pfam05598 243160004597 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160004598 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160004599 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160004600 E3 interaction surface; other site 243160004601 lipoyl attachment site [posttranslational modification]; other site 243160004602 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 243160004603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160004604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160004605 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243160004606 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 243160004607 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160004608 E3 interaction surface; other site 243160004609 lipoyl attachment site [posttranslational modification]; other site 243160004610 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160004611 E3 interaction surface; other site 243160004612 lipoyl attachment site [posttranslational modification]; other site 243160004613 e3 binding domain; Region: E3_binding; pfam02817 243160004614 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243160004615 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 243160004616 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 243160004617 dimer interface [polypeptide binding]; other site 243160004618 TPP-binding site [chemical binding]; other site 243160004619 PAS domain S-box; Region: sensory_box; TIGR00229 243160004620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160004621 putative active site [active] 243160004622 heme pocket [chemical binding]; other site 243160004623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160004624 dimer interface [polypeptide binding]; other site 243160004625 phosphorylation site [posttranslational modification] 243160004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160004627 ATP binding site [chemical binding]; other site 243160004628 Mg2+ binding site [ion binding]; other site 243160004629 G-X-G motif; other site 243160004630 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 243160004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160004632 active site 243160004633 phosphorylation site [posttranslational modification] 243160004634 intermolecular recognition site; other site 243160004635 dimerization interface [polypeptide binding]; other site 243160004636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160004637 DNA binding residues [nucleotide binding] 243160004638 dimerization interface [polypeptide binding]; other site 243160004639 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 243160004640 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243160004641 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243160004642 homodimer interface [polypeptide binding]; other site 243160004643 NADP binding site [chemical binding]; other site 243160004644 substrate binding site [chemical binding]; other site 243160004645 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 243160004646 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 243160004647 active site 243160004648 Zn binding site [ion binding]; other site 243160004649 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243160004650 active site 243160004651 DNA polymerase IV; Validated; Region: PRK02406 243160004652 DNA binding site [nucleotide binding] 243160004653 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243160004654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160004655 putative substrate translocation pore; other site 243160004656 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 243160004657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160004658 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 243160004659 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 243160004660 [4Fe-4S] binding site [ion binding]; other site 243160004661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160004662 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160004663 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160004664 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 243160004665 molybdopterin cofactor binding site; other site 243160004666 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 243160004667 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 243160004668 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 243160004669 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 243160004670 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 243160004671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160004672 dimerization interface [polypeptide binding]; other site 243160004673 GAF domain; Region: GAF; pfam01590 243160004674 Histidine kinase; Region: HisKA_3; pfam07730 243160004675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160004676 ATP binding site [chemical binding]; other site 243160004677 Mg2+ binding site [ion binding]; other site 243160004678 G-X-G motif; other site 243160004679 transcriptional regulator NarL; Provisional; Region: PRK10651 243160004680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160004681 active site 243160004682 phosphorylation site [posttranslational modification] 243160004683 intermolecular recognition site; other site 243160004684 dimerization interface [polypeptide binding]; other site 243160004685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160004686 DNA binding residues [nucleotide binding] 243160004687 dimerization interface [polypeptide binding]; other site 243160004688 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 243160004689 putative catalytic site [active] 243160004690 putative phosphate binding site [ion binding]; other site 243160004691 active site 243160004692 metal binding site A [ion binding]; metal-binding site 243160004693 DNA binding site [nucleotide binding] 243160004694 putative AP binding site [nucleotide binding]; other site 243160004695 putative metal binding site B [ion binding]; other site 243160004696 Transposase domain (DUF772); Region: DUF772; pfam05598 243160004697 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160004698 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160004699 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 243160004700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160004701 active site 243160004702 phosphorylation site [posttranslational modification] 243160004703 intermolecular recognition site; other site 243160004704 dimerization interface [polypeptide binding]; other site 243160004705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160004706 Walker A motif; other site 243160004707 ATP binding site [chemical binding]; other site 243160004708 Walker B motif; other site 243160004709 arginine finger; other site 243160004710 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160004711 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243160004712 PAS domain; Region: PAS; smart00091 243160004713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160004714 dimer interface [polypeptide binding]; other site 243160004715 phosphorylation site [posttranslational modification] 243160004716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160004717 ATP binding site [chemical binding]; other site 243160004718 Mg2+ binding site [ion binding]; other site 243160004719 G-X-G motif; other site 243160004720 Transposase domain (DUF772); Region: DUF772; pfam05598 243160004721 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160004722 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160004723 glutamine synthetase; Provisional; Region: glnA; PRK09469 243160004724 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243160004725 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243160004726 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 243160004727 active site residue [active] 243160004728 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 243160004729 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243160004730 putative MPT binding site; other site 243160004731 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 243160004732 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 243160004733 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 243160004734 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 243160004735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160004736 ATP binding site [chemical binding]; other site 243160004737 putative Mg++ binding site [ion binding]; other site 243160004738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160004739 nucleotide binding region [chemical binding]; other site 243160004740 ATP-binding site [chemical binding]; other site 243160004741 Helicase associated domain (HA2); Region: HA2; pfam04408 243160004742 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 243160004743 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 243160004744 N-acetylglutamate synthase; Validated; Region: PRK05279 243160004745 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 243160004746 putative feedback inhibition sensing region; other site 243160004747 putative nucleotide binding site [chemical binding]; other site 243160004748 putative substrate binding site [chemical binding]; other site 243160004749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160004750 Coenzyme A binding pocket [chemical binding]; other site 243160004751 oxidative damage protection protein; Provisional; Region: PRK05408 243160004752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160004753 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160004754 putative substrate translocation pore; other site 243160004755 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243160004756 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243160004757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160004758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160004759 active site 243160004760 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 243160004761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160004762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160004763 dimerization interface [polypeptide binding]; other site 243160004764 HTH-like domain; Region: HTH_21; pfam13276 243160004765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160004766 Integrase core domain; Region: rve; pfam00665 243160004767 Integrase core domain; Region: rve_3; pfam13683 243160004768 Transposase; Region: HTH_Tnp_1; pfam01527 243160004769 EamA-like transporter family; Region: EamA; pfam00892 243160004770 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243160004771 EamA-like transporter family; Region: EamA; pfam00892 243160004772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160004773 hypothetical protein; Provisional; Region: PRK09256 243160004774 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 243160004775 AAA domain; Region: AAA_30; pfam13604 243160004776 Family description; Region: UvrD_C_2; pfam13538 243160004777 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 243160004778 Family description; Region: UvrD_C_2; pfam13538 243160004779 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 243160004780 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 243160004781 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 243160004782 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 243160004783 transcription termination factor Rho; Provisional; Region: PRK12678 243160004784 Predicted membrane protein [Function unknown]; Region: COG1289 243160004785 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 243160004786 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 243160004787 putative proline-specific permease; Provisional; Region: proY; PRK10580 243160004788 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243160004789 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160004790 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 243160004791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160004792 dimer interface [polypeptide binding]; other site 243160004793 conserved gate region; other site 243160004794 putative PBP binding loops; other site 243160004795 ABC-ATPase subunit interface; other site 243160004796 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 243160004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160004798 dimer interface [polypeptide binding]; other site 243160004799 conserved gate region; other site 243160004800 putative PBP binding loops; other site 243160004801 ABC-ATPase subunit interface; other site 243160004802 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 243160004803 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 243160004804 Walker A/P-loop; other site 243160004805 ATP binding site [chemical binding]; other site 243160004806 Q-loop/lid; other site 243160004807 ABC transporter signature motif; other site 243160004808 Walker B; other site 243160004809 D-loop; other site 243160004810 H-loop/switch region; other site 243160004811 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160004812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160004813 putative DNA binding site [nucleotide binding]; other site 243160004814 putative Zn2+ binding site [ion binding]; other site 243160004815 AsnC family; Region: AsnC_trans_reg; pfam01037 243160004816 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 243160004817 NADH(P)-binding; Region: NAD_binding_10; pfam13460 243160004818 NAD binding site [chemical binding]; other site 243160004819 putative active site [active] 243160004820 substrate binding site [chemical binding]; other site 243160004821 Predicted transcriptional regulator [Transcription]; Region: COG1959 243160004822 Transcriptional regulator; Region: Rrf2; pfam02082 243160004823 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 243160004824 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160004825 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160004826 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 243160004827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160004828 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 243160004829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160004830 DNA binding residues [nucleotide binding] 243160004831 dimerization interface [polypeptide binding]; other site 243160004832 Predicted membrane protein [Function unknown]; Region: COG3235 243160004833 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 243160004834 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 243160004835 putative active site [active] 243160004836 Zn binding site [ion binding]; other site 243160004837 methionine aminotransferase; Validated; Region: PRK09082 243160004838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160004839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160004840 homodimer interface [polypeptide binding]; other site 243160004841 catalytic residue [active] 243160004842 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243160004843 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 243160004844 C-terminal domain interface [polypeptide binding]; other site 243160004845 dimer interface [polypeptide binding]; other site 243160004846 GSH binding site (G-site) [chemical binding]; other site 243160004847 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 243160004848 putative N-terminal domain interface [polypeptide binding]; other site 243160004849 putative dimer interface [polypeptide binding]; other site 243160004850 putative substrate binding pocket (H-site) [chemical binding]; other site 243160004851 enoyl-CoA hydratase; Provisional; Region: PRK07511 243160004852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160004853 substrate binding site [chemical binding]; other site 243160004854 oxyanion hole (OAH) forming residues; other site 243160004855 trimer interface [polypeptide binding]; other site 243160004856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 243160004857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160004858 catalytic core [active] 243160004859 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243160004860 putative active site [active] 243160004861 putative substrate binding site [chemical binding]; other site 243160004862 ATP binding site [chemical binding]; other site 243160004863 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160004864 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 243160004865 FAD binding site [chemical binding]; other site 243160004866 substrate binding site [chemical binding]; other site 243160004867 catalytic base [active] 243160004868 Right handed beta helix region; Region: Beta_helix; pfam13229 243160004869 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 243160004870 putative active site [active] 243160004871 putative catalytic site [active] 243160004872 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 243160004873 putative active site [active] 243160004874 putative catalytic site [active] 243160004875 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 243160004876 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243160004877 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243160004878 active site 243160004879 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 243160004880 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243160004881 dimer interface [polypeptide binding]; other site 243160004882 ADP-ribose binding site [chemical binding]; other site 243160004883 active site 243160004884 nudix motif; other site 243160004885 metal binding site [ion binding]; metal-binding site 243160004886 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 243160004887 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243160004888 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243160004889 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243160004890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243160004891 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243160004892 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243160004893 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243160004894 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 243160004895 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 243160004896 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 243160004897 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 243160004898 4Fe-4S binding domain; Region: Fer4; cl02805 243160004899 4Fe-4S binding domain; Region: Fer4; pfam00037 243160004900 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243160004901 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243160004902 NADH dehydrogenase subunit G; Validated; Region: PRK09129 243160004903 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160004904 catalytic loop [active] 243160004905 iron binding site [ion binding]; other site 243160004906 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243160004907 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 243160004908 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243160004909 SLBB domain; Region: SLBB; pfam10531 243160004910 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243160004911 NADH dehydrogenase subunit E; Validated; Region: PRK07539 243160004912 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243160004913 putative dimer interface [polypeptide binding]; other site 243160004914 [2Fe-2S] cluster binding site [ion binding]; other site 243160004915 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 243160004916 NADH dehydrogenase subunit D; Validated; Region: PRK06075 243160004917 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 243160004918 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 243160004919 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243160004920 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 243160004921 Preprotein translocase SecG subunit; Region: SecG; pfam03840 243160004922 triosephosphate isomerase; Provisional; Region: PRK14567 243160004923 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243160004924 substrate binding site [chemical binding]; other site 243160004925 dimer interface [polypeptide binding]; other site 243160004926 catalytic triad [active] 243160004927 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 243160004928 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 243160004929 NAD(P) binding site [chemical binding]; other site 243160004930 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 243160004931 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 243160004932 RNase E interface [polypeptide binding]; other site 243160004933 trimer interface [polypeptide binding]; other site 243160004934 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243160004935 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243160004936 RNase E interface [polypeptide binding]; other site 243160004937 trimer interface [polypeptide binding]; other site 243160004938 active site 243160004939 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243160004940 putative nucleic acid binding region [nucleotide binding]; other site 243160004941 G-X-X-G motif; other site 243160004942 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243160004943 RNA binding site [nucleotide binding]; other site 243160004944 domain interface; other site 243160004945 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243160004946 16S/18S rRNA binding site [nucleotide binding]; other site 243160004947 S13e-L30e interaction site [polypeptide binding]; other site 243160004948 25S rRNA binding site [nucleotide binding]; other site 243160004949 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243160004950 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 243160004951 putative ligand binding site [chemical binding]; other site 243160004952 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 243160004953 active site clefts [active] 243160004954 zinc binding site [ion binding]; other site 243160004955 dimer interface [polypeptide binding]; other site 243160004956 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243160004957 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243160004958 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243160004959 HTH-like domain; Region: HTH_21; pfam13276 243160004960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160004961 Integrase core domain; Region: rve; pfam00665 243160004962 Integrase core domain; Region: rve_3; pfam13683 243160004963 Transposase; Region: HTH_Tnp_1; pfam01527 243160004964 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243160004965 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243160004966 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 243160004967 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243160004968 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243160004969 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243160004970 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243160004971 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243160004972 putative valine binding site [chemical binding]; other site 243160004973 dimer interface [polypeptide binding]; other site 243160004974 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243160004975 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 243160004976 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160004977 PYR/PP interface [polypeptide binding]; other site 243160004978 dimer interface [polypeptide binding]; other site 243160004979 TPP binding site [chemical binding]; other site 243160004980 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160004981 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 243160004982 TPP-binding site [chemical binding]; other site 243160004983 dimer interface [polypeptide binding]; other site 243160004984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160004985 RNA polymerase factor sigma-70; Validated; Region: PRK09047 243160004986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160004987 DNA binding residues [nucleotide binding] 243160004988 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 243160004989 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160004990 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243160004991 putative active site [active] 243160004992 putative metal binding site [ion binding]; other site 243160004993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160004994 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 243160004995 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 243160004996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160004997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160004998 Bacterial transcriptional repressor; Region: TetR; pfam13972 243160004999 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 243160005000 glucose-1-dehydrogenase; Provisional; Region: PRK06947 243160005001 classical (c) SDRs; Region: SDR_c; cd05233 243160005002 NAD(P) binding site [chemical binding]; other site 243160005003 active site 243160005004 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243160005005 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243160005006 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160005007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005008 putative substrate translocation pore; other site 243160005009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160005010 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160005011 amidase; Provisional; Region: PRK07042 243160005012 Amidase; Region: Amidase; cl11426 243160005013 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 243160005014 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243160005015 apolar tunnel; other site 243160005016 heme binding site [chemical binding]; other site 243160005017 dimerization interface [polypeptide binding]; other site 243160005018 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 243160005019 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 243160005020 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 243160005021 Domain of unknown function (DUF333); Region: DUF333; pfam03891 243160005022 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 243160005023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160005024 active site 243160005025 phosphorylation site [posttranslational modification] 243160005026 intermolecular recognition site; other site 243160005027 dimerization interface [polypeptide binding]; other site 243160005028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160005029 DNA binding site [nucleotide binding] 243160005030 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 243160005031 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243160005032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243160005033 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243160005034 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 243160005035 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 243160005036 NADP binding site [chemical binding]; other site 243160005037 dimer interface [polypeptide binding]; other site 243160005038 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 243160005039 active site 243160005040 dimer interfaces [polypeptide binding]; other site 243160005041 catalytic residues [active] 243160005042 short chain dehydrogenase; Provisional; Region: PRK08339 243160005043 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 243160005044 putative NAD(P) binding site [chemical binding]; other site 243160005045 putative active site [active] 243160005046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160005047 active site 243160005048 hypothetical protein; Validated; Region: PRK00110 243160005049 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243160005050 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243160005051 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 243160005052 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243160005053 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 243160005054 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 243160005055 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 243160005056 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243160005057 active site 243160005058 (T/H)XGH motif; other site 243160005059 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 243160005060 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 243160005061 Maf-like protein; Region: Maf; pfam02545 243160005062 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243160005063 active site 243160005064 dimer interface [polypeptide binding]; other site 243160005065 ribonuclease G; Provisional; Region: PRK11712 243160005066 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243160005067 homodimer interface [polypeptide binding]; other site 243160005068 oligonucleotide binding site [chemical binding]; other site 243160005069 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 243160005070 Pectinacetylesterase; Region: PAE; pfam03283 243160005071 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 243160005072 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 243160005073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160005074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160005075 DNA binding residues [nucleotide binding] 243160005076 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243160005077 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243160005078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160005079 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 243160005080 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 243160005081 putative metal binding site; other site 243160005082 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160005083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160005084 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160005085 putative active site [active] 243160005086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160005087 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243160005088 putative ADP-binding pocket [chemical binding]; other site 243160005089 O-Antigen ligase; Region: Wzy_C; cl04850 243160005090 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160005091 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160005092 putative active site [active] 243160005093 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 243160005094 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243160005095 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 243160005096 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160005097 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243160005098 Walker A/P-loop; other site 243160005099 ATP binding site [chemical binding]; other site 243160005100 Q-loop/lid; other site 243160005101 ABC transporter signature motif; other site 243160005102 Walker B; other site 243160005103 D-loop; other site 243160005104 H-loop/switch region; other site 243160005105 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243160005106 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 243160005107 putative active site [active] 243160005108 putative PHP Thumb interface [polypeptide binding]; other site 243160005109 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243160005110 generic binding surface II; other site 243160005111 generic binding surface I; other site 243160005112 rhodanese superfamily protein; Provisional; Region: PRK05320 243160005113 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 243160005114 active site residue [active] 243160005115 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 243160005116 active site 243160005117 HIGH motif; other site 243160005118 nucleotide binding site [chemical binding]; other site 243160005119 KMSKS motif; other site 243160005120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243160005121 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243160005122 ATP binding site [chemical binding]; other site 243160005123 Mg++ binding site [ion binding]; other site 243160005124 motif III; other site 243160005125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160005126 nucleotide binding region [chemical binding]; other site 243160005127 ATP-binding site [chemical binding]; other site 243160005128 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 243160005129 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 243160005130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160005131 ATP-grasp domain; Region: ATP-grasp; pfam02222 243160005132 META domain; Region: META; pfam03724 243160005133 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243160005134 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243160005135 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 243160005136 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 243160005137 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 243160005138 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 243160005139 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 243160005140 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 243160005141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160005142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160005143 ferredoxin; Provisional; Region: PRK06991 243160005144 Putative Fe-S cluster; Region: FeS; pfam04060 243160005145 4Fe-4S binding domain; Region: Fer4; pfam00037 243160005146 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243160005147 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243160005148 minor groove reading motif; other site 243160005149 helix-hairpin-helix signature motif; other site 243160005150 substrate binding pocket [chemical binding]; other site 243160005151 active site 243160005152 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 243160005153 EamA-like transporter family; Region: EamA; pfam00892 243160005154 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 243160005155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160005156 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160005157 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243160005158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160005159 Walker A motif; other site 243160005160 ATP binding site [chemical binding]; other site 243160005161 Walker B motif; other site 243160005162 arginine finger; other site 243160005163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 243160005164 Benzoate membrane transport protein; Region: BenE; pfam03594 243160005165 benzoate transporter; Region: benE; TIGR00843 243160005166 transaldolase-like protein; Provisional; Region: PTZ00411 243160005167 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 243160005168 active site 243160005169 dimer interface [polypeptide binding]; other site 243160005170 catalytic residue [active] 243160005171 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243160005172 dimer interface [polypeptide binding]; other site 243160005173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160005174 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 243160005175 Na binding site [ion binding]; other site 243160005176 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 243160005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160005178 Chorismate lyase; Region: Chor_lyase; cl01230 243160005179 heat shock protein 90; Provisional; Region: PRK05218 243160005180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160005181 ATP binding site [chemical binding]; other site 243160005182 Mg2+ binding site [ion binding]; other site 243160005183 G-X-G motif; other site 243160005184 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160005185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160005186 DNA-binding site [nucleotide binding]; DNA binding site 243160005187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160005188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005189 homodimer interface [polypeptide binding]; other site 243160005190 catalytic residue [active] 243160005191 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 243160005192 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160005193 EamA-like transporter family; Region: EamA; pfam00892 243160005194 EamA-like transporter family; Region: EamA; pfam00892 243160005195 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 243160005196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160005197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005198 homodimer interface [polypeptide binding]; other site 243160005199 catalytic residue [active] 243160005200 Transposase; Region: HTH_Tnp_1; pfam01527 243160005201 HTH-like domain; Region: HTH_21; pfam13276 243160005202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005203 Integrase core domain; Region: rve; pfam00665 243160005204 Integrase core domain; Region: rve_3; pfam13683 243160005205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243160005206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160005207 non-specific DNA binding site [nucleotide binding]; other site 243160005208 salt bridge; other site 243160005209 sequence-specific DNA binding site [nucleotide binding]; other site 243160005210 Cupin domain; Region: Cupin_2; pfam07883 243160005211 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 243160005212 intersubunit interface [polypeptide binding]; other site 243160005213 active site 243160005214 Zn2+ binding site [ion binding]; other site 243160005215 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 243160005216 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243160005217 inhibitor site; inhibition site 243160005218 active site 243160005219 dimer interface [polypeptide binding]; other site 243160005220 catalytic residue [active] 243160005221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 243160005222 MOSC domain; Region: MOSC; pfam03473 243160005223 3-alpha domain; Region: 3-alpha; pfam03475 243160005224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160005225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160005226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160005227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160005228 dimerization interface [polypeptide binding]; other site 243160005229 CopC domain; Region: CopC; pfam04234 243160005230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160005231 RNA binding surface [nucleotide binding]; other site 243160005232 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243160005233 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 243160005234 active site 243160005235 uracil binding [chemical binding]; other site 243160005236 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160005237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160005238 NAD(P) binding site [chemical binding]; other site 243160005239 active site 243160005240 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 243160005241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160005242 catalytic loop [active] 243160005243 iron binding site [ion binding]; other site 243160005244 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 243160005245 FAD binding pocket [chemical binding]; other site 243160005246 FAD binding motif [chemical binding]; other site 243160005247 phosphate binding motif [ion binding]; other site 243160005248 beta-alpha-beta structure motif; other site 243160005249 NAD binding pocket [chemical binding]; other site 243160005250 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 243160005251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160005252 inhibitor-cofactor binding pocket; inhibition site 243160005253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005254 catalytic residue [active] 243160005255 putative acetyltransferase; Provisional; Region: PRK03624 243160005256 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243160005257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243160005258 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243160005259 Walker A/P-loop; other site 243160005260 ATP binding site [chemical binding]; other site 243160005261 Q-loop/lid; other site 243160005262 ABC transporter signature motif; other site 243160005263 Walker B; other site 243160005264 D-loop; other site 243160005265 H-loop/switch region; other site 243160005266 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 243160005267 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243160005268 TM-ABC transporter signature motif; other site 243160005269 Transposase; Region: HTH_Tnp_1; pfam01527 243160005270 HTH-like domain; Region: HTH_21; pfam13276 243160005271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005272 Integrase core domain; Region: rve; pfam00665 243160005273 Integrase core domain; Region: rve_3; pfam13683 243160005274 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 243160005275 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 243160005276 NAD(P) binding site [chemical binding]; other site 243160005277 homodimer interface [polypeptide binding]; other site 243160005278 substrate binding site [chemical binding]; other site 243160005279 active site 243160005280 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 243160005281 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 243160005282 Mg++ binding site [ion binding]; other site 243160005283 putative catalytic motif [active] 243160005284 putative substrate binding site [chemical binding]; other site 243160005285 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160005286 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 243160005287 putative NAD(P) binding site [chemical binding]; other site 243160005288 active site 243160005289 putative substrate binding site [chemical binding]; other site 243160005290 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243160005291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160005292 active site 243160005293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160005294 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243160005295 Methyltransferase domain; Region: Methyltransf_12; pfam08242 243160005296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243160005297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243160005298 active site 243160005299 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243160005300 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243160005301 Probable Catalytic site; other site 243160005302 metal-binding site 243160005303 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160005304 extended (e) SDRs; Region: SDR_e; cd08946 243160005305 NAD(P) binding site [chemical binding]; other site 243160005306 active site 243160005307 substrate binding site [chemical binding]; other site 243160005308 Acyltransferase family; Region: Acyl_transf_3; pfam01757 243160005309 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243160005310 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243160005311 Walker A/P-loop; other site 243160005312 ATP binding site [chemical binding]; other site 243160005313 Q-loop/lid; other site 243160005314 ABC transporter signature motif; other site 243160005315 Walker B; other site 243160005316 D-loop; other site 243160005317 H-loop/switch region; other site 243160005318 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 243160005319 putative carbohydrate binding site [chemical binding]; other site 243160005320 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243160005321 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243160005322 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243160005323 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 243160005324 NADP binding site [chemical binding]; other site 243160005325 active site 243160005326 putative substrate binding site [chemical binding]; other site 243160005327 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 243160005328 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 243160005329 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 243160005330 substrate binding site; other site 243160005331 tetramer interface; other site 243160005332 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243160005333 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243160005334 NAD binding site [chemical binding]; other site 243160005335 substrate binding site [chemical binding]; other site 243160005336 homodimer interface [polypeptide binding]; other site 243160005337 active site 243160005338 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 243160005339 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 243160005340 active site 243160005341 metal binding site [ion binding]; metal-binding site 243160005342 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243160005343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243160005344 putative acyl-acceptor binding pocket; other site 243160005345 dihydroorotase; Provisional; Region: PRK07627 243160005346 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160005347 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243160005348 active site 243160005349 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243160005350 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243160005351 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243160005352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160005353 active site 243160005354 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 243160005355 hypothetical protein; Validated; Region: PRK00228 243160005356 Rubredoxin [Energy production and conversion]; Region: COG1773 243160005357 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243160005358 iron binding site [ion binding]; other site 243160005359 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243160005360 dimer interface [polypeptide binding]; other site 243160005361 substrate binding site [chemical binding]; other site 243160005362 ATP binding site [chemical binding]; other site 243160005363 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243160005364 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243160005365 ring oligomerisation interface [polypeptide binding]; other site 243160005366 ATP/Mg binding site [chemical binding]; other site 243160005367 stacking interactions; other site 243160005368 hinge regions; other site 243160005369 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243160005370 oligomerisation interface [polypeptide binding]; other site 243160005371 mobile loop; other site 243160005372 roof hairpin; other site 243160005373 Predicted transcriptional regulators [Transcription]; Region: COG1733 243160005374 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243160005375 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 243160005376 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243160005377 putative NAD(P) binding site [chemical binding]; other site 243160005378 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 243160005379 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 243160005380 Predicted transcriptional regulators [Transcription]; Region: COG1733 243160005381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160005382 dimerization interface [polypeptide binding]; other site 243160005383 putative DNA binding site [nucleotide binding]; other site 243160005384 putative Zn2+ binding site [ion binding]; other site 243160005385 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243160005386 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243160005387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160005388 non-specific DNA binding site [nucleotide binding]; other site 243160005389 salt bridge; other site 243160005390 sequence-specific DNA binding site [nucleotide binding]; other site 243160005391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160005392 Coenzyme A binding pocket [chemical binding]; other site 243160005393 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160005394 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243160005395 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 243160005396 putative active site [active] 243160005397 catalytic site [active] 243160005398 putative metal binding site [ion binding]; other site 243160005399 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160005400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005401 putative substrate translocation pore; other site 243160005402 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243160005403 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 243160005404 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 243160005405 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 243160005406 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 243160005407 BON domain; Region: BON; pfam04972 243160005408 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 243160005409 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 243160005410 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 243160005411 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 243160005412 putative catalytic residue [active] 243160005413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160005414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160005415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160005416 dimerization interface [polypeptide binding]; other site 243160005417 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 243160005418 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243160005419 dimer interface [polypeptide binding]; other site 243160005420 putative PBP binding regions; other site 243160005421 ABC-ATPase subunit interface; other site 243160005422 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 243160005423 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 243160005424 Walker A/P-loop; other site 243160005425 ATP binding site [chemical binding]; other site 243160005426 Q-loop/lid; other site 243160005427 ABC transporter signature motif; other site 243160005428 Walker B; other site 243160005429 D-loop; other site 243160005430 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 243160005431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160005432 N-terminal plug; other site 243160005433 ligand-binding site [chemical binding]; other site 243160005434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 243160005435 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 243160005436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 243160005437 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243160005438 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 243160005439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160005440 catalytic loop [active] 243160005441 iron binding site [ion binding]; other site 243160005442 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 243160005443 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 243160005444 major facilitator superfamily transporter; Provisional; Region: PRK05122 243160005445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005446 putative substrate translocation pore; other site 243160005447 EamA-like transporter family; Region: EamA; pfam00892 243160005448 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243160005449 EamA-like transporter family; Region: EamA; pfam00892 243160005450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160005451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160005452 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 243160005453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160005454 catalytic residue [active] 243160005455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160005456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160005457 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160005458 putative effector binding pocket; other site 243160005459 dimerization interface [polypeptide binding]; other site 243160005460 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243160005461 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 243160005462 putative ligand binding site [chemical binding]; other site 243160005463 putative NAD binding site [chemical binding]; other site 243160005464 catalytic site [active] 243160005465 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 243160005466 putative FMN binding site [chemical binding]; other site 243160005467 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243160005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005469 putative substrate translocation pore; other site 243160005470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160005472 putative substrate translocation pore; other site 243160005473 fumarylacetoacetase; Region: PLN02856 243160005474 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 243160005475 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243160005476 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 243160005477 benzoate transport; Region: 2A0115; TIGR00895 243160005478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005479 putative substrate translocation pore; other site 243160005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005481 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 243160005482 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 243160005483 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243160005484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243160005485 EAL domain; Region: EAL; pfam00563 243160005486 Uncharacterized conserved protein [Function unknown]; Region: COG3791 243160005487 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160005488 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160005489 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160005490 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 243160005491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160005492 FAD binding site [chemical binding]; other site 243160005493 substrate binding pocket [chemical binding]; other site 243160005494 catalytic base [active] 243160005495 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243160005496 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 243160005497 dimer interface [polypeptide binding]; other site 243160005498 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243160005499 catalytic triad [active] 243160005500 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 243160005501 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 243160005502 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 243160005503 Type II transport protein GspH; Region: GspH; pfam12019 243160005504 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243160005505 ATP cone domain; Region: ATP-cone; pfam03477 243160005506 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 243160005507 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243160005508 dimer interface [polypeptide binding]; other site 243160005509 active site 243160005510 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243160005511 folate binding site [chemical binding]; other site 243160005512 malonic semialdehyde reductase; Provisional; Region: PRK10538 243160005513 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 243160005514 putative NAD(P) binding site [chemical binding]; other site 243160005515 homodimer interface [polypeptide binding]; other site 243160005516 homotetramer interface [polypeptide binding]; other site 243160005517 active site 243160005518 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243160005519 active site 243160005520 TolQ protein; Region: tolQ; TIGR02796 243160005521 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243160005522 TolR protein; Region: tolR; TIGR02801 243160005523 TolA protein; Region: tolA_full; TIGR02794 243160005524 TonB C terminal; Region: TonB_2; pfam13103 243160005525 translocation protein TolB; Provisional; Region: tolB; PRK02889 243160005526 TolB amino-terminal domain; Region: TolB_N; pfam04052 243160005527 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243160005528 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243160005529 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243160005530 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243160005531 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160005532 ligand binding site [chemical binding]; other site 243160005533 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243160005534 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243160005535 Transposase; Region: HTH_Tnp_1; pfam01527 243160005536 HTH-like domain; Region: HTH_21; pfam13276 243160005537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005538 Integrase core domain; Region: rve; pfam00665 243160005539 Integrase core domain; Region: rve_3; pfam13683 243160005540 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160005541 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160005542 trimer interface [polypeptide binding]; other site 243160005543 eyelet of channel; other site 243160005544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160005545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160005546 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 243160005547 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243160005548 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243160005549 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 243160005550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243160005551 Zn2+ binding site [ion binding]; other site 243160005552 Mg2+ binding site [ion binding]; other site 243160005553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243160005554 synthetase active site [active] 243160005555 NTP binding site [chemical binding]; other site 243160005556 metal binding site [ion binding]; metal-binding site 243160005557 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243160005558 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243160005559 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 243160005560 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 243160005561 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243160005562 catalytic site [active] 243160005563 G-X2-G-X-G-K; other site 243160005564 hypothetical protein; Provisional; Region: PRK11820 243160005565 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 243160005566 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 243160005567 ribonuclease PH; Reviewed; Region: rph; PRK00173 243160005568 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243160005569 hexamer interface [polypeptide binding]; other site 243160005570 active site 243160005571 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243160005572 active site 243160005573 dimerization interface [polypeptide binding]; other site 243160005574 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 243160005575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160005576 FeS/SAM binding site; other site 243160005577 HemN C-terminal domain; Region: HemN_C; pfam06969 243160005578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243160005579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005580 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160005581 putative substrate translocation pore; other site 243160005582 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160005583 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160005584 putative active site [active] 243160005585 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243160005586 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 243160005587 putative ion selectivity filter; other site 243160005588 putative pore gating glutamate residue; other site 243160005589 putative H+/Cl- coupling transport residue; other site 243160005590 cell division topological specificity factor MinE; Provisional; Region: PRK13989 243160005591 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 243160005592 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 243160005593 Switch I; other site 243160005594 Switch II; other site 243160005595 septum formation inhibitor; Reviewed; Region: PRK01973 243160005596 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 243160005597 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 243160005598 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243160005599 seryl-tRNA synthetase; Provisional; Region: PRK05431 243160005600 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243160005601 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243160005602 dimer interface [polypeptide binding]; other site 243160005603 active site 243160005604 motif 1; other site 243160005605 motif 2; other site 243160005606 motif 3; other site 243160005607 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 243160005608 recombination factor protein RarA; Reviewed; Region: PRK13342 243160005609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160005610 Walker A motif; other site 243160005611 ATP binding site [chemical binding]; other site 243160005612 Walker B motif; other site 243160005613 arginine finger; other site 243160005614 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243160005615 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 243160005616 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 243160005617 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243160005618 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243160005619 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 243160005620 thioredoxin reductase; Provisional; Region: PRK10262 243160005621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160005622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 243160005623 Smr domain; Region: Smr; pfam01713 243160005624 Predicted membrane protein [Function unknown]; Region: COG2860 243160005625 UPF0126 domain; Region: UPF0126; pfam03458 243160005626 UPF0126 domain; Region: UPF0126; pfam03458 243160005627 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243160005628 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 243160005629 Walker A/P-loop; other site 243160005630 ATP binding site [chemical binding]; other site 243160005631 Q-loop/lid; other site 243160005632 ABC transporter signature motif; other site 243160005633 Walker B; other site 243160005634 D-loop; other site 243160005635 H-loop/switch region; other site 243160005636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243160005637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160005638 dimer interface [polypeptide binding]; other site 243160005639 conserved gate region; other site 243160005640 putative PBP binding loops; other site 243160005641 ABC-ATPase subunit interface; other site 243160005642 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243160005643 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243160005644 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243160005645 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243160005646 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243160005647 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 243160005648 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243160005649 putative active site [active] 243160005650 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 243160005651 glucokinase; Provisional; Region: glk; PRK00292 243160005652 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160005653 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160005654 putative active site [active] 243160005655 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160005656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160005657 substrate binding pocket [chemical binding]; other site 243160005658 membrane-bound complex binding site; other site 243160005659 hinge residues; other site 243160005660 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160005662 dimer interface [polypeptide binding]; other site 243160005663 conserved gate region; other site 243160005664 putative PBP binding loops; other site 243160005665 ABC-ATPase subunit interface; other site 243160005666 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243160005667 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160005668 Walker A/P-loop; other site 243160005669 ATP binding site [chemical binding]; other site 243160005670 Q-loop/lid; other site 243160005671 ABC transporter signature motif; other site 243160005672 Walker B; other site 243160005673 D-loop; other site 243160005674 H-loop/switch region; other site 243160005675 D-cysteine desulfhydrase; Validated; Region: PRK03910 243160005676 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 243160005677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160005678 catalytic residue [active] 243160005679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160005680 putative substrate translocation pore; other site 243160005681 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243160005682 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160005683 inhibitor-cofactor binding pocket; inhibition site 243160005684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005685 catalytic residue [active] 243160005686 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 243160005687 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243160005688 catalytic motif [active] 243160005689 Zn binding site [ion binding]; other site 243160005690 RibD C-terminal domain; Region: RibD_C; cl17279 243160005691 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243160005692 Lumazine binding domain; Region: Lum_binding; pfam00677 243160005693 Lumazine binding domain; Region: Lum_binding; pfam00677 243160005694 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 243160005695 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243160005696 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 243160005697 dimerization interface [polypeptide binding]; other site 243160005698 active site 243160005699 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243160005700 homopentamer interface [polypeptide binding]; other site 243160005701 active site 243160005702 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 243160005703 putative RNA binding site [nucleotide binding]; other site 243160005704 aminotransferase; Validated; Region: PRK07337 243160005705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160005706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005707 homodimer interface [polypeptide binding]; other site 243160005708 catalytic residue [active] 243160005709 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243160005710 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160005711 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160005712 catalytic residue [active] 243160005713 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 243160005714 LysE type translocator; Region: LysE; cl00565 243160005715 serine racemase; Region: PLN02970 243160005716 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243160005717 tetramer interface [polypeptide binding]; other site 243160005718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005719 catalytic residue [active] 243160005720 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 243160005721 Rossmann-like domain; Region: Rossmann-like; pfam10727 243160005722 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 243160005723 YGGT family; Region: YGGT; pfam02325 243160005724 YGGT family; Region: YGGT; pfam02325 243160005725 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243160005726 chromosome condensation membrane protein; Provisional; Region: PRK14196 243160005727 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 243160005728 active site 243160005729 catalytic triad [active] 243160005730 calcium binding site [ion binding]; other site 243160005731 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160005732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160005733 S-adenosylmethionine binding site [chemical binding]; other site 243160005734 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 243160005735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160005736 S-adenosylmethionine binding site [chemical binding]; other site 243160005737 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 243160005738 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 243160005739 Flagellin N-methylase; Region: FliB; pfam03692 243160005740 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 243160005741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160005742 FeS/SAM binding site; other site 243160005743 HemN C-terminal domain; Region: HemN_C; pfam06969 243160005744 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 243160005745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160005746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160005747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243160005748 active site residue [active] 243160005749 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 243160005750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160005751 inhibitor-cofactor binding pocket; inhibition site 243160005752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160005753 catalytic residue [active] 243160005754 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243160005755 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 243160005756 putative ligand binding site [chemical binding]; other site 243160005757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243160005758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160005759 TM-ABC transporter signature motif; other site 243160005760 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 243160005761 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243160005762 TM-ABC transporter signature motif; other site 243160005763 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 243160005764 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243160005765 Walker A/P-loop; other site 243160005766 ATP binding site [chemical binding]; other site 243160005767 Q-loop/lid; other site 243160005768 ABC transporter signature motif; other site 243160005769 Walker B; other site 243160005770 D-loop; other site 243160005771 H-loop/switch region; other site 243160005772 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 243160005773 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243160005774 Walker A/P-loop; other site 243160005775 ATP binding site [chemical binding]; other site 243160005776 Q-loop/lid; other site 243160005777 ABC transporter signature motif; other site 243160005778 Walker B; other site 243160005779 D-loop; other site 243160005780 H-loop/switch region; other site 243160005781 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 243160005782 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 243160005783 alpha-gamma subunit interface [polypeptide binding]; other site 243160005784 beta-gamma subunit interface [polypeptide binding]; other site 243160005785 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 243160005786 gamma-beta subunit interface [polypeptide binding]; other site 243160005787 alpha-beta subunit interface [polypeptide binding]; other site 243160005788 urease subunit alpha; Reviewed; Region: ureC; PRK13207 243160005789 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 243160005790 subunit interactions [polypeptide binding]; other site 243160005791 active site 243160005792 flap region; other site 243160005793 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 243160005794 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 243160005795 dimer interface [polypeptide binding]; other site 243160005796 catalytic residues [active] 243160005797 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 243160005798 UreF; Region: UreF; pfam01730 243160005799 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243160005800 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 243160005801 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 243160005802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160005803 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 243160005804 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160005805 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160005806 putative active site [active] 243160005807 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243160005808 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 243160005809 active site 243160005810 substrate binding site [chemical binding]; other site 243160005811 metal binding site [ion binding]; metal-binding site 243160005812 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243160005813 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243160005814 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243160005815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160005816 active site 243160005817 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 243160005818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160005819 putative ADP-binding pocket [chemical binding]; other site 243160005820 UDP-glucose 4-epimerase; Region: PLN02240 243160005821 