-- dump date 20140619_013923 -- class Genbank::misc_feature -- table misc_feature_note -- id note 320388000001 HTH-like domain; Region: HTH_21; pfam13276 320388000002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000003 Integrase core domain; Region: rve; pfam00665 320388000004 Integrase core domain; Region: rve_3; pfam13683 320388000005 Transposase; Region: HTH_Tnp_1; pfam01527 320388000006 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320388000007 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 320388000008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388000009 dimerization interface [polypeptide binding]; other site 320388000010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388000011 dimer interface [polypeptide binding]; other site 320388000012 phosphorylation site [posttranslational modification] 320388000013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388000014 ATP binding site [chemical binding]; other site 320388000015 Mg2+ binding site [ion binding]; other site 320388000016 G-X-G motif; other site 320388000017 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 320388000018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388000019 active site 320388000020 phosphorylation site [posttranslational modification] 320388000021 intermolecular recognition site; other site 320388000022 dimerization interface [polypeptide binding]; other site 320388000023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388000024 DNA binding site [nucleotide binding] 320388000025 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 320388000026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388000027 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 320388000028 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388000029 Outer membrane efflux protein; Region: OEP; pfam02321 320388000030 Outer membrane efflux protein; Region: OEP; pfam02321 320388000031 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 320388000032 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 320388000033 putative deacylase active site [active] 320388000034 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 320388000035 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 320388000036 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 320388000037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388000038 Walker A motif; other site 320388000039 ATP binding site [chemical binding]; other site 320388000040 Walker B motif; other site 320388000041 arginine finger; other site 320388000042 Peptidase family M41; Region: Peptidase_M41; pfam01434 320388000043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388000044 active site 320388000045 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388000046 Predicted transcriptional regulator [Transcription]; Region: COG2345 320388000047 MarR family; Region: MarR_2; pfam12802 320388000048 Transcriptional regulator PadR-like family; Region: PadR; cl17335 320388000049 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 320388000050 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320388000051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388000052 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388000053 multidrug efflux protein; Reviewed; Region: PRK09579 320388000054 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320388000055 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 320388000056 dimerization interface [polypeptide binding]; other site 320388000057 active site 320388000058 FOG: WD40 repeat [General function prediction only]; Region: COG2319 320388000059 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 320388000060 structural tetrad; other site 320388000061 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 320388000062 structural tetrad; other site 320388000063 FOG: WD40 repeat [General function prediction only]; Region: COG2319 320388000064 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388000065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388000066 S-adenosylmethionine binding site [chemical binding]; other site 320388000067 Phage integrase protein; Region: DUF3701; pfam12482 320388000068 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 320388000069 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 320388000070 Int/Topo IB signature motif; other site 320388000071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 320388000072 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 320388000073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 320388000074 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 320388000075 Transposase; Region: HTH_Tnp_1; pfam01527 320388000076 HTH-like domain; Region: HTH_21; pfam13276 320388000077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000078 Integrase core domain; Region: rve; pfam00665 320388000079 Integrase core domain; Region: rve_3; pfam13683 320388000080 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320388000081 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320388000082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320388000083 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 320388000084 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 320388000085 ligand binding site [chemical binding]; other site 320388000086 short chain dehydrogenase; Provisional; Region: PRK07074 320388000087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388000088 NAD(P) binding site [chemical binding]; other site 320388000089 active site 320388000090 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 320388000091 putative cation:proton antiport protein; Provisional; Region: PRK10669 320388000092 TrkA-N domain; Region: TrkA_N; pfam02254 320388000093 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320388000094 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320388000095 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 320388000096 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 320388000097 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320388000098 dimer interface [polypeptide binding]; other site 320388000099 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 320388000100 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 320388000101 Cl binding site [ion binding]; other site 320388000102 oligomer interface [polypeptide binding]; other site 320388000103 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320388000104 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320388000105 Electron transfer DM13; Region: DM13; pfam10517 320388000106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320388000107 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320388000108 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 320388000109 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320388000110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000111 dimer interface [polypeptide binding]; other site 320388000112 conserved gate region; other site 320388000113 putative PBP binding loops; other site 320388000114 ABC-ATPase subunit interface; other site 320388000115 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320388000116 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 320388000117 inhibitor binding site; inhibition site 320388000118 catalytic Zn binding site [ion binding]; other site 320388000119 structural Zn binding site [ion binding]; other site 320388000120 NADP binding site [chemical binding]; other site 320388000121 tetramer interface [polypeptide binding]; other site 320388000122 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320388000123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388000124 Walker A/P-loop; other site 320388000125 ATP binding site [chemical binding]; other site 320388000126 Q-loop/lid; other site 320388000127 ABC transporter signature motif; other site 320388000128 Walker B; other site 320388000129 D-loop; other site 320388000130 H-loop/switch region; other site 320388000131 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388000132 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320388000133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388000134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388000135 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 320388000136 N- and C-terminal domain interface [polypeptide binding]; other site 320388000137 D-xylulose kinase; Region: XylB; TIGR01312 320388000138 active site 320388000139 MgATP binding site [chemical binding]; other site 320388000140 catalytic site [active] 320388000141 metal binding site [ion binding]; metal-binding site 320388000142 xylulose binding site [chemical binding]; other site 320388000143 homodimer interface [polypeptide binding]; other site 320388000144 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320388000145 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320388000146 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320388000147 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320388000148 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320388000149 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 320388000150 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 320388000151 [4Fe-4S] binding site [ion binding]; other site 320388000152 molybdopterin cofactor binding site; other site 320388000153 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 320388000154 molybdopterin cofactor binding site; other site 320388000155 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 320388000156 Flavodoxin; Region: Flavodoxin_1; pfam00258 320388000157 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 320388000158 FAD binding pocket [chemical binding]; other site 320388000159 FAD binding motif [chemical binding]; other site 320388000160 catalytic residues [active] 320388000161 NAD binding pocket [chemical binding]; other site 320388000162 phosphate binding motif [ion binding]; other site 320388000163 beta-alpha-beta structure motif; other site 320388000164 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 320388000165 nitrite reductase subunit NirD; Provisional; Region: PRK14989 320388000166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388000167 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320388000168 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388000169 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 320388000170 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 320388000171 active site 320388000172 SAM binding site [chemical binding]; other site 320388000173 homodimer interface [polypeptide binding]; other site 320388000174 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 320388000175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388000176 active site 320388000177 phosphorylation site [posttranslational modification] 320388000178 intermolecular recognition site; other site 320388000179 dimerization interface [polypeptide binding]; other site 320388000180 ANTAR domain; Region: ANTAR; pfam03861 320388000181 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 320388000182 NMT1-like family; Region: NMT1_2; pfam13379 320388000183 GTP cyclohydrolase I; Reviewed; Region: PRK12606 320388000184 GTP cyclohydrolase I; Provisional; Region: PLN03044 320388000185 active site 320388000186 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320388000187 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 320388000188 active site 320388000189 Zn binding site [ion binding]; other site 320388000190 allantoate amidohydrolase; Reviewed; Region: PRK12893 320388000191 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 320388000192 active site 320388000193 metal binding site [ion binding]; metal-binding site 320388000194 dimer interface [polypeptide binding]; other site 320388000195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000196 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388000197 putative substrate translocation pore; other site 320388000198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388000199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388000201 dimerization interface [polypeptide binding]; other site 320388000202 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 320388000203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388000204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000205 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320388000206 putative effector binding pocket; other site 320388000207 putative dimerization interface [polypeptide binding]; other site 320388000208 short chain dehydrogenase; Provisional; Region: PRK12937 320388000209 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 320388000210 NADP binding site [chemical binding]; other site 320388000211 homodimer interface [polypeptide binding]; other site 320388000212 active site 320388000213 substrate binding site [chemical binding]; other site 320388000214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388000215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388000216 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320388000217 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320388000218 NAD(P) binding site [chemical binding]; other site 320388000219 substrate binding site [chemical binding]; other site 320388000220 dimer interface [polypeptide binding]; other site 320388000221 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 320388000222 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 320388000223 dimer interface [polypeptide binding]; other site 320388000224 active site 320388000225 metal binding site [ion binding]; metal-binding site 320388000226 Peptidase M66; Region: Peptidase_M66; pfam10462 320388000227 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 320388000228 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 320388000229 Domain of unknown function (DUF802); Region: DUF802; pfam05650 320388000230 hypothetical protein; Provisional; Region: PRK09040 320388000231 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388000232 ligand binding site [chemical binding]; other site 320388000233 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 320388000234 Condensation domain; Region: Condensation; pfam00668 320388000235 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388000236 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320388000237 acyl-activating enzyme (AAE) consensus motif; other site 320388000238 AMP binding site [chemical binding]; other site 320388000239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000240 MbtH-like protein; Region: MbtH; pfam03621 320388000241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388000242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 320388000243 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320388000244 Transposase domain (DUF772); Region: DUF772; pfam05598 320388000245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388000246 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388000247 Transposase; Region: HTH_Tnp_1; pfam01527 320388000248 HTH-like domain; Region: HTH_21; pfam13276 320388000249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000250 Integrase core domain; Region: rve; pfam00665 320388000251 Integrase core domain; Region: rve_3; pfam13683 320388000252 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320388000253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388000254 active site 320388000255 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 320388000256 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 320388000257 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320388000258 putative ligand binding site [chemical binding]; other site 320388000259 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388000260 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320388000261 Walker A/P-loop; other site 320388000262 ATP binding site [chemical binding]; other site 320388000263 Q-loop/lid; other site 320388000264 ABC transporter signature motif; other site 320388000265 Walker B; other site 320388000266 D-loop; other site 320388000267 H-loop/switch region; other site 320388000268 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320388000269 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 320388000270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388000271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320388000272 TM-ABC transporter signature motif; other site 320388000273 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 320388000274 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388000275 N-terminal plug; other site 320388000276 ligand-binding site [chemical binding]; other site 320388000277 fec operon regulator FecR; Reviewed; Region: PRK09774 320388000278 FecR protein; Region: FecR; pfam04773 320388000279 RNA polymerase sigma factor; Provisional; Region: PRK12528 320388000280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388000281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388000282 DNA binding residues [nucleotide binding] 320388000283 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320388000284 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320388000285 YceI-like domain; Region: YceI; pfam04264 320388000286 RNA polymerase sigma factor; Provisional; Region: PRK12547 320388000287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388000288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388000289 DNA binding residues [nucleotide binding] 320388000290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388000291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388000292 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320388000293 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 320388000294 CAAX protease self-immunity; Region: Abi; pfam02517 320388000295 MarC family integral membrane protein; Region: MarC; cl00919 320388000296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388000297 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 320388000298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388000299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388000301 putative effector binding pocket; other site 320388000302 dimerization interface [polypeptide binding]; other site 320388000303 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 320388000304 HPP family; Region: HPP; pfam04982 320388000305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 320388000306 MarR family; Region: MarR_2; pfam12802 320388000307 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320388000308 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 320388000309 Cl- selectivity filter; other site 320388000310 Cl- binding residues [ion binding]; other site 320388000311 pore gating glutamate residue; other site 320388000312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 320388000313 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388000314 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 320388000315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000316 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000317 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000318 active site 320388000319 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320388000320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388000321 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320388000322 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000323 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000324 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320388000325 active site 320388000326 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320388000327 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320388000328 putative NADP binding site [chemical binding]; other site 320388000329 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320388000330 active site 320388000331 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388000332 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320388000333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000334 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000336 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000337 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388000339 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000340 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000341 active site 320388000342 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320388000343 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320388000344 putative NADP binding site [chemical binding]; other site 320388000345 KR domain; Region: KR; pfam08659 320388000346 active site 320388000347 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000348 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000349 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000350 active site 320388000351 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000352 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000353 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000354 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000355 active site 320388000356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388000357 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320388000358 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388000359 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000361 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000362 active site 320388000363 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000364 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320388000365 KR domain; Region: KR; pfam08659 320388000366 putative NADP binding site [chemical binding]; other site 320388000367 active site 320388000368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000369 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 320388000370 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 320388000371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388000372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388000373 catalytic residue [active] 320388000374 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000376 active site 320388000377 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000378 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000379 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320388000380 active site 320388000381 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388000382 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388000383 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320388000384 active site 320388000385 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320388000386 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320388000387 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320388000388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388000389 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388000390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388000391 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 320388000392 substrate binding site [chemical binding]; other site 320388000393 oxyanion hole (OAH) forming residues; other site 320388000394 trimer interface [polypeptide binding]; other site 320388000395 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 320388000396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388000397 substrate binding site [chemical binding]; other site 320388000398 oxyanion hole (OAH) forming residues; other site 320388000399 trimer interface [polypeptide binding]; other site 320388000400 acyl carrier protein; Validated; Region: PRK07117 320388000401 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 320388000402 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 320388000403 dimer interface [polypeptide binding]; other site 320388000404 active site 320388000405 TPR repeat; Region: TPR_11; pfam13414 320388000406 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320388000407 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320388000408 iron-sulfur cluster [ion binding]; other site 320388000409 [2Fe-2S] cluster binding site [ion binding]; other site 320388000410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320388000411 hydrophobic ligand binding site; other site 320388000412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388000414 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388000415 S-adenosylmethionine binding site [chemical binding]; other site 320388000416 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 320388000417 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 320388000418 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 320388000419 tetramer interface [polypeptide binding]; other site 320388000420 heme binding pocket [chemical binding]; other site 320388000421 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 320388000422 LytTr DNA-binding domain; Region: LytTR; smart00850 320388000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388000424 active site 320388000425 phosphorylation site [posttranslational modification] 320388000426 intermolecular recognition site; other site 320388000427 dimerization interface [polypeptide binding]; other site 320388000428 Transposase; Region: HTH_Tnp_1; pfam01527 320388000429 HTH-like domain; Region: HTH_21; pfam13276 320388000430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000431 Integrase core domain; Region: rve; pfam00665 320388000432 Integrase core domain; Region: rve_3; pfam13683 320388000433 Histidine kinase; Region: His_kinase; pfam06580 320388000434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388000435 ATP binding site [chemical binding]; other site 320388000436 Mg2+ binding site [ion binding]; other site 320388000437 G-X-G motif; other site 320388000438 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 320388000439 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320388000440 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 320388000441 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 320388000442 putative active site [active] 320388000443 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320388000444 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388000445 Walker A/P-loop; other site 320388000446 ATP binding site [chemical binding]; other site 320388000447 Q-loop/lid; other site 320388000448 ABC transporter signature motif; other site 320388000449 Walker B; other site 320388000450 D-loop; other site 320388000451 H-loop/switch region; other site 320388000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000453 dimer interface [polypeptide binding]; other site 320388000454 conserved gate region; other site 320388000455 putative PBP binding loops; other site 320388000456 ABC-ATPase subunit interface; other site 320388000457 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000459 dimer interface [polypeptide binding]; other site 320388000460 conserved gate region; other site 320388000461 putative PBP binding loops; other site 320388000462 ABC-ATPase subunit interface; other site 320388000463 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 320388000464 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388000465 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388000466 trimer interface [polypeptide binding]; other site 320388000467 eyelet of channel; other site 320388000468 Predicted membrane protein [Function unknown]; Region: COG2259 320388000469 Cytochrome c; Region: Cytochrom_C; pfam00034 320388000470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388000471 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388000472 Cytochrome c; Region: Cytochrom_C; pfam00034 320388000473 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 320388000474 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388000475 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 320388000476 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 320388000477 active site 320388000478 catalytic triad [active] 320388000479 magnesium-transporting ATPase; Provisional; Region: PRK15122 320388000480 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 320388000481 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320388000482 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 320388000483 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320388000484 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 320388000485 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 320388000486 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388000487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388000488 DNA-binding site [nucleotide binding]; DNA binding site 320388000489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388000491 homodimer interface [polypeptide binding]; other site 320388000492 catalytic residue [active] 320388000493 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 320388000494 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 320388000495 putative molybdopterin cofactor binding site [chemical binding]; other site 320388000496 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 320388000497 putative molybdopterin cofactor binding site; other site 320388000498 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 320388000499 Predicted membrane protein [Function unknown]; Region: COG4682 320388000500 yiaA/B two helix domain; Region: YiaAB; pfam05360 320388000501 yiaA/B two helix domain; Region: YiaAB; pfam05360 320388000502 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 320388000503 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320388000504 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 320388000505 Cupin; Region: Cupin_1; smart00835 320388000506 Cupin; Region: Cupin_1; smart00835 320388000507 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 320388000508 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320388000509 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 320388000510 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 320388000511 catalytic triad [active] 320388000512 putative active site [active] 320388000513 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 320388000514 Autotransporter beta-domain; Region: Autotransporter; smart00869 320388000515 PAAR motif; Region: PAAR_motif; pfam05488 320388000516 RHS Repeat; Region: RHS_repeat; cl11982 320388000517 RHS Repeat; Region: RHS_repeat; pfam05593 320388000518 RHS Repeat; Region: RHS_repeat; cl11982 320388000519 RHS Repeat; Region: RHS_repeat; pfam05593 320388000520 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320388000521 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320388000522 RHS Repeat; Region: RHS_repeat; pfam05593 320388000523 RHS Repeat; Region: RHS_repeat; cl11982 320388000524 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320388000525 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 320388000526 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320388000527 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388000528 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388000529 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 320388000530 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388000531 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388000532 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 320388000533 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 320388000534 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 320388000535 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 320388000536 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 320388000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000538 dimer interface [polypeptide binding]; other site 320388000539 conserved gate region; other site 320388000540 putative PBP binding loops; other site 320388000541 ABC-ATPase subunit interface; other site 320388000542 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 320388000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000544 dimer interface [polypeptide binding]; other site 320388000545 conserved gate region; other site 320388000546 putative PBP binding loops; other site 320388000547 ABC-ATPase subunit interface; other site 320388000548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 320388000549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388000550 Walker A/P-loop; other site 320388000551 ATP binding site [chemical binding]; other site 320388000552 Q-loop/lid; other site 320388000553 ABC transporter signature motif; other site 320388000554 Walker B; other site 320388000555 D-loop; other site 320388000556 H-loop/switch region; other site 320388000557 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 320388000558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388000559 Walker A/P-loop; other site 320388000560 ATP binding site [chemical binding]; other site 320388000561 Q-loop/lid; other site 320388000562 ABC transporter signature motif; other site 320388000563 Walker B; other site 320388000564 D-loop; other site 320388000565 H-loop/switch region; other site 320388000566 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388000567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000568 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320388000569 substrate binding pocket [chemical binding]; other site 320388000570 dimerization interface [polypeptide binding]; other site 320388000571 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 320388000572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320388000573 Peptidase family M23; Region: Peptidase_M23; pfam01551 320388000574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388000575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000576 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 320388000577 putative dimerization interface [polypeptide binding]; other site 320388000578 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388000579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388000580 trimer interface [polypeptide binding]; other site 320388000581 eyelet of channel; other site 320388000582 OpgC protein; Region: OpgC_C; pfam10129 320388000583 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 320388000584 Putative esterase; Region: Esterase; pfam00756 320388000585 ornithine cyclodeaminase; Validated; Region: PRK07340 320388000586 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 320388000587 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388000588 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320388000589 Ion channel; Region: Ion_trans_2; pfam07885 320388000590 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 320388000591 TrkA-N domain; Region: TrkA_N; pfam02254 320388000592 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320388000593 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320388000594 BetR domain; Region: BetR; pfam08667 320388000595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388000596 active site 320388000597 phosphorylation site [posttranslational modification] 320388000598 intermolecular recognition site; other site 320388000599 dimerization interface [polypeptide binding]; other site 320388000600 Family description; Region: UvrD_C_2; pfam13538 320388000601 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320388000602 Tar ligand binding domain homologue; Region: TarH; pfam02203 320388000603 dimer interface [polypeptide binding]; other site 320388000604 ligand binding site [chemical binding]; other site 320388000605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388000606 dimerization interface [polypeptide binding]; other site 320388000607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388000608 dimer interface [polypeptide binding]; other site 320388000609 putative CheW interface [polypeptide binding]; other site 320388000610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000611 putative substrate translocation pore; other site 320388000612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000613 putative substrate translocation pore; other site 320388000614 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 320388000615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388000616 Coenzyme A binding pocket [chemical binding]; other site 320388000617 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 320388000618 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 320388000619 DNA binding residues [nucleotide binding] 320388000620 putative dimer interface [polypeptide binding]; other site 320388000621 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 320388000622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388000623 substrate binding pocket [chemical binding]; other site 320388000624 membrane-bound complex binding site; other site 320388000625 hinge residues; other site 320388000626 YhhN-like protein; Region: YhhN; pfam07947 320388000627 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 320388000628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 320388000629 Transposase; Region: HTH_Tnp_1; pfam01527 320388000630 HTH-like domain; Region: HTH_21; pfam13276 320388000631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000632 Integrase core domain; Region: rve; pfam00665 320388000633 Integrase core domain; Region: rve_3; pfam13683 320388000634 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 320388000635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388000636 Predicted transcriptional regulator [Transcription]; Region: COG1959 320388000637 Transcriptional regulator; Region: Rrf2; pfam02082 320388000638 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 320388000639 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 320388000640 methionine gamma-lyase; Validated; Region: PRK07049 320388000641 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 320388000642 homodimer interface [polypeptide binding]; other site 320388000643 substrate-cofactor binding pocket; other site 320388000644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388000645 catalytic residue [active] 320388000646 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388000647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388000648 dimerization interface [polypeptide binding]; other site 320388000649 putative DNA binding site [nucleotide binding]; other site 320388000650 putative Zn2+ binding site [ion binding]; other site 320388000651 AsnC family; Region: AsnC_trans_reg; pfam01037 320388000652 amidase; Provisional; Region: PRK07486 320388000653 Amidase; Region: Amidase; cl11426 320388000654 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320388000655 Ligand Binding Site [chemical binding]; other site 320388000656 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 320388000657 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 320388000658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388000659 ligand binding site [chemical binding]; other site 320388000660 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388000661 trimer interface [polypeptide binding]; other site 320388000662 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388000663 trimer interface [polypeptide binding]; other site 320388000664 Haemagglutinin; Region: HIM; pfam05662 320388000665 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388000666 trimer interface [polypeptide binding]; other site 320388000667 Haemagglutinin; Region: HIM; pfam05662 320388000668 Haemagglutinin; Region: HIM; pfam05662 320388000669 YadA-like C-terminal region; Region: YadA; pfam03895 320388000670 benzoate transport; Region: 2A0115; TIGR00895 320388000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000672 putative substrate translocation pore; other site 320388000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000674 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 320388000675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388000676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388000677 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 320388000678 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 320388000679 active site 320388000680 metal binding site [ion binding]; metal-binding site 320388000681 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 320388000682 putative active site [active] 320388000683 putative metal binding site [ion binding]; other site 320388000684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388000685 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 320388000686 NAD(P) binding site [chemical binding]; other site 320388000687 catalytic residues [active] 320388000688 L-aspartate dehydrogenase; Provisional; Region: PRK13303 320388000689 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 320388000690 Domain of unknown function DUF108; Region: DUF108; pfam01958 320388000691 hypothetical protein; Provisional; Region: PRK07064 320388000692 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388000693 PYR/PP interface [polypeptide binding]; other site 320388000694 dimer interface [polypeptide binding]; other site 320388000695 TPP binding site [chemical binding]; other site 320388000696 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388000697 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 320388000698 TPP-binding site [chemical binding]; other site 320388000699 short chain dehydrogenase; Provisional; Region: PRK07062 320388000700 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 320388000701 putative NAD(P) binding site [chemical binding]; other site 320388000702 putative active site [active] 320388000703 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388000704 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388000705 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388000706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388000707 Cupin domain; Region: Cupin_2; pfam07883 320388000708 short chain dehydrogenase; Provisional; Region: PRK12939 320388000709 classical (c) SDRs; Region: SDR_c; cd05233 320388000710 NAD(P) binding site [chemical binding]; other site 320388000711 active site 320388000712 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320388000713 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320388000714 [2Fe-2S] cluster binding site [ion binding]; other site 320388000715 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320388000716 hydrophobic ligand binding site; other site 320388000717 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 320388000718 [2Fe-2S] cluster binding site [ion binding]; other site 320388000719 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388000720 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388000721 trimer interface [polypeptide binding]; other site 320388000722 eyelet of channel; other site 320388000723 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388000724 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388000725 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388000726 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 320388000727 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 320388000728 putative FMN binding site [chemical binding]; other site 320388000729 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 320388000730 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388000731 putative active site [active] 320388000732 putative metal binding site [ion binding]; other site 320388000733 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 320388000734 MgtC family; Region: MgtC; pfam02308 320388000735 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 320388000736 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320388000737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388000738 DNA binding residues [nucleotide binding] 320388000739 dimerization interface [polypeptide binding]; other site 320388000740 Autoinducer synthetase; Region: Autoind_synth; cl17404 320388000741 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 320388000742 NADH/NADPH cofactor binding site [chemical binding]; other site 320388000743 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 320388000744 dimerization interface [polypeptide binding]; other site 320388000745 active site 320388000746 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 320388000747 FOG: CBS domain [General function prediction only]; Region: COG0517 320388000748 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320388000749 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 320388000750 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320388000751 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388000752 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388000753 trimer interface [polypeptide binding]; other site 320388000754 eyelet of channel; other site 320388000755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388000756 putative DNA binding site [nucleotide binding]; other site 320388000757 dimerization interface [polypeptide binding]; other site 320388000758 putative Zn2+ binding site [ion binding]; other site 320388000759 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320388000760 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 320388000761 FMN binding site [chemical binding]; other site 320388000762 active site 320388000763 substrate binding site [chemical binding]; other site 320388000764 catalytic residue [active] 320388000765 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320388000766 Coenzyme A binding pocket [chemical binding]; other site 320388000767 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388000768 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388000769 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388000770 eyelet of channel; other site 320388000771 trimer interface [polypeptide binding]; other site 320388000772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388000773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388000774 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 320388000775 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 320388000776 hypothetical protein; Provisional; Region: PRK07481 320388000777 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388000778 inhibitor-cofactor binding pocket; inhibition site 320388000779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388000780 catalytic residue [active] 320388000781 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388000782 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388000783 NAD(P) binding site [chemical binding]; other site 320388000784 catalytic residues [active] 320388000785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388000786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388000787 DNA binding residues [nucleotide binding] 320388000788 dimerization interface [polypeptide binding]; other site 320388000789 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 320388000790 classical (c) SDRs; Region: SDR_c; cd05233 320388000791 NAD(P) binding site [chemical binding]; other site 320388000792 active site 320388000793 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 320388000794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320388000795 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320388000796 active site 320388000797 catalytic tetrad [active] 320388000798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388000799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388000800 dimerization interface [polypeptide binding]; other site 320388000801 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 320388000802 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 320388000803 catalytic residues [active] 320388000804 transcriptional regulator; Provisional; Region: PRK10632 320388000805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000806 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388000807 putative effector binding pocket; other site 320388000808 dimerization interface [polypeptide binding]; other site 320388000809 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 320388000810 flagellar capping protein; Reviewed; Region: fliD; PRK08032 320388000811 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 320388000812 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 320388000813 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 320388000814 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 320388000815 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 320388000816 Transposase; Region: HTH_Tnp_1; pfam01527 320388000817 HTH-like domain; Region: HTH_21; pfam13276 320388000818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000819 Integrase core domain; Region: rve; pfam00665 320388000820 Integrase core domain; Region: rve_3; pfam13683 320388000821 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 320388000822 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320388000823 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320388000824 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 320388000825 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 320388000826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388000827 ATP binding site [chemical binding]; other site 320388000828 putative Mg++ binding site [ion binding]; other site 320388000829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388000830 nucleotide binding region [chemical binding]; other site 320388000831 ATP-binding site [chemical binding]; other site 320388000832 DEAD/H associated; Region: DEAD_assoc; pfam08494 320388000833 HTH-like domain; Region: HTH_21; pfam13276 320388000834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388000835 Integrase core domain; Region: rve; pfam00665 320388000836 Integrase core domain; Region: rve_3; pfam13683 320388000837 Transposase; Region: HTH_Tnp_1; pfam01527 320388000838 putative transporter; Provisional; Region: PRK11021 320388000839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 320388000840 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 320388000841 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320388000842 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 320388000843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388000844 S-adenosylmethionine binding site [chemical binding]; other site 320388000845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388000846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388000847 metal binding site [ion binding]; metal-binding site 320388000848 active site 320388000849 I-site; other site 320388000850 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 320388000851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388000852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388000853 dimerization interface [polypeptide binding]; other site 320388000854 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 320388000855 heterodimer interface [polypeptide binding]; other site 320388000856 multimer interface [polypeptide binding]; other site 320388000857 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 320388000858 active site 320388000859 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 320388000860 active site 320388000861 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 320388000862 SxDxEG motif; other site 320388000863 active site 320388000864 metal binding site [ion binding]; metal-binding site 320388000865 homopentamer interface [polypeptide binding]; other site 320388000866 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 320388000867 homotetramer interface [polypeptide binding]; other site 320388000868 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 320388000869 cleavage site 320388000870 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 320388000871 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 320388000872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000873 dimer interface [polypeptide binding]; other site 320388000874 conserved gate region; other site 320388000875 putative PBP binding loops; other site 320388000876 ABC-ATPase subunit interface; other site 320388000877 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 320388000878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388000879 dimer interface [polypeptide binding]; other site 320388000880 conserved gate region; other site 320388000881 putative PBP binding loops; other site 320388000882 ABC-ATPase subunit interface; other site 320388000883 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 320388000884 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 320388000885 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 320388000886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388000887 Walker A/P-loop; other site 320388000888 ATP binding site [chemical binding]; other site 320388000889 Q-loop/lid; other site 320388000890 ABC transporter signature motif; other site 320388000891 Walker B; other site 320388000892 D-loop; other site 320388000893 H-loop/switch region; other site 320388000894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 320388000895 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 320388000896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388000897 Walker A/P-loop; other site 320388000898 ATP binding site [chemical binding]; other site 320388000899 Q-loop/lid; other site 320388000900 ABC transporter signature motif; other site 320388000901 Walker B; other site 320388000902 D-loop; other site 320388000903 H-loop/switch region; other site 320388000904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388000905 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 320388000906 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 320388000907 catalytic nucleophile [active] 320388000908 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388000909 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388000910 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320388000911 putative active site [active] 320388000912 BCCT family transporter; Region: BCCT; pfam02028 320388000913 Beta-lactamase; Region: Beta-lactamase; pfam00144 320388000914 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 320388000915 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320388000916 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 320388000917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388000918 active site 320388000919 HIGH motif; other site 320388000920 nucleotide binding site [chemical binding]; other site 320388000921 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388000922 active site 320388000923 KMSKS motif; other site 320388000924 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 320388000925 tRNA binding surface [nucleotide binding]; other site 320388000926 anticodon binding site; other site 320388000927 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320388000928 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388000929 EamA-like transporter family; Region: EamA; pfam00892 320388000930 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 320388000931 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320388000932 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388000933 FAD binding domain; Region: FAD_binding_4; pfam01565 320388000934 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 320388000935 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388000936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388000937 S-adenosylmethionine binding site [chemical binding]; other site 320388000938 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388000939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388000940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388000941 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 320388000942 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 320388000943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388000944 catalytic residue [active] 320388000945 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 320388000946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388000947 putative DNA binding site [nucleotide binding]; other site 320388000948 putative Zn2+ binding site [ion binding]; other site 320388000949 AsnC family; Region: AsnC_trans_reg; pfam01037 320388000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000951 putative substrate translocation pore; other site 320388000952 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320388000953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388000954 DNA-binding site [nucleotide binding]; DNA binding site 320388000955 UTRA domain; Region: UTRA; pfam07702 320388000956 benzoate transport; Region: 2A0115; TIGR00895 320388000957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388000958 putative substrate translocation pore; other site 320388000959 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320388000960 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388000961 active site 320388000962 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388000963 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320388000964 active site 320388000965 metal binding site [ion binding]; metal-binding site 320388000966 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 320388000967 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 320388000968 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 320388000969 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 320388000970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 320388000971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388000972 Coenzyme A binding pocket [chemical binding]; other site 320388000973 Predicted transporter component [General function prediction only]; Region: COG2391 320388000974 Sulphur transport; Region: Sulf_transp; pfam04143 320388000975 Predicted transporter component [General function prediction only]; Region: COG2391 320388000976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388000977 dimerization interface [polypeptide binding]; other site 320388000978 putative DNA binding site [nucleotide binding]; other site 320388000979 putative Zn2+ binding site [ion binding]; other site 320388000980 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320388000981 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 320388000982 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 320388000983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388000984 catalytic residue [active] 320388000985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388000986 non-specific DNA binding site [nucleotide binding]; other site 320388000987 salt bridge; other site 320388000988 sequence-specific DNA binding site [nucleotide binding]; other site 320388000989 serine O-acetyltransferase; Region: cysE; TIGR01172 320388000990 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320388000991 trimer interface [polypeptide binding]; other site 320388000992 active site 320388000993 substrate binding site [chemical binding]; other site 320388000994 CoA binding site [chemical binding]; other site 320388000995 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 320388000996 active site residue [active] 320388000997 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 320388000998 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320388000999 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 320388001000 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388001001 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388001002 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388001003 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 320388001004 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 320388001005 Ligand binding site; other site 320388001006 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388001007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001008 putative substrate translocation pore; other site 320388001009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001010 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 320388001011 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 320388001012 active site 320388001013 TDP-binding site; other site 320388001014 acceptor substrate-binding pocket; other site 320388001015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388001016 HTH-like domain; Region: HTH_21; pfam13276 320388001017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001018 Integrase core domain; Region: rve; pfam00665 320388001019 Integrase core domain; Region: rve_3; pfam13683 320388001020 Transposase; Region: HTH_Tnp_1; pfam01527 320388001021 transcriptional regulator BetI; Validated; Region: PRK00767 320388001022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388001023 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 320388001024 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 320388001025 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388001026 NAD(P) binding site [chemical binding]; other site 320388001027 catalytic residues [active] 320388001028 choline dehydrogenase; Validated; Region: PRK02106 320388001029 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388001030 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 320388001031 benzoate transport; Region: 2A0115; TIGR00895 320388001032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001033 putative substrate translocation pore; other site 320388001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001035 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320388001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388001037 active site 320388001038 phosphorylation site [posttranslational modification] 320388001039 intermolecular recognition site; other site 320388001040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388001041 PAS fold; Region: PAS_3; pfam08447 320388001042 putative active site [active] 320388001043 heme pocket [chemical binding]; other site 320388001044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 320388001045 Histidine kinase; Region: HisKA_3; pfam07730 320388001046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388001047 ATP binding site [chemical binding]; other site 320388001048 Mg2+ binding site [ion binding]; other site 320388001049 G-X-G motif; other site 320388001050 Response regulator receiver domain; Region: Response_reg; pfam00072 320388001051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388001052 active site 320388001053 phosphorylation site [posttranslational modification] 320388001054 intermolecular recognition site; other site 320388001055 dimerization interface [polypeptide binding]; other site 320388001056 CHASE3 domain; Region: CHASE3; pfam05227 320388001057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388001058 PAS domain; Region: PAS_9; pfam13426 320388001059 putative active site [active] 320388001060 heme pocket [chemical binding]; other site 320388001061 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320388001062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388001063 putative active site [active] 320388001064 heme pocket [chemical binding]; other site 320388001065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388001066 dimer interface [polypeptide binding]; other site 320388001067 phosphorylation site [posttranslational modification] 320388001068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388001069 ATP binding site [chemical binding]; other site 320388001070 Mg2+ binding site [ion binding]; other site 320388001071 G-X-G motif; other site 320388001072 OsmC-like protein; Region: OsmC; cl00767 320388001073 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320388001074 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 320388001075 putative ligand binding site [chemical binding]; other site 320388001076 NAD binding site [chemical binding]; other site 320388001077 catalytic site [active] 320388001078 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 320388001079 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320388001080 DNA-binding site [nucleotide binding]; DNA binding site 320388001081 RNA-binding motif; other site 320388001082 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 320388001083 active site 320388001084 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 320388001085 Transposase; Region: HTH_Tnp_1; pfam01527 320388001086 HTH-like domain; Region: HTH_21; pfam13276 320388001087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001088 Integrase core domain; Region: rve; pfam00665 320388001089 Integrase core domain; Region: rve_3; pfam13683 320388001090 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 320388001091 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 320388001092 tetrameric interface [polypeptide binding]; other site 320388001093 NAD binding site [chemical binding]; other site 320388001094 catalytic residues [active] 320388001095 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 320388001096 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388001097 inhibitor-cofactor binding pocket; inhibition site 320388001098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388001099 catalytic residue [active] 320388001100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388001101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388001103 dimerization interface [polypeptide binding]; other site 320388001104 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 320388001105 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388001106 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388001107 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 320388001108 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320388001109 DXD motif; other site 320388001110 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320388001111 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 320388001112 Cache domain; Region: Cache_1; pfam02743 320388001113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388001114 acyl-CoA synthetase; Validated; Region: PRK08162 320388001115 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 320388001116 acyl-activating enzyme (AAE) consensus motif; other site 320388001117 putative active site [active] 320388001118 AMP binding site [chemical binding]; other site 320388001119 putative CoA binding site [chemical binding]; other site 320388001120 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320388001121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320388001122 ligand binding site [chemical binding]; other site 320388001123 flexible hinge region; other site 320388001124 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320388001125 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 320388001126 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 320388001127 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388001128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388001129 DNA-binding site [nucleotide binding]; DNA binding site 320388001130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388001131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388001132 homodimer interface [polypeptide binding]; other site 320388001133 catalytic residue [active] 320388001134 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320388001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388001136 NAD(P) binding site [chemical binding]; other site 320388001137 active site 320388001138 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 320388001139 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320388001140 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 320388001141 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 320388001142 NAD binding site [chemical binding]; other site 320388001143 homotetramer interface [polypeptide binding]; other site 320388001144 homodimer interface [polypeptide binding]; other site 320388001145 substrate binding site [chemical binding]; other site 320388001146 active site 320388001147 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320388001148 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 320388001149 active site 320388001150 FMN binding site [chemical binding]; other site 320388001151 substrate binding site [chemical binding]; other site 320388001152 homotetramer interface [polypeptide binding]; other site 320388001153 catalytic residue [active] 320388001154 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320388001155 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 320388001156 potential catalytic triad [active] 320388001157 conserved cys residue [active] 320388001158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388001159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388001160 MASE1; Region: MASE1; pfam05231 320388001161 PAS fold; Region: PAS_3; pfam08447 320388001162 Transposase; Region: HTH_Tnp_1; pfam01527 320388001163 HTH-like domain; Region: HTH_21; pfam13276 320388001164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001165 Integrase core domain; Region: rve; pfam00665 320388001166 Integrase core domain; Region: rve_3; pfam13683 320388001167 Haemagglutinin; Region: HIM; pfam05662 320388001168 YadA-like C-terminal region; Region: YadA; pfam03895 320388001169 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320388001170 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320388001171 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 320388001172 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320388001173 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 320388001174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320388001175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388001176 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320388001177 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320388001178 carboxyltransferase (CT) interaction site; other site 320388001179 biotinylation site [posttranslational modification]; other site 320388001180 enoyl-CoA hydratase; Provisional; Region: PRK05995 320388001181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388001182 substrate binding site [chemical binding]; other site 320388001183 oxyanion hole (OAH) forming residues; other site 320388001184 trimer interface [polypeptide binding]; other site 320388001185 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 320388001186 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 320388001187 isovaleryl-CoA dehydrogenase; Region: PLN02519 320388001188 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 320388001189 substrate binding site [chemical binding]; other site 320388001190 FAD binding site [chemical binding]; other site 320388001191 catalytic base [active] 320388001192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388001193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388001194 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 320388001195 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 320388001196 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 320388001197 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320388001198 Multicopper oxidase; Region: Cu-oxidase; pfam00394 320388001199 Cytochrome c; Region: Cytochrom_C; pfam00034 320388001200 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320388001201 [2Fe-2S] cluster binding site [ion binding]; other site 320388001202 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320388001203 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320388001204 alpha subunit interface [polypeptide binding]; other site 320388001205 active site 320388001206 substrate binding site [chemical binding]; other site 320388001207 Fe binding site [ion binding]; other site 320388001208 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 320388001209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 320388001210 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388001211 catalytic residue [active] 320388001212 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 320388001213 Cupin-like domain; Region: Cupin_8; pfam13621 320388001214 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 320388001215 benzoate transport; Region: 2A0115; TIGR00895 320388001216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320388001219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388001220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388001221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388001222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 320388001223 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 320388001224 dimer interface [polypeptide binding]; other site 320388001225 phosphorylation site [posttranslational modification] 320388001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388001227 ATP binding site [chemical binding]; other site 320388001228 Mg2+ binding site [ion binding]; other site 320388001229 G-X-G motif; other site 320388001230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388001232 active site 320388001233 phosphorylation site [posttranslational modification] 320388001234 intermolecular recognition site; other site 320388001235 dimerization interface [polypeptide binding]; other site 320388001236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388001237 DNA binding site [nucleotide binding] 320388001238 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 320388001239 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 320388001240 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 320388001241 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 320388001242 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 320388001243 FAD binding pocket [chemical binding]; other site 320388001244 FAD binding motif [chemical binding]; other site 320388001245 catalytic residues [active] 320388001246 NAD binding pocket [chemical binding]; other site 320388001247 phosphate binding motif [ion binding]; other site 320388001248 beta-alpha-beta structure motif; other site 320388001249 ApbE family; Region: ApbE; pfam02424 320388001250 ApbE family; Region: ApbE; pfam02424 320388001251 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 320388001252 aldehyde dehydrogenase family 7 member; Region: PLN02315 320388001253 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 320388001254 tetrameric interface [polypeptide binding]; other site 320388001255 NAD binding site [chemical binding]; other site 320388001256 catalytic residues [active] 320388001257 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388001258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388001259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388001260 homodimer interface [polypeptide binding]; other site 320388001261 catalytic residue [active] 320388001262 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 320388001263 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388001264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388001266 dimerization interface [polypeptide binding]; other site 320388001267 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 320388001268 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 320388001269 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 320388001270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388001271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388001272 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320388001273 putative active site [active] 320388001274 catalytic site [active] 320388001275 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 320388001276 putative active site [active] 320388001277 catalytic site [active] 320388001278 PLD-like domain; Region: PLDc_2; pfam13091 320388001279 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320388001280 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 320388001281 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320388001282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001283 D-galactonate transporter; Region: 2A0114; TIGR00893 320388001284 putative substrate translocation pore; other site 320388001285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001286 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 320388001287 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 320388001288 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 320388001289 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320388001290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388001291 DNA-binding site [nucleotide binding]; DNA binding site 320388001292 FCD domain; Region: FCD; pfam07729 320388001293 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 320388001294 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 320388001295 metal binding site [ion binding]; metal-binding site 320388001296 substrate binding pocket [chemical binding]; other site 320388001297 putative oxidoreductase; Provisional; Region: PRK10083 320388001298 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 320388001299 putative NAD(P) binding site [chemical binding]; other site 320388001300 catalytic Zn binding site [ion binding]; other site 320388001301 structural Zn binding site [ion binding]; other site 320388001302 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 320388001303 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 320388001304 homodimer interface [polypeptide binding]; other site 320388001305 NAD binding pocket [chemical binding]; other site 320388001306 ATP binding pocket [chemical binding]; other site 320388001307 Mg binding site [ion binding]; other site 320388001308 active-site loop [active] 320388001309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388001310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388001311 hypothetical protein; Provisional; Region: PRK02399 320388001312 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 320388001313 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 320388001314 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 320388001315 putative hydrophobic ligand binding site [chemical binding]; other site 320388001316 protein interface [polypeptide binding]; other site 320388001317 gate; other site 320388001318 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 320388001319 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320388001320 Multicopper oxidase; Region: Cu-oxidase; pfam00394 320388001321 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388001322 Cytochrome c; Region: Cytochrom_C; pfam00034 320388001323 Uncharacterized conserved protein [Function unknown]; Region: COG1262 320388001324 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 320388001325 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320388001326 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320388001327 Cu(I) binding site [ion binding]; other site 320388001328 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320388001329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320388001330 amidase catalytic site [active] 320388001331 Zn binding residues [ion binding]; other site 320388001332 substrate binding site [chemical binding]; other site 320388001333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320388001334 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 320388001335 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388001336 trimer interface [polypeptide binding]; other site 320388001337 Haemagglutinin; Region: HIM; pfam05662 320388001338 YadA-like C-terminal region; Region: YadA; pfam03895 320388001339 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320388001340 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 320388001341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388001342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388001343 active site 320388001344 phosphorylation site [posttranslational modification] 320388001345 intermolecular recognition site; other site 320388001346 dimerization interface [polypeptide binding]; other site 320388001347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388001348 DNA binding site [nucleotide binding] 320388001349 MASE1; Region: MASE1; cl17823 320388001350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388001351 dimer interface [polypeptide binding]; other site 320388001352 phosphorylation site [posttranslational modification] 320388001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388001354 ATP binding site [chemical binding]; other site 320388001355 G-X-G motif; other site 320388001356 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320388001357 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320388001358 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320388001359 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 320388001360 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 320388001361 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320388001362 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388001363 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320388001364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388001365 Walker A motif; other site 320388001366 ATP binding site [chemical binding]; other site 320388001367 Walker B motif; other site 320388001368 arginine finger; other site 320388001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388001370 Walker A motif; other site 320388001371 ATP binding site [chemical binding]; other site 320388001372 Walker B motif; other site 320388001373 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320388001374 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 320388001375 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388001376 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388001377 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 320388001378 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388001380 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320388001381 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388001382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388001383 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001384 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001385 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001386 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388001387 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320388001388 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320388001389 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320388001390 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320388001391 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320388001392 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320388001393 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 320388001394 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320388001395 Bacterial Ig-like domain; Region: Big_5; pfam13205 320388001396 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 320388001397 active site 320388001398 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 320388001399 active site 320388001400 Transposase; Region: HTH_Tnp_1; pfam01527 320388001401 HTH-like domain; Region: HTH_21; pfam13276 320388001402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001403 Integrase core domain; Region: rve; pfam00665 320388001404 Integrase core domain; Region: rve_3; pfam13683 320388001405 enoyl-CoA hydratase; Provisional; Region: PRK05862 320388001406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388001407 substrate binding site [chemical binding]; other site 320388001408 oxyanion hole (OAH) forming residues; other site 320388001409 trimer interface [polypeptide binding]; other site 320388001410 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 320388001411 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388001412 NAD(P) binding site [chemical binding]; other site 320388001413 catalytic residues [active] 320388001414 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 320388001415 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388001416 dimer interface [polypeptide binding]; other site 320388001417 active site 320388001418 enoyl-CoA hydratase; Provisional; Region: PRK08140 320388001419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388001420 substrate binding site [chemical binding]; other site 320388001421 oxyanion hole (OAH) forming residues; other site 320388001422 trimer interface [polypeptide binding]; other site 320388001423 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320388001424 CoenzymeA binding site [chemical binding]; other site 320388001425 subunit interaction site [polypeptide binding]; other site 320388001426 PHB binding site; other site 320388001427 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 320388001428 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 320388001429 active site 320388001430 AMP binding site [chemical binding]; other site 320388001431 homodimer interface [polypeptide binding]; other site 320388001432 acyl-activating enzyme (AAE) consensus motif; other site 320388001433 CoA binding site [chemical binding]; other site 320388001434 MltA specific insert domain; Region: MltA; cl08398 320388001435 3D domain; Region: 3D; pfam06725 320388001436 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 320388001437 MltA specific insert domain; Region: MltA; cl08398 320388001438 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 320388001439 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 320388001440 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 320388001441 substrate binding site [chemical binding]; other site 320388001442 hexamer interface [polypeptide binding]; other site 320388001443 metal binding site [ion binding]; metal-binding site 320388001444 phosphoglycolate phosphatase; Provisional; Region: PRK13222 320388001445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388001446 motif II; other site 320388001447 anthranilate synthase component I; Provisional; Region: PRK13565 320388001448 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 320388001449 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 320388001450 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 320388001451 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 320388001452 glutamine binding [chemical binding]; other site 320388001453 catalytic triad [active] 320388001454 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 320388001455 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320388001456 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 320388001457 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 320388001458 active site 320388001459 ribulose/triose binding site [chemical binding]; other site 320388001460 phosphate binding site [ion binding]; other site 320388001461 substrate (anthranilate) binding pocket [chemical binding]; other site 320388001462 product (indole) binding pocket [chemical binding]; other site 320388001463 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 320388001464 putative active site [active] 320388001465 putative metal binding residues [ion binding]; other site 320388001466 signature motif; other site 320388001467 putative triphosphate binding site [ion binding]; other site 320388001468 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 320388001469 ligand binding site [chemical binding]; other site 320388001470 active site 320388001471 UGI interface [polypeptide binding]; other site 320388001472 catalytic site [active] 320388001473 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 320388001474 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388001475 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 320388001476 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 320388001477 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388001478 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 320388001479 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 320388001480 dimerization domain [polypeptide binding]; other site 320388001481 dimer interface [polypeptide binding]; other site 320388001482 catalytic residues [active] 320388001483 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 320388001484 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 320388001485 GTP-binding protein YchF; Reviewed; Region: PRK09601 320388001486 YchF GTPase; Region: YchF; cd01900 320388001487 G1 box; other site 320388001488 GTP/Mg2+ binding site [chemical binding]; other site 320388001489 Switch I region; other site 320388001490 G2 box; other site 320388001491 Switch II region; other site 320388001492 G3 box; other site 320388001493 G4 box; other site 320388001494 G5 box; other site 320388001495 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 320388001496 NADH dehydrogenase subunit B; Validated; Region: PRK06411 320388001497 Helix-turn-helix domain; Region: HTH_18; pfam12833 320388001498 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 320388001499 Protein of unknown function (DUF419); Region: DUF419; cl15265 320388001500 Protein of unknown function (DUF419); Region: DUF419; cl15265 320388001501 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 320388001502 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 320388001503 active site 320388001504 catalytic site [active] 320388001505 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 320388001506 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 320388001507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388001508 Walker A/P-loop; other site 320388001509 ATP binding site [chemical binding]; other site 320388001510 Q-loop/lid; other site 320388001511 ABC transporter signature motif; other site 320388001512 Walker B; other site 320388001513 D-loop; other site 320388001514 H-loop/switch region; other site 320388001515 ABC transporter; Region: ABC_tran_2; pfam12848 320388001516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388001517 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 320388001518 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 320388001519 Isochorismatase family; Region: Isochorismatase; pfam00857 320388001520 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 320388001521 catalytic triad [active] 320388001522 conserved cis-peptide bond; other site 320388001523 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 320388001524 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 320388001525 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 320388001526 active site 320388001527 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 320388001528 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 320388001529 tRNA; other site 320388001530 putative tRNA binding site [nucleotide binding]; other site 320388001531 putative NADP binding site [chemical binding]; other site 320388001532 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 320388001533 peptide chain release factor 1; Validated; Region: prfA; PRK00591 320388001534 This domain is found in peptide chain release factors; Region: PCRF; smart00937 320388001535 RF-1 domain; Region: RF-1; pfam00472 320388001536 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 320388001537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388001538 S-adenosylmethionine binding site [chemical binding]; other site 320388001539 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 320388001540 putative GSH binding site [chemical binding]; other site 320388001541 catalytic residues [active] 320388001542 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 320388001543 Flavoprotein; Region: Flavoprotein; pfam02441 320388001544 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 320388001545 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 320388001546 putative active site [active] 320388001547 metal binding site [ion binding]; metal-binding site 320388001548 amino acid transporter; Region: 2A0306; TIGR00909 320388001549 Transposase; Region: HTH_Tnp_1; pfam01527 320388001550 HTH-like domain; Region: HTH_21; pfam13276 320388001551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001552 Integrase core domain; Region: rve; pfam00665 320388001553 Integrase core domain; Region: rve_3; pfam13683 320388001554 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320388001555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320388001556 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320388001557 active site 320388001558 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 320388001559 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388001560 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388001561 Uncharacterized conserved protein [Function unknown]; Region: COG3246 320388001562 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320388001563 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 320388001564 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388001565 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320388001566 conserved cys residue [active] 320388001567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388001568 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 320388001569 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 320388001570 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320388001571 Zn binding site [ion binding]; other site 320388001572 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 320388001573 Peptidase family M28; Region: Peptidase_M28; pfam04389 320388001574 active site 320388001575 metal binding site [ion binding]; metal-binding site 320388001576 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388001577 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388001578 trimer interface [polypeptide binding]; other site 320388001579 eyelet of channel; other site 320388001580 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320388001581 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 320388001582 choline-sulfatase; Region: chol_sulfatase; TIGR03417 320388001583 Sulfatase; Region: Sulfatase; cl17466 320388001584 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 320388001585 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 320388001586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001587 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320388001588 substrate binding pocket [chemical binding]; other site 320388001589 dimerization interface [polypeptide binding]; other site 320388001590 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 320388001591 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 320388001592 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 320388001593 putative active site [active] 320388001594 putative substrate binding site [chemical binding]; other site 320388001595 putative cosubstrate binding site; other site 320388001596 catalytic site [active] 320388001597 Amino acid permease; Region: AA_permease_2; pfam13520 320388001598 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320388001599 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 320388001600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320388001601 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 320388001602 FAD binding pocket [chemical binding]; other site 320388001603 FAD binding motif [chemical binding]; other site 320388001604 phosphate binding motif [ion binding]; other site 320388001605 beta-alpha-beta structure motif; other site 320388001606 NAD binding pocket [chemical binding]; other site 320388001607 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 320388001608 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388001609 catalytic loop [active] 320388001610 iron binding site [ion binding]; other site 320388001611 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320388001612 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320388001613 [2Fe-2S] cluster binding site [ion binding]; other site 320388001614 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 320388001615 putative alpha subunit interface [polypeptide binding]; other site 320388001616 putative active site [active] 320388001617 putative substrate binding site [chemical binding]; other site 320388001618 Fe binding site [ion binding]; other site 320388001619 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 320388001620 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 320388001621 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 320388001622 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 320388001623 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320388001624 Cysteine-rich domain; Region: CCG; pfam02754 320388001625 Cysteine-rich domain; Region: CCG; pfam02754 320388001626 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 320388001627 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 320388001628 putative active site [active] 320388001629 putative FMN binding site [chemical binding]; other site 320388001630 putative substrate binding site [chemical binding]; other site 320388001631 putative catalytic residue [active] 320388001632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320388001633 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 320388001634 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 320388001635 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 320388001636 active site 320388001637 dimer interface [polypeptide binding]; other site 320388001638 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 320388001639 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 320388001640 dimer interface [polypeptide binding]; other site 320388001641 active site 320388001642 glycine-pyridoxal phosphate binding site [chemical binding]; other site 320388001643 folate binding site [chemical binding]; other site 320388001644 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388001645 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320388001646 conserved cys residue [active] 320388001647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388001648 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 320388001649 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 320388001650 NAD binding site [chemical binding]; other site 320388001651 catalytic Zn binding site [ion binding]; other site 320388001652 structural Zn binding site [ion binding]; other site 320388001653 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320388001654 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320388001655 DNA binding site [nucleotide binding] 320388001656 domain linker motif; other site 320388001657 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 320388001658 ligand binding site [chemical binding]; other site 320388001659 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 320388001660 active site 320388001661 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 320388001662 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 320388001663 substrate binding [chemical binding]; other site 320388001664 active site 320388001665 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 320388001666 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 320388001667 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388001668 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388001669 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388001670 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 320388001671 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 320388001672 Ligand binding site; other site 320388001673 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388001674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001675 putative substrate translocation pore; other site 320388001676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001677 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 320388001678 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 320388001679 active site 320388001680 TDP-binding site; other site 320388001681 acceptor substrate-binding pocket; other site 320388001682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388001683 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320388001684 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388001685 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320388001686 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320388001687 hypothetical protein; Provisional; Region: PRK14693 320388001688 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 320388001689 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388001690 ligand binding site [chemical binding]; other site 320388001691 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 320388001692 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320388001693 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 320388001694 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320388001695 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320388001696 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320388001697 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001698 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320388001699 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388001700 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 320388001701 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001702 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388001703 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320388001704 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388001705 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388001706 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320388001707 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388001708 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388001709 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320388001710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388001711 Walker A motif; other site 320388001712 ATP binding site [chemical binding]; other site 320388001713 Walker B motif; other site 320388001714 arginine finger; other site 320388001715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320388001716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388001717 Walker A motif; other site 320388001718 ATP binding site [chemical binding]; other site 320388001719 Walker B motif; other site 320388001720 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320388001721 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320388001722 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 320388001723 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388001724 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320388001725 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 320388001726 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320388001727 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320388001728 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320388001729 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320388001730 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320388001731 HTH-like domain; Region: HTH_21; pfam13276 320388001732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001733 Integrase core domain; Region: rve; pfam00665 320388001734 Integrase core domain; Region: rve_3; pfam13683 320388001735 Transposase; Region: HTH_Tnp_1; pfam01527 320388001736 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 320388001737 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 320388001738 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 320388001739 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 320388001740 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 320388001741 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 320388001742 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 320388001743 active site 320388001744 metal-binding site 320388001745 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 320388001746 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320388001747 tetramer interface [polypeptide binding]; other site 320388001748 active site 320388001749 Mg2+/Mn2+ binding site [ion binding]; other site 320388001750 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 320388001751 active site 320388001752 metal-binding site 320388001753 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 320388001754 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388001755 dimer interface [polypeptide binding]; other site 320388001756 PYR/PP interface [polypeptide binding]; other site 320388001757 TPP binding site [chemical binding]; other site 320388001758 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320388001759 TPP-binding site [chemical binding]; other site 320388001760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388001761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388001762 catalytic residue [active] 320388001763 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320388001764 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 320388001765 conserved cys residue [active] 320388001766 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388001767 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320388001768 conserved cys residue [active] 320388001769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388001770 Predicted membrane protein [Function unknown]; Region: COG1289 320388001771 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320388001772 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 320388001773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001774 putative substrate translocation pore; other site 320388001775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388001776 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388001777 DNA-binding site [nucleotide binding]; DNA binding site 320388001778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388001779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388001780 homodimer interface [polypeptide binding]; other site 320388001781 catalytic residue [active] 320388001782 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320388001783 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320388001784 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320388001785 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 320388001786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 320388001787 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 320388001788 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320388001789 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320388001790 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320388001791 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 320388001792 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 320388001793 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320388001794 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320388001795 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320388001796 Transglutaminase/protease-like homologues; Region: TGc; smart00460 320388001797 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 320388001798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 320388001799 Uncharacterized conserved protein [Function unknown]; Region: COG2308 320388001800 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 320388001801 putative FMN binding site [chemical binding]; other site 320388001802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 320388001803 Chitin binding domain; Region: Chitin_bind_3; pfam03067 320388001804 peroxiredoxin; Region: AhpC; TIGR03137 320388001805 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 320388001806 dimer interface [polypeptide binding]; other site 320388001807 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320388001808 catalytic triad [active] 320388001809 peroxidatic and resolving cysteines [active] 320388001810 Transposase; Region: HTH_Tnp_1; pfam01527 320388001811 HTH-like domain; Region: HTH_21; pfam13276 320388001812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388001813 Integrase core domain; Region: rve; pfam00665 320388001814 Integrase core domain; Region: rve_3; pfam13683 320388001815 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 320388001816 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 320388001817 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 320388001818 acetyl-CoA synthetase; Provisional; Region: PRK00174 320388001819 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 320388001820 active site 320388001821 CoA binding site [chemical binding]; other site 320388001822 acyl-activating enzyme (AAE) consensus motif; other site 320388001823 AMP binding site [chemical binding]; other site 320388001824 acetate binding site [chemical binding]; other site 320388001825 EamA-like transporter family; Region: EamA; pfam00892 320388001826 EamA-like transporter family; Region: EamA; pfam00892 320388001827 hypothetical protein; Provisional; Region: PRK05208 320388001828 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 320388001829 Fumarase C-terminus; Region: Fumerase_C; pfam05683 320388001830 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 320388001831 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 320388001832 heme binding site [chemical binding]; other site 320388001833 ferroxidase pore; other site 320388001834 ferroxidase diiron center [ion binding]; other site 320388001835 glutamate racemase; Provisional; Region: PRK00865 320388001836 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 320388001837 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 320388001838 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 320388001839 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320388001840 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 320388001841 Transposase domain (DUF772); Region: DUF772; pfam05598 320388001842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388001843 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388001844 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 320388001845 DAK2 domain; Region: Dak2; pfam02734 320388001846 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 320388001847 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 320388001848 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320388001849 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 320388001850 putative NAD(P) binding site [chemical binding]; other site 320388001851 catalytic Zn binding site [ion binding]; other site 320388001852 structural Zn binding site [ion binding]; other site 320388001853 short chain dehydrogenase; Provisional; Region: PRK06841 320388001854 classical (c) SDRs; Region: SDR_c; cd05233 320388001855 NAD(P) binding site [chemical binding]; other site 320388001856 active site 320388001857 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 320388001858 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320388001859 putative ligand binding site [chemical binding]; other site 320388001860 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388001861 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320388001862 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320388001863 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320388001864 Walker A/P-loop; other site 320388001865 ATP binding site [chemical binding]; other site 320388001866 Q-loop/lid; other site 320388001867 ABC transporter signature motif; other site 320388001868 Walker B; other site 320388001869 D-loop; other site 320388001870 H-loop/switch region; other site 320388001871 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320388001872 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 320388001873 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 320388001874 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320388001875 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 320388001876 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388001877 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388001878 trimer interface [polypeptide binding]; other site 320388001879 eyelet of channel; other site 320388001880 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 320388001881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388001882 dimer interface [polypeptide binding]; other site 320388001883 conserved gate region; other site 320388001884 putative PBP binding loops; other site 320388001885 ABC-ATPase subunit interface; other site 320388001886 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320388001887 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320388001888 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320388001889 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320388001890 Walker A/P-loop; other site 320388001891 ATP binding site [chemical binding]; other site 320388001892 Q-loop/lid; other site 320388001893 ABC transporter signature motif; other site 320388001894 Walker B; other site 320388001895 D-loop; other site 320388001896 H-loop/switch region; other site 320388001897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388001898 dimer interface [polypeptide binding]; other site 320388001899 conserved gate region; other site 320388001900 putative PBP binding loops; other site 320388001901 ABC-ATPase subunit interface; other site 320388001902 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388001903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388001905 dimerization interface [polypeptide binding]; other site 320388001906 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 320388001907 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388001908 N-terminal plug; other site 320388001909 ligand-binding site [chemical binding]; other site 320388001910 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 320388001911 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 320388001912 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 320388001913 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 320388001914 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 320388001915 intersubunit interface [polypeptide binding]; other site 320388001916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320388001917 putative PBP binding regions; other site 320388001918 ABC-ATPase subunit interface; other site 320388001919 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 320388001920 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320388001921 Walker A/P-loop; other site 320388001922 ATP binding site [chemical binding]; other site 320388001923 Q-loop/lid; other site 320388001924 ABC transporter signature motif; other site 320388001925 Walker B; other site 320388001926 D-loop; other site 320388001927 H-loop/switch region; other site 320388001928 Predicted membrane protein [Function unknown]; Region: COG2860 320388001929 UPF0126 domain; Region: UPF0126; pfam03458 320388001930 UPF0126 domain; Region: UPF0126; pfam03458 320388001931 Transglycosylase; Region: Transgly; pfam00912 320388001932 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 320388001933 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320388001934 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 320388001935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001936 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 320388001937 putative dimerization interface [polypeptide binding]; other site 320388001938 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 320388001939 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 320388001940 tetramer interface [polypeptide binding]; other site 320388001941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388001942 catalytic residue [active] 320388001943 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 320388001944 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 320388001945 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 320388001946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388001947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388001948 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320388001949 active site lid residues [active] 320388001950 substrate binding pocket [chemical binding]; other site 320388001951 catalytic residues [active] 320388001952 substrate-Mg2+ binding site; other site 320388001953 aspartate-rich region 1; other site 320388001954 aspartate-rich region 2; other site 320388001955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388001956 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 320388001957 active site 320388001958 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 320388001959 Sulfatase; Region: Sulfatase; cl17466 320388001960 Sulfatase; Region: Sulfatase; cl17466 320388001961 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320388001962 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320388001963 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320388001964 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320388001965 Uncharacterized conserved protein [Function unknown]; Region: COG5361 320388001966 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 320388001967 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 320388001968 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 320388001969 Heavy-metal-associated domain; Region: HMA; pfam00403 320388001970 metal-binding site [ion binding] 320388001971 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320388001972 metal-binding site [ion binding] 320388001973 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320388001974 metal-binding site [ion binding] 320388001975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 320388001976 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320388001977 metal-binding site [ion binding] 320388001978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320388001979 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 320388001980 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 320388001981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388001982 Coenzyme A binding pocket [chemical binding]; other site 320388001983 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 320388001984 MgtC family; Region: MgtC; pfam02308 320388001985 dimerization interface [polypeptide binding]; other site 320388001986 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 320388001987 putative active cleft [active] 320388001988 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 320388001989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388001990 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320388001991 dimerization interface [polypeptide binding]; other site 320388001992 substrate binding pocket [chemical binding]; other site 320388001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388001994 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 320388001995 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 320388001996 dimer interface [polypeptide binding]; other site 320388001997 ligand binding site [chemical binding]; other site 320388001998 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388001999 dimer interface [polypeptide binding]; other site 320388002000 putative CheW interface [polypeptide binding]; other site 320388002001 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 320388002002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388002003 FeS/SAM binding site; other site 320388002004 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 320388002005 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 320388002006 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320388002007 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 320388002008 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320388002009 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320388002010 MAEBL; Provisional; Region: PTZ00121 320388002011 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320388002012 CoenzymeA binding site [chemical binding]; other site 320388002013 subunit interaction site [polypeptide binding]; other site 320388002014 PHB binding site; other site 320388002015 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 320388002016 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 320388002017 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 320388002018 substrate binding site [chemical binding]; other site 320388002019 ligand binding site [chemical binding]; other site 320388002020 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 320388002021 substrate binding site [chemical binding]; other site 320388002022 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 320388002023 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 320388002024 dimer interface [polypeptide binding]; other site 320388002025 active site 320388002026 citrylCoA binding site [chemical binding]; other site 320388002027 oxalacetate/citrate binding site [chemical binding]; other site 320388002028 coenzyme A binding site [chemical binding]; other site 320388002029 catalytic triad [active] 320388002030 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 320388002031 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320388002032 tetramer interface [polypeptide binding]; other site 320388002033 active site 320388002034 Mg2+/Mn2+ binding site [ion binding]; other site 320388002035 Propionate catabolism activator; Region: PrpR_N; pfam06506 320388002036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388002037 putative active site [active] 320388002038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320388002040 Walker A motif; other site 320388002041 ATP binding site [chemical binding]; other site 320388002042 Walker B motif; other site 320388002043 arginine finger; other site 320388002044 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320388002045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388002046 dimerization interface [polypeptide binding]; other site 320388002047 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388002048 dimer interface [polypeptide binding]; other site 320388002049 putative CheW interface [polypeptide binding]; other site 320388002050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388002051 S-adenosylmethionine binding site [chemical binding]; other site 320388002052 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 320388002053 TAP-like protein; Region: Abhydrolase_4; pfam08386 320388002054 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320388002055 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320388002056 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320388002057 active site 320388002058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002060 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 320388002061 putative substrate binding pocket [chemical binding]; other site 320388002062 dimerization interface [polypeptide binding]; other site 320388002063 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 320388002064 putative active site [active] 320388002065 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320388002066 carboxyltransferase (CT) interaction site; other site 320388002067 biotinylation site [posttranslational modification]; other site 320388002068 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 320388002069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320388002070 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388002071 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320388002072 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 320388002073 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 320388002074 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 320388002075 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 320388002076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388002077 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 320388002078 dimer interface [polypeptide binding]; other site 320388002079 putative metal binding site [ion binding]; other site 320388002080 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 320388002081 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 320388002082 homodimer interface [polypeptide binding]; other site 320388002083 substrate-cofactor binding pocket; other site 320388002084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388002085 catalytic residue [active] 320388002086 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 320388002087 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388002088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 320388002091 putative substrate binding pocket [chemical binding]; other site 320388002092 putative dimerization interface [polypeptide binding]; other site 320388002093 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320388002094 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320388002095 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320388002096 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320388002097 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320388002098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002099 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002100 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 320388002101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002102 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320388002103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002104 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002105 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320388002106 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320388002107 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388002108 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388002109 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320388002110 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320388002111 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320388002112 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388002113 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320388002114 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 320388002115 ImpE protein; Region: ImpE; pfam07024 320388002116 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320388002117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002118 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320388002119 Walker A motif; other site 320388002120 ATP binding site [chemical binding]; other site 320388002121 Walker B motif; other site 320388002122 arginine finger; other site 320388002123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002124 Walker A motif; other site 320388002125 ATP binding site [chemical binding]; other site 320388002126 Walker B motif; other site 320388002127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320388002128 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320388002129 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 320388002130 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320388002131 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320388002132 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 320388002133 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320388002134 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320388002135 hypothetical protein; Provisional; Region: PRK08126 320388002136 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 320388002137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388002138 ligand binding site [chemical binding]; other site 320388002139 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 320388002140 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388002141 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388002142 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320388002143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002145 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388002146 putative effector binding pocket; other site 320388002147 dimerization interface [polypeptide binding]; other site 320388002148 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 320388002149 active site 320388002150 metal binding site [ion binding]; metal-binding site 320388002151 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320388002152 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320388002153 NADP binding site [chemical binding]; other site 320388002154 dimer interface [polypeptide binding]; other site 320388002155 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 320388002156 active site 320388002157 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 320388002158 dimer interface [polypeptide binding]; other site 320388002159 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320388002160 Ligand Binding Site [chemical binding]; other site 320388002161 Molecular Tunnel; other site 320388002162 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 320388002163 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 320388002164 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320388002165 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320388002166 substrate binding pocket [chemical binding]; other site 320388002167 active site 320388002168 iron coordination sites [ion binding]; other site 320388002169 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 320388002170 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 320388002171 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 320388002172 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 320388002173 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320388002174 SnoaL-like domain; Region: SnoaL_2; pfam12680 320388002175 short chain dehydrogenase; Provisional; Region: PRK07023 320388002176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388002177 NAD(P) binding site [chemical binding]; other site 320388002178 active site 320388002179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388002182 dimerization interface [polypeptide binding]; other site 320388002183 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320388002184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320388002185 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 320388002186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388002187 substrate binding pocket [chemical binding]; other site 320388002188 membrane-bound complex binding site; other site 320388002189 hinge residues; other site 320388002190 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 320388002191 putative di-iron ligands [ion binding]; other site 320388002192 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 320388002193 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 320388002194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388002196 dimerization interface [polypeptide binding]; other site 320388002197 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 320388002198 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 320388002199 metal binding site [ion binding]; metal-binding site 320388002200 putative dimer interface [polypeptide binding]; other site 320388002201 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388002202 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388002203 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388002204 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 320388002205 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320388002206 ATP binding site [chemical binding]; other site 320388002207 Mg++ binding site [ion binding]; other site 320388002208 motif III; other site 320388002209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388002210 nucleotide binding region [chemical binding]; other site 320388002211 ATP-binding site [chemical binding]; other site 320388002212 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 320388002213 putative RNA binding site [nucleotide binding]; other site 320388002214 Transposase; Region: HTH_Tnp_1; pfam01527 320388002215 HTH-like domain; Region: HTH_21; pfam13276 320388002216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388002217 Integrase core domain; Region: rve; pfam00665 320388002218 Integrase core domain; Region: rve_3; pfam13683 320388002219 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388002220 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388002221 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388002222 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320388002223 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388002224 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 320388002225 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388002226 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388002227 trimer interface [polypeptide binding]; other site 320388002228 eyelet of channel; other site 320388002229 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 320388002230 2-methylcitrate dehydratase; Region: prpD; TIGR02330 320388002231 OpgC protein; Region: OpgC_C; pfam10129 320388002232 Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Region: DBF4; COG5067 320388002233 Predicted permeases [General function prediction only]; Region: RarD; COG2962 320388002234 acylphosphatase; Provisional; Region: PRK14424 320388002235 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 320388002236 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 320388002237 putative NADP binding site [chemical binding]; other site 320388002238 putative substrate binding site [chemical binding]; other site 320388002239 active site 320388002240 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 320388002241 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 320388002242 active site 320388002243 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 320388002244 LytB protein; Region: LYTB; pfam02401 320388002245 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 320388002246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388002247 FeS/SAM binding site; other site 320388002248 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 320388002249 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 320388002250 aminotransferase; Validated; Region: PRK07046 320388002251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388002252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388002253 catalytic residue [active] 320388002254 Transposase domain (DUF772); Region: DUF772; pfam05598 320388002255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388002256 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388002257 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320388002258 short chain dehydrogenase; Provisional; Region: PRK06701 320388002259 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 320388002260 NAD binding site [chemical binding]; other site 320388002261 metal binding site [ion binding]; metal-binding site 320388002262 active site 320388002263 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 320388002264 short chain dehydrogenase; Provisional; Region: PRK07109 320388002265 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 320388002266 putative NAD(P) binding site [chemical binding]; other site 320388002267 active site 320388002268 BON domain; Region: BON; pfam04972 320388002269 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 320388002270 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 320388002271 putative ADP-binding pocket [chemical binding]; other site 320388002272 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 320388002273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388002274 NAD binding site [chemical binding]; other site 320388002275 putative substrate binding site 2 [chemical binding]; other site 320388002276 putative substrate binding site 1 [chemical binding]; other site 320388002277 active site 320388002278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388002279 PAS domain; Region: PAS_9; pfam13426 320388002280 putative active site [active] 320388002281 heme pocket [chemical binding]; other site 320388002282 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320388002283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388002284 putative active site [active] 320388002285 heme pocket [chemical binding]; other site 320388002286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388002287 dimer interface [polypeptide binding]; other site 320388002288 phosphorylation site [posttranslational modification] 320388002289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388002290 ATP binding site [chemical binding]; other site 320388002291 Mg2+ binding site [ion binding]; other site 320388002292 G-X-G motif; other site 320388002293 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320388002294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002295 active site 320388002296 phosphorylation site [posttranslational modification] 320388002297 intermolecular recognition site; other site 320388002298 dimerization interface [polypeptide binding]; other site 320388002299 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 320388002300 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320388002301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388002302 active site 320388002303 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388002304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002305 active site 320388002306 phosphorylation site [posttranslational modification] 320388002307 intermolecular recognition site; other site 320388002308 dimerization interface [polypeptide binding]; other site 320388002309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002310 Walker A motif; other site 320388002311 ATP binding site [chemical binding]; other site 320388002312 Walker B motif; other site 320388002313 arginine finger; other site 320388002314 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002316 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 320388002317 Walker A motif; other site 320388002318 ATP binding site [chemical binding]; other site 320388002319 Walker B motif; other site 320388002320 arginine finger; other site 320388002321 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320388002322 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388002323 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388002324 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388002325 putative active site [active] 320388002326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388002327 active site 320388002328 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 320388002329 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 320388002330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388002331 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388002332 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388002333 putative active site [active] 320388002334 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 320388002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388002336 active site 320388002337 motif I; other site 320388002338 motif II; other site 320388002339 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320388002340 classical (c) SDRs; Region: SDR_c; cd05233 320388002341 NAD(P) binding site [chemical binding]; other site 320388002342 active site 320388002343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320388002344 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 320388002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388002346 Walker A/P-loop; other site 320388002347 ATP binding site [chemical binding]; other site 320388002348 Q-loop/lid; other site 320388002349 ABC transporter signature motif; other site 320388002350 Walker B; other site 320388002351 D-loop; other site 320388002352 H-loop/switch region; other site 320388002353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 320388002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002355 Response regulator receiver domain; Region: Response_reg; pfam00072 320388002356 active site 320388002357 phosphorylation site [posttranslational modification] 320388002358 intermolecular recognition site; other site 320388002359 dimerization interface [polypeptide binding]; other site 320388002360 BON domain; Region: BON; pfam04972 320388002361 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 320388002362 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 320388002363 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 320388002364 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 320388002365 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 320388002366 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320388002367 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320388002368 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320388002369 active site 320388002370 non-prolyl cis peptide bond; other site 320388002371 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 320388002372 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 320388002373 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 320388002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388002375 putative substrate translocation pore; other site 320388002376 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 320388002377 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320388002378 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 320388002379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388002380 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320388002381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320388002382 E3 interaction surface; other site 320388002383 lipoyl attachment site [posttranslational modification]; other site 320388002384 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 320388002385 e3 binding domain; Region: E3_binding; pfam02817 320388002386 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320388002387 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 320388002388 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 320388002389 alpha subunit interface [polypeptide binding]; other site 320388002390 TPP binding site [chemical binding]; other site 320388002391 heterodimer interface [polypeptide binding]; other site 320388002392 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320388002393 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 320388002394 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 320388002395 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 320388002396 tetramer interface [polypeptide binding]; other site 320388002397 TPP-binding site [chemical binding]; other site 320388002398 heterodimer interface [polypeptide binding]; other site 320388002399 phosphorylation loop region [posttranslational modification] 320388002400 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 320388002401 putative hydrophobic ligand binding site [chemical binding]; other site 320388002402 protein interface [polypeptide binding]; other site 320388002403 gate; other site 320388002404 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 320388002405 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 320388002406 hydrophobic ligand binding site; other site 320388002407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002409 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320388002410 substrate binding pocket [chemical binding]; other site 320388002411 dimerization interface [polypeptide binding]; other site 320388002412 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 320388002413 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388002414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320388002415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388002416 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320388002417 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320388002418 nucleophile elbow; other site 320388002419 Patatin phospholipase; Region: DUF3734; pfam12536 320388002420 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 320388002421 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 320388002422 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 320388002423 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 320388002424 active site 320388002425 dimer interface [polypeptide binding]; other site 320388002426 effector binding site; other site 320388002427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 320388002428 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 320388002429 AAA domain; Region: AAA_33; pfam13671 320388002430 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 320388002431 FMN binding site [chemical binding]; other site 320388002432 dimer interface [polypeptide binding]; other site 320388002433 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320388002434 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 320388002435 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320388002436 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 320388002437 FOG: CBS domain [General function prediction only]; Region: COG0517 320388002438 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 320388002439 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 320388002440 putative FMN binding site [chemical binding]; other site 320388002441 NADPH bind site [chemical binding]; other site 320388002442 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320388002443 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 320388002444 putative dimer interface [polypeptide binding]; other site 320388002445 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388002446 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388002447 trimer interface [polypeptide binding]; other site 320388002448 eyelet of channel; other site 320388002449 putative acyl-CoA synthetase; Provisional; Region: PRK06018 320388002450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388002451 acyl-activating enzyme (AAE) consensus motif; other site 320388002452 AMP binding site [chemical binding]; other site 320388002453 active site 320388002454 CoA binding site [chemical binding]; other site 320388002455 AAA ATPase domain; Region: AAA_16; pfam13191 320388002456 AAA domain; Region: AAA_22; pfam13401 320388002457 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388002458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388002459 DNA binding residues [nucleotide binding] 320388002460 dimerization interface [polypeptide binding]; other site 320388002461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 320388002462 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 320388002463 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320388002464 NADP binding site [chemical binding]; other site 320388002465 dimer interface [polypeptide binding]; other site 320388002466 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320388002467 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320388002468 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 320388002469 benzoate transport; Region: 2A0115; TIGR00895 320388002470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388002471 putative substrate translocation pore; other site 320388002472 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 320388002473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388002474 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320388002475 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388002476 molybdopterin cofactor binding site; other site 320388002477 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320388002478 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388002479 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 320388002480 putative molybdopterin cofactor binding site; other site 320388002481 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 320388002482 4Fe-4S binding domain; Region: Fer4; pfam00037 320388002483 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 320388002484 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 320388002485 putative active site [active] 320388002486 putative metal binding site [ion binding]; other site 320388002487 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 320388002488 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 320388002489 Transglycosylase; Region: Transgly; pfam00912 320388002490 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 320388002491 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320388002492 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320388002493 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388002494 catalytic residues [active] 320388002495 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388002496 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388002497 trimer interface [polypeptide binding]; other site 320388002498 eyelet of channel; other site 320388002499 amidase; Provisional; Region: PRK08137 320388002500 Amidase; Region: Amidase; cl11426 320388002501 putative acetyltransferase YhhY; Provisional; Region: PRK10140 320388002502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388002503 Coenzyme A binding pocket [chemical binding]; other site 320388002504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388002505 putative acetyltransferase YhhY; Provisional; Region: PRK10140 320388002506 Coenzyme A binding pocket [chemical binding]; other site 320388002507 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 320388002508 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 320388002509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388002510 D-loop; other site 320388002511 H-loop/switch region; other site 320388002512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388002513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 320388002514 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 320388002515 Histidine kinase; Region: HisKA_3; pfam07730 320388002516 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 320388002517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388002518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002519 active site 320388002520 phosphorylation site [posttranslational modification] 320388002521 intermolecular recognition site; other site 320388002522 dimerization interface [polypeptide binding]; other site 320388002523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388002524 DNA binding residues [nucleotide binding] 320388002525 dimerization interface [polypeptide binding]; other site 320388002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388002527 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388002528 Transposase domain (DUF772); Region: DUF772; pfam05598 320388002529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388002530 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388002531 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 320388002532 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 320388002533 PAS domain; Region: PAS_9; pfam13426 320388002534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388002535 putative active site [active] 320388002536 heme pocket [chemical binding]; other site 320388002537 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388002538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388002539 metal binding site [ion binding]; metal-binding site 320388002540 active site 320388002541 I-site; other site 320388002542 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320388002543 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 320388002544 Lipase (class 2); Region: Lipase_2; pfam01674 320388002545 PGAP1-like protein; Region: PGAP1; pfam07819 320388002546 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 320388002547 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 320388002548 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 320388002549 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 320388002550 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 320388002551 FtsX-like permease family; Region: FtsX; pfam02687 320388002552 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320388002553 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320388002554 Walker A/P-loop; other site 320388002555 ATP binding site [chemical binding]; other site 320388002556 Q-loop/lid; other site 320388002557 ABC transporter signature motif; other site 320388002558 Walker B; other site 320388002559 D-loop; other site 320388002560 H-loop/switch region; other site 320388002561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388002562 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 320388002563 Cytochrome P450; Region: p450; cl12078 320388002564 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320388002565 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320388002566 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320388002567 putative NADP binding site [chemical binding]; other site 320388002568 active site 320388002569 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 320388002570 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 320388002571 putative NAD(P) binding site [chemical binding]; other site 320388002572 active site 320388002573 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320388002574 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320388002575 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388002576 active site 320388002577 active site 320388002578 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320388002579 active site 320388002580 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320388002581 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320388002582 putative NADP binding site [chemical binding]; other site 320388002583 active site 320388002584 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320388002585 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320388002586 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 320388002587 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 320388002588 VacJ like lipoprotein; Region: VacJ; cl01073 320388002589 hypothetical protein; Provisional; Region: PRK07483 320388002590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388002591 inhibitor-cofactor binding pocket; inhibition site 320388002592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388002593 catalytic residue [active] 320388002594 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 320388002595 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 320388002596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388002597 Walker A/P-loop; other site 320388002598 ATP binding site [chemical binding]; other site 320388002599 Q-loop/lid; other site 320388002600 ABC transporter signature motif; other site 320388002601 Walker B; other site 320388002602 D-loop; other site 320388002603 H-loop/switch region; other site 320388002604 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388002605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388002606 dimer interface [polypeptide binding]; other site 320388002607 conserved gate region; other site 320388002608 putative PBP binding loops; other site 320388002609 ABC-ATPase subunit interface; other site 320388002610 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388002611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388002612 substrate binding pocket [chemical binding]; other site 320388002613 membrane-bound complex binding site; other site 320388002614 hinge residues; other site 320388002615 hypothetical protein; Provisional; Region: PRK07077 320388002616 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 320388002617 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 320388002618 Active site cavity [active] 320388002619 catalytic acid [active] 320388002620 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320388002621 active site lid residues [active] 320388002622 substrate binding pocket [chemical binding]; other site 320388002623 catalytic residues [active] 320388002624 substrate-Mg2+ binding site; other site 320388002625 aspartate-rich region 1; other site 320388002626 aspartate-rich region 2; other site 320388002627 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 320388002628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388002629 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388002630 PAS fold; Region: PAS_4; pfam08448 320388002631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388002632 putative active site [active] 320388002633 heme pocket [chemical binding]; other site 320388002634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388002635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388002636 metal binding site [ion binding]; metal-binding site 320388002637 active site 320388002638 I-site; other site 320388002639 Response regulator receiver domain; Region: Response_reg; pfam00072 320388002640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002641 active site 320388002642 phosphorylation site [posttranslational modification] 320388002643 intermolecular recognition site; other site 320388002644 dimerization interface [polypeptide binding]; other site 320388002645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388002646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388002647 dimer interface [polypeptide binding]; other site 320388002648 phosphorylation site [posttranslational modification] 320388002649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388002650 ATP binding site [chemical binding]; other site 320388002651 Mg2+ binding site [ion binding]; other site 320388002652 G-X-G motif; other site 320388002653 Response regulator receiver domain; Region: Response_reg; pfam00072 320388002654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002655 active site 320388002656 phosphorylation site [posttranslational modification] 320388002657 intermolecular recognition site; other site 320388002658 dimerization interface [polypeptide binding]; other site 320388002659 Predicted flavoprotein [General function prediction only]; Region: COG0431 320388002660 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388002661 RNA polymerase sigma factor; Provisional; Region: PRK12545 320388002662 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 320388002663 DNA binding residues [nucleotide binding] 320388002664 Putative zinc-finger; Region: zf-HC2; pfam13490 320388002665 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 320388002666 ArsC family; Region: ArsC; pfam03960 320388002667 catalytic residues [active] 320388002668 ParA-like protein; Provisional; Region: PHA02518 320388002669 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320388002670 P-loop; other site 320388002671 Magnesium ion binding site [ion binding]; other site 320388002672 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 320388002673 ParB-like nuclease domain; Region: ParB; smart00470 320388002674 Initiator Replication protein; Region: Rep_3; pfam01051 320388002675 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 320388002676 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 320388002677 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 320388002678 active site 320388002679 Int/Topo IB signature motif; other site 320388002680 catalytic residues [active] 320388002681 DNA binding site [nucleotide binding] 320388002682 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 320388002683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320388002684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388002685 non-specific DNA binding site [nucleotide binding]; other site 320388002686 salt bridge; other site 320388002687 sequence-specific DNA binding site [nucleotide binding]; other site 320388002688 Cupin domain; Region: Cupin_2; pfam07883 320388002689 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320388002690 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 320388002691 substrate-cofactor binding pocket; other site 320388002692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388002693 catalytic residue [active] 320388002694 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 320388002695 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320388002696 NAD(P) binding site [chemical binding]; other site 320388002697 Uncharacterized conserved protein [Function unknown]; Region: COG2353 320388002698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388002699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 320388002701 SnoaL-like domain; Region: SnoaL_2; pfam12680 320388002702 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 320388002703 putative active site [active] 320388002704 Zn binding site [ion binding]; other site 320388002705 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 320388002706 tartrate dehydrogenase; Region: TTC; TIGR02089 320388002707 transcriptional activator TtdR; Provisional; Region: PRK09801 320388002708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002709 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 320388002710 putative effector binding pocket; other site 320388002711 putative dimerization interface [polypeptide binding]; other site 320388002712 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 320388002713 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320388002714 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 320388002715 putative C-terminal domain interface [polypeptide binding]; other site 320388002716 putative GSH binding site (G-site) [chemical binding]; other site 320388002717 putative dimer interface [polypeptide binding]; other site 320388002718 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 320388002719 putative N-terminal domain interface [polypeptide binding]; other site 320388002720 putative dimer interface [polypeptide binding]; other site 320388002721 putative substrate binding pocket (H-site) [chemical binding]; other site 320388002722 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320388002723 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320388002724 nucleophile elbow; other site 320388002725 Patatin phospholipase; Region: DUF3734; pfam12536 320388002726 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 320388002727 classical (c) SDRs; Region: SDR_c; cd05233 320388002728 NAD(P) binding site [chemical binding]; other site 320388002729 active site 320388002730 acetoacetate decarboxylase; Provisional; Region: PRK02265 320388002731 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 320388002732 active site 320388002733 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 320388002734 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 320388002735 FAD binding pocket [chemical binding]; other site 320388002736 FAD binding motif [chemical binding]; other site 320388002737 phosphate binding motif [ion binding]; other site 320388002738 NAD binding pocket [chemical binding]; other site 320388002739 Predicted transcriptional regulators [Transcription]; Region: COG1695 320388002740 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 320388002741 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320388002742 Cytochrome P450; Region: p450; cl12078 320388002743 Protein of unknown function (DUF692); Region: DUF692; cl01263 320388002744 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 320388002745 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 320388002746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388002747 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 320388002748 FeS/SAM binding site; other site 320388002749 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388002750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388002751 S-adenosylmethionine binding site [chemical binding]; other site 320388002752 Lysine efflux permease [General function prediction only]; Region: COG1279 320388002753 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 320388002754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388002756 dimerization interface [polypeptide binding]; other site 320388002757 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 320388002758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320388002759 ligand binding site [chemical binding]; other site 320388002760 flexible hinge region; other site 320388002761 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320388002762 putative switch regulator; other site 320388002763 non-specific DNA interactions [nucleotide binding]; other site 320388002764 DNA binding site [nucleotide binding] 320388002765 sequence specific DNA binding site [nucleotide binding]; other site 320388002766 putative cAMP binding site [chemical binding]; other site 320388002767 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320388002768 Ligand Binding Site [chemical binding]; other site 320388002769 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 320388002770 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 320388002771 dimer interface [polypeptide binding]; other site 320388002772 NADP binding site [chemical binding]; other site 320388002773 catalytic residues [active] 320388002774 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 320388002775 Strictosidine synthase; Region: Str_synth; pfam03088 320388002776 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 320388002777 Transcriptional activator HlyU; Region: HlyU; cl02273 320388002778 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 320388002779 serine O-acetyltransferase; Region: cysE; TIGR01172 320388002780 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320388002781 trimer interface [polypeptide binding]; other site 320388002782 active site 320388002783 substrate binding site [chemical binding]; other site 320388002784 CoA binding site [chemical binding]; other site 320388002785 short chain dehydrogenase; Provisional; Region: PRK09134 320388002786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388002787 NAD(P) binding site [chemical binding]; other site 320388002788 active site 320388002789 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 320388002790 GTP cyclohydrolase I; Provisional; Region: PLN03044 320388002791 active site 320388002792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002794 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 320388002795 substrate binding pocket [chemical binding]; other site 320388002796 dimerization interface [polypeptide binding]; other site 320388002797 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 320388002798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320388002799 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 320388002800 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 320388002801 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 320388002802 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 320388002803 tetramer interface [polypeptide binding]; other site 320388002804 active site 320388002805 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 320388002806 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 320388002807 benzoate transport; Region: 2A0115; TIGR00895 320388002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388002809 putative substrate translocation pore; other site 320388002810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388002811 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388002812 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 320388002813 Chromate transporter; Region: Chromate_transp; pfam02417 320388002814 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 320388002815 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 320388002816 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 320388002817 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320388002818 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 320388002819 RNA polymerase sigma factor; Provisional; Region: PRK11922 320388002820 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388002821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388002822 DNA binding residues [nucleotide binding] 320388002823 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 320388002824 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320388002825 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320388002826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388002827 Walker A/P-loop; other site 320388002828 ATP binding site [chemical binding]; other site 320388002829 Q-loop/lid; other site 320388002830 ABC transporter signature motif; other site 320388002831 Walker B; other site 320388002832 D-loop; other site 320388002833 H-loop/switch region; other site 320388002834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388002835 Walker A/P-loop; other site 320388002836 ATP binding site [chemical binding]; other site 320388002837 Q-loop/lid; other site 320388002838 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320388002839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388002840 Walker A/P-loop; other site 320388002841 ATP binding site [chemical binding]; other site 320388002842 Q-loop/lid; other site 320388002843 ABC transporter signature motif; other site 320388002844 Walker B; other site 320388002845 D-loop; other site 320388002846 H-loop/switch region; other site 320388002847 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 320388002848 H-NS histone family; Region: Histone_HNS; pfam00816 320388002849 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388002850 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 320388002851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388002852 putative substrate translocation pore; other site 320388002853 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 320388002854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388002855 dimer interface [polypeptide binding]; other site 320388002856 phosphorylation site [posttranslational modification] 320388002857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388002858 ATP binding site [chemical binding]; other site 320388002859 Mg2+ binding site [ion binding]; other site 320388002860 G-X-G motif; other site 320388002861 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388002862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388002863 active site 320388002864 phosphorylation site [posttranslational modification] 320388002865 intermolecular recognition site; other site 320388002866 dimerization interface [polypeptide binding]; other site 320388002867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388002868 Walker A motif; other site 320388002869 ATP binding site [chemical binding]; other site 320388002870 Walker B motif; other site 320388002871 arginine finger; other site 320388002872 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388002873 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320388002874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388002875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388002876 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 320388002877 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320388002878 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320388002879 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320388002880 Transposase; Region: HTH_Tnp_1; pfam01527 320388002881 HTH-like domain; Region: HTH_21; pfam13276 320388002882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388002883 Integrase core domain; Region: rve; pfam00665 320388002884 Integrase core domain; Region: rve_3; pfam13683 320388002885 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 320388002886 Chain length determinant protein; Region: Wzz; pfam02706 320388002887 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 320388002888 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 320388002889 Phospholipid methyltransferase; Region: PEMT; cl17370 320388002890 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320388002891 peptidase domain interface [polypeptide binding]; other site 320388002892 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320388002893 active site 320388002894 catalytic triad [active] 320388002895 calcium binding site [ion binding]; other site 320388002896 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 320388002897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388002898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388002899 metal binding site [ion binding]; metal-binding site 320388002900 active site 320388002901 I-site; other site 320388002902 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388002903 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 320388002904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 320388002905 short chain dehydrogenase; Provisional; Region: PRK06181 320388002906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388002907 NAD(P) binding site [chemical binding]; other site 320388002908 active site 320388002909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388002910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388002911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388002912 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388002913 putative effector binding pocket; other site 320388002914 dimerization interface [polypeptide binding]; other site 320388002915 HTH-like domain; Region: HTH_21; pfam13276 320388002916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388002917 Integrase core domain; Region: rve; pfam00665 320388002918 Integrase core domain; Region: rve_3; pfam13683 320388002919 Transposase; Region: HTH_Tnp_1; pfam01527 320388002920 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 320388002921 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320388002922 putative C-terminal domain interface [polypeptide binding]; other site 320388002923 putative GSH binding site (G-site) [chemical binding]; other site 320388002924 putative dimer interface [polypeptide binding]; other site 320388002925 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 320388002926 N-terminal domain interface [polypeptide binding]; other site 320388002927 dimer interface [polypeptide binding]; other site 320388002928 substrate binding pocket (H-site) [chemical binding]; other site 320388002929 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 320388002930 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 320388002931 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 320388002932 Nucleoside recognition; Region: Gate; pfam07670 320388002933 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 320388002934 deoxyribose-phosphate aldolase; Provisional; Region: PRK05283 320388002935 catalytic residue [active] 320388002936 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 320388002937 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320388002938 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 320388002939 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 320388002940 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 320388002941 active site 320388002942 catalytic motif [active] 320388002943 Zn binding site [ion binding]; other site 320388002944 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320388002945 BON domain; Region: BON; pfam04972 320388002946 BON domain; Region: BON; pfam04972 320388002947 6-phosphofructokinase 2; Provisional; Region: PRK10294 320388002948 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 320388002949 putative substrate binding site [chemical binding]; other site 320388002950 putative ATP binding site [chemical binding]; other site 320388002951 acetate kinase; Provisional; Region: PRK07058 320388002952 propionate/acetate kinase; Provisional; Region: PRK12379 320388002953 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 320388002954 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 320388002955 dimer interaction site [polypeptide binding]; other site 320388002956 substrate-binding tunnel; other site 320388002957 active site 320388002958 catalytic site [active] 320388002959 substrate binding site [chemical binding]; other site 320388002960 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 320388002961 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 320388002962 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 320388002963 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 320388002964 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 320388002965 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320388002966 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 320388002967 alpha subunit interaction interface [polypeptide binding]; other site 320388002968 Walker A motif; other site 320388002969 ATP binding site [chemical binding]; other site 320388002970 Walker B motif; other site 320388002971 inhibitor binding site; inhibition site 320388002972 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320388002973 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 320388002974 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 320388002975 gamma subunit interface [polypeptide binding]; other site 320388002976 epsilon subunit interface [polypeptide binding]; other site 320388002977 LBP interface [polypeptide binding]; other site 320388002978 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 320388002979 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 320388002980 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 320388002981 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 320388002982 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320388002983 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 320388002984 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320388002985 Walker A motif; other site 320388002986 ATP binding site [chemical binding]; other site 320388002987 Walker B motif; other site 320388002988 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320388002989 ATP synthase; Region: ATP-synt; pfam00231 320388002990 core domain interface [polypeptide binding]; other site 320388002991 delta subunit interface [polypeptide binding]; other site 320388002992 epsilon subunit interface [polypeptide binding]; other site 320388002993 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320388002994 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 320388002995 NAD binding site [chemical binding]; other site 320388002996 substrate binding site [chemical binding]; other site 320388002997 catalytic Zn binding site [ion binding]; other site 320388002998 tetramer interface [polypeptide binding]; other site 320388002999 structural Zn binding site [ion binding]; other site 320388003000 Cache domain; Region: Cache_2; pfam08269 320388003001 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388003002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388003003 dimer interface [polypeptide binding]; other site 320388003004 putative CheW interface [polypeptide binding]; other site 320388003005 PAS fold; Region: PAS_4; pfam08448 320388003006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388003007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388003008 dimer interface [polypeptide binding]; other site 320388003009 phosphorylation site [posttranslational modification] 320388003010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388003011 ATP binding site [chemical binding]; other site 320388003012 Mg2+ binding site [ion binding]; other site 320388003013 G-X-G motif; other site 320388003014 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320388003015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388003016 active site 320388003017 phosphorylation site [posttranslational modification] 320388003018 intermolecular recognition site; other site 320388003019 dimerization interface [polypeptide binding]; other site 320388003020 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 320388003021 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320388003022 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320388003023 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 320388003024 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320388003025 Walker A/P-loop; other site 320388003026 ATP binding site [chemical binding]; other site 320388003027 Q-loop/lid; other site 320388003028 ABC transporter signature motif; other site 320388003029 Walker B; other site 320388003030 D-loop; other site 320388003031 H-loop/switch region; other site 320388003032 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320388003033 Walker A/P-loop; other site 320388003034 ATP binding site [chemical binding]; other site 320388003035 Q-loop/lid; other site 320388003036 ABC transporter signature motif; other site 320388003037 Walker B; other site 320388003038 D-loop; other site 320388003039 H-loop/switch region; other site 320388003040 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320388003041 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320388003042 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388003043 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388003044 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388003045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388003046 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320388003047 Ligand Binding Site [chemical binding]; other site 320388003048 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 320388003049 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 320388003050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320388003051 FtsX-like permease family; Region: FtsX; pfam02687 320388003052 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320388003053 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320388003054 Walker A/P-loop; other site 320388003055 ATP binding site [chemical binding]; other site 320388003056 Q-loop/lid; other site 320388003057 ABC transporter signature motif; other site 320388003058 Walker B; other site 320388003059 D-loop; other site 320388003060 H-loop/switch region; other site 320388003061 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 320388003062 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388003063 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388003064 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320388003065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 320388003066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388003067 dimer interface [polypeptide binding]; other site 320388003068 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 320388003069 putative CheW interface [polypeptide binding]; other site 320388003070 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320388003071 ligand-binding site [chemical binding]; other site 320388003072 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 320388003073 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320388003074 BON domain; Region: BON; pfam04972 320388003075 BON domain; Region: BON; pfam04972 320388003076 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 320388003077 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 320388003078 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 320388003079 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320388003080 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 320388003081 putative NAD(P) binding site [chemical binding]; other site 320388003082 putative substrate binding site [chemical binding]; other site 320388003083 catalytic Zn binding site [ion binding]; other site 320388003084 structural Zn binding site [ion binding]; other site 320388003085 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 320388003086 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320388003087 ligand binding site [chemical binding]; other site 320388003088 flexible hinge region; other site 320388003089 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320388003090 putative switch regulator; other site 320388003091 non-specific DNA interactions [nucleotide binding]; other site 320388003092 DNA binding site [nucleotide binding] 320388003093 sequence specific DNA binding site [nucleotide binding]; other site 320388003094 putative cAMP binding site [chemical binding]; other site 320388003095 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 320388003096 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320388003097 NAD(P) binding site [chemical binding]; other site 320388003098 homotetramer interface [polypeptide binding]; other site 320388003099 homodimer interface [polypeptide binding]; other site 320388003100 active site 320388003101 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 320388003102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320388003103 Beta-Casp domain; Region: Beta-Casp; smart01027 320388003104 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 320388003105 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320388003106 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320388003107 Transposase domain (DUF772); Region: DUF772; pfam05598 320388003108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388003109 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388003110 lysine transporter; Provisional; Region: PRK10836 320388003111 HTH-like domain; Region: HTH_21; pfam13276 320388003112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388003113 Integrase core domain; Region: rve; pfam00665 320388003114 Integrase core domain; Region: rve_3; pfam13683 320388003115 Transposase; Region: HTH_Tnp_1; pfam01527 320388003116 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 320388003117 Asp-box motif; other site 320388003118 Isochorismatase family; Region: Isochorismatase; pfam00857 320388003119 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 320388003120 catalytic triad [active] 320388003121 conserved cis-peptide bond; other site 320388003122 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320388003123 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 320388003124 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 320388003125 nucleophilic elbow; other site 320388003126 catalytic triad; other site 320388003127 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 320388003128 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 320388003129 putative NAD(P) binding site [chemical binding]; other site 320388003130 active site 320388003131 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 320388003132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388003133 catalytic loop [active] 320388003134 iron binding site [ion binding]; other site 320388003135 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 320388003136 FAD binding pocket [chemical binding]; other site 320388003137 FAD binding motif [chemical binding]; other site 320388003138 phosphate binding motif [ion binding]; other site 320388003139 beta-alpha-beta structure motif; other site 320388003140 NAD binding pocket [chemical binding]; other site 320388003141 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 320388003142 inter-subunit interface; other site 320388003143 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 320388003144 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 320388003145 