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243160005822 NAD binding site [chemical binding]; other site 243160005823 homodimer interface [polypeptide binding]; other site 243160005824 active site 243160005825 substrate binding site [chemical binding]; other site 243160005826 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 243160005827 Mg++ binding site [ion binding]; other site 243160005828 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 243160005829 putative catalytic motif [active] 243160005830 Transposase; Region: HTH_Tnp_1; pfam01527 243160005831 HTH-like domain; Region: HTH_21; pfam13276 243160005832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005833 Integrase core domain; Region: rve; pfam00665 243160005834 Integrase core domain; Region: rve_3; pfam13683 243160005835 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243160005836 rRNA binding site [nucleotide binding]; other site 243160005837 predicted 30S ribosome binding site; other site 243160005838 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160005839 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160005840 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 243160005841 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243160005842 Rubredoxin; Region: Rubredoxin; pfam00301 243160005843 iron binding site [ion binding]; other site 243160005844 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 243160005845 ABC transporter ATPase component; Reviewed; Region: PRK11147 243160005846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160005847 Walker A/P-loop; other site 243160005848 ATP binding site [chemical binding]; other site 243160005849 Q-loop/lid; other site 243160005850 ABC transporter signature motif; other site 243160005851 Walker B; other site 243160005852 D-loop; other site 243160005853 H-loop/switch region; other site 243160005854 ABC transporter; Region: ABC_tran_2; pfam12848 243160005855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160005856 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 243160005857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160005858 ATP binding site [chemical binding]; other site 243160005859 Mg2+ binding site [ion binding]; other site 243160005860 G-X-G motif; other site 243160005861 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243160005862 anchoring element; other site 243160005863 dimer interface [polypeptide binding]; other site 243160005864 ATP binding site [chemical binding]; other site 243160005865 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 243160005866 active site 243160005867 metal binding site [ion binding]; metal-binding site 243160005868 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243160005869 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 243160005870 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243160005871 CAP-like domain; other site 243160005872 active site 243160005873 primary dimer interface [polypeptide binding]; other site 243160005874 Copper resistance protein D; Region: CopD; pfam05425 243160005875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160005876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160005877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160005878 dimerization interface [polypeptide binding]; other site 243160005879 Predicted membrane protein [Function unknown]; Region: COG4125 243160005880 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 243160005881 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 243160005882 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160005883 allantoate amidohydrolase; Reviewed; Region: PRK12893 243160005884 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 243160005885 active site 243160005886 metal binding site [ion binding]; metal-binding site 243160005887 dimer interface [polypeptide binding]; other site 243160005888 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243160005889 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 243160005890 active site 243160005891 Zn binding site [ion binding]; other site 243160005892 Chromate transporter; Region: Chromate_transp; pfam02417 243160005893 Chromate transporter; Region: Chromate_transp; pfam02417 243160005894 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160005895 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160005896 metal binding site [ion binding]; metal-binding site 243160005897 active site 243160005898 I-site; other site 243160005899 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160005900 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 243160005901 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 243160005902 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 243160005903 homotrimer interaction site [polypeptide binding]; other site 243160005904 putative active site [active] 243160005905 Transposase; Region: HTH_Tnp_1; pfam01527 243160005906 HTH-like domain; Region: HTH_21; pfam13276 243160005907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005908 Integrase core domain; Region: rve; pfam00665 243160005909 Integrase core domain; Region: rve_3; pfam13683 243160005910 Transposase domain (DUF772); Region: DUF772; pfam05598 243160005911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160005912 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160005913 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 243160005914 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 243160005915 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243160005916 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243160005917 hypothetical protein; Reviewed; Region: PRK00024 243160005918 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243160005919 MPN+ (JAMM) motif; other site 243160005920 Zinc-binding site [ion binding]; other site 243160005921 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243160005922 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 243160005923 L-aspartate oxidase; Provisional; Region: PRK09077 243160005924 L-aspartate oxidase; Provisional; Region: PRK06175 243160005925 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243160005926 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 243160005927 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243160005928 dimerization interface [polypeptide binding]; other site 243160005929 active site 243160005930 quinolinate synthetase; Provisional; Region: PRK09375 243160005931 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243160005932 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243160005933 Di-iron ligands [ion binding]; other site 243160005934 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160005935 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243160005936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243160005937 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 243160005938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160005939 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 243160005940 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 243160005941 active site 243160005942 substrate binding site [chemical binding]; other site 243160005943 cosubstrate binding site; other site 243160005944 catalytic site [active] 243160005945 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243160005946 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243160005947 active site 243160005948 Riboflavin kinase; Region: Flavokinase; smart00904 243160005949 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243160005950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160005951 active site 243160005952 HIGH motif; other site 243160005953 nucleotide binding site [chemical binding]; other site 243160005954 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243160005955 active site 243160005956 KMSKS motif; other site 243160005957 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243160005958 tRNA binding surface [nucleotide binding]; other site 243160005959 anticodon binding site; other site 243160005960 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243160005961 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 243160005962 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 243160005963 Flavoprotein; Region: Flavoprotein; pfam02441 243160005964 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 243160005965 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243160005966 trimer interface [polypeptide binding]; other site 243160005967 active site 243160005968 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 243160005969 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160005970 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160005971 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160005972 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160005973 HTH-like domain; Region: HTH_21; pfam13276 243160005974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160005975 Integrase core domain; Region: rve; pfam00665 243160005976 Integrase core domain; Region: rve_3; pfam13683 243160005977 Transposase; Region: HTH_Tnp_1; pfam01527 243160005978 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 243160005979 elongation factor G; Reviewed; Region: PRK00007 243160005980 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243160005981 G1 box; other site 243160005982 putative GEF interaction site [polypeptide binding]; other site 243160005983 GTP/Mg2+ binding site [chemical binding]; other site 243160005984 Switch I region; other site 243160005985 G2 box; other site 243160005986 G3 box; other site 243160005987 Switch II region; other site 243160005988 G4 box; other site 243160005989 G5 box; other site 243160005990 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243160005991 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243160005992 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243160005993 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243160005994 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243160005995 active site 243160005996 catalytic tetrad [active] 243160005997 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243160005998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160005999 DNA-binding site [nucleotide binding]; DNA binding site 243160006000 UTRA domain; Region: UTRA; pfam07702 243160006001 Helix-turn-helix domain; Region: HTH_17; pfam12728 243160006002 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 243160006003 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 243160006004 dimer interface [polypeptide binding]; other site 243160006005 active site 243160006006 oxalacetate/citrate binding site [chemical binding]; other site 243160006007 citrylCoA binding site [chemical binding]; other site 243160006008 coenzyme A binding site [chemical binding]; other site 243160006009 catalytic triad [active] 243160006010 putative transporter; Provisional; Region: PRK10504 243160006011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160006012 putative substrate translocation pore; other site 243160006013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160006014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160006015 S-adenosylmethionine binding site [chemical binding]; other site 243160006016 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 243160006017 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243160006018 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243160006019 Protein of unknown function (DUF962); Region: DUF962; cl01879 243160006020 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243160006021 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160006022 ligand binding site [chemical binding]; other site 243160006023 flexible hinge region; other site 243160006024 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243160006025 putative switch regulator; other site 243160006026 non-specific DNA interactions [nucleotide binding]; other site 243160006027 DNA binding site [nucleotide binding] 243160006028 sequence specific DNA binding site [nucleotide binding]; other site 243160006029 putative cAMP binding site [chemical binding]; other site 243160006030 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 243160006031 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 243160006032 Chromate transporter; Region: Chromate_transp; pfam02417 243160006033 HTH-like domain; Region: HTH_21; pfam13276 243160006034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160006035 Integrase core domain; Region: rve; pfam00665 243160006036 Integrase core domain; Region: rve_3; pfam13683 243160006037 Transposase; Region: HTH_Tnp_1; pfam01527 243160006038 superoxide dismutase; Provisional; Region: PRK10543 243160006039 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 243160006040 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243160006041 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 243160006042 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243160006043 generic binding surface II; other site 243160006044 generic binding surface I; other site 243160006045 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 243160006046 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 243160006047 Uncharacterized conserved protein [Function unknown]; Region: COG2835 243160006048 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 243160006049 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 243160006050 Ligand binding site; other site 243160006051 oligomer interface; other site 243160006052 adenylate kinase; Reviewed; Region: adk; PRK00279 243160006053 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243160006054 AMP-binding site [chemical binding]; other site 243160006055 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243160006056 Transposase domain (DUF772); Region: DUF772; pfam05598 243160006057 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160006058 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160006059 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243160006060 DNA-binding site [nucleotide binding]; DNA binding site 243160006061 RNA-binding motif; other site 243160006062 Uncharacterized conserved protein [Function unknown]; Region: COG2127 243160006063 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 243160006064 Clp amino terminal domain; Region: Clp_N; pfam02861 243160006065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160006066 Walker A motif; other site 243160006067 ATP binding site [chemical binding]; other site 243160006068 Walker B motif; other site 243160006069 arginine finger; other site 243160006070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160006071 Walker A motif; other site 243160006072 ATP binding site [chemical binding]; other site 243160006073 Walker B motif; other site 243160006074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243160006075 HTH-like domain; Region: HTH_21; pfam13276 243160006076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160006077 Integrase core domain; Region: rve; pfam00665 243160006078 Integrase core domain; Region: rve_3; pfam13683 243160006079 Transposase; Region: HTH_Tnp_1; pfam01527 243160006080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160006081 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243160006082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160006083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160006084 catalytic residue [active] 243160006085 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 243160006086 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243160006087 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243160006088 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160006089 active site 243160006090 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243160006091 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243160006092 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243160006093 Methyltransferase domain; Region: Methyltransf_12; pfam08242 243160006094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160006095 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243160006096 Enoylreductase; Region: PKS_ER; smart00829 243160006097 NAD(P) binding site [chemical binding]; other site 243160006098 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243160006099 KR domain; Region: KR; pfam08659 243160006100 putative NADP binding site [chemical binding]; other site 243160006101 active site 243160006102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160006103 Sulfatase; Region: Sulfatase; pfam00884 243160006104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160006105 NAD(P) binding site [chemical binding]; other site 243160006106 active site 243160006107 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 243160006108 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 243160006109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160006110 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 243160006111 active site 243160006112 motif I; other site 243160006113 motif II; other site 243160006114 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243160006115 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 243160006116 Substrate binding site; other site 243160006117 Mg++ binding site; other site 243160006118 metal-binding site 243160006119 Mg++ binding site; other site 243160006120 metal-binding site 243160006121 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160006122 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243160006123 dimer interface [polypeptide binding]; other site 243160006124 active site 243160006125 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 243160006126 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243160006127 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243160006128 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243160006129 NADP-binding site; other site 243160006130 homotetramer interface [polypeptide binding]; other site 243160006131 substrate binding site [chemical binding]; other site 243160006132 homodimer interface [polypeptide binding]; other site 243160006133 active site 243160006134 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 243160006135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160006136 NAD(P) binding site [chemical binding]; other site 243160006137 active site 243160006138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160006139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160006140 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 243160006141 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243160006142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160006143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243160006144 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243160006145 Walker A/P-loop; other site 243160006146 ATP binding site [chemical binding]; other site 243160006147 Q-loop/lid; other site 243160006148 ABC transporter signature motif; other site 243160006149 Walker B; other site 243160006150 D-loop; other site 243160006151 H-loop/switch region; other site 243160006152 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243160006153 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243160006154 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 243160006155 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243160006156 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243160006157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160006158 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 243160006159 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243160006160 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243160006161 Substrate binding site; other site 243160006162 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243160006163 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 243160006164 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243160006165 putative active site [active] 243160006166 putative dimer interface [polypeptide binding]; other site 243160006167 mechanosensitive channel MscS; Provisional; Region: PRK10334 243160006168 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243160006169 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243160006170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243160006171 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 243160006172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160006173 ATP binding site [chemical binding]; other site 243160006174 Mg2+ binding site [ion binding]; other site 243160006175 G-X-G motif; other site 243160006176 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 243160006177 ATP binding site [chemical binding]; other site 243160006178 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 243160006179 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243160006180 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 243160006181 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 243160006182 SnoaL-like domain; Region: SnoaL_3; pfam13474 243160006183 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243160006184 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243160006185 dimerization interface [polypeptide binding]; other site 243160006186 putative ATP binding site [chemical binding]; other site 243160006187 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 243160006188 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 243160006189 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243160006190 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243160006191 poly(A) polymerase; Region: pcnB; TIGR01942 243160006192 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243160006193 active site 243160006194 NTP binding site [chemical binding]; other site 243160006195 metal binding triad [ion binding]; metal-binding site 243160006196 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243160006197 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 243160006198 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243160006199 catalytic center binding site [active] 243160006200 ATP binding site [chemical binding]; other site 243160006201 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 243160006202 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 243160006203 Substrate-binding site [chemical binding]; other site 243160006204 Substrate specificity [chemical binding]; other site 243160006205 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243160006206 oligomerization interface [polypeptide binding]; other site 243160006207 active site 243160006208 metal binding site [ion binding]; metal-binding site 243160006209 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 243160006210 chorismate binding enzyme; Region: Chorismate_bind; cl10555 243160006211 hypothetical protein; Provisional; Region: PRK07546 243160006212 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243160006213 homodimer interface [polypeptide binding]; other site 243160006214 substrate-cofactor binding pocket; other site 243160006215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160006216 catalytic residue [active] 243160006217 chaperone protein DnaJ; Provisional; Region: PRK10767 243160006218 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243160006219 HSP70 interaction site [polypeptide binding]; other site 243160006220 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243160006221 Zn binding sites [ion binding]; other site 243160006222 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243160006223 dimer interface [polypeptide binding]; other site 243160006224 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243160006225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243160006226 nucleotide binding site [chemical binding]; other site 243160006227 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243160006228 GrpE; Region: GrpE; pfam01025 243160006229 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243160006230 dimer interface [polypeptide binding]; other site 243160006231 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243160006232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160006233 RNA binding surface [nucleotide binding]; other site 243160006234 ferrochelatase; Reviewed; Region: hemH; PRK00035 243160006235 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243160006236 C-terminal domain interface [polypeptide binding]; other site 243160006237 active site 243160006238 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243160006239 active site 243160006240 N-terminal domain interface [polypeptide binding]; other site 243160006241 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 243160006242 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 243160006243 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 243160006244 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 243160006245 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 243160006246 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243160006247 Walker A/P-loop; other site 243160006248 ATP binding site [chemical binding]; other site 243160006249 Q-loop/lid; other site 243160006250 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243160006251 ABC transporter signature motif; other site 243160006252 Walker B; other site 243160006253 D-loop; other site 243160006254 H-loop/switch region; other site 243160006255 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 243160006256 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243160006257 metal binding triad; other site 243160006258 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243160006259 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243160006260 metal binding triad; other site 243160006261 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243160006262 TIGR02099 family protein; Region: TIGR02099 243160006263 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243160006264 nitrilase; Region: PLN02798 243160006265 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 243160006266 putative active site [active] 243160006267 catalytic triad [active] 243160006268 dimer interface [polypeptide binding]; other site 243160006269 protease TldD; Provisional; Region: tldD; PRK10735 243160006270 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 243160006271 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243160006272 Transposase domain (DUF772); Region: DUF772; pfam05598 243160006273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160006274 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160006275 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243160006276 23S rRNA interface [nucleotide binding]; other site 243160006277 L3 interface [polypeptide binding]; other site 243160006278 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243160006279 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 243160006280 Cupin; Region: Cupin_6; pfam12852 243160006281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160006282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160006283 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 243160006284 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 243160006285 C-terminal domain interface [polypeptide binding]; other site 243160006286 GSH binding site (G-site) [chemical binding]; other site 243160006287 dimer interface [polypeptide binding]; other site 243160006288 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243160006289 N-terminal domain interface [polypeptide binding]; other site 243160006290 dimer interface [polypeptide binding]; other site 243160006291 substrate binding pocket (H-site) [chemical binding]; other site 243160006292 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 243160006293 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243160006294 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243160006295 active site 243160006296 HIGH motif; other site 243160006297 dimer interface [polypeptide binding]; other site 243160006298 KMSKS motif; other site 243160006299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160006300 RNA binding surface [nucleotide binding]; other site 243160006301 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 243160006302 putative active site [active] 243160006303 dimerization interface [polypeptide binding]; other site 243160006304 putative tRNAtyr binding site [nucleotide binding]; other site 243160006305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160006306 catalytic core [active] 243160006307 Putative ParB-like nuclease; Region: ParBc_2; cl17538 243160006308 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 243160006309 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243160006310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160006311 Walker A motif; other site 243160006312 ATP binding site [chemical binding]; other site 243160006313 Walker B motif; other site 243160006314 arginine finger; other site 243160006315 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243160006316 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243160006317 RuvA N terminal domain; Region: RuvA_N; pfam01330 243160006318 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 243160006319 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 243160006320 active site 243160006321 putative DNA-binding cleft [nucleotide binding]; other site 243160006322 dimer interface [polypeptide binding]; other site 243160006323 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243160006324 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243160006325 purine monophosphate binding site [chemical binding]; other site 243160006326 dimer interface [polypeptide binding]; other site 243160006327 putative catalytic residues [active] 243160006328 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243160006329 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 243160006330 DNA-binding protein Fis; Provisional; Region: PRK01905 243160006331 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 243160006332 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243160006333 FMN binding site [chemical binding]; other site 243160006334 active site 243160006335 catalytic residues [active] 243160006336 substrate binding site [chemical binding]; other site 243160006337 hypothetical protein; Provisional; Region: PRK06996 243160006338 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243160006339 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 243160006340 proline aminopeptidase P II; Provisional; Region: PRK10879 243160006341 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 243160006342 active site 243160006343 putative glutathione S-transferase; Provisional; Region: PRK10357 243160006344 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 243160006345 putative C-terminal domain interface [polypeptide binding]; other site 243160006346 putative GSH binding site (G-site) [chemical binding]; other site 243160006347 putative dimer interface [polypeptide binding]; other site 243160006348 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 243160006349 dimer interface [polypeptide binding]; other site 243160006350 N-terminal domain interface [polypeptide binding]; other site 243160006351 putative substrate binding pocket (H-site) [chemical binding]; other site 243160006352 Transposase domain (DUF772); Region: DUF772; pfam05598 243160006353 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160006354 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160006355 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 243160006356 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243160006357 active site 243160006358 FMN binding site [chemical binding]; other site 243160006359 substrate binding site [chemical binding]; other site 243160006360 3Fe-4S cluster binding site [ion binding]; other site 243160006361 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 243160006362 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243160006363 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 243160006364 nudix motif; other site 243160006365 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 243160006366 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 243160006367 ligand binding site [chemical binding]; other site 243160006368 homodimer interface [polypeptide binding]; other site 243160006369 NAD(P) binding site [chemical binding]; other site 243160006370 trimer interface B [polypeptide binding]; other site 243160006371 trimer interface A [polypeptide binding]; other site 243160006372 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 243160006373 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 243160006374 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 243160006375 Predicted transcriptional regulator [Transcription]; Region: COG2378 243160006376 HTH domain; Region: HTH_11; pfam08279 243160006377 WYL domain; Region: WYL; pfam13280 243160006378 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 243160006379 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 243160006380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160006381 Site-specific recombinase; Region: SpecificRecomb; pfam10136 243160006382 Protein of unknown function (DUF330); Region: DUF330; pfam03886 243160006383 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 243160006384 mce related protein; Region: MCE; pfam02470 243160006385 mce related protein; Region: MCE; pfam02470 243160006386 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 243160006387 YceI-like domain; Region: YceI; smart00867 243160006388 Uncharacterized conserved protein [Function unknown]; Region: COG2353 243160006389 citrate-proton symporter; Provisional; Region: PRK15075 243160006390 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 243160006391 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243160006392 Protein export membrane protein; Region: SecD_SecF; pfam02355 243160006393 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 243160006394 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243160006395 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243160006396 Protein export membrane protein; Region: SecD_SecF; cl14618 243160006397 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 243160006398 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243160006399 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243160006400 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 243160006401 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 243160006402 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 243160006403 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243160006404 generic binding surface II; other site 243160006405 ssDNA binding site; other site 243160006406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160006407 ATP binding site [chemical binding]; other site 243160006408 putative Mg++ binding site [ion binding]; other site 243160006409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160006410 nucleotide binding region [chemical binding]; other site 243160006411 ATP-binding site [chemical binding]; other site 243160006412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160006413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160006414 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 243160006415 dimerization interface [polypeptide binding]; other site 243160006416 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 243160006417 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 243160006418 dimer interface [polypeptide binding]; other site 243160006419 active site 243160006420 heme binding site [chemical binding]; other site 243160006421 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 243160006422 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 243160006423 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 243160006424 dimerization interface [polypeptide binding]; other site 243160006425 DPS ferroxidase diiron center [ion binding]; other site 243160006426 ion pore; other site 243160006427 Predicted transcriptional regulators [Transcription]; Region: COG1733 243160006428 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243160006429 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 243160006430 UbiA prenyltransferase family; Region: UbiA; pfam01040 243160006431 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243160006432 active site 243160006433 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 243160006434 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 243160006435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160006436 DNA-binding site [nucleotide binding]; DNA binding site 243160006437 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 243160006438 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 243160006439 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 243160006440 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 243160006441 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 243160006442 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 243160006443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160006444 Walker A/P-loop; other site 243160006445 ATP binding site [chemical binding]; other site 243160006446 Q-loop/lid; other site 243160006447 ABC transporter signature motif; other site 243160006448 Walker B; other site 243160006449 D-loop; other site 243160006450 H-loop/switch region; other site 243160006451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160006452 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 243160006453 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160006454 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 243160006455 active site 243160006456 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 243160006457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160006458 Walker A/P-loop; other site 243160006459 ATP binding site [chemical binding]; other site 243160006460 Q-loop/lid; other site 243160006461 ABC transporter signature motif; other site 243160006462 Walker B; other site 243160006463 D-loop; other site 243160006464 H-loop/switch region; other site 243160006465 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 243160006466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160006467 dimer interface [polypeptide binding]; other site 243160006468 conserved gate region; other site 243160006469 ABC-ATPase subunit interface; other site 243160006470 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 243160006471 pyrroline-5-carboxylate reductase; Region: PLN02688 243160006472 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 243160006473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160006474 catalytic residue [active] 243160006475 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 243160006476 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243160006477 Cysteine-rich domain; Region: CCG; pfam02754 243160006478 Cysteine-rich domain; Region: CCG; pfam02754 243160006479 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 243160006480 FAD binding domain; Region: FAD_binding_4; pfam01565 243160006481 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 243160006482 FAD binding domain; Region: FAD_binding_4; pfam01565 243160006483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160006484 FAD binding domain; Region: FAD_binding_4; pfam01565 243160006485 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 243160006486 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 243160006487 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 243160006488 heme-binding site [chemical binding]; other site 243160006489 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 243160006490 FAD binding pocket [chemical binding]; other site 243160006491 FAD binding motif [chemical binding]; other site 243160006492 phosphate binding motif [ion binding]; other site 243160006493 beta-alpha-beta structure motif; other site 243160006494 NAD binding pocket [chemical binding]; other site 243160006495 Heme binding pocket [chemical binding]; other site 243160006496 Transposase domain (DUF772); Region: DUF772; pfam05598 243160006497 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160006498 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160006499 OsmC-like protein; Region: OsmC; cl00767 243160006500 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 243160006501 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 243160006502 active site 243160006503 substrate binding pocket [chemical binding]; other site 243160006504 dimer interface [polypeptide binding]; other site 243160006505 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243160006506 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 243160006507 putative active site [active] 243160006508 putative dimer interface [polypeptide binding]; other site 243160006509 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243160006510 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243160006511 putative dimer interface [polypeptide binding]; other site 243160006512 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243160006513 oligomerisation interface [polypeptide binding]; other site 243160006514 mobile loop; other site 243160006515 roof hairpin; other site 243160006516 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243160006517 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160006518 Walker A/P-loop; other site 243160006519 ATP binding site [chemical binding]; other site 243160006520 Q-loop/lid; other site 243160006521 ABC transporter signature motif; other site 243160006522 Walker B; other site 243160006523 D-loop; other site 243160006524 H-loop/switch region; other site 243160006525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160006526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160006527 dimer interface [polypeptide binding]; other site 243160006528 conserved gate region; other site 243160006529 putative PBP binding loops; other site 243160006530 ABC-ATPase subunit interface; other site 243160006531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160006532 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160006533 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 243160006534 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 243160006535 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 243160006536 NAD(P) binding site [chemical binding]; other site 243160006537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160006538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160006539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160006540 dimerization interface [polypeptide binding]; other site 243160006541 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243160006542 adenylosuccinate lyase; Provisional; Region: PRK09285 243160006543 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 243160006544 tetramer interface [polypeptide binding]; other site 243160006545 active site 243160006546 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 243160006547 ATP-binding site [chemical binding]; other site 243160006548 Gluconate-6-phosphate binding site [chemical binding]; other site 243160006549 Shikimate kinase; Region: SKI; pfam01202 243160006550 GntP family permease; Region: GntP_permease; pfam02447 243160006551 fructuronate transporter; Provisional; Region: PRK10034; cl15264 243160006552 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 243160006553 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 243160006554 active site 243160006555 intersubunit interface [polypeptide binding]; other site 243160006556 catalytic residue [active] 243160006557 phosphogluconate dehydratase; Validated; Region: PRK09054 243160006558 6-phosphogluconate dehydratase; Region: edd; TIGR01196 243160006559 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160006560 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160006561 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160006562 putative active site [active] 243160006563 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 243160006564 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243160006565 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 243160006566 putative catalytic cysteine [active] 243160006567 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 243160006568 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 243160006569 Lipopolysaccharide-assembly; Region: LptE; cl01125 243160006570 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243160006571 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243160006572 HIGH motif; other site 243160006573 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243160006574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160006575 active site 243160006576 KMSKS motif; other site 243160006577 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243160006578 tRNA binding surface [nucleotide binding]; other site 243160006579 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243160006580 TolR protein; Region: tolR; TIGR02801 243160006581 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243160006582 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243160006583 dihydrodipicolinate reductase; Provisional; Region: PRK00048 243160006584 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243160006585 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243160006586 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 243160006587 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 243160006588 ferric uptake regulator; Provisional; Region: fur; PRK09462 243160006589 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243160006590 metal binding site 2 [ion binding]; metal-binding site 243160006591 putative DNA binding helix; other site 243160006592 metal binding site 1 [ion binding]; metal-binding site 243160006593 dimer interface [polypeptide binding]; other site 243160006594 structural Zn2+ binding site [ion binding]; other site 243160006595 allantoicase; Provisional; Region: PRK13257 243160006596 Allantoicase repeat; Region: Allantoicase; pfam03561 243160006597 Allantoicase repeat; Region: Allantoicase; pfam03561 243160006598 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 243160006599 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 243160006600 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243160006601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160006602 DNA-binding site [nucleotide binding]; DNA binding site 243160006603 FCD domain; Region: FCD; pfam07729 243160006604 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 243160006605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160006606 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 243160006607 dimerization interface [polypeptide binding]; other site 243160006608 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 243160006609 active site clefts [active] 243160006610 zinc binding site [ion binding]; other site 243160006611 dimer interface [polypeptide binding]; other site 243160006612 cyanate hydratase; Validated; Region: PRK02866 243160006613 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 243160006614 oligomer interface [polypeptide binding]; other site 243160006615 active site 243160006616 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243160006617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160006618 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243160006619 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 243160006620 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243160006621 transketolase; Reviewed; Region: PRK12753 243160006622 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243160006623 TPP-binding site [chemical binding]; other site 243160006624 dimer interface [polypeptide binding]; other site 243160006625 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243160006626 PYR/PP interface [polypeptide binding]; other site 243160006627 dimer interface [polypeptide binding]; other site 243160006628 TPP binding site [chemical binding]; other site 243160006629 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243160006630 spermidine synthase; Provisional; Region: PRK00811 243160006631 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 243160006632 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 243160006633 putative dimer interface [polypeptide binding]; other site 243160006634 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160006635 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 243160006636 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 243160006637 putative RNAase interaction site [polypeptide binding]; other site 243160006638 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 243160006639 active site 243160006640 barstar interaction site; other site 243160006641 malic enzyme; Reviewed; Region: PRK12862 243160006642 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243160006643 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 243160006644 putative NAD(P) binding site [chemical binding]; other site 243160006645 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 243160006646 thiamine monophosphate kinase; Provisional; Region: PRK05731 243160006647 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243160006648 ATP binding site [chemical binding]; other site 243160006649 dimerization interface [polypeptide binding]; other site 243160006650 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 243160006651 tetramer interfaces [polypeptide binding]; other site 243160006652 binuclear metal-binding site [ion binding]; other site 243160006653 Competence-damaged protein; Region: CinA; pfam02464 243160006654 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243160006655 active site 243160006656 dimer interface [polypeptide binding]; other site 243160006657 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 243160006658 active site 243160006659 catalytic residues [active] 243160006660 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243160006661 classical (c) SDRs; Region: SDR_c; cd05233 243160006662 NAD(P) binding site [chemical binding]; other site 243160006663 active site 243160006664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160006665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160006666 TM-ABC transporter signature motif; other site 243160006667 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 243160006668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243160006669 Walker A/P-loop; other site 243160006670 ATP binding site [chemical binding]; other site 243160006671 Q-loop/lid; other site 243160006672 ABC transporter signature motif; other site 243160006673 Walker B; other site 243160006674 D-loop; other site 243160006675 H-loop/switch region; other site 243160006676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243160006677 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 243160006678 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 243160006679 ligand binding site [chemical binding]; other site 243160006680 short chain dehydrogenase; Provisional; Region: PRK07063 243160006681 classical (c) SDRs; Region: SDR_c; cd05233 243160006682 NAD(P) binding site [chemical binding]; other site 243160006683 active site 243160006684 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 243160006685 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 243160006686 active site 243160006687 intersubunit interface [polypeptide binding]; other site 243160006688 catalytic residue [active] 243160006689 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 243160006690 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 243160006691 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160006692 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160006693 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160006694 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 243160006695 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 243160006696 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 243160006697 Transglycosylase; Region: Transgly; cl17702 243160006698 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 243160006699 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243160006700 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243160006701 shikimate binding site; other site 243160006702 NAD(P) binding site [chemical binding]; other site 243160006703 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 243160006704 RNB domain; Region: RNB; pfam00773 243160006705 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 243160006706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160006707 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 243160006708 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243160006709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160006710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160006711 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243160006712 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160006713 catalytic residues [active] 243160006714 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243160006715 Dehydroquinase class II; Region: DHquinase_II; pfam01220 243160006716 active site 243160006717 trimer interface [polypeptide binding]; other site 243160006718 dimer interface [polypeptide binding]; other site 243160006719 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 243160006720 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243160006721 carboxyltransferase (CT) interaction site; other site 243160006722 biotinylation site [posttranslational modification]; other site 243160006723 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243160006724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243160006725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243160006726 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243160006727 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 243160006728 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243160006729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160006730 S-adenosylmethionine binding site [chemical binding]; other site 243160006731 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 243160006732 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 243160006733 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 243160006734 dimer interface [polypeptide binding]; other site 243160006735 catalytic triad [active] 243160006736 peroxidatic and resolving cysteines [active] 243160006737 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 243160006738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160006739 substrate binding site [chemical binding]; other site 243160006740 ATP binding site [chemical binding]; other site 243160006741 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 243160006742 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 243160006743 dimer interface [polypeptide binding]; other site 243160006744 putative radical transfer pathway; other site 243160006745 diiron center [ion binding]; other site 243160006746 tyrosyl radical; other site 243160006747 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 243160006748 ATP cone domain; Region: ATP-cone; pfam03477 243160006749 Class I ribonucleotide reductase; Region: RNR_I; cd01679 243160006750 active site 243160006751 dimer interface [polypeptide binding]; other site 243160006752 catalytic residues [active] 243160006753 effector binding site; other site 243160006754 R2 peptide binding site; other site 243160006755 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243160006756 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243160006757 amidase catalytic site [active] 243160006758 Zn binding residues [ion binding]; other site 243160006759 substrate binding site [chemical binding]; other site 243160006760 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243160006761 signal recognition particle protein; Provisional; Region: PRK10867 243160006762 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243160006763 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243160006764 P loop; other site 243160006765 GTP binding site [chemical binding]; other site 243160006766 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243160006767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160006768 active site 243160006769 MarC family integral membrane protein; Region: MarC; cl00919 243160006770 prolyl-tRNA synthetase; Provisional; Region: PRK09194 243160006771 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 243160006772 dimer interface [polypeptide binding]; other site 243160006773 motif 1; other site 243160006774 active site 243160006775 motif 2; other site 243160006776 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 243160006777 putative deacylase active site [active] 243160006778 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243160006779 active site 243160006780 motif 3; other site 243160006781 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 243160006782 anticodon binding site; other site 243160006783 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 243160006784 putative active site [active] 243160006785 Ap4A binding site [chemical binding]; other site 243160006786 nudix motif; other site 243160006787 putative metal binding site [ion binding]; other site 243160006788 CNP1-like family; Region: CNP1; pfam08750 243160006789 gamma-glutamyl kinase; Provisional; Region: PRK05429 243160006790 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243160006791 nucleotide binding site [chemical binding]; other site 243160006792 homotetrameric interface [polypeptide binding]; other site 243160006793 putative phosphate binding site [ion binding]; other site 243160006794 putative allosteric binding site; other site 243160006795 PUA domain; Region: PUA; pfam01472 243160006796 GTPase CgtA; Reviewed; Region: obgE; PRK12298 243160006797 GTP1/OBG; Region: GTP1_OBG; pfam01018 243160006798 Obg GTPase; Region: Obg; cd01898 243160006799 G1 box; other site 243160006800 GTP/Mg2+ binding site [chemical binding]; other site 243160006801 Switch I region; other site 243160006802 G2 box; other site 243160006803 G3 box; other site 243160006804 Switch II region; other site 243160006805 G4 box; other site 243160006806 G5 box; other site 243160006807 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243160006808 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 243160006809 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243160006810 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243160006811 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243160006812 substrate binding pocket [chemical binding]; other site 243160006813 chain length determination region; other site 243160006814 substrate-Mg2+ binding site; other site 243160006815 catalytic residues [active] 243160006816 aspartate-rich region 1; other site 243160006817 active site lid residues [active] 243160006818 aspartate-rich region 2; other site 243160006819 HTH-like domain; Region: HTH_21; pfam13276 243160006820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160006821 Integrase core domain; Region: rve; pfam00665 243160006822 Integrase core domain; Region: rve_3; pfam13683 243160006823 Transposase; Region: HTH_Tnp_1; pfam01527 243160006824 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 243160006825 Domain of unknown function DUF21; Region: DUF21; pfam01595 243160006826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243160006827 Transporter associated domain; Region: CorC_HlyC; smart01091 243160006828 Type II/IV secretion system protein; Region: T2SE; pfam00437 243160006829 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243160006830 Walker A motif; other site 243160006831 ATP binding site [chemical binding]; other site 243160006832 Walker B motif; other site 243160006833 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243160006834 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160006835 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160006836 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243160006837 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 243160006838 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243160006839 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 243160006840 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243160006841 CoA-binding site [chemical binding]; other site 243160006842 ATP-binding [chemical binding]; other site 243160006843 hypothetical protein; Provisional; Region: PRK05287 243160006844 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 243160006845 active site 243160006846 8-oxo-dGMP binding site [chemical binding]; other site 243160006847 nudix motif; other site 243160006848 metal binding site [ion binding]; metal-binding site 243160006849 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 243160006850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160006851 Walker A motif; other site 243160006852 ATP binding site [chemical binding]; other site 243160006853 Walker B motif; other site 243160006854 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243160006855 heterotetramer interface [polypeptide binding]; other site 243160006856 active site pocket [active] 243160006857 cleavage site 243160006858 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 243160006859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243160006860 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243160006861 SEC-C motif; Region: SEC-C; pfam02810 243160006862 Protein of unknown function (DUF721); Region: DUF721; pfam05258 243160006863 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 243160006864 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243160006865 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 243160006866 catalytic triad [active] 243160006867 dimer interface [polypeptide binding]; other site 243160006868 cell division protein FtsZ; Validated; Region: PRK09330 243160006869 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243160006870 nucleotide binding site [chemical binding]; other site 243160006871 SulA interaction site; other site 243160006872 cell division protein FtsA; Region: ftsA; TIGR01174 243160006873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243160006874 nucleotide binding site [chemical binding]; other site 243160006875 Cell division protein FtsA; Region: FtsA; pfam14450 243160006876 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 243160006877 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 243160006878 Cell division protein FtsQ; Region: FtsQ; pfam03799 243160006879 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 243160006880 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 243160006881 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243160006882 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 243160006883 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243160006884 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160006885 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160006886 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 243160006887 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 243160006888 active site 243160006889 homodimer interface [polypeptide binding]; other site 243160006890 cell division protein FtsW; Region: ftsW; TIGR02614 243160006891 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 243160006892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160006893 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160006894 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 243160006895 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 243160006896 Mg++ binding site [ion binding]; other site 243160006897 putative catalytic motif [active] 243160006898 putative substrate binding site [chemical binding]; other site 243160006899 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 243160006900 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243160006901 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160006902 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160006903 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 243160006904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160006905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160006906 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243160006907 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243160006908 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243160006909 Cell division protein FtsL; Region: FtsL; pfam04999 243160006910 MraW methylase family; Region: Methyltransf_5; cl17771 243160006911 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 243160006912 cell division protein MraZ; Reviewed; Region: PRK00326 243160006913 MraZ protein; Region: MraZ; pfam02381 243160006914 MraZ protein; Region: MraZ; pfam02381 243160006915 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 243160006916 diiron binding motif [ion binding]; other site 243160006917 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160006918 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160006919 trimer interface [polypeptide binding]; other site 243160006920 eyelet of channel; other site 243160006921 Transposase domain (DUF772); Region: DUF772; pfam05598 243160006922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160006923 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160006924 HTH-like domain; Region: HTH_21; pfam13276 243160006925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160006926 Integrase core domain; Region: rve; pfam00665 243160006927 Integrase core domain; Region: rve_3; pfam13683 243160006928 Transposase; Region: HTH_Tnp_1; pfam01527 243160006929 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 243160006930 active site 243160006931 catalytic triad [active] 243160006932 oxyanion hole [active] 243160006933 transcription termination factor Rho; Provisional; Region: PRK12678 243160006934 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 243160006935 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 243160006936 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 243160006937 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 243160006938 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 243160006939 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 243160006940 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 243160006941 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 243160006942 FAD binding pocket [chemical binding]; other site 243160006943 FAD binding motif [chemical binding]; other site 243160006944 phosphate binding motif [ion binding]; other site 243160006945 beta-alpha-beta structure motif; other site 243160006946 NAD(p) ribose binding residues [chemical binding]; other site 243160006947 NAD binding pocket [chemical binding]; other site 243160006948 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 243160006949 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160006950 catalytic loop [active] 243160006951 iron binding site [ion binding]; other site 243160006952 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 243160006953 Protein of unknown function; Region: DUF3658; pfam12395 243160006954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160006955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160006956 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 243160006957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160006958 Coenzyme A binding pocket [chemical binding]; other site 243160006959 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160006960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160006961 putative DNA binding site [nucleotide binding]; other site 243160006962 putative Zn2+ binding site [ion binding]; other site 243160006963 AsnC family; Region: AsnC_trans_reg; pfam01037 243160006964 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 243160006965 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 243160006966 dimer interface [polypeptide binding]; other site 243160006967 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 243160006968 active site 243160006969 Fe binding site [ion binding]; other site 243160006970 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 243160006971 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243160006972 dimer interface [polypeptide binding]; other site 243160006973 PYR/PP interface [polypeptide binding]; other site 243160006974 TPP binding site [chemical binding]; other site 243160006975 substrate binding site [chemical binding]; other site 243160006976 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 243160006977 TPP-binding site; other site 243160006978 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 243160006979 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 243160006980 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243160006981 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 243160006982 putative NAD(P) binding site [chemical binding]; other site 243160006983 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 243160006984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160006985 active site 243160006986 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243160006987 substrate binding site [chemical binding]; other site 243160006988 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243160006989 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160006990 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 243160006991 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243160006992 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 243160006993 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 243160006994 HTH-like domain; Region: HTH_21; pfam13276 243160006995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160006996 Integrase core domain; Region: rve; pfam00665 243160006997 Integrase core domain; Region: rve_3; pfam13683 243160006998 Transposase; Region: HTH_Tnp_1; pfam01527 243160006999 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 243160007000 Cytochrome c553 [Energy production and conversion]; Region: COG2863 243160007001 Cytochrome c; Region: Cytochrom_C; cl11414 243160007002 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 243160007003 G1 box; other site 243160007004 GTP/Mg2+ binding site [chemical binding]; other site 243160007005 Switch I region; other site 243160007006 G2 box; other site 243160007007 G3 box; other site 243160007008 Switch II region; other site 243160007009 G4 box; other site 243160007010 G5 box; other site 243160007011 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 243160007012 dimer interface [polypeptide binding]; other site 243160007013 active site 243160007014 aspartate-rich active site metal binding site; other site 243160007015 allosteric magnesium binding site [ion binding]; other site 243160007016 Schiff base residues; other site 243160007017 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 243160007018 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 243160007019 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 243160007020 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 243160007021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160007022 DsbD alpha interface [polypeptide binding]; other site 243160007023 catalytic residues [active] 243160007024 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 243160007025 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 243160007026 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243160007027 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243160007028 alphaNTD homodimer interface [polypeptide binding]; other site 243160007029 alphaNTD - beta interaction site [polypeptide binding]; other site 243160007030 alphaNTD - beta' interaction site [polypeptide binding]; other site 243160007031 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243160007032 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243160007033 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243160007034 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243160007035 RNA binding surface [nucleotide binding]; other site 243160007036 30S ribosomal protein S11; Validated; Region: PRK05309 243160007037 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243160007038 30S ribosomal protein S13; Region: bact_S13; TIGR03631 243160007039 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 243160007040 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243160007041 rRNA binding site [nucleotide binding]; other site 243160007042 predicted 30S ribosome binding site; other site 243160007043 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243160007044 SecY translocase; Region: SecY; pfam00344 243160007045 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243160007046 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 243160007047 23S rRNA binding site [nucleotide binding]; other site 243160007048 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243160007049 