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 320388003146 putative alpha subunit interface [polypeptide binding]; other site 320388003147 putative active site [active] 320388003148 putative substrate binding site [chemical binding]; other site 320388003149 Fe binding site [ion binding]; other site 320388003150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388003151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003152 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 320388003153 dimerizarion interface [polypeptide binding]; other site 320388003154 CrgA pocket; other site 320388003155 substrate binding pocket [chemical binding]; other site 320388003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388003157 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388003158 NAD(P) binding site [chemical binding]; other site 320388003159 active site 320388003160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388003161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388003163 dimerization interface [polypeptide binding]; other site 320388003164 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320388003165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388003166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388003167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320388003168 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 320388003169 active site 320388003170 FMN binding site [chemical binding]; other site 320388003171 2,4-decadienoyl-CoA binding site; other site 320388003172 catalytic residue [active] 320388003173 4Fe-4S cluster binding site [ion binding]; other site 320388003174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320388003175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388003176 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 320388003177 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320388003178 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 320388003179 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320388003180 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 320388003181 D-pathway; other site 320388003182 Putative ubiquinol binding site [chemical binding]; other site 320388003183 Low-spin heme (heme b) binding site [chemical binding]; other site 320388003184 Putative water exit pathway; other site 320388003185 Binuclear center (heme o3/CuB) [ion binding]; other site 320388003186 K-pathway; other site 320388003187 Putative proton exit pathway; other site 320388003188 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 320388003189 Subunit I/III interface [polypeptide binding]; other site 320388003190 Subunit III/IV interface [polypeptide binding]; other site 320388003191 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 320388003192 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 320388003193 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 320388003194 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 320388003195 dimer interface [polypeptide binding]; other site 320388003196 active site 320388003197 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 320388003198 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 320388003199 octamer interface [polypeptide binding]; other site 320388003200 active site 320388003201 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320388003202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388003204 dimerization interface [polypeptide binding]; other site 320388003205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388003206 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 320388003207 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 320388003208 putative alpha subunit interface [polypeptide binding]; other site 320388003209 putative active site [active] 320388003210 putative substrate binding site [chemical binding]; other site 320388003211 Fe binding site [ion binding]; other site 320388003212 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 320388003213 inter-subunit interface; other site 320388003214 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 320388003215 [2Fe-2S] cluster binding site [ion binding]; other site 320388003216 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 320388003217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388003218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388003219 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 320388003220 HIT family signature motif; other site 320388003221 catalytic residue [active] 320388003222 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 320388003223 PLD-like domain; Region: PLDc_2; pfam13091 320388003224 putative active site [active] 320388003225 catalytic site [active] 320388003226 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 320388003227 PLD-like domain; Region: PLDc_2; pfam13091 320388003228 putative active site [active] 320388003229 catalytic site [active] 320388003230 Protein of unknown function (DUF445); Region: DUF445; pfam04286 320388003231 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 320388003232 acetolactate synthase; Reviewed; Region: PRK08322 320388003233 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388003234 PYR/PP interface [polypeptide binding]; other site 320388003235 dimer interface [polypeptide binding]; other site 320388003236 TPP binding site [chemical binding]; other site 320388003237 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388003238 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 320388003239 TPP-binding site [chemical binding]; other site 320388003240 dimer interface [polypeptide binding]; other site 320388003241 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 320388003242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388003243 NAD(P) binding site [chemical binding]; other site 320388003244 catalytic residues [active] 320388003245 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 320388003246 active site 320388003247 catalytic site [active] 320388003248 Response regulator receiver domain; Region: Response_reg; pfam00072 320388003249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388003250 active site 320388003251 phosphorylation site [posttranslational modification] 320388003252 intermolecular recognition site; other site 320388003253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388003254 dimerization interface [polypeptide binding]; other site 320388003255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388003256 dimer interface [polypeptide binding]; other site 320388003257 phosphorylation site [posttranslational modification] 320388003258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388003259 ATP binding site [chemical binding]; other site 320388003260 Mg2+ binding site [ion binding]; other site 320388003261 G-X-G motif; other site 320388003262 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320388003263 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 320388003264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388003265 dimerization interface [polypeptide binding]; other site 320388003266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388003267 dimer interface [polypeptide binding]; other site 320388003268 putative CheW interface [polypeptide binding]; other site 320388003269 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 320388003270 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 320388003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388003272 S-adenosylmethionine binding site [chemical binding]; other site 320388003273 TPR repeat; Region: TPR_11; pfam13414 320388003274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388003275 binding surface 320388003276 TPR motif; other site 320388003277 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 320388003278 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 320388003279 putative binding surface; other site 320388003280 active site 320388003281 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 320388003282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388003283 ATP binding site [chemical binding]; other site 320388003284 Mg2+ binding site [ion binding]; other site 320388003285 G-X-G motif; other site 320388003286 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 320388003287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388003288 Response regulator receiver domain; Region: Response_reg; pfam00072 320388003289 active site 320388003290 phosphorylation site [posttranslational modification] 320388003291 intermolecular recognition site; other site 320388003292 dimerization interface [polypeptide binding]; other site 320388003293 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 320388003294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388003295 active site 320388003296 phosphorylation site [posttranslational modification] 320388003297 intermolecular recognition site; other site 320388003298 CheB methylesterase; Region: CheB_methylest; pfam01339 320388003299 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 320388003300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388003301 motif II; other site 320388003302 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 320388003303 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320388003304 Cl- selectivity filter; other site 320388003305 Cl- binding residues [ion binding]; other site 320388003306 pore gating glutamate residue; other site 320388003307 dimer interface [polypeptide binding]; other site 320388003308 CAAX protease self-immunity; Region: Abi; pfam02517 320388003309 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 320388003310 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 320388003311 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 320388003312 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 320388003313 active site 320388003314 HIGH motif; other site 320388003315 dimer interface [polypeptide binding]; other site 320388003316 KMSKS motif; other site 320388003317 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320388003318 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388003319 conserved cys residue [active] 320388003320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388003321 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320388003322 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 320388003323 conserved cys residue [active] 320388003324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320388003325 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320388003326 Walker A/P-loop; other site 320388003327 ATP binding site [chemical binding]; other site 320388003328 Q-loop/lid; other site 320388003329 ABC transporter signature motif; other site 320388003330 Walker B; other site 320388003331 D-loop; other site 320388003332 H-loop/switch region; other site 320388003333 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 320388003334 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 320388003335 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 320388003336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388003337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003338 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320388003339 substrate binding pocket [chemical binding]; other site 320388003340 dimerization interface [polypeptide binding]; other site 320388003341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388003342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388003343 active site 320388003344 Phosphotransferase enzyme family; Region: APH; pfam01636 320388003345 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 320388003346 putative active site [active] 320388003347 putative substrate binding site [chemical binding]; other site 320388003348 ATP binding site [chemical binding]; other site 320388003349 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388003350 catalytic core [active] 320388003351 short chain dehydrogenase; Provisional; Region: PRK07035 320388003352 classical (c) SDRs; Region: SDR_c; cd05233 320388003353 NAD(P) binding site [chemical binding]; other site 320388003354 active site 320388003355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388003356 short chain dehydrogenase; Validated; Region: PRK07069 320388003357 NAD(P) binding site [chemical binding]; other site 320388003358 active site 320388003359 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320388003360 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320388003361 NAD(P) binding site [chemical binding]; other site 320388003362 substrate binding site [chemical binding]; other site 320388003363 dimer interface [polypeptide binding]; other site 320388003364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388003365 putative substrate translocation pore; other site 320388003366 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388003367 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 320388003368 N-terminal plug; other site 320388003369 ligand-binding site [chemical binding]; other site 320388003370 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320388003371 Domain of unknown function DUF20; Region: UPF0118; pfam01594 320388003372 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 320388003373 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 320388003374 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 320388003375 generic binding surface I; other site 320388003376 generic binding surface II; other site 320388003377 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 320388003378 putative active site [active] 320388003379 putative catalytic site [active] 320388003380 putative Mg binding site IVb [ion binding]; other site 320388003381 putative phosphate binding site [ion binding]; other site 320388003382 putative DNA binding site [nucleotide binding]; other site 320388003383 putative Mg binding site IVa [ion binding]; other site 320388003384 YCII-related domain; Region: YCII; cl00999 320388003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 320388003386 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 320388003387 putative hydrophobic ligand binding site [chemical binding]; other site 320388003388 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 320388003389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388003390 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320388003391 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320388003392 amidase catalytic site [active] 320388003393 Zn binding residues [ion binding]; other site 320388003394 substrate binding site [chemical binding]; other site 320388003395 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320388003396 Rubrerythrin [Energy production and conversion]; Region: COG1592 320388003397 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 320388003398 binuclear metal center [ion binding]; other site 320388003399 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320388003400 Cysteine-rich domain; Region: CCG; pfam02754 320388003401 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 320388003402 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320388003403 Cupin domain; Region: Cupin_2; cl17218 320388003404 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320388003405 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 320388003406 Substrate binding site; other site 320388003407 Cupin domain; Region: Cupin_2; cl17218 320388003408 CoA-binding domain; Region: CoA_binding_3; pfam13727 320388003409 Bacterial sugar transferase; Region: Bac_transf; cl00939 320388003410 Transposase; Region: HTH_Tnp_1; pfam01527 320388003411 HTH-like domain; Region: HTH_21; pfam13276 320388003412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388003413 Integrase core domain; Region: rve; pfam00665 320388003414 Integrase core domain; Region: rve_3; pfam13683 320388003415 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320388003416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388003417 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388003418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388003419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388003420 Homeodomain-like domain; Region: HTH_23; pfam13384 320388003421 Winged helix-turn helix; Region: HTH_29; pfam13551 320388003422 Winged helix-turn helix; Region: HTH_33; pfam13592 320388003423 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320388003424 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 320388003425 phosphate binding site [ion binding]; other site 320388003426 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 320388003427 putative deacylase active site [active] 320388003428 Methyltransferase domain; Region: Methyltransf_11; pfam08241 320388003429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320388003430 DNA binding residues [nucleotide binding] 320388003431 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 320388003432 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 320388003433 active site 320388003434 catalytic site [active] 320388003435 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 320388003436 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 320388003437 thiamine phosphate binding site [chemical binding]; other site 320388003438 active site 320388003439 pyrophosphate binding site [ion binding]; other site 320388003440 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 320388003441 Domain of unknown function DUF21; Region: DUF21; pfam01595 320388003442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320388003443 Transporter associated domain; Region: CorC_HlyC; smart01091 320388003444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388003445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388003446 dimer interface [polypeptide binding]; other site 320388003447 phosphorylation site [posttranslational modification] 320388003448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 320388003449 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388003450 EamA-like transporter family; Region: EamA; pfam00892 320388003451 EamA-like transporter family; Region: EamA; cl17759 320388003452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388003453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388003455 dimerization interface [polypeptide binding]; other site 320388003456 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 320388003457 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 320388003458 dimer interface [polypeptide binding]; other site 320388003459 hexamer interface [polypeptide binding]; other site 320388003460 active site 2 [active] 320388003461 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 320388003462 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 320388003463 molybdenum-pterin binding domain; Region: Mop; TIGR00638 320388003464 TOBE domain; Region: TOBE; cl01440 320388003465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388003466 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 320388003467 Walker A/P-loop; other site 320388003468 ATP binding site [chemical binding]; other site 320388003469 Q-loop/lid; other site 320388003470 ABC transporter signature motif; other site 320388003471 Walker B; other site 320388003472 D-loop; other site 320388003473 H-loop/switch region; other site 320388003474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388003475 putative PBP binding loops; other site 320388003476 dimer interface [polypeptide binding]; other site 320388003477 ABC-ATPase subunit interface; other site 320388003478 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320388003479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320388003480 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 320388003481 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 320388003482 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 320388003483 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320388003484 MarR family; Region: MarR; pfam01047 320388003485 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 320388003486 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 320388003487 putative active site [active] 320388003488 putative substrate binding site [chemical binding]; other site 320388003489 ATP binding site [chemical binding]; other site 320388003490 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 320388003491 AMP nucleosidase; Provisional; Region: PRK08292 320388003492 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 320388003493 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 320388003494 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320388003495 active site 320388003496 Int/Topo IB signature motif; other site 320388003497 DNA binding site [nucleotide binding] 320388003498 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 320388003499 Uncharacterized conserved protein [Function unknown]; Region: COG1683 320388003500 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 320388003501 DNA polymerase I; Provisional; Region: PRK05755 320388003502 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 320388003503 active site 320388003504 metal binding site 1 [ion binding]; metal-binding site 320388003505 putative 5' ssDNA interaction site; other site 320388003506 metal binding site 3; metal-binding site 320388003507 metal binding site 2 [ion binding]; metal-binding site 320388003508 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 320388003509 putative DNA binding site [nucleotide binding]; other site 320388003510 putative metal binding site [ion binding]; other site 320388003511 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 320388003512 active site 320388003513 catalytic site [active] 320388003514 substrate binding site [chemical binding]; other site 320388003515 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 320388003516 active site 320388003517 DNA binding site [nucleotide binding] 320388003518 catalytic site [active] 320388003519 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 320388003520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388003521 Predicted membrane protein [Function unknown]; Region: COG4655 320388003522 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 320388003523 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 320388003524 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 320388003525 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 320388003526 active site residue [active] 320388003527 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 320388003528 active site residue [active] 320388003529 Transposase domain (DUF772); Region: DUF772; pfam05598 320388003530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388003531 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388003532 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320388003533 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320388003534 [2Fe-2S] cluster binding site [ion binding]; other site 320388003535 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320388003536 alpha subunit interface [polypeptide binding]; other site 320388003537 active site 320388003538 substrate binding site [chemical binding]; other site 320388003539 Fe binding site [ion binding]; other site 320388003540 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 320388003541 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320388003542 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320388003543 substrate binding pocket [chemical binding]; other site 320388003544 chain length determination region; other site 320388003545 substrate-Mg2+ binding site; other site 320388003546 catalytic residues [active] 320388003547 aspartate-rich region 1; other site 320388003548 active site lid residues [active] 320388003549 aspartate-rich region 2; other site 320388003550 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 320388003551 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 320388003552 TPP-binding site; other site 320388003553 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320388003554 PYR/PP interface [polypeptide binding]; other site 320388003555 dimer interface [polypeptide binding]; other site 320388003556 TPP binding site [chemical binding]; other site 320388003557 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320388003558 putative GTP cyclohydrolase; Provisional; Region: PRK13674 320388003559 UGMP family protein; Validated; Region: PRK09604 320388003560 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320388003561 Predicted flavoproteins [General function prediction only]; Region: COG2081 320388003562 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320388003563 Yqey-like protein; Region: YqeY; pfam09424 320388003564 DNA primase; Validated; Region: dnaG; PRK05667 320388003565 CHC2 zinc finger; Region: zf-CHC2; pfam01807 320388003566 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 320388003567 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 320388003568 active site 320388003569 metal binding site [ion binding]; metal-binding site 320388003570 interdomain interaction site; other site 320388003571 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 320388003572 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 320388003573 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 320388003574 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 320388003575 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320388003576 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 320388003577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388003578 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320388003579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388003580 DNA binding residues [nucleotide binding] 320388003581 Transposase domain (DUF772); Region: DUF772; pfam05598 320388003582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388003583 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388003584 HTH-like domain; Region: HTH_21; pfam13276 320388003585 Integrase core domain; Region: rve; pfam00665 320388003586 HTH-like domain; Region: HTH_21; pfam13276 320388003587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388003588 Integrase core domain; Region: rve; pfam00665 320388003589 Integrase core domain; Region: rve_3; pfam13683 320388003590 Transposase; Region: HTH_Tnp_1; pfam01527 320388003591 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 320388003592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003593 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320388003594 substrate binding pocket [chemical binding]; other site 320388003595 dimerization interface [polypeptide binding]; other site 320388003596 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 320388003597 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 320388003598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388003599 putative substrate translocation pore; other site 320388003600 POT family; Region: PTR2; cl17359 320388003601 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 320388003602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388003603 non-specific DNA binding site [nucleotide binding]; other site 320388003604 salt bridge; other site 320388003605 sequence-specific DNA binding site [nucleotide binding]; other site 320388003606 Cupin domain; Region: Cupin_2; pfam07883 320388003607 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 320388003608 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 320388003609 peptide binding site [polypeptide binding]; other site 320388003610 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 320388003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388003612 dimer interface [polypeptide binding]; other site 320388003613 conserved gate region; other site 320388003614 putative PBP binding loops; other site 320388003615 ABC-ATPase subunit interface; other site 320388003616 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 320388003617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388003618 dimer interface [polypeptide binding]; other site 320388003619 conserved gate region; other site 320388003620 putative PBP binding loops; other site 320388003621 ABC-ATPase subunit interface; other site 320388003622 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 320388003623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388003624 Walker A/P-loop; other site 320388003625 ATP binding site [chemical binding]; other site 320388003626 Q-loop/lid; other site 320388003627 ABC transporter signature motif; other site 320388003628 Walker B; other site 320388003629 D-loop; other site 320388003630 H-loop/switch region; other site 320388003631 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388003632 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 320388003633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388003634 Walker A/P-loop; other site 320388003635 ATP binding site [chemical binding]; other site 320388003636 Q-loop/lid; other site 320388003637 ABC transporter signature motif; other site 320388003638 Walker B; other site 320388003639 D-loop; other site 320388003640 H-loop/switch region; other site 320388003641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388003642 outer membrane porin, OprD family; Region: OprD; pfam03573 320388003643 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 320388003644 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 320388003645 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 320388003646 active site residue [active] 320388003647 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 320388003648 PAS fold; Region: PAS_4; pfam08448 320388003649 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388003650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388003651 Walker B motif; other site 320388003652 arginine finger; other site 320388003653 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388003654 H-NS histone family; Region: Histone_HNS; pfam00816 320388003655 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388003656 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 320388003657 CoA binding domain; Region: CoA_binding_2; pfam13380 320388003658 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 320388003659 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 320388003660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320388003661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388003662 Coenzyme A binding pocket [chemical binding]; other site 320388003663 indole acetimide hydrolase; Validated; Region: PRK07488 320388003664 Amidase; Region: Amidase; pfam01425 320388003665 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388003666 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320388003667 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388003668 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320388003669 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320388003670 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 320388003671 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320388003672 phosphate binding site [ion binding]; other site 320388003673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388003675 dimerization interface [polypeptide binding]; other site 320388003676 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388003677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388003678 putative substrate translocation pore; other site 320388003679 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 320388003680 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 320388003681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388003682 catalytic residue [active] 320388003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388003684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388003685 putative substrate translocation pore; other site 320388003686 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320388003687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388003688 dimerization interface [polypeptide binding]; other site 320388003689 putative DNA binding site [nucleotide binding]; other site 320388003690 putative Zn2+ binding site [ion binding]; other site 320388003691 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 320388003692 active site residue [active] 320388003693 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388003694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388003696 dimerization interface [polypeptide binding]; other site 320388003697 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 320388003698 catalytic residue [active] 320388003699 D-serine dehydratase; Provisional; Region: PRK02991 320388003700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388003701 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388003702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388003703 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320388003704 dimerization interface [polypeptide binding]; other site 320388003705 substrate binding pocket [chemical binding]; other site 320388003706 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 320388003707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388003708 NAD(P) binding site [chemical binding]; other site 320388003709 active site 320388003710 hypothetical protein; Provisional; Region: PRK07538 320388003711 hypothetical protein; Provisional; Region: PRK07236 320388003712 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 320388003713 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 320388003714 phosphopeptide binding site; other site 320388003715 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320388003716 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320388003717 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320388003718 hypothetical protein; Provisional; Region: PRK07033 320388003719 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320388003720 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388003721 ligand binding site [chemical binding]; other site 320388003722 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320388003723 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 320388003724 G1 box; other site 320388003725 GTP/Mg2+ binding site [chemical binding]; other site 320388003726 G2 box; other site 320388003727 G3 box; other site 320388003728 Switch II region; other site 320388003729 G4 box; other site 320388003730 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388003731 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320388003732 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 320388003733 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 320388003734 Catalytic domain of Protein Kinases; Region: PKc; cd00180 320388003735 active site 320388003736 ATP binding site [chemical binding]; other site 320388003737 substrate binding site [chemical binding]; other site 320388003738 activation loop (A-loop); other site 320388003739 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320388003740 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320388003741 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320388003742 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320388003743 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320388003744 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320388003745 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 320388003746 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388003747 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320388003748 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 320388003749 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320388003750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388003751 Walker A motif; other site 320388003752 ATP binding site [chemical binding]; other site 320388003753 Walker B motif; other site 320388003754 arginine finger; other site 320388003755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388003756 Walker A motif; other site 320388003757 ATP binding site [chemical binding]; other site 320388003758 Walker B motif; other site 320388003759 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320388003760 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320388003761 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388003762 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388003763 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 320388003764 RHS Repeat; Region: RHS_repeat; cl11982 320388003765 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320388003766 RHS Repeat; Region: RHS_repeat; cl11982 320388003767 RHS Repeat; Region: RHS_repeat; cl11982 320388003768 RHS Repeat; Region: RHS_repeat; cl11982 320388003769 RHS Repeat; Region: RHS_repeat; cl11982 320388003770 HTH-like domain; Region: HTH_21; pfam13276 320388003771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388003772 Integrase core domain; Region: rve; pfam00665 320388003773 Integrase core domain; Region: rve_3; pfam13683 320388003774 Transposase; Region: HTH_Tnp_1; pfam01527 320388003775 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 320388003776 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 320388003777 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 320388003778 haemagglutination activity domain; Region: Haemagg_act; pfam05860 320388003779 Inositol polyphosphate kinase; Region: IPK; cl12283 320388003780 aconitate hydratase; Provisional; Region: acnA; PRK12881 320388003781 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 320388003782 substrate binding site [chemical binding]; other site 320388003783 ligand binding site [chemical binding]; other site 320388003784 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 320388003785 substrate binding site [chemical binding]; other site 320388003786 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 320388003787 2-methylcitrate dehydratase; Region: prpD; TIGR02330 320388003788 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 320388003789 malate dehydrogenase; Provisional; Region: PRK05442 320388003790 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 320388003791 NAD(P) binding site [chemical binding]; other site 320388003792 dimer interface [polypeptide binding]; other site 320388003793 malate binding site [chemical binding]; other site 320388003794 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320388003795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388003796 DNA-binding site [nucleotide binding]; DNA binding site 320388003797 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 320388003798 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 320388003799 Iron-sulfur protein interface; other site 320388003800 proximal quinone binding site [chemical binding]; other site 320388003801 SdhD (CybS) interface [polypeptide binding]; other site 320388003802 proximal heme binding site [chemical binding]; other site 320388003803 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 320388003804 SdhC subunit interface [polypeptide binding]; other site 320388003805 proximal heme binding site [chemical binding]; other site 320388003806 cardiolipin binding site; other site 320388003807 Iron-sulfur protein interface; other site 320388003808 proximal quinone binding site [chemical binding]; other site 320388003809 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 320388003810 L-aspartate oxidase; Provisional; Region: PRK06175 320388003811 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 320388003812 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 320388003813 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 320388003814 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 320388003815 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 320388003816 dimer interface [polypeptide binding]; other site 320388003817 active site 320388003818 citrylCoA binding site [chemical binding]; other site 320388003819 NADH binding [chemical binding]; other site 320388003820 cationic pore residues; other site 320388003821 oxalacetate/citrate binding site [chemical binding]; other site 320388003822 coenzyme A binding site [chemical binding]; other site 320388003823 catalytic triad [active] 320388003824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388003825 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388003826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 320388003827 HTH-like domain; Region: HTH_21; pfam13276 320388003828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388003829 Integrase core domain; Region: rve; pfam00665 320388003830 Integrase core domain; Region: rve_3; pfam13683 320388003831 Transposase; Region: HTH_Tnp_1; pfam01527 320388003832 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 320388003833 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 320388003834 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 320388003835 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 320388003836 dimer interface [polypeptide binding]; other site 320388003837 TPP-binding site [chemical binding]; other site 320388003838 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 320388003839 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388003840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388003841 putative DNA binding site [nucleotide binding]; other site 320388003842 putative Zn2+ binding site [ion binding]; other site 320388003843 AsnC family; Region: AsnC_trans_reg; pfam01037 320388003844 cyclase homology domain; Region: CHD; cd07302 320388003845 nucleotidyl binding site; other site 320388003846 metal binding site [ion binding]; metal-binding site 320388003847 dimer interface [polypeptide binding]; other site 320388003848 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320388003849 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320388003850 active site 320388003851 non-prolyl cis peptide bond; other site 320388003852 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 320388003853 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 320388003854 substrate binding site [chemical binding]; other site 320388003855 ligand binding site [chemical binding]; other site 320388003856 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 320388003857 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 320388003858 substrate binding site [chemical binding]; other site 320388003859 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 320388003860 tartrate dehydrogenase; Region: TTC; TIGR02089 320388003861 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 320388003862 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320388003863 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 320388003864 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 320388003865 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 320388003866 dimerization interface 3.5A [polypeptide binding]; other site 320388003867 active site 320388003868 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 320388003869 active site 320388003870 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 320388003871 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 320388003872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388003873 catalytic residue [active] 320388003874 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 320388003875 DNA methylase; Region: N6_N4_Mtase; pfam01555 320388003876 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 320388003877 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 320388003878 substrate binding site [chemical binding]; other site 320388003879 active site 320388003880 catalytic residues [active] 320388003881 heterodimer interface [polypeptide binding]; other site 320388003882 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 320388003883 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 320388003884 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 320388003885 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388003886 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388003887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 320388003888 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 320388003889 Colicin V production protein; Region: Colicin_V; pfam02674 320388003890 amidophosphoribosyltransferase; Provisional; Region: PRK09246 320388003891 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 320388003892 active site 320388003893 tetramer interface [polypeptide binding]; other site 320388003894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388003895 active site 320388003896 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 320388003897 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 320388003898 homodimer interface [polypeptide binding]; other site 320388003899 substrate-cofactor binding pocket; other site 320388003900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388003901 catalytic residue [active] 320388003902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388003903 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388003904 NAD(P) binding site [chemical binding]; other site 320388003905 active site 320388003906 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 320388003907 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 320388003908 NADP-binding site; other site 320388003909 homotetramer interface [polypeptide binding]; other site 320388003910 substrate binding site [chemical binding]; other site 320388003911 homodimer interface [polypeptide binding]; other site 320388003912 active site 320388003913 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320388003914 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 320388003915 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 320388003916 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 320388003917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388003918 putative ADP-binding pocket [chemical binding]; other site 320388003919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320388003920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388003921 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320388003922 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 320388003923 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 320388003924 active site 320388003925 tetramer interface; other site 320388003926 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320388003927 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388003928 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388003929 trimer interface [polypeptide binding]; other site 320388003930 eyelet of channel; other site 320388003931 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 320388003932 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 320388003933 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 320388003934 putative active site [active] 320388003935 Zn binding site [ion binding]; other site 320388003936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388003937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388003938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388003939 substrate binding pocket [chemical binding]; other site 320388003940 membrane-bound complex binding site; other site 320388003941 hinge residues; other site 320388003942 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 320388003943 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 320388003944 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320388003945 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320388003946 active site 320388003947 non-prolyl cis peptide bond; other site 320388003948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388003949 dimer interface [polypeptide binding]; other site 320388003950 conserved gate region; other site 320388003951 putative PBP binding loops; other site 320388003952 ABC-ATPase subunit interface; other site 320388003953 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320388003954 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388003955 Walker A/P-loop; other site 320388003956 ATP binding site [chemical binding]; other site 320388003957 Q-loop/lid; other site 320388003958 ABC transporter signature motif; other site 320388003959 Walker B; other site 320388003960 D-loop; other site 320388003961 H-loop/switch region; other site 320388003962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388003963 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388003964 substrate binding pocket [chemical binding]; other site 320388003965 membrane-bound complex binding site; other site 320388003966 hinge residues; other site 320388003967 Uncharacterized conserved protein [Function unknown]; Region: COG1434 320388003968 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 320388003969 putative active site [active] 320388003970 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388003971 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388003972 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388003973 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 320388003974 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 320388003975 molybdopterin cofactor binding site; other site 320388003976 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 320388003977 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 320388003978 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 320388003979 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 320388003980 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 320388003981 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 320388003982 selenocysteine synthase; Provisional; Region: PRK04311 320388003983 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 320388003984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388003985 catalytic residue [active] 320388003986 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 320388003987 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 320388003988 G1 box; other site 320388003989 putative GEF interaction site [polypeptide binding]; other site 320388003990 GTP/Mg2+ binding site [chemical binding]; other site 320388003991 Switch I region; other site 320388003992 G2 box; other site 320388003993 G3 box; other site 320388003994 Switch II region; other site 320388003995 G4 box; other site 320388003996 G5 box; other site 320388003997 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 320388003998 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 320388003999 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 320388004000 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 320388004001 Amidase; Region: Amidase; cl11426 320388004002 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 320388004003 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 320388004004 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 320388004005 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320388004006 H+ Antiporter protein; Region: 2A0121; TIGR00900 320388004007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004008 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320388004009 Cytochrome P450; Region: p450; cl12078 320388004010 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320388004011 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 320388004012 FMN-binding pocket [chemical binding]; other site 320388004013 flavin binding motif; other site 320388004014 phosphate binding motif [ion binding]; other site 320388004015 beta-alpha-beta structure motif; other site 320388004016 NAD binding pocket [chemical binding]; other site 320388004017 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388004018 catalytic loop [active] 320388004019 iron binding site [ion binding]; other site 320388004020 benzoate transport; Region: 2A0115; TIGR00895 320388004021 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 320388004022 active site 320388004023 nucleophile elbow; other site 320388004024 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320388004025 Cu(I) binding site [ion binding]; other site 320388004026 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 320388004027 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 320388004028 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320388004029 putative sugar binding sites [chemical binding]; other site 320388004030 Q-X-W motif; other site 320388004031 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 320388004032 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320388004033 putative sugar binding sites [chemical binding]; other site 320388004034 Q-X-W motif; other site 320388004035 Kelch motif; Region: Kelch_6; pfam13964 320388004036 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 320388004037 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 320388004038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388004039 active site 320388004040 phosphorylation site [posttranslational modification] 320388004041 intermolecular recognition site; other site 320388004042 dimerization interface [polypeptide binding]; other site 320388004043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320388004044 Zn2+ binding site [ion binding]; other site 320388004045 Mg2+ binding site [ion binding]; other site 320388004046 Uncharacterized conserved protein [Function unknown]; Region: COG3287 320388004047 FIST N domain; Region: FIST; pfam08495 320388004048 FIST C domain; Region: FIST_C; pfam10442 320388004049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388004050 ATP binding site [chemical binding]; other site 320388004051 Mg2+ binding site [ion binding]; other site 320388004052 G-X-G motif; other site 320388004053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 320388004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004055 putative substrate translocation pore; other site 320388004056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388004057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388004058 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388004059 putative effector binding pocket; other site 320388004060 dimerization interface [polypeptide binding]; other site 320388004061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388004062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388004063 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 320388004064 putative dimerization interface [polypeptide binding]; other site 320388004065 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 320388004066 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 320388004067 putative active site [active] 320388004068 putative catalytic site [active] 320388004069 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 320388004070 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 320388004071 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 320388004072 pyruvate dehydrogenase; Provisional; Region: PRK09124 320388004073 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 320388004074 PYR/PP interface [polypeptide binding]; other site 320388004075 tetramer interface [polypeptide binding]; other site 320388004076 dimer interface [polypeptide binding]; other site 320388004077 TPP binding site [chemical binding]; other site 320388004078 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388004079 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 320388004080 TPP-binding site [chemical binding]; other site 320388004081 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 320388004082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388004083 inhibitor-cofactor binding pocket; inhibition site 320388004084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388004085 catalytic residue [active] 320388004086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004087 putative substrate translocation pore; other site 320388004088 Condensation domain; Region: Condensation; pfam00668 320388004089 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320388004090 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388004091 acyl-activating enzyme (AAE) consensus motif; other site 320388004092 AMP binding site [chemical binding]; other site 320388004093 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388004094 Condensation domain; Region: Condensation; pfam00668 320388004095 HTH-like domain; Region: HTH_21; pfam13276 320388004096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004097 Integrase core domain; Region: rve; pfam00665 320388004098 Integrase core domain; Region: rve_3; pfam13683 320388004099 Transposase; Region: HTH_Tnp_1; pfam01527 320388004100 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004102 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004103 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 320388004104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388004105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388004106 homodimer interface [polypeptide binding]; other site 320388004107 catalytic residue [active] 320388004108 excinuclease ABC subunit B; Provisional; Region: PRK05298 320388004109 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 320388004110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388004111 ATP-binding site [chemical binding]; other site 320388004112 ATP binding site [chemical binding]; other site 320388004113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388004114 nucleotide binding region [chemical binding]; other site 320388004115 ATP-binding site [chemical binding]; other site 320388004116 Ultra-violet resistance protein B; Region: UvrB; pfam12344 320388004117 UvrB/uvrC motif; Region: UVR; pfam02151 320388004118 Fe2+ transport protein; Region: Iron_transport; pfam10634 320388004119 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 320388004120 Iron permease FTR1 family; Region: FTR1; cl00475 320388004121 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 320388004122 4Fe-4S binding domain; Region: Fer4_5; pfam12801 320388004123 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 320388004124 Transposase; Region: HTH_Tnp_1; pfam01527 320388004125 HTH-like domain; Region: HTH_21; pfam13276 320388004126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004127 Integrase core domain; Region: rve; pfam00665 320388004128 Integrase core domain; Region: rve_3; pfam13683 320388004129 Bacitracin resistance protein BacA; Region: BacA; cl00858 320388004130 HTH-like domain; Region: HTH_21; pfam13276 320388004131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004132 Integrase core domain; Region: rve; pfam00665 320388004133 Integrase core domain; Region: rve_3; pfam13683 320388004134 Transposase; Region: HTH_Tnp_1; pfam01527 320388004135 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 320388004136 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 320388004137 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 320388004138 dimer interface [polypeptide binding]; other site 320388004139 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 320388004140 active site 320388004141 Fe binding site [ion binding]; other site 320388004142 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 320388004143 Dehydroquinase class II; Region: DHquinase_II; pfam01220 320388004144 active site 320388004145 trimer interface [polypeptide binding]; other site 320388004146 dimer interface [polypeptide binding]; other site 320388004147 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 320388004148 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 320388004149 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 320388004150 shikimate binding site; other site 320388004151 NAD(P) binding site [chemical binding]; other site 320388004152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004153 D-galactonate transporter; Region: 2A0114; TIGR00893 320388004154 putative substrate translocation pore; other site 320388004155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004156 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 320388004157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388004158 catalytic residue [active] 320388004159 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 320388004160 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320388004161 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 320388004162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388004163 Walker A/P-loop; other site 320388004164 ATP binding site [chemical binding]; other site 320388004165 Q-loop/lid; other site 320388004166 ABC transporter signature motif; other site 320388004167 Walker B; other site 320388004168 D-loop; other site 320388004169 H-loop/switch region; other site 320388004170 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 320388004171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388004172 dimer interface [polypeptide binding]; other site 320388004173 conserved gate region; other site 320388004174 putative PBP binding loops; other site 320388004175 ABC-ATPase subunit interface; other site 320388004176 2-aminoethylphosphonate ABC transport system, membrane component PhnV; Region: PhnV; TIGR03255 320388004177 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 320388004178 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 320388004179 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 320388004180 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 320388004181 NAD(P) binding site [chemical binding]; other site 320388004182 catalytic residues [active] 320388004183 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 320388004184 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 320388004185 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 320388004186 dimer interface [polypeptide binding]; other site 320388004187 PYR/PP interface [polypeptide binding]; other site 320388004188 TPP binding site [chemical binding]; other site 320388004189 substrate binding site [chemical binding]; other site 320388004190 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 320388004191 TPP-binding site; other site 320388004192 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 320388004193 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 320388004194 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 320388004195 dimer interface [polypeptide binding]; other site 320388004196 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 320388004197 active site 320388004198 Fe binding site [ion binding]; other site 320388004199 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388004200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388004201 putative DNA binding site [nucleotide binding]; other site 320388004202 putative Zn2+ binding site [ion binding]; other site 320388004203 AsnC family; Region: AsnC_trans_reg; pfam01037 320388004204 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320388004205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388004206 Coenzyme A binding pocket [chemical binding]; other site 320388004207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388004208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388004209 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 320388004210 Protein of unknown function; Region: DUF3658; pfam12395 320388004211 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 320388004212 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 320388004213 FAD binding pocket [chemical binding]; other site 320388004214 FAD binding motif [chemical binding]; other site 320388004215 phosphate binding motif [ion binding]; other site 320388004216 beta-alpha-beta structure motif; other site 320388004217 NAD(p) ribose binding residues [chemical binding]; other site 320388004218 NAD binding pocket [chemical binding]; other site 320388004219 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 320388004220 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388004221 catalytic loop [active] 320388004222 iron binding site [ion binding]; other site 320388004223 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 320388004224 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 320388004225 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 320388004226 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 320388004227 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 320388004228 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 320388004229 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 320388004230 active site 320388004231 catalytic triad [active] 320388004232 oxyanion hole [active] 320388004233 Transposase; Region: HTH_Tnp_1; pfam01527 320388004234 HTH-like domain; Region: HTH_21; pfam13276 320388004235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004236 Integrase core domain; Region: rve; pfam00665 320388004237 Integrase core domain; Region: rve_3; pfam13683 320388004238 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320388004239 Cytochrome c; Region: Cytochrom_C; cl11414 320388004240 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320388004241 BON domain; Region: BON; pfam04972 320388004242 BON domain; Region: BON; pfam04972 320388004243 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 320388004244 dimer interface [polypeptide binding]; other site 320388004245 active site 320388004246 hypothetical protein; Provisional; Region: PRK14673 320388004247 Predicted methyltransferases [General function prediction only]; Region: COG0313 320388004248 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 320388004249 putative SAM binding site [chemical binding]; other site 320388004250 putative homodimer interface [polypeptide binding]; other site 320388004251 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004253 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004254 putative chaperone; Provisional; Region: PRK11678 320388004255 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 320388004256 nucleotide binding site [chemical binding]; other site 320388004257 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320388004258 SBD interface [polypeptide binding]; other site 320388004259 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 320388004260 putative FMN binding site [chemical binding]; other site 320388004261 D-galactonate transporter; Region: 2A0114; TIGR00893 320388004262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004263 putative substrate translocation pore; other site 320388004264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388004265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388004266 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 320388004267 Methyltransferase domain; Region: Methyltransf_32; pfam13679 320388004268 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388004269 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 320388004270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388004271 S-adenosylmethionine binding site [chemical binding]; other site 320388004272 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320388004273 Water Stress and Hypersensitive response; Region: WHy; smart00769 320388004274 Peptidase family M1; Region: Peptidase_M1; pfam01433 320388004275 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320388004276 Zn binding site [ion binding]; other site 320388004277 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 320388004278 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388004279 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388004280 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 320388004281 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 320388004282 putative active site [active] 320388004283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320388004284 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 320388004285 Walker A/P-loop; other site 320388004286 ATP binding site [chemical binding]; other site 320388004287 Q-loop/lid; other site 320388004288 ABC transporter signature motif; other site 320388004289 Walker B; other site 320388004290 D-loop; other site 320388004291 H-loop/switch region; other site 320388004292 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 320388004293 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 320388004294 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 320388004295 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 320388004296 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388004297 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320388004298 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320388004299 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 320388004300 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320388004301 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388004302 ligand binding site [chemical binding]; other site 320388004303 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320388004304 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320388004305 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320388004306 Clp amino terminal domain; Region: Clp_N; pfam02861 320388004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388004308 Walker A motif; other site 320388004309 ATP binding site [chemical binding]; other site 320388004310 Walker B motif; other site 320388004311 arginine finger; other site 320388004312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388004313 Walker A motif; other site 320388004314 ATP binding site [chemical binding]; other site 320388004315 Walker B motif; other site 320388004316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320388004317 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320388004318 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388004319 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320388004320 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 320388004321 HTH-like domain; Region: HTH_21; pfam13276 320388004322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004323 Integrase core domain; Region: rve; pfam00665 320388004324 Integrase core domain; Region: rve_3; pfam13683 320388004325 Transposase; Region: HTH_Tnp_1; pfam01527 320388004326 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 320388004327 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 320388004328 dimer interface [polypeptide binding]; other site 320388004329 ssDNA binding site [nucleotide binding]; other site 320388004330 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320388004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388004332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388004333 putative substrate translocation pore; other site 320388004334 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 320388004335 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320388004336 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320388004337 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 320388004338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320388004339 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 320388004340 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 320388004341 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 320388004342 putative active site [active] 320388004343 putative substrate binding site [chemical binding]; other site 320388004344 putative cosubstrate binding site; other site 320388004345 catalytic site [active] 320388004346 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 320388004347 nudix motif; other site 320388004348 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388004349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388004350 active site 320388004351 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320388004352 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 320388004353 TrkA-N domain; Region: TrkA_N; pfam02254 320388004354 TrkA-C domain; Region: TrkA_C; pfam02080 320388004355 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 320388004356 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 320388004357 putative active site [active] 320388004358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 320388004359 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 320388004360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388004361 active site 320388004362 motif I; other site 320388004363 motif II; other site 320388004364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 320388004365 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 320388004366 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 320388004367 OstA-like protein; Region: OstA; pfam03968 320388004368 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 320388004369 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 320388004370 Walker A/P-loop; other site 320388004371 ATP binding site [chemical binding]; other site 320388004372 Q-loop/lid; other site 320388004373 ABC transporter signature motif; other site 320388004374 Walker B; other site 320388004375 D-loop; other site 320388004376 H-loop/switch region; other site 320388004377 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 320388004378 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 320388004379 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 320388004380 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 320388004381 30S subunit binding site; other site 320388004382 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 320388004383 active site 320388004384 phosphorylation site [posttranslational modification] 320388004385 HPr kinase/phosphorylase; Provisional; Region: PRK05428 320388004386 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 320388004387 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 320388004388 Hpr binding site; other site 320388004389 active site 320388004390 homohexamer subunit interaction site [polypeptide binding]; other site 320388004391 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 320388004392 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 320388004393 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 320388004394 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320388004395 minor groove reading motif; other site 320388004396 helix-hairpin-helix signature motif; other site 320388004397 active site 320388004398 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 320388004399 DNA binding and oxoG recognition site [nucleotide binding] 320388004400 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 320388004401 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 320388004402 DNA binding site [nucleotide binding] 320388004403 catalytic residue [active] 320388004404 H2TH interface [polypeptide binding]; other site 320388004405 putative catalytic residues [active] 320388004406 turnover-facilitating residue; other site 320388004407 intercalation triad [nucleotide binding]; other site 320388004408 8OG recognition residue [nucleotide binding]; other site 320388004409 putative reading head residues; other site 320388004410 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 320388004411 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320388004412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320388004413 binding surface 320388004414 TPR motif; other site 320388004415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388004416 binding surface 320388004417 TPR motif; other site 320388004418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388004419 binding surface 320388004420 TPR motif; other site 320388004421 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 320388004422 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 320388004423 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 320388004424 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 320388004425 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 320388004426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388004427 active site 320388004428 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 320388004429 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 320388004430 5S rRNA interface [nucleotide binding]; other site 320388004431 CTC domain interface [polypeptide binding]; other site 320388004432 L16 interface [polypeptide binding]; other site 320388004433 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 320388004434 putative active site [active] 320388004435 catalytic residue [active] 320388004436 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 320388004437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388004439 homodimer interface [polypeptide binding]; other site 320388004440 catalytic residue [active] 320388004441 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 320388004442 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 320388004443 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 320388004444 active site 320388004445 (T/H)XGH motif; other site 320388004446 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 320388004447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388004448 S-adenosylmethionine binding site [chemical binding]; other site 320388004449 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 320388004450 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 320388004451 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320388004452 P loop; other site 320388004453 GTP binding site [chemical binding]; other site 320388004454 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 320388004455 maleylacetoacetate isomerase; Region: maiA; TIGR01262 320388004456 C-terminal domain interface [polypeptide binding]; other site 320388004457 GSH binding site (G-site) [chemical binding]; other site 320388004458 putative dimer interface [polypeptide binding]; other site 320388004459 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 320388004460 dimer interface [polypeptide binding]; other site 320388004461 N-terminal domain interface [polypeptide binding]; other site 320388004462 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 320388004463 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 320388004464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388004465 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320388004466 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320388004467 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388004468 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 320388004469 [2Fe-2S] cluster binding site [ion binding]; other site 320388004470 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926 320388004471 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 320388004472 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 320388004473 molybdopterin cofactor binding site; other site 320388004474 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 320388004475 molybdopterin cofactor binding site; other site 320388004476 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320388004477 glycosyl transferase family protein; Provisional; Region: PRK08136 320388004478 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320388004479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388004480 Coenzyme A binding pocket [chemical binding]; other site 320388004481 2-isopropylmalate synthase; Validated; Region: PRK03739 320388004482 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 320388004483 active site 320388004484 catalytic residues [active] 320388004485 metal binding site [ion binding]; metal-binding site 320388004486 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 320388004487 SnoaL-like domain; Region: SnoaL_3; pfam13474 320388004488 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 320388004489 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 320388004490 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320388004491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388004492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388004493 DNA binding residues [nucleotide binding] 320388004494 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004496 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004497 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 320388004498 zinc binding site [ion binding]; other site 320388004499 putative ligand binding site [chemical binding]; other site 320388004500 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388004501 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 320388004502 TM-ABC transporter signature motif; other site 320388004503 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 320388004504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388004505 Walker A/P-loop; other site 320388004506 ATP binding site [chemical binding]; other site 320388004507 Q-loop/lid; other site 320388004508 ABC transporter signature motif; other site 320388004509 Walker B; other site 320388004510 D-loop; other site 320388004511 H-loop/switch region; other site 320388004512 DNA Polymerase Y-family; Region: PolY_like; cd03468 320388004513 active site 320388004514 DNA binding site [nucleotide binding] 320388004515 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 320388004516 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 320388004517 putative active site [active] 320388004518 putative PHP Thumb interface [polypeptide binding]; other site 320388004519 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 320388004520 generic binding surface II; other site 320388004521 generic binding surface I; other site 320388004522 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320388004523 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320388004524 putative di-iron ligands [ion binding]; other site 320388004525 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320388004526 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 320388004527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388004528 inhibitor-cofactor binding pocket; inhibition site 320388004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388004530 catalytic residue [active] 320388004531 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320388004532 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320388004533 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 320388004534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388004535 Walker A/P-loop; other site 320388004536 ATP binding site [chemical binding]; other site 320388004537 Q-loop/lid; other site 320388004538 ABC transporter signature motif; other site 320388004539 Walker B; other site 320388004540 D-loop; other site 320388004541 H-loop/switch region; other site 320388004542 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320388004543 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388004544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388004545 S-adenosylmethionine binding site [chemical binding]; other site 320388004546 Citrate synthase; Region: Citrate_synt; pfam00285 320388004547 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320388004548 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320388004549 citrylCoA binding site [chemical binding]; other site 320388004550 oxalacetate binding site [chemical binding]; other site 320388004551 coenzyme A binding site [chemical binding]; other site 320388004552 catalytic triad [active] 320388004553 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320388004554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388004555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388004556 active site 320388004557 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320388004558 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320388004559 active site 320388004560 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320388004561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388004562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388004563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388004564 acyl-activating enzyme (AAE) consensus motif; other site 320388004565 acyl-activating enzyme (AAE) consensus motif; other site 320388004566 AMP binding site [chemical binding]; other site 320388004567 active site 320388004568 CoA binding site [chemical binding]; other site 320388004569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 320388004570 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 320388004571 dimer interface [polypeptide binding]; other site 320388004572 active site 320388004573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388004574 catalytic residues [active] 320388004575 substrate binding site [chemical binding]; other site 320388004576 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320388004577 active site 320388004578 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320388004579 dinuclear metal binding motif [ion binding]; other site 320388004580 Phosphopantetheine attachment site; Region: PP-binding; cl09936 320388004581 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320388004582 acyl-CoA synthetase; Validated; Region: PRK09192 320388004583 acyl-activating enzyme (AAE) consensus motif; other site 320388004584 active site 320388004585 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320388004586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388004587 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320388004588 dimerization interface [polypeptide binding]; other site 320388004589 substrate binding pocket [chemical binding]; other site 320388004590 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320388004591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388004592 DNA-binding site [nucleotide binding]; DNA binding site 320388004593 UTRA domain; Region: UTRA; pfam07702 320388004594 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 320388004595 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 320388004596 active site 320388004597 dimer interface [polypeptide binding]; other site 320388004598 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 320388004599 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320388004600 dimer interface [polypeptide binding]; other site 320388004601 active site 320388004602 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320388004603 dimer interface [polypeptide binding]; other site 320388004604 active site 320388004605 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 320388004606 HPr interaction site; other site 320388004607 glycerol kinase (GK) interaction site [polypeptide binding]; other site 320388004608 active site 320388004609 phosphorylation site [posttranslational modification] 320388004610 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 320388004611 dimerization domain swap beta strand [polypeptide binding]; other site 320388004612 regulatory protein interface [polypeptide binding]; other site 320388004613 active site 320388004614 regulatory phosphorylation site [posttranslational modification]; other site 320388004615 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 320388004616 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 320388004617 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320388004618 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320388004619 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 320388004620 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 320388004621 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 320388004622 active site turn [active] 320388004623 phosphorylation site [posttranslational modification] 320388004624 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 320388004625 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 320388004626 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 320388004627 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 320388004628 active site 320388004629 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 320388004630 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 320388004631 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 320388004632 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 320388004633 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 320388004634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388004635 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388004636 HTH-like domain; Region: HTH_21; pfam13276 320388004637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388004638 Integrase core domain; Region: rve; pfam00665 320388004639 Integrase core domain; Region: rve_3; pfam13683 320388004640 Transposase; Region: HTH_Tnp_1; pfam01527 320388004641 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004642 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004643 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320388004644 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 320388004645 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 320388004646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 320388004647 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388004648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388004649 dimer interface [polypeptide binding]; other site 320388004650 putative CheW interface [polypeptide binding]; other site 320388004651 YCII-related domain; Region: YCII; cl00999 320388004652 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320388004653 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320388004654 Cu(I) binding site [ion binding]; other site 320388004655 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 320388004656 UbiA prenyltransferase family; Region: UbiA; pfam01040 320388004657 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 320388004658 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 320388004659 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 320388004660 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 320388004661 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 320388004662 Subunit III/VIIa interface [polypeptide binding]; other site 320388004663 Phospholipid binding site [chemical binding]; other site 320388004664 Subunit I/III interface [polypeptide binding]; other site 320388004665 Subunit III/VIb interface [polypeptide binding]; other site 320388004666 Subunit III/VIa interface; other site 320388004667 Subunit III/Vb interface [polypeptide binding]; other site 320388004668 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 320388004669 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 320388004670 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320388004671 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 320388004672 Subunit I/III interface [polypeptide binding]; other site 320388004673 D-pathway; other site 320388004674 Subunit I/VIIc interface [polypeptide binding]; other site 320388004675 Subunit I/IV interface [polypeptide binding]; other site 320388004676 Subunit I/II interface [polypeptide binding]; other site 320388004677 Low-spin heme (heme a) binding site [chemical binding]; other site 320388004678 Subunit I/VIIa interface [polypeptide binding]; other site 320388004679 Subunit I/VIa interface [polypeptide binding]; other site 320388004680 Dimer interface; other site 320388004681 Putative water exit pathway; other site 320388004682 Binuclear center (heme a3/CuB) [ion binding]; other site 320388004683 K-pathway; other site 320388004684 Subunit I/Vb interface [polypeptide binding]; other site 320388004685 Putative proton exit pathway; other site 320388004686 Subunit I/VIb interface; other site 320388004687 Subunit I/VIc interface [polypeptide binding]; other site 320388004688 Electron transfer pathway; other site 320388004689 Subunit I/VIIIb interface [polypeptide binding]; other site 320388004690 Subunit I/VIIb interface [polypeptide binding]; other site 320388004691 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 320388004692 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 320388004693 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320388004694 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388004695 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 320388004696 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320388004697 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388004698 ligand binding site [chemical binding]; other site 320388004699 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 320388004700 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 320388004701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388004702 S-adenosylmethionine binding site [chemical binding]; other site 320388004703 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 320388004704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388004705 active site 320388004706 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 320388004707 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 320388004708 putative ADP-ribose binding site [chemical binding]; other site 320388004709 putative active site [active] 320388004710 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 320388004711 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 320388004712 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 320388004713 preprotein translocase subunit SecB; Validated; Region: PRK05751 320388004714 SecA binding site; other site 320388004715 Preprotein binding site; other site 320388004716 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 320388004717 GSH binding site [chemical binding]; other site 320388004718 catalytic residues [active] 320388004719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 320388004720 active site residue [active] 320388004721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388004722 catalytic core [active] 320388004723 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388004724 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 320388004725 C-terminal peptidase (prc); Region: prc; TIGR00225 320388004726 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 320388004727 protein binding site [polypeptide binding]; other site 320388004728 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 320388004729 Catalytic dyad [active] 320388004730 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 320388004731 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 320388004732 ATP binding site [chemical binding]; other site 320388004733 substrate interface [chemical binding]; other site 320388004734 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 320388004735 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 320388004736 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320388004737 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320388004738 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 320388004739 dimerization domain swap beta strand [polypeptide binding]; other site 320388004740 regulatory protein interface [polypeptide binding]; other site 320388004741 active site 320388004742 regulatory phosphorylation site [posttranslational modification]; other site 320388004743 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 320388004744 active pocket/dimerization site; other site 320388004745 active site 320388004746 phosphorylation site [posttranslational modification] 320388004747 glutathione synthetase; Provisional; Region: PRK05246 320388004748 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 320388004749 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 320388004750 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 320388004751 Glutamate-cysteine ligase; Region: GshA; pfam08886 320388004752 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004753 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004754 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004755 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 320388004756 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 320388004757 Nitrogen regulatory protein P-II; Region: P-II; smart00938 320388004758 Membrane fusogenic activity; Region: BMFP; pfam04380 320388004759 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 320388004760 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320388004761 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 320388004762 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 320388004763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 320388004764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388004765 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320388004766 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320388004767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388004768 catalytic residues [active] 320388004769 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388004770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388004771 active site 320388004772 phosphorylation site [posttranslational modification] 320388004773 intermolecular recognition site; other site 320388004774 dimerization interface [polypeptide binding]; other site 320388004775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388004776 Walker A motif; other site 320388004777 ATP binding site [chemical binding]; other site 320388004778 Walker B motif; other site 320388004779 arginine finger; other site 320388004780 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388004781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388004782 ATP binding site [chemical binding]; other site 320388004783 Mg2+ binding site [ion binding]; other site 320388004784 G-X-G motif; other site 320388004785 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 320388004786 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 320388004787 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320388004788 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 320388004789 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 320388004790 Na binding site [ion binding]; other site 320388004791 Protein of unknown function, DUF485; Region: DUF485; pfam04341 320388004792 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388004793 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388004794 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 320388004795 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 320388004796 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320388004797 active site 320388004798 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 320388004799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388004800 active site 320388004801 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320388004802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388004803 substrate binding site [chemical binding]; other site 320388004804 oxyanion hole (OAH) forming residues; other site 320388004805 trimer interface [polypeptide binding]; other site 320388004806 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388004807 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388004808 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388004809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388004810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388004811 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388004812 putative effector binding pocket; other site 320388004813 dimerization interface [polypeptide binding]; other site 320388004814 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320388004815 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320388004816 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320388004817 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004819 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004820 lipoyl synthase; Provisional; Region: PRK05481 320388004821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388004822 FeS/SAM binding site; other site 320388004823 lipoate-protein ligase B; Provisional; Region: PRK14343 320388004824 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 320388004825 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388004826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388004827 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320388004828 dimerization interface [polypeptide binding]; other site 320388004829 substrate binding pocket [chemical binding]; other site 320388004830 hypothetical protein; Provisional; Region: PRK02047 320388004831 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 320388004832 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320388004833 homodimer interface [polypeptide binding]; other site 320388004834 substrate-cofactor binding pocket; other site 320388004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388004836 catalytic residue [active] 320388004837 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 320388004838 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320388004839 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 320388004840 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 320388004841 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 320388004842 dimer interface [polypeptide binding]; other site 320388004843 [2Fe-2S] cluster binding site [ion binding]; other site 320388004844 Protein of unknown function (DUF330); Region: DUF330; pfam03886 320388004845 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 320388004846 mce related protein; Region: MCE; pfam02470 320388004847 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320388004848 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 320388004849 Walker A/P-loop; other site 320388004850 ATP binding site [chemical binding]; other site 320388004851 Q-loop/lid; other site 320388004852 ABC transporter signature motif; other site 320388004853 Walker B; other site 320388004854 D-loop; other site 320388004855 H-loop/switch region; other site 320388004856 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 320388004857 Permease; Region: Permease; pfam02405 320388004858 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 320388004859 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 320388004860 active site 320388004861 metal binding site [ion binding]; metal-binding site 320388004862 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 320388004863 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 320388004864 Sel1-like repeats; Region: SEL1; smart00671 320388004865 Sel1-like repeats; Region: SEL1; smart00671 320388004866 biotin--protein ligase; Provisional; Region: PRK06955 320388004867 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 320388004868 pantothenate kinase; Reviewed; Region: PRK13328 320388004869 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 320388004870 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 320388004871 active site 320388004872 HIGH motif; other site 320388004873 nucleotide binding site [chemical binding]; other site 320388004874 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 320388004875 dinuclear metal binding motif [ion binding]; other site 320388004876 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320388004877 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320388004878 active site 320388004879 nucleophile elbow; other site 320388004880 enoyl-CoA hydratase; Provisional; Region: PRK07657 320388004881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388004882 substrate binding site [chemical binding]; other site 320388004883 oxyanion hole (OAH) forming residues; other site 320388004884 trimer interface [polypeptide binding]; other site 320388004885 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320388004886 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320388004887 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320388004888 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388004889 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388004890 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388004891 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 320388004892 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 320388004893 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 320388004894 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 320388004895 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 320388004896 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 320388004897 substrate binding pocket [chemical binding]; other site 320388004898 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 320388004899 B12 binding site [chemical binding]; other site 320388004900 cobalt ligand [ion binding]; other site 320388004901 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 320388004902 Transposase domain (DUF772); Region: DUF772; pfam05598 320388004903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388004904 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388004905 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 320388004906 23S rRNA interface [nucleotide binding]; other site 320388004907 L3 interface [polypeptide binding]; other site 320388004908 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 320388004909 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 320388004910 Cupin; Region: Cupin_6; pfam12852 320388004911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388004912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388004913 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320388004914 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320388004915 C-terminal domain interface [polypeptide binding]; other site 320388004916 GSH binding site (G-site) [chemical binding]; other site 320388004917 dimer interface [polypeptide binding]; other site 320388004918 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 320388004919 N-terminal domain interface [polypeptide binding]; other site 320388004920 dimer interface [polypeptide binding]; other site 320388004921 substrate binding pocket (H-site) [chemical binding]; other site 320388004922 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320388004923 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320388004924 C-terminal domain interface [polypeptide binding]; other site 320388004925 GSH binding site (G-site) [chemical binding]; other site 320388004926 dimer interface [polypeptide binding]; other site 320388004927 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 320388004928 N-terminal domain interface [polypeptide binding]; other site 320388004929 putative dimer interface [polypeptide binding]; other site 320388004930 active site 320388004931 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 320388004932 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 320388004933 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 320388004934 active site 320388004935 HIGH motif; other site 320388004936 dimer interface [polypeptide binding]; other site 320388004937 KMSKS motif; other site 320388004938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388004939 RNA binding surface [nucleotide binding]; other site 320388004940 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 320388004941 putative active site [active] 320388004942 dimerization interface [polypeptide binding]; other site 320388004943 putative tRNAtyr binding site [nucleotide binding]; other site 320388004944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388004945 catalytic core [active] 320388004946 Putative ParB-like nuclease; Region: ParBc_2; cl17538 320388004947 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 320388004948 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 320388004949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388004950 Walker A motif; other site 320388004951 ATP binding site [chemical binding]; other site 320388004952 Walker B motif; other site 320388004953 arginine finger; other site 320388004954 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 320388004955 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 320388004956 RuvA N terminal domain; Region: RuvA_N; pfam01330 320388004957 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 320388004958 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 320388004959 active site 320388004960 putative DNA-binding cleft [nucleotide binding]; other site 320388004961 dimer interface [polypeptide binding]; other site 320388004962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 320388004963 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 320388004964 purine monophosphate binding site [chemical binding]; other site 320388004965 dimer interface [polypeptide binding]; other site 320388004966 putative catalytic residues [active] 320388004967 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 320388004968 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 320388004969 DNA-binding protein Fis; Provisional; Region: PRK01905 320388004970 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 320388004971 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 320388004972 FMN binding site [chemical binding]; other site 320388004973 active site 320388004974 catalytic residues [active] 320388004975 substrate binding site [chemical binding]; other site 320388004976 hypothetical protein; Provisional; Region: PRK06996 320388004977 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320388004978 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 320388004979 proline aminopeptidase P II; Provisional; Region: PRK10879 320388004980 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 320388004981 active site 320388004982 putative glutathione S-transferase; Provisional; Region: PRK10357 320388004983 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 320388004984 putative C-terminal domain interface [polypeptide binding]; other site 320388004985 putative GSH binding site (G-site) [chemical binding]; other site 320388004986 putative dimer interface [polypeptide binding]; other site 320388004987 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 320388004988 dimer interface [polypeptide binding]; other site 320388004989 N-terminal domain interface [polypeptide binding]; other site 320388004990 putative substrate binding pocket (H-site) [chemical binding]; other site 320388004991 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 320388004992 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 320388004993 active site 320388004994 FMN binding site [chemical binding]; other site 320388004995 substrate binding site [chemical binding]; other site 320388004996 3Fe-4S cluster binding site [ion binding]; other site 320388004997 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 320388004998 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 320388004999 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 320388005000 nudix motif; other site 320388005001 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 320388005002 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 320388005003 ligand binding site [chemical binding]; other site 320388005004 homodimer interface [polypeptide binding]; other site 320388005005 NAD(P) binding site [chemical binding]; other site 320388005006 trimer interface B [polypeptide binding]; other site 320388005007 trimer interface A [polypeptide binding]; other site 320388005008 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 320388005009 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 320388005010 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 320388005011 Predicted transcriptional regulator [Transcription]; Region: COG2378 320388005012 HTH domain; Region: HTH_11; pfam08279 320388005013 WYL domain; Region: WYL; pfam13280 320388005014 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 320388005015 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 320388005016 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 320388005017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388005018 Site-specific recombinase; Region: SpecificRecomb; pfam10136 320388005019 Protein of unknown function (DUF330); Region: DUF330; pfam03886 320388005020 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 320388005021 mce related protein; Region: MCE; pfam02470 320388005022 mce related protein; Region: MCE; pfam02470 320388005023 Paraquat-inducible protein A; Region: PqiA; pfam04403 320388005024 Paraquat-inducible protein A; Region: PqiA; pfam04403 320388005025 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320388005026 YceI-like domain; Region: YceI; smart00867 320388005027 Uncharacterized conserved protein [Function unknown]; Region: COG2353 320388005028 citrate-proton symporter; Provisional; Region: PRK15075 320388005029 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 320388005030 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 320388005031 Protein export membrane protein; Region: SecD_SecF; pfam02355 320388005032 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 320388005033 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 320388005034 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 320388005035 Protein export membrane protein; Region: SecD_SecF; cl14618 320388005036 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 320388005037 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 320388005038 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 320388005039 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 320388005040 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 320388005041 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 320388005042 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 320388005043 generic binding surface II; other site 320388005044 ssDNA binding site; other site 320388005045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388005046 ATP binding site [chemical binding]; other site 320388005047 putative Mg++ binding site [ion binding]; other site 320388005048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388005049 nucleotide binding region [chemical binding]; other site 320388005050 ATP-binding site [chemical binding]; other site 320388005051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388005052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388005053 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 320388005054 dimerization interface [polypeptide binding]; other site 320388005055 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 320388005056 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 320388005057 dimer interface [polypeptide binding]; other site 320388005058 active site 320388005059 heme binding site [chemical binding]; other site 320388005060 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 320388005061 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 320388005062 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 320388005063 dimerization interface [polypeptide binding]; other site 320388005064 DPS ferroxidase diiron center [ion binding]; other site 320388005065 ion pore; other site 320388005066 Predicted transcriptional regulators [Transcription]; Region: COG1733 320388005067 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320388005068 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 320388005069 UbiA prenyltransferase family; Region: UbiA; pfam01040 320388005070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 320388005071 active site 320388005072 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 320388005073 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 320388005074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388005075 DNA-binding site [nucleotide binding]; DNA binding site 320388005076 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 320388005077 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 320388005078 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 320388005079 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 320388005080 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 320388005081 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 320388005082 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388005083 Walker A/P-loop; other site 320388005084 ATP binding site [chemical binding]; other site 320388005085 Q-loop/lid; other site 320388005086 ABC transporter signature motif; other site 320388005087 Walker B; other site 320388005088 D-loop; other site 320388005089 H-loop/switch region; other site 320388005090 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388005091 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 320388005092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388005093 Walker A/P-loop; other site 320388005094 ATP binding site [chemical binding]; other site 320388005095 Q-loop/lid; other site 320388005096 ABC transporter signature motif; other site 320388005097 Walker B; other site 320388005098 D-loop; other site 320388005099 H-loop/switch region; other site 320388005100 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 320388005101 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388005102 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 320388005103 active site 320388005104 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 320388005105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388005106 Walker A/P-loop; other site 320388005107 ATP binding site [chemical binding]; other site 320388005108 Q-loop/lid; other site 320388005109 ABC transporter signature motif; other site 320388005110 Walker B; other site 320388005111 D-loop; other site 320388005112 H-loop/switch region; other site 320388005113 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 320388005114 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 320388005115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388005116 dimer interface [polypeptide binding]; other site 320388005117 conserved gate region; other site 320388005118 ABC-ATPase subunit interface; other site 320388005119 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 320388005120 pyrroline-5-carboxylate reductase; Region: PLN02688 320388005121 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 320388005122 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388005123 catalytic residue [active] 320388005124 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 320388005125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 320388005126 Cysteine-rich domain; Region: CCG; pfam02754 320388005127 Cysteine-rich domain; Region: CCG; pfam02754 320388005128 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 320388005129 FAD binding domain; Region: FAD_binding_4; pfam01565 320388005130 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 320388005131 FAD binding domain; Region: FAD_binding_4; pfam01565 320388005132 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388005133 FAD binding domain; Region: FAD_binding_4; pfam01565 320388005134 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 320388005135 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 320388005136 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 320388005137 heme-binding site [chemical binding]; other site 320388005138 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 320388005139 FAD binding pocket [chemical binding]; other site 320388005140 FAD binding motif [chemical binding]; other site 320388005141 phosphate binding motif [ion binding]; other site 320388005142 beta-alpha-beta structure motif; other site 320388005143 NAD binding pocket [chemical binding]; other site 320388005144 Heme binding pocket [chemical binding]; other site 320388005145 Transposase domain (DUF772); Region: DUF772; pfam05598 320388005146 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388005147 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388005148 OsmC-like protein; Region: OsmC; cl00767 320388005149 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 320388005150 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 320388005151 active site 320388005152 substrate binding pocket [chemical binding]; other site 320388005153 dimer interface [polypeptide binding]; other site 320388005154 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 320388005155 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 320388005156 putative active site [active] 320388005157 putative dimer interface [polypeptide binding]; other site 320388005158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320388005159 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320388005160 putative dimer interface [polypeptide binding]; other site 320388005161 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320388005162 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320388005163 putative dimer interface [polypeptide binding]; other site 320388005164 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320388005165 oligomerisation interface [polypeptide binding]; other site 320388005166 mobile loop; other site 320388005167 roof hairpin; other site 320388005168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320388005169 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388005170 Walker A/P-loop; other site 320388005171 ATP binding site [chemical binding]; other site 320388005172 Q-loop/lid; other site 320388005173 ABC transporter signature motif; other site 320388005174 Walker B; other site 320388005175 D-loop; other site 320388005176 H-loop/switch region; other site 320388005177 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388005178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388005179 dimer interface [polypeptide binding]; other site 320388005180 conserved gate region; other site 320388005181 putative PBP binding loops; other site 320388005182 ABC-ATPase subunit interface; other site 320388005183 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388005184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388005185 dimer interface [polypeptide binding]; other site 320388005186 conserved gate region; other site 320388005187 putative PBP binding loops; other site 320388005188 ABC-ATPase subunit interface; other site 320388005189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388005190 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388005191 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 320388005192 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 320388005193 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 320388005194 NAD(P) binding site [chemical binding]; other site 320388005195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388005196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388005197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388005198 dimerization interface [polypeptide binding]; other site 320388005199 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 320388005200 adenylosuccinate lyase; Provisional; Region: PRK09285 320388005201 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 320388005202 tetramer interface [polypeptide binding]; other site 320388005203 active site 320388005204 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 320388005205 ATP-binding site [chemical binding]; other site 320388005206 Gluconate-6-phosphate binding site [chemical binding]; other site 320388005207 Shikimate kinase; Region: SKI; pfam01202 320388005208 GntP family permease; Region: GntP_permease; pfam02447 320388005209 fructuronate transporter; Provisional; Region: PRK10034; cl15264 320388005210 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 320388005211 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 320388005212 active site 320388005213 intersubunit interface [polypeptide binding]; other site 320388005214 catalytic residue [active] 320388005215 phosphogluconate dehydratase; Validated; Region: PRK09054 320388005216 6-phosphogluconate dehydratase; Region: edd; TIGR01196 320388005217 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388005218 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388005219 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320388005220 putative active site [active] 320388005221 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 320388005222 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 320388005223 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 320388005224 putative catalytic cysteine [active] 320388005225 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 320388005226 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 320388005227 Lipopolysaccharide-assembly; Region: LptE; cl01125 320388005228 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 320388005229 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 320388005230 HIGH motif; other site 320388005231 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320388005232 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388005233 active site 320388005234 KMSKS motif; other site 320388005235 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 320388005236 tRNA binding surface [nucleotide binding]; other site 320388005237 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320388005238 TolR protein; Region: tolR; TIGR02801 320388005239 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320388005240 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 320388005241 dihydrodipicolinate reductase; Provisional; Region: PRK00048 320388005242 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 320388005243 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 320388005244 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 320388005245 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 320388005246 ferric uptake regulator; Provisional; Region: fur; PRK09462 320388005247 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 320388005248 metal binding site 2 [ion binding]; metal-binding site 320388005249 putative DNA binding helix; other site 320388005250 metal binding site 1 [ion binding]; metal-binding site 320388005251 dimer interface [polypeptide binding]; other site 320388005252 structural Zn2+ binding site [ion binding]; other site 320388005253 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 320388005254 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 320388005255 allantoicase; Provisional; Region: PRK13257 320388005256 Allantoicase repeat; Region: Allantoicase; pfam03561 320388005257 Allantoicase repeat; Region: Allantoicase; pfam03561 320388005258 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 320388005259 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320388005260 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320388005261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388005262 DNA-binding site [nucleotide binding]; DNA binding site 320388005263 FCD domain; Region: FCD; pfam07729 320388005264 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 320388005265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388005266 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 320388005267 dimerization interface [polypeptide binding]; other site 320388005268 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 320388005269 active site clefts [active] 320388005270 zinc binding site [ion binding]; other site 320388005271 dimer interface [polypeptide binding]; other site 320388005272 cyanate hydratase; Validated; Region: PRK02866 320388005273 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 320388005274 oligomer interface [polypeptide binding]; other site 320388005275 active site 320388005276 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320388005277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388005278 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 320388005279 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 320388005280 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 320388005281 transketolase; Reviewed; Region: PRK12753 320388005282 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 320388005283 TPP-binding site [chemical binding]; other site 320388005284 dimer interface [polypeptide binding]; other site 320388005285 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320388005286 PYR/PP interface [polypeptide binding]; other site 320388005287 dimer interface [polypeptide binding]; other site 320388005288 TPP binding site [chemical binding]; other site 320388005289 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320388005290 spermidine synthase; Provisional; Region: PRK00811 320388005291 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 320388005292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 320388005293 putative dimer interface [polypeptide binding]; other site 320388005294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388005295 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 320388005296 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 320388005297 putative RNAase interaction site [polypeptide binding]; other site 320388005298 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 320388005299 active site 320388005300 barstar interaction site; other site 320388005301 malic enzyme; Reviewed; Region: PRK12862 320388005302 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320388005303 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320388005304 putative NAD(P) binding site [chemical binding]; other site 320388005305 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 320388005306 thiamine monophosphate kinase; Provisional; Region: PRK05731 320388005307 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 320388005308 ATP binding site [chemical binding]; other site 320388005309 dimerization interface [polypeptide binding]; other site 320388005310 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 320388005311 tetramer interfaces [polypeptide binding]; other site 320388005312 binuclear metal-binding site [ion binding]; other site 320388005313 Competence-damaged protein; Region: CinA; pfam02464 320388005314 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 320388005315 active site 320388005316 dimer interface [polypeptide binding]; other site 320388005317 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 320388005318 active site 320388005319 catalytic residues [active] 320388005320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320388005321 classical (c) SDRs; Region: SDR_c; cd05233 320388005322 NAD(P) binding site [chemical binding]; other site 320388005323 active site 320388005324 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388005325 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320388005326 TM-ABC transporter signature motif; other site 320388005327 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 320388005328 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320388005329 Walker A/P-loop; other site 320388005330 ATP binding site [chemical binding]; other site 320388005331 Q-loop/lid; other site 320388005332 ABC transporter signature motif; other site 320388005333 Walker B; other site 320388005334 D-loop; other site 320388005335 H-loop/switch region; other site 320388005336 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320388005337 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 320388005338 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 320388005339 ligand binding site [chemical binding]; other site 320388005340 short chain dehydrogenase; Provisional; Region: PRK07063 320388005341 classical (c) SDRs; Region: SDR_c; cd05233 320388005342 NAD(P) binding site [chemical binding]; other site 320388005343 active site 320388005344 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 320388005345 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 320388005346 active site 320388005347 intersubunit interface [polypeptide binding]; other site 320388005348 catalytic residue [active] 320388005349 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 320388005350 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 320388005351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388005352 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388005353 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388005354 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320388005355 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320388005356 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 320388005357 Transglycosylase; Region: Transgly; cl17702 320388005358 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 320388005359 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 320388005360 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 320388005361 shikimate binding site; other site 320388005362 NAD(P) binding site [chemical binding]; other site 320388005363 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 320388005364 RNB domain; Region: RNB; pfam00773 320388005365 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 320388005366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320388005367 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 320388005368 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320388005369 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388005370 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388005371 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320388005372 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388005373 catalytic residues [active] 320388005374 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 320388005375 Dehydroquinase class II; Region: DHquinase_II; pfam01220 320388005376 active site 320388005377 trimer interface [polypeptide binding]; other site 320388005378 dimer interface [polypeptide binding]; other site 320388005379 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 320388005380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320388005381 carboxyltransferase (CT) interaction site; other site 320388005382 biotinylation site [posttranslational modification]; other site 320388005383 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 320388005384 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320388005385 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388005386 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320388005387 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 320388005388 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320388005389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388005390 S-adenosylmethionine binding site [chemical binding]; other site 320388005391 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 320388005392 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 320388005393 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 320388005394 dimer interface [polypeptide binding]; other site 320388005395 catalytic triad [active] 320388005396 peroxidatic and resolving cysteines [active] 320388005397 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388005398 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 320388005399 substrate binding site [chemical binding]; other site 320388005400 ATP binding site [chemical binding]; other site 320388005401 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 320388005402 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 320388005403 dimer interface [polypeptide binding]; other site 320388005404 putative radical transfer pathway; other site 320388005405 diiron center [ion binding]; other site 320388005406 tyrosyl radical; other site 320388005407 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 320388005408 ATP cone domain; Region: ATP-cone; pfam03477 320388005409 Class I ribonucleotide reductase; Region: RNR_I; cd01679 320388005410 active site 320388005411 dimer interface [polypeptide binding]; other site 320388005412 catalytic residues [active] 320388005413 effector binding site; other site 320388005414 R2 peptide binding site; other site 320388005415 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320388005416 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320388005417 amidase catalytic site [active] 320388005418 Zn binding residues [ion binding]; other site 320388005419 substrate binding site [chemical binding]; other site 320388005420 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 320388005421 signal recognition particle protein; Provisional; Region: PRK10867 320388005422 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 320388005423 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320388005424 P loop; other site 320388005425 GTP binding site [chemical binding]; other site 320388005426 Signal peptide binding domain; Region: SRP_SPB; pfam02978 320388005427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388005428 active site 320388005429 MarC family integral membrane protein; Region: MarC; cl00919 320388005430 prolyl-tRNA synthetase; Provisional; Region: PRK09194 320388005431 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 320388005432 dimer interface [polypeptide binding]; other site 320388005433 motif 1; other site 320388005434 active site 320388005435 motif 2; other site 320388005436 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 320388005437 putative deacylase active site [active] 320388005438 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 320388005439 active site 320388005440 motif 3; other site 320388005441 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 320388005442 anticodon binding site; other site 320388005443 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 320388005444 putative active site [active] 320388005445 Ap4A binding site [chemical binding]; other site 320388005446 nudix motif; other site 320388005447 putative metal binding site [ion binding]; other site 320388005448 CNP1-like family; Region: CNP1; pfam08750 320388005449 gamma-glutamyl kinase; Provisional; Region: PRK05429 320388005450 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 320388005451 nucleotide binding site [chemical binding]; other site 320388005452 homotetrameric interface [polypeptide binding]; other site 320388005453 putative phosphate binding site [ion binding]; other site 320388005454 putative allosteric binding site; other site 320388005455 PUA domain; Region: PUA; pfam01472 320388005456 GTPase CgtA; Reviewed; Region: obgE; PRK12298 320388005457 GTP1/OBG; Region: GTP1_OBG; pfam01018 320388005458 Obg GTPase; Region: Obg; cd01898 320388005459 G1 box; other site 320388005460 GTP/Mg2+ binding site [chemical binding]; other site 320388005461 Switch I region; other site 320388005462 G2 box; other site 320388005463 G3 box; other site 320388005464 Switch II region; other site 320388005465 G4 box; other site 320388005466 G5 box; other site 320388005467 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 320388005468 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 320388005469 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 320388005470 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320388005471 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320388005472 substrate binding pocket [chemical binding]; other site 320388005473 chain length determination region; other site 320388005474 substrate-Mg2+ binding site; other site 320388005475 catalytic residues [active] 320388005476 aspartate-rich region 1; other site 320388005477 active site lid residues [active] 320388005478 aspartate-rich region 2; other site 320388005479 HTH-like domain; Region: HTH_21; pfam13276 320388005480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388005481 Integrase core domain; Region: rve; pfam00665 320388005482 Integrase core domain; Region: rve_3; pfam13683 320388005483 Transposase; Region: HTH_Tnp_1; pfam01527 320388005484 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 320388005485 Domain of unknown function DUF21; Region: DUF21; pfam01595 320388005486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320388005487 Transporter associated domain; Region: CorC_HlyC; smart01091 320388005488 Type II/IV secretion system protein; Region: T2SE; pfam00437 320388005489 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 320388005490 Walker A motif; other site 320388005491 ATP binding site [chemical binding]; other site 320388005492 Walker B motif; other site 320388005493 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 320388005494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388005495 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388005496 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 320388005497 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 320388005498 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 320388005499 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 320388005500 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 320388005501 CoA-binding site [chemical binding]; other site 320388005502 ATP-binding [chemical binding]; other site 320388005503 hypothetical protein; Provisional; Region: PRK05287 320388005504 Domain of unknown function (DUF329); Region: DUF329; pfam03884 320388005505 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 320388005506 active site 320388005507 8-oxo-dGMP binding site [chemical binding]; other site 320388005508 nudix motif; other site 320388005509 metal binding site [ion binding]; metal-binding site 320388005510 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 320388005511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388005512 Walker A motif; other site 320388005513 ATP binding site [chemical binding]; other site 320388005514 Walker B motif; other site 320388005515 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 320388005516 heterotetramer interface [polypeptide binding]; other site 320388005517 active site pocket [active] 320388005518 cleavage site 320388005519 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 320388005520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 320388005521 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 320388005522 SEC-C motif; Region: SEC-C; pfam02810 320388005523 Protein of unknown function (DUF721); Region: DUF721; pfam05258 320388005524 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 320388005525 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 320388005526 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 320388005527 catalytic triad [active] 320388005528 dimer interface [polypeptide binding]; other site 320388005529 cell division protein FtsZ; Validated; Region: PRK09330 320388005530 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 320388005531 nucleotide binding site [chemical binding]; other site 320388005532 SulA interaction site; other site 320388005533 cell division protein FtsA; Region: ftsA; TIGR01174 320388005534 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 320388005535 nucleotide binding site [chemical binding]; other site 320388005536 Cell division protein FtsA; Region: FtsA; pfam14450 320388005537 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 320388005538 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 320388005539 Cell division protein FtsQ; Region: FtsQ; pfam03799 320388005540 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 320388005541 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 320388005542 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388005543 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 320388005544 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320388005545 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388005546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388005547 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 320388005548 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 320388005549 active site 320388005550 homodimer interface [polypeptide binding]; other site 320388005551 cell division protein FtsW; Region: ftsW; TIGR02614 320388005552 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 320388005553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388005554 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388005555 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 320388005556 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 320388005557 Mg++ binding site [ion binding]; other site 320388005558 putative catalytic motif [active] 320388005559 putative substrate binding site [chemical binding]; other site 320388005560 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 320388005561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320388005562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388005563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388005564 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 320388005565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320388005566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320388005567 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320388005568 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320388005569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320388005570 Cell division protein FtsL; Region: FtsL; pfam04999 320388005571 MraW methylase family; Region: Methyltransf_5; cl17771 320388005572 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 320388005573 cell division protein MraZ; Reviewed; Region: PRK00326 320388005574 MraZ protein; Region: MraZ; pfam02381 320388005575 MraZ protein; Region: MraZ; pfam02381 320388005576 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 320388005577 diiron binding motif [ion binding]; other site 320388005578 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388005579 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388005580 trimer interface [polypeptide binding]; other site 320388005581 eyelet of channel; other site 320388005582 Transposase domain (DUF772); Region: DUF772; pfam05598 320388005583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388005584 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388005585 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 320388005586 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320388005587 protease TldD; Provisional; Region: tldD; PRK10735 320388005588 nitrilase; Region: PLN02798 320388005589 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 320388005590 putative active site [active] 320388005591 catalytic triad [active] 320388005592 dimer interface [polypeptide binding]; other site 320388005593 TIGR02099 family protein; Region: TIGR02099 320388005594 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 320388005595 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 320388005596 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320388005597 metal binding triad; other site 320388005598 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320388005599 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320388005600 metal binding triad; other site 320388005601 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320388005602 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 320388005603 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 320388005604 Walker A/P-loop; other site 320388005605 ATP binding site [chemical binding]; other site 320388005606 Q-loop/lid; other site 320388005607 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 320388005608 ABC transporter signature motif; other site 320388005609 Walker B; other site 320388005610 D-loop; other site 320388005611 H-loop/switch region; other site 320388005612 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 320388005613 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 320388005614 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 320388005615 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 320388005616 ferrochelatase; Reviewed; Region: hemH; PRK00035 320388005617 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 320388005618 C-terminal domain interface [polypeptide binding]; other site 320388005619 active site 320388005620 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 320388005621 active site 320388005622 N-terminal domain interface [polypeptide binding]; other site 320388005623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388005624 RNA binding surface [nucleotide binding]; other site 320388005625 GrpE; Region: GrpE; pfam01025 320388005626 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 320388005627 dimer interface [polypeptide binding]; other site 320388005628 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 320388005629 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320388005630 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 320388005631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320388005632 nucleotide binding site [chemical binding]; other site 320388005633 chaperone protein DnaJ; Provisional; Region: PRK10767 320388005634 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320388005635 HSP70 interaction site [polypeptide binding]; other site 320388005636 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 320388005637 Zn binding sites [ion binding]; other site 320388005638 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 320388005639 dimer interface [polypeptide binding]; other site 320388005640 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 320388005641 chorismate binding enzyme; Region: Chorismate_bind; cl10555 320388005642 hypothetical protein; Provisional; Region: PRK07546 320388005643 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320388005644 homodimer interface [polypeptide binding]; other site 320388005645 substrate-cofactor binding pocket; other site 320388005646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388005647 catalytic residue [active] 320388005648 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 320388005649 oligomerization interface [polypeptide binding]; other site 320388005650 active site 320388005651 metal binding site [ion binding]; metal-binding site 320388005652 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 320388005653 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 320388005654 Substrate-binding site [chemical binding]; other site 320388005655 Substrate specificity [chemical binding]; other site 320388005656 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 320388005657 catalytic center binding site [active] 320388005658 ATP binding site [chemical binding]; other site 320388005659 poly(A) polymerase; Region: pcnB; TIGR01942 320388005660 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 320388005661 active site 320388005662 NTP binding site [chemical binding]; other site 320388005663 metal binding triad [ion binding]; metal-binding site 320388005664 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 320388005665 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 320388005666 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 320388005667 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 320388005668 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 320388005669 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 320388005670 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 320388005671 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 320388005672 dimerization interface [polypeptide binding]; other site 320388005673 putative ATP binding site [chemical binding]; other site 320388005674 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 320388005675 SnoaL-like domain; Region: SnoaL_3; pfam13474 320388005676 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 320388005677 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 320388005678 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 320388005679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388005680 ATP binding site [chemical binding]; other site 320388005681 Mg2+ binding site [ion binding]; other site 320388005682 G-X-G motif; other site 320388005683 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 320388005684 ATP binding site [chemical binding]; other site 320388005685 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 320388005686 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 320388005687 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 320388005688 mechanosensitive channel MscS; Provisional; Region: PRK10334 320388005689 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320388005690 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 320388005691 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 320388005692 putative active site [active] 320388005693 putative dimer interface [polypeptide binding]; other site 320388005694 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 320388005695 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320388005696 Substrate binding site; other site 320388005697 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 320388005698 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 320388005699 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320388005700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388005701 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 320388005702 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320388005703 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 320388005704 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320388005705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388005706 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 320388005707 Q-loop/lid; other site 320388005708 ABC transporter signature motif; other site 320388005709 Walker B; other site 320388005710 D-loop; other site 320388005711 H-loop/switch region; other site 320388005712 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320388005713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388005714 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 320388005715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388005716 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388005717 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 320388005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388005719 active site 320388005720 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 320388005721 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 320388005722 NADP-binding site; other site 320388005723 homotetramer interface [polypeptide binding]; other site 320388005724 substrate binding site [chemical binding]; other site 320388005725 homodimer interface [polypeptide binding]; other site 320388005726 active site 320388005727 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 320388005728 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 320388005729 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388005730 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 320388005731 dimer interface [polypeptide binding]; other site 320388005732 active site 320388005733 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 320388005734 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 320388005735 Substrate binding site; other site 320388005736 Mg++ binding site; other site 320388005737 metal-binding site 320388005738 Mg++ binding site; other site 320388005739 metal-binding site 320388005740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388005741 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 320388005742 active site 320388005743 motif I; other site 320388005744 motif II; other site 320388005745 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 320388005746 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 320388005747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388005748 NAD(P) binding site [chemical binding]; other site 320388005749 active site 320388005750 Sulfatase; Region: Sulfatase; pfam00884 320388005751 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 320388005752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320388005753 active site 320388005754 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320388005755 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320388005756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388005757 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320388005758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388005759 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 320388005760 Enoylreductase; Region: PKS_ER; smart00829 320388005761 NAD(P) binding site [chemical binding]; other site 320388005762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 320388005763 KR domain; Region: KR; pfam08659 320388005764 putative NADP binding site [chemical binding]; other site 320388005765 active site 320388005766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320388005767 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 320388005768 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 320388005769 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320388005770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388005771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388005772 catalytic residue [active] 320388005773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388005774 Transposase; Region: HTH_Tnp_1; pfam01527 320388005775 HTH-like domain; Region: HTH_21; pfam13276 320388005776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388005777 Integrase core domain; Region: rve; pfam00665 320388005778 Integrase core domain; Region: rve_3; pfam13683 320388005779 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 320388005780 elongation factor G; Reviewed; Region: PRK00007 320388005781 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 320388005782 G1 box; other site 320388005783 putative GEF interaction site [polypeptide binding]; other site 320388005784 GTP/Mg2+ binding site [chemical binding]; other site 320388005785 Switch I region; other site 320388005786 G2 box; other site 320388005787 G3 box; other site 320388005788 Switch II region; other site 320388005789 G4 box; other site 320388005790 G5 box; other site 320388005791 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 320388005792 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 320388005793 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 320388005794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320388005795 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320388005796 active site 320388005797 catalytic tetrad [active] 320388005798 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320388005799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388005800 DNA-binding site [nucleotide binding]; DNA binding site 320388005801 UTRA domain; Region: UTRA; pfam07702 320388005802 Helix-turn-helix domain; Region: HTH_17; pfam12728 320388005803 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320388005804 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 320388005805 dimer interface [polypeptide binding]; other site 320388005806 active site 320388005807 oxalacetate/citrate binding site [chemical binding]; other site 320388005808 citrylCoA binding site [chemical binding]; other site 320388005809 coenzyme A binding site [chemical binding]; other site 320388005810 catalytic triad [active] 320388005811 putative transporter; Provisional; Region: PRK10504 320388005812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388005813 putative substrate translocation pore; other site 320388005814 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320388005815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388005816 S-adenosylmethionine binding site [chemical binding]; other site 320388005817 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 320388005818 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320388005819 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320388005820 Protein of unknown function (DUF962); Region: DUF962; cl01879 320388005821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388005822 HTH-like domain; Region: HTH_21; pfam13276 320388005823 Integrase core domain; Region: rve; pfam00665 320388005824 Integrase core domain; Region: rve_3; pfam13683 320388005825 Transposase; Region: HTH_Tnp_1; pfam01527 320388005826 superoxide dismutase; Provisional; Region: PRK10543 320388005827 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 320388005828 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 320388005829 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 320388005830 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 320388005831 generic binding surface II; other site 320388005832 generic binding surface I; other site 320388005833 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 320388005834 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 320388005835 Uncharacterized conserved protein [Function unknown]; Region: COG2835 320388005836 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 320388005837 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 320388005838 Ligand binding site; other site 320388005839 oligomer interface; other site 320388005840 adenylate kinase; Reviewed; Region: adk; PRK00279 320388005841 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 320388005842 AMP-binding site [chemical binding]; other site 320388005843 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 320388005844 Transposase domain (DUF772); Region: DUF772; pfam05598 320388005845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388005846 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388005847 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320388005848 DNA-binding site [nucleotide binding]; DNA binding site 320388005849 RNA-binding motif; other site 320388005850 Uncharacterized conserved protein [Function unknown]; Region: COG2127 320388005851 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 320388005852 Clp amino terminal domain; Region: Clp_N; pfam02861 320388005853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388005854 Walker A motif; other site 320388005855 ATP binding site [chemical binding]; other site 320388005856 Walker B motif; other site 320388005857 arginine finger; other site 320388005858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388005859 Walker A motif; other site 320388005860 ATP binding site [chemical binding]; other site 320388005861 Walker B motif; other site 320388005862 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320388005863 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320388005864 HTH-like domain; Region: HTH_21; pfam13276 320388005865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388005866 Integrase core domain; Region: rve; pfam00665 320388005867 Integrase core domain; Region: rve_3; pfam13683 320388005868 Transposase; Region: HTH_Tnp_1; pfam01527 320388005869 Peptidase family M48; Region: Peptidase_M48; pfam01435 320388005870 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 320388005871 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 320388005872 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 320388005873 SnoaL-like domain; Region: SnoaL_3; pfam13474 320388005874 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388005875 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388005876 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388005877 putative active site [active] 320388005878 Zinc-finger domain; Region: zf-CHCC; cl01821 320388005879 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320388005880 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 320388005881 homodimer interface [polypeptide binding]; other site 320388005882 substrate-cofactor binding pocket; other site 320388005883 catalytic residue [active] 320388005884 AzlC protein; Region: AzlC; cl00570 320388005885 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 320388005886 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 320388005887 Phosphoglycerate kinase; Region: PGK; pfam00162 320388005888 substrate binding site [chemical binding]; other site 320388005889 hinge regions; other site 320388005890 ADP binding site [chemical binding]; other site 320388005891 catalytic site [active] 320388005892 pyruvate kinase; Provisional; Region: PRK05826 320388005893 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 320388005894 domain interfaces; other site 320388005895 active site 320388005896 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 320388005897 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 320388005898 intersubunit interface [polypeptide binding]; other site 320388005899 active site 320388005900 zinc binding site [ion binding]; other site 320388005901 Na+ binding site [ion binding]; other site 320388005902 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 320388005903 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 320388005904 ATP binding site [chemical binding]; other site 320388005905 active site 320388005906 substrate binding site [chemical binding]; other site 320388005907 AIR carboxylase; Region: AIRC; pfam00731 320388005908 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 320388005909 ATP-grasp domain; Region: ATP-grasp; pfam02222 320388005910 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 320388005911 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 320388005912 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 320388005913 active site 320388005914 catalytic triad [active] 320388005915 oxyanion hole [active] 320388005916 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 320388005917 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 320388005918 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 320388005919 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 320388005920 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 320388005921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388005922 active site 320388005923 phosphorylation site [posttranslational modification] 320388005924 intermolecular recognition site; other site 320388005925 dimerization interface [polypeptide binding]; other site 320388005926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388005927 DNA binding site [nucleotide binding] 320388005928 sensor protein QseC; Provisional; Region: PRK10337 320388005929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388005930 ATP binding site [chemical binding]; other site 320388005931 Mg2+ binding site [ion binding]; other site 320388005932 G-X-G motif; other site 320388005933 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320388005934 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320388005935 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388005936 protein binding site [polypeptide binding]; other site 320388005937 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388005938 protein binding site [polypeptide binding]; other site 320388005939 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 320388005940 Domain of unknown function (DUF427); Region: DUF427; pfam04248 320388005941 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320388005942 hydrophobic ligand binding site; other site 320388005943 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 320388005944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388005945 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 320388005946 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 320388005947 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388005948 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388005949 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 320388005950 Protein export membrane protein; Region: SecD_SecF; cl14618 320388005951 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 320388005952 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320388005953 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 320388005954 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388005955 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388005956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388005957 HTH-like domain; Region: HTH_21; pfam13276 320388005958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388005959 Integrase core domain; Region: rve; pfam00665 320388005960 Integrase core domain; Region: rve_3; pfam13683 320388005961 Transposase; Region: HTH_Tnp_1; pfam01527 320388005962 xanthine permease; Region: pbuX; TIGR03173 320388005963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320388005964 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 320388005965 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388005966 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320388005967 conserved cys residue [active] 320388005968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388005969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388005970 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 320388005971 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 320388005972 substrate binding site [chemical binding]; other site 320388005973 catalytic Zn binding site [ion binding]; other site 320388005974 NAD binding site [chemical binding]; other site 320388005975 structural Zn binding site [ion binding]; other site 320388005976 dimer interface [polypeptide binding]; other site 320388005977 S-formylglutathione hydrolase; Region: PLN02442 320388005978 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 320388005979 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 320388005980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 320388005981 dimer interface [polypeptide binding]; other site 320388005982 putative PBP binding regions; other site 320388005983 ABC-ATPase subunit interface; other site 320388005984 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 320388005985 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 320388005986 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 320388005987 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 320388005988 metal binding site [ion binding]; metal-binding site 320388005989 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 320388005990 metal binding site 2 [ion binding]; metal-binding site 320388005991 putative DNA binding helix; other site 320388005992 metal binding site 1 [ion binding]; metal-binding site 320388005993 dimer interface [polypeptide binding]; other site 320388005994 structural Zn2+ binding site [ion binding]; other site 320388005995 sorbitol dehydrogenase; Provisional; Region: PRK07067 320388005996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388005997 NAD(P) binding site [chemical binding]; other site 320388005998 active site 320388005999 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388006000 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320388006001 substrate binding site [chemical binding]; other site 320388006002 ATP binding site [chemical binding]; other site 320388006003 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 320388006004 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 320388006005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320388006006 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320388006007 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 320388006008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006009 dimer interface [polypeptide binding]; other site 320388006010 conserved gate region; other site 320388006011 putative PBP binding loops; other site 320388006012 ABC-ATPase subunit interface; other site 320388006013 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320388006014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006015 dimer interface [polypeptide binding]; other site 320388006016 conserved gate region; other site 320388006017 putative PBP binding loops; other site 320388006018 ABC-ATPase subunit interface; other site 320388006019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388006020 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320388006021 active site 320388006022 motif I; other site 320388006023 motif II; other site 320388006024 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 320388006025 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 320388006026 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320388006027 Walker A/P-loop; other site 320388006028 ATP binding site [chemical binding]; other site 320388006029 Q-loop/lid; other site 320388006030 ABC transporter signature motif; other site 320388006031 Walker B; other site 320388006032 D-loop; other site 320388006033 H-loop/switch region; other site 320388006034 TOBE domain; Region: TOBE; pfam03459 320388006035 TOBE domain; Region: TOBE_2; pfam08402 320388006036 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 320388006037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006039 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 320388006040 putative effector binding pocket; other site 320388006041 putative dimerization interface [polypeptide binding]; other site 320388006042 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 320388006043 Beta-lactamase; Region: Beta-lactamase; pfam00144 320388006044 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320388006045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006046 putative substrate translocation pore; other site 320388006047 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 320388006048 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 320388006049 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 320388006050 N- and C-terminal domain interface [polypeptide binding]; other site 320388006051 D-xylulose kinase; Region: XylB; TIGR01312 320388006052 active site 320388006053 MgATP binding site [chemical binding]; other site 320388006054 catalytic site [active] 320388006055 metal binding site [ion binding]; metal-binding site 320388006056 xylulose binding site [chemical binding]; other site 320388006057 homodimer interface [polypeptide binding]; other site 320388006058 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 320388006059 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 320388006060 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 320388006061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388006064 dimerization interface [polypeptide binding]; other site 320388006065 benzoylformate decarboxylase; Reviewed; Region: PRK07092 320388006066 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388006067 PYR/PP interface [polypeptide binding]; other site 320388006068 dimer interface [polypeptide binding]; other site 320388006069 TPP binding site [chemical binding]; other site 320388006070 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388006071 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 320388006072 TPP-binding site [chemical binding]; other site 320388006073 dimer interface [polypeptide binding]; other site 320388006074 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 320388006075 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 320388006076 NAD(P) binding site [chemical binding]; other site 320388006077 catalytic residues [active] 320388006078 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 320388006079 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320388006080 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320388006081 benzoate transport; Region: 2A0115; TIGR00895 320388006082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006083 putative substrate translocation pore; other site 320388006084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006085 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 320388006086 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 320388006087 kynureninase; Region: kynureninase; TIGR01814 320388006088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388006089 catalytic residue [active] 320388006090 Putative cyclase; Region: Cyclase; cl00814 320388006091 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388006092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388006093 putative DNA binding site [nucleotide binding]; other site 320388006094 putative Zn2+ binding site [ion binding]; other site 320388006095 AsnC family; Region: AsnC_trans_reg; pfam01037 320388006096 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 320388006097 methionine sulfoxide reductase A; Provisional; Region: PRK14054 320388006098 Protein of unknown function DUF72; Region: DUF72; pfam01904 320388006099 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 320388006100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388006101 S-adenosylmethionine binding site [chemical binding]; other site 320388006102 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 320388006103 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 320388006104 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 320388006105 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 320388006106 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 320388006107 putative ATP binding site [chemical binding]; other site 320388006108 putative substrate interface [chemical binding]; other site 320388006109 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 320388006110 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320388006111 catalytic residues [active] 320388006112 Pirin-related protein [General function prediction only]; Region: COG1741 320388006113 Pirin; Region: Pirin; pfam02678 320388006114 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 320388006115 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 320388006116 EamA-like transporter family; Region: EamA; pfam00892 320388006117 AMIN domain; Region: AMIN; pfam11741 320388006118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 320388006119 active site 320388006120 metal binding site [ion binding]; metal-binding site 320388006121 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 320388006122 epoxyqueuosine reductase; Region: TIGR00276 320388006123 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 320388006124 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 320388006125 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 320388006126 DNA binding site [nucleotide binding] 320388006127 active site 320388006128 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 320388006129 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 320388006130 active site 320388006131 Int/Topo IB signature motif; other site 320388006132 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320388006133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388006134 acyl-activating enzyme (AAE) consensus motif; other site 320388006135 AMP binding site [chemical binding]; other site 320388006136 active site 320388006137 CoA binding site [chemical binding]; other site 320388006138 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 320388006139 putative deacylase active site [active] 320388006140 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 320388006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 320388006142 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 320388006143 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 320388006144 FAD binding domain; Region: FAD_binding_4; pfam01565 320388006145 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 320388006146 ornithine carbamoyltransferase; Provisional; Region: PRK00779 320388006147 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320388006148 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320388006149 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 320388006150 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 320388006151 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 320388006152 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 320388006153 Uncharacterized conserved protein [Function unknown]; Region: COG2912 320388006154 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 320388006155 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 320388006156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388006157 NAD(P) binding site [chemical binding]; other site 320388006158 active site 320388006159 Transposase domain (DUF772); Region: DUF772; pfam05598 320388006160 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388006161 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388006162 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 320388006163 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320388006164 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 320388006165 isocitrate dehydrogenase; Validated; Region: PRK07362 320388006166 isocitrate dehydrogenase; Reviewed; Region: PRK07006 320388006167 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 320388006168 pseudouridine synthase; Region: TIGR00093 320388006169 active site 320388006170 Transposase; Region: HTH_Tnp_1; pfam01527 320388006171 HTH-like domain; Region: HTH_21; pfam13276 320388006172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006173 Integrase core domain; Region: rve; pfam00665 320388006174 Integrase core domain; Region: rve_3; pfam13683 320388006175 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388006176 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320388006177 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 320388006178 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 320388006179 Rubredoxin; Region: Rubredoxin; pfam00301 320388006180 iron binding site [ion binding]; other site 320388006181 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 320388006182 ABC transporter ATPase component; Reviewed; Region: PRK11147 320388006183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388006184 Walker A/P-loop; other site 320388006185 ATP binding site [chemical binding]; other site 320388006186 Q-loop/lid; other site 320388006187 ABC transporter signature motif; other site 320388006188 Walker B; other site 320388006189 D-loop; other site 320388006190 H-loop/switch region; other site 320388006191 ABC transporter; Region: ABC_tran_2; pfam12848 320388006192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388006193 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 320388006194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388006195 ATP binding site [chemical binding]; other site 320388006196 Mg2+ binding site [ion binding]; other site 320388006197 G-X-G motif; other site 320388006198 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 320388006199 anchoring element; other site 320388006200 dimer interface [polypeptide binding]; other site 320388006201 ATP binding site [chemical binding]; other site 320388006202 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 320388006203 active site 320388006204 metal binding site [ion binding]; metal-binding site 320388006205 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 320388006206 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 320388006207 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 320388006208 CAP-like domain; other site 320388006209 active site 320388006210 primary dimer interface [polypeptide binding]; other site 320388006211 Predicted integral membrane protein [Function unknown]; Region: COG5615 320388006212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388006215 dimerization interface [polypeptide binding]; other site 320388006216 Predicted membrane protein [Function unknown]; Region: COG4125 320388006217 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320388006218 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320388006219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388006222 dimerization interface [polypeptide binding]; other site 320388006223 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388006224 allantoate amidohydrolase; Reviewed; Region: PRK12893 320388006225 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 320388006226 active site 320388006227 metal binding site [ion binding]; metal-binding site 320388006228 dimer interface [polypeptide binding]; other site 320388006229 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320388006230 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 320388006231 active site 320388006232 Zn binding site [ion binding]; other site 320388006233 Chromate transporter; Region: Chromate_transp; pfam02417 320388006234 Chromate transporter; Region: Chromate_transp; pfam02417 320388006235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388006236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388006237 metal binding site [ion binding]; metal-binding site 320388006238 active site 320388006239 I-site; other site 320388006240 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320388006241 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 320388006242 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 320388006243 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 320388006244 homotrimer interaction site [polypeptide binding]; other site 320388006245 putative active site [active] 320388006246 HTH-like domain; Region: HTH_21; pfam13276 320388006247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006248 Integrase core domain; Region: rve; pfam00665 320388006249 Integrase core domain; Region: rve_3; pfam13683 320388006250 Transposase; Region: HTH_Tnp_1; pfam01527 320388006251 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 320388006252 Mg++ binding site [ion binding]; other site 320388006253 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 320388006254 putative catalytic motif [active] 320388006255 UDP-glucose 4-epimerase; Region: PLN02240 320388006256 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 320388006257 NAD binding site [chemical binding]; other site 320388006258 homodimer interface [polypeptide binding]; other site 320388006259 active site 320388006260 substrate binding site [chemical binding]; other site 320388006261 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 320388006262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388006263 putative ADP-binding pocket [chemical binding]; other site 320388006264 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320388006265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388006266 active site 320388006267 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320388006268 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320388006269 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 320388006270 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 320388006271 active site 320388006272 substrate binding site [chemical binding]; other site 320388006273 metal binding site [ion binding]; metal-binding site 320388006274 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388006275 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388006276 putative active site [active] 320388006277 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 320388006278 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 320388006279 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 320388006280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388006281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320388006282 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 320388006283 UreF; Region: UreF; pfam01730 320388006284 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 320388006285 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 320388006286 dimer interface [polypeptide binding]; other site 320388006287 catalytic residues [active] 320388006288 urease subunit alpha; Reviewed; Region: ureC; PRK13207 320388006289 