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243160007050 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243160007051 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243160007052 5S rRNA interface [nucleotide binding]; other site 243160007053 L27 interface [polypeptide binding]; other site 243160007054 23S rRNA interface [nucleotide binding]; other site 243160007055 L5 interface [polypeptide binding]; other site 243160007056 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243160007057 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243160007058 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243160007059 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243160007060 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 243160007061 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243160007062 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243160007063 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243160007064 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 243160007065 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243160007066 RNA binding site [nucleotide binding]; other site 243160007067 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243160007068 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243160007069 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243160007070 23S rRNA interface [nucleotide binding]; other site 243160007071 putative translocon interaction site; other site 243160007072 signal recognition particle (SRP54) interaction site; other site 243160007073 L23 interface [polypeptide binding]; other site 243160007074 trigger factor interaction site; other site 243160007075 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243160007076 23S rRNA interface [nucleotide binding]; other site 243160007077 5S rRNA interface [nucleotide binding]; other site 243160007078 putative antibiotic binding site [chemical binding]; other site 243160007079 L25 interface [polypeptide binding]; other site 243160007080 L27 interface [polypeptide binding]; other site 243160007081 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 243160007082 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243160007083 G-X-X-G motif; other site 243160007084 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243160007085 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243160007086 putative translocon binding site; other site 243160007087 protein-rRNA interface [nucleotide binding]; other site 243160007088 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243160007089 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243160007090 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243160007091 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243160007092 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243160007093 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 243160007094 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 243160007095 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243160007096 elongation factor Tu; Reviewed; Region: PRK00049 243160007097 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243160007098 G1 box; other site 243160007099 GEF interaction site [polypeptide binding]; other site 243160007100 GTP/Mg2+ binding site [chemical binding]; other site 243160007101 Switch I region; other site 243160007102 G2 box; other site 243160007103 G3 box; other site 243160007104 Switch II region; other site 243160007105 G4 box; other site 243160007106 G5 box; other site 243160007107 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243160007108 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243160007109 Antibiotic Binding Site [chemical binding]; other site 243160007110 elongation factor G; Reviewed; Region: PRK00007 243160007111 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243160007112 G1 box; other site 243160007113 putative GEF interaction site [polypeptide binding]; other site 243160007114 GTP/Mg2+ binding site [chemical binding]; other site 243160007115 Switch I region; other site 243160007116 G2 box; other site 243160007117 G3 box; other site 243160007118 Switch II region; other site 243160007119 G4 box; other site 243160007120 G5 box; other site 243160007121 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243160007122 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243160007123 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243160007124 30S ribosomal protein S7; Validated; Region: PRK05302 243160007125 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243160007126 S17 interaction site [polypeptide binding]; other site 243160007127 S8 interaction site; other site 243160007128 16S rRNA interaction site [nucleotide binding]; other site 243160007129 streptomycin interaction site [chemical binding]; other site 243160007130 23S rRNA interaction site [nucleotide binding]; other site 243160007131 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243160007132 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 243160007133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160007134 ATP binding site [chemical binding]; other site 243160007135 putative Mg++ binding site [ion binding]; other site 243160007136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160007137 nucleotide binding region [chemical binding]; other site 243160007138 ATP-binding site [chemical binding]; other site 243160007139 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 243160007140 HRDC domain; Region: HRDC; pfam00570 243160007141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160007142 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160007143 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 243160007144 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 243160007145 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 243160007146 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 243160007147 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 243160007148 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 243160007149 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 243160007150 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243160007151 DNA binding site [nucleotide binding] 243160007152 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243160007153 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243160007154 peripheral dimer interface [polypeptide binding]; other site 243160007155 core dimer interface [polypeptide binding]; other site 243160007156 L10 interface [polypeptide binding]; other site 243160007157 L11 interface [polypeptide binding]; other site 243160007158 putative EF-Tu interaction site [polypeptide binding]; other site 243160007159 putative EF-G interaction site [polypeptide binding]; other site 243160007160 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243160007161 23S rRNA interface [nucleotide binding]; other site 243160007162 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243160007163 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243160007164 mRNA/rRNA interface [nucleotide binding]; other site 243160007165 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243160007166 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243160007167 23S rRNA interface [nucleotide binding]; other site 243160007168 L7/L12 interface [polypeptide binding]; other site 243160007169 putative thiostrepton binding site; other site 243160007170 L25 interface [polypeptide binding]; other site 243160007171 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243160007172 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243160007173 putative homodimer interface [polypeptide binding]; other site 243160007174 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243160007175 heterodimer interface [polypeptide binding]; other site 243160007176 homodimer interface [polypeptide binding]; other site 243160007177 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 243160007178 elongation factor Tu; Reviewed; Region: PRK00049 243160007179 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243160007180 G1 box; other site 243160007181 GEF interaction site [polypeptide binding]; other site 243160007182 GTP/Mg2+ binding site [chemical binding]; other site 243160007183 Switch I region; other site 243160007184 G2 box; other site 243160007185 G3 box; other site 243160007186 Switch II region; other site 243160007187 G4 box; other site 243160007188 G5 box; other site 243160007189 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243160007190 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243160007191 Antibiotic Binding Site [chemical binding]; other site 243160007192 Transposase; Region: HTH_Tnp_1; pfam01527 243160007193 HTH-like domain; Region: HTH_21; pfam13276 243160007194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007195 Integrase core domain; Region: rve; pfam00665 243160007196 Integrase core domain; Region: rve_3; pfam13683 243160007197 Predicted membrane protein [Function unknown]; Region: COG4709 243160007198 Predicted transcriptional regulators [Transcription]; Region: COG1695 243160007199 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 243160007200 choline dehydrogenase; Validated; Region: PRK02106 243160007201 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243160007202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160007203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243160007204 classical (c) SDRs; Region: SDR_c; cd05233 243160007205 NAD(P) binding site [chemical binding]; other site 243160007206 active site 243160007207 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 243160007208 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160007209 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160007210 NAD(P) binding site [chemical binding]; other site 243160007211 catalytic residues [active] 243160007212 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243160007213 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 243160007214 putative ligand binding site [chemical binding]; other site 243160007215 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243160007216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160007217 TM-ABC transporter signature motif; other site 243160007218 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243160007219 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243160007220 Walker A/P-loop; other site 243160007221 ATP binding site [chemical binding]; other site 243160007222 Q-loop/lid; other site 243160007223 ABC transporter signature motif; other site 243160007224 Walker B; other site 243160007225 D-loop; other site 243160007226 H-loop/switch region; other site 243160007227 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243160007228 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243160007229 Walker A/P-loop; other site 243160007230 ATP binding site [chemical binding]; other site 243160007231 Q-loop/lid; other site 243160007232 ABC transporter signature motif; other site 243160007233 Walker B; other site 243160007234 D-loop; other site 243160007235 H-loop/switch region; other site 243160007236 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160007237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160007238 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160007239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160007240 trimer interface [polypeptide binding]; other site 243160007241 eyelet of channel; other site 243160007242 Restriction endonuclease [Defense mechanisms]; Region: COG3587 243160007243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160007244 ATP binding site [chemical binding]; other site 243160007245 putative Mg++ binding site [ion binding]; other site 243160007246 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 243160007247 DNA methylase; Region: N6_N4_Mtase; pfam01555 243160007248 DNA methylase; Region: N6_N4_Mtase; cl17433 243160007249 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160007250 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160007251 trimer interface [polypeptide binding]; other site 243160007252 eyelet of channel; other site 243160007253 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 243160007254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160007255 active site 243160007256 phosphorylation site [posttranslational modification] 243160007257 intermolecular recognition site; other site 243160007258 dimerization interface [polypeptide binding]; other site 243160007259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160007260 DNA binding site [nucleotide binding] 243160007261 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 243160007262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160007263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160007264 dimer interface [polypeptide binding]; other site 243160007265 phosphorylation site [posttranslational modification] 243160007266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160007267 ATP binding site [chemical binding]; other site 243160007268 Mg2+ binding site [ion binding]; other site 243160007269 G-X-G motif; other site 243160007270 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243160007271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160007272 dimer interface [polypeptide binding]; other site 243160007273 conserved gate region; other site 243160007274 putative PBP binding loops; other site 243160007275 ABC-ATPase subunit interface; other site 243160007276 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243160007277 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243160007278 Walker A/P-loop; other site 243160007279 ATP binding site [chemical binding]; other site 243160007280 Q-loop/lid; other site 243160007281 ABC transporter signature motif; other site 243160007282 Walker B; other site 243160007283 D-loop; other site 243160007284 H-loop/switch region; other site 243160007285 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243160007286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160007287 membrane-bound complex binding site; other site 243160007288 hinge residues; other site 243160007289 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 243160007290 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 243160007291 DNA binding residues [nucleotide binding] 243160007292 putative dimer interface [polypeptide binding]; other site 243160007293 putative metal binding residues [ion binding]; other site 243160007294 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 243160007295 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 243160007296 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 243160007297 HTH-like domain; Region: HTH_21; pfam13276 243160007298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007299 Integrase core domain; Region: rve; pfam00665 243160007300 Integrase core domain; Region: rve_3; pfam13683 243160007301 Transposase; Region: HTH_Tnp_1; pfam01527 243160007302 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 243160007303 portal vertex protein; Provisional; Region: Q; PHA02536 243160007304 Phage portal protein; Region: Phage_portal; pfam04860 243160007305 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 243160007306 stringent starvation protein A; Provisional; Region: sspA; PRK09481 243160007307 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 243160007308 C-terminal domain interface [polypeptide binding]; other site 243160007309 putative GSH binding site (G-site) [chemical binding]; other site 243160007310 dimer interface [polypeptide binding]; other site 243160007311 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 243160007312 dimer interface [polypeptide binding]; other site 243160007313 N-terminal domain interface [polypeptide binding]; other site 243160007314 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 243160007315 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243160007316 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 243160007317 Qi binding site; other site 243160007318 intrachain domain interface; other site 243160007319 interchain domain interface [polypeptide binding]; other site 243160007320 heme bH binding site [chemical binding]; other site 243160007321 heme bL binding site [chemical binding]; other site 243160007322 Qo binding site; other site 243160007323 interchain domain interface [polypeptide binding]; other site 243160007324 intrachain domain interface; other site 243160007325 Qi binding site; other site 243160007326 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 243160007327 Qo binding site; other site 243160007328 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 243160007329 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 243160007330 [2Fe-2S] cluster binding site [ion binding]; other site 243160007331 Uncharacterized conserved protein [Function unknown]; Region: COG0327 243160007332 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 243160007333 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243160007334 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243160007335 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160007336 protein binding site [polypeptide binding]; other site 243160007337 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 243160007338 sec-independent translocase; Provisional; Region: tatB; PRK01919 243160007339 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 243160007340 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 243160007341 nucleotide binding site/active site [active] 243160007342 HIT family signature motif; other site 243160007343 catalytic residue [active] 243160007344 Predicted membrane protein [Function unknown]; Region: COG3671 243160007345 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 243160007346 metal binding site [ion binding]; metal-binding site 243160007347 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243160007348 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243160007349 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243160007350 substrate binding site [chemical binding]; other site 243160007351 glutamase interaction surface [polypeptide binding]; other site 243160007352 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243160007353 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243160007354 catalytic residues [active] 243160007355 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 243160007356 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243160007357 putative active site [active] 243160007358 oxyanion strand; other site 243160007359 catalytic triad [active] 243160007360 MarC family integral membrane protein; Region: MarC; cl00919 243160007361 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243160007362 putative active site pocket [active] 243160007363 4-fold oligomerization interface [polypeptide binding]; other site 243160007364 metal binding residues [ion binding]; metal-binding site 243160007365 3-fold/trimer interface [polypeptide binding]; other site 243160007366 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 243160007367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160007369 homodimer interface [polypeptide binding]; other site 243160007370 catalytic residue [active] 243160007371 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 243160007372 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243160007373 NAD binding site [chemical binding]; other site 243160007374 dimerization interface [polypeptide binding]; other site 243160007375 product binding site; other site 243160007376 substrate binding site [chemical binding]; other site 243160007377 zinc binding site [ion binding]; other site 243160007378 catalytic residues [active] 243160007379 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 243160007380 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 243160007381 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 243160007382 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 243160007383 hinge; other site 243160007384 active site 243160007385 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 243160007386 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243160007387 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160007388 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243160007389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243160007390 Walker A/P-loop; other site 243160007391 ATP binding site [chemical binding]; other site 243160007392 Q-loop/lid; other site 243160007393 ABC transporter signature motif; other site 243160007394 Walker B; other site 243160007395 D-loop; other site 243160007396 H-loop/switch region; other site 243160007397 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243160007398 anti sigma factor interaction site; other site 243160007399 regulatory phosphorylation site [posttranslational modification]; other site 243160007400 VacJ like lipoprotein; Region: VacJ; cl01073 243160007401 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243160007402 mce related protein; Region: MCE; pfam02470 243160007403 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243160007404 Permease; Region: Permease; pfam02405 243160007405 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243160007406 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243160007407 Walker A/P-loop; other site 243160007408 ATP binding site [chemical binding]; other site 243160007409 Q-loop/lid; other site 243160007410 ABC transporter signature motif; other site 243160007411 Walker B; other site 243160007412 D-loop; other site 243160007413 H-loop/switch region; other site 243160007414 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243160007415 thiamine phosphate binding site [chemical binding]; other site 243160007416 active site 243160007417 pyrophosphate binding site [ion binding]; other site 243160007418 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243160007419 ThiS interaction site; other site 243160007420 putative active site [active] 243160007421 tetramer interface [polypeptide binding]; other site 243160007422 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243160007423 thiS-thiF/thiG interaction site; other site 243160007424 FAD dependent oxidoreductase; Region: DAO; pfam01266 243160007425 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 243160007426 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 243160007427 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 243160007428 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 243160007429 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 243160007430 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 243160007431 amino acid carrier protein; Region: agcS; TIGR00835 243160007432 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 243160007433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160007434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160007435 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243160007436 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 243160007437 active site 243160007438 dimer interface [polypeptide binding]; other site 243160007439 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243160007440 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243160007441 active site 243160007442 FMN binding site [chemical binding]; other site 243160007443 substrate binding site [chemical binding]; other site 243160007444 3Fe-4S cluster binding site [ion binding]; other site 243160007445 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 243160007446 domain interface; other site 243160007447 Transposase IS200 like; Region: Y1_Tnp; cl00848 243160007448 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 243160007449 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 243160007450 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 243160007451 active site 243160007452 catalytic site [active] 243160007453 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243160007454 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 243160007455 Walker A/P-loop; other site 243160007456 ATP binding site [chemical binding]; other site 243160007457 Q-loop/lid; other site 243160007458 ABC transporter signature motif; other site 243160007459 Walker B; other site 243160007460 D-loop; other site 243160007461 H-loop/switch region; other site 243160007462 TOBE domain; Region: TOBE_2; pfam08402 243160007463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243160007464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160007465 dimer interface [polypeptide binding]; other site 243160007466 conserved gate region; other site 243160007467 putative PBP binding loops; other site 243160007468 ABC-ATPase subunit interface; other site 243160007469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243160007470 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 243160007471 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 243160007472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243160007473 Zn2+ binding site [ion binding]; other site 243160007474 Mg2+ binding site [ion binding]; other site 243160007475 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 243160007476 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243160007477 active site 243160007478 dimer interface [polypeptide binding]; other site 243160007479 metal binding site [ion binding]; metal-binding site 243160007480 shikimate kinase; Reviewed; Region: aroK; PRK00131 243160007481 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243160007482 ADP binding site [chemical binding]; other site 243160007483 magnesium binding site [ion binding]; other site 243160007484 putative shikimate binding site; other site 243160007485 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243160007486 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160007487 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160007488 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 243160007489 Transglycosylase; Region: Transgly; pfam00912 243160007490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243160007491 Transposase domain (DUF772); Region: DUF772; pfam05598 243160007492 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160007493 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160007494 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 243160007495 putative iron binding site [ion binding]; other site 243160007496 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243160007497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243160007498 active site 243160007499 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160007500 substrate binding site [chemical binding]; other site 243160007501 catalytic residues [active] 243160007502 dimer interface [polypeptide binding]; other site 243160007503 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 243160007504 TMAO/DMSO reductase; Reviewed; Region: PRK05363 243160007505 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 243160007506 Moco binding site; other site 243160007507 metal coordination site [ion binding]; other site 243160007508 HTH-like domain; Region: HTH_21; pfam13276 243160007509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007510 Integrase core domain; Region: rve; pfam00665 243160007511 Integrase core domain; Region: rve_3; pfam13683 243160007512 Transposase; Region: HTH_Tnp_1; pfam01527 243160007513 FliP family; Region: FliP; cl00593 243160007514 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 243160007515 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 243160007516 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 243160007517 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243160007518 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 243160007519 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 243160007520 LrgB-like family; Region: LrgB; cl00596 243160007521 LrgA family; Region: LrgA; pfam03788 243160007522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160007523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160007524 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 243160007525 putative dimerization interface [polypeptide binding]; other site 243160007526 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160007527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160007528 putative substrate translocation pore; other site 243160007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160007530 MarR family; Region: MarR_2; cl17246 243160007531 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160007532 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160007533 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 243160007534 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 243160007535 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 243160007536 GspL periplasmic domain; Region: GspL_C; pfam12693 243160007537 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 243160007538 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 243160007539 type II secretion system protein I; Region: gspI; TIGR01707 243160007540 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 243160007541 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 243160007542 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243160007543 Type II transport protein GspH; Region: GspH; pfam12019 243160007544 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243160007545 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 243160007546 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243160007547 type II secretion system protein F; Region: GspF; TIGR02120 243160007548 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160007549 Ceramidase; Region: Ceramidase; pfam05875 243160007550 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160007551 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243160007552 type II secretion system protein E; Region: type_II_gspE; TIGR02533 243160007553 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243160007554 Walker A motif; other site 243160007555 ATP binding site [chemical binding]; other site 243160007556 Walker B motif; other site 243160007557 type II secretion system protein D; Region: type_II_gspD; TIGR02517 243160007558 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160007559 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160007560 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160007561 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 243160007562 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160007563 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243160007564 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160007565 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160007566 catalytic residue [active] 243160007567 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 243160007568 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 243160007569 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 243160007570 Transposase domain (DUF772); Region: DUF772; pfam05598 243160007571 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160007572 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160007573 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243160007574 DNA-binding site [nucleotide binding]; DNA binding site 243160007575 RNA-binding motif; other site 243160007576 Transposase; Region: HTH_Tnp_1; pfam01527 243160007577 HTH-like domain; Region: HTH_21; pfam13276 243160007578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007579 Integrase core domain; Region: rve; pfam00665 243160007580 Integrase core domain; Region: rve_3; pfam13683 243160007581 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 243160007582 Cytochrome c; Region: Cytochrom_C; cl11414 243160007583 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243160007584 BON domain; Region: BON; pfam04972 243160007585 BON domain; Region: BON; pfam04972 243160007586 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243160007587 dimer interface [polypeptide binding]; other site 243160007588 active site 243160007589 hypothetical protein; Provisional; Region: PRK14673 243160007590 Predicted methyltransferases [General function prediction only]; Region: COG0313 243160007591 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243160007592 putative SAM binding site [chemical binding]; other site 243160007593 putative homodimer interface [polypeptide binding]; other site 243160007594 Transposase domain (DUF772); Region: DUF772; pfam05598 243160007595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160007596 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160007597 putative chaperone; Provisional; Region: PRK11678 243160007598 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 243160007599 nucleotide binding site [chemical binding]; other site 243160007600 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243160007601 SBD interface [polypeptide binding]; other site 243160007602 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 243160007603 putative FMN binding site [chemical binding]; other site 243160007604 D-galactonate transporter; Region: 2A0114; TIGR00893 243160007605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160007606 putative substrate translocation pore; other site 243160007607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160007608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160007609 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 243160007610 Methyltransferase domain; Region: Methyltransf_32; pfam13679 243160007611 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160007612 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 243160007613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160007614 S-adenosylmethionine binding site [chemical binding]; other site 243160007615 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160007616 Water Stress and Hypersensitive response; Region: WHy; smart00769 243160007617 Peptidase family M1; Region: Peptidase_M1; pfam01433 243160007618 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 243160007619 Zn binding site [ion binding]; other site 243160007620 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 243160007621 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160007622 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160007623 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 243160007624 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 243160007625 putative active site [active] 243160007626 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160007627 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 243160007628 Walker A/P-loop; other site 243160007629 ATP binding site [chemical binding]; other site 243160007630 Q-loop/lid; other site 243160007631 ABC transporter signature motif; other site 243160007632 Walker B; other site 243160007633 D-loop; other site 243160007634 H-loop/switch region; other site 243160007635 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243160007636 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 243160007637 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 243160007638 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 243160007639 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 243160007640 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 243160007641 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 243160007642 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243160007643 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160007644 ligand binding site [chemical binding]; other site 243160007645 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 243160007646 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 243160007647 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 243160007648 Clp amino terminal domain; Region: Clp_N; pfam02861 243160007649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160007650 Walker A motif; other site 243160007651 ATP binding site [chemical binding]; other site 243160007652 Walker B motif; other site 243160007653 arginine finger; other site 243160007654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160007655 Walker A motif; other site 243160007656 ATP binding site [chemical binding]; other site 243160007657 Walker B motif; other site 243160007658 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243160007659 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 243160007660 HTH-like domain; Region: HTH_21; pfam13276 243160007661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007662 Integrase core domain; Region: rve; pfam00665 243160007663 Integrase core domain; Region: rve_3; pfam13683 243160007664 Transposase; Region: HTH_Tnp_1; pfam01527 243160007665 Nitronate monooxygenase; Region: NMO; pfam03060 243160007666 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243160007667 FMN binding site [chemical binding]; other site 243160007668 substrate binding site [chemical binding]; other site 243160007669 putative catalytic residue [active] 243160007670 Dienelactone hydrolase family; Region: DLH; pfam01738 243160007671 amidase; Provisional; Region: PRK07869 243160007672 Amidase; Region: Amidase; cl11426 243160007673 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243160007674 FAD binding site [chemical binding]; other site 243160007675 Predicted membrane protein [Function unknown]; Region: COG1950 243160007676 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 243160007677 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243160007678 homotetramer interface [polypeptide binding]; other site 243160007679 ligand binding site [chemical binding]; other site 243160007680 catalytic site [active] 243160007681 NAD binding site [chemical binding]; other site 243160007682 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 243160007683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160007684 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243160007685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160007686 DNA binding residues [nucleotide binding] 243160007687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243160007688 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 243160007689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243160007690 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 243160007691 FHIPEP family; Region: FHIPEP; pfam00771 243160007692 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 243160007693 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 243160007694 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243160007695 dimer interface [polypeptide binding]; other site 243160007696 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 243160007697 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 243160007698 chemotaxis regulator CheZ; Provisional; Region: PRK11166 243160007699 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 243160007700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160007701 active site 243160007702 phosphorylation site [posttranslational modification] 243160007703 intermolecular recognition site; other site 243160007704 dimerization interface [polypeptide binding]; other site 243160007705 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 243160007706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160007707 active site 243160007708 phosphorylation site [posttranslational modification] 243160007709 intermolecular recognition site; other site 243160007710 dimerization interface [polypeptide binding]; other site 243160007711 CheB methylesterase; Region: CheB_methylest; pfam01339 243160007712 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 243160007713 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 243160007714 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243160007715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160007716 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 243160007717 dimer interface [polypeptide binding]; other site 243160007718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160007719 dimerization interface [polypeptide binding]; other site 243160007720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160007721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160007722 dimer interface [polypeptide binding]; other site 243160007723 putative CheW interface [polypeptide binding]; other site 243160007724 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243160007725 putative CheA interaction surface; other site 243160007726 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243160007727 putative binding surface; other site 243160007728 active site 243160007729 CheY binding; Region: CheY-binding; pfam09078 243160007730 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 243160007731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160007732 ATP binding site [chemical binding]; other site 243160007733 Mg2+ binding site [ion binding]; other site 243160007734 G-X-G motif; other site 243160007735 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 243160007736 Response regulator receiver domain; Region: Response_reg; pfam00072 243160007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160007738 active site 243160007739 phosphorylation site [posttranslational modification] 243160007740 intermolecular recognition site; other site 243160007741 dimerization interface [polypeptide binding]; other site 243160007742 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 243160007743 flagellar motor protein MotA; Validated; Region: PRK09110 243160007744 transcriptional activator FlhC; Provisional; Region: PRK12722 243160007745 transcriptional activator FlhD; Provisional; Region: PRK02909 243160007746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160007747 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243160007748 putative ADP-binding pocket [chemical binding]; other site 243160007749 H-NS histone family; Region: Histone_HNS; pfam00816 243160007750 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160007751 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 243160007752 amphipathic channel; other site 243160007753 Asn-Pro-Ala signature motifs; other site 243160007754 putative hydrolase; Provisional; Region: PRK10976 243160007755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160007756 active site 243160007757 motif I; other site 243160007758 motif II; other site 243160007759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160007760 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 243160007761 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 243160007762 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243160007763 flagellin; Reviewed; Region: PRK08869 243160007764 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243160007765 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243160007766 flagellar capping protein; Reviewed; Region: fliD; PRK08032 243160007767 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 243160007768 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243160007769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160007770 TPR motif; other site 243160007771 binding surface 243160007772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160007773 binding surface 243160007774 TPR motif; other site 243160007775 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 243160007776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160007777 TPR motif; other site 243160007778 binding surface 243160007779 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 243160007780 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243160007781 inhibitor-cofactor binding pocket; inhibition site 243160007782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160007783 catalytic residue [active] 243160007784 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243160007785 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243160007786 dimer interface [polypeptide binding]; other site 243160007787 active site 243160007788 CoA binding pocket [chemical binding]; other site 243160007789 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243160007790 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243160007791 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243160007792 dimer interface [polypeptide binding]; other site 243160007793 active site 243160007794 CoA binding pocket [chemical binding]; other site 243160007795 short chain dehydrogenase; Provisional; Region: PRK06500 243160007796 classical (c) SDRs; Region: SDR_c; cd05233 243160007797 NAD(P) binding site [chemical binding]; other site 243160007798 active site 243160007799 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 243160007800 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 243160007801 putative trimer interface [polypeptide binding]; other site 243160007802 putative CoA binding site [chemical binding]; other site 243160007803 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243160007804 iron-sulfur cluster [ion binding]; other site 243160007805 [2Fe-2S] cluster binding site [ion binding]; other site 243160007806 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243160007807 alpha subunit interface [polypeptide binding]; other site 243160007808 active site 243160007809 substrate binding site [chemical binding]; other site 243160007810 Fe binding site [ion binding]; other site 243160007811 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243160007812 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160007813 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 243160007814 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 243160007815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 243160007816 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 243160007817 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 243160007818 Cache domain; Region: Cache_1; pfam02743 243160007819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160007820 dimerization interface [polypeptide binding]; other site 243160007821 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160007822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160007823 dimer interface [polypeptide binding]; other site 243160007824 putative CheW interface [polypeptide binding]; other site 243160007825 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160007826 FAD binding domain; Region: FAD_binding_4; pfam01565 243160007827 Berberine and berberine like; Region: BBE; pfam08031 243160007828 Chitin binding domain; Region: Chitin_bind_3; pfam03067 243160007829 Transposase; Region: HTH_Tnp_1; pfam01527 243160007830 HTH-like domain; Region: HTH_21; pfam13276 243160007831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160007832 Integrase core domain; Region: rve; pfam00665 243160007833 Integrase core domain; Region: rve_3; pfam13683 243160007834 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160007835 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 243160007836 dimerization interface [polypeptide binding]; other site 243160007837 ligand binding site [chemical binding]; other site 243160007838 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 243160007839 H-NS histone family; Region: Histone_HNS; pfam00816 243160007840 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160007841 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243160007842 Cation efflux family; Region: Cation_efflux; pfam01545 243160007843 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160007844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160007845 putative DNA binding site [nucleotide binding]; other site 243160007846 putative Zn2+ binding site [ion binding]; other site 243160007847 AsnC family; Region: AsnC_trans_reg; pfam01037 243160007848 active site 243160007849 catalytic site [active] 243160007850 substrate binding site [chemical binding]; other site 243160007851 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 243160007852 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243160007853 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 243160007854 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243160007855 Transposase domain (DUF772); Region: DUF772; pfam05598 243160007856 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160007857 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160007858 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243160007859 IHF dimer interface [polypeptide binding]; other site 243160007860 IHF - DNA interface [nucleotide binding]; other site 243160007861 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 243160007862 Uncharacterized conserved protein [Function unknown]; Region: COG4121 243160007863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243160007864 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243160007865 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 243160007866 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 243160007867 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243160007868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160007869 dimerization interface [polypeptide binding]; other site 243160007870 putative DNA binding site [nucleotide binding]; other site 243160007871 putative Zn2+ binding site [ion binding]; other site 243160007872 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 243160007873 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 243160007874 catalytic triad [active] 243160007875 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243160007876 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 243160007877 active site 243160007878 FMN binding site [chemical binding]; other site 243160007879 substrate binding site [chemical binding]; other site 243160007880 homotetramer interface [polypeptide binding]; other site 243160007881 catalytic residue [active] 243160007882 Proteins containing SET domain [General function prediction only]; Region: COG2940 243160007883 SET domain; Region: SET; pfam00856 243160007884 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 243160007885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160007886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160007887 dimer interface [polypeptide binding]; other site 243160007888 phosphorylation site [posttranslational modification] 243160007889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160007890 ATP binding site [chemical binding]; other site 243160007891 Mg2+ binding site [ion binding]; other site 243160007892 G-X-G motif; other site 243160007893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160007894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160007895 active site 243160007896 phosphorylation site [posttranslational modification] 243160007897 intermolecular recognition site; other site 243160007898 dimerization interface [polypeptide binding]; other site 243160007899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160007900 DNA binding site [nucleotide binding] 243160007901 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 243160007902 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 243160007903 aromatic arch; other site 243160007904 DCoH dimer interaction site [polypeptide binding]; other site 243160007905 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243160007906 DCoH tetramer interaction site [polypeptide binding]; other site 243160007907 substrate binding site [chemical binding]; other site 243160007908 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 243160007909 cofactor binding site; other site 243160007910 metal binding site [ion binding]; metal-binding site 243160007911 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160007912 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243160007913 putative DNA binding site [nucleotide binding]; other site 243160007914 putative Zn2+ binding site [ion binding]; other site 243160007915 AsnC family; Region: AsnC_trans_reg; pfam01037 243160007916 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 243160007917 putative active site [active] 243160007918 putative metal binding residues [ion binding]; other site 243160007919 signature motif; other site 243160007920 putative triphosphate binding site [ion binding]; other site 243160007921 dimer interface [polypeptide binding]; other site 243160007922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160007923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160007924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160007925 dimerization interface [polypeptide binding]; other site 243160007926 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 243160007927 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 243160007928 tetrameric interface [polypeptide binding]; other site 243160007929 NAD binding site [chemical binding]; other site 243160007930 catalytic residues [active] 243160007931 choline dehydrogenase; Validated; Region: PRK02106 243160007932 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160007933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243160007934 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243160007935 Walker A/P-loop; other site 243160007936 ATP binding site [chemical binding]; other site 243160007937 Q-loop/lid; other site 243160007938 ABC transporter signature motif; other site 243160007939 Walker B; other site 243160007940 D-loop; other site 243160007941 H-loop/switch region; other site 243160007942 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243160007943 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 243160007944 putative ligand binding site [chemical binding]; other site 243160007945 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160007946 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243160007947 TM-ABC transporter signature motif; other site 243160007948 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160007949 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 243160007950 putative ligand binding site [chemical binding]; other site 243160007951 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243160007952 TM-ABC transporter signature motif; other site 243160007953 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 243160007954 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243160007955 TM-ABC transporter signature motif; other site 243160007956 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243160007957 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243160007958 Walker A/P-loop; other site 243160007959 ATP binding site [chemical binding]; other site 243160007960 Q-loop/lid; other site 243160007961 ABC transporter signature motif; other site 243160007962 Walker B; other site 243160007963 D-loop; other site 243160007964 H-loop/switch region; other site 243160007965 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243160007966 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243160007967 Walker A/P-loop; other site 243160007968 ATP binding site [chemical binding]; other site 243160007969 Q-loop/lid; other site 243160007970 ABC transporter signature motif; other site 243160007971 Walker B; other site 243160007972 D-loop; other site 243160007973 H-loop/switch region; other site 243160007974 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 243160007975 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 243160007976 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243160007977 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243160007978 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 243160007979 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 243160007980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243160007981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243160007982 P-loop; other site 243160007983 Magnesium ion binding site [ion binding]; other site 243160007984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243160007985 Magnesium ion binding site [ion binding]; other site 243160007986 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243160007987 ParB-like nuclease domain; Region: ParBc; pfam02195 243160007988 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243160007989 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243160007990 transmembrane helices; other site 243160007991 ATP synthase I chain; Region: ATP_synt_I; cl09170 243160007992 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 243160007993 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243160007994 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 243160007995 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243160007996 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 243160007997 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 243160007998 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 243160007999 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243160008000 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243160008001 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243160008002 beta subunit interaction interface [polypeptide binding]; other site 243160008003 Walker A motif; other site 243160008004 ATP binding site [chemical binding]; other site 243160008005 Walker B motif; other site 243160008006 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243160008007 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243160008008 core domain interface [polypeptide binding]; other site 243160008009 delta subunit interface [polypeptide binding]; other site 243160008010 epsilon subunit interface [polypeptide binding]; other site 243160008011 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243160008012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243160008013 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243160008014 alpha subunit interaction interface [polypeptide binding]; other site 243160008015 Walker A motif; other site 243160008016 ATP binding site [chemical binding]; other site 243160008017 Walker B motif; other site 243160008018 inhibitor binding site; inhibition site 243160008019 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243160008020 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243160008021 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243160008022 gamma subunit interface [polypeptide binding]; other site 243160008023 epsilon subunit interface [polypeptide binding]; other site 243160008024 LBP interface [polypeptide binding]; other site 243160008025 AMP-binding domain protein; Validated; Region: PRK08315 243160008026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008027 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243160008028 acyl-activating enzyme (AAE) consensus motif; other site 243160008029 putative AMP binding site [chemical binding]; other site 243160008030 putative active site [active] 243160008031 putative CoA binding site [chemical binding]; other site 243160008032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160008033 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160008034 substrate binding pocket [chemical binding]; other site 243160008035 membrane-bound complex binding site; other site 243160008036 hinge residues; other site 243160008037 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 243160008038 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243160008039 substrate binding site [chemical binding]; other site 243160008040 active site 243160008041 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 243160008042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160008043 ATP binding site [chemical binding]; other site 243160008044 putative Mg++ binding site [ion binding]; other site 243160008045 nucleotide binding region [chemical binding]; other site 243160008046 helicase superfamily c-terminal domain; Region: HELICc; smart00490 243160008047 ATP-binding site [chemical binding]; other site 243160008048 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008049 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 243160008050 Predicted transcriptional regulator [Transcription]; Region: COG3905 243160008051 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 243160008052 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 243160008053 Glutamate binding site [chemical binding]; other site 243160008054 NAD binding site [chemical binding]; other site 243160008055 catalytic residues [active] 243160008056 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160008057 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160008058 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 243160008059 dimerization interface [polypeptide binding]; other site 243160008060 ligand binding site [chemical binding]; other site 243160008061 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243160008062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008063 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243160008064 acyl-activating enzyme (AAE) consensus motif; other site 243160008065 acyl-activating enzyme (AAE) consensus motif; other site 243160008066 putative AMP binding site [chemical binding]; other site 243160008067 putative active site [active] 243160008068 putative CoA binding site [chemical binding]; other site 243160008069 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 243160008070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160008071 active site 243160008072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160008073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160008074 putative aminotransferase; Provisional; Region: PRK12414 243160008075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160008076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008077 homodimer interface [polypeptide binding]; other site 243160008078 catalytic residue [active] 243160008079 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 243160008080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160008081 substrate binding pocket [chemical binding]; other site 243160008082 membrane-bound complex binding site; other site 243160008083 hinge residues; other site 243160008084 Predicted transcriptional regulators [Transcription]; Region: COG1695 243160008085 Transcriptional regulator PadR-like family; Region: PadR; cl17335 243160008086 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 243160008087 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 243160008088 DNA binding residues [nucleotide binding] 243160008089 dimer interface [polypeptide binding]; other site 243160008090 putative metal binding site [ion binding]; other site 243160008091 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243160008092 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 243160008093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243160008094 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243160008095 Conserved TM helix; Region: TM_helix; pfam05552 243160008096 Conserved TM helix; Region: TM_helix; pfam05552 243160008097 Conserved TM helix; Region: TM_helix; pfam05552 243160008098 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 243160008099 Acyltransferase family; Region: Acyl_transf_3; pfam01757 243160008100 ethanolamine permease; Region: 2A0305; TIGR00908 243160008101 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008103 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008104 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 243160008105 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 243160008106 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 243160008107 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 243160008108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160008109 NAD(P) binding site [chemical binding]; other site 243160008110 catalytic residues [active] 243160008111 Helix-turn-helix domain; Region: HTH_18; pfam12833 243160008112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160008113 thiamine pyrophosphate protein; Validated; Region: PRK08199 243160008114 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160008115 PYR/PP interface [polypeptide binding]; other site 243160008116 dimer interface [polypeptide binding]; other site 243160008117 TPP binding site [chemical binding]; other site 243160008118 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160008119 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 243160008120 TPP-binding site [chemical binding]; other site 243160008121 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 243160008122 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 243160008123 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 243160008124 Alginate lyase; Region: Alginate_lyase; pfam05426 243160008125 glycine dehydrogenase; Provisional; Region: PRK05367 243160008126 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243160008127 tetramer interface [polypeptide binding]; other site 243160008128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008129 catalytic residue [active] 243160008130 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243160008131 tetramer interface [polypeptide binding]; other site 243160008132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008133 catalytic residue [active] 243160008134 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243160008135 lipoyl attachment site [posttranslational modification]; other site 243160008136 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243160008137 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243160008138 putative oxidoreductase; Provisional; Region: PRK11579 243160008139 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243160008140 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243160008141 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 243160008142 oxyanion hole [active] 243160008143 active site 243160008144 catalytic triad [active] 243160008145 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 243160008146 Part of AAA domain; Region: AAA_19; pfam13245 243160008147 Family description; Region: UvrD_C_2; pfam13538 243160008148 Cytochrome c; Region: Cytochrom_C; cl11414 243160008149 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 243160008150 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 243160008151 Int/Topo IB signature motif; other site 243160008152 HTH-like domain; Region: HTH_21; pfam13276 243160008153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160008154 Integrase core domain; Region: rve; pfam00665 243160008155 Integrase core domain; Region: rve_3; pfam13683 243160008156 Transposase; Region: HTH_Tnp_1; pfam01527 243160008157 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 243160008158 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 243160008159 active site 243160008160 homotetramer interface [polypeptide binding]; other site 243160008161 Predicted ATPase [General function prediction only]; Region: COG3911 243160008162 AAA domain; Region: AAA_28; pfam13521 243160008163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160008165 putative substrate translocation pore; other site 243160008166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 243160008167 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243160008168 substrate binding site [chemical binding]; other site 243160008169 ecotin; Provisional; Region: PRK03719 243160008170 secondary substrate binding site; other site 243160008171 primary substrate binding site; other site 243160008172 inhibition loop; other site 243160008173 dimerization interface [polypeptide binding]; other site 243160008174 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243160008175 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243160008176 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 243160008177 Transposase; Region: HTH_Tnp_1; pfam01527 243160008178 HTH-like domain; Region: HTH_21; pfam13276 243160008179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160008180 Integrase core domain; Region: rve; pfam00665 243160008181 Integrase core domain; Region: rve_3; pfam13683 243160008182 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 243160008183 Acyl transferase domain; Region: Acyl_transf_1; cl08282 243160008184 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 243160008185 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 243160008186 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 243160008187 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 243160008188 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 243160008189 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 243160008190 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 243160008191 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 243160008192 Malonate transporter MadL subunit; Region: MadL; cl04273 243160008193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160008194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160008195 LysR substrate binding domain; Region: LysR_substrate; pfam03466 243160008196 dimerization interface [polypeptide binding]; other site 243160008197 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 243160008198 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243160008199 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160008200 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 243160008201 active site 243160008202 substrate-binding site [chemical binding]; other site 243160008203 metal-binding site [ion binding] 243160008204 GTP binding site [chemical binding]; other site 243160008205 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 243160008206 dimerization interface [polypeptide binding]; other site 243160008207 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243160008208 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243160008209 putative dimer interface [polypeptide binding]; other site 243160008210 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160008211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160008212 DNA-binding site [nucleotide binding]; DNA binding site 243160008213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160008214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008215 homodimer interface [polypeptide binding]; other site 243160008216 catalytic residue [active] 243160008217 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 243160008218 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160008219 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160008220 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 243160008221 short chain dehydrogenase; Provisional; Region: PRK12744 243160008222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160008223 NAD(P) binding site [chemical binding]; other site 243160008224 active site 243160008225 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 243160008226 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 243160008227 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243160008228 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243160008229 glutaminase active site [active] 243160008230 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243160008231 dimer interface [polypeptide binding]; other site 243160008232 active site 243160008233 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243160008234 dimer interface [polypeptide binding]; other site 243160008235 active site 243160008236 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160008237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160008238 putative DNA binding site [nucleotide binding]; other site 243160008239 putative Zn2+ binding site [ion binding]; other site 243160008240 AsnC family; Region: AsnC_trans_reg; pfam01037 243160008241 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160008242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160008243 DNA-binding site [nucleotide binding]; DNA binding site 243160008244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160008245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008246 homodimer interface [polypeptide binding]; other site 243160008247 catalytic residue [active] 243160008248 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 243160008249 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 243160008250 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 243160008251 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 243160008252 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160008253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160008254 metal binding site [ion binding]; metal-binding site 243160008255 active site 243160008256 I-site; other site 243160008257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243160008258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243160008259 DNA binding site [nucleotide binding] 243160008260 domain linker motif; other site 243160008261 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 243160008262 putative dimerization interface [polypeptide binding]; other site 243160008263 putative ligand binding site [chemical binding]; other site 243160008264 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160008265 