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 320388006290 subunit interactions [polypeptide binding]; other site 320388006291 active site 320388006292 flap region; other site 320388006293 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 320388006294 gamma-beta subunit interface [polypeptide binding]; other site 320388006295 alpha-beta subunit interface [polypeptide binding]; other site 320388006296 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 320388006297 alpha-gamma subunit interface [polypeptide binding]; other site 320388006298 beta-gamma subunit interface [polypeptide binding]; other site 320388006299 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 320388006300 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 320388006301 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388006302 Walker A/P-loop; other site 320388006303 ATP binding site [chemical binding]; other site 320388006304 Q-loop/lid; other site 320388006305 ABC transporter signature motif; other site 320388006306 Walker B; other site 320388006307 D-loop; other site 320388006308 H-loop/switch region; other site 320388006309 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 320388006310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388006311 Walker A/P-loop; other site 320388006312 ATP binding site [chemical binding]; other site 320388006313 Q-loop/lid; other site 320388006314 ABC transporter signature motif; other site 320388006315 Walker B; other site 320388006316 D-loop; other site 320388006317 H-loop/switch region; other site 320388006318 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388006319 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388006320 TM-ABC transporter signature motif; other site 320388006321 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388006322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388006323 TM-ABC transporter signature motif; other site 320388006324 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320388006325 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 320388006326 putative ligand binding site [chemical binding]; other site 320388006327 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 320388006328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388006329 inhibitor-cofactor binding pocket; inhibition site 320388006330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388006331 catalytic residue [active] 320388006332 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 320388006333 active site residue [active] 320388006334 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 320388006335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388006336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388006337 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 320388006338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388006339 FeS/SAM binding site; other site 320388006340 HemN C-terminal domain; Region: HemN_C; pfam06969 320388006341 Flagellin N-methylase; Region: FliB; pfam03692 320388006342 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 320388006343 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 320388006344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388006345 S-adenosylmethionine binding site [chemical binding]; other site 320388006346 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 320388006347 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388006348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388006349 S-adenosylmethionine binding site [chemical binding]; other site 320388006350 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320388006351 active site 320388006352 catalytic triad [active] 320388006353 calcium binding site [ion binding]; other site 320388006354 chromosome condensation membrane protein; Provisional; Region: PRK14196 320388006355 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 320388006356 YGGT family; Region: YGGT; pfam02325 320388006357 YGGT family; Region: YGGT; pfam02325 320388006358 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 320388006359 Rossmann-like domain; Region: Rossmann-like; pfam10727 320388006360 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 320388006361 serine racemase; Region: PLN02970 320388006362 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320388006363 tetramer interface [polypeptide binding]; other site 320388006364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388006365 catalytic residue [active] 320388006366 LysE type translocator; Region: LysE; cl00565 320388006367 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 320388006368 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320388006369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320388006370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320388006371 catalytic residue [active] 320388006372 aminotransferase; Validated; Region: PRK07337 320388006373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388006374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388006375 homodimer interface [polypeptide binding]; other site 320388006376 catalytic residue [active] 320388006377 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 320388006378 putative RNA binding site [nucleotide binding]; other site 320388006379 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 320388006380 homopentamer interface [polypeptide binding]; other site 320388006381 active site 320388006382 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 320388006383 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 320388006384 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 320388006385 dimerization interface [polypeptide binding]; other site 320388006386 active site 320388006387 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 320388006388 Lumazine binding domain; Region: Lum_binding; pfam00677 320388006389 Lumazine binding domain; Region: Lum_binding; pfam00677 320388006390 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 320388006391 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 320388006392 catalytic motif [active] 320388006393 Zn binding site [ion binding]; other site 320388006394 RibD C-terminal domain; Region: RibD_C; cl17279 320388006395 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 320388006396 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388006397 inhibitor-cofactor binding pocket; inhibition site 320388006398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388006399 catalytic residue [active] 320388006400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006401 putative substrate translocation pore; other site 320388006402 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 320388006403 D-cysteine desulfhydrase; Validated; Region: PRK03910 320388006404 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 320388006405 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388006406 catalytic residue [active] 320388006407 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320388006408 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388006409 Walker A/P-loop; other site 320388006410 ATP binding site [chemical binding]; other site 320388006411 Q-loop/lid; other site 320388006412 ABC transporter signature motif; other site 320388006413 Walker B; other site 320388006414 D-loop; other site 320388006415 H-loop/switch region; other site 320388006416 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006418 dimer interface [polypeptide binding]; other site 320388006419 conserved gate region; other site 320388006420 putative PBP binding loops; other site 320388006421 ABC-ATPase subunit interface; other site 320388006422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388006423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388006424 substrate binding pocket [chemical binding]; other site 320388006425 membrane-bound complex binding site; other site 320388006426 hinge residues; other site 320388006427 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 320388006428 Glucokinase; Region: Glucokinase; pfam02685 320388006429 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388006430 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320388006431 putative active site [active] 320388006432 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 320388006433 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 320388006434 putative active site [active] 320388006435 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 320388006436 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 320388006437 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 320388006438 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320388006439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320388006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006441 dimer interface [polypeptide binding]; other site 320388006442 conserved gate region; other site 320388006443 putative PBP binding loops; other site 320388006444 ABC-ATPase subunit interface; other site 320388006445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320388006446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006447 dimer interface [polypeptide binding]; other site 320388006448 conserved gate region; other site 320388006449 putative PBP binding loops; other site 320388006450 ABC-ATPase subunit interface; other site 320388006451 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320388006452 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320388006453 Walker A/P-loop; other site 320388006454 ATP binding site [chemical binding]; other site 320388006455 Q-loop/lid; other site 320388006456 ABC transporter signature motif; other site 320388006457 Walker B; other site 320388006458 D-loop; other site 320388006459 H-loop/switch region; other site 320388006460 Predicted membrane protein [Function unknown]; Region: COG2860 320388006461 UPF0126 domain; Region: UPF0126; pfam03458 320388006462 UPF0126 domain; Region: UPF0126; pfam03458 320388006463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 320388006464 Smr domain; Region: Smr; pfam01713 320388006465 thioredoxin reductase; Provisional; Region: PRK10262 320388006466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388006467 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 320388006468 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 320388006469 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 320388006470 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 320388006471 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 320388006472 recombination factor protein RarA; Reviewed; Region: PRK13342 320388006473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388006474 Walker A motif; other site 320388006475 ATP binding site [chemical binding]; other site 320388006476 Walker B motif; other site 320388006477 arginine finger; other site 320388006478 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 320388006479 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 320388006480 seryl-tRNA synthetase; Provisional; Region: PRK05431 320388006481 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 320388006482 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 320388006483 dimer interface [polypeptide binding]; other site 320388006484 active site 320388006485 motif 1; other site 320388006486 motif 2; other site 320388006487 motif 3; other site 320388006488 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320388006489 septum formation inhibitor; Reviewed; Region: PRK01973 320388006490 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 320388006491 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 320388006492 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 320388006493 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 320388006494 Switch I; other site 320388006495 Switch II; other site 320388006496 cell division topological specificity factor MinE; Provisional; Region: PRK13989 320388006497 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320388006498 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 320388006499 putative ion selectivity filter; other site 320388006500 putative pore gating glutamate residue; other site 320388006501 putative H+/Cl- coupling transport residue; other site 320388006502 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388006503 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388006504 putative active site [active] 320388006505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006506 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388006507 putative substrate translocation pore; other site 320388006508 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 320388006509 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320388006510 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 320388006511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388006512 FeS/SAM binding site; other site 320388006513 HemN C-terminal domain; Region: HemN_C; pfam06969 320388006514 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 320388006515 active site 320388006516 dimerization interface [polypeptide binding]; other site 320388006517 ribonuclease PH; Reviewed; Region: rph; PRK00173 320388006518 Ribonuclease PH; Region: RNase_PH_bact; cd11362 320388006519 hexamer interface [polypeptide binding]; other site 320388006520 active site 320388006521 hypothetical protein; Provisional; Region: PRK11820 320388006522 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 320388006523 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 320388006524 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 320388006525 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 320388006526 catalytic site [active] 320388006527 G-X2-G-X-G-K; other site 320388006528 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 320388006529 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 320388006530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320388006531 Zn2+ binding site [ion binding]; other site 320388006532 Mg2+ binding site [ion binding]; other site 320388006533 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 320388006534 synthetase active site [active] 320388006535 NTP binding site [chemical binding]; other site 320388006536 metal binding site [ion binding]; metal-binding site 320388006537 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 320388006538 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 320388006539 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 320388006540 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 320388006541 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320388006542 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388006543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388006544 Transposase; Region: HTH_Tnp_1; pfam01527 320388006545 HTH-like domain; Region: HTH_21; pfam13276 320388006546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006547 Integrase core domain; Region: rve; pfam00665 320388006548 Integrase core domain; Region: rve_3; pfam13683 320388006549 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 320388006550 Tetratricopeptide repeat; Region: TPR_6; pfam13174 320388006551 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320388006552 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388006553 ligand binding site [chemical binding]; other site 320388006554 translocation protein TolB; Provisional; Region: tolB; PRK02889 320388006555 TolB amino-terminal domain; Region: TolB_N; pfam04052 320388006556 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320388006557 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320388006558 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320388006559 TolA protein; Region: tolA_full; TIGR02794 320388006560 TonB C terminal; Region: TonB_2; pfam13103 320388006561 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320388006562 TolR protein; Region: tolR; TIGR02801 320388006563 TolQ protein; Region: tolQ; TIGR02796 320388006564 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320388006565 active site 320388006566 malonic semialdehyde reductase; Provisional; Region: PRK10538 320388006567 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 320388006568 putative NAD(P) binding site [chemical binding]; other site 320388006569 homodimer interface [polypeptide binding]; other site 320388006570 homotetramer interface [polypeptide binding]; other site 320388006571 active site 320388006572 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 320388006573 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 320388006574 dimer interface [polypeptide binding]; other site 320388006575 active site 320388006576 glycine-pyridoxal phosphate binding site [chemical binding]; other site 320388006577 folate binding site [chemical binding]; other site 320388006578 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 320388006579 ATP cone domain; Region: ATP-cone; pfam03477 320388006580 Type II transport protein GspH; Region: GspH; pfam12019 320388006581 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 320388006582 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 320388006583 Predicted membrane protein [Function unknown]; Region: COG5393 320388006584 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 320388006585 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320388006586 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 320388006587 dimer interface [polypeptide binding]; other site 320388006588 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320388006589 catalytic triad [active] 320388006590 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 320388006591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388006592 FAD binding site [chemical binding]; other site 320388006593 substrate binding pocket [chemical binding]; other site 320388006594 catalytic base [active] 320388006595 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388006596 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388006597 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388006598 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320388006599 EAL domain; Region: EAL; pfam00563 320388006600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320388006601 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 320388006602 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320388006603 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 320388006604 benzoate transport; Region: 2A0115; TIGR00895 320388006605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006606 putative substrate translocation pore; other site 320388006607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006608 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 320388006609 fumarylacetoacetase; Region: PLN02856 320388006610 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 320388006611 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320388006612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388006614 putative substrate translocation pore; other site 320388006615 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320388006616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006617 putative substrate translocation pore; other site 320388006618 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 320388006619 putative FMN binding site [chemical binding]; other site 320388006620 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320388006621 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 320388006622 putative ligand binding site [chemical binding]; other site 320388006623 putative NAD binding site [chemical binding]; other site 320388006624 catalytic site [active] 320388006625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006627 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388006628 putative effector binding pocket; other site 320388006629 dimerization interface [polypeptide binding]; other site 320388006630 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 320388006631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388006632 catalytic residue [active] 320388006633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388006634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388006635 EamA-like transporter family; Region: EamA; pfam00892 320388006636 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320388006637 EamA-like transporter family; Region: EamA; pfam00892 320388006638 major facilitator superfamily transporter; Provisional; Region: PRK05122 320388006639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006640 putative substrate translocation pore; other site 320388006641 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 320388006642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388006643 catalytic loop [active] 320388006644 iron binding site [ion binding]; other site 320388006645 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 320388006646 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 320388006647 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 320388006648 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 320388006649 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 320388006650 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320388006651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320388006652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 320388006653 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 320388006654 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388006655 N-terminal plug; other site 320388006656 ligand-binding site [chemical binding]; other site 320388006657 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320388006658 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320388006659 Walker A/P-loop; other site 320388006660 ATP binding site [chemical binding]; other site 320388006661 Q-loop/lid; other site 320388006662 ABC transporter signature motif; other site 320388006663 Walker B; other site 320388006664 D-loop; other site 320388006665 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 320388006666 intersubunit interface [polypeptide binding]; other site 320388006667 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 320388006668 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 320388006669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320388006670 dimer interface [polypeptide binding]; other site 320388006671 putative PBP binding regions; other site 320388006672 ABC-ATPase subunit interface; other site 320388006673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388006676 dimerization interface [polypeptide binding]; other site 320388006677 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 320388006678 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 320388006679 putative catalytic residue [active] 320388006680 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 320388006681 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 320388006682 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 320388006683 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 320388006684 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320388006685 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320388006686 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 320388006687 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006689 putative substrate translocation pore; other site 320388006690 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 320388006691 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 320388006692 putative active site [active] 320388006693 catalytic site [active] 320388006694 putative metal binding site [ion binding]; other site 320388006695 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388006696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388006697 Coenzyme A binding pocket [chemical binding]; other site 320388006698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320388006699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388006700 non-specific DNA binding site [nucleotide binding]; other site 320388006701 salt bridge; other site 320388006702 sequence-specific DNA binding site [nucleotide binding]; other site 320388006703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320388006704 Predicted transcriptional regulators [Transcription]; Region: COG1733 320388006705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388006706 dimerization interface [polypeptide binding]; other site 320388006707 putative DNA binding site [nucleotide binding]; other site 320388006708 putative Zn2+ binding site [ion binding]; other site 320388006709 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388006710 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388006711 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320388006712 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 320388006713 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320388006714 putative NAD(P) binding site [chemical binding]; other site 320388006715 Predicted transcriptional regulators [Transcription]; Region: COG1733 320388006716 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320388006717 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320388006718 oligomerisation interface [polypeptide binding]; other site 320388006719 mobile loop; other site 320388006720 roof hairpin; other site 320388006721 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 320388006722 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 320388006723 ring oligomerisation interface [polypeptide binding]; other site 320388006724 ATP/Mg binding site [chemical binding]; other site 320388006725 stacking interactions; other site 320388006726 hinge regions; other site 320388006727 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320388006728 dimer interface [polypeptide binding]; other site 320388006729 substrate binding site [chemical binding]; other site 320388006730 ATP binding site [chemical binding]; other site 320388006731 Rubredoxin [Energy production and conversion]; Region: COG1773 320388006732 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 320388006733 iron binding site [ion binding]; other site 320388006734 hypothetical protein; Validated; Region: PRK00228 320388006735 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 320388006736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388006737 active site 320388006738 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 320388006739 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320388006740 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320388006741 dihydroorotase; Provisional; Region: PRK07627 320388006742 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388006743 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 320388006744 active site 320388006745 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320388006746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320388006747 putative acyl-acceptor binding pocket; other site 320388006748 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 320388006749 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 320388006750 active site 320388006751 metal binding site [ion binding]; metal-binding site 320388006752 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 320388006753 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 320388006754 NAD binding site [chemical binding]; other site 320388006755 substrate binding site [chemical binding]; other site 320388006756 homodimer interface [polypeptide binding]; other site 320388006757 active site 320388006758 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 320388006759 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 320388006760 substrate binding site; other site 320388006761 tetramer interface; other site 320388006762 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 320388006763 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 320388006764 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 320388006765 NADP binding site [chemical binding]; other site 320388006766 active site 320388006767 putative substrate binding site [chemical binding]; other site 320388006768 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 320388006769 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320388006770 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 320388006771 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 320388006772 Walker A/P-loop; other site 320388006773 ATP binding site [chemical binding]; other site 320388006774 Q-loop/lid; other site 320388006775 ABC transporter signature motif; other site 320388006776 Walker B; other site 320388006777 D-loop; other site 320388006778 H-loop/switch region; other site 320388006779 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 320388006780 putative carbohydrate binding site [chemical binding]; other site 320388006781 Acyltransferase family; Region: Acyl_transf_3; pfam01757 320388006782 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388006783 extended (e) SDRs; Region: SDR_e; cd08946 320388006784 NAD(P) binding site [chemical binding]; other site 320388006785 active site 320388006786 substrate binding site [chemical binding]; other site 320388006787 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320388006788 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 320388006789 Probable Catalytic site; other site 320388006790 metal-binding site 320388006791 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388006792 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320388006793 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320388006794 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 320388006795 active site 320388006796 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320388006797 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 320388006798 Probable Catalytic site; other site 320388006799 metal-binding site 320388006800 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320388006801 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 320388006802 active site 320388006803 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320388006804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388006805 active site 320388006806 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388006807 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388006808 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 320388006809 putative NAD(P) binding site [chemical binding]; other site 320388006810 active site 320388006811 putative substrate binding site [chemical binding]; other site 320388006812 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 320388006813 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 320388006814 Mg++ binding site [ion binding]; other site 320388006815 putative catalytic motif [active] 320388006816 putative substrate binding site [chemical binding]; other site 320388006817 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 320388006818 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 320388006819 NAD(P) binding site [chemical binding]; other site 320388006820 homodimer interface [polypeptide binding]; other site 320388006821 substrate binding site [chemical binding]; other site 320388006822 active site 320388006823 HTH-like domain; Region: HTH_21; pfam13276 320388006824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006825 Integrase core domain; Region: rve; pfam00665 320388006826 Integrase core domain; Region: rve_3; pfam13683 320388006827 Transposase; Region: HTH_Tnp_1; pfam01527 320388006828 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388006829 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388006830 TM-ABC transporter signature motif; other site 320388006831 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388006832 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388006833 TM-ABC transporter signature motif; other site 320388006834 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388006835 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388006836 Walker A/P-loop; other site 320388006837 ATP binding site [chemical binding]; other site 320388006838 Q-loop/lid; other site 320388006839 ABC transporter signature motif; other site 320388006840 Walker B; other site 320388006841 D-loop; other site 320388006842 H-loop/switch region; other site 320388006843 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388006844 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388006845 Walker A/P-loop; other site 320388006846 ATP binding site [chemical binding]; other site 320388006847 Q-loop/lid; other site 320388006848 ABC transporter signature motif; other site 320388006849 Walker B; other site 320388006850 D-loop; other site 320388006851 H-loop/switch region; other site 320388006852 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 320388006853 putative acetyltransferase; Provisional; Region: PRK03624 320388006854 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320388006855 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 320388006856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388006857 inhibitor-cofactor binding pocket; inhibition site 320388006858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388006859 catalytic residue [active] 320388006860 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 320388006861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388006862 catalytic loop [active] 320388006863 iron binding site [ion binding]; other site 320388006864 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 320388006865 FAD binding pocket [chemical binding]; other site 320388006866 FAD binding motif [chemical binding]; other site 320388006867 phosphate binding motif [ion binding]; other site 320388006868 beta-alpha-beta structure motif; other site 320388006869 NAD binding pocket [chemical binding]; other site 320388006870 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320388006871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388006872 NAD(P) binding site [chemical binding]; other site 320388006873 active site 320388006874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388006875 RNA binding surface [nucleotide binding]; other site 320388006876 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320388006877 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 320388006878 active site 320388006879 uracil binding [chemical binding]; other site 320388006880 CopC domain; Region: CopC; pfam04234 320388006881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388006884 dimerization interface [polypeptide binding]; other site 320388006885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388006886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388006887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388006888 dimerization interface [polypeptide binding]; other site 320388006889 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388006890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 320388006891 MOSC domain; Region: MOSC; pfam03473 320388006892 3-alpha domain; Region: 3-alpha; pfam03475 320388006893 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 320388006894 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 320388006895 inhibitor site; inhibition site 320388006896 active site 320388006897 dimer interface [polypeptide binding]; other site 320388006898 catalytic residue [active] 320388006899 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 320388006900 intersubunit interface [polypeptide binding]; other site 320388006901 active site 320388006902 Zn2+ binding site [ion binding]; other site 320388006903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320388006904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388006905 non-specific DNA binding site [nucleotide binding]; other site 320388006906 salt bridge; other site 320388006907 sequence-specific DNA binding site [nucleotide binding]; other site 320388006908 Cupin domain; Region: Cupin_2; pfam07883 320388006909 HTH-like domain; Region: HTH_21; pfam13276 320388006910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006911 Integrase core domain; Region: rve; pfam00665 320388006912 Integrase core domain; Region: rve_3; pfam13683 320388006913 Transposase; Region: HTH_Tnp_1; pfam01527 320388006914 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 320388006915 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 320388006916 active site 320388006917 homotetramer interface [polypeptide binding]; other site 320388006918 Predicted ATPase [General function prediction only]; Region: COG3911 320388006919 AAA domain; Region: AAA_28; pfam13521 320388006920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388006921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388006922 putative substrate translocation pore; other site 320388006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 320388006924 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 320388006925 substrate binding site [chemical binding]; other site 320388006926 ecotin; Provisional; Region: PRK03719 320388006927 secondary substrate binding site; other site 320388006928 primary substrate binding site; other site 320388006929 inhibition loop; other site 320388006930 dimerization interface [polypeptide binding]; other site 320388006931 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320388006932 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320388006933 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 320388006934 Transposase; Region: HTH_Tnp_1; pfam01527 320388006935 HTH-like domain; Region: HTH_21; pfam13276 320388006936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388006937 Integrase core domain; Region: rve; pfam00665 320388006938 Integrase core domain; Region: rve_3; pfam13683 320388006939 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320388006940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388006941 Walker A/P-loop; other site 320388006942 ATP binding site [chemical binding]; other site 320388006943 Q-loop/lid; other site 320388006944 ABC transporter signature motif; other site 320388006945 Walker B; other site 320388006946 D-loop; other site 320388006947 H-loop/switch region; other site 320388006948 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388006949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006950 dimer interface [polypeptide binding]; other site 320388006951 conserved gate region; other site 320388006952 putative PBP binding loops; other site 320388006953 ABC-ATPase subunit interface; other site 320388006954 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388006955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006956 dimer interface [polypeptide binding]; other site 320388006957 conserved gate region; other site 320388006958 putative PBP binding loops; other site 320388006959 ABC-ATPase subunit interface; other site 320388006960 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320388006961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388006962 substrate binding pocket [chemical binding]; other site 320388006963 membrane-bound complex binding site; other site 320388006964 hinge residues; other site 320388006965 Pirin-related protein [General function prediction only]; Region: COG1741 320388006966 Pirin; Region: Pirin; pfam02678 320388006967 Pirin-related protein [General function prediction only]; Region: COG1741 320388006968 osmolarity response regulator; Provisional; Region: ompR; PRK09468 320388006969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388006970 active site 320388006971 phosphorylation site [posttranslational modification] 320388006972 intermolecular recognition site; other site 320388006973 dimerization interface [polypeptide binding]; other site 320388006974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388006975 DNA binding site [nucleotide binding] 320388006976 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 320388006977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388006978 dimer interface [polypeptide binding]; other site 320388006979 phosphorylation site [posttranslational modification] 320388006980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388006981 ATP binding site [chemical binding]; other site 320388006982 Mg2+ binding site [ion binding]; other site 320388006983 G-X-G motif; other site 320388006984 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 320388006985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006986 dimer interface [polypeptide binding]; other site 320388006987 conserved gate region; other site 320388006988 putative PBP binding loops; other site 320388006989 ABC-ATPase subunit interface; other site 320388006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388006991 dimer interface [polypeptide binding]; other site 320388006992 conserved gate region; other site 320388006993 putative PBP binding loops; other site 320388006994 ABC-ATPase subunit interface; other site 320388006995 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320388006996 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320388006997 Walker A/P-loop; other site 320388006998 ATP binding site [chemical binding]; other site 320388006999 Q-loop/lid; other site 320388007000 ABC transporter signature motif; other site 320388007001 Walker B; other site 320388007002 D-loop; other site 320388007003 H-loop/switch region; other site 320388007004 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 320388007005 HTH-like domain; Region: HTH_21; pfam13276 320388007006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007007 Integrase core domain; Region: rve; pfam00665 320388007008 Integrase core domain; Region: rve_3; pfam13683 320388007009 Transposase; Region: HTH_Tnp_1; pfam01527 320388007010 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 320388007011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007013 homodimer interface [polypeptide binding]; other site 320388007014 catalytic residue [active] 320388007015 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388007016 EamA-like transporter family; Region: EamA; pfam00892 320388007017 EamA-like transporter family; Region: EamA; pfam00892 320388007018 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 320388007019 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388007020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388007021 DNA-binding site [nucleotide binding]; DNA binding site 320388007022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007024 homodimer interface [polypeptide binding]; other site 320388007025 catalytic residue [active] 320388007026 heat shock protein 90; Provisional; Region: PRK05218 320388007027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388007028 ATP binding site [chemical binding]; other site 320388007029 Mg2+ binding site [ion binding]; other site 320388007030 G-X-G motif; other site 320388007031 Chorismate lyase; Region: Chor_lyase; cl01230 320388007032 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 320388007033 putative active site [active] 320388007034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388007035 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 320388007036 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 320388007037 Na binding site [ion binding]; other site 320388007038 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320388007039 dimer interface [polypeptide binding]; other site 320388007040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388007041 transaldolase-like protein; Provisional; Region: PTZ00411 320388007042 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 320388007043 active site 320388007044 dimer interface [polypeptide binding]; other site 320388007045 catalytic residue [active] 320388007046 Benzoate membrane transport protein; Region: BenE; pfam03594 320388007047 benzoate transporter; Region: benE; TIGR00843 320388007048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 320388007049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320388007050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388007051 Walker A motif; other site 320388007052 ATP binding site [chemical binding]; other site 320388007053 Walker B motif; other site 320388007054 arginine finger; other site 320388007055 Cytochrome c553 [Energy production and conversion]; Region: COG2863 320388007056 Cytochrome c; Region: Cytochrom_C; cl11414 320388007057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388007058 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388007059 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 320388007060 EamA-like transporter family; Region: EamA; pfam00892 320388007061 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 320388007062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320388007063 minor groove reading motif; other site 320388007064 helix-hairpin-helix signature motif; other site 320388007065 substrate binding pocket [chemical binding]; other site 320388007066 active site 320388007067 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 320388007068 ferredoxin; Provisional; Region: PRK06991 320388007069 Putative Fe-S cluster; Region: FeS; pfam04060 320388007070 4Fe-4S binding domain; Region: Fer4; pfam00037 320388007071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388007072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388007073 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 320388007074 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 320388007075 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 320388007076 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 320388007077 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 320388007078 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 320388007079 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 320388007080 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 320388007081 META domain; Region: META; pfam03724 320388007082 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 320388007083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388007084 ATP-grasp domain; Region: ATP-grasp; pfam02222 320388007085 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 320388007086 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320388007087 DEAD-like helicases superfamily; Region: DEXDc; smart00487 320388007088 ATP binding site [chemical binding]; other site 320388007089 Mg++ binding site [ion binding]; other site 320388007090 motif III; other site 320388007091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388007092 nucleotide binding region [chemical binding]; other site 320388007093 ATP-binding site [chemical binding]; other site 320388007094 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 320388007095 active site 320388007096 HIGH motif; other site 320388007097 nucleotide binding site [chemical binding]; other site 320388007098 KMSKS motif; other site 320388007099 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 320388007100 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 320388007101 putative active site [active] 320388007102 putative PHP Thumb interface [polypeptide binding]; other site 320388007103 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 320388007104 generic binding surface II; other site 320388007105 generic binding surface I; other site 320388007106 rhodanese superfamily protein; Provisional; Region: PRK05320 320388007107 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 320388007108 active site residue [active] 320388007109 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 320388007110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320388007111 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320388007112 Walker A/P-loop; other site 320388007113 ATP binding site [chemical binding]; other site 320388007114 Q-loop/lid; other site 320388007115 ABC transporter signature motif; other site 320388007116 Walker B; other site 320388007117 D-loop; other site 320388007118 H-loop/switch region; other site 320388007119 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 320388007120 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320388007121 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388007122 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388007123 putative active site [active] 320388007124 O-Antigen ligase; Region: Wzy_C; cl04850 320388007125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388007126 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 320388007127 putative ADP-binding pocket [chemical binding]; other site 320388007128 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320388007129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388007130 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320388007131 putative active site [active] 320388007132 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 320388007133 putative metal binding site; other site 320388007134 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 320388007135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388007136 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 320388007137 Uncharacterized conserved protein [Function unknown]; Region: COG2128 320388007138 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 320388007139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388007140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388007141 DNA binding residues [nucleotide binding] 320388007142 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 320388007143 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 320388007144 Pectinacetylesterase; Region: PAE; pfam03283 320388007145 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 320388007146 ribonuclease G; Provisional; Region: PRK11712 320388007147 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 320388007148 homodimer interface [polypeptide binding]; other site 320388007149 oligonucleotide binding site [chemical binding]; other site 320388007150 Maf-like protein; Region: Maf; pfam02545 320388007151 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 320388007152 active site 320388007153 dimer interface [polypeptide binding]; other site 320388007154 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 320388007155 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 320388007156 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 320388007157 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 320388007158 active site 320388007159 (T/H)XGH motif; other site 320388007160 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 320388007161 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 320388007162 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 320388007163 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 320388007164 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 320388007165 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 320388007166 hypothetical protein; Validated; Region: PRK00110 320388007167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388007168 active site 320388007169 short chain dehydrogenase; Provisional; Region: PRK08339 320388007170 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 320388007171 putative NAD(P) binding site [chemical binding]; other site 320388007172 putative active site [active] 320388007173 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 320388007174 active site 320388007175 dimer interfaces [polypeptide binding]; other site 320388007176 catalytic residues [active] 320388007177 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 320388007178 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320388007179 NADP binding site [chemical binding]; other site 320388007180 dimer interface [polypeptide binding]; other site 320388007181 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 320388007182 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 320388007183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320388007184 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 320388007185 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 320388007186 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 320388007187 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 320388007188 Ligand Binding Site [chemical binding]; other site 320388007189 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 320388007190 GAF domain; Region: GAF_3; pfam13492 320388007191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388007192 dimer interface [polypeptide binding]; other site 320388007193 phosphorylation site [posttranslational modification] 320388007194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388007195 ATP binding site [chemical binding]; other site 320388007196 Mg2+ binding site [ion binding]; other site 320388007197 G-X-G motif; other site 320388007198 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 320388007199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007200 active site 320388007201 phosphorylation site [posttranslational modification] 320388007202 intermolecular recognition site; other site 320388007203 dimerization interface [polypeptide binding]; other site 320388007204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388007205 DNA binding site [nucleotide binding] 320388007206 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 320388007207 Domain of unknown function (DUF333); Region: DUF333; pfam03891 320388007208 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 320388007209 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 320388007210 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 320388007211 FtsX-like permease family; Region: FtsX; pfam02687 320388007212 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 320388007213 apolar tunnel; other site 320388007214 heme binding site [chemical binding]; other site 320388007215 dimerization interface [polypeptide binding]; other site 320388007216 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 320388007217 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320388007218 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 320388007219 amidase; Provisional; Region: PRK07042 320388007220 Amidase; Region: Amidase; cl11426 320388007221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388007222 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388007223 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388007224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007225 putative substrate translocation pore; other site 320388007226 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 320388007227 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320388007228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 320388007229 glucose-1-dehydrogenase; Provisional; Region: PRK06947 320388007230 classical (c) SDRs; Region: SDR_c; cd05233 320388007231 NAD(P) binding site [chemical binding]; other site 320388007232 active site 320388007233 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 320388007234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388007235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388007236 Bacterial transcriptional repressor; Region: TetR; pfam13972 320388007237 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 320388007238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388007239 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 320388007240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388007241 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 320388007242 putative active site [active] 320388007243 putative metal binding site [ion binding]; other site 320388007244 RDD family; Region: RDD; pfam06271 320388007245 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 320388007246 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 320388007247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388007248 RNA polymerase factor sigma-70; Validated; Region: PRK09047 320388007249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388007250 DNA binding residues [nucleotide binding] 320388007251 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 320388007252 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388007253 PYR/PP interface [polypeptide binding]; other site 320388007254 dimer interface [polypeptide binding]; other site 320388007255 TPP binding site [chemical binding]; other site 320388007256 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388007257 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 320388007258 TPP-binding site [chemical binding]; other site 320388007259 dimer interface [polypeptide binding]; other site 320388007260 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 320388007261 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 320388007262 putative valine binding site [chemical binding]; other site 320388007263 dimer interface [polypeptide binding]; other site 320388007264 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 320388007265 ketol-acid reductoisomerase; Provisional; Region: PRK05479 320388007266 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 320388007267 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 320388007268 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 320388007269 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 320388007270 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 320388007271 2-isopropylmalate synthase; Validated; Region: PRK00915 320388007272 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 320388007273 active site 320388007274 metal binding site [ion binding]; metal-binding site 320388007275 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 320388007276 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320388007277 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 320388007278 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320388007279 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 320388007280 active site clefts [active] 320388007281 zinc binding site [ion binding]; other site 320388007282 dimer interface [polypeptide binding]; other site 320388007283 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320388007284 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 320388007285 putative ligand binding site [chemical binding]; other site 320388007286 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 320388007287 16S/18S rRNA binding site [nucleotide binding]; other site 320388007288 S13e-L30e interaction site [polypeptide binding]; other site 320388007289 25S rRNA binding site [nucleotide binding]; other site 320388007290 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 320388007291 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 320388007292 RNase E interface [polypeptide binding]; other site 320388007293 trimer interface [polypeptide binding]; other site 320388007294 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 320388007295 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 320388007296 RNase E interface [polypeptide binding]; other site 320388007297 trimer interface [polypeptide binding]; other site 320388007298 active site 320388007299 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 320388007300 putative nucleic acid binding region [nucleotide binding]; other site 320388007301 G-X-X-G motif; other site 320388007302 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 320388007303 RNA binding site [nucleotide binding]; other site 320388007304 domain interface; other site 320388007305 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 320388007306 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 320388007307 NAD(P) binding site [chemical binding]; other site 320388007308 triosephosphate isomerase; Provisional; Region: PRK14567 320388007309 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 320388007310 substrate binding site [chemical binding]; other site 320388007311 dimer interface [polypeptide binding]; other site 320388007312 catalytic triad [active] 320388007313 Preprotein translocase SecG subunit; Region: SecG; pfam03840 320388007314 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 320388007315 NADH dehydrogenase subunit B; Validated; Region: PRK06411 320388007316 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 320388007317 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 320388007318 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 320388007319 NADH dehydrogenase subunit D; Validated; Region: PRK06075 320388007320 NADH dehydrogenase subunit E; Validated; Region: PRK07539 320388007321 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 320388007322 putative dimer interface [polypeptide binding]; other site 320388007323 [2Fe-2S] cluster binding site [ion binding]; other site 320388007324 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 320388007325 SLBB domain; Region: SLBB; pfam10531 320388007326 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 320388007327 NADH dehydrogenase subunit G; Validated; Region: PRK09129 320388007328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388007329 catalytic loop [active] 320388007330 iron binding site [ion binding]; other site 320388007331 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 320388007332 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 320388007333 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 320388007334 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 320388007335 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 320388007336 4Fe-4S binding domain; Region: Fer4; cl02805 320388007337 4Fe-4S binding domain; Region: Fer4; pfam00037 320388007338 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 320388007339 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 320388007340 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 320388007341 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 320388007342 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 320388007343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320388007344 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 320388007345 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320388007346 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 320388007347 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320388007348 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 320388007349 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 320388007350 dimer interface [polypeptide binding]; other site 320388007351 ADP-ribose binding site [chemical binding]; other site 320388007352 active site 320388007353 nudix motif; other site 320388007354 metal binding site [ion binding]; metal-binding site 320388007355 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 320388007356 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 320388007357 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 320388007358 FAD binding site [chemical binding]; other site 320388007359 substrate binding site [chemical binding]; other site 320388007360 catalytic base [active] 320388007361 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 320388007362 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 320388007363 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320388007364 active site 320388007365 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 320388007366 putative active site [active] 320388007367 putative catalytic site [active] 320388007368 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 320388007369 putative active site [active] 320388007370 putative catalytic site [active] 320388007371 Right handed beta helix region; Region: Beta_helix; pfam13229 320388007372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388007373 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 320388007374 FAD binding site [chemical binding]; other site 320388007375 substrate binding site [chemical binding]; other site 320388007376 catalytic base [active] 320388007377 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 320388007378 putative active site [active] 320388007379 putative substrate binding site [chemical binding]; other site 320388007380 ATP binding site [chemical binding]; other site 320388007381 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388007382 catalytic core [active] 320388007383 enoyl-CoA hydratase; Provisional; Region: PRK07511 320388007384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388007385 substrate binding site [chemical binding]; other site 320388007386 oxyanion hole (OAH) forming residues; other site 320388007387 trimer interface [polypeptide binding]; other site 320388007388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320388007389 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320388007390 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320388007391 C-terminal domain interface [polypeptide binding]; other site 320388007392 GSH binding site (G-site) [chemical binding]; other site 320388007393 dimer interface [polypeptide binding]; other site 320388007394 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 320388007395 putative N-terminal domain interface [polypeptide binding]; other site 320388007396 putative dimer interface [polypeptide binding]; other site 320388007397 putative substrate binding pocket (H-site) [chemical binding]; other site 320388007398 methionine aminotransferase; Validated; Region: PRK09082 320388007399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007401 homodimer interface [polypeptide binding]; other site 320388007402 catalytic residue [active] 320388007403 PIN domain; Region: PIN_3; pfam13470 320388007404 PIN domain; Region: PIN_3; cl17397 320388007405 hypothetical protein; Validated; Region: PRK02101 320388007406 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 320388007407 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 320388007408 putative active site [active] 320388007409 Zn binding site [ion binding]; other site 320388007410 Predicted membrane protein [Function unknown]; Region: COG3235 320388007411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388007412 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 320388007413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388007414 DNA binding residues [nucleotide binding] 320388007415 dimerization interface [polypeptide binding]; other site 320388007416 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 320388007417 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 320388007418 Predicted transcriptional regulator [Transcription]; Region: COG1959 320388007419 Transcriptional regulator; Region: Rrf2; pfam02082 320388007420 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 320388007421 NADH(P)-binding; Region: NAD_binding_10; pfam13460 320388007422 NAD binding site [chemical binding]; other site 320388007423 putative active site [active] 320388007424 substrate binding site [chemical binding]; other site 320388007425 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 320388007426 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388007427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388007428 putative DNA binding site [nucleotide binding]; other site 320388007429 putative Zn2+ binding site [ion binding]; other site 320388007430 AsnC family; Region: AsnC_trans_reg; pfam01037 320388007431 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320388007432 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 320388007433 Walker A/P-loop; other site 320388007434 ATP binding site [chemical binding]; other site 320388007435 Q-loop/lid; other site 320388007436 ABC transporter signature motif; other site 320388007437 Walker B; other site 320388007438 D-loop; other site 320388007439 H-loop/switch region; other site 320388007440 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 320388007441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388007442 dimer interface [polypeptide binding]; other site 320388007443 conserved gate region; other site 320388007444 putative PBP binding loops; other site 320388007445 ABC-ATPase subunit interface; other site 320388007446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388007447 ABC-ATPase subunit interface; other site 320388007448 putative PBP binding loops; other site 320388007449 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320388007450 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320388007451 putative proline-specific permease; Provisional; Region: proY; PRK10580 320388007452 Predicted membrane protein [Function unknown]; Region: COG1289 320388007453 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 320388007454 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320388007455 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388007456 trimer interface [polypeptide binding]; other site 320388007457 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 320388007458 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 320388007459 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 320388007460 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 320388007461 Family description; Region: UvrD_C_2; pfam13538 320388007462 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 320388007463 AAA domain; Region: AAA_30; pfam13604 320388007464 Family description; Region: UvrD_C_2; pfam13538 320388007465 hypothetical protein; Provisional; Region: PRK09256 320388007466 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 320388007467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320388007468 EamA-like transporter family; Region: EamA; pfam00892 320388007469 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320388007470 EamA-like transporter family; Region: EamA; pfam00892 320388007471 Transposase; Region: HTH_Tnp_1; pfam01527 320388007472 HTH-like domain; Region: HTH_21; pfam13276 320388007473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007474 Integrase core domain; Region: rve; pfam00665 320388007475 Integrase core domain; Region: rve_3; pfam13683 320388007476 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 320388007477 ThiC-associated domain; Region: ThiC-associated; pfam13667 320388007478 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 320388007479 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 320388007480 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 320388007481 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 320388007482 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 320388007483 Moco binding site; other site 320388007484 metal coordination site [ion binding]; other site 320388007485 EamA-like transporter family; Region: EamA; pfam00892 320388007486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007487 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320388007488 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388007489 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388007490 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388007491 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 320388007492 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388007493 active site 320388007494 metal binding site [ion binding]; metal-binding site 320388007495 hexamer interface [polypeptide binding]; other site 320388007496 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 320388007497 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320388007498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388007499 Walker A/P-loop; other site 320388007500 ATP binding site [chemical binding]; other site 320388007501 Q-loop/lid; other site 320388007502 ABC transporter signature motif; other site 320388007503 Walker B; other site 320388007504 D-loop; other site 320388007505 H-loop/switch region; other site 320388007506 TOBE domain; Region: TOBE_2; pfam08402 320388007507 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320388007508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388007509 putative PBP binding loops; other site 320388007510 ABC-ATPase subunit interface; other site 320388007511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 320388007512 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320388007513 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320388007514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320388007515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320388007516 DNA binding site [nucleotide binding] 320388007517 domain linker motif; other site 320388007518 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 320388007519 putative dimerization interface [polypeptide binding]; other site 320388007520 putative ligand binding site [chemical binding]; other site 320388007521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388007522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388007523 metal binding site [ion binding]; metal-binding site 320388007524 active site 320388007525 I-site; other site 320388007526 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 320388007527 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 320388007528 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 320388007529 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 320388007530 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388007531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388007532 DNA-binding site [nucleotide binding]; DNA binding site 320388007533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007535 homodimer interface [polypeptide binding]; other site 320388007536 catalytic residue [active] 320388007537 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388007538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388007539 putative DNA binding site [nucleotide binding]; other site 320388007540 putative Zn2+ binding site [ion binding]; other site 320388007541 AsnC family; Region: AsnC_trans_reg; pfam01037 320388007542 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320388007543 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320388007544 glutaminase active site [active] 320388007545 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320388007546 dimer interface [polypeptide binding]; other site 320388007547 active site 320388007548 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320388007549 dimer interface [polypeptide binding]; other site 320388007550 active site 320388007551 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 320388007552 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 320388007553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388007554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388007555 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320388007556 putative effector binding pocket; other site 320388007557 putative dimerization interface [polypeptide binding]; other site 320388007558 short chain dehydrogenase; Provisional; Region: PRK12744 320388007559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388007560 NAD(P) binding site [chemical binding]; other site 320388007561 active site 320388007562 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 320388007563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 320388007564 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 320388007565 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 320388007566 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388007567 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388007568 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 320388007569 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388007570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388007571 DNA-binding site [nucleotide binding]; DNA binding site 320388007572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007574 homodimer interface [polypeptide binding]; other site 320388007575 catalytic residue [active] 320388007576 GSCFA family; Region: GSCFA; pfam08885 320388007577 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320388007578 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320388007579 putative dimer interface [polypeptide binding]; other site 320388007580 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320388007581 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320388007582 putative dimer interface [polypeptide binding]; other site 320388007583 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 320388007584 active site 320388007585 substrate-binding site [chemical binding]; other site 320388007586 metal-binding site [ion binding] 320388007587 GTP binding site [chemical binding]; other site 320388007588 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 320388007589 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388007590 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388007591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388007592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388007593 LysR substrate binding domain; Region: LysR_substrate; pfam03466 320388007594 dimerization interface [polypeptide binding]; other site 320388007595 Malonate transporter MadL subunit; Region: MadL; cl04273 320388007596 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 320388007597 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 320388007598 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 320388007599 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 320388007600 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 320388007601 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 320388007602 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 320388007603 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 320388007604 Acyl transferase domain; Region: Acyl_transf_1; cl08282 320388007605 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320388007606 putative active site [active] 320388007607 catalytic site [active] 320388007608 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 320388007609 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320388007610 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320388007611 GSH binding site (G-site) [chemical binding]; other site 320388007612 C-terminal domain interface [polypeptide binding]; other site 320388007613 HTH-like domain; Region: HTH_21; pfam13276 320388007614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007615 Integrase core domain; Region: rve; pfam00665 320388007616 Integrase core domain; Region: rve_3; pfam13683 320388007617 Transposase; Region: HTH_Tnp_1; pfam01527 320388007618 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 320388007619 N-terminal domain interface [polypeptide binding]; other site 320388007620 proline/glycine betaine transporter; Provisional; Region: PRK10642 320388007621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007622 putative substrate translocation pore; other site 320388007623 hypothetical protein; Provisional; Region: PRK02237 320388007624 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 320388007625 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 320388007626 active site 320388007627 catalytic site [active] 320388007628 substrate binding site [chemical binding]; other site 320388007629 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 320388007630 RNA/DNA hybrid binding site [nucleotide binding]; other site 320388007631 active site 320388007632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388007633 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 320388007634 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 320388007635 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320388007636 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320388007637 catalytic residue [active] 320388007638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 320388007639 Lysin motif; Region: LysM; smart00257 320388007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388007642 putative substrate translocation pore; other site 320388007643 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320388007644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388007645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388007646 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 320388007647 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 320388007648 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 320388007649 catalytic site [active] 320388007650 subunit interface [polypeptide binding]; other site 320388007651 leucine export protein LeuE; Provisional; Region: PRK10958 320388007652 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 320388007653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320388007654 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 320388007655 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 320388007656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320388007657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388007658 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 320388007659 IMP binding site; other site 320388007660 dimer interface [polypeptide binding]; other site 320388007661 interdomain contacts; other site 320388007662 partial ornithine binding site; other site 320388007663 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 320388007664 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 320388007665 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320388007666 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 320388007667 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 320388007668 FtsJ-like methyltransferase; Region: FtsJ; cl17430 320388007669 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 320388007670 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 320388007671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388007672 Walker A motif; other site 320388007673 ATP binding site [chemical binding]; other site 320388007674 Walker B motif; other site 320388007675 arginine finger; other site 320388007676 Peptidase family M41; Region: Peptidase_M41; pfam01434 320388007677 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 320388007678 dihydropteroate synthase; Region: DHPS; TIGR01496 320388007679 substrate binding pocket [chemical binding]; other site 320388007680 dimer interface [polypeptide binding]; other site 320388007681 inhibitor binding site; inhibition site 320388007682 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 320388007683 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 320388007684 active site 320388007685 substrate binding site [chemical binding]; other site 320388007686 metal binding site [ion binding]; metal-binding site 320388007687 PBP superfamily domain; Region: PBP_like_2; cl17296 320388007688 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 320388007689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388007690 dimer interface [polypeptide binding]; other site 320388007691 conserved gate region; other site 320388007692 putative PBP binding loops; other site 320388007693 ABC-ATPase subunit interface; other site 320388007694 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 320388007695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388007696 dimer interface [polypeptide binding]; other site 320388007697 conserved gate region; other site 320388007698 putative PBP binding loops; other site 320388007699 ABC-ATPase subunit interface; other site 320388007700 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 320388007701 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 320388007702 Walker A/P-loop; other site 320388007703 ATP binding site [chemical binding]; other site 320388007704 Q-loop/lid; other site 320388007705 ABC transporter signature motif; other site 320388007706 Walker B; other site 320388007707 D-loop; other site 320388007708 H-loop/switch region; other site 320388007709 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 320388007710 PhoU domain; Region: PhoU; pfam01895 320388007711 PhoU domain; Region: PhoU; pfam01895 320388007712 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 320388007713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007714 active site 320388007715 phosphorylation site [posttranslational modification] 320388007716 intermolecular recognition site; other site 320388007717 dimerization interface [polypeptide binding]; other site 320388007718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388007719 DNA binding site [nucleotide binding] 320388007720 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320388007721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388007722 dimer interface [polypeptide binding]; other site 320388007723 phosphorylation site [posttranslational modification] 320388007724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388007725 ATP binding site [chemical binding]; other site 320388007726 Mg2+ binding site [ion binding]; other site 320388007727 G-X-G motif; other site 320388007728 polyphosphate kinase; Provisional; Region: PRK05443 320388007729 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 320388007730 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 320388007731 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320388007732 putative active site [active] 320388007733 catalytic site [active] 320388007734 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 320388007735 putative domain interface [polypeptide binding]; other site 320388007736 putative active site [active] 320388007737 catalytic site [active] 320388007738 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 320388007739 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 320388007740 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 320388007741 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 320388007742 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 320388007743 catalytic core [active] 320388007744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 320388007745 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 320388007746 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 320388007747 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 320388007748 active site 320388007749 acyl-activating enzyme (AAE) consensus motif; other site 320388007750 putative CoA binding site [chemical binding]; other site 320388007751 AMP binding site [chemical binding]; other site 320388007752 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320388007753 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 320388007754 Peptidase family M23; Region: Peptidase_M23; pfam01551 320388007755 Transposase; Region: HTH_Tnp_1; pfam01527 320388007756 HTH-like domain; Region: HTH_21; pfam13276 320388007757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007758 Integrase core domain; Region: rve; pfam00665 320388007759 Integrase core domain; Region: rve_3; pfam13683 320388007760 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320388007761 PAAR motif; Region: PAAR_motif; pfam05488 320388007762 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320388007763 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320388007764 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320388007765 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 320388007766 Leucine carboxyl methyltransferase; Region: LCM; cl01306 320388007767 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320388007768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388007769 DNA-binding site [nucleotide binding]; DNA binding site 320388007770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388007771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388007772 homodimer interface [polypeptide binding]; other site 320388007773 catalytic residue [active] 320388007774 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 320388007775 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 320388007776 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 320388007777 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 320388007778 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 320388007779 active site 320388007780 catalytic site [active] 320388007781 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 320388007782 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 320388007783 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 320388007784 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 320388007785 catalytic site [active] 320388007786 active site 320388007787 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 320388007788 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 320388007789 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 320388007790 active site 320388007791 catalytic site [active] 320388007792 glycogen branching enzyme; Provisional; Region: PRK05402 320388007793 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 320388007794 active site 320388007795 catalytic site [active] 320388007796 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 320388007797 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 320388007798 trehalose synthase; Region: treS_nterm; TIGR02456 320388007799 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 320388007800 active site 320388007801 catalytic site [active] 320388007802 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 320388007803 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 320388007804 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 320388007805 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 320388007806 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 320388007807 active site 320388007808 homodimer interface [polypeptide binding]; other site 320388007809 catalytic site [active] 320388007810 acceptor binding site [chemical binding]; other site 320388007811 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 320388007812 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 320388007813 Interdomain contacts; other site 320388007814 Cytokine receptor motif; other site 320388007815 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 320388007816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388007817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388007818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388007819 dimerization interface [polypeptide binding]; other site 320388007820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388007821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007822 active site 320388007823 phosphorylation site [posttranslational modification] 320388007824 intermolecular recognition site; other site 320388007825 dimerization interface [polypeptide binding]; other site 320388007826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388007827 DNA binding site [nucleotide binding] 320388007828 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 320388007829 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 320388007830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388007831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007832 active site 320388007833 phosphorylation site [posttranslational modification] 320388007834 intermolecular recognition site; other site 320388007835 dimerization interface [polypeptide binding]; other site 320388007836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388007837 DNA binding site [nucleotide binding] 320388007838 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 320388007839 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320388007840 trimer interface [polypeptide binding]; other site 320388007841 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 320388007842 trimer interface [polypeptide binding]; other site 320388007843 YadA-like C-terminal region; Region: YadA; pfam03895 320388007844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388007845 ligand binding site [chemical binding]; other site 320388007846 TPR repeat; Region: TPR_11; pfam13414 320388007847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388007848 binding surface 320388007849 TPR motif; other site 320388007850 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 320388007851 H-NS histone family; Region: Histone_HNS; pfam00816 320388007852 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388007853 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320388007854 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320388007855 Cu(I) binding site [ion binding]; other site 320388007856 Ricin-type beta-trefoil; Region: RICIN; smart00458 320388007857 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320388007858 putative sugar binding sites [chemical binding]; other site 320388007859 Q-X-W motif; other site 320388007860 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 320388007861 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 320388007862 Galactose oxidase, central domain; Region: Kelch_3; cl02701 320388007863 Kelch motif; Region: Kelch_6; pfam13964 320388007864 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 320388007865 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320388007866 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320388007867 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320388007868 PAAR motif; Region: PAAR_motif; pfam05488 320388007869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 320388007870 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320388007871 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320388007872 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320388007873 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 320388007874 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320388007875 HTH-like domain; Region: HTH_21; pfam13276 320388007876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007877 Integrase core domain; Region: rve; pfam00665 320388007878 Integrase core domain; Region: rve_3; pfam13683 320388007879 Transposase; Region: HTH_Tnp_1; pfam01527 320388007880 manganese transport protein MntH; Reviewed; Region: PRK00701 320388007881 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320388007882 H-NS histone family; Region: Histone_HNS; pfam00816 320388007883 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388007884 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320388007885 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388007886 active site 320388007887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007888 putative substrate translocation pore; other site 320388007889 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320388007890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388007891 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320388007892 dimerization interface [polypeptide binding]; other site 320388007893 substrate binding pocket [chemical binding]; other site 320388007894 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388007895 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388007896 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388007897 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320388007898 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320388007899 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320388007900 PapC N-terminal domain; Region: PapC_N; pfam13954 320388007901 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320388007902 PapC C-terminal domain; Region: PapC_C; pfam13953 320388007903 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388007904 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388007905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388007906 dimer interface [polypeptide binding]; other site 320388007907 phosphorylation site [posttranslational modification] 320388007908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388007909 ATP binding site [chemical binding]; other site 320388007910 Mg2+ binding site [ion binding]; other site 320388007911 G-X-G motif; other site 320388007912 Response regulator receiver domain; Region: Response_reg; pfam00072 320388007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007914 active site 320388007915 phosphorylation site [posttranslational modification] 320388007916 intermolecular recognition site; other site 320388007917 dimerization interface [polypeptide binding]; other site 320388007918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388007919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388007920 active site 320388007921 phosphorylation site [posttranslational modification] 320388007922 intermolecular recognition site; other site 320388007923 dimerization interface [polypeptide binding]; other site 320388007924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388007925 DNA binding residues [nucleotide binding] 320388007926 dimerization interface [polypeptide binding]; other site 320388007927 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388007928 Outer membrane efflux protein; Region: OEP; pfam02321 320388007929 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388007930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007931 putative substrate translocation pore; other site 320388007932 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 320388007933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388007934 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388007935 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 320388007936 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 320388007937 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 320388007938 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 320388007939 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 320388007940 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 320388007941 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 320388007942 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 320388007943 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320388007944 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 320388007945 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 320388007946 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 320388007947 nudix motif; other site 320388007948 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 320388007949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388007950 active site 320388007951 HIGH motif; other site 320388007952 nucleotide binding site [chemical binding]; other site 320388007953 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 320388007954 KMSKS motif; other site 320388007955 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 320388007956 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388007957 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388007958 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 320388007959 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 320388007960 motif 1; other site 320388007961 active site 320388007962 motif 2; other site 320388007963 motif 3; other site 320388007964 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320388007965 DHHA1 domain; Region: DHHA1; pfam02272 320388007966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388007967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388007968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388007969 dimerization interface [polypeptide binding]; other site 320388007970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388007971 Transposase; Region: HTH_Tnp_1; pfam01527 320388007972 HTH-like domain; Region: HTH_21; pfam13276 320388007973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388007974 Integrase core domain; Region: rve; pfam00665 320388007975 Integrase core domain; Region: rve_3; pfam13683 320388007976 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320388007977 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388007978 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 320388007979 nudix motif; other site 320388007980 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 320388007981 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 320388007982 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 320388007983 putative active site [active] 320388007984 metal binding site [ion binding]; metal-binding site 320388007985 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320388007986 active site 320388007987 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388007988 TM-ABC transporter signature motif; other site 320388007989 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388007990 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388007991 TM-ABC transporter signature motif; other site 320388007992 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388007993 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388007994 Walker A/P-loop; other site 320388007995 ATP binding site [chemical binding]; other site 320388007996 Q-loop/lid; other site 320388007997 ABC transporter signature motif; other site 320388007998 Walker B; other site 320388007999 D-loop; other site 320388008000 H-loop/switch region; other site 320388008001 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388008002 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388008003 Walker A/P-loop; other site 320388008004 ATP binding site [chemical binding]; other site 320388008005 Q-loop/lid; other site 320388008006 ABC transporter signature motif; other site 320388008007 Walker B; other site 320388008008 D-loop; other site 320388008009 H-loop/switch region; other site 320388008010 KduI/IolB family; Region: KduI; pfam04962 320388008011 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 320388008012 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 320388008013 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388008014 PYR/PP interface [polypeptide binding]; other site 320388008015 dimer interface [polypeptide binding]; other site 320388008016 TPP binding site [chemical binding]; other site 320388008017 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388008018 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320388008019 TPP-binding site [chemical binding]; other site 320388008020 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388008021 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320388008022 substrate binding site [chemical binding]; other site 320388008023 ATP binding site [chemical binding]; other site 320388008024 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 320388008025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 320388008026 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388008027 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320388008028 Walker A/P-loop; other site 320388008029 ATP binding site [chemical binding]; other site 320388008030 Q-loop/lid; other site 320388008031 ABC transporter signature motif; other site 320388008032 Walker B; other site 320388008033 D-loop; other site 320388008034 H-loop/switch region; other site 320388008035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388008036 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320388008037 TM-ABC transporter signature motif; other site 320388008038 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 320388008039 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320388008040 putative ligand binding site [chemical binding]; other site 320388008041 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388008042 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388008043 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320388008044 putative active site [active] 320388008045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320388008046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320388008047 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320388008048 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320388008049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320388008050 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 320388008051 CPxP motif; other site 320388008052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388008054 active site 320388008055 phosphorylation site [posttranslational modification] 320388008056 intermolecular recognition site; other site 320388008057 dimerization interface [polypeptide binding]; other site 320388008058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388008059 DNA binding site [nucleotide binding] 320388008060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 320388008061 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320388008062 FecR protein; Region: FecR; pfam04773 320388008063 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 320388008064 CHASE2 domain; Region: CHASE2; pfam05226 320388008065 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320388008066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388008067 dimer interface [polypeptide binding]; other site 320388008068 phosphorylation site [posttranslational modification] 320388008069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388008070 ATP binding site [chemical binding]; other site 320388008071 Mg2+ binding site [ion binding]; other site 320388008072 G-X-G motif; other site 320388008073 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 320388008074 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 320388008075 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 320388008076 active site 320388008077 tetramer interface; other site 320388008078 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 320388008079 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 320388008080 HIGH motif; other site 320388008081 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320388008082 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 320388008083 active site 320388008084 KMSKS motif; other site 320388008085 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 320388008086 tRNA binding surface [nucleotide binding]; other site 320388008087 anticodon binding site; other site 320388008088 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 320388008089 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 320388008090 Part of AAA domain; Region: AAA_19; pfam13245 320388008091 Family description; Region: UvrD_C_2; pfam13538 320388008092 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 320388008093 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 320388008094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388008096 putative substrate translocation pore; other site 320388008097 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388008098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388008099 dimer interface [polypeptide binding]; other site 320388008100 putative CheW interface [polypeptide binding]; other site 320388008101 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 320388008102 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388008103 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388008104 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 320388008105 Fusaric acid resistance protein family; Region: FUSC; pfam04632 320388008106 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320388008107 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388008108 transcriptional regulator; Provisional; Region: PRK10632 320388008109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388008110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388008111 putative effector binding pocket; other site 320388008112 dimerization interface [polypeptide binding]; other site 320388008113 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388008114 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320388008115 active site 320388008116 metal binding site [ion binding]; metal-binding site 320388008117 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320388008118 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388008119 FAD binding domain; Region: FAD_binding_4; pfam01565 320388008120 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 320388008121 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 320388008122 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388008123 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 320388008124 Protein of unknown function (DUF962); Region: DUF962; cl01879 320388008125 FOG: CBS domain [General function prediction only]; Region: COG0517 320388008126 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 320388008127 lysophospholipid transporter LplT; Provisional; Region: PRK11195 320388008128 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320388008129 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320388008130 putative acyl-acceptor binding pocket; other site 320388008131 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 320388008132 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 320388008133 Tetramer interface [polypeptide binding]; other site 320388008134 active site 320388008135 FMN-binding site [chemical binding]; other site 320388008136 HTH-like domain; Region: HTH_21; pfam13276 320388008137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008138 Integrase core domain; Region: rve; pfam00665 320388008139 Integrase core domain; Region: rve_3; pfam13683 320388008140 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320388008141 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320388008142 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320388008143 active site 320388008144 HTH-like domain; Region: HTH_21; pfam13276 320388008145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008146 Integrase core domain; Region: rve; pfam00665 320388008147 Integrase core domain; Region: rve_3; pfam13683 320388008148 Transposase; Region: HTH_Tnp_1; pfam01527 320388008149 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 320388008150 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 320388008151 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 320388008152 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 320388008153 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320388008154 Predicted ATPase [General function prediction only]; Region: COG1485 320388008155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388008156 Walker B; other site 320388008157 D-loop; other site 320388008158 H-loop/switch region; other site 320388008159 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 320388008160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388008161 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320388008162 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 320388008163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320388008164 E3 interaction surface; other site 320388008165 lipoyl attachment site [posttranslational modification]; other site 320388008166 e3 binding domain; Region: E3_binding; pfam02817 320388008167 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320388008168 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 320388008169 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 320388008170 TPP-binding site [chemical binding]; other site 320388008171 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 320388008172 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 320388008173 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 320388008174 G1 box; other site 320388008175 putative GEF interaction site [polypeptide binding]; other site 320388008176 GTP/Mg2+ binding site [chemical binding]; other site 320388008177 Switch I region; other site 320388008178 G2 box; other site 320388008179 G3 box; other site 320388008180 Switch II region; other site 320388008181 G4 box; other site 320388008182 G5 box; other site 320388008183 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 320388008184 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 320388008185 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320388008186 MarR family; Region: MarR_2; pfam12802 320388008187 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388008188 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 320388008189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388008190 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388008191 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388008192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008193 putative substrate translocation pore; other site 320388008194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008195 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 320388008196 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 320388008197 RNA binding site [nucleotide binding]; other site 320388008198 active site 320388008199 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 320388008200 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 320388008201 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 320388008202 translation initiation factor IF-2; Region: IF-2; TIGR00487 320388008203 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 320388008204 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 320388008205 G1 box; other site 320388008206 putative GEF interaction site [polypeptide binding]; other site 320388008207 GTP/Mg2+ binding site [chemical binding]; other site 320388008208 Switch I region; other site 320388008209 G2 box; other site 320388008210 G3 box; other site 320388008211 Switch II region; other site 320388008212 G4 box; other site 320388008213 G5 box; other site 320388008214 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 320388008215 Translation-initiation factor 2; Region: IF-2; pfam11987 320388008216 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 320388008217 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 320388008218 NusA N-terminal domain; Region: NusA_N; pfam08529 320388008219 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 320388008220 RNA binding site [nucleotide binding]; other site 320388008221 homodimer interface [polypeptide binding]; other site 320388008222 NusA-like KH domain; Region: KH_5; pfam13184 320388008223 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 320388008224 G-X-X-G motif; other site 320388008225 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 320388008226 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 320388008227 ribosome maturation protein RimP; Reviewed; Region: PRK00092 320388008228 Sm and related proteins; Region: Sm_like; cl00259 320388008229 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 320388008230 putative oligomer interface [polypeptide binding]; other site 320388008231 putative RNA binding site [nucleotide binding]; other site 320388008232 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320388008233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388008234 RNA binding surface [nucleotide binding]; other site 320388008235 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 320388008236 probable active site [active] 320388008237 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 320388008238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388008239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388008240 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 320388008241 putative dimerization interface [polypeptide binding]; other site 320388008242 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320388008243 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 320388008244 Uncharacterized conserved protein [Function unknown]; Region: COG1434 320388008245 putative active site [active] 320388008246 outer membrane protein A; Reviewed; Region: PRK10808 320388008247 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 320388008248 Transposase; Region: HTH_Tnp_1; pfam01527 320388008249 HTH-like domain; Region: HTH_21; pfam13276 320388008250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008251 Integrase core domain; Region: rve; pfam00665 320388008252 Integrase core domain; Region: rve_3; pfam13683 320388008253 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 320388008254 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 320388008255 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 320388008256 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 320388008257 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 320388008258 HTH-like domain; Region: HTH_21; pfam13276 320388008259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008260 Integrase core domain; Region: rve; pfam00665 320388008261 Integrase core domain; Region: rve_3; pfam13683 320388008262 Transposase; Region: HTH_Tnp_1; pfam01527 320388008263 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 320388008264 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 320388008265 DNA binding residues [nucleotide binding] 320388008266 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320388008267 IHF dimer interface [polypeptide binding]; other site 320388008268 IHF - DNA interface [nucleotide binding]; other site 320388008269 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 320388008270 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 320388008271 putative tRNA-binding site [nucleotide binding]; other site 320388008272 B3/4 domain; Region: B3_4; pfam03483 320388008273 tRNA synthetase B5 domain; Region: B5; smart00874 320388008274 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 320388008275 dimer interface [polypeptide binding]; other site 320388008276 motif 1; other site 320388008277 motif 3; other site 320388008278 motif 2; other site 320388008279 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 320388008280 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 320388008281 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 320388008282 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 320388008283 dimer interface [polypeptide binding]; other site 320388008284 motif 1; other site 320388008285 active site 320388008286 motif 2; other site 320388008287 motif 3; other site 320388008288 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 320388008289 23S rRNA binding site [nucleotide binding]; other site 320388008290 L21 binding site [polypeptide binding]; other site 320388008291 L13 binding site [polypeptide binding]; other site 320388008292 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 320388008293 translation initiation factor IF-3; Region: infC; TIGR00168 320388008294 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 320388008295 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 320388008296 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 320388008297 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 320388008298 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320388008299 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 320388008300 active site 320388008301 dimer interface [polypeptide binding]; other site 320388008302 motif 1; other site 320388008303 motif 2; other site 320388008304 motif 3; other site 320388008305 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 320388008306 anticodon binding site; other site 320388008307 HD domain; Region: HD_4; pfam13328 320388008308 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 320388008309 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 320388008310 synthetase active site [active] 320388008311 NTP binding site [chemical binding]; other site 320388008312 metal binding site [ion binding]; metal-binding site 320388008313 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 320388008314 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 320388008315 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 320388008316 homotrimer interaction site [polypeptide binding]; other site 320388008317 putative active site [active] 320388008318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388008319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320388008320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388008321 transcriptional activator TtdR; Provisional; Region: PRK09801 320388008322 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388008323 putative effector binding pocket; other site 320388008324 dimerization interface [polypeptide binding]; other site 320388008325 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 320388008326 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 320388008327 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 320388008328 short chain dehydrogenase; Provisional; Region: PRK07041 320388008329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388008330 NAD(P) binding site [chemical binding]; other site 320388008331 active site 320388008332 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 320388008333 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 320388008334 PAS domain; Region: PAS_9; pfam13426 320388008335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388008336 putative active site [active] 320388008337 heme pocket [chemical binding]; other site 320388008338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388008339 DNA binding residues [nucleotide binding] 320388008340 dimerization interface [polypeptide binding]; other site 320388008341 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 320388008342 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320388008343 active site 320388008344 short chain dehydrogenase; Provisional; Region: PRK06949 320388008345 classical (c) SDRs; Region: SDR_c; cd05233 320388008346 NAD(P) binding site [chemical binding]; other site 320388008347 active site 320388008348 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 320388008349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320388008350 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 320388008351 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 320388008352 Transposase; Region: HTH_Tnp_1; pfam01527 320388008353 HTH-like domain; Region: HTH_21; pfam13276 320388008354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008355 Integrase core domain; Region: rve; pfam00665 320388008356 Integrase core domain; Region: rve_3; pfam13683 320388008357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388008358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388008359 catalytic residue [active] 320388008360 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388008361 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388008362 Cupin-like domain; Region: Cupin_8; pfam13621 320388008363 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320388008364 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388008365 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388008366 trimer interface [polypeptide binding]; other site 320388008367 eyelet of channel; other site 320388008368 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388008369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388008370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388008371 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388008372 EamA-like transporter family; Region: EamA; pfam00892 320388008373 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 320388008374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388008375 dimer interface [polypeptide binding]; other site 320388008376 putative CheW interface [polypeptide binding]; other site 320388008377 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 320388008378 AMP-binding domain protein; Validated; Region: PRK07529 320388008379 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388008380 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 320388008381 acyl-activating enzyme (AAE) consensus motif; other site 320388008382 putative AMP binding site [chemical binding]; other site 320388008383 putative active site [active] 320388008384 putative CoA binding site [chemical binding]; other site 320388008385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008386 putative substrate translocation pore; other site 320388008387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388008388 S-adenosylmethionine binding site [chemical binding]; other site 320388008389 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 320388008390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008391 dimer interface [polypeptide binding]; other site 320388008392 conserved gate region; other site 320388008393 putative PBP binding loops; other site 320388008394 ABC-ATPase subunit interface; other site 320388008395 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 320388008396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388008397 Walker A/P-loop; other site 320388008398 ATP binding site [chemical binding]; other site 320388008399 Q-loop/lid; other site 320388008400 ABC transporter signature motif; other site 320388008401 Walker B; other site 320388008402 D-loop; other site 320388008403 H-loop/switch region; other site 320388008404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008405 ABC-ATPase subunit interface; other site 320388008406 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 320388008407 arginine deiminase; Provisional; Region: PRK01388 320388008408 ornithine carbamoyltransferase; Validated; Region: PRK02102 320388008409 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320388008410 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320388008411 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 320388008412 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 320388008413 putative substrate binding site [chemical binding]; other site 320388008414 nucleotide binding site [chemical binding]; other site 320388008415 nucleotide binding site [chemical binding]; other site 320388008416 homodimer interface [polypeptide binding]; other site 320388008417 short chain dehydrogenase; Provisional; Region: PRK09291 320388008418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388008419 NAD(P) binding site [chemical binding]; other site 320388008420 active site 320388008421 Domain of unknown function (DUF336); Region: DUF336; pfam03928 320388008422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388008423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388008424 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 320388008425 putative effector binding pocket; other site 320388008426 putative dimerization interface [polypeptide binding]; other site 320388008427 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320388008428 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320388008429 C-terminal domain interface [polypeptide binding]; other site 320388008430 GSH binding site (G-site) [chemical binding]; other site 320388008431 dimer interface [polypeptide binding]; other site 320388008432 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 320388008433 dimer interface [polypeptide binding]; other site 320388008434 N-terminal domain interface [polypeptide binding]; other site 320388008435 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320388008436 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 320388008437 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320388008438 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320388008439 dimerization interface [polypeptide binding]; other site 320388008440 ligand binding site [chemical binding]; other site 320388008441 MarR family; Region: MarR_2; cl17246 320388008442 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320388008443 putative cyanate transporter; Provisional; Region: cynX; PRK09705 320388008444 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 320388008445 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 320388008446 active site 320388008447 SAM binding site [chemical binding]; other site 320388008448 homodimer interface [polypeptide binding]; other site 320388008449 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 320388008450 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 320388008451 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 320388008452 active site 320388008453 putative homodimer interface [polypeptide binding]; other site 320388008454 SAM binding site [chemical binding]; other site 320388008455 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 320388008456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388008457 S-adenosylmethionine binding site [chemical binding]; other site 320388008458 precorrin-3B synthase; Region: CobG; TIGR02435 320388008459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388008460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388008461 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 320388008462 Precorrin-8X methylmutase; Region: CbiC; pfam02570 320388008463 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 320388008464 active site 320388008465 SAM binding site [chemical binding]; other site 320388008466 homodimer interface [polypeptide binding]; other site 320388008467 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 320388008468 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 320388008469 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 320388008470 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 320388008471 active site 320388008472 SAM binding site [chemical binding]; other site 320388008473 homodimer interface [polypeptide binding]; other site 320388008474 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 320388008475 active site 320388008476 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 320388008477 aromatic chitin/cellulose binding site residues [chemical binding]; other site 320388008478 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 320388008479 aromatic chitin/cellulose binding site residues [chemical binding]; other site 320388008480 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 320388008481 Serine hydrolase (FSH1); Region: FSH1; pfam03959 320388008482 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 320388008483 metal ion-dependent adhesion site (MIDAS); other site 320388008484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388008485 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320388008486 Walker A motif; other site 320388008487 ATP binding site [chemical binding]; other site 320388008488 Walker B motif; other site 320388008489 arginine finger; other site 320388008490 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 320388008491 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 320388008492 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 320388008493 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 320388008494 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 320388008495 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 320388008496 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 320388008497 High-affinity nickel-transport protein; Region: NicO; cl00964 320388008498 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 320388008499 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 320388008500 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 320388008501 homodimer interface [polypeptide binding]; other site 320388008502 Walker A motif; other site 320388008503 ATP binding site [chemical binding]; other site 320388008504 hydroxycobalamin binding site [chemical binding]; other site 320388008505 Walker B motif; other site 320388008506 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 320388008507 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 320388008508 catalytic triad [active] 320388008509 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 320388008510 catalytic site [active] 320388008511 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 320388008512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388008513 N-terminal plug; other site 320388008514 ligand-binding site [chemical binding]; other site 320388008515 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 320388008516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388008517 Condensation domain; Region: Condensation; pfam00668 320388008518 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320388008519 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388008520 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320388008521 acyl-activating enzyme (AAE) consensus motif; other site 320388008522 AMP binding site [chemical binding]; other site 320388008523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388008524 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320388008525 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388008526 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320388008527 acyl-activating enzyme (AAE) consensus motif; other site 320388008528 AMP binding site [chemical binding]; other site 320388008529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388008530 Condensation domain; Region: Condensation; pfam00668 320388008531 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320388008532 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320388008533 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388008534 acyl-activating enzyme (AAE) consensus motif; other site 320388008535 AMP binding site [chemical binding]; other site 320388008536 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388008537 Condensation domain; Region: Condensation; pfam00668 320388008538 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 320388008539 Condensation domain; Region: Condensation; pfam00668 320388008540 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320388008541 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388008542 acyl-activating enzyme (AAE) consensus motif; other site 320388008543 AMP binding site [chemical binding]; other site 320388008544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388008545 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 320388008546 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 320388008547 Walker A/P-loop; other site 320388008548 ATP binding site [chemical binding]; other site 320388008549 Q-loop/lid; other site 320388008550 ABC transporter signature motif; other site 320388008551 Walker B; other site 320388008552 D-loop; other site 320388008553 H-loop/switch region; other site 320388008554 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 320388008555 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 320388008556 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 320388008557 siderophore binding site; other site 320388008558 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 320388008559 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 320388008560 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 320388008561 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 320388008562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 320388008563 dimer interface [polypeptide binding]; other site 320388008564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320388008565 ABC-ATPase subunit interface; other site 320388008566 dimer interface [polypeptide binding]; other site 320388008567 putative PBP binding regions; other site 320388008568 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320388008569 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320388008570 Walker A/P-loop; other site 320388008571 ATP binding site [chemical binding]; other site 320388008572 Q-loop/lid; other site 320388008573 ABC transporter signature motif; other site 320388008574 Walker B; other site 320388008575 D-loop; other site 320388008576 H-loop/switch region; other site 320388008577 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320388008578 MbtH-like protein; Region: MbtH; cl01279 320388008579 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 320388008580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388008581 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 320388008582 DNA binding residues [nucleotide binding] 320388008583 short chain dehydrogenase; Provisional; Region: PRK07060 320388008584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388008585 NAD(P) binding site [chemical binding]; other site 320388008586 active site 320388008587 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 320388008588 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 320388008589 N- and C-terminal domain interface [polypeptide binding]; other site 320388008590 putative active site [active] 320388008591 MgATP binding site [chemical binding]; other site 320388008592 catalytic site [active] 320388008593 metal binding site [ion binding]; metal-binding site 320388008594 putative xylulose binding site [chemical binding]; other site 320388008595 putative homodimer interface [polypeptide binding]; other site 320388008596 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320388008597 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320388008598 NAD(P) binding site [chemical binding]; other site 320388008599 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 320388008600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388008601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320388008602 TM-ABC transporter signature motif; other site 320388008603 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320388008604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320388008605 Walker A/P-loop; other site 320388008606 ATP binding site [chemical binding]; other site 320388008607 Q-loop/lid; other site 320388008608 ABC transporter signature motif; other site 320388008609 Walker B; other site 320388008610 D-loop; other site 320388008611 H-loop/switch region; other site 320388008612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320388008613 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 320388008614 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320388008615 putative ligand binding site [chemical binding]; other site 320388008616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388008617 Helix-turn-helix domain; Region: HTH_18; pfam12833 320388008618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388008619 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 320388008620 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 320388008621 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320388008622 Ligand Binding Site [chemical binding]; other site 320388008623 Molecular Tunnel; other site 320388008624 HTH-like domain; Region: HTH_21; pfam13276 320388008625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008626 Integrase core domain; Region: rve; pfam00665 320388008627 Integrase core domain; Region: rve_3; pfam13683 320388008628 Transposase; Region: HTH_Tnp_1; pfam01527 320388008629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320388008630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388008631 Walker A/P-loop; other site 320388008632 ATP binding site [chemical binding]; other site 320388008633 Q-loop/lid; other site 320388008634 ABC transporter signature motif; other site 320388008635 Walker B; other site 320388008636 D-loop; other site 320388008637 H-loop/switch region; other site 320388008638 Fimbrial protein; Region: Fimbrial; pfam00419 320388008639 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320388008640 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320388008641 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 320388008642 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320388008643 PapC N-terminal domain; Region: PapC_N; pfam13954 320388008644 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320388008645 PapC C-terminal domain; Region: PapC_C; pfam13953 320388008646 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320388008647 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320388008648 multidrug efflux protein; Reviewed; Region: PRK09577 320388008649 Protein export membrane protein; Region: SecD_SecF; cl14618 320388008650 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 320388008651 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388008652 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388008653 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 320388008654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388008655 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 320388008656 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 320388008657 Peptidase family M23; Region: Peptidase_M23; pfam01551 320388008658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008659 dimer interface [polypeptide binding]; other site 320388008660 conserved gate region; other site 320388008661 putative PBP binding loops; other site 320388008662 ABC-ATPase subunit interface; other site 320388008663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008664 dimer interface [polypeptide binding]; other site 320388008665 conserved gate region; other site 320388008666 putative PBP binding loops; other site 320388008667 ABC-ATPase subunit interface; other site 320388008668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388008669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388008670 substrate binding pocket [chemical binding]; other site 320388008671 membrane-bound complex binding site; other site 320388008672 hinge residues; other site 320388008673 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320388008674 TadE-like protein; Region: TadE; pfam07811 320388008675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320388008676 binding surface 320388008677 TPR motif; other site 320388008678 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 320388008679 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388008680 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 320388008681 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388008682 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 320388008683 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320388008684 ATP binding site [chemical binding]; other site 320388008685 Walker A motif; other site 320388008686 hexamer interface [polypeptide binding]; other site 320388008687 Walker B motif; other site 320388008688 AAA domain; Region: AAA_31; pfam13614 320388008689 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320388008690 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 320388008691 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 320388008692 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 320388008693 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320388008694 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 320388008695 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320388008696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 320388008697 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320388008698 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320388008699 Walker A/P-loop; other site 320388008700 ATP binding site [chemical binding]; other site 320388008701 Q-loop/lid; other site 320388008702 ABC transporter signature motif; other site 320388008703 Walker B; other site 320388008704 D-loop; other site 320388008705 H-loop/switch region; other site 320388008706 NMT1-like family; Region: NMT1_2; pfam13379 320388008707 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 320388008708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008709 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 320388008710 putative substrate translocation pore; other site 320388008711 SpoVR family protein; Provisional; Region: PRK11767 320388008712 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 320388008713 hypothetical protein; Provisional; Region: PRK05325 320388008714 PrkA family serine protein kinase; Provisional; Region: PRK15455 320388008715 AAA ATPase domain; Region: AAA_16; pfam13191 320388008716 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 320388008717 HTH-like domain; Region: HTH_21; pfam13276 320388008718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008719 Integrase core domain; Region: rve; pfam00665 320388008720 Integrase core domain; Region: rve_3; pfam13683 320388008721 Transposase; Region: HTH_Tnp_1; pfam01527 320388008722 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 320388008723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388008724 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 320388008725 substrate binding site [chemical binding]; other site 320388008726 dimerization interface [polypeptide binding]; other site 320388008727 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 320388008728 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 320388008729 Walker A/P-loop; other site 320388008730 ATP binding site [chemical binding]; other site 320388008731 Q-loop/lid; other site 320388008732 ABC transporter signature motif; other site 320388008733 Walker B; other site 320388008734 D-loop; other site 320388008735 H-loop/switch region; other site 320388008736 TOBE-like domain; Region: TOBE_3; pfam12857 320388008737 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 320388008738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008739 dimer interface [polypeptide binding]; other site 320388008740 conserved gate region; other site 320388008741 putative PBP binding loops; other site 320388008742 ABC-ATPase subunit interface; other site 320388008743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 320388008744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008745 dimer interface [polypeptide binding]; other site 320388008746 conserved gate region; other site 320388008747 putative PBP binding loops; other site 320388008748 ABC-ATPase subunit interface; other site 320388008749 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320388008750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388008751 substrate binding pocket [chemical binding]; other site 320388008752 membrane-bound complex binding site; other site 320388008753 LexA repressor; Validated; Region: PRK00215 320388008754 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 320388008755 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 320388008756 Catalytic site [active] 320388008757 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 320388008758 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320388008759 Ligand Binding Site [chemical binding]; other site 320388008760 nodulation ABC transporter NodI; Provisional; Region: PRK13537 320388008761 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 320388008762 Walker A/P-loop; other site 320388008763 ATP binding site [chemical binding]; other site 320388008764 Q-loop/lid; other site 320388008765 ABC transporter signature motif; other site 320388008766 Walker B; other site 320388008767 D-loop; other site 320388008768 H-loop/switch region; other site 320388008769 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320388008770 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320388008771 Predicted permease; Region: DUF318; cl17795 320388008772 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320388008773 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320388008774 active site 320388008775 catalytic tetrad [active] 320388008776 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320388008777 CoenzymeA binding site [chemical binding]; other site 320388008778 subunit interaction site [polypeptide binding]; other site 320388008779 PHB binding site; other site 320388008780 Predicted transcriptional regulators [Transcription]; Region: COG1733 320388008781 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320388008782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320388008783 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 320388008784 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 320388008785 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 320388008786 FMN binding site [chemical binding]; other site 320388008787 active site 320388008788 catalytic residues [active] 320388008789 substrate binding site [chemical binding]; other site 320388008790 HTH-like domain; Region: HTH_21; pfam13276 320388008791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008792 Integrase core domain; Region: rve; pfam00665 320388008793 Integrase core domain; Region: rve_3; pfam13683 320388008794 Transposase; Region: HTH_Tnp_1; pfam01527 320388008795 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 320388008796 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320388008797 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320388008798 Walker A/P-loop; other site 320388008799 ATP binding site [chemical binding]; other site 320388008800 Q-loop/lid; other site 320388008801 ABC transporter signature motif; other site 320388008802 Walker B; other site 320388008803 D-loop; other site 320388008804 H-loop/switch region; other site 320388008805 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320388008806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008807 dimer interface [polypeptide binding]; other site 320388008808 conserved gate region; other site 320388008809 putative PBP binding loops; other site 320388008810 ABC-ATPase subunit interface; other site 320388008811 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 320388008812 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 320388008813 active site 320388008814 dimer interface [polypeptide binding]; other site 320388008815 non-prolyl cis peptide bond; other site 320388008816 insertion regions; other site 320388008817 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 320388008818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388008819 substrate binding site [chemical binding]; other site 320388008820 oxyanion hole (OAH) forming residues; other site 320388008821 trimer interface [polypeptide binding]; other site 320388008822 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 320388008823 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 320388008824 hypothetical protein; Provisional; Region: PRK02487 320388008825 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 320388008826 nudix motif; other site 320388008827 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 320388008828 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 320388008829 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 320388008830 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 320388008831 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 320388008832 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 320388008833 quinone interaction residues [chemical binding]; other site 320388008834 active site 320388008835 catalytic residues [active] 320388008836 FMN binding site [chemical binding]; other site 320388008837 substrate binding site [chemical binding]; other site 320388008838 cystine transporter subunit; Provisional; Region: PRK11260 320388008839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388008840 substrate binding pocket [chemical binding]; other site 320388008841 membrane-bound complex binding site; other site 320388008842 hinge residues; other site 320388008843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008844 dimer interface [polypeptide binding]; other site 320388008845 conserved gate region; other site 320388008846 putative PBP binding loops; other site 320388008847 ABC-ATPase subunit interface; other site 320388008848 Transposase; Region: HTH_Tnp_1; pfam01527 320388008849 HTH-like domain; Region: HTH_21; pfam13276 320388008850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008851 Integrase core domain; Region: rve; pfam00665 320388008852 Integrase core domain; Region: rve_3; pfam13683 320388008853 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320388008854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320388008855 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320388008856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388008857 DNA-binding site [nucleotide binding]; DNA binding site 320388008858 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 320388008859 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 320388008860 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320388008861 active site 320388008862 dimer interface [polypeptide binding]; other site 320388008863 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320388008864 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320388008865 amidase catalytic site [active] 320388008866 Zn binding residues [ion binding]; other site 320388008867 substrate binding site [chemical binding]; other site 320388008868 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320388008869 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 320388008870 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 320388008871 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 320388008872 ribonuclease R; Region: RNase_R; TIGR02063 320388008873 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 320388008874 RNB domain; Region: RNB; pfam00773 320388008875 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388008876 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 320388008877 RNA binding site [nucleotide binding]; other site 320388008878 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388008879 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388008880 Transposase; Region: HTH_Tnp_1; pfam01527 320388008881 HTH-like domain; Region: HTH_21; pfam13276 320388008882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008883 Integrase core domain; Region: rve; pfam00665 320388008884 Integrase core domain; Region: rve_3; pfam13683 320388008885 Transposase domain (DUF772); Region: DUF772; pfam05598 320388008886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388008887 dimer interface [polypeptide binding]; other site 320388008888 putative CheW interface [polypeptide binding]; other site 320388008889 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320388008890 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 320388008891 metal binding site [ion binding]; metal-binding site 320388008892 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320388008893 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320388008894 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 320388008895 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 320388008896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320388008897 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320388008898 putative sialic acid transporter; Region: 2A0112; TIGR00891 320388008899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388008900 putative substrate translocation pore; other site 320388008901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388008902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388008903 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 320388008904 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 320388008905 acyl-activating enzyme (AAE) consensus motif; other site 320388008906 putative AMP binding site [chemical binding]; other site 320388008907 putative active site [active] 320388008908 putative CoA binding site [chemical binding]; other site 320388008909 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 320388008910 bacterial Hfq-like; Region: Hfq; cd01716 320388008911 hexamer interface [polypeptide binding]; other site 320388008912 Sm1 motif; other site 320388008913 RNA binding site [nucleotide binding]; other site 320388008914 Sm2 motif; other site 320388008915 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 320388008916 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 320388008917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388008918 Walker A motif; other site 320388008919 ATP binding site [chemical binding]; other site 320388008920 Walker B motif; other site 320388008921 arginine finger; other site 320388008922 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388008923 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 320388008924 Predicted membrane protein [Function unknown]; Region: COG4655 320388008925 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 320388008926 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 320388008927 TPR repeat; Region: TPR_11; pfam13414 320388008928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388008929 binding surface 320388008930 TPR motif; other site 320388008931 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 320388008932 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388008933 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 320388008934 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388008935 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 320388008936 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320388008937 ATP binding site [chemical binding]; other site 320388008938 Walker A motif; other site 320388008939 hexamer interface [polypeptide binding]; other site 320388008940 Walker B motif; other site 320388008941 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 320388008942 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320388008943 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 320388008944 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 320388008945 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320388008946 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 320388008947 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320388008948 TadE-like protein; Region: TadE; pfam07811 320388008949 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 320388008950 Transposase; Region: HTH_Tnp_1; pfam01527 320388008951 HTH-like domain; Region: HTH_21; pfam13276 320388008952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388008953 Integrase core domain; Region: rve; pfam00665 320388008954 Integrase core domain; Region: rve_3; pfam13683 320388008955 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320388008956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008957 dimer interface [polypeptide binding]; other site 320388008958 conserved gate region; other site 320388008959 putative PBP binding loops; other site 320388008960 ABC-ATPase subunit interface; other site 320388008961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388008962 dimer interface [polypeptide binding]; other site 320388008963 conserved gate region; other site 320388008964 putative PBP binding loops; other site 320388008965 ABC-ATPase subunit interface; other site 320388008966 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 320388008967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388008968 Walker A/P-loop; other site 320388008969 ATP binding site [chemical binding]; other site 320388008970 Q-loop/lid; other site 320388008971 ABC transporter signature motif; other site 320388008972 Walker B; other site 320388008973 D-loop; other site 320388008974 H-loop/switch region; other site 320388008975 TOBE domain; Region: TOBE_2; pfam08402 320388008976 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 320388008977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320388008978 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 320388008979 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320388008980 Predicted Fe-S protein [General function prediction only]; Region: COG3313 320388008981 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320388008982 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 320388008983 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320388008984 FMN binding site [chemical binding]; other site 320388008985 substrate binding site [chemical binding]; other site 320388008986 putative catalytic residue [active] 320388008987 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 320388008988 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388008989 NAD binding site [chemical binding]; other site 320388008990 catalytic residues [active] 320388008991 Burkholderia Lethal Factor 1; Region: BPSL1549; cd12812 320388008992 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 320388008993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388008994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388008995 ABC transporter; Region: ABC_tran_2; pfam12848 320388008996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388008997 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 320388008998 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 320388008999 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 320388009000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388009001 Walker A/P-loop; other site 320388009002 ATP binding site [chemical binding]; other site 320388009003 Q-loop/lid; other site 320388009004 ABC transporter signature motif; other site 320388009005 Walker B; other site 320388009006 D-loop; other site 320388009007 H-loop/switch region; other site 320388009008 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 320388009009 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 320388009010 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 320388009011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388009012 motif II; other site 320388009013 cystathionine beta-lyase; Provisional; Region: PRK07050 320388009014 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388009015 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388009016 catalytic residue [active] 320388009017 beta-ketothiolase; Provisional; Region: PRK09051 320388009018 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388009019 dimer interface [polypeptide binding]; other site 320388009020 active site 320388009021 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388009022 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320388009023 substrate binding site [chemical binding]; other site 320388009024 ATP binding site [chemical binding]; other site 320388009025 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 320388009026 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 320388009027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388009028 FeS/SAM binding site; other site 320388009029 TRAM domain; Region: TRAM; cl01282 320388009030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 320388009031 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 320388009032 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 320388009033 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 320388009034 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320388009035 NAD(P) binding site [chemical binding]; other site 320388009036 homotetramer interface [polypeptide binding]; other site 320388009037 homodimer interface [polypeptide binding]; other site 320388009038 active site 320388009039 putative acyltransferase; Provisional; Region: PRK05790 320388009040 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388009041 dimer interface [polypeptide binding]; other site 320388009042 active site 320388009043 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 320388009044 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 320388009045 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 320388009046 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 320388009047 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 320388009048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388009049 RNA binding surface [nucleotide binding]; other site 320388009050 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320388009051 active site 320388009052 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 320388009053 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 320388009054 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 320388009055 DEAD_2; Region: DEAD_2; pfam06733 320388009056 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 320388009057 Protein of unknown function (DUF465); Region: DUF465; pfam04325 320388009058 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 320388009059 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 320388009060 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 320388009061 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 320388009062 RNA binding site [nucleotide binding]; other site 320388009063 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 320388009064 potassium uptake protein; Region: kup; TIGR00794 320388009065 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 320388009066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388009067 active site 320388009068 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 320388009069 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 320388009070 GDP-binding site [chemical binding]; other site 320388009071 ACT binding site; other site 320388009072 IMP binding site; other site 320388009073 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 320388009074 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 320388009075 dimer interface [polypeptide binding]; other site 320388009076 motif 1; other site 320388009077 active site 320388009078 motif 2; other site 320388009079 motif 3; other site 320388009080 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 320388009081 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 320388009082 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 320388009083 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 320388009084 HflK protein; Region: hflK; TIGR01933 320388009085 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 320388009086 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 320388009087 HflX GTPase family; Region: HflX; cd01878 320388009088 G1 box; other site 320388009089 GTP/Mg2+ binding site [chemical binding]; other site 320388009090 Switch I region; other site 320388009091 G2 box; other site 320388009092 G3 box; other site 320388009093 Switch II region; other site 320388009094 G4 box; other site 320388009095 G5 box; other site 320388009096 bacterial Hfq-like; Region: Hfq; cd01716 320388009097 hexamer interface [polypeptide binding]; other site 320388009098 Sm1 motif; other site 320388009099 RNA binding site [nucleotide binding]; other site 320388009100 Sm2 motif; other site 320388009101 GTP-binding protein Der; Reviewed; Region: PRK00093 320388009102 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 320388009103 G1 box; other site 320388009104 GTP/Mg2+ binding site [chemical binding]; other site 320388009105 Switch I region; other site 320388009106 G2 box; other site 320388009107 Switch II region; other site 320388009108 G3 box; other site 320388009109 G4 box; other site 320388009110 G5 box; other site 320388009111 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 320388009112 G1 box; other site 320388009113 GTP/Mg2+ binding site [chemical binding]; other site 320388009114 Switch I region; other site 320388009115 G2 box; other site 320388009116 G3 box; other site 320388009117 Switch II region; other site 320388009118 G4 box; other site 320388009119 G5 box; other site 320388009120 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 320388009121 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 320388009122 Trp docking motif [polypeptide binding]; other site 320388009123 active site 320388009124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 320388009125 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 320388009126 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 320388009127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 320388009128 dimer interface [polypeptide binding]; other site 320388009129 motif 1; other site 320388009130 active site 320388009131 motif 2; other site 320388009132 motif 3; other site 320388009133 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 320388009134 anticodon binding site; other site 320388009135 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320388009136 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 320388009137 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320388009138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388009139 non-specific DNA binding site [nucleotide binding]; other site 320388009140 salt bridge; other site 320388009141 sequence-specific DNA binding site [nucleotide binding]; other site 320388009142 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 320388009143 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 320388009144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388009145 FeS/SAM binding site; other site 320388009146 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 320388009147 active site 320388009148 multimer interface [polypeptide binding]; other site 320388009149 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 320388009150 YccA-like proteins; Region: YccA_like; cd10433 320388009151 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 320388009152 TRAM domain; Region: TRAM; cl01282 320388009153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388009154 S-adenosylmethionine binding site [chemical binding]; other site 320388009155 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 320388009156 putative catalytic site [active] 320388009157 putative metal binding site [ion binding]; other site 320388009158 putative phosphate binding site [ion binding]; other site 320388009159 putative catalytic site [active] 320388009160 putative phosphate binding site [ion binding]; other site 320388009161 putative metal binding site [ion binding]; other site 320388009162 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 320388009163 active site 320388009164 catalytic site [active] 320388009165 substrate binding site [chemical binding]; other site 320388009166 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 320388009167 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 320388009168 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320388009169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388009170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388009171 DNA binding residues [nucleotide binding] 320388009172 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320388009173 Peptidase family M23; Region: Peptidase_M23; pfam01551 320388009174 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 320388009175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388009176 S-adenosylmethionine binding site [chemical binding]; other site 320388009177 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 320388009178 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388009179 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388009180 recombination protein RecR; Reviewed; Region: recR; PRK00076 320388009181 RecR protein; Region: RecR; pfam02132 320388009182 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 320388009183 putative active site [active] 320388009184 putative metal-binding site [ion binding]; other site 320388009185 tetramer interface [polypeptide binding]; other site 320388009186 hypothetical protein; Validated; Region: PRK00153 320388009187 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 320388009188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388009189 Walker A motif; other site 320388009190 ATP binding site [chemical binding]; other site 320388009191 Walker B motif; other site 320388009192 arginine finger; other site 320388009193 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 320388009194 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320388009195 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388009196 catalytic residues [active] 320388009197 transcription termination factor Rho; Provisional; Region: rho; PRK09376 320388009198 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 320388009199 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 320388009200 RNA binding site [nucleotide binding]; other site 320388009201 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 320388009202 multimer interface [polypeptide binding]; other site 320388009203 Walker A motif; other site 320388009204 ATP binding site [chemical binding]; other site 320388009205 Walker B motif; other site 320388009206 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 320388009207 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320388009208 DNA binding residues [nucleotide binding] 320388009209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388009210 putative substrate translocation pore; other site 320388009211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388009212 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 320388009213 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 320388009214 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320388009215 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 320388009216 putative efflux protein, MATE family; Region: matE; TIGR00797 320388009217 cation binding site [ion binding]; other site 320388009218 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 320388009219 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 320388009220 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 320388009221 DNA binding residues [nucleotide binding] 320388009222 putative dimer interface [polypeptide binding]; other site 320388009223 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 320388009224 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 320388009225 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 320388009226 Clp amino terminal domain; Region: Clp_N; pfam02861 320388009227 Clp amino terminal domain; Region: Clp_N; pfam02861 320388009228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388009229 Walker A motif; other site 320388009230 ATP binding site [chemical binding]; other site 320388009231 Walker B motif; other site 320388009232 arginine finger; other site 320388009233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388009234 Walker A motif; other site 320388009235 ATP binding site [chemical binding]; other site 320388009236 Walker B motif; other site 320388009237 arginine finger; other site 320388009238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320388009239 Transcriptional regulator; Region: Rrf2; cl17282 320388009240 Rrf2 family protein; Region: rrf2_super; TIGR00738 320388009241 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 320388009242 apolar tunnel; other site 320388009243 heme binding site [chemical binding]; other site 320388009244 dimerization interface [polypeptide binding]; other site 320388009245 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 320388009246 MoaE homodimer interface [polypeptide binding]; other site 320388009247 MoaD interaction [polypeptide binding]; other site 320388009248 active site residues [active] 320388009249 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 320388009250 MoaE interaction surface [polypeptide binding]; other site 320388009251 MoeB interaction surface [polypeptide binding]; other site 320388009252 thiocarboxylated glycine; other site 320388009253 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 320388009254 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 320388009255 dimer interface [polypeptide binding]; other site 320388009256 putative functional site; other site 320388009257 putative MPT binding site; other site 320388009258 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 320388009259 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 320388009260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009261 catalytic residue [active] 320388009262 homoserine dehydrogenase; Provisional; Region: PRK06349 320388009263 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 320388009264 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 320388009265 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 320388009266 aminotransferase AlaT; Validated; Region: PRK09265 320388009267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388009268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009269 homodimer interface [polypeptide binding]; other site 320388009270 catalytic residue [active] 320388009271 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 320388009272 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320388009273 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 320388009274 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 320388009275 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 320388009276 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320388009277 inhibitor-cofactor binding pocket; inhibition site 320388009278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009279 catalytic residue [active] 320388009280 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 320388009281 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 320388009282 Ligand binding site; other site 320388009283 Putative Catalytic site; other site 320388009284 DXD motif; other site 320388009285 putative formyltransferase; Provisional; Region: PRK06988 320388009286 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 320388009287 active site 320388009288 substrate binding site [chemical binding]; other site 320388009289 cosubstrate binding site; other site 320388009290 catalytic site [active] 320388009291 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 320388009292 active site 320388009293 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 320388009294 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 320388009295 NAD binding site [chemical binding]; other site 320388009296 substrate binding site [chemical binding]; other site 320388009297 active site 320388009298 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 320388009299 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 320388009300 putative active site [active] 320388009301 putative catalytic site [active] 320388009302 putative Zn binding site [ion binding]; other site 320388009303 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 320388009304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388009305 catalytic triad [active] 320388009306 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 320388009307 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 320388009308 putative active site [active] 320388009309 PhoH-like protein; Region: PhoH; pfam02562 320388009310 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 320388009311 NlpC/P60 family; Region: NLPC_P60; pfam00877 320388009312 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 320388009313 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 320388009314 replicative DNA helicase; Provisional; Region: PRK07004 320388009315 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 320388009316 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 320388009317 Walker A motif; other site 320388009318 ATP binding site [chemical binding]; other site 320388009319 Walker B motif; other site 320388009320 DNA binding loops [nucleotide binding] 320388009321 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 320388009322 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 320388009323 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 320388009324 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 320388009325 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 320388009326 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 320388009327 Putative zinc-finger; Region: zf-HC2; pfam13490 320388009328 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 320388009329 RNA polymerase sigma factor; Provisional; Region: PRK12533 320388009330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388009331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388009332 DNA binding residues [nucleotide binding] 320388009333 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320388009334 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388009335 active site 320388009336 metal binding site [ion binding]; metal-binding site 320388009337 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320388009338 HTH-like domain; Region: HTH_21; pfam13276 320388009339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388009340 Integrase core domain; Region: rve; pfam00665 320388009341 Integrase core domain; Region: rve_3; pfam13683 320388009342 Transposase; Region: HTH_Tnp_1; pfam01527 320388009343 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 320388009344 active site 320388009345 homodimer interface [polypeptide binding]; other site 320388009346 homotetramer interface [polypeptide binding]; other site 320388009347 psiF repeat; Region: PsiF_repeat; pfam07769 320388009348 psiF repeat; Region: PsiF_repeat; pfam07769 320388009349 Domain of unknown function DUF221; Region: DUF221; pfam02714 320388009350 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 320388009351 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320388009352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388009353 putative ADP-binding pocket [chemical binding]; other site 320388009354 Predicted ATPase [General function prediction only]; Region: COG4637 320388009355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388009356 Walker A/P-loop; other site 320388009357 ATP binding site [chemical binding]; other site 320388009358 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 320388009359 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320388009360 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320388009361 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320388009362 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320388009363 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 320388009364 active site 320388009365 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 320388009366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388009367 Coenzyme A binding pocket [chemical binding]; other site 320388009368 DNA polymerase III subunit delta'; Validated; Region: PRK06964 320388009369 DNA polymerase III subunit delta'; Validated; Region: PRK08485 320388009370 thymidylate kinase; Validated; Region: tmk; PRK00698 320388009371 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 320388009372 TMP-binding site; other site 320388009373 ATP-binding site [chemical binding]; other site 320388009374 YceG-like family; Region: YceG; pfam02618 320388009375 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 320388009376 dimerization interface [polypeptide binding]; other site 320388009377 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 320388009378 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 320388009379 NRDE protein; Region: NRDE; cl01315 320388009380 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 320388009381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388009382 Coenzyme A binding pocket [chemical binding]; other site 320388009383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 320388009384 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320388009385 substrate binding pocket [chemical binding]; other site 320388009386 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320388009387 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320388009388 NAD(P) binding site [chemical binding]; other site 320388009389 substrate binding site [chemical binding]; other site 320388009390 dimer interface [polypeptide binding]; other site 320388009391 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320388009392 CoenzymeA binding site [chemical binding]; other site 320388009393 subunit interaction site [polypeptide binding]; other site 320388009394 PHB binding site; other site 320388009395 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 320388009396 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 320388009397 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388009398 dimer interface [polypeptide binding]; other site 320388009399 active site 320388009400 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 320388009401 catalytic triad [active] 320388009402 metal binding site [ion binding]; metal-binding site 320388009403 conserved cis-peptide bond; other site 320388009404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388009405 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320388009406 substrate binding site [chemical binding]; other site 320388009407 oxyanion hole (OAH) forming residues; other site 320388009408 trimer interface [polypeptide binding]; other site 320388009409 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388009410 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388009411 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388009412 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 320388009413 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 320388009414 dimer interface [polypeptide binding]; other site 320388009415 acyl-activating enzyme (AAE) consensus motif; other site 320388009416 putative active site [active] 320388009417 AMP binding site [chemical binding]; other site 320388009418 putative CoA binding site [chemical binding]; other site 320388009419 Uncharacterized conserved protein [Function unknown]; Region: COG0397 320388009420 hypothetical protein; Validated; Region: PRK00029 320388009421 SelR domain; Region: SelR; pfam01641 320388009422 methionine sulfoxide reductase B; Provisional; Region: PRK00222 320388009423 intracellular septation protein A; Reviewed; Region: PRK00259 320388009424 BolA-like protein; Region: BolA; pfam01722 320388009425 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 320388009426 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320388009427 Predicted acetyltransferase [General function prediction only]; Region: COG3153 320388009428 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 320388009429 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 320388009430 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 320388009431 dimerization interface [polypeptide binding]; other site 320388009432 ATP binding site [chemical binding]; other site 320388009433 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 320388009434 dimerization interface [polypeptide binding]; other site 320388009435 ATP binding site [chemical binding]; other site 320388009436 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 320388009437 putative active site [active] 320388009438 catalytic triad [active] 320388009439 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320388009440 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 320388009441 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 320388009442 putative substrate binding site [chemical binding]; other site 320388009443 putative ATP binding site [chemical binding]; other site 320388009444 similar to hypothetical protein 320388009445 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 320388009446 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 320388009447 active site 320388009448 dimer interface [polypeptide binding]; other site 320388009449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 320388009450 dimer interface [polypeptide binding]; other site 320388009451 active site 320388009452 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 320388009453 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320388009454 Walker A/P-loop; other site 320388009455 ATP binding site [chemical binding]; other site 320388009456 Q-loop/lid; other site 320388009457 ABC transporter signature motif; other site 320388009458 Walker B; other site 320388009459 D-loop; other site 