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243160008266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 243160008267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160008268 putative PBP binding loops; other site 243160008269 ABC-ATPase subunit interface; other site 243160008270 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243160008271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160008272 Walker A/P-loop; other site 243160008273 ATP binding site [chemical binding]; other site 243160008274 Q-loop/lid; other site 243160008275 ABC transporter signature motif; other site 243160008276 Walker B; other site 243160008277 D-loop; other site 243160008278 H-loop/switch region; other site 243160008279 TOBE domain; Region: TOBE_2; pfam08402 243160008280 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 243160008281 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160008282 active site 243160008283 metal binding site [ion binding]; metal-binding site 243160008284 hexamer interface [polypeptide binding]; other site 243160008285 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160008286 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160008287 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243160008288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008289 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243160008290 EamA-like transporter family; Region: EamA; pfam00892 243160008291 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243160008292 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243160008293 Moco binding site; other site 243160008294 metal coordination site [ion binding]; other site 243160008295 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 243160008296 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 243160008297 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 243160008298 ThiC-associated domain; Region: ThiC-associated; pfam13667 243160008299 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 243160008300 HTH-like domain; Region: HTH_21; pfam13276 243160008301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160008302 Integrase core domain; Region: rve; pfam00665 243160008303 Integrase core domain; Region: rve_3; pfam13683 243160008304 Transposase; Region: HTH_Tnp_1; pfam01527 243160008305 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243160008306 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243160008307 dimer interface [polypeptide binding]; other site 243160008308 ssDNA binding site [nucleotide binding]; other site 243160008309 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243160008310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160008312 putative substrate translocation pore; other site 243160008313 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243160008314 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243160008315 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243160008316 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243160008317 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243160008318 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 243160008319 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 243160008320 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 243160008321 putative active site [active] 243160008322 putative substrate binding site [chemical binding]; other site 243160008323 putative cosubstrate binding site; other site 243160008324 catalytic site [active] 243160008325 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243160008326 nudix motif; other site 243160008327 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160008328 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243160008329 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243160008330 TrkA-N domain; Region: TrkA_N; pfam02254 243160008331 TrkA-C domain; Region: TrkA_C; pfam02080 243160008332 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 243160008333 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 243160008334 putative active site [active] 243160008335 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 243160008336 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 243160008337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160008338 active site 243160008339 motif I; other site 243160008340 motif II; other site 243160008341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 243160008342 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 243160008343 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 243160008344 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 243160008345 Walker A/P-loop; other site 243160008346 ATP binding site [chemical binding]; other site 243160008347 Q-loop/lid; other site 243160008348 ABC transporter signature motif; other site 243160008349 Walker B; other site 243160008350 D-loop; other site 243160008351 H-loop/switch region; other site 243160008352 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 243160008353 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 243160008354 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 243160008355 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243160008356 30S subunit binding site; other site 243160008357 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 243160008358 active site 243160008359 phosphorylation site [posttranslational modification] 243160008360 HPr kinase/phosphorylase; Provisional; Region: PRK05428 243160008361 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 243160008362 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 243160008363 Hpr binding site; other site 243160008364 active site 243160008365 homohexamer subunit interaction site [polypeptide binding]; other site 243160008366 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 243160008367 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243160008368 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 243160008369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243160008370 minor groove reading motif; other site 243160008371 helix-hairpin-helix signature motif; other site 243160008372 active site 243160008373 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 243160008374 DNA binding and oxoG recognition site [nucleotide binding] 243160008375 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243160008376 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243160008377 DNA binding site [nucleotide binding] 243160008378 catalytic residue [active] 243160008379 H2TH interface [polypeptide binding]; other site 243160008380 putative catalytic residues [active] 243160008381 turnover-facilitating residue; other site 243160008382 intercalation triad [nucleotide binding]; other site 243160008383 8OG recognition residue [nucleotide binding]; other site 243160008384 putative reading head residues; other site 243160008385 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243160008386 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243160008387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 243160008388 binding surface 243160008389 TPR motif; other site 243160008390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160008391 binding surface 243160008392 TPR motif; other site 243160008393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160008394 binding surface 243160008395 TPR motif; other site 243160008396 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 243160008397 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 243160008398 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 243160008399 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 243160008400 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243160008401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160008402 active site 243160008403 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 243160008404 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243160008405 5S rRNA interface [nucleotide binding]; other site 243160008406 CTC domain interface [polypeptide binding]; other site 243160008407 L16 interface [polypeptide binding]; other site 243160008408 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243160008409 putative active site [active] 243160008410 catalytic residue [active] 243160008411 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 243160008412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160008413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008414 homodimer interface [polypeptide binding]; other site 243160008415 catalytic residue [active] 243160008416 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243160008417 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 243160008418 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243160008419 active site 243160008420 (T/H)XGH motif; other site 243160008421 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 243160008422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160008423 S-adenosylmethionine binding site [chemical binding]; other site 243160008424 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 243160008425 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243160008426 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243160008427 P loop; other site 243160008428 GTP binding site [chemical binding]; other site 243160008429 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 243160008430 maleylacetoacetate isomerase; Region: maiA; TIGR01262 243160008431 C-terminal domain interface [polypeptide binding]; other site 243160008432 GSH binding site (G-site) [chemical binding]; other site 243160008433 putative dimer interface [polypeptide binding]; other site 243160008434 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 243160008435 dimer interface [polypeptide binding]; other site 243160008436 N-terminal domain interface [polypeptide binding]; other site 243160008437 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 243160008438 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 243160008439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160008440 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243160008441 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243160008442 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160008443 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 243160008444 [2Fe-2S] cluster binding site [ion binding]; other site 243160008445 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926 243160008446 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 243160008447 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243160008448 molybdopterin cofactor binding site; other site 243160008449 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 243160008450 molybdopterin cofactor binding site; other site 243160008451 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243160008452 glycosyl transferase family protein; Provisional; Region: PRK08136 243160008453 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243160008454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160008455 Coenzyme A binding pocket [chemical binding]; other site 243160008456 2-isopropylmalate synthase; Validated; Region: PRK03739 243160008457 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 243160008458 active site 243160008459 catalytic residues [active] 243160008460 metal binding site [ion binding]; metal-binding site 243160008461 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 243160008462 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 243160008463 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243160008464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160008465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160008466 DNA binding residues [nucleotide binding] 243160008467 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008469 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008470 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 243160008471 zinc binding site [ion binding]; other site 243160008472 putative ligand binding site [chemical binding]; other site 243160008473 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160008474 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 243160008475 TM-ABC transporter signature motif; other site 243160008476 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 243160008477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160008478 Walker A/P-loop; other site 243160008479 ATP binding site [chemical binding]; other site 243160008480 Q-loop/lid; other site 243160008481 ABC transporter signature motif; other site 243160008482 Walker B; other site 243160008483 D-loop; other site 243160008484 H-loop/switch region; other site 243160008485 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 243160008486 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 243160008487 putative active site [active] 243160008488 putative PHP Thumb interface [polypeptide binding]; other site 243160008489 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243160008490 generic binding surface II; other site 243160008491 generic binding surface I; other site 243160008492 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 243160008493 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243160008494 putative di-iron ligands [ion binding]; other site 243160008495 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 243160008496 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 243160008497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160008498 inhibitor-cofactor binding pocket; inhibition site 243160008499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160008500 catalytic residue [active] 243160008501 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160008502 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243160008503 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 243160008504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160008505 Walker A/P-loop; other site 243160008506 ATP binding site [chemical binding]; other site 243160008507 Q-loop/lid; other site 243160008508 ABC transporter signature motif; other site 243160008509 Walker B; other site 243160008510 D-loop; other site 243160008511 H-loop/switch region; other site 243160008512 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160008513 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160008514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160008515 S-adenosylmethionine binding site [chemical binding]; other site 243160008516 Citrate synthase; Region: Citrate_synt; pfam00285 243160008517 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 243160008518 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 243160008519 citrylCoA binding site [chemical binding]; other site 243160008520 oxalacetate binding site [chemical binding]; other site 243160008521 coenzyme A binding site [chemical binding]; other site 243160008522 catalytic triad [active] 243160008523 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 243160008524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160008525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160008526 active site 243160008527 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 243160008528 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243160008529 active site 243160008530 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243160008531 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008533 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160008534 acyl-activating enzyme (AAE) consensus motif; other site 243160008535 acyl-activating enzyme (AAE) consensus motif; other site 243160008536 AMP binding site [chemical binding]; other site 243160008537 active site 243160008538 CoA binding site [chemical binding]; other site 243160008539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 243160008540 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243160008541 dimer interface [polypeptide binding]; other site 243160008542 active site 243160008543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160008544 catalytic residues [active] 243160008545 substrate binding site [chemical binding]; other site 243160008546 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243160008547 active site 243160008548 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243160008549 acyl-CoA synthetase; Validated; Region: PRK09192 243160008550 acyl-activating enzyme (AAE) consensus motif; other site 243160008551 active site 243160008552 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 243160008553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160008554 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243160008555 dimerization interface [polypeptide binding]; other site 243160008556 substrate binding pocket [chemical binding]; other site 243160008557 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243160008558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160008559 DNA-binding site [nucleotide binding]; DNA binding site 243160008560 UTRA domain; Region: UTRA; pfam07702 243160008561 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 243160008562 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 243160008563 active site 243160008564 dimer interface [polypeptide binding]; other site 243160008565 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 243160008566 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243160008567 dimer interface [polypeptide binding]; other site 243160008568 active site 243160008569 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243160008570 dimer interface [polypeptide binding]; other site 243160008571 active site 243160008572 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 243160008573 HPr interaction site; other site 243160008574 glycerol kinase (GK) interaction site [polypeptide binding]; other site 243160008575 active site 243160008576 phosphorylation site [posttranslational modification] 243160008577 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243160008578 dimerization domain swap beta strand [polypeptide binding]; other site 243160008579 regulatory protein interface [polypeptide binding]; other site 243160008580 active site 243160008581 regulatory phosphorylation site [posttranslational modification]; other site 243160008582 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243160008583 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 243160008584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243160008585 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243160008586 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 243160008587 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 243160008588 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 243160008589 active site turn [active] 243160008590 phosphorylation site [posttranslational modification] 243160008591 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 243160008592 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 243160008593 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 243160008594 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 243160008595 active site 243160008596 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 243160008597 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 243160008598 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243160008599 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 243160008600 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 243160008601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160008602 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160008603 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008604 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008605 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008606 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 243160008607 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 243160008608 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243160008609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243160008610 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160008611 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160008612 dimer interface [polypeptide binding]; other site 243160008613 putative CheW interface [polypeptide binding]; other site 243160008614 YCII-related domain; Region: YCII; cl00999 243160008615 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243160008616 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160008617 Cu(I) binding site [ion binding]; other site 243160008618 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 243160008619 UbiA prenyltransferase family; Region: UbiA; pfam01040 243160008620 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 243160008621 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 243160008622 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 243160008623 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 243160008624 Subunit III/VIIa interface [polypeptide binding]; other site 243160008625 Phospholipid binding site [chemical binding]; other site 243160008626 Subunit I/III interface [polypeptide binding]; other site 243160008627 Subunit III/VIb interface [polypeptide binding]; other site 243160008628 Subunit III/VIa interface; other site 243160008629 Subunit III/Vb interface [polypeptide binding]; other site 243160008630 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 243160008631 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 243160008632 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243160008633 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 243160008634 Subunit I/III interface [polypeptide binding]; other site 243160008635 D-pathway; other site 243160008636 Subunit I/VIIc interface [polypeptide binding]; other site 243160008637 Subunit I/IV interface [polypeptide binding]; other site 243160008638 Subunit I/II interface [polypeptide binding]; other site 243160008639 Low-spin heme (heme a) binding site [chemical binding]; other site 243160008640 Subunit I/VIIa interface [polypeptide binding]; other site 243160008641 Subunit I/VIa interface [polypeptide binding]; other site 243160008642 Dimer interface; other site 243160008643 Putative water exit pathway; other site 243160008644 Binuclear center (heme a3/CuB) [ion binding]; other site 243160008645 K-pathway; other site 243160008646 Subunit I/Vb interface [polypeptide binding]; other site 243160008647 Putative proton exit pathway; other site 243160008648 Subunit I/VIb interface; other site 243160008649 Subunit I/VIc interface [polypeptide binding]; other site 243160008650 Electron transfer pathway; other site 243160008651 Subunit I/VIIIb interface [polypeptide binding]; other site 243160008652 Subunit I/VIIb interface [polypeptide binding]; other site 243160008653 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 243160008654 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 243160008655 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243160008656 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160008657 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243160008658 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243160008659 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160008660 ligand binding site [chemical binding]; other site 243160008661 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 243160008662 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 243160008663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160008664 active site 243160008665 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243160008666 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 243160008667 putative ADP-ribose binding site [chemical binding]; other site 243160008668 putative active site [active] 243160008669 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 243160008670 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 243160008671 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 243160008672 preprotein translocase subunit SecB; Validated; Region: PRK05751 243160008673 SecA binding site; other site 243160008674 Preprotein binding site; other site 243160008675 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 243160008676 GSH binding site [chemical binding]; other site 243160008677 catalytic residues [active] 243160008678 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243160008679 active site residue [active] 243160008680 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160008681 catalytic core [active] 243160008682 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160008683 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 243160008684 C-terminal peptidase (prc); Region: prc; TIGR00225 243160008685 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243160008686 protein binding site [polypeptide binding]; other site 243160008687 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243160008688 Catalytic dyad [active] 243160008689 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 243160008690 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243160008691 ATP binding site [chemical binding]; other site 243160008692 substrate interface [chemical binding]; other site 243160008693 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243160008694 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 243160008695 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243160008696 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243160008697 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243160008698 dimerization domain swap beta strand [polypeptide binding]; other site 243160008699 regulatory protein interface [polypeptide binding]; other site 243160008700 active site 243160008701 regulatory phosphorylation site [posttranslational modification]; other site 243160008702 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 243160008703 active pocket/dimerization site; other site 243160008704 active site 243160008705 phosphorylation site [posttranslational modification] 243160008706 glutathione synthetase; Provisional; Region: PRK05246 243160008707 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 243160008708 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 243160008709 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 243160008710 Glutamate-cysteine ligase; Region: GshA; pfam08886 243160008711 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008712 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008713 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008714 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243160008715 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243160008716 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243160008717 Membrane fusogenic activity; Region: BMFP; pfam04380 243160008718 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243160008719 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243160008720 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 243160008721 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 243160008722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243160008723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160008724 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 243160008725 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243160008726 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160008727 catalytic residues [active] 243160008728 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160008729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160008730 active site 243160008731 phosphorylation site [posttranslational modification] 243160008732 intermolecular recognition site; other site 243160008733 dimerization interface [polypeptide binding]; other site 243160008734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160008735 Walker A motif; other site 243160008736 ATP binding site [chemical binding]; other site 243160008737 Walker B motif; other site 243160008738 arginine finger; other site 243160008739 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160008740 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 243160008741 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 243160008742 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 243160008743 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243160008744 Na binding site [ion binding]; other site 243160008745 Protein of unknown function, DUF485; Region: DUF485; pfam04341 243160008746 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243160008747 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243160008748 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 243160008749 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243160008750 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243160008751 active site 243160008752 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 243160008753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160008754 substrate binding site [chemical binding]; other site 243160008755 oxyanion hole (OAH) forming residues; other site 243160008756 trimer interface [polypeptide binding]; other site 243160008757 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243160008758 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160008759 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160008760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160008761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160008762 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160008763 putative effector binding pocket; other site 243160008764 dimerization interface [polypeptide binding]; other site 243160008765 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243160008766 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243160008767 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243160008768 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008770 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008771 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243160008772 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243160008773 putative NAD(P) binding site [chemical binding]; other site 243160008774 putative substrate binding site [chemical binding]; other site 243160008775 catalytic Zn binding site [ion binding]; other site 243160008776 structural Zn binding site [ion binding]; other site 243160008777 dimer interface [polypeptide binding]; other site 243160008778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160008779 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160008780 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 243160008781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160008782 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160008783 Peptidase family M48; Region: Peptidase_M48; cl12018 243160008784 muropeptide transporter; Reviewed; Region: ampG; PRK11902 243160008785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008786 putative substrate translocation pore; other site 243160008787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243160008788 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 243160008789 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 243160008790 division inhibitor protein; Provisional; Region: slmA; PRK09480 243160008791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160008792 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 243160008793 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243160008794 feedback inhibition sensing region; other site 243160008795 homohexameric interface [polypeptide binding]; other site 243160008796 nucleotide binding site [chemical binding]; other site 243160008797 N-acetyl-L-glutamate binding site [chemical binding]; other site 243160008798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160008799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 243160008800 dimer interface [polypeptide binding]; other site 243160008801 phosphorylation site [posttranslational modification] 243160008802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160008803 ATP binding site [chemical binding]; other site 243160008804 Mg2+ binding site [ion binding]; other site 243160008805 G-X-G motif; other site 243160008806 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 243160008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160008808 active site 243160008809 phosphorylation site [posttranslational modification] 243160008810 intermolecular recognition site; other site 243160008811 dimerization interface [polypeptide binding]; other site 243160008812 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160008813 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 243160008814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160008815 Walker A motif; other site 243160008816 ATP binding site [chemical binding]; other site 243160008817 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 243160008818 Walker B motif; other site 243160008819 arginine finger; other site 243160008820 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243160008821 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 243160008822 active site 243160008823 HslU subunit interaction site [polypeptide binding]; other site 243160008824 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 243160008825 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 243160008826 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 243160008827 P-loop, Walker A motif; other site 243160008828 Base recognition motif; other site 243160008829 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 243160008830 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243160008831 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 243160008832 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243160008833 putative RNA binding site [nucleotide binding]; other site 243160008834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160008835 S-adenosylmethionine binding site [chemical binding]; other site 243160008836 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243160008837 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243160008838 active site 243160008839 DNA binding site [nucleotide binding] 243160008840 Int/Topo IB signature motif; other site 243160008841 Protein of unknown function, DUF484; Region: DUF484; cl17449 243160008842 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 243160008843 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243160008844 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243160008845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243160008846 putative acyl-acceptor binding pocket; other site 243160008847 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243160008848 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243160008849 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243160008850 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243160008851 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 243160008852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243160008853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243160008854 active site 243160008855 catalytic tetrad [active] 243160008856 EamA-like transporter family; Region: EamA; pfam00892 243160008857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008858 putative substrate translocation pore; other site 243160008859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243160008860 serine/threonine protein kinase; Provisional; Region: PRK11768 243160008861 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 243160008862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160008863 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 243160008864 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 243160008865 NAD(P) binding site [chemical binding]; other site 243160008866 catalytic residues [active] 243160008867 choline dehydrogenase; Validated; Region: PRK02106 243160008868 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160008869 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 243160008870 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 243160008871 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 243160008872 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 243160008873 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 243160008874 Walker A motif/ATP binding site; other site 243160008875 Walker B motif; other site 243160008876 flagellar assembly protein H; Validated; Region: fliH; PRK05687 243160008877 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 243160008878 Flagellar assembly protein FliH; Region: FliH; pfam02108 243160008879 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 243160008880 FliG C-terminal domain; Region: FliG_C; pfam01706 243160008881 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 243160008882 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 243160008883 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 243160008884 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 243160008885 flagellar protein FliS; Validated; Region: fliS; PRK05685 243160008886 Flagellar protein FliT; Region: FliT; cl05125 243160008887 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 243160008888 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 243160008889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 243160008890 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 243160008891 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 243160008892 XdhC Rossmann domain; Region: XdhC_C; pfam13478 243160008893 amino acid transporter; Region: 2A0306; TIGR00909 243160008894 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 243160008895 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160008896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160008897 active site 243160008898 phosphorylation site [posttranslational modification] 243160008899 intermolecular recognition site; other site 243160008900 dimerization interface [polypeptide binding]; other site 243160008901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160008902 DNA binding residues [nucleotide binding] 243160008903 dimerization interface [polypeptide binding]; other site 243160008904 Transposase domain (DUF772); Region: DUF772; pfam05598 243160008905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160008906 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160008907 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243160008908 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 243160008909 FAD binding pocket [chemical binding]; other site 243160008910 FAD binding motif [chemical binding]; other site 243160008911 phosphate binding motif [ion binding]; other site 243160008912 beta-alpha-beta structure motif; other site 243160008913 NAD binding pocket [chemical binding]; other site 243160008914 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160008915 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243160008916 putative catalytic site [active] 243160008917 putative phosphate binding site [ion binding]; other site 243160008918 putative metal binding site [ion binding]; other site 243160008919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160008920 Walker A motif; other site 243160008921 ATP binding site [chemical binding]; other site 243160008922 Walker B motif; other site 243160008923 arginine finger; other site 243160008924 Predicted dehydrogenase [General function prediction only]; Region: COG0579 243160008925 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243160008926 High potential iron-sulfur protein; Region: HIPIP; pfam01355 243160008927 citrate-proton symporter; Provisional; Region: PRK15075 243160008928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160008929 putative substrate translocation pore; other site 243160008930 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243160008931 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 243160008932 peptide binding site [polypeptide binding]; other site 243160008933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243160008934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160008935 dimer interface [polypeptide binding]; other site 243160008936 conserved gate region; other site 243160008937 putative PBP binding loops; other site 243160008938 ABC-ATPase subunit interface; other site 243160008939 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243160008940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160008941 Walker A/P-loop; other site 243160008942 ATP binding site [chemical binding]; other site 243160008943 Q-loop/lid; other site 243160008944 ABC transporter signature motif; other site 243160008945 Walker B; other site 243160008946 D-loop; other site 243160008947 H-loop/switch region; other site 243160008948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160008949 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 243160008950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160008951 Walker A/P-loop; other site 243160008952 ATP binding site [chemical binding]; other site 243160008953 Q-loop/lid; other site 243160008954 ABC transporter signature motif; other site 243160008955 Walker B; other site 243160008956 D-loop; other site 243160008957 H-loop/switch region; other site 243160008958 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 243160008959 TraB family; Region: TraB; pfam01963 243160008960 Predicted membrane protein [Function unknown]; Region: COG3817 243160008961 Protein of unknown function (DUF979); Region: DUF979; pfam06166 243160008962 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 243160008963 putative active site [active] 243160008964 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 243160008965 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 243160008966 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 243160008967 MarR family; Region: MarR_2; cl17246 243160008968 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 243160008969 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 243160008970 lytic murein transglycosylase; Provisional; Region: PRK11619 243160008971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160008972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160008973 catalytic residue [active] 243160008974 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 243160008975 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 243160008976 putative NAD(P) binding site [chemical binding]; other site 243160008977 active site 243160008978 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243160008979 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 243160008980 putative C-terminal domain interface [polypeptide binding]; other site 243160008981 putative GSH binding site (G-site) [chemical binding]; other site 243160008982 putative dimer interface [polypeptide binding]; other site 243160008983 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 243160008984 putative N-terminal domain interface [polypeptide binding]; other site 243160008985 putative dimer interface [polypeptide binding]; other site 243160008986 putative substrate binding pocket (H-site) [chemical binding]; other site 243160008987 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 243160008988 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243160008989 active site 243160008990 NTP binding site [chemical binding]; other site 243160008991 metal binding triad [ion binding]; metal-binding site 243160008992 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243160008993 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 243160008994 Killing trait; Region: RebB; pfam11747 243160008995 FlgN protein; Region: FlgN; pfam05130 243160008996 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 243160008997 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 243160008998 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 243160008999 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 243160009000 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 243160009001 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 243160009002 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243160009003 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243160009004 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 243160009005 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 243160009006 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 243160009007 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 243160009008 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243160009009 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 243160009010 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243160009011 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 243160009012 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243160009013 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 243160009014 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 243160009015 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243160009016 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243160009017 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 243160009018 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 243160009019 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 243160009020 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 243160009021 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 243160009022 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 243160009023 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 243160009024 Flagellar regulator YcgR; Region: YcgR; pfam07317 243160009025 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 243160009026 PilZ domain; Region: PilZ; pfam07238 243160009027 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 243160009028 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243160009029 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 243160009030 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243160009031 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 243160009032 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 243160009033 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 243160009034 PhnA protein; Region: PhnA; pfam03831 243160009035 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 243160009036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160009037 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160009038 trimer interface [polypeptide binding]; other site 243160009039 eyelet of channel; other site 243160009040 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 243160009041 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 243160009042 ligand binding site; other site 243160009043 HTH-like domain; Region: HTH_21; pfam13276 243160009044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009045 Integrase core domain; Region: rve; pfam00665 243160009046 Integrase core domain; Region: rve_3; pfam13683 243160009047 Transposase; Region: HTH_Tnp_1; pfam01527 243160009048 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 243160009049 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243160009050 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243160009051 Transposase domain (DUF772); Region: DUF772; pfam05598 243160009052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160009053 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160009054 glutathione reductase; Validated; Region: PRK06116 243160009055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160009056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160009057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243160009058 argininosuccinate synthase; Validated; Region: PRK05370 243160009059 argininosuccinate synthase; Provisional; Region: PRK13820 243160009060 YHS domain; Region: YHS; pfam04945 243160009061 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243160009062 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243160009063 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243160009064 LemA family; Region: LemA; pfam04011 243160009065 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 243160009066 Repair protein; Region: Repair_PSII; pfam04536 243160009067 Repair protein; Region: Repair_PSII; pfam04536 243160009068 HlyD family secretion protein; Region: HlyD_2; pfam12700 243160009069 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160009070 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 243160009071 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243160009072 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 243160009073 Avidin family; Region: Avidin; pfam01382 243160009074 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243160009075 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243160009076 glutaminase active site [active] 243160009077 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243160009078 dimer interface [polypeptide binding]; other site 243160009079 active site 243160009080 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243160009081 dimer interface [polypeptide binding]; other site 243160009082 active site 243160009083 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 243160009084 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243160009085 Substrate binding site; other site 243160009086 Mg++ binding site; other site 243160009087 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 243160009088 active site 243160009089 substrate binding site [chemical binding]; other site 243160009090 CoA binding site [chemical binding]; other site 243160009091 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 243160009092 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 243160009093 Ligand Binding Site [chemical binding]; other site 243160009094 Dihydroneopterin aldolase; Region: FolB; smart00905 243160009095 active site 243160009096 short chain dehydrogenase; Provisional; Region: PRK09134 243160009097 Uncharacterized conserved protein [Function unknown]; Region: COG1565 243160009098 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 243160009099 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 243160009100 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243160009101 putative substrate binding site [chemical binding]; other site 243160009102 putative ATP binding site [chemical binding]; other site 243160009103 dimerization interface [polypeptide binding]; other site 243160009104 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 243160009105 putative active cleft [active] 243160009106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243160009107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243160009108 DNA binding site [nucleotide binding] 243160009109 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 243160009110 ligand binding site [chemical binding]; other site 243160009111 dimerization interface [polypeptide binding]; other site 243160009112 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243160009113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160009114 dimer interface [polypeptide binding]; other site 243160009115 putative CheW interface [polypeptide binding]; other site 243160009116 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 243160009117 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 243160009118 Transposase; Region: HTH_Tnp_1; pfam01527 243160009119 HTH-like domain; Region: HTH_21; pfam13276 243160009120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009121 Integrase core domain; Region: rve; pfam00665 243160009122 Integrase core domain; Region: rve_3; pfam13683 243160009123 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 243160009124 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243160009125 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243160009126 G1 box; other site 243160009127 GTP/Mg2+ binding site [chemical binding]; other site 243160009128 Switch I region; other site 243160009129 G2 box; other site 243160009130 Switch II region; other site 243160009131 G3 box; other site 243160009132 G4 box; other site 243160009133 G5 box; other site 243160009134 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243160009135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160009136 sequence-specific DNA binding site [nucleotide binding]; other site 243160009137 salt bridge; other site 243160009138 membrane protein insertase; Provisional; Region: PRK01318 243160009139 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 243160009140 hypothetical protein; Validated; Region: PRK00041 243160009141 Ribonuclease P; Region: Ribonuclease_P; cl00457 243160009142 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 243160009143 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 243160009144 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243160009145 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243160009146 active site 243160009147 Int/Topo IB signature motif; other site 243160009148 catalytic residues [active] 243160009149 DNA binding site [nucleotide binding] 243160009150 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 243160009151 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243160009152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160009153 non-specific DNA binding site [nucleotide binding]; other site 243160009154 salt bridge; other site 243160009155 sequence-specific DNA binding site [nucleotide binding]; other site 243160009156 Cupin domain; Region: Cupin_2; pfam07883 243160009157 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243160009158 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 243160009159 substrate-cofactor binding pocket; other site 243160009160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160009161 catalytic residue [active] 243160009162 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 243160009163 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243160009164 NAD(P) binding site [chemical binding]; other site 243160009165 Uncharacterized conserved protein [Function unknown]; Region: COG2353 243160009166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160009167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160009168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 243160009169 SnoaL-like domain; Region: SnoaL_2; pfam12680 243160009170 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 243160009171 putative active site [active] 243160009172 Zn binding site [ion binding]; other site 243160009173 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 243160009174 tartrate dehydrogenase; Region: TTC; TIGR02089 243160009175 transcriptional activator TtdR; Provisional; Region: PRK09801 243160009176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009177 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 243160009178 putative effector binding pocket; other site 243160009179 putative dimerization interface [polypeptide binding]; other site 243160009180 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 243160009181 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243160009182 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 243160009183 putative C-terminal domain interface [polypeptide binding]; other site 243160009184 putative GSH binding site (G-site) [chemical binding]; other site 243160009185 putative dimer interface [polypeptide binding]; other site 243160009186 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 243160009187 putative N-terminal domain interface [polypeptide binding]; other site 243160009188 putative dimer interface [polypeptide binding]; other site 243160009189 putative substrate binding pocket (H-site) [chemical binding]; other site 243160009190 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 243160009191 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243160009192 nucleophile elbow; other site 243160009193 Patatin phospholipase; Region: DUF3734; pfam12536 243160009194 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 243160009195 classical (c) SDRs; Region: SDR_c; cd05233 243160009196 NAD(P) binding site [chemical binding]; other site 243160009197 active site 243160009198 acetoacetate decarboxylase; Provisional; Region: PRK02265 243160009199 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243160009200 active site 243160009201 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 243160009202 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 243160009203 FAD binding pocket [chemical binding]; other site 243160009204 FAD binding motif [chemical binding]; other site 243160009205 phosphate binding motif [ion binding]; other site 243160009206 NAD binding pocket [chemical binding]; other site 243160009207 Predicted transcriptional regulators [Transcription]; Region: COG1695 243160009208 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 243160009209 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243160009210 Cytochrome P450; Region: p450; cl12078 243160009211 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 243160009212 Protein of unknown function (DUF692); Region: DUF692; cl01263 243160009213 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243160009214 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243160009215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160009216 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243160009217 FeS/SAM binding site; other site 243160009218 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160009219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160009220 S-adenosylmethionine binding site [chemical binding]; other site 243160009221 Lysine efflux permease [General function prediction only]; Region: COG1279 243160009222 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 243160009223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160009225 dimerization interface [polypeptide binding]; other site 243160009226 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 243160009227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160009228 ligand binding site [chemical binding]; other site 243160009229 flexible hinge region; other site 243160009230 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243160009231 putative switch regulator; other site 243160009232 non-specific DNA interactions [nucleotide binding]; other site 243160009233 DNA binding site [nucleotide binding] 243160009234 sequence specific DNA binding site [nucleotide binding]; other site 243160009235 putative cAMP binding site [chemical binding]; other site 243160009236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160009237 Ligand Binding Site [chemical binding]; other site 243160009238 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 243160009239 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 243160009240 dimer interface [polypeptide binding]; other site 243160009241 NADP binding site [chemical binding]; other site 243160009242 catalytic residues [active] 243160009243 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 243160009244 Strictosidine synthase; Region: Str_synth; pfam03088 243160009245 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 243160009246 Transcriptional activator HlyU; Region: HlyU; cl02273 243160009247 serine O-acetyltransferase; Region: cysE; TIGR01172 243160009248 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243160009249 trimer interface [polypeptide binding]; other site 243160009250 active site 243160009251 substrate binding site [chemical binding]; other site 243160009252 CoA binding site [chemical binding]; other site 243160009253 short chain dehydrogenase; Provisional; Region: PRK09134 243160009254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160009255 NAD(P) binding site [chemical binding]; other site 243160009256 active site 243160009257 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 243160009258 GTP cyclohydrolase I; Provisional; Region: PLN03044 243160009259 active site 243160009260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160009261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009262 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 243160009263 substrate binding pocket [chemical binding]; other site 243160009264 dimerization interface [polypeptide binding]; other site 243160009265 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 243160009266 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243160009267 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 243160009268 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 243160009269 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 243160009270 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 243160009271 tetramer interface [polypeptide binding]; other site 243160009272 active site 243160009273 benzoate transport; Region: 2A0115; TIGR00895 243160009274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160009275 putative substrate translocation pore; other site 243160009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160009277 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160009278 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 243160009279 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 243160009280 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 243160009281 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 243160009282 RNA polymerase sigma factor; Provisional; Region: PRK11922 243160009283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160009284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160009285 DNA binding residues [nucleotide binding] 243160009286 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 243160009287 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243160009288 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243160009289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160009290 Walker A/P-loop; other site 243160009291 ATP binding site [chemical binding]; other site 243160009292 Q-loop/lid; other site 243160009293 ABC transporter signature motif; other site 243160009294 Walker B; other site 243160009295 D-loop; other site 243160009296 H-loop/switch region; other site 243160009297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160009298 Walker A/P-loop; other site 243160009299 ATP binding site [chemical binding]; other site 243160009300 Q-loop/lid; other site 243160009301 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243160009302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160009303 Walker A/P-loop; other site 243160009304 ATP binding site [chemical binding]; other site 243160009305 Q-loop/lid; other site 243160009306 ABC transporter signature motif; other site 243160009307 Walker B; other site 243160009308 D-loop; other site 243160009309 H-loop/switch region; other site 243160009310 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 243160009311 H-NS histone family; Region: Histone_HNS; pfam00816 243160009312 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160009313 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 243160009314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160009315 putative substrate translocation pore; other site 243160009316 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160009317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160009318 active site 243160009319 phosphorylation site [posttranslational modification] 243160009320 intermolecular recognition site; other site 243160009321 dimerization interface [polypeptide binding]; other site 243160009322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160009323 Walker A motif; other site 243160009324 ATP binding site [chemical binding]; other site 243160009325 Walker B motif; other site 243160009326 arginine finger; other site 243160009327 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160009328 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243160009329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160009330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160009331 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 243160009332 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243160009333 Domain of unknown function (DUF756); Region: DUF756; pfam05506 243160009334 Domain of unknown function (DUF756); Region: DUF756; pfam05506 243160009335 Transposase; Region: HTH_Tnp_1; pfam01527 243160009336 HTH-like domain; Region: HTH_21; pfam13276 243160009337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009338 Integrase core domain; Region: rve; pfam00665 243160009339 Integrase core domain; Region: rve_3; pfam13683 243160009340 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160009341 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 243160009342 Chain length determinant protein; Region: Wzz; pfam02706 243160009343 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243160009344 Phospholipid methyltransferase; Region: PEMT; cl17370 243160009345 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 243160009346 peptidase domain interface [polypeptide binding]; other site 243160009347 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 243160009348 active site 243160009349 catalytic triad [active] 243160009350 calcium binding site [ion binding]; other site 243160009351 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 243160009352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160009353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160009354 metal binding site [ion binding]; metal-binding site 243160009355 active site 243160009356 I-site; other site 243160009357 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160009358 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243160009359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243160009360 short chain dehydrogenase; Provisional; Region: PRK06181 243160009361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160009362 NAD(P) binding site [chemical binding]; other site 243160009363 active site 243160009364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160009365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160009366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009367 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160009368 putative effector binding pocket; other site 243160009369 dimerization interface [polypeptide binding]; other site 243160009370 HTH-like domain; Region: HTH_21; pfam13276 243160009371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009372 Integrase core domain; Region: rve; pfam00665 243160009373 Integrase core domain; Region: rve_3; pfam13683 243160009374 Transposase; Region: HTH_Tnp_1; pfam01527 243160009375 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 243160009376 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243160009377 putative C-terminal domain interface [polypeptide binding]; other site 243160009378 putative GSH binding site (G-site) [chemical binding]; other site 243160009379 putative dimer interface [polypeptide binding]; other site 243160009380 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243160009381 N-terminal domain interface [polypeptide binding]; other site 243160009382 dimer interface [polypeptide binding]; other site 243160009383 substrate binding pocket (H-site) [chemical binding]; other site 243160009384 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243160009385 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 243160009386 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 243160009387 Nucleoside recognition; Region: Gate; pfam07670 243160009388 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 243160009389 deoxyribose-phosphate aldolase; Provisional; Region: PRK05283 243160009390 catalytic residue [active] 243160009391 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 243160009392 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243160009393 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243160009394 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 243160009395 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 243160009396 active site 243160009397 catalytic motif [active] 243160009398 Zn binding site [ion binding]; other site 243160009399 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243160009400 BON domain; Region: BON; pfam04972 243160009401 BON domain; Region: BON; pfam04972 243160009402 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 243160009403 putative substrate binding site [chemical binding]; other site 243160009404 putative ATP binding site [chemical binding]; other site 243160009405 acetate kinase; Provisional; Region: PRK07058 243160009406 propionate/acetate kinase; Provisional; Region: PRK12379 243160009407 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 243160009408 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 243160009409 dimer interaction site [polypeptide binding]; other site 243160009410 substrate-binding tunnel; other site 243160009411 active site 243160009412 catalytic site [active] 243160009413 substrate binding site [chemical binding]; other site 243160009414 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 243160009415 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 243160009416 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 243160009417 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 243160009418 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 243160009419 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243160009420 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243160009421 alpha subunit interaction interface [polypeptide binding]; other site 243160009422 Walker A motif; other site 243160009423 ATP binding site [chemical binding]; other site 243160009424 Walker B motif; other site 243160009425 inhibitor binding site; inhibition site 243160009426 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243160009427 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 243160009428 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243160009429 gamma subunit interface [polypeptide binding]; other site 243160009430 epsilon subunit interface [polypeptide binding]; other site 243160009431 LBP interface [polypeptide binding]; other site 243160009432 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 243160009433 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 243160009434 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 243160009435 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 243160009436 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243160009437 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 243160009438 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243160009439 Walker A motif; other site 243160009440 ATP binding site [chemical binding]; other site 243160009441 Walker B motif; other site 243160009442 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243160009443 ATP synthase; Region: ATP-synt; pfam00231 243160009444 core domain interface [polypeptide binding]; other site 243160009445 delta subunit interface [polypeptide binding]; other site 243160009446 epsilon subunit interface [polypeptide binding]; other site 243160009447 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243160009448 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 243160009449 NAD binding site [chemical binding]; other site 243160009450 substrate binding site [chemical binding]; other site 243160009451 catalytic Zn binding site [ion binding]; other site 243160009452 tetramer interface [polypeptide binding]; other site 243160009453 structural Zn binding site [ion binding]; other site 243160009454 Cache domain; Region: Cache_2; cl07034 243160009455 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243160009456 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160009457 dimer interface [polypeptide binding]; other site 243160009458 putative CheW interface [polypeptide binding]; other site 243160009459 PAS fold; Region: PAS_4; pfam08448 243160009460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160009461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160009462 dimer interface [polypeptide binding]; other site 243160009463 phosphorylation site [posttranslational modification] 243160009464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160009465 ATP binding site [chemical binding]; other site 243160009466 Mg2+ binding site [ion binding]; other site 243160009467 G-X-G motif; other site 243160009468 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243160009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160009470 active site 243160009471 phosphorylation site [posttranslational modification] 243160009472 intermolecular recognition site; other site 243160009473 dimerization interface [polypeptide binding]; other site 243160009474 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 243160009475 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160009476 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243160009477 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243160009478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243160009479 Walker A/P-loop; other site 243160009480 ATP binding site [chemical binding]; other site 243160009481 Q-loop/lid; other site 243160009482 ABC transporter signature motif; other site 243160009483 Walker B; other site 243160009484 D-loop; other site 243160009485 H-loop/switch region; other site 243160009486 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243160009487 Walker A/P-loop; other site 243160009488 ATP binding site [chemical binding]; other site 243160009489 Q-loop/lid; other site 243160009490 ABC transporter signature motif; other site 243160009491 Walker B; other site 243160009492 D-loop; other site 243160009493 H-loop/switch region; other site 243160009494 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243160009495 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243160009496 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160009497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160009498 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160009499 Ligand Binding Site [chemical binding]; other site 243160009500 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243160009501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243160009502 FtsX-like permease family; Region: FtsX; pfam02687 243160009503 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243160009504 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243160009505 Walker A/P-loop; other site 243160009506 ATP binding site [chemical binding]; other site 243160009507 Q-loop/lid; other site 243160009508 ABC transporter signature motif; other site 243160009509 Walker B; other site 243160009510 D-loop; other site 243160009511 H-loop/switch region; other site 243160009512 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 243160009513 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160009514 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 243160009515 putative active site [active] 243160009516 putative metal binding site [ion binding]; other site 243160009517 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243160009518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243160009519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160009520 dimer interface [polypeptide binding]; other site 243160009521 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 243160009522 putative CheW interface [polypeptide binding]; other site 243160009523 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243160009524 ligand-binding site [chemical binding]; other site 243160009525 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 243160009526 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 243160009527 BON domain; Region: BON; pfam04972 243160009528 BON domain; Region: BON; pfam04972 243160009529 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243160009530 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 243160009531 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 243160009532 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243160009533 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 243160009534 putative NAD(P) binding site [chemical binding]; other site 243160009535 putative substrate binding site [chemical binding]; other site 243160009536 catalytic Zn binding site [ion binding]; other site 243160009537 structural Zn binding site [ion binding]; other site 243160009538 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 243160009539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160009540 ligand binding site [chemical binding]; other site 243160009541 flexible hinge region; other site 243160009542 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243160009543 putative switch regulator; other site 243160009544 non-specific DNA interactions [nucleotide binding]; other site 243160009545 DNA binding site [nucleotide binding] 243160009546 sequence specific DNA binding site [nucleotide binding]; other site 243160009547 putative cAMP binding site [chemical binding]; other site 243160009548 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 243160009549 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243160009550 NAD(P) binding site [chemical binding]; other site 243160009551 homotetramer interface [polypeptide binding]; other site 243160009552 homodimer interface [polypeptide binding]; other site 243160009553 active site 243160009554 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 243160009555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243160009556 Beta-Casp domain; Region: Beta-Casp; smart01027 243160009557 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243160009558 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 243160009559 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 243160009560 Transposase domain (DUF772); Region: DUF772; pfam05598 243160009561 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160009562 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160009563 lysine transporter; Provisional; Region: PRK10836 243160009564 HTH-like domain; Region: HTH_21; pfam13276 243160009565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009566 Integrase core domain; Region: rve; pfam00665 243160009567 Integrase core domain; Region: rve_3; pfam13683 243160009568 Transposase; Region: HTH_Tnp_1; pfam01527 243160009569 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 243160009570 Asp-box motif; other site 243160009571 Isochorismatase family; Region: Isochorismatase; pfam00857 243160009572 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 243160009573 catalytic triad [active] 243160009574 conserved cis-peptide bond; other site 243160009575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160009576 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243160009577 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 243160009578 nucleophilic elbow; other site 243160009579 catalytic triad; other site 243160009580 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 243160009581 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 243160009582 putative NAD(P) binding site [chemical binding]; other site 243160009583 active site 243160009584 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 243160009585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160009586 catalytic loop [active] 243160009587 iron binding site [ion binding]; other site 243160009588 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 243160009589 FAD binding pocket [chemical binding]; other site 243160009590 FAD binding motif [chemical binding]; other site 243160009591 phosphate binding motif [ion binding]; other site 243160009592 beta-alpha-beta structure motif; other site 243160009593 NAD binding pocket [chemical binding]; other site 243160009594 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243160009595 inter-subunit interface; other site 243160009596 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 243160009597 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 243160009598 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 243160009599 putative alpha subunit interface [polypeptide binding]; other site 243160009600 putative active site [active] 243160009601 putative substrate binding site [chemical binding]; other site 243160009602 Fe binding site [ion binding]; other site 243160009603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160009604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009605 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 243160009606 dimerizarion interface [polypeptide binding]; other site 243160009607 CrgA pocket; other site 243160009608 substrate binding pocket [chemical binding]; other site 243160009609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160009610 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160009611 NAD(P) binding site [chemical binding]; other site 243160009612 active site 243160009613 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 243160009614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160009615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160009616 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243160009617 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 243160009618 active site 243160009619 FMN binding site [chemical binding]; other site 243160009620 2,4-decadienoyl-CoA binding site; other site 243160009621 catalytic residue [active] 243160009622 4Fe-4S cluster binding site [ion binding]; other site 243160009623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243160009624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160009625 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 243160009626 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243160009627 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 243160009628 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243160009629 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 243160009630 D-pathway; other site 243160009631 Putative ubiquinol binding site [chemical binding]; other site 243160009632 Low-spin heme (heme b) binding site [chemical binding]; other site 243160009633 Putative water exit pathway; other site 243160009634 Binuclear center (heme o3/CuB) [ion binding]; other site 243160009635 K-pathway; other site 243160009636 Putative proton exit pathway; other site 243160009637 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 243160009638 Subunit I/III interface [polypeptide binding]; other site 243160009639 Subunit III/IV interface [polypeptide binding]; other site 243160009640 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 243160009641 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 243160009642 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 243160009643 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 243160009644 dimer interface [polypeptide binding]; other site 243160009645 active site 243160009646 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 243160009647 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 243160009648 octamer interface [polypeptide binding]; other site 243160009649 active site 243160009650 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 243160009651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160009653 dimerization interface [polypeptide binding]; other site 243160009654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160009655 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 243160009656 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 243160009657 putative alpha subunit interface [polypeptide binding]; other site 243160009658 putative active site [active] 243160009659 putative substrate binding site [chemical binding]; other site 243160009660 Fe binding site [ion binding]; other site 243160009661 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243160009662 inter-subunit interface; other site 243160009663 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 243160009664 [2Fe-2S] cluster binding site [ion binding]; other site 243160009665 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 243160009666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160009667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160009668 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 243160009669 HIT family signature motif; other site 243160009670 catalytic residue [active] 243160009671 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 243160009672 PLD-like domain; Region: PLDc_2; pfam13091 243160009673 putative active site [active] 243160009674 catalytic site [active] 243160009675 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 243160009676 PLD-like domain; Region: PLDc_2; pfam13091 243160009677 putative active site [active] 243160009678 catalytic site [active] 243160009679 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243160009680 acetolactate synthase; Reviewed; Region: PRK08322 243160009681 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160009682 PYR/PP interface [polypeptide binding]; other site 243160009683 dimer interface [polypeptide binding]; other site 243160009684 TPP binding site [chemical binding]; other site 243160009685 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160009686 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 243160009687 TPP-binding site [chemical binding]; other site 243160009688 dimer interface [polypeptide binding]; other site 243160009689 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 243160009690 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160009691 NAD(P) binding site [chemical binding]; other site 243160009692 catalytic residues [active] 243160009693 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243160009694 active site 243160009695 catalytic site [active] 243160009696 Response regulator receiver domain; Region: Response_reg; pfam00072 243160009697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160009698 active site 243160009699 phosphorylation site [posttranslational modification] 243160009700 intermolecular recognition site; other site 243160009701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160009702 dimerization interface [polypeptide binding]; other site 243160009703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160009704 dimer interface [polypeptide binding]; other site 243160009705 phosphorylation site [posttranslational modification] 243160009706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160009707 ATP binding site [chemical binding]; other site 243160009708 Mg2+ binding site [ion binding]; other site 243160009709 G-X-G motif; other site 243160009710 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243160009711 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243160009712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160009713 dimerization interface [polypeptide binding]; other site 243160009714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160009715 dimer interface [polypeptide binding]; other site 243160009716 putative CheW interface [polypeptide binding]; other site 243160009717 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 243160009718 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243160009719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160009720 S-adenosylmethionine binding site [chemical binding]; other site 243160009721 TPR repeat; Region: TPR_11; pfam13414 243160009722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243160009723 binding surface 243160009724 TPR motif; other site 243160009725 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 243160009726 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243160009727 putative binding surface; other site 243160009728 active site 243160009729 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 243160009730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160009731 ATP binding site [chemical binding]; other site 243160009732 Mg2+ binding site [ion binding]; other site 243160009733 G-X-G motif; other site 243160009734 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 243160009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160009736 Response regulator receiver domain; Region: Response_reg; pfam00072 243160009737 active site 243160009738 phosphorylation site [posttranslational modification] 243160009739 intermolecular recognition site; other site 243160009740 dimerization interface [polypeptide binding]; other site 243160009741 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 243160009742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160009743 active site 243160009744 phosphorylation site [posttranslational modification] 243160009745 intermolecular recognition site; other site 243160009746 CheB methylesterase; Region: CheB_methylest; pfam01339 243160009747 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 243160009748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160009749 motif II; other site 243160009750 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 243160009751 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243160009752 Cl- selectivity filter; other site 243160009753 Cl- binding residues [ion binding]; other site 243160009754 pore gating glutamate residue; other site 243160009755 dimer interface [polypeptide binding]; other site 243160009756 CAAX protease self-immunity; Region: Abi; pfam02517 243160009757 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 243160009758 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 243160009759 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243160009760 active site 243160009761 HIGH motif; other site 243160009762 dimer interface [polypeptide binding]; other site 243160009763 KMSKS motif; other site 243160009764 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 243160009765 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160009766 conserved cys residue [active] 243160009767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160009768 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243160009769 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 243160009770 conserved cys residue [active] 243160009771 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243160009772 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243160009773 Walker A/P-loop; other site 243160009774 ATP binding site [chemical binding]; other site 243160009775 Q-loop/lid; other site 243160009776 ABC transporter signature motif; other site 243160009777 Walker B; other site 243160009778 D-loop; other site 243160009779 H-loop/switch region; other site 243160009780 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 243160009781 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 243160009782 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 243160009783 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 243160009784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160009785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009786 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 243160009787 substrate binding pocket [chemical binding]; other site 243160009788 dimerization interface [polypeptide binding]; other site 243160009789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160009790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160009791 active site 243160009792 Phosphotransferase enzyme family; Region: APH; pfam01636 243160009793 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243160009794 putative active site [active] 243160009795 putative substrate binding site [chemical binding]; other site 243160009796 ATP binding site [chemical binding]; other site 243160009797 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243160009798 catalytic core [active] 243160009799 short chain dehydrogenase; Provisional; Region: PRK07035 243160009800 classical (c) SDRs; Region: SDR_c; cd05233 243160009801 NAD(P) binding site [chemical binding]; other site 243160009802 active site 243160009803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160009804 short chain dehydrogenase; Validated; Region: PRK07069 243160009805 NAD(P) binding site [chemical binding]; other site 243160009806 active site 243160009807 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 243160009808 Prostaglandin dehydrogenases; Region: PGDH; cd05288 243160009809 NAD(P) binding site [chemical binding]; other site 243160009810 substrate binding site [chemical binding]; other site 243160009811 dimer interface [polypeptide binding]; other site 243160009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160009813 putative substrate translocation pore; other site 243160009814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160009815 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 243160009816 N-terminal plug; other site 243160009817 ligand-binding site [chemical binding]; other site 243160009818 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243160009819 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243160009820 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 243160009821 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 243160009822 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 243160009823 generic binding surface I; other site 243160009824 generic binding surface II; other site 243160009825 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 243160009826 putative active site [active] 243160009827 putative catalytic site [active] 243160009828 putative Mg binding site IVb [ion binding]; other site 243160009829 putative phosphate binding site [ion binding]; other site 243160009830 putative DNA binding site [nucleotide binding]; other site 243160009831 putative Mg binding site IVa [ion binding]; other site 243160009832 YCII-related domain; Region: YCII; cl00999 243160009833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 243160009834 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 243160009835 putative hydrophobic ligand binding site [chemical binding]; other site 243160009836 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 243160009837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160009838 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243160009839 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243160009840 amidase catalytic site [active] 243160009841 Zn binding residues [ion binding]; other site 243160009842 substrate binding site [chemical binding]; other site 243160009843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243160009844 Rubrerythrin [Energy production and conversion]; Region: COG1592 243160009845 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 243160009846 binuclear metal center [ion binding]; other site 243160009847 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243160009848 Cysteine-rich domain; Region: CCG; pfam02754 243160009849 Cysteine-rich domain; Region: CCG; pfam02754 243160009850 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 243160009851 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 243160009852 CoA-binding domain; Region: CoA_binding_3; pfam13727 243160009853 Bacterial sugar transferase; Region: Bac_transf; cl00939 243160009854 Transposase; Region: HTH_Tnp_1; pfam01527 243160009855 HTH-like domain; Region: HTH_21; pfam13276 243160009856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160009857 Integrase core domain; Region: rve; pfam00665 243160009858 Integrase core domain; Region: rve_3; pfam13683 243160009859 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160009860 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160009861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160009862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160009863 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160009864 Homeodomain-like domain; Region: HTH_23; pfam13384 243160009865 Winged helix-turn helix; Region: HTH_29; pfam13551 243160009866 Winged helix-turn helix; Region: HTH_33; pfam13592 243160009867 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243160009868 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 243160009869 phosphate binding site [ion binding]; other site 243160009870 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 243160009871 putative deacylase active site [active] 243160009872 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243160009873 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243160009874 active site 243160009875 catalytic site [active] 243160009876 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243160009877 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243160009878 thiamine phosphate binding site [chemical binding]; other site 243160009879 active site 243160009880 pyrophosphate binding site [ion binding]; other site 243160009881 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243160009882 Domain of unknown function DUF21; Region: DUF21; pfam01595 243160009883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243160009884 Transporter associated domain; Region: CorC_HlyC; smart01091 243160009885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160009886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160009887 dimer interface [polypeptide binding]; other site 243160009888 phosphorylation site [posttranslational modification] 243160009889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 243160009890 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160009891 EamA-like transporter family; Region: EamA; pfam00892 243160009892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160009893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160009894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160009895 dimerization interface [polypeptide binding]; other site 243160009896 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 243160009897 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 243160009898 dimer interface [polypeptide binding]; other site 243160009899 hexamer interface [polypeptide binding]; other site 243160009900 active site 2 [active] 243160009901 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 243160009902 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 243160009903 molybdenum-pterin binding domain; Region: Mop; TIGR00638 243160009904 TOBE domain; Region: TOBE; cl01440 243160009905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160009906 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 243160009907 Walker A/P-loop; other site 243160009908 ATP binding site [chemical binding]; other site 243160009909 Q-loop/lid; other site 243160009910 ABC transporter signature motif; other site 243160009911 Walker B; other site 243160009912 D-loop; other site 243160009913 H-loop/switch region; other site 243160009914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160009915 putative PBP binding loops; other site 243160009916 dimer interface [polypeptide binding]; other site 243160009917 ABC-ATPase subunit interface; other site 243160009918 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243160009919 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243160009920 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 243160009921 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 243160009922 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 243160009923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160009924 MarR family; Region: MarR; pfam01047 243160009925 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 243160009926 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 243160009927 putative active site [active] 243160009928 putative substrate binding site [chemical binding]; other site 243160009929 ATP binding site [chemical binding]; other site 243160009930 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 243160009931 AMP nucleosidase; Provisional; Region: PRK08292 243160009932 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 243160009933 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 243160009934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243160009935 active site 243160009936 Int/Topo IB signature motif; other site 243160009937 DNA binding site [nucleotide binding] 243160009938 Phage-related protein [Function unknown]; Region: COG4695; cl01923 243160009939 Galactose-3-O-sulfotransferase; Region: Gal-3-0_sulfotr; pfam06990 243160009940 Uncharacterized conserved protein [Function unknown]; Region: COG1683 243160009941 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243160009942 DNA polymerase I; Provisional; Region: PRK05755 243160009943 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243160009944 active site 243160009945 metal binding site 1 [ion binding]; metal-binding site 243160009946 putative 5' ssDNA interaction site; other site 243160009947 metal binding site 3; metal-binding site 243160009948 metal binding site 2 [ion binding]; metal-binding site 243160009949 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243160009950 putative DNA binding site [nucleotide binding]; other site 243160009951 putative metal binding site [ion binding]; other site 243160009952 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 243160009953 active site 243160009954 catalytic site [active] 243160009955 substrate binding site [chemical binding]; other site 243160009956 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243160009957 active site 243160009958 DNA binding site [nucleotide binding] 243160009959 catalytic site [active] 243160009960 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243160009961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160009962 Predicted membrane protein [Function unknown]; Region: COG4655 243160009963 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 243160009964 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243160009965 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243160009966 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243160009967 active site residue [active] 243160009968 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 243160009969 active site residue [active] 243160009970 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243160009971 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243160009972 [2Fe-2S] cluster binding site [ion binding]; other site 243160009973 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243160009974 alpha subunit interface [polypeptide binding]; other site 243160009975 active site 243160009976 substrate binding site [chemical binding]; other site 243160009977 Fe binding site [ion binding]; other site 243160009978 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 243160009979 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243160009980 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243160009981 substrate binding pocket [chemical binding]; other site 243160009982 chain length determination region; other site 243160009983 substrate-Mg2+ binding site; other site 243160009984 catalytic residues [active] 243160009985 aspartate-rich region 1; other site 243160009986 active site lid residues [active] 243160009987 aspartate-rich region 2; other site 243160009988 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243160009989 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243160009990 TPP-binding site; other site 243160009991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243160009992 PYR/PP interface [polypeptide binding]; other site 243160009993 dimer interface [polypeptide binding]; other site 243160009994 TPP binding site [chemical binding]; other site 243160009995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243160009996 putative GTP cyclohydrolase; Provisional; Region: PRK13674 243160009997 Transposase domain (DUF772); Region: DUF772; pfam05598 243160009998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160009999 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160010000 UGMP family protein; Validated; Region: PRK09604 243160010001 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243160010002 Predicted flavoproteins [General function prediction only]; Region: COG2081 243160010003 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243160010004 Yqey-like protein; Region: YqeY; pfam09424 243160010005 DNA primase; Validated; Region: dnaG; PRK05667 243160010006 CHC2 zinc finger; Region: zf-CHC2; pfam01807 243160010007 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243160010008 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243160010009 active site 243160010010 metal binding site [ion binding]; metal-binding site 243160010011 interdomain interaction site; other site 243160010012 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 243160010013 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 243160010014 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243160010015 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 243160010016 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243160010017 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 243160010018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160010019 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243160010020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160010021 DNA binding residues [nucleotide binding] 243160010022 HTH-like domain; Region: HTH_21; pfam13276 243160010023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010024 Integrase core domain; Region: rve; pfam00665 243160010025 Integrase core domain; Region: rve_3; pfam13683 243160010026 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 243160010027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010028 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 243160010029 substrate binding pocket [chemical binding]; other site 243160010030 dimerization interface [polypeptide binding]; other site 243160010031 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 243160010032 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 243160010033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010034 putative substrate translocation pore; other site 243160010035 POT family; Region: PTR2; cl17359 243160010036 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 243160010037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160010038 non-specific DNA binding site [nucleotide binding]; other site 243160010039 salt bridge; other site 243160010040 sequence-specific DNA binding site [nucleotide binding]; other site 243160010041 Cupin domain; Region: Cupin_2; pfam07883 243160010042 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 243160010043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 243160010044 peptide binding site [polypeptide binding]; other site 243160010045 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 243160010046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160010047 dimer interface [polypeptide binding]; other site 243160010048 conserved gate region; other site 243160010049 putative PBP binding loops; other site 243160010050 ABC-ATPase subunit interface; other site 243160010051 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 243160010052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160010053 dimer interface [polypeptide binding]; other site 243160010054 conserved gate region; other site 243160010055 putative PBP binding loops; other site 243160010056 ABC-ATPase subunit interface; other site 243160010057 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243160010058 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160010059 Walker A/P-loop; other site 243160010060 ATP binding site [chemical binding]; other site 243160010061 Q-loop/lid; other site 243160010062 ABC transporter signature motif; other site 243160010063 Walker B; other site 243160010064 D-loop; other site 243160010065 H-loop/switch region; other site 243160010066 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160010067 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 243160010068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160010069 Walker A/P-loop; other site 243160010070 ATP binding site [chemical binding]; other site 243160010071 Q-loop/lid; other site 243160010072 ABC transporter signature motif; other site 243160010073 Walker B; other site 243160010074 D-loop; other site 243160010075 H-loop/switch region; other site 243160010076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160010077 outer membrane porin, OprD family; Region: OprD; pfam03573 243160010078 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243160010079 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243160010080 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 243160010081 active site residue [active] 243160010082 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 243160010083 PAS fold; Region: PAS_4; pfam08448 243160010084 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160010085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160010086 Walker B motif; other site 243160010087 arginine finger; other site 243160010088 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160010089 H-NS histone family; Region: Histone_HNS; pfam00816 243160010090 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160010091 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 243160010092 CoA binding domain; Region: CoA_binding_2; pfam13380 243160010093 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 243160010094 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 243160010095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243160010096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160010097 Coenzyme A binding pocket [chemical binding]; other site 243160010098 indole acetimide hydrolase; Validated; Region: PRK07488 243160010099 Amidase; Region: Amidase; pfam01425 243160010100 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160010101 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243160010102 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160010103 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243160010104 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243160010105 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 243160010106 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243160010107 phosphate binding site [ion binding]; other site 243160010108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160010110 dimerization interface [polypeptide binding]; other site 243160010111 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160010112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010113 putative substrate translocation pore; other site 243160010114 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243160010115 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243160010116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160010117 catalytic residue [active] 243160010118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160010120 putative substrate translocation pore; other site 243160010121 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243160010122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160010123 dimerization interface [polypeptide binding]; other site 243160010124 putative DNA binding site [nucleotide binding]; other site 243160010125 putative Zn2+ binding site [ion binding]; other site 243160010126 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243160010127 active site residue [active] 243160010128 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160010129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160010131 dimerization interface [polypeptide binding]; other site 243160010132 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160010133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010134 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 243160010135 dimerization interface [polypeptide binding]; other site 243160010136 substrate binding pocket [chemical binding]; other site 243160010137 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243160010138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160010139 NAD(P) binding site [chemical binding]; other site 243160010140 active site 243160010141 hypothetical protein; Provisional; Region: PRK07538 243160010142 hypothetical protein; Provisional; Region: PRK07236 243160010143 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 243160010144 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243160010145 phosphopeptide binding site; other site 243160010146 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 243160010147 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 243160010148 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 243160010149 hypothetical protein; Provisional; Region: PRK07033 243160010150 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 243160010151 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160010152 ligand binding site [chemical binding]; other site 243160010153 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 243160010154 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 243160010155 G1 box; other site 243160010156 GTP/Mg2+ binding site [chemical binding]; other site 243160010157 G2 box; other site 243160010158 G3 box; other site 243160010159 Switch II region; other site 243160010160 G4 box; other site 243160010161 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 243160010162 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 243160010163 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 243160010164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243160010165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243160010166 active site 243160010167 ATP binding site [chemical binding]; other site 243160010168 substrate binding site [chemical binding]; other site 243160010169 activation loop (A-loop); other site 243160010170 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 243160010171 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 243160010172 Protein of unknown function (DUF770); Region: DUF770; pfam05591 243160010173 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 243160010174 Protein of unknown function (DUF877); Region: DUF877; pfam05943 243160010175 Protein of unknown function (DUF796); Region: DUF796; pfam05638 243160010176 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 243160010177 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 243160010178 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 243160010179 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 243160010180 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 243160010181 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 243160010182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160010183 Walker A motif; other site 243160010184 ATP binding site [chemical binding]; other site 243160010185 Walker B motif; other site 243160010186 arginine finger; other site 243160010187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160010188 Walker A motif; other site 243160010189 ATP binding site [chemical binding]; other site 243160010190 Walker B motif; other site 243160010191 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243160010192 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243160010193 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160010194 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160010195 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 243160010196 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243160010197 RHS Repeat; Region: RHS_repeat; cl11982 243160010198 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 243160010199 RHS Repeat; Region: RHS_repeat; cl11982 243160010200 RHS Repeat; Region: RHS_repeat; cl11982 243160010201 RHS Repeat; Region: RHS_repeat; cl11982 243160010202 RHS Repeat; Region: RHS_repeat; cl11982 243160010203 HTH-like domain; Region: HTH_21; pfam13276 243160010204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010205 Integrase core domain; Region: rve; pfam00665 243160010206 Integrase core domain; Region: rve_3; pfam13683 243160010207 Transposase; Region: HTH_Tnp_1; pfam01527 243160010208 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160010209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160010210 S-adenosylmethionine binding site [chemical binding]; other site 243160010211 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160010212 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243160010213 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 243160010214 NAD-dependent deacetylase; Provisional; Region: PRK05333 243160010215 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 243160010216 Protein of unknown function (DUF938); Region: DUF938; pfam06080 243160010217 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243160010218 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 243160010219 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 243160010220 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 243160010221 Cupin domain; Region: Cupin_2; cl17218 243160010222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243160010223 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160010224 E3 interaction surface; other site 243160010225 lipoyl attachment site [posttranslational modification]; other site 243160010226 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 243160010227 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 243160010228 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 243160010229 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160010230 N-terminal plug; other site 243160010231 ligand-binding site [chemical binding]; other site 243160010232 lipase chaperone; Provisional; Region: PRK01294 243160010233 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 243160010234 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160010235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160010236 DNA-binding site [nucleotide binding]; DNA binding site 243160010237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160010238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160010239 homodimer interface [polypeptide binding]; other site 243160010240 catalytic residue [active] 243160010241 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243160010242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160010243 Walker A/P-loop; other site 243160010244 ATP binding site [chemical binding]; other site 243160010245 Q-loop/lid; other site 243160010246 ABC transporter signature motif; other site 243160010247 Walker B; other site 243160010248 D-loop; other site 243160010249 H-loop/switch region; other site 243160010250 TOBE domain; Region: TOBE_2; pfam08402 243160010251 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 243160010252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243160010253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160010254 dimer interface [polypeptide binding]; other site 243160010255 conserved gate region; other site 243160010256 putative PBP binding loops; other site 243160010257 ABC-ATPase subunit interface; other site 243160010258 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243160010259 catalytic residues [active] 243160010260 HTH-like domain; Region: HTH_21; pfam13276 243160010261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010262 Integrase core domain; Region: rve; pfam00665 243160010263 Integrase core domain; Region: rve_3; pfam13683 243160010264 Transposase; Region: HTH_Tnp_1; pfam01527 243160010265 Protein of unknown function (DUF770); Region: DUF770; cl01402 243160010266 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 243160010267 Protein of unknown function (DUF877); Region: DUF877; pfam05943 243160010268 Protein of unknown function (DUF796); Region: DUF796; pfam05638 243160010269 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 243160010270 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 243160010271 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 243160010272 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 243160010273 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243160010274 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160010275 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160010276 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243160010277 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160010278 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160010279 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 243160010280 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243160010281 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243160010282 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243160010283 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 243160010284 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160010285 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 243160010286 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 243160010287 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 243160010288 hypothetical protein; Provisional; Region: PRK14693 243160010289 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 243160010290 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160010291 ligand binding site [chemical binding]; other site 243160010292 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 243160010293 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 243160010294 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 243160010295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160010296 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243160010297 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243160010298 active site 243160010299 TDP-binding site; other site 243160010300 acceptor substrate-binding pocket; other site 243160010301 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160010302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010303 putative substrate translocation pore; other site 243160010304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010305 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 243160010306 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 243160010307 Ligand binding site; other site 243160010308 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160010309 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 243160010310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160010311 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160010312 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 243160010313 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 243160010314 substrate binding [chemical binding]; other site 243160010315 active site 243160010316 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 243160010317 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 243160010318 active site 243160010319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243160010320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243160010321 DNA binding site [nucleotide binding] 243160010322 domain linker motif; other site 243160010323 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 243160010324 ligand binding site [chemical binding]; other site 243160010325 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 243160010326 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 243160010327 NAD binding site [chemical binding]; other site 243160010328 catalytic Zn binding site [ion binding]; other site 243160010329 structural Zn binding site [ion binding]; other site 243160010330 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160010331 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 243160010332 conserved cys residue [active] 243160010333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160010334 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 243160010335 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243160010336 dimer interface [polypeptide binding]; other site 243160010337 active site 243160010338 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243160010339 folate binding site [chemical binding]; other site 243160010340 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 243160010341 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 243160010342 active site 243160010343 dimer interface [polypeptide binding]; other site 243160010344 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 243160010345 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 243160010346 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 243160010347 putative active site [active] 243160010348 putative FMN binding site [chemical binding]; other site 243160010349 putative substrate binding site [chemical binding]; other site 243160010350 putative catalytic residue [active] 243160010351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243160010352 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 243160010353 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243160010354 Cysteine-rich domain; Region: CCG; pfam02754 243160010355 Cysteine-rich domain; Region: CCG; pfam02754 243160010356 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 243160010357 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 243160010358 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 243160010359 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243160010360 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243160010361 [2Fe-2S] cluster binding site [ion binding]; other site 243160010362 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 243160010363 putative alpha subunit interface [polypeptide binding]; other site 243160010364 putative active site [active] 243160010365 putative substrate binding site [chemical binding]; other site 243160010366 Fe binding site [ion binding]; other site 243160010367 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243160010368 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 243160010369 FAD binding pocket [chemical binding]; other site 243160010370 FAD binding motif [chemical binding]; other site 243160010371 phosphate binding motif [ion binding]; other site 243160010372 beta-alpha-beta structure motif; other site 243160010373 NAD binding pocket [chemical binding]; other site 243160010374 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243160010375 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160010376 catalytic loop [active] 243160010377 iron binding site [ion binding]; other site 243160010378 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 243160010379 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 243160010380 Amino acid permease; Region: AA_permease_2; pfam13520 243160010381 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 243160010382 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243160010383 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 243160010384 putative active site [active] 243160010385 putative substrate binding site [chemical binding]; other site 243160010386 putative cosubstrate binding site; other site 243160010387 catalytic site [active] 243160010388 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 243160010389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010390 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 243160010391 substrate binding pocket [chemical binding]; other site 243160010392 dimerization interface [polypeptide binding]; other site 243160010393 choline-sulfatase; Region: chol_sulfatase; TIGR03417 243160010394 Sulfatase; Region: Sulfatase; cl17466 243160010395 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 243160010396 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 243160010397 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 243160010398 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160010399 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160010400 trimer interface [polypeptide binding]; other site 243160010401 eyelet of channel; other site 243160010402 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 243160010403 Peptidase family M28; Region: Peptidase_M28; pfam04389 243160010404 active site 243160010405 metal binding site [ion binding]; metal-binding site 243160010406 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 243160010407 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 243160010408 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 243160010409 Zn binding site [ion binding]; other site 243160010410 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160010411 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 243160010412 conserved cys residue [active] 243160010413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160010414 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 243160010415 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 243160010416 Uncharacterized conserved protein [Function unknown]; Region: COG3246 243160010417 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 243160010418 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243160010419 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243160010420 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243160010421 active site 243160010422 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243160010423 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 243160010424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160010425 HTH-like domain; Region: HTH_21; pfam13276 243160010426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010427 Integrase core domain; Region: rve; pfam00665 243160010428 Integrase core domain; Region: rve_3; pfam13683 243160010429 Transposase; Region: HTH_Tnp_1; pfam01527 243160010430 amino acid transporter; Region: 2A0306; TIGR00909 243160010431 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 243160010432 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 243160010433 putative active site [active] 243160010434 metal binding site [ion binding]; metal-binding site 243160010435 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 243160010436 Flavoprotein; Region: Flavoprotein; pfam02441 243160010437 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 243160010438 putative GSH binding site [chemical binding]; other site 243160010439 catalytic residues [active] 243160010440 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 243160010441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160010442 S-adenosylmethionine binding site [chemical binding]; other site 243160010443 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243160010444 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243160010445 RF-1 domain; Region: RF-1; pfam00472 243160010446 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 243160010447 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243160010448 tRNA; other site 243160010449 putative tRNA binding site [nucleotide binding]; other site 243160010450 putative NADP binding site [chemical binding]; other site 243160010451 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 243160010452 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243160010453 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243160010454 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 243160010455 active site 243160010456 Isochorismatase family; Region: Isochorismatase; pfam00857 243160010457 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 243160010458 catalytic triad [active] 243160010459 conserved cis-peptide bond; other site 243160010460 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 243160010461 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 243160010462 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243160010463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160010464 Walker A/P-loop; other site 243160010465 ATP binding site [chemical binding]; other site 243160010466 Q-loop/lid; other site 243160010467 ABC transporter signature motif; other site 243160010468 Walker B; other site 243160010469 D-loop; other site 243160010470 H-loop/switch region; other site 243160010471 ABC transporter; Region: ABC_tran_2; pfam12848 243160010472 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243160010473 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 243160010474 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243160010475 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 243160010476 active site 243160010477 catalytic site [active] 243160010478 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 243160010479 Helix-turn-helix domain; Region: HTH_18; pfam12833 243160010480 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243160010481 GTP-binding protein YchF; Reviewed; Region: PRK09601 243160010482 YchF GTPase; Region: YchF; cd01900 243160010483 G1 box; other site 243160010484 GTP/Mg2+ binding site [chemical binding]; other site 243160010485 Switch I region; other site 243160010486 G2 box; other site 243160010487 Switch II region; other site 243160010488 G3 box; other site 243160010489 G4 box; other site 243160010490 G5 box; other site 243160010491 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243160010492 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 243160010493 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 243160010494 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 243160010495 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 243160010496 dimerization domain [polypeptide binding]; other site 243160010497 dimer interface [polypeptide binding]; other site 243160010498 catalytic residues [active] 243160010499 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 243160010500 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 243160010501 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243160010502 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243160010503 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160010504 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 243160010505 ligand binding site [chemical binding]; other site 243160010506 active site 243160010507 UGI interface [polypeptide binding]; other site 243160010508 catalytic site [active] 243160010509 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 243160010510 putative active site [active] 243160010511 putative metal binding residues [ion binding]; other site 243160010512 signature motif; other site 243160010513 putative triphosphate binding site [ion binding]; other site 243160010514 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243160010515 active site 243160010516 ribulose/triose binding site [chemical binding]; other site 243160010517 phosphate binding site [ion binding]; other site 243160010518 substrate (anthranilate) binding pocket [chemical binding]; other site 243160010519 product (indole) binding pocket [chemical binding]; other site 243160010520 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243160010521 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243160010522 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243160010523 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 243160010524 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243160010525 glutamine binding [chemical binding]; other site 243160010526 catalytic triad [active] 243160010527 anthranilate synthase component I; Provisional; Region: PRK13565 243160010528 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243160010529 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243160010530 phosphoglycolate phosphatase; Provisional; Region: PRK13222 243160010531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160010532 motif II; other site 243160010533 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243160010534 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 243160010535 substrate binding site [chemical binding]; other site 243160010536 hexamer interface [polypeptide binding]; other site 243160010537 metal binding site [ion binding]; metal-binding site 243160010538 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 243160010539 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 243160010540 MltA specific insert domain; Region: MltA; smart00925 243160010541 3D domain; Region: 3D; pfam06725 243160010542 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 243160010543 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 243160010544 active site 243160010545 AMP binding site [chemical binding]; other site 243160010546 homodimer interface [polypeptide binding]; other site 243160010547 acyl-activating enzyme (AAE) consensus motif; other site 243160010548 CoA binding site [chemical binding]; other site 243160010549 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160010550 CoenzymeA binding site [chemical binding]; other site 243160010551 subunit interaction site [polypeptide binding]; other site 243160010552 PHB binding site; other site 243160010553 enoyl-CoA hydratase; Provisional; Region: PRK08140 243160010554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160010555 substrate binding site [chemical binding]; other site 243160010556 oxyanion hole (OAH) forming residues; other site 243160010557 trimer interface [polypeptide binding]; other site 243160010558 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 243160010559 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160010560 dimer interface [polypeptide binding]; other site 243160010561 active site 243160010562 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 243160010563 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160010564 NAD(P) binding site [chemical binding]; other site 243160010565 catalytic residues [active] 243160010566 enoyl-CoA hydratase; Provisional; Region: PRK05862 243160010567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160010568 substrate binding site [chemical binding]; other site 243160010569 oxyanion hole (OAH) forming residues; other site 243160010570 trimer interface [polypeptide binding]; other site 243160010571 Transposase; Region: HTH_Tnp_1; pfam01527 243160010572 HTH-like domain; Region: HTH_21; pfam13276 243160010573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010574 Integrase core domain; Region: rve; pfam00665 243160010575 Integrase core domain; Region: rve_3; pfam13683 243160010576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160010577 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160010578 active site 243160010579 metal binding site [ion binding]; metal-binding site 243160010580 HTH-like domain; Region: HTH_21; pfam13276 243160010581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010582 Integrase core domain; Region: rve; pfam00665 243160010583 Integrase core domain; Region: rve_3; pfam13683 243160010584 Transposase; Region: HTH_Tnp_1; pfam01527 243160010585 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 243160010586 arsenical-resistance protein; Region: acr3; TIGR00832 243160010587 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 243160010588 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243160010589 active site 243160010590 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 243160010591 putative metal binding site [ion binding]; other site 243160010592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160010593 dimerization interface [polypeptide binding]; other site 243160010594 putative DNA binding site [nucleotide binding]; other site 243160010595 putative Zn2+ binding site [ion binding]; other site 243160010596 Predicted flavoprotein [General function prediction only]; Region: COG0431 243160010597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160010598 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 243160010599 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 243160010600 Walker A/P-loop; other site 243160010601 ATP binding site [chemical binding]; other site 243160010602 Q-loop/lid; other site 243160010603 ABC transporter signature motif; other site 243160010604 Walker B; other site 243160010605 D-loop; other site 243160010606 H-loop/switch region; other site 243160010607 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243160010608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160010609 dimer interface [polypeptide binding]; other site 243160010610 conserved gate region; other site 243160010611 putative PBP binding loops; other site 243160010612 ABC-ATPase subunit interface; other site 243160010613 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160010614 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 243160010615 conserved cys residue [active] 243160010616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160010617 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 243160010618 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 243160010619 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 243160010620 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 243160010621 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160010622 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 243160010623 putative NAD(P) binding site [chemical binding]; other site 243160010624 active site 243160010625 putative substrate binding site [chemical binding]; other site 243160010626 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 243160010627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010628 D-galactonate transporter; Region: 2A0114; TIGR00893 243160010629 putative substrate translocation pore; other site 243160010630 putative aldolase; Validated; Region: PRK08130 243160010631 intersubunit interface [polypeptide binding]; other site 243160010632 active site 243160010633 Zn2+ binding site [ion binding]; other site 243160010634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 243160010635 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243160010636 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243160010637 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243160010638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160010639 DNA-binding site [nucleotide binding]; DNA binding site 243160010640 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 243160010641 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 243160010642 Cupin domain; Region: Cupin_2; cl17218 243160010643 Transposase; Region: HTH_Tnp_1; pfam01527 243160010644 HTH-like domain; Region: HTH_21; pfam13276 243160010645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010646 Integrase core domain; Region: rve; pfam00665 243160010647 Integrase core domain; Region: rve_3; pfam13683 243160010648 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160010649 Secretory lipase; Region: LIP; pfam03583 243160010650 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160010651 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160010652 trimer interface [polypeptide binding]; other site 243160010653 eyelet of channel; other site 243160010654 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 243160010655 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 243160010656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160010657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160010658 DNA binding residues [nucleotide binding] 243160010659 dimerization interface [polypeptide binding]; other site 243160010660 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243160010661 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 243160010662 homodimer interface [polypeptide binding]; other site 243160010663 homotetramer interface [polypeptide binding]; other site 243160010664 active site pocket [active] 243160010665 cleavage site 243160010666 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 243160010667 Fusaric acid resistance protein family; Region: FUSC; pfam04632 243160010668 transcriptional regulator; Provisional; Region: PRK10632 243160010669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160010670 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160010671 putative effector binding pocket; other site 243160010672 dimerization interface [polypeptide binding]; other site 243160010673 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 243160010674 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160010675 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160010676 trimer interface [polypeptide binding]; other site 243160010677 eyelet of channel; other site 243160010678 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 243160010679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160010680 cytosine permease; Provisional; Region: codB; PRK11017 243160010681 Na binding site [ion binding]; other site 243160010682 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 243160010683 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 243160010684 cytosine deaminase; Provisional; Region: PRK09230 243160010685 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 243160010686 active site 243160010687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010688 putative substrate translocation pore; other site 243160010689 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 243160010690 short chain dehydrogenase; Provisional; Region: PRK12829 243160010691 classical (c) SDRs; Region: SDR_c; cd05233 243160010692 NAD(P) binding site [chemical binding]; other site 243160010693 active site 243160010694 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243160010695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 243160010696 FCD domain; Region: FCD; pfam07729 243160010697 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 243160010698 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243160010699 putative ion selectivity filter; other site 243160010700 putative pore gating glutamate residue; other site 243160010701 H-type lectin domain; Region: H_lectin; pfam09458 243160010702 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243160010703 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243160010704 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243160010705 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243160010706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243160010707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160010708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 243160010709 active site 243160010710 phosphorylation site [posttranslational modification] 243160010711 intermolecular recognition site; other site 243160010712 dimerization interface [polypeptide binding]; other site 243160010713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160010714 DNA binding residues [nucleotide binding] 243160010715 