320388009460 H-loop/switch region; other site 320388009461 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 320388009462 active site 320388009463 catalytic triad [active] 320388009464 oxyanion hole [active] 320388009465 switch loop; other site 320388009466 SurA N-terminal domain; Region: SurA_N_3; cl07813 320388009467 periplasmic folding chaperone; Provisional; Region: PRK10788 320388009468 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320388009469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 320388009470 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 320388009471 30S subunit binding site; other site 320388009472 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 320388009473 Found in ATP-dependent protease La (LON); Region: LON; smart00464 320388009474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388009475 Walker A motif; other site 320388009476 ATP binding site [chemical binding]; other site 320388009477 Walker B motif; other site 320388009478 arginine finger; other site 320388009479 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 320388009480 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 320388009481 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 320388009482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388009483 Walker A motif; other site 320388009484 ATP binding site [chemical binding]; other site 320388009485 Walker B motif; other site 320388009486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320388009487 Clp protease; Region: CLP_protease; pfam00574 320388009488 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 320388009489 oligomer interface [polypeptide binding]; other site 320388009490 active site residues [active] 320388009491 trigger factor; Provisional; Region: tig; PRK01490 320388009492 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320388009493 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 320388009494 Glycerate kinase family; Region: Gly_kinase; cl00841 320388009495 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320388009496 MarR family; Region: MarR_2; pfam12802 320388009497 MarR family; Region: MarR_2; cl17246 320388009498 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 320388009499 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320388009500 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320388009501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388009502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388009503 dimerization interface [polypeptide binding]; other site 320388009504 DNA binding residues [nucleotide binding] 320388009505 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388009506 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388009507 trimer interface [polypeptide binding]; other site 320388009508 eyelet of channel; other site 320388009509 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 320388009510 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320388009511 active site 320388009512 Zn binding site [ion binding]; other site 320388009513 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 320388009514 PLD-like domain; Region: PLDc_2; pfam13091 320388009515 putative active site [active] 320388009516 catalytic site [active] 320388009517 HTH-like domain; Region: HTH_21; pfam13276 320388009518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388009519 Integrase core domain; Region: rve; pfam00665 320388009520 Integrase core domain; Region: rve_3; pfam13683 320388009521 Transposase; Region: HTH_Tnp_1; pfam01527 320388009522 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320388009523 active site lid residues [active] 320388009524 substrate binding pocket [chemical binding]; other site 320388009525 catalytic residues [active] 320388009526 substrate-Mg2+ binding site; other site 320388009527 aspartate-rich region 1; other site 320388009528 aspartate-rich region 2; other site 320388009529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 320388009530 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 320388009531 osmolarity response regulator; Provisional; Region: ompR; PRK09468 320388009532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388009533 active site 320388009534 phosphorylation site [posttranslational modification] 320388009535 intermolecular recognition site; other site 320388009536 dimerization interface [polypeptide binding]; other site 320388009537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388009538 DNA binding site [nucleotide binding] 320388009539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388009540 HAMP domain; Region: HAMP; pfam00672 320388009541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388009542 dimer interface [polypeptide binding]; other site 320388009543 phosphorylation site [posttranslational modification] 320388009544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388009545 ATP binding site [chemical binding]; other site 320388009546 Mg2+ binding site [ion binding]; other site 320388009547 G-X-G motif; other site 320388009548 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320388009549 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 320388009550 dimer interface [polypeptide binding]; other site 320388009551 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320388009552 catalytic triad [active] 320388009553 peroxidatic and resolving cysteines [active] 320388009554 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 320388009555 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 320388009556 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 320388009557 homotrimer interaction site [polypeptide binding]; other site 320388009558 zinc binding site [ion binding]; other site 320388009559 CDP-binding sites; other site 320388009560 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 320388009561 substrate binding site; other site 320388009562 dimer interface; other site 320388009563 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 320388009564 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 320388009565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388009566 ATP binding site [chemical binding]; other site 320388009567 putative Mg++ binding site [ion binding]; other site 320388009568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388009569 nucleotide binding region [chemical binding]; other site 320388009570 ATP-binding site [chemical binding]; other site 320388009571 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 320388009572 acetylornithine deacetylase; Provisional; Region: PRK07522 320388009573 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 320388009574 metal binding site [ion binding]; metal-binding site 320388009575 putative dimer interface [polypeptide binding]; other site 320388009576 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320388009577 tetramer interface [polypeptide binding]; other site 320388009578 hypothetical protein; Provisional; Region: PRK06815 320388009579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009580 catalytic residue [active] 320388009581 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 320388009582 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 320388009583 Transglycosylase; Region: Transgly; pfam00912 320388009584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320388009585 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 320388009586 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320388009587 Tetratricopeptide repeat; Region: TPR_16; pfam13432 320388009588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388009589 TPR motif; other site 320388009590 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 320388009591 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 320388009592 Transposase domain (DUF772); Region: DUF772; pfam05598 320388009593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388009594 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388009595 ureidoglycolate hydrolase; Provisional; Region: PRK03606 320388009596 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 320388009597 allantoicase; Provisional; Region: PRK13257 320388009598 Allantoicase repeat; Region: Allantoicase; pfam03561 320388009599 Allantoicase repeat; Region: Allantoicase; pfam03561 320388009600 OHCU decarboxylase; Region: UHCUDC; TIGR03164 320388009601 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 320388009602 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 320388009603 active site 320388009604 catalytic site [active] 320388009605 tetramer interface [polypeptide binding]; other site 320388009606 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 320388009607 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 320388009608 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 320388009609 Na binding site [ion binding]; other site 320388009610 putative substrate binding site [chemical binding]; other site 320388009611 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320388009612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388009613 DNA-binding site [nucleotide binding]; DNA binding site 320388009614 FCD domain; Region: FCD; pfam07729 320388009615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388009616 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388009617 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 320388009618 dimer interface [polypeptide binding]; other site 320388009619 catalytic triad [active] 320388009620 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 320388009621 nucleoside/Zn binding site; other site 320388009622 dimer interface [polypeptide binding]; other site 320388009623 catalytic motif [active] 320388009624 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 320388009625 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 320388009626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388009627 GMP synthase; Reviewed; Region: guaA; PRK00074 320388009628 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 320388009629 AMP/PPi binding site [chemical binding]; other site 320388009630 candidate oxyanion hole; other site 320388009631 catalytic triad [active] 320388009632 potential glutamine specificity residues [chemical binding]; other site 320388009633 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 320388009634 ATP Binding subdomain [chemical binding]; other site 320388009635 Ligand Binding sites [chemical binding]; other site 320388009636 Dimerization subdomain; other site 320388009637 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 320388009638 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320388009639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 320388009640 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 320388009641 active site 320388009642 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 320388009643 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 320388009644 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388009645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 320388009646 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 320388009647 putative coenzyme Q binding site [chemical binding]; other site 320388009648 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 320388009649 SmpB-tmRNA interface; other site 320388009650 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 320388009651 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 320388009652 phosphoenolpyruvate synthase; Validated; Region: PRK06464 320388009653 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 320388009654 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320388009655 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320388009656 Phytochelatin synthase; Region: Phytochelatin; pfam05023 320388009657 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320388009658 peptidase domain interface [polypeptide binding]; other site 320388009659 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320388009660 active site 320388009661 catalytic triad [active] 320388009662 calcium binding site [ion binding]; other site 320388009663 PEP synthetase regulatory protein; Provisional; Region: PRK05339 320388009664 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 320388009665 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 320388009666 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 320388009667 RNA/DNA hybrid binding site [nucleotide binding]; other site 320388009668 active site 320388009669 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 320388009670 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 320388009671 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 320388009672 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 320388009673 active site 320388009674 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 320388009675 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 320388009676 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 320388009677 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 320388009678 trimer interface [polypeptide binding]; other site 320388009679 active site 320388009680 UDP-GlcNAc binding site [chemical binding]; other site 320388009681 lipid binding site [chemical binding]; lipid-binding site 320388009682 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 320388009683 periplasmic chaperone; Provisional; Region: PRK10780 320388009684 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 320388009685 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320388009686 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320388009687 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320388009688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320388009689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320388009690 Surface antigen; Region: Bac_surface_Ag; pfam01103 320388009691 zinc metallopeptidase RseP; Provisional; Region: PRK10779 320388009692 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 320388009693 active site 320388009694 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 320388009695 protein binding site [polypeptide binding]; other site 320388009696 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 320388009697 putative substrate binding region [chemical binding]; other site 320388009698 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 320388009699 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 320388009700 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 320388009701 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 320388009702 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 320388009703 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 320388009704 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 320388009705 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 320388009706 catalytic residue [active] 320388009707 putative FPP diphosphate binding site; other site 320388009708 putative FPP binding hydrophobic cleft; other site 320388009709 dimer interface [polypeptide binding]; other site 320388009710 putative IPP diphosphate binding site; other site 320388009711 ribosome recycling factor; Reviewed; Region: frr; PRK00083 320388009712 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 320388009713 hinge region; other site 320388009714 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 320388009715 putative nucleotide binding site [chemical binding]; other site 320388009716 uridine monophosphate binding site [chemical binding]; other site 320388009717 homohexameric interface [polypeptide binding]; other site 320388009718 elongation factor Ts; Provisional; Region: tsf; PRK09377 320388009719 UBA/TS-N domain; Region: UBA; pfam00627 320388009720 Elongation factor TS; Region: EF_TS; pfam00889 320388009721 Elongation factor TS; Region: EF_TS; pfam00889 320388009722 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 320388009723 rRNA interaction site [nucleotide binding]; other site 320388009724 S8 interaction site; other site 320388009725 putative laminin-1 binding site; other site 320388009726 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 320388009727 active site 320388009728 PII uridylyl-transferase; Provisional; Region: PRK03059 320388009729 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320388009730 metal binding triad; other site 320388009731 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320388009732 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320388009733 Zn2+ binding site [ion binding]; other site 320388009734 Mg2+ binding site [ion binding]; other site 320388009735 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 320388009736 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 320388009737 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320388009738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388009739 RNA binding surface [nucleotide binding]; other site 320388009740 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 320388009741 active site 320388009742 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320388009743 active site 320388009744 catalytic residues [active] 320388009745 metal binding site [ion binding]; metal-binding site 320388009746 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 320388009747 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 320388009748 nucleotide binding pocket [chemical binding]; other site 320388009749 K-X-D-G motif; other site 320388009750 catalytic site [active] 320388009751 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 320388009752 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 320388009753 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 320388009754 Dimer interface [polypeptide binding]; other site 320388009755 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 320388009756 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 320388009757 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 320388009758 Walker A/P-loop; other site 320388009759 ATP binding site [chemical binding]; other site 320388009760 Q-loop/lid; other site 320388009761 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 320388009762 Q-loop/lid; other site 320388009763 ABC transporter signature motif; other site 320388009764 Walker B; other site 320388009765 D-loop; other site 320388009766 H-loop/switch region; other site 320388009767 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320388009768 EamA-like transporter family; Region: EamA; pfam00892 320388009769 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 320388009770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388009771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009772 homodimer interface [polypeptide binding]; other site 320388009773 catalytic residue [active] 320388009774 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 320388009775 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 320388009776 trimer interface [polypeptide binding]; other site 320388009777 active site 320388009778 substrate binding site [chemical binding]; other site 320388009779 CoA binding site [chemical binding]; other site 320388009780 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 320388009781 ArsC family; Region: ArsC; pfam03960 320388009782 putative catalytic residues [active] 320388009783 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 320388009784 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 320388009785 metal binding site [ion binding]; metal-binding site 320388009786 dimer interface [polypeptide binding]; other site 320388009787 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 320388009788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388009789 S-adenosylmethionine binding site [chemical binding]; other site 320388009790 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 320388009791 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 320388009792 putative active site [active] 320388009793 catalytic site [active] 320388009794 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 320388009795 putative active site [active] 320388009796 catalytic site [active] 320388009797 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 320388009798 catalytic residues [active] 320388009799 dimer interface [polypeptide binding]; other site 320388009800 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 320388009801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388009802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388009803 ABC transporter; Region: ABC_tran_2; pfam12848 320388009804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388009805 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 320388009806 DNA repair protein RadA; Provisional; Region: PRK11823 320388009807 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 320388009808 Walker A motif/ATP binding site; other site 320388009809 ATP binding site [chemical binding]; other site 320388009810 Walker B motif; other site 320388009811 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320388009812 alanine racemase; Reviewed; Region: dadX; PRK03646 320388009813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 320388009814 active site 320388009815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388009816 substrate binding site [chemical binding]; other site 320388009817 catalytic residues [active] 320388009818 dimer interface [polypeptide binding]; other site 320388009819 lysophospholipid transporter LplT; Provisional; Region: PRK11195 320388009820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388009821 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320388009822 dimer interface [polypeptide binding]; other site 320388009823 substrate binding site [chemical binding]; other site 320388009824 ATP binding site [chemical binding]; other site 320388009825 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 320388009826 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 320388009827 Fe-S cluster binding site [ion binding]; other site 320388009828 active site 320388009829 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 320388009830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388009831 Coenzyme A binding pocket [chemical binding]; other site 320388009832 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320388009833 Glycoprotease family; Region: Peptidase_M22; pfam00814 320388009834 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 320388009835 acyl-CoA binding pocket [chemical binding]; other site 320388009836 CoA binding site [chemical binding]; other site 320388009837 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320388009838 DEAD-like helicases superfamily; Region: DEXDc; smart00487 320388009839 ATP binding site [chemical binding]; other site 320388009840 Mg++ binding site [ion binding]; other site 320388009841 motif III; other site 320388009842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388009843 nucleotide binding region [chemical binding]; other site 320388009844 ATP-binding site [chemical binding]; other site 320388009845 Transposase domain (DUF772); Region: DUF772; pfam05598 320388009846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388009847 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388009848 isocitrate lyase; Provisional; Region: PRK15063 320388009849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320388009850 tetramer interface [polypeptide binding]; other site 320388009851 active site 320388009852 Mg2+/Mn2+ binding site [ion binding]; other site 320388009853 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320388009854 Ligand Binding Site [chemical binding]; other site 320388009855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388009856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388009857 putative effector binding pocket; other site 320388009858 dimerization interface [polypeptide binding]; other site 320388009859 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 320388009860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388009861 motif II; other site 320388009862 malate synthase A; Region: malate_syn_A; TIGR01344 320388009863 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 320388009864 active site 320388009865 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 320388009866 putative active site pocket [active] 320388009867 dimerization interface [polypeptide binding]; other site 320388009868 putative catalytic residue [active] 320388009869 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 320388009870 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320388009871 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320388009872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388009873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388009874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388009875 Coenzyme A binding pocket [chemical binding]; other site 320388009876 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 320388009877 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320388009878 active site 320388009879 HIGH motif; other site 320388009880 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320388009881 active site 320388009882 KMSKS motif; other site 320388009883 hypothetical protein; Provisional; Region: PRK10279 320388009884 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 320388009885 nucleophile elbow; other site 320388009886 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 320388009887 NlpC/P60 family; Region: NLPC_P60; pfam00877 320388009888 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 320388009889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388009890 Walker A/P-loop; other site 320388009891 ATP binding site [chemical binding]; other site 320388009892 Q-loop/lid; other site 320388009893 ABC transporter signature motif; other site 320388009894 Walker B; other site 320388009895 D-loop; other site 320388009896 H-loop/switch region; other site 320388009897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388009898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388009899 Walker A/P-loop; other site 320388009900 ATP binding site [chemical binding]; other site 320388009901 Q-loop/lid; other site 320388009902 ABC transporter signature motif; other site 320388009903 Walker B; other site 320388009904 D-loop; other site 320388009905 H-loop/switch region; other site 320388009906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388009907 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 320388009908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388009909 dimer interface [polypeptide binding]; other site 320388009910 conserved gate region; other site 320388009911 putative PBP binding loops; other site 320388009912 ABC-ATPase subunit interface; other site 320388009913 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 320388009914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388009915 dimer interface [polypeptide binding]; other site 320388009916 conserved gate region; other site 320388009917 putative PBP binding loops; other site 320388009918 ABC-ATPase subunit interface; other site 320388009919 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 320388009920 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 320388009921 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 320388009922 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 320388009923 NAD binding site [chemical binding]; other site 320388009924 homotetramer interface [polypeptide binding]; other site 320388009925 homodimer interface [polypeptide binding]; other site 320388009926 substrate binding site [chemical binding]; other site 320388009927 active site 320388009928 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320388009929 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 320388009930 putative [Fe4-S4] binding site [ion binding]; other site 320388009931 putative molybdopterin cofactor binding site [chemical binding]; other site 320388009932 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388009933 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 320388009934 putative molybdopterin cofactor binding site; other site 320388009935 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320388009936 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 320388009937 FAD binding pocket [chemical binding]; other site 320388009938 FAD binding motif [chemical binding]; other site 320388009939 phosphate binding motif [ion binding]; other site 320388009940 beta-alpha-beta structure motif; other site 320388009941 NAD binding pocket [chemical binding]; other site 320388009942 Ferredoxin [Energy production and conversion]; Region: COG1146 320388009943 4Fe-4S binding domain; Region: Fer4; cl02805 320388009944 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 320388009945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388009946 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 320388009947 active site 320388009948 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 320388009949 argininosuccinate lyase; Provisional; Region: PRK02186 320388009950 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320388009951 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320388009952 active sites [active] 320388009953 tetramer interface [polypeptide binding]; other site 320388009954 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320388009955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388009956 catalytic residue [active] 320388009957 dimer interface [polypeptide binding]; other site 320388009958 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 320388009959 G1 box; other site 320388009960 GTP/Mg2+ binding site [chemical binding]; other site 320388009961 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 320388009962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 320388009963 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 320388009964 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320388009965 Active Sites [active] 320388009966 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320388009967 active site 320388009968 phosphoserine aminotransferase; Provisional; Region: PRK12462 320388009969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388009970 catalytic residue [active] 320388009971 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320388009972 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 320388009973 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320388009974 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 320388009975 PYR/PP interface [polypeptide binding]; other site 320388009976 dimer interface [polypeptide binding]; other site 320388009977 TPP binding site [chemical binding]; other site 320388009978 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 320388009979 TPP-binding site [chemical binding]; other site 320388009980 dimer interface [polypeptide binding]; other site 320388009981 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 320388009982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388009983 S-adenosylmethionine binding site [chemical binding]; other site 320388009984 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320388009985 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320388009986 active site 320388009987 iron coordination sites [ion binding]; other site 320388009988 substrate binding pocket [chemical binding]; other site 320388009989 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 320388009990 Condensation domain; Region: Condensation; pfam00668 320388009991 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 320388009992 Condensation domain; Region: Condensation; pfam00668 320388009993 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388009994 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320388009995 acyl-activating enzyme (AAE) consensus motif; other site 320388009996 AMP binding site [chemical binding]; other site 320388009997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388009998 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320388009999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 320388010000 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 320388010001 Condensation domain; Region: Condensation; pfam00668 320388010002 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320388010003 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320388010004 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388010005 acyl-activating enzyme (AAE) consensus motif; other site 320388010006 AMP binding site [chemical binding]; other site 320388010007 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388010008 Transmembrane secretion effector; Region: MFS_3; pfam05977 320388010009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388010010 putative substrate translocation pore; other site 320388010011 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320388010012 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320388010013 acyl-activating enzyme (AAE) consensus motif; other site 320388010014 AMP binding site [chemical binding]; other site 320388010015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320388010016 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320388010017 ligand-binding site [chemical binding]; other site 320388010018 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320388010019 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320388010020 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388010021 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 320388010022 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 320388010023 active site 320388010024 catalytic triad [active] 320388010025 oxyanion hole [active] 320388010026 Autotransporter beta-domain; Region: Autotransporter; smart00869 320388010027 aspartate kinase; Reviewed; Region: PRK06635 320388010028 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 320388010029 putative nucleotide binding site [chemical binding]; other site 320388010030 putative catalytic residues [active] 320388010031 putative Mg ion binding site [ion binding]; other site 320388010032 putative aspartate binding site [chemical binding]; other site 320388010033 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 320388010034 putative allosteric regulatory site; other site 320388010035 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 320388010036 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 320388010037 Ligand Binding Site [chemical binding]; other site 320388010038 TilS substrate binding domain; Region: TilS; pfam09179 320388010039 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 320388010040 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 320388010041 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 320388010042 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320388010043 endonuclease III; Region: ENDO3c; smart00478 320388010044 minor groove reading motif; other site 320388010045 helix-hairpin-helix signature motif; other site 320388010046 substrate binding pocket [chemical binding]; other site 320388010047 active site 320388010048 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 320388010049 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320388010050 active site 320388010051 HIGH motif; other site 320388010052 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320388010053 KMSKS motif; other site 320388010054 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 320388010055 tRNA binding surface [nucleotide binding]; other site 320388010056 anticodon binding site; other site 320388010057 TPR repeat; Region: TPR_11; pfam13414 320388010058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388010059 binding surface 320388010060 TPR motif; other site 320388010061 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 320388010062 substrate binding site [chemical binding]; other site 320388010063 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 320388010064 substrate binding site [chemical binding]; other site 320388010065 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320388010066 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 320388010067 putative active site [active] 320388010068 putative metal binding site [ion binding]; other site 320388010069 serine O-acetyltransferase; Region: cysE; TIGR01172 320388010070 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320388010071 trimer interface [polypeptide binding]; other site 320388010072 active site 320388010073 substrate binding site [chemical binding]; other site 320388010074 CoA binding site [chemical binding]; other site 320388010075 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 320388010076 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 320388010077 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 320388010078 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 320388010079 active site 320388010080 dimerization interface [polypeptide binding]; other site 320388010081 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 320388010082 MutS domain I; Region: MutS_I; pfam01624 320388010083 MutS domain II; Region: MutS_II; pfam05188 320388010084 MutS domain III; Region: MutS_III; pfam05192 320388010085 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 320388010086 Walker A/P-loop; other site 320388010087 ATP binding site [chemical binding]; other site 320388010088 Q-loop/lid; other site 320388010089 ABC transporter signature motif; other site 320388010090 Walker B; other site 320388010091 D-loop; other site 320388010092 H-loop/switch region; other site 320388010093 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 320388010094 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 320388010095 Uncharacterized conserved protein [Function unknown]; Region: COG2850 320388010096 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 320388010097 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 320388010098 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 320388010099 dihydrodipicolinate synthase; Region: dapA; TIGR00674 320388010100 dimer interface [polypeptide binding]; other site 320388010101 active site 320388010102 catalytic residue [active] 320388010103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388010104 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 320388010105 active site 320388010106 HIGH motif; other site 320388010107 dimer interface [polypeptide binding]; other site 320388010108 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388010109 active site 320388010110 KMSKS motif; other site 320388010111 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 320388010112 Peptidase family M50; Region: Peptidase_M50; pfam02163 320388010113 active site 320388010114 putative substrate binding region [chemical binding]; other site 320388010115 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 320388010116 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 320388010117 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 320388010118 active site 320388010119 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 320388010120 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388010121 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320388010122 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 320388010123 catalytic site [active] 320388010124 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320388010125 dinuclear metal binding motif [ion binding]; other site 320388010126 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 320388010127 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 320388010128 trimer interface [polypeptide binding]; other site 320388010129 putative metal binding site [ion binding]; other site 320388010130 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 320388010131 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 320388010132 dimerization interface [polypeptide binding]; other site 320388010133 domain crossover interface; other site 320388010134 redox-dependent activation switch; other site 320388010135 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 320388010136 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 320388010137 enolase; Provisional; Region: eno; PRK00077 320388010138 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 320388010139 dimer interface [polypeptide binding]; other site 320388010140 metal binding site [ion binding]; metal-binding site 320388010141 substrate binding pocket [chemical binding]; other site 320388010142 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 320388010143 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320388010144 CTP synthetase; Validated; Region: pyrG; PRK05380 320388010145 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 320388010146 Catalytic site [active] 320388010147 active site 320388010148 UTP binding site [chemical binding]; other site 320388010149 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 320388010150 active site 320388010151 putative oxyanion hole; other site 320388010152 catalytic triad [active] 320388010153 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320388010154 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 320388010155 nucleophilic elbow; other site 320388010156 catalytic triad; other site 320388010157 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 320388010158 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 320388010159 Competence protein; Region: Competence; pfam03772 320388010160 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 320388010161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320388010162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 320388010163 active site 320388010164 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 320388010165 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320388010166 Walker A/P-loop; other site 320388010167 ATP binding site [chemical binding]; other site 320388010168 Q-loop/lid; other site 320388010169 ABC transporter signature motif; other site 320388010170 Walker B; other site 320388010171 D-loop; other site 320388010172 H-loop/switch region; other site 320388010173 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 320388010174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320388010175 FtsX-like permease family; Region: FtsX; pfam02687 320388010176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 320388010177 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 320388010178 DHH family; Region: DHH; pfam01368 320388010179 DHHA1 domain; Region: DHHA1; pfam02272 320388010180 This domain is found in peptide chain release factors; Region: PCRF; smart00937 320388010181 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 320388010182 RF-1 domain; Region: RF-1; pfam00472 320388010183 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 320388010184 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 320388010185 dimer interface [polypeptide binding]; other site 320388010186 putative anticodon binding site; other site 320388010187 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 320388010188 motif 1; other site 320388010189 active site 320388010190 motif 2; other site 320388010191 motif 3; other site 320388010192 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 320388010193 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 320388010194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388010195 catalytic loop [active] 320388010196 iron binding site [ion binding]; other site 320388010197 chaperone protein HscA; Provisional; Region: hscA; PRK05183 320388010198 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 320388010199 nucleotide binding site [chemical binding]; other site 320388010200 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320388010201 SBD interface [polypeptide binding]; other site 320388010202 co-chaperone HscB; Provisional; Region: hscB; PRK03578 320388010203 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320388010204 HSP70 interaction site [polypeptide binding]; other site 320388010205 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 320388010206 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 320388010207 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 320388010208 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 320388010209 trimerization site [polypeptide binding]; other site 320388010210 active site 320388010211 cysteine desulfurase; Provisional; Region: PRK14012 320388010212 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 320388010213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388010214 catalytic residue [active] 320388010215 Predicted transcriptional regulator [Transcription]; Region: COG1959 320388010216 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 320388010217 Low molecular weight phosphatase family; Region: LMWPc; cd00115 320388010218 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 320388010219 active site 320388010220 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 320388010221 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 320388010222 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 320388010223 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 320388010224 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320388010225 Cysteine-rich domain; Region: CCG; pfam02754 320388010226 Cysteine-rich domain; Region: CCG; pfam02754 320388010227 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320388010228 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320388010229 Bacterial transcriptional regulator; Region: IclR; pfam01614 320388010230 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010231 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010232 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010233 Phasin protein; Region: Phasin_2; pfam09361 320388010234 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320388010235 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320388010236 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010238 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320388010240 E3 interaction surface; other site 320388010241 lipoyl attachment site [posttranslational modification]; other site 320388010242 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 320388010243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388010244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388010245 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320388010246 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 320388010247 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320388010248 E3 interaction surface; other site 320388010249 lipoyl attachment site [posttranslational modification]; other site 320388010250 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320388010251 E3 interaction surface; other site 320388010252 lipoyl attachment site [posttranslational modification]; other site 320388010253 e3 binding domain; Region: E3_binding; pfam02817 320388010254 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320388010255 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 320388010256 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 320388010257 dimer interface [polypeptide binding]; other site 320388010258 TPP-binding site [chemical binding]; other site 320388010259 PAS domain S-box; Region: sensory_box; TIGR00229 320388010260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388010261 putative active site [active] 320388010262 heme pocket [chemical binding]; other site 320388010263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388010264 dimer interface [polypeptide binding]; other site 320388010265 phosphorylation site [posttranslational modification] 320388010266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388010267 ATP binding site [chemical binding]; other site 320388010268 Mg2+ binding site [ion binding]; other site 320388010269 G-X-G motif; other site 320388010270 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 320388010271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388010272 active site 320388010273 phosphorylation site [posttranslational modification] 320388010274 intermolecular recognition site; other site 320388010275 dimerization interface [polypeptide binding]; other site 320388010276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388010277 DNA binding residues [nucleotide binding] 320388010278 dimerization interface [polypeptide binding]; other site 320388010279 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 320388010280 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 320388010281 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 320388010282 homodimer interface [polypeptide binding]; other site 320388010283 NADP binding site [chemical binding]; other site 320388010284 substrate binding site [chemical binding]; other site 320388010285 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 320388010286 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 320388010287 active site 320388010288 Zn binding site [ion binding]; other site 320388010289 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 320388010290 active site 320388010291 DNA polymerase IV; Validated; Region: PRK02406 320388010292 DNA binding site [nucleotide binding] 320388010293 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 320388010294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388010295 putative substrate translocation pore; other site 320388010296 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 320388010297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388010298 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 320388010299 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 320388010300 [4Fe-4S] binding site [ion binding]; other site 320388010301 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388010302 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388010303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320388010304 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 320388010305 molybdopterin cofactor binding site; other site 320388010306 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 320388010307 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 320388010308 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 320388010309 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 320388010310 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 320388010311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388010312 dimerization interface [polypeptide binding]; other site 320388010313 GAF domain; Region: GAF; pfam01590 320388010314 Histidine kinase; Region: HisKA_3; pfam07730 320388010315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388010316 ATP binding site [chemical binding]; other site 320388010317 Mg2+ binding site [ion binding]; other site 320388010318 G-X-G motif; other site 320388010319 transcriptional regulator NarL; Provisional; Region: PRK10651 320388010320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388010321 active site 320388010322 phosphorylation site [posttranslational modification] 320388010323 intermolecular recognition site; other site 320388010324 dimerization interface [polypeptide binding]; other site 320388010325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388010326 DNA binding residues [nucleotide binding] 320388010327 dimerization interface [polypeptide binding]; other site 320388010328 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 320388010329 putative catalytic site [active] 320388010330 putative phosphate binding site [ion binding]; other site 320388010331 active site 320388010332 metal binding site A [ion binding]; metal-binding site 320388010333 DNA binding site [nucleotide binding] 320388010334 putative AP binding site [nucleotide binding]; other site 320388010335 putative metal binding site B [ion binding]; other site 320388010336 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010337 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010338 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010339 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 320388010340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388010341 active site 320388010342 phosphorylation site [posttranslational modification] 320388010343 intermolecular recognition site; other site 320388010344 dimerization interface [polypeptide binding]; other site 320388010345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388010346 Walker A motif; other site 320388010347 ATP binding site [chemical binding]; other site 320388010348 Walker B motif; other site 320388010349 arginine finger; other site 320388010350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388010351 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 320388010352 PAS domain; Region: PAS; smart00091 320388010353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388010354 dimer interface [polypeptide binding]; other site 320388010355 phosphorylation site [posttranslational modification] 320388010356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388010357 ATP binding site [chemical binding]; other site 320388010358 Mg2+ binding site [ion binding]; other site 320388010359 G-X-G motif; other site 320388010360 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010362 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010363 glutamine synthetase; Provisional; Region: glnA; PRK09469 320388010364 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 320388010365 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320388010366 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 320388010367 active site residue [active] 320388010368 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 320388010369 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 320388010370 putative MPT binding site; other site 320388010371 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 320388010372 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 320388010373 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 320388010374 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 320388010375 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 320388010376 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 320388010377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388010378 ATP binding site [chemical binding]; other site 320388010379 putative Mg++ binding site [ion binding]; other site 320388010380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388010381 nucleotide binding region [chemical binding]; other site 320388010382 ATP-binding site [chemical binding]; other site 320388010383 Helicase associated domain (HA2); Region: HA2; pfam04408 320388010384 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 320388010385 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 320388010386 N-acetylglutamate synthase; Validated; Region: PRK05279 320388010387 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 320388010388 putative feedback inhibition sensing region; other site 320388010389 putative nucleotide binding site [chemical binding]; other site 320388010390 putative substrate binding site [chemical binding]; other site 320388010391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388010392 Coenzyme A binding pocket [chemical binding]; other site 320388010393 oxidative damage protection protein; Provisional; Region: PRK05408 320388010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388010395 metabolite-proton symporter; Region: 2A0106; TIGR00883 320388010396 putative substrate translocation pore; other site 320388010397 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388010398 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388010399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388010400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388010401 active site 320388010402 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320388010403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388010404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388010405 dimerization interface [polypeptide binding]; other site 320388010406 HTH-like domain; Region: HTH_21; pfam13276 320388010407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388010408 Integrase core domain; Region: rve; pfam00665 320388010409 Integrase core domain; Region: rve_3; pfam13683 320388010410 Transposase; Region: HTH_Tnp_1; pfam01527 320388010411 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388010412 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388010413 trimer interface [polypeptide binding]; other site 320388010414 eyelet of channel; other site 320388010415 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 320388010416 Nitrogen regulatory protein P-II; Region: P-II; smart00938 320388010417 NAD synthetase; Provisional; Region: PRK13981 320388010418 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 320388010419 multimer interface [polypeptide binding]; other site 320388010420 active site 320388010421 catalytic triad [active] 320388010422 protein interface 1 [polypeptide binding]; other site 320388010423 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 320388010424 homodimer interface [polypeptide binding]; other site 320388010425 NAD binding pocket [chemical binding]; other site 320388010426 ATP binding pocket [chemical binding]; other site 320388010427 Mg binding site [ion binding]; other site 320388010428 active-site loop [active] 320388010429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 320388010430 Protein of unknown function, DUF482; Region: DUF482; pfam04339 320388010431 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 320388010432 GIY-YIG motif/motif A; other site 320388010433 putative active site [active] 320388010434 putative metal binding site [ion binding]; other site 320388010435 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 320388010436 dimer interface [polypeptide binding]; other site 320388010437 substrate binding site [chemical binding]; other site 320388010438 metal binding sites [ion binding]; metal-binding site 320388010439 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388010440 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 320388010441 NAD(P) binding site [chemical binding]; other site 320388010442 catalytic residues [active] 320388010443 catalytic residues [active] 320388010444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388010445 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 320388010446 NAD(P) binding site [chemical binding]; other site 320388010447 active site 320388010448 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 320388010449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388010450 putative substrate translocation pore; other site 320388010451 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 320388010452 HemY protein N-terminus; Region: HemY_N; pfam07219 320388010453 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 320388010454 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 320388010455 active site 320388010456 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 320388010457 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 320388010458 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 320388010459 domain interfaces; other site 320388010460 active site 320388010461 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 320388010462 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 320388010463 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010465 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388010467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388010468 S-adenosylmethionine binding site [chemical binding]; other site 320388010469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388010470 sequence-specific DNA binding site [nucleotide binding]; other site 320388010471 salt bridge; other site 320388010472 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388010473 Spore Coat Protein U domain; Region: SCPU; pfam05229 320388010474 Uncharacterized secreted protein [Function unknown]; Region: COG5430 320388010475 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320388010476 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320388010477 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320388010478 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320388010479 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320388010480 PapC C-terminal domain; Region: PapC_C; pfam13953 320388010481 argininosuccinate lyase; Provisional; Region: PRK00855 320388010482 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320388010483 active sites [active] 320388010484 tetramer interface [polypeptide binding]; other site 320388010485 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320388010486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388010487 motif II; other site 320388010488 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 320388010489 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 320388010490 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 320388010491 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 320388010492 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320388010493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388010494 catalytic residue [active] 320388010495 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 320388010496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320388010497 trimer interface [polypeptide binding]; other site 320388010498 active site 320388010499 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 320388010500 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 320388010501 E-class dimer interface [polypeptide binding]; other site 320388010502 P-class dimer interface [polypeptide binding]; other site 320388010503 active site 320388010504 Cu2+ binding site [ion binding]; other site 320388010505 Zn2+ binding site [ion binding]; other site 320388010506 Domain of unknown function DUF59; Region: DUF59; pfam01883 320388010507 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 320388010508 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320388010509 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388010510 ligand binding site [chemical binding]; other site 320388010511 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 320388010512 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 320388010513 active site 320388010514 HIGH motif; other site 320388010515 KMSKS motif; other site 320388010516 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 320388010517 tRNA binding surface [nucleotide binding]; other site 320388010518 anticodon binding site; other site 320388010519 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 320388010520 dimer interface [polypeptide binding]; other site 320388010521 putative tRNA-binding site [nucleotide binding]; other site 320388010522 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 320388010523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388010524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 320388010525 Family of unknown function (DUF490); Region: DUF490; pfam04357 320388010526 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 320388010527 Surface antigen; Region: Bac_surface_Ag; pfam01103 320388010528 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 320388010529 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 320388010530 pantoate--beta-alanine ligase; Region: panC; TIGR00018 320388010531 Pantoate-beta-alanine ligase; Region: PanC; cd00560 320388010532 active site 320388010533 ATP-binding site [chemical binding]; other site 320388010534 pantoate-binding site; other site 320388010535 HXXH motif; other site 320388010536 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 320388010537 tetramerization interface [polypeptide binding]; other site 320388010538 active site 320388010539 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 320388010540 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320388010541 P-loop; other site 320388010542 Magnesium ion binding site [ion binding]; other site 320388010543 DoxX; Region: DoxX; pfam07681 320388010544 cobyric acid synthase; Provisional; Region: PRK00784 320388010545 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 320388010546 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 320388010547 catalytic triad [active] 320388010548 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 320388010549 homotrimer interface [polypeptide binding]; other site 320388010550 Walker A motif; other site 320388010551 GTP binding site [chemical binding]; other site 320388010552 Walker B motif; other site 320388010553 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 320388010554 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 320388010555 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 320388010556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388010557 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 320388010558 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 320388010559 cobalamin binding residues [chemical binding]; other site 320388010560 putative BtuC binding residues; other site 320388010561 dimer interface [polypeptide binding]; other site 320388010562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320388010563 catalytic core [active] 320388010564 cobalamin synthase; Reviewed; Region: cobS; PRK00235 320388010565 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 320388010566 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 320388010567 putative dimer interface [polypeptide binding]; other site 320388010568 active site pocket [active] 320388010569 putative cataytic base [active] 320388010570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320388010571 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320388010572 Walker A/P-loop; other site 320388010573 ATP binding site [chemical binding]; other site 320388010574 Q-loop/lid; other site 320388010575 ABC transporter signature motif; other site 320388010576 Walker B; other site 320388010577 D-loop; other site 320388010578 H-loop/switch region; other site 320388010579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320388010580 ABC-ATPase subunit interface; other site 320388010581 dimer interface [polypeptide binding]; other site 320388010582 putative PBP binding regions; other site 320388010583 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 320388010584 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388010585 N-terminal plug; other site 320388010586 ligand-binding site [chemical binding]; other site 320388010587 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 320388010588 Cell division protein ZapA; Region: ZapA; pfam05164 320388010589 Uncharacterized conserved protein [Function unknown]; Region: COG2947 320388010590 Protein of unknown function (DUF541); Region: SIMPL; cl01077 320388010591 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 320388010592 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 320388010593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388010594 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 320388010595 putative dimerization interface [polypeptide binding]; other site 320388010596 putative substrate binding pocket [chemical binding]; other site 320388010597 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 320388010598 Transposase domain (DUF772); Region: DUF772; pfam05598 320388010599 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388010600 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388010601 Cytochrome c; Region: Cytochrom_C; cl11414 320388010602 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 320388010603 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 320388010604 multifunctional aminopeptidase A; Provisional; Region: PRK00913 320388010605 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 320388010606 interface (dimer of trimers) [polypeptide binding]; other site 320388010607 Substrate-binding/catalytic site; other site 320388010608 Zn-binding sites [ion binding]; other site 320388010609 Predicted permeases [General function prediction only]; Region: COG0795 320388010610 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 320388010611 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 320388010612 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 320388010613 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 320388010614 putative active site [active] 320388010615 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 320388010616 active site 320388010617 SAM binding site [chemical binding]; other site 320388010618 homodimer interface [polypeptide binding]; other site 320388010619 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 320388010620 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 320388010621 CysD dimerization site [polypeptide binding]; other site 320388010622 G1 box; other site 320388010623 putative GEF interaction site [polypeptide binding]; other site 320388010624 GTP/Mg2+ binding site [chemical binding]; other site 320388010625 Switch I region; other site 320388010626 G2 box; other site 320388010627 G3 box; other site 320388010628 Switch II region; other site 320388010629 G4 box; other site 320388010630 G5 box; other site 320388010631 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 320388010632 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 320388010633 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 320388010634 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320388010635 Active Sites [active] 320388010636 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 320388010637 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320388010638 Active Sites [active] 320388010639 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 320388010640 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 320388010641 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388010642 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320388010643 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 320388010644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388010645 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 320388010646 substrate binding site [chemical binding]; other site 320388010647 dimerization interface [polypeptide binding]; other site 320388010648 Transposase; Region: HTH_Tnp_1; pfam01527 320388010649 HTH-like domain; Region: HTH_21; pfam13276 320388010650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388010651 Integrase core domain; Region: rve; pfam00665 320388010652 Integrase core domain; Region: rve_3; pfam13683 320388010653 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 320388010654 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320388010655 Peptidase C26; Region: Peptidase_C26; pfam07722 320388010656 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 320388010657 catalytic triad [active] 320388010658 N-formylglutamate amidohydrolase; Region: FGase; cl01522 320388010659 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 320388010660 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 320388010661 active site 320388010662 imidazolonepropionase; Validated; Region: PRK09356 320388010663 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 320388010664 active site 320388010665 HutD; Region: HutD; pfam05962 320388010666 urocanate hydratase; Provisional; Region: PRK05414 320388010667 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 320388010668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320388010669 DNA-binding site [nucleotide binding]; DNA binding site 320388010670 UTRA domain; Region: UTRA; pfam07702 320388010671 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 320388010672 active sites [active] 320388010673 tetramer interface [polypeptide binding]; other site 320388010674 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 320388010675 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 320388010676 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 320388010677 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320388010678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388010679 DNA binding residues [nucleotide binding] 320388010680 dimerization interface [polypeptide binding]; other site 320388010681 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320388010682 ligand-binding site [chemical binding]; other site 320388010683 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 320388010684 DNA photolyase; Region: DNA_photolyase; pfam00875 320388010685 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 320388010686 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320388010687 Di-iron ligands [ion binding]; other site 320388010688 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 320388010689 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 320388010690 NnrS protein; Region: NnrS; pfam05940 320388010691 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 320388010692 Class III ribonucleotide reductase; Region: RNR_III; cd01675 320388010693 effector binding site; other site 320388010694 active site 320388010695 Zn binding site [ion binding]; other site 320388010696 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 320388010697 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 320388010698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388010699 FeS/SAM binding site; other site 320388010700 DGC domain; Region: DGC; pfam08859 320388010701 SCP-2 sterol transfer family; Region: SCP2; cl01225 320388010702 putative protease; Provisional; Region: PRK15447 320388010703 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 320388010704 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 320388010705 Peptidase family U32; Region: Peptidase_U32; pfam01136 320388010706 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 320388010707 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320388010708 FMN binding site [chemical binding]; other site 320388010709 substrate binding site [chemical binding]; other site 320388010710 putative catalytic residue [active] 320388010711 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320388010712 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320388010713 ligand binding site [chemical binding]; other site 320388010714 flexible hinge region; other site 320388010715 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320388010716 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 320388010717 HemN C-terminal domain; Region: HemN_C; pfam06969 320388010718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388010719 dimerization interface [polypeptide binding]; other site 320388010720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388010721 dimer interface [polypeptide binding]; other site 320388010722 putative CheW interface [polypeptide binding]; other site 320388010723 NnrS protein; Region: NnrS; pfam05940 320388010724 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 320388010725 putative ABC transporter; Region: ycf24; CHL00085 320388010726 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 320388010727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388010728 Walker A/P-loop; other site 320388010729 ATP binding site [chemical binding]; other site 320388010730 ABC transporter signature motif; other site 320388010731 Walker B; other site 320388010732 D-loop; other site 320388010733 H-loop/switch region; other site 320388010734 FeS assembly protein SufD; Region: sufD; TIGR01981 320388010735 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 320388010736 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 320388010737 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 320388010738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388010739 catalytic residue [active] 320388010740 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 320388010741 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 320388010742 trimerization site [polypeptide binding]; other site 320388010743 active site 320388010744 Domain of unknown function DUF59; Region: DUF59; cl00941 320388010745 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 320388010746 Transcriptional regulator; Region: Rrf2; cl17282 320388010747 Rrf2 family protein; Region: rrf2_super; TIGR00738 320388010748 Hemerythrin; Region: Hemerythrin; cd12107 320388010749 Fe binding site [ion binding]; other site 320388010750 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 320388010751 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320388010752 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 320388010753 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320388010754 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 320388010755 D-pathway; other site 320388010756 Putative water exit pathway; other site 320388010757 Binuclear center (heme o3/CuB) [ion binding]; other site 320388010758 K-pathway; other site 320388010759 Putative proton exit pathway; other site 320388010760 Low-spin heme (heme b) binding site [chemical binding]; other site 320388010761 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 320388010762 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 320388010763 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320388010764 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 320388010765 putative di-iron ligands [ion binding]; other site 320388010766 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320388010767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388010768 substrate binding pocket [chemical binding]; other site 320388010769 membrane-bound complex binding site; other site 320388010770 hinge residues; other site 320388010771 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 320388010772 dimer interface [polypeptide binding]; other site 320388010773 N-terminal domain interface [polypeptide binding]; other site 320388010774 substrate binding pocket (H-site) [chemical binding]; other site 320388010775 succinylglutamate desuccinylase; Provisional; Region: PRK05324 320388010776 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 320388010777 active site 320388010778 Zn binding site [ion binding]; other site 320388010779 succinylarginine dihydrolase; Provisional; Region: PRK13281 320388010780 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 320388010781 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 320388010782 NAD(P) binding site [chemical binding]; other site 320388010783 catalytic residues [active] 320388010784 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 320388010785 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 320388010786 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 320388010787 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 320388010788 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 320388010789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388010790 inhibitor-cofactor binding pocket; inhibition site 320388010791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388010792 catalytic residue [active] 320388010793 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320388010794 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320388010795 conserved cys residue [active] 320388010796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388010797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388010798 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320388010799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320388010800 Walker A/P-loop; other site 320388010801 ATP binding site [chemical binding]; other site 320388010802 Q-loop/lid; other site 320388010803 ABC transporter signature motif; other site 320388010804 Walker B; other site 320388010805 D-loop; other site 320388010806 H-loop/switch region; other site 320388010807 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320388010808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388010809 dimer interface [polypeptide binding]; other site 320388010810 conserved gate region; other site 320388010811 putative PBP binding loops; other site 320388010812 ABC-ATPase subunit interface; other site 320388010813 Transposase; Region: HTH_Tnp_1; pfam01527 320388010814 HTH-like domain; Region: HTH_21; pfam13276 320388010815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388010816 Integrase core domain; Region: rve; pfam00665 320388010817 Integrase core domain; Region: rve_3; pfam13683 320388010818 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320388010819 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320388010820 dimerization interface [polypeptide binding]; other site 320388010821 ligand binding site [chemical binding]; other site 320388010822 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320388010823 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 320388010824 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320388010825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388010826 putative ADP-binding pocket [chemical binding]; other site 320388010827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320388010828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320388010829 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320388010830 Walker A/P-loop; other site 320388010831 ATP binding site [chemical binding]; other site 320388010832 Q-loop/lid; other site 320388010833 ABC transporter signature motif; other site 320388010834 Walker B; other site 320388010835 D-loop; other site 320388010836 H-loop/switch region; other site 320388010837 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 320388010838 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 320388010839 active site 320388010840 homotetramer interface [polypeptide binding]; other site 320388010841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388010842 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 320388010843 active site 320388010844 motif I; other site 320388010845 motif II; other site 320388010846 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320388010847 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320388010848 Cu(I) binding site [ion binding]; other site 320388010849 Protein of unknown function (DUF461); Region: DUF461; pfam04314 320388010850 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 320388010851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388010852 Pirin-related protein [General function prediction only]; Region: COG1741 320388010853 Pirin; Region: Pirin; pfam02678 320388010854 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 320388010855 LysR family transcriptional regulator; Provisional; Region: PRK14997 320388010856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388010857 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 320388010858 putative effector binding pocket; other site 320388010859 putative dimerization interface [polypeptide binding]; other site 320388010860 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 320388010861 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 320388010862 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 320388010863 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 320388010864 GIY-YIG motif/motif A; other site 320388010865 active site 320388010866 catalytic site [active] 320388010867 putative DNA binding site [nucleotide binding]; other site 320388010868 metal binding site [ion binding]; metal-binding site 320388010869 UvrB/uvrC motif; Region: UVR; pfam02151 320388010870 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 320388010871 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 320388010872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 320388010873 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 320388010874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 320388010875 elongation factor P; Validated; Region: PRK00529 320388010876 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 320388010877 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 320388010878 RNA binding site [nucleotide binding]; other site 320388010879 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 320388010880 RNA binding site [nucleotide binding]; other site 320388010881 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388010882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388010883 active site 320388010884 phosphorylation site [posttranslational modification] 320388010885 intermolecular recognition site; other site 320388010886 dimerization interface [polypeptide binding]; other site 320388010887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388010888 Walker A motif; other site 320388010889 ATP binding site [chemical binding]; other site 320388010890 Walker B motif; other site 320388010891 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388010892 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320388010893 beta-hexosaminidase; Provisional; Region: PRK05337 320388010894 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 320388010895 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 320388010896 active site 320388010897 hydrophilic channel; other site 320388010898 dimerization interface [polypeptide binding]; other site 320388010899 catalytic residues [active] 320388010900 active site lid [active] 320388010901 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 320388010902 Recombination protein O N terminal; Region: RecO_N; pfam11967 320388010903 Recombination protein O C terminal; Region: RecO_C; pfam02565 320388010904 GTPase Era; Reviewed; Region: era; PRK00089 320388010905 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 320388010906 G1 box; other site 320388010907 GTP/Mg2+ binding site [chemical binding]; other site 320388010908 Switch I region; other site 320388010909 G2 box; other site 320388010910 Switch II region; other site 320388010911 G3 box; other site 320388010912 G4 box; other site 320388010913 G5 box; other site 320388010914 KH domain; Region: KH_2; pfam07650 320388010915 ribonuclease III; Provisional; Region: PRK14718 320388010916 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 320388010917 dimerization interface [polypeptide binding]; other site 320388010918 active site 320388010919 metal binding site [ion binding]; metal-binding site 320388010920 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 320388010921 signal peptidase I; Provisional; Region: PRK10861 320388010922 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320388010923 Catalytic site [active] 320388010924 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320388010925 GTP-binding protein LepA; Provisional; Region: PRK05433 320388010926 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 320388010927 G1 box; other site 320388010928 putative GEF interaction site [polypeptide binding]; other site 320388010929 GTP/Mg2+ binding site [chemical binding]; other site 320388010930 Switch I region; other site 320388010931 G2 box; other site 320388010932 G3 box; other site 320388010933 Switch II region; other site 320388010934 G4 box; other site 320388010935 G5 box; other site 320388010936 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 320388010937 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 320388010938 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 320388010939 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 320388010940 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320388010941 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320388010942 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388010943 protein binding site [polypeptide binding]; other site 320388010944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388010945 protein binding site [polypeptide binding]; other site 320388010946 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 320388010947 anti-sigma E factor; Provisional; Region: rseB; PRK09455 320388010948 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 320388010949 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 320388010950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388010951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388010952 DNA binding residues [nucleotide binding] 320388010953 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 320388010954 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 320388010955 dimer interface [polypeptide binding]; other site 320388010956 active site 320388010957 acyl carrier protein; Provisional; Region: acpP; PRK00982 320388010958 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320388010959 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 320388010960 NAD(P) binding site [chemical binding]; other site 320388010961 homotetramer interface [polypeptide binding]; other site 320388010962 homodimer interface [polypeptide binding]; other site 320388010963 active site 320388010964 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320388010965 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320388010966 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320388010967 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320388010968 dimer interface [polypeptide binding]; other site 320388010969 active site 320388010970 CoA binding pocket [chemical binding]; other site 320388010971 putative phosphate acyltransferase; Provisional; Region: PRK05331 320388010972 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 320388010973 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 320388010974 Maf-like protein; Region: Maf; pfam02545 320388010975 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 320388010976 active site 320388010977 dimer interface [polypeptide binding]; other site 320388010978 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 320388010979 putative SAM binding site [chemical binding]; other site 320388010980 homodimer interface [polypeptide binding]; other site 320388010981 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 320388010982 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 320388010983 tandem repeat interface [polypeptide binding]; other site 320388010984 oligomer interface [polypeptide binding]; other site 320388010985 active site residues [active] 320388010986 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 320388010987 iron-sulfur cluster [ion binding]; other site 320388010988 [2Fe-2S] cluster binding site [ion binding]; other site 320388010989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 320388010990 motif I; other site 320388010991 active site 320388010992 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 320388010993 S4 domain; Region: S4; pfam01479 320388010994 RNA binding surface [nucleotide binding]; other site 320388010995 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320388010996 active site 320388010997 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 320388010998 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 320388010999 homodimer interface [polypeptide binding]; other site 320388011000 oligonucleotide binding site [chemical binding]; other site 320388011001 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 320388011002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388011003 FeS/SAM binding site; other site 320388011004 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 320388011005 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 320388011006 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 320388011007 GTP binding site; other site 320388011008 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 320388011009 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 320388011010 dimer interface [polypeptide binding]; other site 320388011011 putative functional site; other site 320388011012 putative MPT binding site; other site 320388011013 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320388011014 RmuC family; Region: RmuC; pfam02646 320388011015 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 320388011016 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320388011017 dimerization interface [polypeptide binding]; other site 320388011018 ligand binding site [chemical binding]; other site 320388011019 NADP binding site [chemical binding]; other site 320388011020 catalytic site [active] 320388011021 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 320388011022 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 320388011023 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 320388011024 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 320388011025 active site 320388011026 Ferredoxin [Energy production and conversion]; Region: COG1146 320388011027 4Fe-4S binding domain; Region: Fer4; pfam00037 320388011028 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 320388011029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 320388011030 CreA protein; Region: CreA; pfam05981 320388011031 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 320388011032 S4 domain; Region: S4_2; pfam13275 320388011033 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 320388011034 multidrug efflux protein; Reviewed; Region: PRK01766 320388011035 cation binding site [ion binding]; other site 320388011036 Transposase; Region: HTH_Tnp_1; pfam01527 320388011037 HTH-like domain; Region: HTH_21; pfam13276 320388011038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011039 Integrase core domain; Region: rve; pfam00665 320388011040 Integrase core domain; Region: rve_3; pfam13683 320388011041 fumarate