dimerization interface [polypeptide binding]; other site 243160010716 MarR family; Region: MarR_2; cl17246 243160010717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160010718 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243160010719 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 243160010720 Uncharacterized conserved protein [Function unknown]; Region: COG5649 243160010721 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 243160010722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160010723 substrate binding site [chemical binding]; other site 243160010724 oxyanion hole (OAH) forming residues; other site 243160010725 trimer interface [polypeptide binding]; other site 243160010726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160010727 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160010728 NAD(P) binding site [chemical binding]; other site 243160010729 catalytic residues [active] 243160010730 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 243160010731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160010732 putative substrate translocation pore; other site 243160010733 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160010734 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160010735 trimer interface [polypeptide binding]; other site 243160010736 eyelet of channel; other site 243160010737 Tannase and feruloyl esterase; Region: Tannase; pfam07519 243160010738 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160010739 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243160010740 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160010741 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 243160010742 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243160010743 ligand binding site [chemical binding]; other site 243160010744 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243160010745 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243160010746 Walker A/P-loop; other site 243160010747 ATP binding site [chemical binding]; other site 243160010748 Q-loop/lid; other site 243160010749 ABC transporter signature motif; other site 243160010750 Walker B; other site 243160010751 D-loop; other site 243160010752 H-loop/switch region; other site 243160010753 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243160010754 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160010755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160010756 TM-ABC transporter signature motif; other site 243160010757 Amidohydrolase; Region: Amidohydro_2; pfam04909 243160010758 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 243160010759 active site 243160010760 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243160010761 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 243160010762 NAD binding site [chemical binding]; other site 243160010763 homotetramer interface [polypeptide binding]; other site 243160010764 homodimer interface [polypeptide binding]; other site 243160010765 active site 243160010766 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243160010767 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243160010768 short chain dehydrogenase; Provisional; Region: PRK08628 243160010769 classical (c) SDRs; Region: SDR_c; cd05233 243160010770 NAD(P) binding site [chemical binding]; other site 243160010771 active site 243160010772 Domain of unknown function (DUF718); Region: DUF718; cl01281 243160010773 HTH-like domain; Region: HTH_21; pfam13276 243160010774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010775 Integrase core domain; Region: rve; pfam00665 243160010776 Integrase core domain; Region: rve_3; pfam13683 243160010777 Transposase; Region: HTH_Tnp_1; pfam01527 243160010778 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160010779 trimer interface [polypeptide binding]; other site 243160010780 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160010781 YadA-like C-terminal region; Region: YadA; pfam03895 243160010782 H-NS histone family; Region: Histone_HNS; pfam00816 243160010783 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160010784 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243160010785 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160010786 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160010787 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160010788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160010789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160010790 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160010791 CoenzymeA binding site [chemical binding]; other site 243160010792 subunit interaction site [polypeptide binding]; other site 243160010793 PHB binding site; other site 243160010794 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 243160010795 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 243160010796 dimerization interface [polypeptide binding]; other site 243160010797 ligand binding site [chemical binding]; other site 243160010798 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 243160010799 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 243160010800 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 243160010801 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 243160010802 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 243160010803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160010804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160010805 metal binding site [ion binding]; metal-binding site 243160010806 active site 243160010807 I-site; other site 243160010808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160010809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160010810 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243160010811 AsnC family; Region: AsnC_trans_reg; pfam01037 243160010812 aromatic amino acid transporter; Provisional; Region: PRK10238 243160010813 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 243160010814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160010815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160010816 homodimer interface [polypeptide binding]; other site 243160010817 catalytic residue [active] 243160010818 Protein of unknown function, DUF488; Region: DUF488; cl01246 243160010819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243160010820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160010821 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 243160010822 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 243160010823 PAS fold; Region: PAS; pfam00989 243160010824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160010825 putative active site [active] 243160010826 heme pocket [chemical binding]; other site 243160010827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160010828 ATP binding site [chemical binding]; other site 243160010829 G-X-G motif; other site 243160010830 Response regulator receiver domain; Region: Response_reg; pfam00072 243160010831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160010832 active site 243160010833 phosphorylation site [posttranslational modification] 243160010834 intermolecular recognition site; other site 243160010835 dimerization interface [polypeptide binding]; other site 243160010836 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 243160010837 Transglycosylase; Region: Transgly; pfam00912 243160010838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243160010839 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 243160010840 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 243160010841 MG2 domain; Region: A2M_N; pfam01835 243160010842 Alpha-2-macroglobulin family; Region: A2M; pfam00207 243160010843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 243160010844 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243160010845 putative active site pocket [active] 243160010846 dimerization interface [polypeptide binding]; other site 243160010847 putative catalytic residue [active] 243160010848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160010849 S-adenosylmethionine binding site [chemical binding]; other site 243160010850 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 243160010851 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243160010852 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 243160010853 substrate binding pocket [chemical binding]; other site 243160010854 active site 243160010855 iron coordination sites [ion binding]; other site 243160010856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160010857 S-adenosylmethionine binding site [chemical binding]; other site 243160010858 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243160010859 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160010860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160010861 catalytic residue [active] 243160010862 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 243160010863 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 243160010864 putative monooxygenase; Reviewed; Region: PRK07045 243160010865 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243160010866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 243160010867 sequence-specific DNA binding site [nucleotide binding]; other site 243160010868 salt bridge; other site 243160010869 Cupin domain; Region: Cupin_2; pfam07883 243160010870 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 243160010871 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 243160010872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160010873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160010874 active site 243160010875 phosphorylation site [posttranslational modification] 243160010876 intermolecular recognition site; other site 243160010877 dimerization interface [polypeptide binding]; other site 243160010878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160010879 DNA binding residues [nucleotide binding] 243160010880 dimerization interface [polypeptide binding]; other site 243160010881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010882 Ligand Binding Site [chemical binding]; other site 243160010883 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010884 Ligand Binding Site [chemical binding]; other site 243160010885 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010886 Ligand Binding Site [chemical binding]; other site 243160010887 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010888 Ligand Binding Site [chemical binding]; other site 243160010889 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010890 Ligand Binding Site [chemical binding]; other site 243160010891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160010892 Ligand Binding Site [chemical binding]; other site 243160010893 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 243160010894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243160010895 catalytic Zn binding site [ion binding]; other site 243160010896 structural Zn binding site [ion binding]; other site 243160010897 NAD(P) binding site [chemical binding]; other site 243160010898 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243160010899 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243160010900 active site residue [active] 243160010901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160010902 NAD(P) binding site [chemical binding]; other site 243160010903 active site 243160010904 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 243160010905 Spore germination protein; Region: Spore_permease; cl17796 243160010906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160010907 sequence-specific DNA binding site [nucleotide binding]; other site 243160010908 salt bridge; other site 243160010909 H-NS histone family; Region: Histone_HNS; pfam00816 243160010910 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160010911 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 243160010912 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 243160010913 Flavin binding site [chemical binding]; other site 243160010914 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 243160010915 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 243160010916 HTH-like domain; Region: HTH_21; pfam13276 243160010917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160010918 Integrase core domain; Region: rve; pfam00665 243160010919 Integrase core domain; Region: rve_3; pfam13683 243160010920 Transposase; Region: HTH_Tnp_1; pfam01527 243160010921 GTP cyclohydrolase I; Reviewed; Region: PRK12606 243160010922 GTP cyclohydrolase I; Provisional; Region: PLN03044 243160010923 active site 243160010924 Bacterial Ig-like domain; Region: Big_5; pfam13205 243160010925 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 243160010926 active site 243160010927 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 243160010928 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 243160010929 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 243160010930 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 243160010931 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 243160010932 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 243160010933 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 243160010934 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 243160010935 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 243160010936 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160010937 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160010938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160010939 Walker A motif; other site 243160010940 ATP binding site [chemical binding]; other site 243160010941 Walker B motif; other site 243160010942 arginine finger; other site 243160010943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160010944 Walker A motif; other site 243160010945 ATP binding site [chemical binding]; other site 243160010946 Walker B motif; other site 243160010947 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243160010948 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 243160010949 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 243160010950 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 243160010951 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 243160010952 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 243160010953 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 243160010954 Protein of unknown function (DUF877); Region: DUF877; pfam05943 243160010955 Protein of unknown function (DUF770); Region: DUF770; pfam05591 243160010956 MASE1; Region: MASE1; cl17823 243160010957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160010958 dimer interface [polypeptide binding]; other site 243160010959 phosphorylation site [posttranslational modification] 243160010960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160010961 ATP binding site [chemical binding]; other site 243160010962 G-X-G motif; other site 243160010963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160010964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160010965 active site 243160010966 phosphorylation site [posttranslational modification] 243160010967 intermolecular recognition site; other site 243160010968 dimerization interface [polypeptide binding]; other site 243160010969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160010970 DNA binding site [nucleotide binding] 243160010971 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 243160010972 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 243160010973 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160010974 trimer interface [polypeptide binding]; other site 243160010975 Haemagglutinin; Region: HIM; pfam05662 243160010976 YadA-like C-terminal region; Region: YadA; pfam03895 243160010977 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 243160010978 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243160010979 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243160010980 amidase catalytic site [active] 243160010981 Zn binding residues [ion binding]; other site 243160010982 substrate binding site [chemical binding]; other site 243160010983 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243160010984 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 243160010985 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243160010986 Cu(I) binding site [ion binding]; other site 243160010987 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243160010988 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243160010989 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 243160010990 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243160010991 Multicopper oxidase; Region: Cu-oxidase; pfam00394 243160010992 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160010993 Cytochrome c; Region: Cytochrom_C; pfam00034 243160010994 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243160010995 putative hydrophobic ligand binding site [chemical binding]; other site 243160010996 protein interface [polypeptide binding]; other site 243160010997 gate; other site 243160010998 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 243160010999 hypothetical protein; Provisional; Region: PRK02399 243160011000 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 243160011001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160011002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160011003 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243160011004 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 243160011005 homodimer interface [polypeptide binding]; other site 243160011006 NAD binding pocket [chemical binding]; other site 243160011007 ATP binding pocket [chemical binding]; other site 243160011008 Mg binding site [ion binding]; other site 243160011009 active-site loop [active] 243160011010 putative oxidoreductase; Provisional; Region: PRK10083 243160011011 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 243160011012 putative NAD(P) binding site [chemical binding]; other site 243160011013 catalytic Zn binding site [ion binding]; other site 243160011014 structural Zn binding site [ion binding]; other site 243160011015 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 243160011016 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 243160011017 metal binding site [ion binding]; metal-binding site 243160011018 substrate binding pocket [chemical binding]; other site 243160011019 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243160011020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160011021 DNA-binding site [nucleotide binding]; DNA binding site 243160011022 FCD domain; Region: FCD; pfam07729 243160011023 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243160011024 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243160011025 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243160011026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011027 D-galactonate transporter; Region: 2A0114; TIGR00893 243160011028 putative substrate translocation pore; other site 243160011029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011030 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 243160011031 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 243160011032 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 243160011033 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243160011034 putative active site [active] 243160011035 catalytic site [active] 243160011036 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 243160011037 putative active site [active] 243160011038 catalytic site [active] 243160011039 PLD-like domain; Region: PLDc_2; pfam13091 243160011040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160011041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160011042 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 243160011043 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 243160011044 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160011045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160011046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160011047 dimerization interface [polypeptide binding]; other site 243160011048 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 243160011049 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160011050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160011051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160011052 homodimer interface [polypeptide binding]; other site 243160011053 catalytic residue [active] 243160011054 aldehyde dehydrogenase family 7 member; Region: PLN02315 243160011055 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 243160011056 tetrameric interface [polypeptide binding]; other site 243160011057 NAD binding site [chemical binding]; other site 243160011058 catalytic residues [active] 243160011059 ApbE family; Region: ApbE; pfam02424 243160011060 ApbE family; Region: ApbE; pfam02424 243160011061 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 243160011062 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 243160011063 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 243160011064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160011065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011066 active site 243160011067 phosphorylation site [posttranslational modification] 243160011068 intermolecular recognition site; other site 243160011069 dimerization interface [polypeptide binding]; other site 243160011070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011071 DNA binding site [nucleotide binding] 243160011072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160011073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243160011074 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 243160011075 dimer interface [polypeptide binding]; other site 243160011076 phosphorylation site [posttranslational modification] 243160011077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011078 ATP binding site [chemical binding]; other site 243160011079 Mg2+ binding site [ion binding]; other site 243160011080 G-X-G motif; other site 243160011081 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 243160011082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160011083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160011084 benzoate transport; Region: 2A0115; TIGR00895 243160011085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011087 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 243160011088 Cupin-like domain; Region: Cupin_8; pfam13621 243160011089 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 243160011090 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243160011091 [2Fe-2S] cluster binding site [ion binding]; other site 243160011092 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243160011093 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243160011094 alpha subunit interface [polypeptide binding]; other site 243160011095 active site 243160011096 substrate binding site [chemical binding]; other site 243160011097 Fe binding site [ion binding]; other site 243160011098 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 243160011099 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 243160011100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160011101 catalytic residue [active] 243160011102 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243160011103 Multicopper oxidase; Region: Cu-oxidase; pfam00394 243160011104 Cytochrome c; Region: Cytochrom_C; pfam00034 243160011105 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 243160011106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160011107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160011108 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 243160011109 isovaleryl-CoA dehydrogenase; Region: PLN02519 243160011110 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 243160011111 substrate binding site [chemical binding]; other site 243160011112 FAD binding site [chemical binding]; other site 243160011113 catalytic base [active] 243160011114 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 243160011115 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243160011116 enoyl-CoA hydratase; Provisional; Region: PRK05995 243160011117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160011118 substrate binding site [chemical binding]; other site 243160011119 oxyanion hole (OAH) forming residues; other site 243160011120 trimer interface [polypeptide binding]; other site 243160011121 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 243160011122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243160011123 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243160011124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243160011125 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243160011126 carboxyltransferase (CT) interaction site; other site 243160011127 biotinylation site [posttranslational modification]; other site 243160011128 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 243160011129 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 243160011130 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 243160011131 Haemagglutinin; Region: HIM; pfam05662 243160011132 YadA-like C-terminal region; Region: YadA; pfam03895 243160011133 HTH-like domain; Region: HTH_21; pfam13276 243160011134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011135 Integrase core domain; Region: rve; pfam00665 243160011136 Integrase core domain; Region: rve_3; pfam13683 243160011137 Transposase; Region: HTH_Tnp_1; pfam01527 243160011138 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 243160011139 glutaminase; Provisional; Region: PRK00971 243160011140 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 243160011141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011142 active site 243160011143 phosphorylation site [posttranslational modification] 243160011144 intermolecular recognition site; other site 243160011145 dimerization interface [polypeptide binding]; other site 243160011146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011147 DNA binding site [nucleotide binding] 243160011148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011149 dimer interface [polypeptide binding]; other site 243160011150 phosphorylation site [posttranslational modification] 243160011151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011152 ATP binding site [chemical binding]; other site 243160011153 Mg2+ binding site [ion binding]; other site 243160011154 G-X-G motif; other site 243160011155 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243160011156 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 243160011157 active site 243160011158 nucleophile elbow; other site 243160011159 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243160011160 Surface antigen; Region: Bac_surface_Ag; pfam01103 243160011161 rod shape-determining protein MreB; Provisional; Region: PRK13930 243160011162 MreB and similar proteins; Region: MreB_like; cd10225 243160011163 nucleotide binding site [chemical binding]; other site 243160011164 Mg binding site [ion binding]; other site 243160011165 putative protofilament interaction site [polypeptide binding]; other site 243160011166 RodZ interaction site [polypeptide binding]; other site 243160011167 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160011168 Cytochrome c; Region: Cytochrom_C; cl11414 243160011169 HD domain; Region: HD_3; pfam13023 243160011170 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 243160011171 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 243160011172 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 243160011173 putative dimer interface [polypeptide binding]; other site 243160011174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160011175 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243160011176 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 243160011177 C-terminal domain interface [polypeptide binding]; other site 243160011178 GSH binding site (G-site) [chemical binding]; other site 243160011179 dimer interface [polypeptide binding]; other site 243160011180 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 243160011181 N-terminal domain interface [polypeptide binding]; other site 243160011182 dimer interface [polypeptide binding]; other site 243160011183 substrate binding pocket (H-site) [chemical binding]; other site 243160011184 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 243160011185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011186 dimer interface [polypeptide binding]; other site 243160011187 phosphorylation site [posttranslational modification] 243160011188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011189 ATP binding site [chemical binding]; other site 243160011190 Mg2+ binding site [ion binding]; other site 243160011191 G-X-G motif; other site 243160011192 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 243160011193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011194 active site 243160011195 phosphorylation site [posttranslational modification] 243160011196 intermolecular recognition site; other site 243160011197 dimerization interface [polypeptide binding]; other site 243160011198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011199 DNA binding site [nucleotide binding] 243160011200 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160011201 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160011202 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160011203 putative active site [active] 243160011204 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 243160011205 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243160011206 active site residue [active] 243160011207 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 243160011208 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 243160011209 conserved cys residue [active] 243160011210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160011211 hypothetical protein; Provisional; Region: PRK07907 243160011212 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 243160011213 metal binding site [ion binding]; metal-binding site 243160011214 putative dimer interface [polypeptide binding]; other site 243160011215 TfoX N-terminal domain; Region: TfoX_N; pfam04993 243160011216 NnrU protein; Region: NnrU; pfam07298 243160011217 HTH-like domain; Region: HTH_21; pfam13276 243160011218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011219 Integrase core domain; Region: rve; pfam00665 243160011220 Integrase core domain; Region: rve_3; pfam13683 243160011221 Transposase; Region: HTH_Tnp_1; pfam01527 243160011222 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243160011223 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243160011224 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 243160011225 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 243160011226 dimer interface [polypeptide binding]; other site 243160011227 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 243160011228 active site 243160011229 Fe binding site [ion binding]; other site 243160011230 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243160011231 Dehydroquinase class II; Region: DHquinase_II; pfam01220 243160011232 active site 243160011233 trimer interface [polypeptide binding]; other site 243160011234 dimer interface [polypeptide binding]; other site 243160011235 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 243160011236 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243160011237 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243160011238 shikimate binding site; other site 243160011239 NAD(P) binding site [chemical binding]; other site 243160011240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011241 D-galactonate transporter; Region: 2A0114; TIGR00893 243160011242 putative substrate translocation pore; other site 243160011243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011244 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 243160011245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160011246 catalytic residue [active] 243160011247 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243160011248 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160011249 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 243160011250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160011251 Walker A/P-loop; other site 243160011252 ATP binding site [chemical binding]; other site 243160011253 Q-loop/lid; other site 243160011254 ABC transporter signature motif; other site 243160011255 Walker B; other site 243160011256 D-loop; other site 243160011257 H-loop/switch region; other site 243160011258 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 243160011259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160011260 dimer interface [polypeptide binding]; other site 243160011261 conserved gate region; other site 243160011262 putative PBP binding loops; other site 243160011263 ABC-ATPase subunit interface; other site 243160011264 2-aminoethylphosphonate ABC transport system, membrane component PhnV; Region: PhnV; TIGR03255 243160011265 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 243160011266 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 243160011267 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 243160011268 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 243160011269 NAD(P) binding site [chemical binding]; other site 243160011270 catalytic residues [active] 243160011271 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 243160011272 HTH-like domain; Region: HTH_21; pfam13276 243160011273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011274 Integrase core domain; Region: rve; pfam00665 243160011275 Integrase core domain; Region: rve_3; pfam13683 243160011276 Transposase; Region: HTH_Tnp_1; pfam01527 243160011277 Transposase domain (DUF772); Region: DUF772; pfam05598 243160011278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160011279 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160011280 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 243160011281 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 243160011282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243160011283 active site 243160011284 catalytic tetrad [active] 243160011285 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 243160011286 classical (c) SDRs; Region: SDR_c; cd05233 243160011287 NAD(P) binding site [chemical binding]; other site 243160011288 active site 243160011289 Transposase domain (DUF772); Region: DUF772; pfam05598 243160011290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160011291 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160011292 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 243160011293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160011294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160011295 homodimer interface [polypeptide binding]; other site 243160011296 catalytic residue [active] 243160011297 excinuclease ABC subunit B; Provisional; Region: PRK05298 243160011298 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 243160011299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160011300 ATP-binding site [chemical binding]; other site 243160011301 ATP binding site [chemical binding]; other site 243160011302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160011303 nucleotide binding region [chemical binding]; other site 243160011304 ATP-binding site [chemical binding]; other site 243160011305 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243160011306 UvrB/uvrC motif; Region: UVR; pfam02151 243160011307 Fe2+ transport protein; Region: Iron_transport; pfam10634 243160011308 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 243160011309 Iron permease FTR1 family; Region: FTR1; cl00475 243160011310 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 243160011311 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243160011312 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 243160011313 Transposase; Region: HTH_Tnp_1; pfam01527 243160011314 HTH-like domain; Region: HTH_21; pfam13276 243160011315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011316 Integrase core domain; Region: rve; pfam00665 243160011317 Integrase core domain; Region: rve_3; pfam13683 243160011318 Bacitracin resistance protein BacA; Region: BacA; cl00858 243160011319 HTH-like domain; Region: HTH_21; pfam13276 243160011320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011321 Integrase core domain; Region: rve; pfam00665 243160011322 Integrase core domain; Region: rve_3; pfam13683 243160011323 Transposase; Region: HTH_Tnp_1; pfam01527 243160011324 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 243160011325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160011326 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 243160011327 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243160011328 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 243160011329 active site 243160011330 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243160011331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243160011332 DNA-binding site [nucleotide binding]; DNA binding site 243160011333 RNA-binding motif; other site 243160011334 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243160011335 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 243160011336 putative ligand binding site [chemical binding]; other site 243160011337 NAD binding site [chemical binding]; other site 243160011338 catalytic site [active] 243160011339 OsmC-like protein; Region: OsmC; cl00767 243160011340 CHASE3 domain; Region: CHASE3; pfam05227 243160011341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160011342 PAS domain; Region: PAS_9; pfam13426 243160011343 putative active site [active] 243160011344 heme pocket [chemical binding]; other site 243160011345 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243160011346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160011347 putative active site [active] 243160011348 heme pocket [chemical binding]; other site 243160011349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011350 dimer interface [polypeptide binding]; other site 243160011351 phosphorylation site [posttranslational modification] 243160011352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011353 ATP binding site [chemical binding]; other site 243160011354 Mg2+ binding site [ion binding]; other site 243160011355 G-X-G motif; other site 243160011356 Response regulator receiver domain; Region: Response_reg; pfam00072 243160011357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011358 active site 243160011359 phosphorylation site [posttranslational modification] 243160011360 intermolecular recognition site; other site 243160011361 dimerization interface [polypeptide binding]; other site 243160011362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011363 Response regulator receiver domain; Region: Response_reg; pfam00072 243160011364 active site 243160011365 phosphorylation site [posttranslational modification] 243160011366 intermolecular recognition site; other site 243160011367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160011368 PAS fold; Region: PAS_3; pfam08447 243160011369 putative active site [active] 243160011370 heme pocket [chemical binding]; other site 243160011371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243160011372 Histidine kinase; Region: HisKA_3; pfam07730 243160011373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011374 ATP binding site [chemical binding]; other site 243160011375 Mg2+ binding site [ion binding]; other site 243160011376 G-X-G motif; other site 243160011377 benzoate transport; Region: 2A0115; TIGR00895 243160011378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011379 putative substrate translocation pore; other site 243160011380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011381 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 243160011382 choline dehydrogenase; Validated; Region: PRK02106 243160011383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160011384 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 243160011385 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160011386 NAD(P) binding site [chemical binding]; other site 243160011387 catalytic residues [active] 243160011388 transcriptional regulator BetI; Validated; Region: PRK00767 243160011389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160011390 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 243160011391 Transposase; Region: HTH_Tnp_1; pfam01527 243160011392 HTH-like domain; Region: HTH_21; pfam13276 243160011393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011394 Integrase core domain; Region: rve; pfam00665 243160011395 Integrase core domain; Region: rve_3; pfam13683 243160011396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160011397 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243160011398 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243160011399 active site 243160011400 TDP-binding site; other site 243160011401 acceptor substrate-binding pocket; other site 243160011402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160011403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011404 putative substrate translocation pore; other site 243160011405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011406 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 243160011407 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 243160011408 Ligand binding site; other site 243160011409 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160011410 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 243160011411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160011412 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160011413 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 243160011414 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243160011415 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 243160011416 active site residue [active] 243160011417 serine O-acetyltransferase; Region: cysE; TIGR01172 243160011418 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243160011419 trimer interface [polypeptide binding]; other site 243160011420 active site 243160011421 substrate binding site [chemical binding]; other site 243160011422 CoA binding site [chemical binding]; other site 243160011423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160011424 non-specific DNA binding site [nucleotide binding]; other site 243160011425 salt bridge; other site 243160011426 sequence-specific DNA binding site [nucleotide binding]; other site 243160011427 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243160011428 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243160011429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160011430 catalytic residue [active] 243160011431 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 243160011432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160011433 dimerization interface [polypeptide binding]; other site 243160011434 putative DNA binding site [nucleotide binding]; other site 243160011435 putative Zn2+ binding site [ion binding]; other site 243160011436 Predicted transporter component [General function prediction only]; Region: COG2391 243160011437 Predicted transporter component [General function prediction only]; Region: COG2391 243160011438 Sulphur transport; Region: Sulf_transp; pfam04143 243160011439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 243160011440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160011441 Coenzyme A binding pocket [chemical binding]; other site 243160011442 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 243160011443 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243160011444 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 243160011445 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243160011446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160011447 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243160011448 active site 243160011449 metal binding site [ion binding]; metal-binding site 243160011450 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 243160011451 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160011452 active site 243160011453 benzoate transport; Region: 2A0115; TIGR00895 243160011454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011455 putative substrate translocation pore; other site 243160011456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243160011457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160011458 DNA-binding site [nucleotide binding]; DNA binding site 243160011459 UTRA domain; Region: UTRA; pfam07702 243160011460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011461 putative substrate translocation pore; other site 243160011462 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 243160011463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160011464 putative DNA binding site [nucleotide binding]; other site 243160011465 putative Zn2+ binding site [ion binding]; other site 243160011466 AsnC family; Region: AsnC_trans_reg; pfam01037 243160011467 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 243160011468 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 243160011469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160011470 catalytic residue [active] 243160011471 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160011472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160011473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160011474 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160011475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160011476 S-adenosylmethionine binding site [chemical binding]; other site 243160011477 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 243160011478 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243160011479 FAD binding domain; Region: FAD_binding_4; pfam01565 243160011480 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 243160011481 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243160011482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160011483 EamA-like transporter family; Region: EamA; pfam00892 243160011484 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243160011485 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160011486 active site 243160011487 HIGH motif; other site 243160011488 nucleotide binding site [chemical binding]; other site 243160011489 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243160011490 active site 243160011491 KMSKS motif; other site 243160011492 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243160011493 tRNA binding surface [nucleotide binding]; other site 243160011494 anticodon binding site; other site 243160011495 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243160011496 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243160011497 Beta-lactamase; Region: Beta-lactamase; pfam00144 243160011498 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243160011499 BCCT family transporter; Region: BCCT; pfam02028 243160011500 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160011501 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160011502 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 243160011503 putative active site [active] 243160011504 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 243160011505 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 243160011506 catalytic nucleophile [active] 243160011507 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 243160011508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160011509 Walker A/P-loop; other site 243160011510 ATP binding site [chemical binding]; other site 243160011511 Q-loop/lid; other site 243160011512 ABC transporter signature motif; other site 243160011513 Walker B; other site 243160011514 D-loop; other site 243160011515 H-loop/switch region; other site 243160011516 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 243160011517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243160011518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160011519 Walker A/P-loop; other site 243160011520 ATP binding site [chemical binding]; other site 243160011521 Q-loop/lid; other site 243160011522 ABC transporter signature motif; other site 243160011523 Walker B; other site 243160011524 D-loop; other site 243160011525 H-loop/switch region; other site 243160011526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160011527 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 243160011528 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 243160011529 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 243160011530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160011531 dimer interface [polypeptide binding]; other site 243160011532 conserved gate region; other site 243160011533 putative PBP binding loops; other site 243160011534 ABC-ATPase subunit interface; other site 243160011535 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 243160011536 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 243160011537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160011538 dimer interface [polypeptide binding]; other site 243160011539 conserved gate region; other site 243160011540 putative PBP binding loops; other site 243160011541 ABC-ATPase subunit interface; other site 243160011542 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 243160011543 SxDxEG motif; other site 243160011544 active site 243160011545 metal binding site [ion binding]; metal-binding site 243160011546 homopentamer interface [polypeptide binding]; other site 243160011547 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 243160011548 active site 243160011549 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 243160011550 heterodimer interface [polypeptide binding]; other site 243160011551 multimer interface [polypeptide binding]; other site 243160011552 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 243160011553 active site 243160011554 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 243160011555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160011556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160011557 dimerization interface [polypeptide binding]; other site 243160011558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160011559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160011560 metal binding site [ion binding]; metal-binding site 243160011561 active site 243160011562 I-site; other site 243160011563 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 243160011564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160011565 S-adenosylmethionine binding site [chemical binding]; other site 243160011566 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 243160011567 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243160011568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 243160011569 putative transporter; Provisional; Region: PRK11021 243160011570 Transposase; Region: HTH_Tnp_1; pfam01527 243160011571 HTH-like domain; Region: HTH_21; pfam13276 243160011572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011573 Integrase core domain; Region: rve; pfam00665 243160011574 Integrase core domain; Region: rve_3; pfam13683 243160011575 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 243160011576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243160011577 ATP binding site [chemical binding]; other site 243160011578 putative Mg++ binding site [ion binding]; other site 243160011579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160011580 nucleotide binding region [chemical binding]; other site 243160011581 ATP-binding site [chemical binding]; other site 243160011582 DEAD/H associated; Region: DEAD_assoc; pfam08494 243160011583 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 243160011584 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243160011585 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243160011586 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243160011587 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 243160011588 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 243160011589 putative active site [active] 243160011590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160011591 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 243160011592 Walker A/P-loop; other site 243160011593 ATP binding site [chemical binding]; other site 243160011594 Q-loop/lid; other site 243160011595 ABC transporter signature motif; other site 243160011596 Walker B; other site 243160011597 D-loop; other site 243160011598 H-loop/switch region; other site 243160011599 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 243160011600 putative acyl-acceptor binding pocket; other site 243160011601 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 243160011602 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 243160011603 linker region; other site 243160011604 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160011605 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 243160011606 Transposase; Region: HTH_Tnp_1; pfam01527 243160011607 HTH-like domain; Region: HTH_21; pfam13276 243160011608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011609 Integrase core domain; Region: rve; pfam00665 243160011610 Integrase core domain; Region: rve_3; pfam13683 243160011611 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 243160011612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160011613 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 243160011614 putative Ile/Val binding site [chemical binding]; other site 243160011615 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243160011616 putative Ile/Val binding site [chemical binding]; other site 243160011617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160011618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160011619 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 243160011620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243160011621 EamA-like transporter family; Region: EamA; pfam00892 243160011622 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243160011623 Uncharacterized conserved protein [Function unknown]; Region: COG1739 243160011624 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 243160011625 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 243160011626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160011627 RNA polymerase factor sigma-70; Validated; Region: PRK09047 243160011628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160011629 DNA binding residues [nucleotide binding] 243160011630 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243160011631 acyl-CoA synthetase; Validated; Region: PRK05850 243160011632 acyl-activating enzyme (AAE) consensus motif; other site 243160011633 active site 243160011634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160011635 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243160011636 active site 243160011637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243160011638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243160011639 active site 243160011640 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160011641 Biofilm formation and stress response factor; Region: BsmA; pfam10014 243160011642 Condensation domain; Region: Condensation; pfam00668 243160011643 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243160011644 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243160011645 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160011646 acyl-activating enzyme (AAE) consensus motif; other site 243160011647 AMP binding site [chemical binding]; other site 243160011648 Condensation domain; Region: Condensation; pfam00668 243160011649 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243160011650 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243160011651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160011652 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160011653 acyl-activating enzyme (AAE) consensus motif; other site 243160011654 AMP binding site [chemical binding]; other site 243160011655 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160011656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160011657 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243160011658 active site 243160011659 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243160011660 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243160011661 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243160011662 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243160011663 KR domain; Region: KR; pfam08659 243160011664 putative NADP binding site [chemical binding]; other site 243160011665 active site 243160011666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160011667 HTH-like domain; Region: HTH_21; pfam13276 243160011668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011669 Integrase core domain; Region: rve; pfam00665 243160011670 Integrase core domain; Region: rve_3; pfam13683 243160011671 Transposase; Region: HTH_Tnp_1; pfam01527 243160011672 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 243160011673 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243160011674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160011675 dimerization interface [polypeptide binding]; other site 243160011676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011677 dimer interface [polypeptide binding]; other site 243160011678 phosphorylation site [posttranslational modification] 243160011679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011680 ATP binding site [chemical binding]; other site 243160011681 Mg2+ binding site [ion binding]; other site 243160011682 G-X-G motif; other site 243160011683 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 243160011684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011685 active site 243160011686 phosphorylation site [posttranslational modification] 243160011687 intermolecular recognition site; other site 243160011688 dimerization interface [polypeptide binding]; other site 243160011689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011690 DNA binding site [nucleotide binding] 243160011691 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 243160011692 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160011693 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243160011694 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160011695 Outer membrane efflux protein; Region: OEP; pfam02321 243160011696 Outer membrane efflux protein; Region: OEP; pfam02321 243160011697 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 243160011698 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 243160011699 putative deacylase active site [active] 243160011700 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 243160011701 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243160011702 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243160011703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160011704 Walker A motif; other site 243160011705 ATP binding site [chemical binding]; other site 243160011706 Walker B motif; other site 243160011707 arginine finger; other site 243160011708 Peptidase family M41; Region: Peptidase_M41; pfam01434 243160011709 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243160011710 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160011711 active site 243160011712 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243160011713 Predicted transcriptional regulator [Transcription]; Region: COG2345 243160011714 MarR family; Region: MarR_2; pfam12802 243160011715 Transcriptional regulator PadR-like family; Region: PadR; cl17335 243160011716 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 243160011717 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243160011718 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160011719 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160011720 multidrug efflux protein; Reviewed; Region: PRK09579 243160011721 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 243160011722 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243160011723 dimerization interface [polypeptide binding]; other site 243160011724 active site 243160011725 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243160011726 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 243160011727 structural tetrad; other site 243160011728 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 243160011729 structural tetrad; other site 243160011730 FOG: WD40 repeat [General function prediction only]; Region: COG2319 243160011731 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243160011732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160011733 S-adenosylmethionine binding site [chemical binding]; other site 243160011734 Phage integrase protein; Region: DUF3701; pfam12482 243160011735 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243160011736 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 243160011737 Int/Topo IB signature motif; other site 243160011738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 243160011739 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 243160011740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 243160011741 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 243160011742 HTH-like domain; Region: HTH_21; pfam13276 243160011743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160011744 Integrase core domain; Region: rve; pfam00665 243160011745 Integrase core domain; Region: rve_3; pfam13683 243160011746 Transposase; Region: HTH_Tnp_1; pfam01527 243160011747 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243160011748 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243160011749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243160011750 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 243160011751 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 243160011752 ligand binding site [chemical binding]; other site 243160011753 short chain dehydrogenase; Provisional; Region: PRK07074 243160011754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160011755 NAD(P) binding site [chemical binding]; other site 243160011756 active site 243160011757 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 243160011758 putative cation:proton antiport protein; Provisional; Region: PRK10669 243160011759 TrkA-N domain; Region: TrkA_N; pfam02254 243160011760 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 243160011761 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 243160011762 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243160011763 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 243160011764 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243160011765 dimer interface [polypeptide binding]; other site 243160011766 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 243160011767 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 243160011768 Cl binding site [ion binding]; other site 243160011769 oligomer interface [polypeptide binding]; other site 243160011770 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 243160011771 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 243160011772 Electron transfer DM13; Region: DM13; pfam10517 243160011773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243160011774 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243160011775 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 243160011776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243160011777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160011778 dimer interface [polypeptide binding]; other site 243160011779 conserved gate region; other site 243160011780 putative PBP binding loops; other site 243160011781 ABC-ATPase subunit interface; other site 243160011782 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243160011783 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 243160011784 inhibitor binding site; inhibition site 243160011785 catalytic Zn binding site [ion binding]; other site 243160011786 structural Zn binding site [ion binding]; other site 243160011787 NADP binding site [chemical binding]; other site 243160011788 tetramer interface [polypeptide binding]; other site 243160011789 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243160011790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160011791 Walker A/P-loop; other site 243160011792 ATP binding site [chemical binding]; other site 243160011793 Q-loop/lid; other site 243160011794 ABC transporter signature motif; other site 243160011795 Walker B; other site 243160011796 D-loop; other site 243160011797 H-loop/switch region; other site 243160011798 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160011799 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160011800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160011801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160011802 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 243160011803 N- and C-terminal domain interface [polypeptide binding]; other site 243160011804 D-xylulose kinase; Region: XylB; TIGR01312 243160011805 active site 243160011806 MgATP binding site [chemical binding]; other site 243160011807 catalytic site [active] 243160011808 metal binding site [ion binding]; metal-binding site 243160011809 xylulose binding site [chemical binding]; other site 243160011810 homodimer interface [polypeptide binding]; other site 243160011811 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243160011812 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243160011813 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243160011814 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243160011815 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243160011816 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243160011817 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 243160011818 [4Fe-4S] binding site [ion binding]; other site 243160011819 molybdopterin cofactor binding site; other site 243160011820 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 243160011821 molybdopterin cofactor binding site; other site 243160011822 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 243160011823 Flavodoxin; Region: Flavodoxin_1; pfam00258 243160011824 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 243160011825 FAD binding pocket [chemical binding]; other site 243160011826 FAD binding motif [chemical binding]; other site 243160011827 catalytic residues [active] 243160011828 NAD binding pocket [chemical binding]; other site 243160011829 phosphate binding motif [ion binding]; other site 243160011830 beta-alpha-beta structure motif; other site 243160011831 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 243160011832 nitrite reductase subunit NirD; Provisional; Region: PRK14989 243160011833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160011834 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243160011835 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243160011836 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 243160011837 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243160011838 active site 243160011839 SAM binding site [chemical binding]; other site 243160011840 homodimer interface [polypeptide binding]; other site 243160011841 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243160011842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011843 active site 243160011844 phosphorylation site [posttranslational modification] 243160011845 intermolecular recognition site; other site 243160011846 dimerization interface [polypeptide binding]; other site 243160011847 ANTAR domain; Region: ANTAR; pfam03861 243160011848 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243160011849 NMT1-like family; Region: NMT1_2; pfam13379 243160011850 GTP cyclohydrolase I; Reviewed; Region: PRK12606 243160011851 GTP cyclohydrolase I; Provisional; Region: PLN03044 243160011852 active site 243160011853 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243160011854 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 243160011855 active site 243160011856 Zn binding site [ion binding]; other site 243160011857 allantoate amidohydrolase; Reviewed; Region: PRK12893 243160011858 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 243160011859 active site 243160011860 metal binding site [ion binding]; metal-binding site 243160011861 dimer interface [polypeptide binding]; other site 243160011862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160011863 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160011864 putative substrate translocation pore; other site 243160011865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160011866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160011867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160011868 dimerization interface [polypeptide binding]; other site 243160011869 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 243160011870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160011871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160011872 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 243160011873 putative effector binding pocket; other site 243160011874 putative dimerization interface [polypeptide binding]; other site 243160011875 short chain dehydrogenase; Provisional; Region: PRK12937 243160011876 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 243160011877 NADP binding site [chemical binding]; other site 243160011878 homodimer interface [polypeptide binding]; other site 243160011879 active site 243160011880 substrate binding site [chemical binding]; other site 243160011881 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243160011882 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243160011883 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 243160011884 Prostaglandin dehydrogenases; Region: PGDH; cd05288 243160011885 NAD(P) binding site [chemical binding]; other site 243160011886 substrate binding site [chemical binding]; other site 243160011887 dimer interface [polypeptide binding]; other site 243160011888 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 243160011889 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 243160011890 dimer interface [polypeptide binding]; other site 243160011891 active site 243160011892 metal binding site [ion binding]; metal-binding site 243160011893 Peptidase M66; Region: Peptidase_M66; pfam10462 243160011894 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 243160011895 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 243160011896 Domain of unknown function (DUF802); Region: DUF802; pfam05650 243160011897 hypothetical protein; Provisional; Region: PRK09040 243160011898 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160011899 ligand binding site [chemical binding]; other site 243160011900 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 243160011901 Condensation domain; Region: Condensation; pfam00668 243160011902 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160011903 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160011904 acyl-activating enzyme (AAE) consensus motif; other site 243160011905 AMP binding site [chemical binding]; other site 243160011906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160011907 MbtH-like protein; Region: MbtH; pfam03621 243160011908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243160011909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 243160011910 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243160011911 Transposase domain (DUF772); Region: DUF772; pfam05598 243160011912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160011913 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160011914 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160011915 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160011916 trimer interface [polypeptide binding]; other site 243160011917 eyelet of channel; other site 243160011918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160011919 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160011920 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 243160011921 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 243160011922 MOSC domain; Region: MOSC; pfam03473 243160011923 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 243160011924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011925 dimer interface [polypeptide binding]; other site 243160011926 phosphorylation site [posttranslational modification] 243160011927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011928 ATP binding site [chemical binding]; other site 243160011929 Mg2+ binding site [ion binding]; other site 243160011930 G-X-G motif; other site 243160011931 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 243160011932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011933 active site 243160011934 phosphorylation site [posttranslational modification] 243160011935 intermolecular recognition site; other site 243160011936 dimerization interface [polypeptide binding]; other site 243160011937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011938 DNA binding site [nucleotide binding] 243160011939 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243160011940 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160011941 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 243160011942 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243160011943 Walker A/P-loop; other site 243160011944 ATP binding site [chemical binding]; other site 243160011945 Q-loop/lid; other site 243160011946 ABC transporter signature motif; other site 243160011947 Walker B; other site 243160011948 D-loop; other site 243160011949 H-loop/switch region; other site 243160011950 TOBE domain; Region: TOBE_2; pfam08402 243160011951 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160011952 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160011953 trimer interface [polypeptide binding]; other site 243160011954 eyelet of channel; other site 243160011955 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243160011956 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243160011957 NAD(P) binding site [chemical binding]; other site 243160011958 Helix-turn-helix domain; Region: HTH_18; pfam12833 243160011959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160011960 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243160011961 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 243160011962 putative substrate binding pocket [chemical binding]; other site 243160011963 trimer interface [polypeptide binding]; other site 243160011964 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 243160011965 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 243160011966 putative active site [active] 243160011967 putative metal binding site [ion binding]; other site 243160011968 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 243160011969 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 243160011970 NAD binding site [chemical binding]; other site 243160011971 catalytic residues [active] 243160011972 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 243160011973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243160011974 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243160011975 MarR family; Region: MarR_2; cl17246 243160011976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160011977 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160011978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160011979 NAD(P) binding site [chemical binding]; other site 243160011980 active site 243160011981 MltA-interacting protein MipA; Region: MipA; cl01504 243160011982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160011983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160011984 active site 243160011985 phosphorylation site [posttranslational modification] 243160011986 intermolecular recognition site; other site 243160011987 dimerization interface [polypeptide binding]; other site 243160011988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160011989 DNA binding site [nucleotide binding] 243160011990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160011991 dimerization interface [polypeptide binding]; other site 243160011992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160011993 dimer interface [polypeptide binding]; other site 243160011994 phosphorylation site [posttranslational modification] 243160011995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160011996 ATP binding site [chemical binding]; other site 243160011997 Mg2+ binding site [ion binding]; other site 243160011998 G-X-G motif; other site 243160011999 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243160012000 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243160012001 active site 243160012002 non-prolyl cis peptide bond; other site 243160012003 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 243160012004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243160012005 active site 243160012006 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 243160012007 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 243160012008 Flavin binding site [chemical binding]; other site 243160012009 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 243160012010 SnoaL-like domain; Region: SnoaL_2; pfam12680 243160012011 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 243160012012 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160012013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012015 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 243160012016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160012017 catalytic loop [active] 243160012018 iron binding site [ion binding]; other site 243160012019 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 243160012020 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 243160012021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243160012022 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 243160012023 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243160012024 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243160012025 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 243160012026 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243160012027 active site 243160012028 dimer interface [polypeptide binding]; other site 243160012029 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243160012030 Ligand Binding Site [chemical binding]; other site 243160012031 Molecular Tunnel; other site 243160012032 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243160012033 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160012034 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160012035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160012036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012037 DNA binding residues [nucleotide binding] 243160012038 dimerization interface [polypeptide binding]; other site 243160012039 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 243160012040 Subunit I/III interface [polypeptide binding]; other site 243160012041 Trehalase; Region: Trehalase; cl17346 243160012042 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 243160012043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012044 putative substrate translocation pore; other site 243160012045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 243160012047 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 243160012048 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 243160012049 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 243160012050 Transposase; Region: HTH_Tnp_1; pfam01527 243160012051 HTH-like domain; Region: HTH_21; pfam13276 243160012052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012053 Integrase core domain; Region: rve; pfam00665 243160012054 Integrase core domain; Region: rve_3; pfam13683 243160012055 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 243160012056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160012057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160012058 TM-ABC transporter signature motif; other site 243160012059 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 243160012060 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160012061 N-terminal plug; other site 243160012062 ligand-binding site [chemical binding]; other site 243160012063 fec operon regulator FecR; Reviewed; Region: PRK09774 243160012064 FecR protein; Region: FecR; pfam04773 243160012065 RNA polymerase sigma factor; Provisional; Region: PRK12528 243160012066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160012067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160012068 DNA binding residues [nucleotide binding] 243160012069 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 243160012070 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 243160012071 YceI-like domain; Region: YceI; pfam04264 243160012072 RNA polymerase sigma factor; Provisional; Region: PRK12547 243160012073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243160012074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243160012075 DNA binding residues [nucleotide binding] 243160012076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160012077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012078 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243160012079 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243160012080 CAAX protease self-immunity; Region: Abi; pfam02517 243160012081 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 243160012082 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160012083 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 243160012084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160012085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012086 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160012087 putative effector binding pocket; other site 243160012088 dimerization interface [polypeptide binding]; other site 243160012089 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 243160012090 HPP family; Region: HPP; pfam04982 243160012091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 243160012092 MarR family; Region: MarR_2; pfam12802 243160012093 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243160012094 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243160012095 Cl- selectivity filter; other site 243160012096 Cl- binding residues [ion binding]; other site 243160012097 pore gating glutamate residue; other site 243160012098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 243160012099 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243160012100 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 243160012101 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243160012102 putative NADP binding site [chemical binding]; other site 243160012103 KR domain; Region: KR; pfam08659 243160012104 active site 243160012105 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012106 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160012107 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243160012108 active site 243160012109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012110 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012111 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160012112 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243160012113 active site 243160012114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160012115 Methyltransferase domain; Region: Methyltransf_12; pfam08242 243160012116 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243160012117 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012118 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160012119 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243160012120 active site 243160012121 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012122 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160012123 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012124 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243160012125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160012126 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160012127 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243160012128 active site 243160012129 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243160012130 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243160012131 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243160012132 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243160012133 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 243160012134 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 243160012135 dimer interface [polypeptide binding]; other site 243160012136 active site 243160012137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160012138 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160012139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160012140 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 243160012141 substrate binding site [chemical binding]; other site 243160012142 oxyanion hole (OAH) forming residues; other site 243160012143 trimer interface [polypeptide binding]; other site 243160012144 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 243160012145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243160012146 substrate binding site [chemical binding]; other site 243160012147 oxyanion hole (OAH) forming residues; other site 243160012148 trimer interface [polypeptide binding]; other site 243160012149 acyl carrier protein; Validated; Region: PRK07117 243160012150 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 243160012151 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243160012152 dimer interface [polypeptide binding]; other site 243160012153 active site 243160012154 TPR repeat; Region: TPR_11; pfam13414 243160012155 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243160012156 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243160012157 iron-sulfur cluster [ion binding]; other site 243160012158 [2Fe-2S] cluster binding site [ion binding]; other site 243160012159 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243160012160 hydrophobic ligand binding site; other site 243160012161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160012162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160012163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243160012164 S-adenosylmethionine binding site [chemical binding]; other site 243160012165 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 243160012166 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 243160012167 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 243160012168 tetramer interface [polypeptide binding]; other site 243160012169 heme binding pocket [chemical binding]; other site 243160012170 Transposase; Region: HTH_Tnp_1; pfam01527 243160012171 HTH-like domain; Region: HTH_21; pfam13276 243160012172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012173 Integrase core domain; Region: rve; pfam00665 243160012174 Integrase core domain; Region: rve_3; pfam13683 243160012175 Histidine kinase; Region: His_kinase; pfam06580 243160012176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160012177 ATP binding site [chemical binding]; other site 243160012178 Mg2+ binding site [ion binding]; other site 243160012179 G-X-G motif; other site 243160012180 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 243160012181 Uncharacterized conserved protein [Function unknown]; Region: COG3791 243160012182 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 243160012183 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 243160012184 putative active site [active] 243160012185 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 243160012186 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160012187 Walker A/P-loop; other site 243160012188 ATP binding site [chemical binding]; other site 243160012189 Q-loop/lid; other site 243160012190 ABC transporter signature motif; other site 243160012191 Walker B; other site 243160012192 D-loop; other site 243160012193 H-loop/switch region; other site 243160012194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160012195 dimer interface [polypeptide binding]; other site 243160012196 conserved gate region; other site 243160012197 putative PBP binding loops; other site 243160012198 ABC-ATPase subunit interface; other site 243160012199 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160012200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160012201 dimer interface [polypeptide binding]; other site 243160012202 conserved gate region; other site 243160012203 putative PBP binding loops; other site 243160012204 ABC-ATPase subunit interface; other site 243160012205 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 243160012206 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012207 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012208 trimer interface [polypeptide binding]; other site 243160012209 eyelet of channel; other site 243160012210 Predicted membrane protein [Function unknown]; Region: COG2259 243160012211 Cytochrome c; Region: Cytochrom_C; pfam00034 243160012212 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160012213 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243160012214 Cytochrome c; Region: Cytochrom_C; pfam00034 243160012215 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243160012216 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160012217 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 243160012218 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 243160012219 active site 243160012220 catalytic triad [active] 243160012221 magnesium-transporting ATPase; Provisional; Region: PRK15122 243160012222 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 243160012223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243160012224 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243160012225 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243160012226 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243160012227 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 243160012228 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160012229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160012230 DNA-binding site [nucleotide binding]; DNA binding site 243160012231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160012232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012233 homodimer interface [polypeptide binding]; other site 243160012234 catalytic residue [active] 243160012235 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 243160012236 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 243160012237 putative molybdopterin cofactor binding site [chemical binding]; other site 243160012238 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 243160012239 putative molybdopterin cofactor binding site; other site 243160012240 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 243160012241 Predicted membrane protein [Function unknown]; Region: COG4682 243160012242 yiaA/B two helix domain; Region: YiaAB; pfam05360 243160012243 yiaA/B two helix domain; Region: YiaAB; pfam05360 243160012244 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 243160012245 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243160012246 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 243160012247 Cupin; Region: Cupin_1; smart00835 243160012248 Cupin; Region: Cupin_1; smart00835 243160012249 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 243160012250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243160012251 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 243160012252 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 243160012253 catalytic triad [active] 243160012254 putative active site [active] 243160012255 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 243160012256 Autotransporter beta-domain; Region: Autotransporter; smart00869 243160012257 PAAR motif; Region: PAAR_motif; pfam05488 243160012258 RHS Repeat; Region: RHS_repeat; cl11982 243160012259 RHS Repeat; Region: RHS_repeat; pfam05593 243160012260 RHS Repeat; Region: RHS_repeat; cl11982 243160012261 RHS Repeat; Region: RHS_repeat; pfam05593 243160012262 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243160012263 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 243160012264 RHS Repeat; Region: RHS_repeat; pfam05593 243160012265 RHS Repeat; Region: RHS_repeat; cl11982 243160012266 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 243160012267 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 243160012268 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243160012269 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160012270 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160012271 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 243160012272 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243160012273 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 243160012274 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 243160012275 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 243160012276 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 243160012277 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 243160012278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243160012279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160012280 dimer interface [polypeptide binding]; other site 243160012281 conserved gate region; other site 243160012282 putative PBP binding loops; other site 243160012283 ABC-ATPase subunit interface; other site 243160012284 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 243160012285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160012286 dimer interface [polypeptide binding]; other site 243160012287 conserved gate region; other site 243160012288 putative PBP binding loops; other site 243160012289 ABC-ATPase subunit interface; other site 243160012290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 243160012291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160012292 Walker A/P-loop; other site 243160012293 ATP binding site [chemical binding]; other site 243160012294 Q-loop/lid; other site 243160012295 ABC transporter signature motif; other site 243160012296 Walker B; other site 243160012297 D-loop; other site 243160012298 H-loop/switch region; other site 243160012299 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 243160012300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243160012301 Walker A/P-loop; other site 243160012302 ATP binding site [chemical binding]; other site 243160012303 Q-loop/lid; other site 243160012304 ABC transporter signature motif; other site 243160012305 Walker B; other site 243160012306 D-loop; other site 243160012307 H-loop/switch region; other site 243160012308 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160012309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012310 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 243160012311 substrate binding pocket [chemical binding]; other site 243160012312 dimerization interface [polypeptide binding]; other site 243160012313 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 243160012314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243160012315 Peptidase family M23; Region: Peptidase_M23; pfam01551 243160012316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160012317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012318 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 243160012319 putative dimerization interface [polypeptide binding]; other site 243160012320 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012321 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012322 trimer interface [polypeptide binding]; other site 243160012323 eyelet of channel; other site 243160012324 OpgC protein; Region: OpgC_C; pfam10129 243160012325 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 243160012326 Putative esterase; Region: Esterase; pfam00756 243160012327 ornithine cyclodeaminase; Validated; Region: PRK07340 243160012328 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243160012329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160012330 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243160012331 Ion channel; Region: Ion_trans_2; pfam07885 243160012332 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243160012333 TrkA-N domain; Region: TrkA_N; pfam02254 243160012334 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243160012335 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243160012336 BetR domain; Region: BetR; pfam08667 243160012337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160012338 active site 243160012339 phosphorylation site [posttranslational modification] 243160012340 intermolecular recognition site; other site 243160012341 dimerization interface [polypeptide binding]; other site 243160012342 Family description; Region: UvrD_C_2; pfam13538 243160012343 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243160012344 Tar ligand binding domain homologue; Region: TarH; pfam02203 243160012345 dimer interface [polypeptide binding]; other site 243160012346 ligand binding site [chemical binding]; other site 243160012347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160012348 dimerization interface [polypeptide binding]; other site 243160012349 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160012350 dimer interface [polypeptide binding]; other site 243160012351 putative CheW interface [polypeptide binding]; other site 243160012352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012353 putative substrate translocation pore; other site 243160012354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012355 putative substrate translocation pore; other site 243160012356 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 243160012357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160012358 Coenzyme A binding pocket [chemical binding]; other site 243160012359 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 243160012360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243160012361 DNA binding residues [nucleotide binding] 243160012362 putative dimer interface [polypeptide binding]; other site 243160012363 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 243160012364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160012365 substrate binding pocket [chemical binding]; other site 243160012366 membrane-bound complex binding site; other site 243160012367 hinge residues; other site 243160012368 YhhN-like protein; Region: YhhN; pfam07947 243160012369 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243160012370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243160012371 Transposase; Region: HTH_Tnp_1; pfam01527 243160012372 HTH-like domain; Region: HTH_21; pfam13276 243160012373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012374 Integrase core domain; Region: rve; pfam00665 243160012375 Integrase core domain; Region: rve_3; pfam13683 243160012376 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 243160012377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160012378 Predicted transcriptional regulator [Transcription]; Region: COG1959 243160012379 Transcriptional regulator; Region: Rrf2; pfam02082 243160012380 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 243160012381 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 243160012382 methionine gamma-lyase; Validated; Region: PRK07049 243160012383 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243160012384 homodimer interface [polypeptide binding]; other site 243160012385 substrate-cofactor binding pocket; other site 243160012386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012387 catalytic residue [active] 243160012388 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160012389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160012390 dimerization interface [polypeptide binding]; other site 243160012391 putative DNA binding site [nucleotide binding]; other site 243160012392 putative Zn2+ binding site [ion binding]; other site 243160012393 AsnC family; Region: AsnC_trans_reg; pfam01037 243160012394 amidase; Provisional; Region: PRK07486 243160012395 Amidase; Region: Amidase; cl11426 243160012396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243160012397 Ligand Binding Site [chemical binding]; other site 243160012398 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 243160012399 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 243160012400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160012401 ligand binding site [chemical binding]; other site 243160012402 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 243160012403 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160012404 trimer interface [polypeptide binding]; other site 243160012405 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160012406 trimer interface [polypeptide binding]; other site 243160012407 Haemagglutinin; Region: HIM; pfam05662 243160012408 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243160012409 trimer interface [polypeptide binding]; other site 243160012410 Haemagglutinin; Region: HIM; pfam05662 243160012411 Haemagglutinin; Region: HIM; pfam05662 243160012412 YadA-like C-terminal region; Region: YadA; pfam03895 243160012413 benzoate transport; Region: 2A0115; TIGR00895 243160012414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012415 putative substrate translocation pore; other site 243160012416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012417 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 243160012418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160012419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160012420 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 243160012421 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 243160012422 active site 243160012423 metal binding site [ion binding]; metal-binding site 243160012424 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 243160012425 putative active site [active] 243160012426 putative metal binding site [ion binding]; other site 243160012427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160012428 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 243160012429 NAD(P) binding site [chemical binding]; other site 243160012430 catalytic residues [active] 243160012431 L-aspartate dehydrogenase; Provisional; Region: PRK13303 243160012432 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243160012433 Domain of unknown function DUF108; Region: DUF108; pfam01958 243160012434 hypothetical protein; Provisional; Region: PRK07064 243160012435 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160012436 PYR/PP interface [polypeptide binding]; other site 243160012437 dimer interface [polypeptide binding]; other site 243160012438 TPP binding site [chemical binding]; other site 243160012439 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160012440 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 243160012441 TPP-binding site [chemical binding]; other site 243160012442 short chain dehydrogenase; Provisional; Region: PRK07062 243160012443 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 243160012444 putative NAD(P) binding site [chemical binding]; other site 243160012445 putative active site [active] 243160012446 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160012447 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160012448 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160012449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160012450 Cupin domain; Region: Cupin_2; pfam07883 243160012451 short chain dehydrogenase; Provisional; Region: PRK12939 243160012452 classical (c) SDRs; Region: SDR_c; cd05233 243160012453 NAD(P) binding site [chemical binding]; other site 243160012454 active site 243160012455 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243160012456 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243160012457 [2Fe-2S] cluster binding site [ion binding]; other site 243160012458 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243160012459 hydrophobic ligand binding site; other site 243160012460 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 243160012461 [2Fe-2S] cluster binding site [ion binding]; other site 243160012462 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012463 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012464 trimer interface [polypeptide binding]; other site 243160012465 eyelet of channel; other site 243160012466 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160012467 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160012468 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160012469 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 243160012470 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 243160012471 putative FMN binding site [chemical binding]; other site 243160012472 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 243160012473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243160012474 putative active site [active] 243160012475 putative metal binding site [ion binding]; other site 243160012476 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 243160012477 MgtC family; Region: MgtC; pfam02308 243160012478 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 243160012479 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160012480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012481 DNA binding residues [nucleotide binding] 243160012482 dimerization interface [polypeptide binding]; other site 243160012483 Autoinducer synthetase; Region: Autoind_synth; cl17404 243160012484 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 243160012485 NADH/NADPH cofactor binding site [chemical binding]; other site 243160012486 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243160012487 dimerization interface [polypeptide binding]; other site 243160012488 active site 243160012489 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 243160012490 FOG: CBS domain [General function prediction only]; Region: COG0517 243160012491 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 243160012492 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 243160012493 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243160012494 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012495 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012496 trimer interface [polypeptide binding]; other site 243160012497 eyelet of channel; other site 243160012498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160012499 putative DNA binding site [nucleotide binding]; other site 243160012500 dimerization interface [polypeptide binding]; other site 243160012501 putative Zn2+ binding site [ion binding]; other site 243160012502 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243160012503 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 243160012504 FMN binding site [chemical binding]; other site 243160012505 active site 243160012506 substrate binding site [chemical binding]; other site 243160012507 catalytic residue [active] 243160012508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243160012509 Coenzyme A binding pocket [chemical binding]; other site 243160012510 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160012511 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012512 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012513 eyelet of channel; other site 243160012514 trimer interface [polypeptide binding]; other site 243160012515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160012516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012517 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 243160012518 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243160012519 hypothetical protein; Provisional; Region: PRK07481 243160012520 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160012521 inhibitor-cofactor binding pocket; inhibition site 243160012522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012523 catalytic residue [active] 243160012524 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160012525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243160012526 NAD(P) binding site [chemical binding]; other site 243160012527 catalytic residues [active] 243160012528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160012529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012530 DNA binding residues [nucleotide binding] 243160012531 dimerization interface [polypeptide binding]; other site 243160012532 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 243160012533 classical (c) SDRs; Region: SDR_c; cd05233 243160012534 NAD(P) binding site [chemical binding]; other site 243160012535 active site 243160012536 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 243160012537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243160012538 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243160012539 active site 243160012540 catalytic tetrad [active] 243160012541 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 243160012542 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 243160012543 catalytic residues [active] 243160012544 transcriptional regulator; Provisional; Region: PRK10632 243160012545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012546 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160012547 putative effector binding pocket; other site 243160012548 dimerization interface [polypeptide binding]; other site 243160012549 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 243160012550 flagellar capping protein; Reviewed; Region: fliD; PRK08032 243160012551 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 243160012552 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243160012553 DEAD_2; Region: DEAD_2; pfam06733 243160012554 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243160012555 Transposase; Region: HTH_Tnp_1; pfam01527 243160012556 HTH-like domain; Region: HTH_21; pfam13276 243160012557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012558 Integrase core domain; Region: rve; pfam00665 243160012559 Integrase core domain; Region: rve_3; pfam13683 243160012560 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 243160012561 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 243160012562 tetrameric interface [polypeptide binding]; other site 243160012563 NAD binding site [chemical binding]; other site 243160012564 catalytic residues [active] 243160012565 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 243160012566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160012567 inhibitor-cofactor binding pocket; inhibition site 243160012568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012569 catalytic residue [active] 243160012570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160012571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160012573 dimerization interface [polypeptide binding]; other site 243160012574 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 243160012575 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160012576 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160012577 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 243160012578 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243160012579 DXD motif; other site 243160012580 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 243160012581 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 243160012582 acyl-CoA synthetase; Validated; Region: PRK08162 243160012583 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 243160012584 acyl-activating enzyme (AAE) consensus motif; other site 243160012585 putative active site [active] 243160012586 AMP binding site [chemical binding]; other site 243160012587 putative CoA binding site [chemical binding]; other site 243160012588 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243160012589 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243160012590 ligand binding site [chemical binding]; other site 243160012591 flexible hinge region; other site 243160012592 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 243160012593 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 243160012594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160012595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160012596 DNA-binding site [nucleotide binding]; DNA binding site 243160012597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160012598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012599 homodimer interface [polypeptide binding]; other site 243160012600 catalytic residue [active] 243160012601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243160012602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160012603 NAD(P) binding site [chemical binding]; other site 243160012604 active site 243160012605 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 243160012606 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243160012607 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 243160012608 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243160012609 NAD binding site [chemical binding]; other site 243160012610 homotetramer interface [polypeptide binding]; other site 243160012611 homodimer interface [polypeptide binding]; other site 243160012612 substrate binding site [chemical binding]; other site 243160012613 active site 243160012614 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243160012615 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 243160012616 active site 243160012617 FMN binding site [chemical binding]; other site 243160012618 substrate binding site [chemical binding]; other site 243160012619 homotetramer interface [polypeptide binding]; other site 243160012620 catalytic residue [active] 243160012621 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243160012622 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 243160012623 potential catalytic triad [active] 243160012624 conserved cys residue [active] 243160012625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243160012626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160012627 MASE1; Region: MASE1; pfam05231 243160012628 PAS fold; Region: PAS_3; pfam08447 243160012629 Transposase; Region: HTH_Tnp_1; pfam01527 243160012630 HTH-like domain; Region: HTH_21; pfam13276 243160012631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012632 Integrase core domain; Region: rve; pfam00665 243160012633 Integrase core domain; Region: rve_3; pfam13683 243160012634 PAS fold; Region: PAS_4; pfam08448 243160012635 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160012636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243160012638 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 243160012639 FAD dependent oxidoreductase; Region: DAO; pfam01266 243160012640 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243160012641 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 243160012642 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 243160012643 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 243160012644 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 243160012645 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243160012646 inhibitor site; inhibition site 243160012647 active site 243160012648 dimer interface [polypeptide binding]; other site 243160012649 catalytic residue [active] 243160012650 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243160012651 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 243160012652 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 243160012653 dimer interface [polypeptide binding]; other site 243160012654 NADP binding site [chemical binding]; other site 243160012655 catalytic residues [active] 243160012656 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 243160012657 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160012658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012659 putative substrate translocation pore; other site 243160012660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012661 putative substrate translocation pore; other site 243160012662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012663 Predicted membrane protein [Function unknown]; Region: COG2259 243160012664 glycolate transporter; Provisional; Region: PRK09695 243160012665 L-lactate permease; Region: Lactate_perm; cl00701 243160012666 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 243160012667 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 243160012668 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243160012669 4Fe-4S binding domain; Region: Fer4; pfam00037 243160012670 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 243160012671 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243160012672 Cysteine-rich domain; Region: CCG; pfam02754 243160012673 Cysteine-rich domain; Region: CCG; pfam02754 243160012674 transcriptional regulator NanR; Provisional; Region: PRK03837 243160012675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160012676 DNA-binding site [nucleotide binding]; DNA binding site 243160012677 FCD domain; Region: FCD; pfam07729 243160012678 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 243160012679 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 243160012680 Flavin binding site [chemical binding]; other site 243160012681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160012682 dimer interface [polypeptide binding]; other site 243160012683 conserved gate region; other site 243160012684 ABC-ATPase subunit interface; other site 243160012685 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 243160012686 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 243160012687 Walker A/P-loop; other site 243160012688 ATP binding site [chemical binding]; other site 243160012689 Q-loop/lid; other site 243160012690 ABC transporter signature motif; other site 243160012691 Walker B; other site 243160012692 D-loop; other site 243160012693 H-loop/switch region; other site 243160012694 NIL domain; Region: NIL; pfam09383 243160012695 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243160012696 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243160012697 active site 243160012698 non-prolyl cis peptide bond; other site 243160012699 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 243160012700 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160012701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012702 DNA binding residues [nucleotide binding] 243160012703 dimerization interface [polypeptide binding]; other site 243160012704 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 243160012705 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160012706 AMP-binding enzyme; Region: AMP-binding; pfam00501 243160012707 acyl-activating enzyme (AAE) consensus motif; other site 243160012708 AMP binding site [chemical binding]; other site 243160012709 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160012710 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 243160012711 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160012712 active site 243160012713 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243160012714 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243160012715 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 243160012716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160012717 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243160012718 NAD(P) binding site [chemical binding]; other site 243160012719 active site 243160012720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160012721 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 243160012722 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 243160012723 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160012724 hypothetical protein; Provisional; Region: PRK07036 243160012725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160012726 inhibitor-cofactor binding pocket; inhibition site 243160012727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012728 catalytic residue [active] 243160012729 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 243160012730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243160012731 NAD(P) binding site [chemical binding]; other site 243160012732 catalytic residues [active] 243160012733 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 243160012734 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243160012735 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243160012736 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 243160012737 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 243160012738 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 243160012739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243160012740 catalytic residue [active] 243160012741 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243160012742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160012743 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243160012744 acyl-activating enzyme (AAE) consensus motif; other site 243160012745 AMP binding site [chemical binding]; other site 243160012746 active site 243160012747 CoA binding site [chemical binding]; other site 243160012748 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243160012749 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243160012750 acyl-CoA synthetase; Validated; Region: PRK05850 243160012751 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243160012752 acyl-activating enzyme (AAE) consensus motif; other site 243160012753 active site 243160012754 Membrane transport protein; Region: Mem_trans; cl09117 243160012755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160012756 Coenzyme A binding pocket [chemical binding]; other site 243160012757 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243160012758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160012759 DNA-binding site [nucleotide binding]; DNA binding site 243160012760 FCD domain; Region: FCD; pfam07729 243160012761 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 243160012762 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 243160012763 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243160012764 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243160012765 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243160012766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243160012767 HlyD family secretion protein; Region: HlyD_3; pfam13437 243160012768 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243160012769 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243160012770 substrate binding pocket [chemical binding]; other site 243160012771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160012772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012773 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 243160012774 putative effector binding pocket; other site 243160012775 putative dimerization interface [polypeptide binding]; other site 243160012776 Purine nucleoside permease (NUP); Region: NUP; pfam06516 243160012777 selenophosphate synthetase; Provisional; Region: PRK00943 243160012778 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 243160012779 dimerization interface [polypeptide binding]; other site 243160012780 putative ATP binding site [chemical binding]; other site 243160012781 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 243160012782 EamA-like transporter family; Region: EamA; cl17759 243160012783 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 243160012784 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243160012785 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160012786 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160012787 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 243160012788 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 243160012789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160012790 DNA-binding site [nucleotide binding]; DNA binding site 243160012791 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160012792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160012793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012794 homodimer interface [polypeptide binding]; other site 243160012795 catalytic residue [active] 243160012796 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 243160012797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160012798 inhibitor-cofactor binding pocket; inhibition site 243160012799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160012800 catalytic residue [active] 243160012801 succinic semialdehyde dehydrogenase; Region: PLN02278 243160012802 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 243160012803 tetramerization interface [polypeptide binding]; other site 243160012804 NAD(P) binding site [chemical binding]; other site 243160012805 catalytic residues [active] 243160012806 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 243160012807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160012808 S-adenosylmethionine binding site [chemical binding]; other site 243160012809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160012810 PAS domain; Region: PAS_9; pfam13426 243160012811 putative active site [active] 243160012812 heme pocket [chemical binding]; other site 243160012813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160012814 dimer interface [polypeptide binding]; other site 243160012815 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 243160012816 putative CheW interface [polypeptide binding]; other site 243160012817 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 243160012818 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243160012819 dimer interface [polypeptide binding]; other site 243160012820 active site 243160012821 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 243160012822 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243160012823 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160012824 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 243160012825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243160012826 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 243160012827 metabolite-proton symporter; Region: 2A0106; TIGR00883 243160012828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012829 putative substrate translocation pore; other site 243160012830 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 243160012831 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 243160012832 metal binding site [ion binding]; metal-binding site 243160012833 putative dimer interface [polypeptide binding]; other site 243160012834 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 243160012835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160012837 dimerization interface [polypeptide binding]; other site 243160012838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160012839 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160012840 substrate binding pocket [chemical binding]; other site 243160012841 membrane-bound complex binding site; other site 243160012842 hinge residues; other site 243160012843 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160012844 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 243160012845 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 243160012846 active site 243160012847 Zn binding site [ion binding]; other site 243160012848 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 243160012849 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 243160012850 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012851 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012852 trimer interface [polypeptide binding]; other site 243160012853 eyelet of channel; other site 243160012854 HTH-like domain; Region: HTH_21; pfam13276 243160012855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012856 Integrase core domain; Region: rve; pfam00665 243160012857 Integrase core domain; Region: rve_3; pfam13683 243160012858 Transposase; Region: HTH_Tnp_1; pfam01527 243160012859 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160012860 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160012861 Transposase domain (DUF772); Region: DUF772; pfam05598 243160012862 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160012863 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160012864 LysR family transcriptional regulator; Provisional; Region: PRK14997 243160012865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012866 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 243160012867 putative effector binding pocket; other site 243160012868 putative dimerization interface [polypeptide binding]; other site 243160012869 Pirin-related protein [General function prediction only]; Region: COG1741 243160012870 Pirin; Region: Pirin; pfam02678 243160012871 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243160012872 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 243160012873 putative hydrophobic ligand binding site [chemical binding]; other site 243160012874 Hemin uptake protein hemP; Region: hemP; pfam10636 243160012875 HTH-like domain; Region: HTH_21; pfam13276 243160012876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160012877 Integrase core domain; Region: rve; pfam00665 243160012878 Integrase core domain; Region: rve_3; pfam13683 243160012879 Transposase; Region: HTH_Tnp_1; pfam01527 243160012880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160012881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160012883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160012884 active site 243160012885 phosphorylation site [posttranslational modification] 243160012886 intermolecular recognition site; other site 243160012887 dimerization interface [polypeptide binding]; other site 243160012888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012889 DNA binding residues [nucleotide binding] 243160012890 dimerization interface [polypeptide binding]; other site 243160012891 chaperone protein SicP; Provisional; Region: PRK15329 243160012892 SicP binding; Region: SicP-binding; pfam09119 243160012893 type III secretion protein BopE; Provisional; Region: PRK15278 243160012894 SopE GEF domain; Region: SopE_GEF; pfam07487 243160012895 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243160012896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243160012897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243160012898 catalytic residue [active] 243160012899 Phosphopantetheine attachment site; Region: PP-binding; cl09936 243160012900 type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553 243160012901 H-NS histone family; Region: Histone_HNS; pfam00816 243160012902 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243160012903 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; pfam09599 243160012904 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 243160012905 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 243160012906 Tetratricopeptide repeat; Region: TPR_3; pfam07720 243160012907 Tetratricopeptide repeat; Region: TPR_3; pfam07720 243160012908 type III secretion system protein SpaS; Validated; Region: PRK08156 243160012909 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 243160012910 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 243160012911 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 243160012912 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 243160012913 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243160012914 ATP synthase SpaL; Validated; Region: PRK08149 243160012915 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243160012916 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243160012917 Walker A motif; other site 243160012918 ATP binding site [chemical binding]; other site 243160012919 Walker B motif; other site 243160012920 Invasion protein B family; Region: Invas_SpaK; cl04129 243160012921 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 243160012922 type III secretion system protein InvA; Provisional; Region: PRK15337 243160012923 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 243160012924 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160012925 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160012926 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 243160012927 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160012928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160012929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160012930 type III secretion system protein PrgH/EprH; Region: PrgH; TIGR02554 243160012931 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 243160012932 Type III secretion needle MxiH like; Region: MxiH; cl09641 243160012933 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 243160012934 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 243160012935 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 243160012936 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 243160012937 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 243160012938 DNA binding site [nucleotide binding] 243160012939 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 243160012940 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 243160012941 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 243160012942 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 243160012943 active site 243160012944 Zn binding site [ion binding]; other site 243160012945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243160012946 MarR family; Region: MarR_2; cl17246 243160012947 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 243160012948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160012949 dimer interface [polypeptide binding]; other site 243160012950 putative metal binding site [ion binding]; other site 243160012951 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 243160012952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160012953 putative substrate translocation pore; other site 243160012954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160012955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160012956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160012957 dimerization interface [polypeptide binding]; other site 243160012958 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 243160012959 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243160012960 phosphate binding site [ion binding]; other site 243160012961 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 243160012962 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 243160012963 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 243160012964 peptidase domain interface [polypeptide binding]; other site 243160012965 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 243160012966 active site 243160012967 catalytic triad [active] 243160012968 calcium binding site [ion binding]; other site 243160012969 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243160012970 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160012971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160012972 putative DNA binding site [nucleotide binding]; other site 243160012973 putative Zn2+ binding site [ion binding]; other site 243160012974 AsnC family; Region: AsnC_trans_reg; pfam01037 243160012975 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 243160012976 putative hydrophobic ligand binding site [chemical binding]; other site 243160012977 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243160012978 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243160012979 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 243160012980 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 243160012981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160012982 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 243160012983 putative AMP binding site [chemical binding]; other site 243160012984 putative active site [active] 243160012985 acyl-activating enzyme (AAE) consensus motif; other site 243160012986 putative CoA binding site [chemical binding]; other site 243160012987 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160012988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160012989 DNA binding residues [nucleotide binding] 243160012990 dimerization interface [polypeptide binding]; other site 243160012991 Autoinducer synthetase; Region: Autoind_synth; cl17404 243160012992 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 243160012993 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243160012994 putative active site [active] 243160012995 putative FMN binding site [chemical binding]; other site 243160012996 putative substrate binding site [chemical binding]; other site 243160012997 putative catalytic residue [active] 243160012998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243160012999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160013000 dimer interface [polypeptide binding]; other site 243160013001 conserved gate region; other site 243160013002 putative PBP binding loops; other site 243160013003 ABC-ATPase subunit interface; other site 243160013004 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243160013005 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 243160013006 Walker A/P-loop; other site 243160013007 ATP binding site [chemical binding]; other site 243160013008 Q-loop/lid; other site 243160013009 ABC transporter signature motif; other site 243160013010 Walker B; other site 243160013011 D-loop; other site 243160013012 H-loop/switch region; other site 243160013013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160013014 membrane-bound complex binding site; other site 243160013015 hinge residues; other site 243160013016 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160013017 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243160013018 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 243160013019 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 243160013020 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 243160013021 DXD motif; other site 243160013022 PilZ domain; Region: PilZ; pfam07238 243160013023 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 243160013024 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 243160013025 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 243160013026 endo-1,4-D-glucanase; Provisional; Region: PRK11097 243160013027 cellulose synthase regulator protein; Provisional; Region: PRK11114 243160013028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243160013029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243160013030 non-specific DNA binding site [nucleotide binding]; other site 243160013031 salt bridge; other site 243160013032 sequence-specific DNA binding site [nucleotide binding]; other site 243160013033 HipA N-terminal domain; Region: couple_hipA; TIGR03071 243160013034 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 243160013035 HipA-like N-terminal domain; Region: HipA_N; pfam07805 243160013036 HipA-like C-terminal domain; Region: HipA_C; pfam07804 243160013037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243160013040 dimerization interface [polypeptide binding]; other site 243160013041 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 243160013042 agmatinase; Region: agmatinase; TIGR01230 243160013043 oligomer interface [polypeptide binding]; other site 243160013044 putative active site [active] 243160013045 Mn binding site [ion binding]; other site 243160013046 type II secretion system protein D; Region: type_II_gspD; TIGR02517 243160013047 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160013048 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243160013049 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160013050 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 243160013051 PilM; Region: PilM; pfam07419 243160013052 PilS N terminal; Region: PilS; pfam08805 243160013053 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160013054 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243160013055 Type II/IV secretion system protein; Region: T2SE; pfam00437 243160013056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243160013057 Walker A motif; other site 243160013058 ATP binding site [chemical binding]; other site 243160013059 Walker B motif; other site 243160013060 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 243160013061 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 243160013062 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243160013063 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 243160013064 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243160013065 Walker A motif; other site 243160013066 ATP binding site [chemical binding]; other site 243160013067 Walker B motif; other site 243160013068 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 243160013069 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243160013070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160013071 active site 243160013072 phosphorylation site [posttranslational modification] 243160013073 intermolecular recognition site; other site 243160013074 dimerization interface [polypeptide binding]; other site 243160013075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243160013076 DNA binding site [nucleotide binding] 243160013077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160013078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160013079 ATP binding site [chemical binding]; other site 243160013080 Mg2+ binding site [ion binding]; other site 243160013081 G-X-G motif; other site 243160013082 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 243160013083 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 243160013084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160013085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160013086 Tir chaperone protein (CesT) family; Region: CesT; cl08444 243160013087 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 243160013088 type III secretion system protein YscR; Provisional; Region: PRK12797 243160013089 Type III secretion protein (HpaP); Region: HpaP; cl17849 243160013090 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243160013091 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 243160013092 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 243160013093 FHIPEP family; Region: FHIPEP; pfam00771 243160013094 type III secretion system protein HrcU; Validated; Region: PRK09108 243160013095 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 243160013096 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 243160013097 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 243160013098 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 243160013099 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 243160013100 type III secretion system protein HrpB; Validated; Region: PRK09098 243160013101 Flagellar assembly protein FliH; Region: FliH; pfam02108 243160013102 type III secretion system ATPase; Provisional; Region: PRK09099 243160013103 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243160013104 Walker A motif; other site 243160013105 ATP binding site [chemical binding]; other site 243160013106 Walker B motif; other site 243160013107 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 243160013108 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160013109 substrate binding pocket [chemical binding]; other site 243160013110 active site 243160013111 iron coordination sites [ion binding]; other site 243160013112 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160013113 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160013114 acyl-activating enzyme (AAE) consensus motif; other site 243160013115 AMP binding site [chemical binding]; other site 243160013116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160013117 Condensation domain; Region: Condensation; pfam00668 243160013118 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160013119 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243160013120 acyl-activating enzyme (AAE) consensus motif; other site 243160013121 AMP binding site [chemical binding]; other site 243160013122 active site 243160013123 CoA binding site [chemical binding]; other site 243160013124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160013125 Condensation domain; Region: Condensation; pfam00668 243160013126 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243160013127 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243160013128 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 243160013129 acyl-activating enzyme (AAE) consensus motif; other site 243160013130 AMP binding site [chemical binding]; other site 243160013131 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160013132 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243160013133 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243160013134 HTH-like domain; Region: HTH_21; pfam13276 243160013135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160013136 Integrase core domain; Region: rve; pfam00665 243160013137 Integrase core domain; Region: rve_3; pfam13683 243160013138 Transposase; Region: HTH_Tnp_1; pfam01527 243160013139 Condensation domain; Region: Condensation; pfam00668 243160013140 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243160013141 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243160013142 acyl-activating enzyme (AAE) consensus motif; other site 243160013143 AMP binding site [chemical binding]; other site 243160013144 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243160013145 Condensation domain; Region: Condensation; pfam00668 243160013146 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 243160013147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160013148 inhibitor-cofactor binding pocket; inhibition site 243160013149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013150 catalytic residue [active] 243160013151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160013152 putative substrate translocation pore; other site 243160013153 pyruvate dehydrogenase; Provisional; Region: PRK09124 243160013154 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 243160013155 PYR/PP interface [polypeptide binding]; other site 243160013156 tetramer interface [polypeptide binding]; other site 243160013157 dimer interface [polypeptide binding]; other site 243160013158 TPP binding site [chemical binding]; other site 243160013159 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243160013160 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 243160013161 TPP-binding site [chemical binding]; other site 243160013162 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 243160013163 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 243160013164 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243160013165 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 243160013166 putative active site [active] 243160013167 putative catalytic site [active] 243160013168 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243160013169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013171 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 243160013172 putative dimerization interface [polypeptide binding]; other site 243160013173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013175 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160013176 putative effector binding pocket; other site 243160013177 dimerization interface [polypeptide binding]; other site 243160013178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160013179 putative substrate translocation pore; other site 243160013180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 243160013181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160013182 ATP binding site [chemical binding]; other site 243160013183 Mg2+ binding site [ion binding]; other site 243160013184 G-X-G motif; other site 243160013185 Uncharacterized conserved protein [Function unknown]; Region: COG3287 243160013186 FIST N domain; Region: FIST; pfam08495 243160013187 FIST C domain; Region: FIST_C; pfam10442 243160013188 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243160013189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160013190 active site 243160013191 phosphorylation site [posttranslational modification] 243160013192 intermolecular recognition site; other site 243160013193 dimerization interface [polypeptide binding]; other site 243160013194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243160013195 Zn2+ binding site [ion binding]; other site 243160013196 Mg2+ binding site [ion binding]; other site 243160013197 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 243160013198 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 243160013199 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 243160013200 putative sugar binding sites [chemical binding]; other site 243160013201 Q-X-W motif; other site 243160013202 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 243160013203 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 243160013204 putative sugar binding sites [chemical binding]; other site 243160013205 Q-X-W motif; other site 243160013206 Kelch motif; Region: Kelch_6; pfam13964 243160013207 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 243160013208 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243160013209 Cu(I) binding site [ion binding]; other site 243160013210 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 243160013211 active site 243160013212 nucleophile elbow; other site 243160013213 benzoate transport; Region: 2A0115; TIGR00895 243160013214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243160013215 Cytochrome P450; Region: p450; cl12078 243160013216 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243160013217 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 243160013218 FMN-binding pocket [chemical binding]; other site 243160013219 flavin binding motif; other site 243160013220 phosphate binding motif [ion binding]; other site 243160013221 beta-alpha-beta structure motif; other site 243160013222 NAD binding pocket [chemical binding]; other site 243160013223 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243160013224 catalytic loop [active] 243160013225 iron binding site [ion binding]; other site 243160013226 H+ Antiporter protein; Region: 2A0121; TIGR00900 243160013227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160013228 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 243160013229 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 243160013230 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 243160013231 G1 box; other site 243160013232 putative GEF interaction site [polypeptide binding]; other site 243160013233 GTP/Mg2+ binding site [chemical binding]; other site 243160013234 Switch I region; other site 243160013235 G2 box; other site 243160013236 G3 box; other site 243160013237 Switch II region; other site 243160013238 G4 box; other site 243160013239 G5 box; other site 243160013240 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 243160013241 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 243160013242 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 243160013243 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 243160013244 selenocysteine synthase; Provisional; Region: PRK04311 243160013245 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 243160013246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160013247 catalytic residue [active] 243160013248 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 243160013249 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 243160013250 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243160013251 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 243160013252 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 243160013253 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 243160013254 Uncharacterized conserved protein [Function unknown]; Region: COG1434 243160013255 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 243160013256 putative active site [active] 243160013257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160013258 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160013259 substrate binding pocket [chemical binding]; other site 243160013260 membrane-bound complex binding site; other site 243160013261 hinge residues; other site 243160013262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160013263 dimer interface [polypeptide binding]; other site 243160013264 conserved gate region; other site 243160013265 putative PBP binding loops; other site 243160013266 ABC-ATPase subunit interface; other site 243160013267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243160013268 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160013269 Walker A/P-loop; other site 243160013270 ATP binding site [chemical binding]; other site 243160013271 Q-loop/lid; other site 243160013272 ABC transporter signature motif; other site 243160013273 Walker B; other site 243160013274 D-loop; other site 243160013275 H-loop/switch region; other site 243160013276 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243160013277 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243160013278 active site 243160013279 non-prolyl cis peptide bond; other site 243160013280 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 243160013281 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243160013282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160013283 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160013284 substrate binding pocket [chemical binding]; other site 243160013285 membrane-bound complex binding site; other site 243160013286 hinge residues; other site 243160013287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243160013288 Coenzyme A binding pocket [chemical binding]; other site 243160013289 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 243160013290 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 243160013291 putative active site [active] 243160013292 Zn binding site [ion binding]; other site 243160013293 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243160013294 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160013295 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160013296 trimer interface [polypeptide binding]; other site 243160013297 eyelet of channel; other site 243160013298 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160013299 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243160013300 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 243160013301 active site 243160013302 tetramer interface; other site 243160013303 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 243160013304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160013305 putative ADP-binding pocket [chemical binding]; other site 243160013306 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243160013307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243160013308 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243160013309 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 243160013310 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243160013311 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243160013312 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243160013313 NADP-binding site; other site 243160013314 homotetramer interface [polypeptide binding]; other site 243160013315 substrate binding site [chemical binding]; other site 243160013316 homodimer interface [polypeptide binding]; other site 243160013317 active site 243160013318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160013319 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160013320 NAD(P) binding site [chemical binding]; other site 243160013321 active site 243160013322 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 243160013323 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 243160013324 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243160013325 homodimer interface [polypeptide binding]; other site 243160013326 substrate-cofactor binding pocket; other site 243160013327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013328 catalytic residue [active] 243160013329 amidophosphoribosyltransferase; Provisional; Region: PRK09246 243160013330 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 243160013331 active site 243160013332 tetramer interface [polypeptide binding]; other site 243160013333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243160013334 active site 243160013335 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 243160013336 Colicin V production protein; Region: Colicin_V; pfam02674 243160013337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 243160013338 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243160013339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243160013340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243160013341 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 243160013342 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243160013343 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 243160013344 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243160013345 substrate binding site [chemical binding]; other site 243160013346 active site 243160013347 catalytic residues [active] 243160013348 heterodimer interface [polypeptide binding]; other site 243160013349 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 243160013350 DNA methylase; Region: N6_N4_Mtase; pfam01555 243160013351 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 243160013352 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243160013353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013354 catalytic residue [active] 243160013355 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 243160013356 active site 243160013357 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243160013358 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243160013359 dimerization interface 3.5A [polypeptide binding]; other site 243160013360 active site 243160013361 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 243160013362 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 243160013363 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243160013364 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 243160013365 tartrate dehydrogenase; Region: TTC; TIGR02089 243160013366 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 243160013367 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243160013368 substrate binding site [chemical binding]; other site 243160013369 Predicted small secreted protein [Function unknown]; Region: COG5510 243160013370 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 243160013371 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243160013372 substrate binding site [chemical binding]; other site 243160013373 ligand binding site [chemical binding]; other site 243160013374 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243160013375 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243160013376 active site 243160013377 non-prolyl cis peptide bond; other site 243160013378 cyclase homology domain; Region: CHD; cd07302 243160013379 nucleotidyl binding site; other site 243160013380 metal binding site [ion binding]; metal-binding site 243160013381 dimer interface [polypeptide binding]; other site 243160013382 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243160013383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243160013384 putative DNA binding site [nucleotide binding]; other site 243160013385 putative Zn2+ binding site [ion binding]; other site 243160013386 AsnC family; Region: AsnC_trans_reg; pfam01037 243160013387 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 243160013388 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 243160013389 dimer interface [polypeptide binding]; other site 243160013390 TPP-binding site [chemical binding]; other site 243160013391 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 243160013392 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 243160013393 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 243160013394 Transposase; Region: HTH_Tnp_1; pfam01527 243160013395 HTH-like domain; Region: HTH_21; pfam13276 243160013396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160013397 Integrase core domain; Region: rve; pfam00665 243160013398 Integrase core domain; Region: rve_3; pfam13683 243160013399 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 243160013400 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243160013401 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243160013402 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 243160013403 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 243160013404 dimer interface [polypeptide binding]; other site 243160013405 active site 243160013406 citrylCoA binding site [chemical binding]; other site 243160013407 NADH binding [chemical binding]; other site 243160013408 cationic pore residues; other site 243160013409 oxalacetate/citrate binding site [chemical binding]; other site 243160013410 coenzyme A binding site [chemical binding]; other site 243160013411 catalytic triad [active] 243160013412 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 243160013413 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 243160013414 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 243160013415 L-aspartate oxidase; Provisional; Region: PRK06175 243160013416 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243160013417 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 243160013418 SdhC subunit interface [polypeptide binding]; other site 243160013419 proximal heme binding site [chemical binding]; other site 243160013420 cardiolipin binding site; other site 243160013421 Iron-sulfur protein interface; other site 243160013422 proximal quinone binding site [chemical binding]; other site 243160013423 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 243160013424 Iron-sulfur protein interface; other site 243160013425 proximal quinone binding site [chemical binding]; other site 243160013426 SdhD (CybS) interface [polypeptide binding]; other site 243160013427 proximal heme binding site [chemical binding]; other site 243160013428 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243160013429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160013430 DNA-binding site [nucleotide binding]; DNA binding site 243160013431 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 243160013432 malate dehydrogenase; Provisional; Region: PRK05442 243160013433 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 243160013434 NAD(P) binding site [chemical binding]; other site 243160013435 dimer interface [polypeptide binding]; other site 243160013436 malate binding site [chemical binding]; other site 243160013437 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243160013438 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 243160013439 2-methylcitrate dehydratase; Region: prpD; TIGR02330 243160013440 aconitate hydratase; Provisional; Region: acnA; PRK12881 243160013441 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 243160013442 substrate binding site [chemical binding]; other site 243160013443 ligand binding site [chemical binding]; other site 243160013444 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 243160013445 substrate binding site [chemical binding]; other site 243160013446 haemagglutination activity domain; Region: Haemagg_act; pfam05860 243160013447 Inositol polyphosphate kinase; Region: IPK; cl12283 243160013448 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 243160013449 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 243160013450 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 243160013451 Transposase; Region: HTH_Tnp_1; pfam01527 243160013452 HTH-like domain; Region: HTH_21; pfam13276 243160013453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160013454 Integrase core domain; Region: rve; pfam00665 243160013455 Integrase core domain; Region: rve_3; pfam13683 243160013456 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 243160013457 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 243160013458 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 243160013459 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 243160013460 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243160013461 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243160013462 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 243160013463 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 243160013464 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 243160013465 active site 243160013466 metal-binding site 243160013467 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 243160013468 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243160013469 tetramer interface [polypeptide binding]; other site 243160013470 active site 243160013471 Mg2+/Mn2+ binding site [ion binding]; other site 243160013472 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 243160013473 active site 243160013474 metal-binding site 243160013475 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 243160013476 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243160013477 dimer interface [polypeptide binding]; other site 243160013478 PYR/PP interface [polypeptide binding]; other site 243160013479 TPP binding site [chemical binding]; other site 243160013480 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 243160013481 TPP-binding site [chemical binding]; other site 243160013482 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160013483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160013484 catalytic residue [active] 243160013485 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243160013486 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 243160013487 conserved cys residue [active] 243160013488 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243160013489 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 243160013490 conserved cys residue [active] 243160013491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160013492 Predicted membrane protein [Function unknown]; Region: COG1289 243160013493 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 243160013494 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 243160013495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160013496 putative substrate translocation pore; other site 243160013497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243160013498 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243160013499 DNA-binding site [nucleotide binding]; DNA binding site 243160013500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243160013501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013502 homodimer interface [polypeptide binding]; other site 243160013503 catalytic residue [active] 243160013504 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243160013505 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243160013506 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243160013507 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 243160013508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243160013509 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243160013510 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243160013511 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243160013512 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243160013513 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 243160013514 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 243160013515 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243160013516 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243160013517 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243160013518 Transglutaminase/protease-like homologues; Region: TGc; smart00460 243160013519 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243160013520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243160013521 Uncharacterized conserved protein [Function unknown]; Region: COG2308 243160013522 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 243160013523 putative FMN binding site [chemical binding]; other site 243160013524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 243160013525 Chitin binding domain; Region: Chitin_bind_3; pfam03067 243160013526 peroxiredoxin; Region: AhpC; TIGR03137 243160013527 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243160013528 dimer interface [polypeptide binding]; other site 243160013529 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243160013530 catalytic triad [active] 243160013531 peroxidatic and resolving cysteines [active] 243160013532 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 243160013533 catalytic residue [active] 243160013534 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 243160013535 catalytic residues [active] 243160013536 Transposase; Region: HTH_Tnp_1; pfam01527 243160013537 HTH-like domain; Region: HTH_21; pfam13276 243160013538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160013539 Integrase core domain; Region: rve; pfam00665 243160013540 Integrase core domain; Region: rve_3; pfam13683 243160013541 Integrase core domain; Region: rve_3; pfam13683 243160013542 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243160013543 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 243160013544 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 243160013545 acetyl-CoA synthetase; Provisional; Region: PRK00174 243160013546 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 243160013547 active site 243160013548 CoA binding site [chemical binding]; other site 243160013549 acyl-activating enzyme (AAE) consensus motif; other site 243160013550 AMP binding site [chemical binding]; other site 243160013551 acetate binding site [chemical binding]; other site 243160013552 hypothetical protein; Provisional; Region: PRK05208 243160013553 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 243160013554 Fumarase C-terminus; Region: Fumerase_C; pfam05683 243160013555 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 243160013556 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 243160013557 heme binding site [chemical binding]; other site 243160013558 ferroxidase pore; other site 243160013559 ferroxidase diiron center [ion binding]; other site 243160013560 glutamate racemase; Provisional; Region: PRK00865 243160013561 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 243160013562 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243160013563 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243160013564 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243160013565 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243160013566 Transposase domain (DUF772); Region: DUF772; pfam05598 243160013567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160013568 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160013569 DAK2 domain; Region: Dak2; pfam02734 243160013570 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 243160013571 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 243160013572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243160013573 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 243160013574 putative NAD(P) binding site [chemical binding]; other site 243160013575 catalytic Zn binding site [ion binding]; other site 243160013576 structural Zn binding site [ion binding]; other site 243160013577 short chain dehydrogenase; Provisional; Region: PRK06841 243160013578 classical (c) SDRs; Region: SDR_c; cd05233 243160013579 NAD(P) binding site [chemical binding]; other site 243160013580 active site 243160013581 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 243160013582 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243160013583 putative ligand binding site [chemical binding]; other site 243160013584 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243160013585 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 243160013586 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 243160013587 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243160013588 Walker A/P-loop; other site 243160013589 ATP binding site [chemical binding]; other site 243160013590 Q-loop/lid; other site 243160013591 ABC transporter signature motif; other site 243160013592 Walker B; other site 243160013593 D-loop; other site 243160013594 H-loop/switch region; other site 243160013595 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243160013596 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 243160013597 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 243160013598 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243160013599 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 243160013600 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160013601 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160013602 trimer interface [polypeptide binding]; other site 243160013603 eyelet of channel; other site 243160013604 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 243160013605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160013606 dimer interface [polypeptide binding]; other site 243160013607 conserved gate region; other site 243160013608 putative PBP binding loops; other site 243160013609 ABC-ATPase subunit interface; other site 243160013610 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243160013611 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 243160013612 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243160013613 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 243160013614 Walker A/P-loop; other site 243160013615 ATP binding site [chemical binding]; other site 243160013616 Q-loop/lid; other site 243160013617 ABC transporter signature motif; other site 243160013618 Walker B; other site 243160013619 D-loop; other site 243160013620 H-loop/switch region; other site 243160013621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160013622 dimer interface [polypeptide binding]; other site 243160013623 conserved gate region; other site 243160013624 putative PBP binding loops; other site 243160013625 ABC-ATPase subunit interface; other site 243160013626 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 243160013627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160013629 dimerization interface [polypeptide binding]; other site 243160013630 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 243160013631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243160013632 N-terminal plug; other site 243160013633 ligand-binding site [chemical binding]; other site 243160013634 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 243160013635 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 243160013636 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 243160013637 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243160013638 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243160013639 intersubunit interface [polypeptide binding]; other site 243160013640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243160013641 putative PBP binding regions; other site 243160013642 ABC-ATPase subunit interface; other site 243160013643 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 243160013644 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 243160013645 Walker A/P-loop; other site 243160013646 ATP binding site [chemical binding]; other site 243160013647 Q-loop/lid; other site 243160013648 ABC transporter signature motif; other site 243160013649 Walker B; other site 243160013650 D-loop; other site 243160013651 H-loop/switch region; other site 243160013652 Predicted membrane protein [Function unknown]; Region: COG2860 243160013653 UPF0126 domain; Region: UPF0126; pfam03458 243160013654 UPF0126 domain; Region: UPF0126; pfam03458 243160013655 Transglycosylase; Region: Transgly; pfam00912 243160013656 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 243160013657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243160013658 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 243160013659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013660 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 243160013661 putative dimerization interface [polypeptide binding]; other site 243160013662 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 243160013663 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 243160013664 tetramer interface [polypeptide binding]; other site 243160013665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013666 catalytic residue [active] 243160013667 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 243160013668 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243160013669 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 243160013670 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243160013671 active site lid residues [active] 243160013672 substrate binding pocket [chemical binding]; other site 243160013673 catalytic residues [active] 243160013674 substrate-Mg2+ binding site; other site 243160013675 aspartate-rich region 1; other site 243160013676 aspartate-rich region 2; other site 243160013677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160013678 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243160013679 active site 243160013680 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 243160013681 Sulfatase; Region: Sulfatase; cl17466 243160013682 Sulfatase; Region: Sulfatase; cl17466 243160013683 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243160013684 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243160013685 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243160013686 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243160013687 Uncharacterized conserved protein [Function unknown]; Region: COG5361 243160013688 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 243160013689 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 243160013690 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 243160013691 Heavy-metal-associated domain; Region: HMA; pfam00403 243160013692 metal-binding site [ion binding] 243160013693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243160013694 metal-binding site [ion binding] 243160013695 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243160013696 metal-binding site [ion binding] 243160013697 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243160013698 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243160013699 metal-binding site [ion binding] 243160013700 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243160013701 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 243160013702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243160013703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160013704 Coenzyme A binding pocket [chemical binding]; other site 243160013705 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 243160013706 MgtC family; Region: MgtC; pfam02308 243160013707 dimerization interface [polypeptide binding]; other site 243160013708 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 243160013709 putative active cleft [active] 243160013710 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 243160013711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013712 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243160013713 dimerization interface [polypeptide binding]; other site 243160013714 substrate binding pocket [chemical binding]; other site 243160013715 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 243160013716 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 243160013717 dimer interface [polypeptide binding]; other site 243160013718 ligand binding site [chemical binding]; other site 243160013719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160013720 dimer interface [polypeptide binding]; other site 243160013721 putative CheW interface [polypeptide binding]; other site 243160013722 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 243160013723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160013724 FeS/SAM binding site; other site 243160013725 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243160013726 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 243160013727 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 243160013728 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 243160013729 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 243160013730 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 243160013731 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243160013732 CoenzymeA binding site [chemical binding]; other site 243160013733 subunit interaction site [polypeptide binding]; other site 243160013734 PHB binding site; other site 243160013735 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 243160013736 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 243160013737 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 243160013738 substrate binding site [chemical binding]; other site 243160013739 ligand binding site [chemical binding]; other site 243160013740 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 243160013741 substrate binding site [chemical binding]; other site 243160013742 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 243160013743 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 243160013744 dimer interface [polypeptide binding]; other site 243160013745 active site 243160013746 citrylCoA binding site [chemical binding]; other site 243160013747 oxalacetate/citrate binding site [chemical binding]; other site 243160013748 coenzyme A binding site [chemical binding]; other site 243160013749 catalytic triad [active] 243160013750 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 243160013751 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243160013752 tetramer interface [polypeptide binding]; other site 243160013753 active site 243160013754 Mg2+/Mn2+ binding site [ion binding]; other site 243160013755 Propionate catabolism activator; Region: PrpR_N; pfam06506 243160013756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160013757 putative active site [active] 243160013758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160013759 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243160013760 Walker A motif; other site 243160013761 ATP binding site [chemical binding]; other site 243160013762 Walker B motif; other site 243160013763 arginine finger; other site 243160013764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243160013765 dimerization interface [polypeptide binding]; other site 243160013766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243160013767 dimer interface [polypeptide binding]; other site 243160013768 putative CheW interface [polypeptide binding]; other site 243160013769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243160013770 S-adenosylmethionine binding site [chemical binding]; other site 243160013771 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 243160013772 TAP-like protein; Region: Abhydrolase_4; pfam08386 243160013773 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 243160013774 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 243160013775 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 243160013776 active site 243160013777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013779 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 243160013780 putative substrate binding pocket [chemical binding]; other site 243160013781 dimerization interface [polypeptide binding]; other site 243160013782 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 243160013783 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 243160013784 putative active site [active] 243160013785 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243160013786 carboxyltransferase (CT) interaction site; other site 243160013787 biotinylation site [posttranslational modification]; other site 243160013788 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 243160013789 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243160013790 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243160013791 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243160013792 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 243160013793 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 243160013794 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 243160013795 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243160013796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243160013797 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 243160013798 dimer interface [polypeptide binding]; other site 243160013799 putative metal binding site [ion binding]; other site 243160013800 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 243160013801 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243160013802 homodimer interface [polypeptide binding]; other site 243160013803 substrate-cofactor binding pocket; other site 243160013804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160013805 catalytic residue [active] 243160013806 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243160013807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243160013808 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 243160013809 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160013810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013812 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 243160013813 putative substrate binding pocket [chemical binding]; other site 243160013814 putative dimerization interface [polypeptide binding]; other site 243160013815 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243160013816 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 243160013817 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 243160013818 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243160013819 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 243160013820 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013822 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 243160013823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013824 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 243160013825 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013826 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013827 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243160013828 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243160013829 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243160013830 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243160013831 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 243160013832 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 243160013833 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 243160013834 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 243160013835 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 243160013836 ImpE protein; Region: ImpE; pfam07024 243160013837 Protein of unknown function (DUF770); Region: DUF770; pfam05591 243160013838 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 243160013839 Protein of unknown function (DUF877); Region: DUF877; pfam05943 243160013840 Protein of unknown function (DUF796); Region: DUF796; pfam05638 243160013841 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 243160013842 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 243160013843 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 243160013844 hypothetical protein; Provisional; Region: PRK08126 243160013845 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 243160013846 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243160013847 ligand binding site [chemical binding]; other site 243160013848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013850 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243160013851 putative effector binding pocket; other site 243160013852 dimerization interface [polypeptide binding]; other site 243160013853 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 243160013854 active site 243160013855 metal binding site [ion binding]; metal-binding site 243160013856 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243160013857 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 243160013858 NADP binding site [chemical binding]; other site 243160013859 dimer interface [polypeptide binding]; other site 243160013860 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243160013861 active site 243160013862 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 243160013863 dimer interface [polypeptide binding]; other site 243160013864 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243160013865 Ligand Binding Site [chemical binding]; other site 243160013866 Molecular Tunnel; other site 243160013867 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 243160013868 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 243160013869 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243160013870 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160013871 substrate binding pocket [chemical binding]; other site 243160013872 active site 243160013873 iron coordination sites [ion binding]; other site 243160013874 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 243160013875 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 243160013876 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 243160013877 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 243160013878 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243160013879 SnoaL-like domain; Region: SnoaL_2; pfam12680 243160013880 short chain dehydrogenase; Provisional; Region: PRK07023 243160013881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243160013882 NAD(P) binding site [chemical binding]; other site 243160013883 active site 243160013884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160013885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013886 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160013887 dimerization interface [polypeptide binding]; other site 243160013888 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 243160013889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243160013890 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 243160013891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160013892 substrate binding pocket [chemical binding]; other site 243160013893 membrane-bound complex binding site; other site 243160013894 hinge residues; other site 243160013895 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 243160013896 putative di-iron ligands [ion binding]; other site 243160013897 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 243160013898 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 243160013899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160013900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243160013901 dimerization interface [polypeptide binding]; other site 243160013902 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 243160013903 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 243160013904 metal binding site [ion binding]; metal-binding site 243160013905 putative dimer interface [polypeptide binding]; other site 243160013906 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160013907 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160013908 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 243160013909 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243160013910 ATP binding site [chemical binding]; other site 243160013911 Mg++ binding site [ion binding]; other site 243160013912 motif III; other site 243160013913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243160013914 nucleotide binding region [chemical binding]; other site 243160013915 ATP-binding site [chemical binding]; other site 243160013916 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 243160013917 putative RNA binding site [nucleotide binding]; other site 243160013918 Transposase; Region: HTH_Tnp_1; pfam01527 243160013919 HTH-like domain; Region: HTH_21; pfam13276 243160013920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160013921 Integrase core domain; Region: rve; pfam00665 243160013922 Integrase core domain; Region: rve_3; pfam13683 243160013923 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243160013924 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243160013925 Bacterial transcriptional regulator; Region: IclR; pfam01614 243160013926 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243160013927 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160013928 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160013929 trimer interface [polypeptide binding]; other site 243160013930 eyelet of channel; other site 243160013931 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 243160013932 2-methylcitrate dehydratase; Region: prpD; TIGR02330 243160013933 OpgC protein; Region: OpgC_C; pfam10129 243160013934 Predicted permeases [General function prediction only]; Region: RarD; COG2962 243160013935 acylphosphatase; Provisional; Region: PRK14424 243160013936 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243160013937 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 243160013938 putative NADP binding site [chemical binding]; other site 243160013939 putative substrate binding site [chemical binding]; other site 243160013940 active site 243160013941 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 243160013942 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 243160013943 active site 243160013944 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 243160013945 LytB protein; Region: LYTB; pfam02401 243160013946 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 243160013947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243160013948 FeS/SAM binding site; other site 243160013949 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 243160013950 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 243160013951 aminotransferase; Validated; Region: PRK07046 243160013952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243160013953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243160013954 catalytic residue [active] 243160013955 Transposase domain (DUF772); Region: DUF772; pfam05598 243160013956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160013957 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160013958 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 243160013959 short chain dehydrogenase; Provisional; Region: PRK06701 243160013960 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 243160013961 NAD binding site [chemical binding]; other site 243160013962 metal binding site [ion binding]; metal-binding site 243160013963 active site 243160013964 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 243160013965 short chain dehydrogenase; Provisional; Region: PRK07109 243160013966 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 243160013967 putative NAD(P) binding site [chemical binding]; other site 243160013968 active site 243160013969 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243160013970 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 243160013971 putative ADP-binding pocket [chemical binding]; other site 243160013972 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 243160013973 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243160013974 NAD binding site [chemical binding]; other site 243160013975 putative substrate binding site 2 [chemical binding]; other site 243160013976 putative substrate binding site 1 [chemical binding]; other site 243160013977 active site 243160013978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160013979 PAS domain; Region: PAS_9; pfam13426 243160013980 putative active site [active] 243160013981 heme pocket [chemical binding]; other site 243160013982 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243160013983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160013984 putative active site [active] 243160013985 heme pocket [chemical binding]; other site 243160013986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160013987 dimer interface [polypeptide binding]; other site 243160013988 phosphorylation site [posttranslational modification] 243160013989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160013990 ATP binding site [chemical binding]; other site 243160013991 Mg2+ binding site [ion binding]; other site 243160013992 G-X-G motif; other site 243160013993 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243160013994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160013995 active site 243160013996 phosphorylation site [posttranslational modification] 243160013997 intermolecular recognition site; other site 243160013998 dimerization interface [polypeptide binding]; other site 243160013999 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243160014000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160014001 active site 243160014002 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243160014003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160014004 active site 243160014005 phosphorylation site [posttranslational modification] 243160014006 intermolecular recognition site; other site 243160014007 dimerization interface [polypeptide binding]; other site 243160014008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160014009 Walker A motif; other site 243160014010 ATP binding site [chemical binding]; other site 243160014011 Walker B motif; other site 243160014012 arginine finger; other site 243160014013 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243160014014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243160014015 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243160014016 Walker A motif; other site 243160014017 ATP binding site [chemical binding]; other site 243160014018 Walker B motif; other site 243160014019 arginine finger; other site 243160014020 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243160014021 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160014022 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160014023 putative active site [active] 243160014024 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243160014025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243160014026 active site 243160014027 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 243160014028 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 243160014029 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243160014030 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243160014031 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243160014032 putative active site [active] 243160014033 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 243160014034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243160014035 active site 243160014036 motif I; other site 243160014037 motif II; other site 243160014038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243160014039 classical (c) SDRs; Region: SDR_c; cd05233 243160014040 NAD(P) binding site [chemical binding]; other site 243160014041 active site 243160014042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160014043 Response regulator receiver domain; Region: Response_reg; pfam00072 243160014044 active site 243160014045 phosphorylation site [posttranslational modification] 243160014046 intermolecular recognition site; other site 243160014047 dimerization interface [polypeptide binding]; other site 243160014048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243160014049 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 243160014050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160014051 Walker A/P-loop; other site 243160014052 ATP binding site [chemical binding]; other site 243160014053 Q-loop/lid; other site 243160014054 ABC transporter signature motif; other site 243160014055 Walker B; other site 243160014056 D-loop; other site 243160014057 H-loop/switch region; other site 243160014058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 243160014059 BON domain; Region: BON; pfam04972 243160014060 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 243160014061 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 243160014062 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 243160014063 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 243160014064 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243160014065 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243160014066 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243160014067 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243160014068 active site 243160014069 non-prolyl cis peptide bond; other site 243160014070 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 243160014071 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 243160014072 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 243160014073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160014074 putative substrate translocation pore; other site 243160014075 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 243160014076 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243160014077 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 243160014078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160014079 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243160014080 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243160014081 E3 interaction surface; other site 243160014082 lipoyl attachment site [posttranslational modification]; other site 243160014083 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 243160014084 e3 binding domain; Region: E3_binding; pfam02817 243160014085 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243160014086 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243160014087 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243160014088 alpha subunit interface [polypeptide binding]; other site 243160014089 TPP binding site [chemical binding]; other site 243160014090 heterodimer interface [polypeptide binding]; other site 243160014091 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243160014092 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 243160014093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 243160014094 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243160014095 tetramer interface [polypeptide binding]; other site 243160014096 TPP-binding site [chemical binding]; other site 243160014097 heterodimer interface [polypeptide binding]; other site 243160014098 phosphorylation loop region [posttranslational modification] 243160014099 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243160014100 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243160014101 putative hydrophobic ligand binding site [chemical binding]; other site 243160014102 protein interface [polypeptide binding]; other site 243160014103 gate; other site 243160014104 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 243160014105 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 243160014106 hydrophobic ligand binding site; other site 243160014107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243160014108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243160014109 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 243160014110 substrate binding pocket [chemical binding]; other site 243160014111 dimerization interface [polypeptide binding]; other site 243160014112 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243160014113 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243160014114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243160014115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243160014116 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 243160014117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243160014118 nucleophile elbow; other site 243160014119 Patatin phospholipase; Region: DUF3734; pfam12536 243160014120 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 243160014121 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 243160014122 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 243160014123 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 243160014124 active site 243160014125 dimer interface [polypeptide binding]; other site 243160014126 effector binding site; other site 243160014127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 243160014128 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243160014129 AAA domain; Region: AAA_33; pfam13671 243160014130 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243160014131 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243160014132 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243160014133 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 243160014134 FOG: CBS domain [General function prediction only]; Region: COG0517 243160014135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 243160014136 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243160014137 putative FMN binding site [chemical binding]; other site 243160014138 NADPH bind site [chemical binding]; other site 243160014139 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243160014140 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 243160014141 putative dimer interface [polypeptide binding]; other site 243160014142 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160014143 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160014144 trimer interface [polypeptide binding]; other site 243160014145 eyelet of channel; other site 243160014146 putative acyl-CoA synthetase; Provisional; Region: PRK06018 243160014147 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243160014148 acyl-activating enzyme (AAE) consensus motif; other site 243160014149 AMP binding site [chemical binding]; other site 243160014150 active site 243160014151 CoA binding site [chemical binding]; other site 243160014152 AAA ATPase domain; Region: AAA_16; pfam13191 243160014153 AAA domain; Region: AAA_22; pfam13401 243160014154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160014155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160014156 DNA binding residues [nucleotide binding] 243160014157 dimerization interface [polypeptide binding]; other site 243160014158 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 243160014159 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 243160014160 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 243160014161 NADP binding site [chemical binding]; other site 243160014162 dimer interface [polypeptide binding]; other site 243160014163 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243160014164 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243160014165 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 243160014166 benzoate transport; Region: 2A0115; TIGR00895 243160014167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243160014168 putative substrate translocation pore; other site 243160014169 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243160014170 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160014171 molybdopterin cofactor binding site; other site 243160014172 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243160014173 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243160014174 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 243160014175 putative molybdopterin cofactor binding site; other site 243160014176 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 243160014177 4Fe-4S binding domain; Region: Fer4; pfam00037 243160014178 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 243160014179 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243160014180 putative active site [active] 243160014181 putative metal binding site [ion binding]; other site 243160014182 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 243160014183 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 243160014184 Transglycosylase; Region: Transgly; pfam00912 243160014185 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 243160014186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243160014187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243160014188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243160014189 catalytic residues [active] 243160014190 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 243160014191 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 243160014192 trimer interface [polypeptide binding]; other site 243160014193 eyelet of channel; other site 243160014194 amidase; Provisional; Region: PRK08137 243160014195 Amidase; Region: Amidase; cl11426 243160014196 putative acetyltransferase YhhY; Provisional; Region: PRK10140 243160014197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160014198 Coenzyme A binding pocket [chemical binding]; other site 243160014199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243160014200 putative acetyltransferase YhhY; Provisional; Region: PRK10140 243160014201 Coenzyme A binding pocket [chemical binding]; other site 243160014202 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243160014203 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243160014204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243160014205 D-loop; other site 243160014206 H-loop/switch region; other site 243160014207 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243160014208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 243160014209 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243160014210 Histidine kinase; Region: HisKA_3; pfam07730 243160014211 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 243160014212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243160014213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160014214 active site 243160014215 phosphorylation site [posttranslational modification] 243160014216 intermolecular recognition site; other site 243160014217 dimerization interface [polypeptide binding]; other site 243160014218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243160014219 DNA binding residues [nucleotide binding] 243160014220 dimerization interface [polypeptide binding]; other site 243160014221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 243160014222 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243160014223 HTH-like domain; Region: HTH_21; pfam13276 243160014224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 243160014225 Integrase core domain; Region: rve; pfam00665 243160014226 Integrase core domain; Region: rve_3; pfam13683 243160014227 Transposase; Region: HTH_Tnp_1; pfam01527 243160014228 Transposase domain (DUF772); Region: DUF772; pfam05598 243160014229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160014230 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160014231 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 243160014232 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 243160014233 PAS domain; Region: PAS_9; pfam13426 243160014234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160014235 putative active site [active] 243160014236 heme pocket [chemical binding]; other site 243160014237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160014238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160014239 metal binding site [ion binding]; metal-binding site 243160014240 active site 243160014241 I-site; other site 243160014242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243160014243 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 243160014244 Lipase (class 2); Region: Lipase_2; pfam01674 243160014245 PGAP1-like protein; Region: PGAP1; pfam07819 243160014246 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 243160014247 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 243160014248 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 243160014249 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 243160014250 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243160014251 FtsX-like permease family; Region: FtsX; pfam02687 243160014252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243160014253 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243160014254 Walker A/P-loop; other site 243160014255 ATP binding site [chemical binding]; other site 243160014256 Q-loop/lid; other site 243160014257 ABC transporter signature motif; other site 243160014258 Walker B; other site 243160014259 D-loop; other site 243160014260 H-loop/switch region; other site 243160014261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243160014262 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 243160014263 Cytochrome P450; Region: p450; cl12078 243160014264 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243160014265 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243160014266 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243160014267 putative NADP binding site [chemical binding]; other site 243160014268 active site 243160014269 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 243160014270 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 243160014271 putative NAD(P) binding site [chemical binding]; other site 243160014272 active site 243160014273 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243160014274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 243160014275 active site 243160014276 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243160014277 active site 243160014278 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243160014279 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243160014280 putative NADP binding site [chemical binding]; other site 243160014281 active site 243160014282 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243160014283 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243160014284 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243160014285 VacJ like lipoprotein; Region: VacJ; cl01073 243160014286 hypothetical protein; Provisional; Region: PRK07483 243160014287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243160014288 inhibitor-cofactor binding pocket; inhibition site 243160014289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243160014290 catalytic residue [active] 243160014291 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 243160014292 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 243160014293 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243160014294 Walker A/P-loop; other site 243160014295 ATP binding site [chemical binding]; other site 243160014296 Q-loop/lid; other site 243160014297 ABC transporter signature motif; other site 243160014298 Walker B; other site 243160014299 D-loop; other site 243160014300 H-loop/switch region; other site 243160014301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243160014302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243160014303 dimer interface [polypeptide binding]; other site 243160014304 conserved gate region; other site 243160014305 putative PBP binding loops; other site 243160014306 ABC-ATPase subunit interface; other site 243160014307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243160014308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243160014309 substrate binding pocket [chemical binding]; other site 243160014310 membrane-bound complex binding site; other site 243160014311 hinge residues; other site 243160014312 hypothetical protein; Provisional; Region: PRK07077 243160014313 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 243160014314 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 243160014315 Active site cavity [active] 243160014316 catalytic acid [active] 243160014317 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243160014318 active site lid residues [active] 243160014319 substrate binding pocket [chemical binding]; other site 243160014320 catalytic residues [active] 243160014321 substrate-Mg2+ binding site; other site 243160014322 aspartate-rich region 1; other site 243160014323 aspartate-rich region 2; other site 243160014324 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243160014325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243160014326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243160014327 PAS fold; Region: PAS_4; pfam08448 243160014328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243160014329 putative active site [active] 243160014330 heme pocket [chemical binding]; other site 243160014331 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243160014332 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243160014333 metal binding site [ion binding]; metal-binding site 243160014334 active site 243160014335 I-site; other site 243160014336 Response regulator receiver domain; Region: Response_reg; pfam00072 243160014337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160014338 active site 243160014339 phosphorylation site [posttranslational modification] 243160014340 intermolecular recognition site; other site 243160014341 dimerization interface [polypeptide binding]; other site 243160014342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243160014343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243160014344 dimer interface [polypeptide binding]; other site 243160014345 phosphorylation site [posttranslational modification] 243160014346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243160014347 ATP binding site [chemical binding]; other site 243160014348 Mg2+ binding site [ion binding]; other site 243160014349 G-X-G motif; other site 243160014350 Response regulator receiver domain; Region: Response_reg; pfam00072 243160014351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243160014352 active site 243160014353 phosphorylation site [posttranslational modification] 243160014354 intermolecular recognition site; other site 243160014355 dimerization interface [polypeptide binding]; other site 243160014356 Predicted flavoprotein [General function prediction only]; Region: COG0431 243160014357 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243160014358 RNA polymerase sigma factor; Provisional; Region: PRK12545 243160014359 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243160014360 DNA binding residues [nucleotide binding] 243160014361 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 243160014362 ArsC family; Region: ArsC; pfam03960 243160014363 catalytic residues [active] 243160014364 ParA-like protein; Provisional; Region: PHA02518 243160014365 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243160014366 P-loop; other site 243160014367 Magnesium ion binding site [ion binding]; other site 243160014368 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 243160014369 ParB-like nuclease domain; Region: ParB; smart00470 243160014370 Transposase domain (DUF772); Region: DUF772; pfam05598 243160014371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243160014372 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243160014373 Initiator Replication protein; Region: Rep_3; pfam01051