hydratase; Reviewed; Region: fumC; PRK00485 320388011042 Class II fumarases; Region: Fumarase_classII; cd01362 320388011043 active site 320388011044 tetramer interface [polypeptide binding]; other site 320388011045 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 320388011046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388011047 dimerization interface [polypeptide binding]; other site 320388011048 putative DNA binding site [nucleotide binding]; other site 320388011049 putative Zn2+ binding site [ion binding]; other site 320388011050 FecR protein; Region: FecR; pfam04773 320388011051 Transposase domain (DUF772); Region: DUF772; pfam05598 320388011052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388011053 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388011054 thymidylate synthase; Provisional; Region: thyA; PRK13821 320388011055 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 320388011056 dimerization interface [polypeptide binding]; other site 320388011057 active site 320388011058 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388011059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388011060 Walker A motif; other site 320388011061 ATP binding site [chemical binding]; other site 320388011062 Walker B motif; other site 320388011063 arginine finger; other site 320388011064 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388011065 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388011066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388011067 Walker A motif; other site 320388011068 ATP binding site [chemical binding]; other site 320388011069 Walker B motif; other site 320388011070 arginine finger; other site 320388011071 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320388011072 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 320388011073 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 320388011074 folate binding site [chemical binding]; other site 320388011075 NADP+ binding site [chemical binding]; other site 320388011076 Transposase domain (DUF772); Region: DUF772; pfam05598 320388011077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388011078 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388011079 peptidase PmbA; Provisional; Region: PRK11040 320388011080 hypothetical protein; Provisional; Region: PRK05255 320388011081 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 320388011082 MPT binding site; other site 320388011083 trimer interface [polypeptide binding]; other site 320388011084 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 320388011085 catalytic site [active] 320388011086 putative active site [active] 320388011087 putative substrate binding site [chemical binding]; other site 320388011088 dimer interface [polypeptide binding]; other site 320388011089 Peptidase family M48; Region: Peptidase_M48; pfam01435 320388011090 GTPase RsgA; Reviewed; Region: PRK00098 320388011091 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 320388011092 RNA binding site [nucleotide binding]; other site 320388011093 homodimer interface [polypeptide binding]; other site 320388011094 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 320388011095 GTPase/Zn-binding domain interface [polypeptide binding]; other site 320388011096 GTP/Mg2+ binding site [chemical binding]; other site 320388011097 G4 box; other site 320388011098 G5 box; other site 320388011099 G1 box; other site 320388011100 Switch I region; other site 320388011101 G2 box; other site 320388011102 G3 box; other site 320388011103 Switch II region; other site 320388011104 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 320388011105 CobD/CbiB family protein; Provisional; Region: PRK07630 320388011106 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 320388011107 putative active site [active] 320388011108 putative CoA binding site [chemical binding]; other site 320388011109 nudix motif; other site 320388011110 metal binding site [ion binding]; metal-binding site 320388011111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388011112 Coenzyme A binding pocket [chemical binding]; other site 320388011113 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 320388011114 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 320388011115 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 320388011116 RimM N-terminal domain; Region: RimM; pfam01782 320388011117 PRC-barrel domain; Region: PRC; pfam05239 320388011118 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 320388011119 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 320388011120 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 320388011121 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 320388011122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388011123 FeS/SAM binding site; other site 320388011124 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 320388011125 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320388011126 AsnC family; Region: AsnC_trans_reg; pfam01037 320388011127 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320388011128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388011129 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320388011130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388011131 active site 320388011132 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320388011133 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320388011134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388011135 active site 320388011136 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 320388011137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 320388011138 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 320388011139 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 320388011140 Ligand binding site [chemical binding]; other site 320388011141 Electron transfer flavoprotein domain; Region: ETF; pfam01012 320388011142 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 320388011143 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320388011144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388011145 dimer interface [polypeptide binding]; other site 320388011146 conserved gate region; other site 320388011147 ABC-ATPase subunit interface; other site 320388011148 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 320388011149 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 320388011150 Walker A/P-loop; other site 320388011151 ATP binding site [chemical binding]; other site 320388011152 Q-loop/lid; other site 320388011153 ABC transporter signature motif; other site 320388011154 Walker B; other site 320388011155 D-loop; other site 320388011156 H-loop/switch region; other site 320388011157 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 320388011158 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 320388011159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320388011160 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320388011161 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 320388011162 putative active site [active] 320388011163 Zn binding site [ion binding]; other site 320388011164 Transglycosylase SLT domain; Region: SLT_2; pfam13406 320388011165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320388011166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320388011167 catalytic residue [active] 320388011168 cysteine synthase B; Region: cysM; TIGR01138 320388011169 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320388011170 dimer interface [polypeptide binding]; other site 320388011171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388011172 catalytic residue [active] 320388011173 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 320388011174 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 320388011175 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 320388011176 NADP binding site [chemical binding]; other site 320388011177 homopentamer interface [polypeptide binding]; other site 320388011178 substrate binding site [chemical binding]; other site 320388011179 active site 320388011180 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 320388011181 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388011182 putative ribose interaction site [chemical binding]; other site 320388011183 putative ADP binding site [chemical binding]; other site 320388011184 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 320388011185 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320388011186 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 320388011187 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 320388011188 tetratricopeptide repeat protein; Provisional; Region: PRK11788 320388011189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388011190 binding surface 320388011191 TPR motif; other site 320388011192 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 320388011193 Transposase domain (DUF772); Region: DUF772; pfam05598 320388011194 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388011195 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388011196 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320388011197 IHF dimer interface [polypeptide binding]; other site 320388011198 IHF - DNA interface [nucleotide binding]; other site 320388011199 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 320388011200 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 320388011201 RNA binding site [nucleotide binding]; other site 320388011202 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 320388011203 RNA binding site [nucleotide binding]; other site 320388011204 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 320388011205 RNA binding site [nucleotide binding]; other site 320388011206 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 320388011207 RNA binding site [nucleotide binding]; other site 320388011208 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 320388011209 RNA binding site [nucleotide binding]; other site 320388011210 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 320388011211 RNA binding site [nucleotide binding]; other site 320388011212 cytidylate kinase; Provisional; Region: cmk; PRK00023 320388011213 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 320388011214 CMP-binding site; other site 320388011215 The sites determining sugar specificity; other site 320388011216 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 320388011217 prephenate dehydrogenase; Validated; Region: PRK08507 320388011218 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 320388011219 hinge; other site 320388011220 active site 320388011221 Chorismate mutase type II; Region: CM_2; smart00830 320388011222 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 320388011223 Prephenate dehydratase; Region: PDT; pfam00800 320388011224 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 320388011225 putative L-Phe binding site [chemical binding]; other site 320388011226 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 320388011227 homodimer interface [polypeptide binding]; other site 320388011228 substrate-cofactor binding pocket; other site 320388011229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388011230 catalytic residue [active] 320388011231 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 320388011232 DNA gyrase subunit A; Validated; Region: PRK05560 320388011233 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 320388011234 CAP-like domain; other site 320388011235 active site 320388011236 primary dimer interface [polypeptide binding]; other site 320388011237 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011241 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011242 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320388011243 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388011244 ligand binding site [chemical binding]; other site 320388011245 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 320388011246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388011247 S-adenosylmethionine binding site [chemical binding]; other site 320388011248 phosphoglycolate phosphatase; Provisional; Region: PRK13226 320388011249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388011250 motif II; other site 320388011251 HTH-like domain; Region: HTH_21; pfam13276 320388011252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011253 Integrase core domain; Region: rve; pfam00665 320388011254 Integrase core domain; Region: rve_3; pfam13683 320388011255 Transposase; Region: HTH_Tnp_1; pfam01527 320388011256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388011257 S-adenosylmethionine binding site [chemical binding]; other site 320388011258 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 320388011259 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 320388011260 PBP superfamily domain; Region: PBP_like; pfam12727 320388011261 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 320388011262 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 320388011263 putative dimer interface [polypeptide binding]; other site 320388011264 [2Fe-2S] cluster binding site [ion binding]; other site 320388011265 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 320388011266 putative dimer interface [polypeptide binding]; other site 320388011267 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 320388011268 SLBB domain; Region: SLBB; pfam10531 320388011269 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 320388011270 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 320388011271 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388011272 catalytic loop [active] 320388011273 iron binding site [ion binding]; other site 320388011274 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 320388011275 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 320388011276 [4Fe-4S] binding site [ion binding]; other site 320388011277 molybdopterin cofactor binding site; other site 320388011278 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 320388011279 molybdopterin cofactor binding site; other site 320388011280 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 320388011281 hypothetical protein; Provisional; Region: PRK06184 320388011282 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320388011283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388011284 binding surface 320388011285 TPR motif; other site 320388011286 TPR repeat; Region: TPR_11; pfam13414 320388011287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388011288 binding surface 320388011289 TPR motif; other site 320388011290 TPR repeat; Region: TPR_11; pfam13414 320388011291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388011292 TPR repeat; Region: TPR_11; pfam13414 320388011293 TPR motif; other site 320388011294 binding surface 320388011295 TPR repeat; Region: TPR_11; pfam13414 320388011296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388011297 binding surface 320388011298 TPR motif; other site 320388011299 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388011300 citrate-proton symporter; Provisional; Region: PRK15075 320388011301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388011302 putative substrate translocation pore; other site 320388011303 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 320388011304 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 320388011305 catalytic triad [active] 320388011306 amidase; Provisional; Region: PRK07056 320388011307 Amidase; Region: Amidase; cl11426 320388011308 disulfide bond formation protein B; Provisional; Region: PRK02110 320388011309 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 320388011310 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 320388011311 XdhC Rossmann domain; Region: XdhC_C; pfam13478 320388011312 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 320388011313 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 320388011314 active site 320388011315 purine riboside binding site [chemical binding]; other site 320388011316 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 320388011317 guanine deaminase; Provisional; Region: PRK09228 320388011318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320388011319 active site 320388011320 Predicted membrane protein [Function unknown]; Region: COG2119 320388011321 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 320388011322 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 320388011323 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 320388011324 aminopeptidase N; Provisional; Region: pepN; PRK14015 320388011325 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 320388011326 active site 320388011327 Zn binding site [ion binding]; other site 320388011328 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 320388011329 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 320388011330 THF binding site; other site 320388011331 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 320388011332 substrate binding site [chemical binding]; other site 320388011333 THF binding site; other site 320388011334 zinc-binding site [ion binding]; other site 320388011335 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 320388011336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388011337 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 320388011338 putative dimerization interface [polypeptide binding]; other site 320388011339 fructose-1,6-bisphosphatase family protein; Region: PLN02628 320388011340 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 320388011341 AMP binding site [chemical binding]; other site 320388011342 metal binding site [ion binding]; metal-binding site 320388011343 active site 320388011344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388011345 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388011346 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 320388011347 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388011348 BNR repeat-like domain; Region: BNR_2; pfam13088 320388011349 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 320388011350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320388011351 N-terminal plug; other site 320388011352 ligand-binding site [chemical binding]; other site 320388011353 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 320388011354 chorismate mutase; Provisional; Region: PRK09269 320388011355 Chorismate mutase type II; Region: CM_2; cl00693 320388011356 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 320388011357 HTH-like domain; Region: HTH_21; pfam13276 320388011358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011359 Integrase core domain; Region: rve; pfam00665 320388011360 Integrase core domain; Region: rve_3; pfam13683 320388011361 Transposase; Region: HTH_Tnp_1; pfam01527 320388011362 HTH-like domain; Region: HTH_21; pfam13276 320388011363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011364 Integrase core domain; Region: rve; pfam00665 320388011365 Integrase core domain; Region: rve_3; pfam13683 320388011366 Transposase; Region: HTH_Tnp_1; pfam01527 320388011367 Transposase domain (DUF772); Region: DUF772; pfam05598 320388011368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388011369 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388011370 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 320388011371 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 320388011372 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320388011373 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 320388011374 hypothetical protein; Reviewed; Region: PRK00024 320388011375 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 320388011376 MPN+ (JAMM) motif; other site 320388011377 Zinc-binding site [ion binding]; other site 320388011378 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 320388011379 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 320388011380 L-aspartate oxidase; Provisional; Region: PRK09077 320388011381 L-aspartate oxidase; Provisional; Region: PRK06175 320388011382 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 320388011383 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 320388011384 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 320388011385 dimerization interface [polypeptide binding]; other site 320388011386 active site 320388011387 quinolinate synthetase; Provisional; Region: PRK09375 320388011388 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320388011389 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320388011390 Di-iron ligands [ion binding]; other site 320388011391 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388011392 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 320388011393 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320388011394 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 320388011395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388011396 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 320388011397 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 320388011398 active site 320388011399 substrate binding site [chemical binding]; other site 320388011400 cosubstrate binding site; other site 320388011401 catalytic site [active] 320388011402 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 320388011403 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 320388011404 active site 320388011405 Riboflavin kinase; Region: Flavokinase; smart00904 320388011406 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 320388011407 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320388011408 active site 320388011409 HIGH motif; other site 320388011410 nucleotide binding site [chemical binding]; other site 320388011411 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 320388011412 active site 320388011413 KMSKS motif; other site 320388011414 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 320388011415 tRNA binding surface [nucleotide binding]; other site 320388011416 anticodon binding site; other site 320388011417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320388011418 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 320388011419 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 320388011420 Flavoprotein; Region: Flavoprotein; pfam02441 320388011421 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 320388011422 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320388011423 trimer interface [polypeptide binding]; other site 320388011424 active site 320388011425 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 320388011426 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388011427 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388011428 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388011429 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320388011430 HTH-like domain; Region: HTH_21; pfam13276 320388011431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011432 Integrase core domain; Region: rve; pfam00665 320388011433 Integrase core domain; Region: rve_3; pfam13683 320388011434 Transposase; Region: HTH_Tnp_1; pfam01527 320388011435 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320388011436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388011437 putative substrate translocation pore; other site 320388011438 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320388011439 HAMP domain; Region: HAMP; pfam00672 320388011440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388011441 dimer interface [polypeptide binding]; other site 320388011442 phosphorylation site [posttranslational modification] 320388011443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388011444 ATP binding site [chemical binding]; other site 320388011445 Mg2+ binding site [ion binding]; other site 320388011446 G-X-G motif; other site 320388011447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388011448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388011449 active site 320388011450 phosphorylation site [posttranslational modification] 320388011451 intermolecular recognition site; other site 320388011452 dimerization interface [polypeptide binding]; other site 320388011453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388011454 DNA binding site [nucleotide binding] 320388011455 recombinase A; Provisional; Region: recA; PRK09354 320388011456 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 320388011457 hexamer interface [polypeptide binding]; other site 320388011458 Walker A motif; other site 320388011459 ATP binding site [chemical binding]; other site 320388011460 Walker B motif; other site 320388011461 recombination regulator RecX; Provisional; Region: recX; PRK14136 320388011462 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 320388011463 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 320388011464 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 320388011465 CoA-ligase; Region: Ligase_CoA; pfam00549 320388011466 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 320388011467 CoA binding domain; Region: CoA_binding; smart00881 320388011468 CoA-ligase; Region: Ligase_CoA; pfam00549 320388011469 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 320388011470 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 320388011471 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320388011472 O-Antigen ligase; Region: Wzy_C; pfam04932 320388011473 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 320388011474 hypothetical protein; Provisional; Region: PRK11667 320388011475 Gram-negative bacterial tonB protein; Region: TonB; cl10048 320388011476 HTH-like domain; Region: HTH_21; pfam13276 320388011477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011478 Integrase core domain; Region: rve; pfam00665 320388011479 Integrase core domain; Region: rve_3; pfam13683 320388011480 Transposase; Region: HTH_Tnp_1; pfam01527 320388011481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320388011482 PAS domain; Region: PAS_9; pfam13426 320388011483 putative active site [active] 320388011484 heme pocket [chemical binding]; other site 320388011485 HAMP domain; Region: HAMP; pfam00672 320388011486 dimerization interface [polypeptide binding]; other site 320388011487 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388011488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388011489 dimer interface [polypeptide binding]; other site 320388011490 putative CheW interface [polypeptide binding]; other site 320388011491 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320388011492 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 320388011493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388011494 active site 320388011495 phosphorylation site [posttranslational modification] 320388011496 intermolecular recognition site; other site 320388011497 dimerization interface [polypeptide binding]; other site 320388011498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320388011499 Zn2+ binding site [ion binding]; other site 320388011500 Mg2+ binding site [ion binding]; other site 320388011501 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 320388011502 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320388011503 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320388011504 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320388011505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388011506 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 320388011507 linker region; other site 320388011508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388011509 ATP binding site [chemical binding]; other site 320388011510 Mg2+ binding site [ion binding]; other site 320388011511 G-X-G motif; other site 320388011512 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320388011513 active site 320388011514 metal binding site [ion binding]; metal-binding site 320388011515 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 320388011516 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320388011517 galactonate dehydratase; Provisional; Region: PRK14017 320388011518 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 320388011519 putative active site pocket [active] 320388011520 putative metal binding site [ion binding]; other site 320388011521 Copper resistance protein D; Region: CopD; pfam05425 320388011522 Cytochrome c; Region: Cytochrom_C; cl11414 320388011523 Cytochrome c; Region: Cytochrom_C; cl11414 320388011524 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388011525 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320388011526 Cytochrome c; Region: Cytochrom_C; pfam00034 320388011527 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320388011528 ATP binding site [chemical binding]; other site 320388011529 Mg++ binding site [ion binding]; other site 320388011530 motif III; other site 320388011531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388011532 nucleotide binding region [chemical binding]; other site 320388011533 ATP-binding site [chemical binding]; other site 320388011534 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320388011535 dinuclear metal binding motif [ion binding]; other site 320388011536 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320388011537 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320388011538 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320388011539 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 320388011540 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320388011541 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 320388011542 glycerol kinase; Provisional; Region: glpK; PRK00047 320388011543 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 320388011544 N- and C-terminal domain interface [polypeptide binding]; other site 320388011545 active site 320388011546 MgATP binding site [chemical binding]; other site 320388011547 catalytic site [active] 320388011548 metal binding site [ion binding]; metal-binding site 320388011549 glycerol binding site [chemical binding]; other site 320388011550 homotetramer interface [polypeptide binding]; other site 320388011551 homodimer interface [polypeptide binding]; other site 320388011552 FBP binding site [chemical binding]; other site 320388011553 protein IIAGlc interface [polypeptide binding]; other site 320388011554 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 320388011555 amphipathic channel; other site 320388011556 Asn-Pro-Ala signature motifs; other site 320388011557 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 320388011558 homotrimer interaction site [polypeptide binding]; other site 320388011559 putative active site [active] 320388011560 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 320388011561 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 320388011562 putative active site [active] 320388011563 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 320388011564 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 320388011565 hinge; other site 320388011566 active site 320388011567 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 320388011568 active site 320388011569 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 320388011570 dimer interface [polypeptide binding]; other site 320388011571 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320388011572 Ligand Binding Site [chemical binding]; other site 320388011573 Molecular Tunnel; other site 320388011574 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320388011575 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320388011576 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320388011577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388011578 motif II; other site 320388011579 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 320388011580 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 320388011581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320388011582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388011583 non-specific DNA binding site [nucleotide binding]; other site 320388011584 salt bridge; other site 320388011585 sequence-specific DNA binding site [nucleotide binding]; other site 320388011586 Cupin domain; Region: Cupin_2; pfam07883 320388011587 MFS transport protein AraJ; Provisional; Region: PRK10091 320388011588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388011589 putative substrate translocation pore; other site 320388011590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388011591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388011592 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388011593 putative effector binding pocket; other site 320388011594 dimerization interface [polypeptide binding]; other site 320388011595 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 320388011596 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 320388011597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388011598 FeS/SAM binding site; other site 320388011599 TRAM domain; Region: TRAM; pfam01938 320388011600 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 320388011601 PhoH-like protein; Region: PhoH; pfam02562 320388011602 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 320388011603 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 320388011604 putative active site pocket [active] 320388011605 dimerization interface [polypeptide binding]; other site 320388011606 putative catalytic residue [active] 320388011607 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 320388011608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320388011609 Transporter associated domain; Region: CorC_HlyC; smart01091 320388011610 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 320388011611 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 320388011612 putative active site [active] 320388011613 catalytic triad [active] 320388011614 putative dimer interface [polypeptide binding]; other site 320388011615 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 320388011616 dimer interface [polypeptide binding]; other site 320388011617 motif 1; other site 320388011618 active site 320388011619 motif 2; other site 320388011620 motif 3; other site 320388011621 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 320388011622 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 320388011623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388011624 active site 320388011625 motif I; other site 320388011626 motif II; other site 320388011627 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320388011628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320388011629 putative acyl-acceptor binding pocket; other site 320388011630 Protein of unknown function DUF45; Region: DUF45; pfam01863 320388011631 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388011632 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 320388011633 dimer interface [polypeptide binding]; other site 320388011634 active site 320388011635 metal binding site [ion binding]; metal-binding site 320388011636 glutathione binding site [chemical binding]; other site 320388011637 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 320388011638 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 320388011639 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 320388011640 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 320388011641 SurA N-terminal domain; Region: SurA_N; pfam09312 320388011642 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 320388011643 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320388011644 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320388011645 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 320388011646 Organic solvent tolerance protein; Region: OstA_C; pfam04453 320388011647 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 320388011648 Phosphotransferase enzyme family; Region: APH; pfam01636 320388011649 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 320388011650 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 320388011651 Substrate binding site; other site 320388011652 metal-binding site 320388011653 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 320388011654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320388011655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388011656 Walker A/P-loop; other site 320388011657 ATP binding site [chemical binding]; other site 320388011658 Q-loop/lid; other site 320388011659 ABC transporter signature motif; other site 320388011660 Walker B; other site 320388011661 D-loop; other site 320388011662 H-loop/switch region; other site 320388011663 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 320388011664 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 320388011665 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 320388011666 enoyl-CoA hydratase; Provisional; Region: PRK06688 320388011667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388011668 substrate binding site [chemical binding]; other site 320388011669 oxyanion hole (OAH) forming residues; other site 320388011670 trimer interface [polypeptide binding]; other site 320388011671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320388011672 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 320388011673 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388011674 dimer interface [polypeptide binding]; other site 320388011675 active site 320388011676 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 320388011677 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388011678 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388011679 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 320388011680 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388011681 substrate binding site [chemical binding]; other site 320388011682 oxyanion hole (OAH) forming residues; other site 320388011683 trimer interface [polypeptide binding]; other site 320388011684 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 320388011685 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320388011686 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 320388011687 FAD binding site [chemical binding]; other site 320388011688 substrate binding site [chemical binding]; other site 320388011689 catalytic residues [active] 320388011690 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320388011691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388011692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388011693 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 320388011694 PLD-like domain; Region: PLDc_2; pfam13091 320388011695 putative active site [active] 320388011696 catalytic site [active] 320388011697 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320388011698 PLD-like domain; Region: PLDc_2; pfam13091 320388011699 putative active site [active] 320388011700 catalytic site [active] 320388011701 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 320388011702 nudix motif; other site 320388011703 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 320388011704 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 320388011705 dimer interface [polypeptide binding]; other site 320388011706 anticodon binding site; other site 320388011707 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 320388011708 homodimer interface [polypeptide binding]; other site 320388011709 motif 1; other site 320388011710 active site 320388011711 motif 2; other site 320388011712 GAD domain; Region: GAD; pfam02938 320388011713 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 320388011714 motif 3; other site 320388011715 Uncharacterized conserved protein [Function unknown]; Region: COG2928 320388011716 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 320388011717 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 320388011718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388011719 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 320388011720 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 320388011721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 320388011722 SCP-2 sterol transfer family; Region: SCP2; pfam02036 320388011723 Tim44-like domain; Region: Tim44; pfam04280 320388011724 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 320388011725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388011726 S-adenosylmethionine binding site [chemical binding]; other site 320388011727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 320388011728 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 320388011729 nucleotide binding site/active site [active] 320388011730 HIT family signature motif; other site 320388011731 catalytic residue [active] 320388011732 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 320388011733 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388011734 FAD binding domain; Region: FAD_binding_4; pfam01565 320388011735 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388011736 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 320388011737 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320388011738 Cysteine-rich domain; Region: CCG; pfam02754 320388011739 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 320388011740 threonine dehydratase; Reviewed; Region: PRK09224 320388011741 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320388011742 tetramer interface [polypeptide binding]; other site 320388011743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388011744 catalytic residue [active] 320388011745 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 320388011746 putative Ile/Val binding site [chemical binding]; other site 320388011747 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 320388011748 putative Ile/Val binding site [chemical binding]; other site 320388011749 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 320388011750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 320388011751 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 320388011752 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 320388011753 homotrimer interaction site [polypeptide binding]; other site 320388011754 putative active site [active] 320388011755 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 320388011756 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 320388011757 active site 320388011758 putative substrate binding pocket [chemical binding]; other site 320388011759 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320388011760 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320388011761 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320388011762 putative active site [active] 320388011763 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 320388011764 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 320388011765 dimer interface [polypeptide binding]; other site 320388011766 active site 320388011767 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388011768 substrate binding site [chemical binding]; other site 320388011769 catalytic residue [active] 320388011770 intracellular protease, PfpI family; Region: PfpI; TIGR01382 320388011771 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 320388011772 conserved cys residue [active] 320388011773 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320388011774 MarR family; Region: MarR; pfam01047 320388011775 MarR family; Region: MarR_2; cl17246 320388011776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388011777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320388011778 putative substrate translocation pore; other site 320388011779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388011780 EcsC protein family; Region: EcsC; pfam12787 320388011781 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320388011782 CHRD domain; Region: CHRD; pfam07452 320388011783 Transposase domain (DUF772); Region: DUF772; pfam05598 320388011784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388011785 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388011786 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 320388011787 putative active site [active] 320388011788 putative catalytic site [active] 320388011789 putative DNA binding site [nucleotide binding]; other site 320388011790 putative phosphate binding site [ion binding]; other site 320388011791 metal binding site A [ion binding]; metal-binding site 320388011792 putative AP binding site [nucleotide binding]; other site 320388011793 putative metal binding site B [ion binding]; other site 320388011794 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 320388011795 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 320388011796 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 320388011797 GatB domain; Region: GatB_Yqey; smart00845 320388011798 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 320388011799 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 320388011800 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 320388011801 rod shape-determining protein MreB; Provisional; Region: PRK13927 320388011802 MreB and similar proteins; Region: MreB_like; cd10225 320388011803 nucleotide binding site [chemical binding]; other site 320388011804 Mg binding site [ion binding]; other site 320388011805 putative protofilament interaction site [polypeptide binding]; other site 320388011806 RodZ interaction site [polypeptide binding]; other site 320388011807 rod shape-determining protein MreC; Provisional; Region: PRK13922 320388011808 rod shape-determining protein MreC; Region: MreC; pfam04085 320388011809 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 320388011810 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 320388011811 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320388011812 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320388011813 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 320388011814 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 320388011815 Sel1 repeat; Region: Sel1; cl02723 320388011816 Sel1-like repeats; Region: SEL1; smart00671 320388011817 Sel1-like repeats; Region: SEL1; smart00671 320388011818 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 320388011819 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 320388011820 active site 320388011821 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 320388011822 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 320388011823 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 320388011824 Ligand Binding Site [chemical binding]; other site 320388011825 Response regulator receiver domain; Region: Response_reg; pfam00072 320388011826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388011827 active site 320388011828 phosphorylation site [posttranslational modification] 320388011829 intermolecular recognition site; other site 320388011830 dimerization interface [polypeptide binding]; other site 320388011831 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320388011832 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388011833 dimerization interface [polypeptide binding]; other site 320388011834 PAS domain; Region: PAS; smart00091 320388011835 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 320388011836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388011837 dimer interface [polypeptide binding]; other site 320388011838 phosphorylation site [posttranslational modification] 320388011839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388011840 ATP binding site [chemical binding]; other site 320388011841 Mg2+ binding site [ion binding]; other site 320388011842 G-X-G motif; other site 320388011843 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 320388011844 16S rRNA methyltransferase B; Provisional; Region: PRK10901 320388011845 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 320388011846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388011847 S-adenosylmethionine binding site [chemical binding]; other site 320388011848 M48 family peptidase; Provisional; Region: PRK03001 320388011849 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388011850 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 320388011851 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 320388011852 putative active site [active] 320388011853 substrate binding site [chemical binding]; other site 320388011854 putative cosubstrate binding site; other site 320388011855 catalytic site [active] 320388011856 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 320388011857 substrate binding site [chemical binding]; other site 320388011858 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320388011859 active site 320388011860 catalytic residues [active] 320388011861 metal binding site [ion binding]; metal-binding site 320388011862 DNA protecting protein DprA; Region: dprA; TIGR00732 320388011863 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 320388011864 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320388011865 catalytic residues [active] 320388011866 DNA topoisomerase III; Validated; Region: PRK08173 320388011867 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 320388011868 active site 320388011869 putative interdomain interaction site [polypeptide binding]; other site 320388011870 putative metal-binding site [ion binding]; other site 320388011871 putative nucleotide binding site [chemical binding]; other site 320388011872 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 320388011873 domain I; other site 320388011874 DNA binding groove [nucleotide binding] 320388011875 phosphate binding site [ion binding]; other site 320388011876 domain II; other site 320388011877 domain III; other site 320388011878 nucleotide binding site [chemical binding]; other site 320388011879 catalytic site [active] 320388011880 domain IV; other site 320388011881 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 320388011882 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 320388011883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388011884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388011885 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388011886 putative effector binding pocket; other site 320388011887 dimerization interface [polypeptide binding]; other site 320388011888 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 320388011889 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 320388011890 dimerization interface [polypeptide binding]; other site 320388011891 NAD binding site [chemical binding]; other site 320388011892 ligand binding site [chemical binding]; other site 320388011893 catalytic site [active] 320388011894 Patatin-like phospholipase; Region: Patatin; pfam01734 320388011895 active site 320388011896 nucleophile elbow; other site 320388011897 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 320388011898 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320388011899 CoenzymeA binding site [chemical binding]; other site 320388011900 subunit interaction site [polypeptide binding]; other site 320388011901 PHB binding site; other site 320388011902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388011903 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388011904 Transposase; Region: HTH_Tnp_1; pfam01527 320388011905 HTH-like domain; Region: HTH_21; pfam13276 320388011906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011907 Integrase core domain; Region: rve; pfam00665 320388011908 Integrase core domain; Region: rve_3; pfam13683 320388011909 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 320388011910 portal vertex protein; Provisional; Region: Q; PHA02536 320388011911 Phage portal protein; Region: Phage_portal; pfam04860 320388011912 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 320388011913 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 320388011914 putative active site; other site 320388011915 catalytic triad [active] 320388011916 putative dimer interface [polypeptide binding]; other site 320388011917 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320388011918 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 320388011919 active site 320388011920 Zn binding site [ion binding]; other site 320388011921 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 320388011922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320388011923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388011924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388011925 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320388011926 putative effector binding pocket; other site 320388011927 dimerization interface [polypeptide binding]; other site 320388011928 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 320388011929 dimer interface [polypeptide binding]; other site 320388011930 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 320388011931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388011932 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320388011933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388011934 DNA binding residues [nucleotide binding] 320388011935 glutamate--cysteine ligase; Provisional; Region: PRK02107 320388011936 AlkA N-terminal domain; Region: AlkA_N; pfam06029 320388011937 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 320388011938 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320388011939 minor groove reading motif; other site 320388011940 helix-hairpin-helix signature motif; other site 320388011941 substrate binding pocket [chemical binding]; other site 320388011942 active site 320388011943 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 320388011944 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 320388011945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388011946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388011947 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 320388011948 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 320388011949 DNA binding site [nucleotide binding] 320388011950 active site 320388011951 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 320388011952 dimer interface [polypeptide binding]; other site 320388011953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320388011954 metal binding site [ion binding]; metal-binding site 320388011955 YaeQ protein; Region: YaeQ; pfam07152 320388011956 Transposase; Region: HTH_Tnp_1; pfam01527 320388011957 HTH-like domain; Region: HTH_21; pfam13276 320388011958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388011959 Integrase core domain; Region: rve; pfam00665 320388011960 Integrase core domain; Region: rve_3; pfam13683 320388011961 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 320388011962 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 320388011963 trmE is a tRNA modification GTPase; Region: trmE; cd04164 320388011964 G1 box; other site 320388011965 GTP/Mg2+ binding site [chemical binding]; other site 320388011966 Switch I region; other site 320388011967 G2 box; other site 320388011968 Switch II region; other site 320388011969 G3 box; other site 320388011970 G4 box; other site 320388011971 G5 box; other site 320388011972 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 320388011973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320388011974 sequence-specific DNA binding site [nucleotide binding]; other site 320388011975 salt bridge; other site 320388011976 membrane protein insertase; Provisional; Region: PRK01318 320388011977 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 320388011978 hypothetical protein; Validated; Region: PRK00041 320388011979 Ribonuclease P; Region: Ribonuclease_P; cl00457 320388011980 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 320388011981 DnaA N-terminal domain; Region: DnaA_N; pfam11638 320388011982 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 320388011983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388011984 Walker A motif; other site 320388011985 ATP binding site [chemical binding]; other site 320388011986 Walker B motif; other site 320388011987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320388011988 arginine finger; other site 320388011989 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 320388011990 DnaA box-binding interface [nucleotide binding]; other site 320388011991 DNA polymerase III subunit beta; Validated; Region: PRK05643 320388011992 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 320388011993 putative DNA binding surface [nucleotide binding]; other site 320388011994 dimer interface [polypeptide binding]; other site 320388011995 beta-clamp/clamp loader binding surface; other site 320388011996 beta-clamp/translesion DNA polymerase binding surface; other site 320388011997 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 320388011998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388011999 ATP binding site [chemical binding]; other site 320388012000 Mg2+ binding site [ion binding]; other site 320388012001 G-X-G motif; other site 320388012002 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 320388012003 anchoring element; other site 320388012004 dimer interface [polypeptide binding]; other site 320388012005 ATP binding site [chemical binding]; other site 320388012006 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 320388012007 active site 320388012008 putative metal-binding site [ion binding]; other site 320388012009 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 320388012010 Transposase; Region: HTH_Tnp_1; pfam01527 320388012011 HTH-like domain; Region: HTH_21; pfam13276 320388012012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012013 Integrase core domain; Region: rve; pfam00665 320388012014 Integrase core domain; Region: rve_3; pfam13683 320388012015 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 320388012016 Family description; Region: VCBS; pfam13517 320388012017 Family description; Region: VCBS; pfam13517 320388012018 Family description; Region: VCBS; pfam13517 320388012019 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 320388012020 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 320388012021 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320388012022 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320388012023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 320388012024 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 320388012025 phosphopeptide binding site; other site 320388012026 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 320388012027 active site 320388012028 ATP binding site [chemical binding]; other site 320388012029 substrate binding site [chemical binding]; other site 320388012030 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 320388012031 activation loop (A-loop); other site 320388012032 cyclase homology domain; Region: CHD; cd07302 320388012033 dimer interface [polypeptide binding]; other site 320388012034 nucleotidyl binding site; other site 320388012035 metal binding site [ion binding]; metal-binding site 320388012036 AAA ATPase domain; Region: AAA_16; pfam13191 320388012037 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 320388012038 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 320388012039 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 320388012040 YcaO-like family; Region: YcaO; pfam02624 320388012041 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 320388012042 aldolase II superfamily protein; Provisional; Region: PRK07044 320388012043 intersubunit interface [polypeptide binding]; other site 320388012044 active site 320388012045 Zn2+ binding site [ion binding]; other site 320388012046 PAS domain; Region: PAS; smart00091 320388012047 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320388012048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320388012049 metal binding site [ion binding]; metal-binding site 320388012050 active site 320388012051 I-site; other site 320388012052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320388012053 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 320388012054 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320388012055 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388012056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388012057 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 320388012058 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320388012059 Substrate binding site; other site 320388012060 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 320388012061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320388012062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388012063 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 320388012064 putative ADP-binding pocket [chemical binding]; other site 320388012065 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 320388012066 active site 320388012067 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320388012068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388012069 Walker A motif; other site 320388012070 ATP binding site [chemical binding]; other site 320388012071 Walker B motif; other site 320388012072 arginine finger; other site 320388012073 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 320388012074 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 320388012075 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 320388012076 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 320388012077 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 320388012078 dimer interface [polypeptide binding]; other site 320388012079 motif 1; other site 320388012080 active site 320388012081 motif 2; other site 320388012082 motif 3; other site 320388012083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388012084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388012085 active site 320388012086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388012087 active site 320388012088 acyl carrier protein; Provisional; Region: PRK07081 320388012089 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320388012090 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320388012091 ligand binding site [chemical binding]; other site 320388012092 flexible hinge region; other site 320388012093 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320388012094 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320388012095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 320388012096 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320388012097 non-specific DNA interactions [nucleotide binding]; other site 320388012098 DNA binding site [nucleotide binding] 320388012099 sequence specific DNA binding site [nucleotide binding]; other site 320388012100 putative cAMP binding site [chemical binding]; other site 320388012101 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 320388012102 Bacterial sugar transferase; Region: Bac_transf; pfam02397 320388012103 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320388012104 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 320388012105 SLBB domain; Region: SLBB; pfam10531 320388012106 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320388012107 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 320388012108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388012109 Transposase domain (DUF772); Region: DUF772; pfam05598 320388012110 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388012111 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320388012112 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 320388012113 putative NAD(P) binding site [chemical binding]; other site 320388012114 putative substrate binding site [chemical binding]; other site 320388012115 catalytic Zn binding site [ion binding]; other site 320388012116 structural Zn binding site [ion binding]; other site 320388012117 dimer interface [polypeptide binding]; other site 320388012118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388012119 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388012120 HTH-like domain; Region: HTH_21; pfam13276 320388012121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012122 Integrase core domain; Region: rve; pfam00665 320388012123 Integrase core domain; Region: rve_3; pfam13683 320388012124 Transposase; Region: HTH_Tnp_1; pfam01527 320388012125 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 320388012126 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388012127 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 320388012128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388012129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388012130 Peptidase family M48; Region: Peptidase_M48; cl12018 320388012131 muropeptide transporter; Reviewed; Region: ampG; PRK11902 320388012132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388012133 putative substrate translocation pore; other site 320388012134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320388012135 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 320388012136 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 320388012137 division inhibitor protein; Provisional; Region: slmA; PRK09480 320388012138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388012139 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 320388012140 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 320388012141 feedback inhibition sensing region; other site 320388012142 homohexameric interface [polypeptide binding]; other site 320388012143 nucleotide binding site [chemical binding]; other site 320388012144 N-acetyl-L-glutamate binding site [chemical binding]; other site 320388012145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388012146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 320388012147 dimer interface [polypeptide binding]; other site 320388012148 phosphorylation site [posttranslational modification] 320388012149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388012150 ATP binding site [chemical binding]; other site 320388012151 Mg2+ binding site [ion binding]; other site 320388012152 G-X-G motif; other site 320388012153 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 320388012154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388012155 active site 320388012156 phosphorylation site [posttranslational modification] 320388012157 intermolecular recognition site; other site 320388012158 dimerization interface [polypeptide binding]; other site 320388012159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320388012160 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 320388012161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388012162 Walker A motif; other site 320388012163 ATP binding site [chemical binding]; other site 320388012164 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 320388012165 Walker B motif; other site 320388012166 arginine finger; other site 320388012167 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320388012168 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 320388012169 active site 320388012170 HslU subunit interaction site [polypeptide binding]; other site 320388012171 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 320388012172 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 320388012173 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 320388012174 P-loop, Walker A motif; other site 320388012175 Base recognition motif; other site 320388012176 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 320388012177 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 320388012178 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 320388012179 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 320388012180 putative RNA binding site [nucleotide binding]; other site 320388012181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388012182 S-adenosylmethionine binding site [chemical binding]; other site 320388012183 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 320388012184 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320388012185 active site 320388012186 DNA binding site [nucleotide binding] 320388012187 Int/Topo IB signature motif; other site 320388012188 Protein of unknown function, DUF484; Region: DUF484; cl17449 320388012189 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 320388012190 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320388012191 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320388012192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 320388012193 putative acyl-acceptor binding pocket; other site 320388012194 S-adenosylmethionine synthetase; Validated; Region: PRK05250 320388012195 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 320388012196 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 320388012197 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 320388012198 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 320388012199 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 320388012200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320388012201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320388012202 active site 320388012203 catalytic tetrad [active] 320388012204 EamA-like transporter family; Region: EamA; pfam00892 320388012205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388012206 putative substrate translocation pore; other site 320388012207 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320388012208 serine/threonine protein kinase; Provisional; Region: PRK11768 320388012209 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 320388012210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320388012211 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 320388012212 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 320388012213 NAD(P) binding site [chemical binding]; other site 320388012214 catalytic residues [active] 320388012215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388012216 active site 320388012217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388012218 choline dehydrogenase; Validated; Region: PRK02106 320388012219 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388012220 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 320388012221 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 320388012222 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 320388012223 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 320388012224 Walker A motif/ATP binding site; other site 320388012225 Walker B motif; other site 320388012226 flagellar assembly protein H; Validated; Region: fliH; PRK05687 320388012227 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 320388012228 Flagellar assembly protein FliH; Region: FliH; pfam02108 320388012229 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 320388012230 FliG C-terminal domain; Region: FliG_C; pfam01706 320388012231 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 320388012232 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 320388012233 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 320388012234 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 320388012235 flagellar protein FliS; Validated; Region: fliS; PRK05685 320388012236 Flagellar protein FliT; Region: FliT; cl05125 320388012237 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 320388012238 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 320388012239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 320388012240 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 320388012241 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 320388012242 XdhC Rossmann domain; Region: XdhC_C; pfam13478 320388012243 amino acid transporter; Region: 2A0306; TIGR00909 320388012244 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 320388012245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320388012246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388012247 active site 320388012248 phosphorylation site [posttranslational modification] 320388012249 intermolecular recognition site; other site 320388012250 dimerization interface [polypeptide binding]; other site 320388012251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320388012252 DNA binding residues [nucleotide binding] 320388012253 dimerization interface [polypeptide binding]; other site 320388012254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 320388012255 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320388012256 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 320388012257 FAD binding pocket [chemical binding]; other site 320388012258 FAD binding motif [chemical binding]; other site 320388012259 phosphate binding motif [ion binding]; other site 320388012260 beta-alpha-beta structure motif; other site 320388012261 NAD binding pocket [chemical binding]; other site 320388012262 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388012263 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 320388012264 putative catalytic site [active] 320388012265 putative phosphate binding site [ion binding]; other site 320388012266 putative metal binding site [ion binding]; other site 320388012267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320388012268 Walker A motif; other site 320388012269 ATP binding site [chemical binding]; other site 320388012270 Walker B motif; other site 320388012271 arginine finger; other site 320388012272 Predicted dehydrogenase [General function prediction only]; Region: COG0579 320388012273 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320388012274 High potential iron-sulfur protein; Region: HIPIP; pfam01355 320388012275 citrate-proton symporter; Provisional; Region: PRK15075 320388012276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388012277 putative substrate translocation pore; other site 320388012278 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320388012279 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 320388012280 peptide binding site [polypeptide binding]; other site 320388012281 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 320388012282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388012283 dimer interface [polypeptide binding]; other site 320388012284 conserved gate region; other site 320388012285 putative PBP binding loops; other site 320388012286 ABC-ATPase subunit interface; other site 320388012287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388012288 dimer interface [polypeptide binding]; other site 320388012289 conserved gate region; other site 320388012290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 320388012291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388012292 Walker A/P-loop; other site 320388012293 ATP binding site [chemical binding]; other site 320388012294 Q-loop/lid; other site 320388012295 ABC transporter signature motif; other site 320388012296 Walker B; other site 320388012297 D-loop; other site 320388012298 H-loop/switch region; other site 320388012299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320388012300 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 320388012301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320388012302 Walker A/P-loop; other site 320388012303 ATP binding site [chemical binding]; other site 320388012304 Q-loop/lid; other site 320388012305 ABC transporter signature motif; other site 320388012306 Walker B; other site 320388012307 D-loop; other site 320388012308 H-loop/switch region; other site 320388012309 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 320388012310 TraB family; Region: TraB; pfam01963 320388012311 Transposase domain (DUF772); Region: DUF772; pfam05598 320388012312 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388012313 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388012314 Predicted membrane protein [Function unknown]; Region: COG3817 320388012315 Protein of unknown function (DUF979); Region: DUF979; pfam06166 320388012316 Protein of unknown function (DUF969); Region: DUF969; pfam06149 320388012317 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 320388012318 putative active site [active] 320388012319 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 320388012320 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 320388012321 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 320388012322 MarR family; Region: MarR_2; cl17246 320388012323 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 320388012324 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 320388012325 lytic murein transglycosylase; Provisional; Region: PRK11619 320388012326 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320388012327 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320388012328 catalytic residue [active] 320388012329 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 320388012330 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 320388012331 putative NAD(P) binding site [chemical binding]; other site 320388012332 active site 320388012333 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320388012334 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 320388012335 putative C-terminal domain interface [polypeptide binding]; other site 320388012336 putative GSH binding site (G-site) [chemical binding]; other site 320388012337 putative dimer interface [polypeptide binding]; other site 320388012338 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 320388012339 putative N-terminal domain interface [polypeptide binding]; other site 320388012340 putative dimer interface [polypeptide binding]; other site 320388012341 putative substrate binding pocket (H-site) [chemical binding]; other site 320388012342 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 320388012343 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 320388012344 active site 320388012345 NTP binding site [chemical binding]; other site 320388012346 metal binding triad [ion binding]; metal-binding site 320388012347 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 320388012348 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 320388012349 Killing trait; Region: RebB; pfam11747 320388012350 FlgN protein; Region: FlgN; pfam05130 320388012351 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 320388012352 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 320388012353 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 320388012354 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 320388012355 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 320388012356 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 320388012357 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320388012358 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320388012359 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 320388012360 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 320388012361 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 320388012362 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 320388012363 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320388012364 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 320388012365 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320388012366 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 320388012367 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320388012368 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 320388012369 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 320388012370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320388012371 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320388012372 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 320388012373 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 320388012374 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 320388012375 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 320388012376 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 320388012377 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 320388012378 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 320388012379 Flagellar regulator YcgR; Region: YcgR; pfam07317 320388012380 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 320388012381 PilZ domain; Region: PilZ; pfam07238 320388012382 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 320388012383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320388012384 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 320388012385 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320388012386 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 320388012387 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320388012388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388012389 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320388012390 dimerization interface [polypeptide binding]; other site 320388012391 substrate binding pocket [chemical binding]; other site 320388012392 Chromate transporter; Region: Chromate_transp; pfam02417 320388012393 Chromate transporter; Region: Chromate_transp; pfam02417 320388012394 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 320388012395 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 320388012396 PhnA protein; Region: PhnA; pfam03831 320388012397 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 320388012398 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388012399 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388012400 trimer interface [polypeptide binding]; other site 320388012401 eyelet of channel; other site 320388012402 putative membrane protein; Region: HpnL; TIGR03476 320388012403 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 320388012404 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 320388012405 ligand binding site; other site 320388012406 HTH-like domain; Region: HTH_21; pfam13276 320388012407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012408 Integrase core domain; Region: rve; pfam00665 320388012409 Integrase core domain; Region: rve_3; pfam13683 320388012410 Transposase; Region: HTH_Tnp_1; pfam01527 320388012411 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 320388012412 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 320388012413 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320388012414 Transposase domain (DUF772); Region: DUF772; pfam05598 320388012415 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388012416 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388012417 glutathione reductase; Validated; Region: PRK06116 320388012418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388012419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388012420 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320388012421 argininosuccinate synthase; Validated; Region: PRK05370 320388012422 argininosuccinate synthase; Provisional; Region: PRK13820 320388012423 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 320388012424 metal-binding site [ion binding] 320388012425 YHS domain; Region: YHS; pfam04945 320388012426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 320388012427 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320388012428 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320388012429 LemA family; Region: LemA; pfam04011 320388012430 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 320388012431 Repair protein; Region: Repair_PSII; pfam04536 320388012432 Repair protein; Region: Repair_PSII; pfam04536 320388012433 HlyD family secretion protein; Region: HlyD_2; pfam12700 320388012434 HlyD family secretion protein; Region: HlyD_3; pfam13437 320388012435 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 320388012436 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 320388012437 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 320388012438 Avidin family; Region: Avidin; pfam01382 320388012439 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320388012440 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320388012441 glutaminase active site [active] 320388012442 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320388012443 dimer interface [polypeptide binding]; other site 320388012444 active site 320388012445 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320388012446 dimer interface [polypeptide binding]; other site 320388012447 active site 320388012448 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 320388012449 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 320388012450 Substrate binding site; other site 320388012451 Mg++ binding site; other site 320388012452 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 320388012453 active site 320388012454 substrate binding site [chemical binding]; other site 320388012455 CoA binding site [chemical binding]; other site 320388012456 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 320388012457 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 320388012458 Ligand Binding Site [chemical binding]; other site 320388012459 Dihydroneopterin aldolase; Region: FolB; smart00905 320388012460 active site 320388012461 short chain dehydrogenase; Provisional; Region: PRK09134 320388012462 Uncharacterized conserved protein [Function unknown]; Region: COG1565 320388012463 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 320388012464 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 320388012465 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320388012466 putative substrate binding site [chemical binding]; other site 320388012467 putative ATP binding site [chemical binding]; other site 320388012468 dimerization interface [polypeptide binding]; other site 320388012469 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 320388012470 putative active cleft [active] 320388012471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320388012472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320388012473 DNA binding site [nucleotide binding] 320388012474 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 320388012475 ligand binding site [chemical binding]; other site 320388012476 dimerization interface [polypeptide binding]; other site 320388012477 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320388012478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388012479 dimer interface [polypeptide binding]; other site 320388012480 putative CheW interface [polypeptide binding]; other site 320388012481 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 320388012482 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 320388012483 Transposase; Region: HTH_Tnp_1; pfam01527 320388012484 HTH-like domain; Region: HTH_21; pfam13276 320388012485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012486 Integrase core domain; Region: rve; pfam00665 320388012487 Integrase core domain; Region: rve_3; pfam13683 320388012488 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 320388012489 dimer interface [polypeptide binding]; other site 320388012490 Alkaline phosphatase homologues; Region: alkPPc; smart00098 320388012491 active site 320388012492 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 320388012493 Alkaline phosphatase homologues; Region: alkPPc; smart00098 320388012494 active site 320388012495 dimer interface [polypeptide binding]; other site 320388012496 CutC family; Region: CutC; cl01218 320388012497 biotin synthase; Region: bioB; TIGR00433 320388012498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320388012499 FeS/SAM binding site; other site 320388012500 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 320388012501 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 320388012502 AAA domain; Region: AAA_26; pfam13500 320388012503 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 320388012504 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320388012505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320388012506 catalytic residue [active] 320388012507 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 320388012508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320388012509 inhibitor-cofactor binding pocket; inhibition site 320388012510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388012511 catalytic residue [active] 320388012512 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 320388012513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320388012514 hypothetical protein; Provisional; Region: PRK01842 320388012515 short chain dehydrogenase; Provisional; Region: PRK06953 320388012516 NAD(P) binding site [chemical binding]; other site 320388012517 active site 320388012518 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 320388012519 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388012520 dimer interface [polypeptide binding]; other site 320388012521 active site 320388012522 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 320388012523 active site clefts [active] 320388012524 zinc binding site [ion binding]; other site 320388012525 dimer interface [polypeptide binding]; other site 320388012526 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 320388012527 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 320388012528 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320388012529 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 320388012530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320388012531 Walker A/P-loop; other site 320388012532 ATP binding site [chemical binding]; other site 320388012533 Q-loop/lid; other site 320388012534 ABC transporter signature motif; other site 320388012535 Walker B; other site 320388012536 D-loop; other site 320388012537 H-loop/switch region; other site 320388012538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320388012539 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320388012540 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 320388012541 peptide binding site [polypeptide binding]; other site 320388012542 MarR family; Region: MarR_2; cl17246 320388012543 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320388012544 short chain dehydrogenase; Validated; Region: PRK08264 320388012545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388012546 NAD(P) binding site [chemical binding]; other site 320388012547 active site 320388012548 short chain dehydrogenase; Provisional; Region: PRK07024 320388012549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320388012550 NAD(P) binding site [chemical binding]; other site 320388012551 active site 320388012552 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 320388012553 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 320388012554 catalytic residues [active] 320388012555 hinge region; other site 320388012556 alpha helical domain; other site 320388012557 Sporulation related domain; Region: SPOR; pfam05036 320388012558 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 320388012559 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 320388012560 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 320388012561 active site 320388012562 HIGH motif; other site 320388012563 KMSK motif region; other site 320388012564 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320388012565 tRNA binding surface [nucleotide binding]; other site 320388012566 anticodon binding site; other site 320388012567 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 320388012568 Transposase domain (DUF772); Region: DUF772; pfam05598 320388012569 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388012570 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388012571 HTH-like domain; Region: HTH_21; pfam13276 320388012572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012573 Integrase core domain; Region: rve; pfam00665 320388012574 Integrase core domain; Region: rve_3; pfam13683 320388012575 Transposase; Region: HTH_Tnp_1; pfam01527 320388012576 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 320388012577 active site 320388012578 catalytic triad [active] 320388012579 oxyanion hole [active] 320388012580 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 320388012581 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 320388012582 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 320388012583 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 320388012584 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 320388012585 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 320388012586 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 320388012587 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 320388012588 FAD binding pocket [chemical binding]; other site 320388012589 FAD binding motif [chemical binding]; other site 320388012590 phosphate binding motif [ion binding]; other site 320388012591 beta-alpha-beta structure motif; other site 320388012592 NAD(p) ribose binding residues [chemical binding]; other site 320388012593 NAD binding pocket [chemical binding]; other site 320388012594 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 320388012595 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320388012596 catalytic loop [active] 320388012597 iron binding site [ion binding]; other site 320388012598 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 320388012599 Protein of unknown function; Region: DUF3658; pfam12395 320388012600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388012601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388012602 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320388012603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320388012604 Coenzyme A binding pocket [chemical binding]; other site 320388012605 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388012606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388012607 putative DNA binding site [nucleotide binding]; other site 320388012608 putative Zn2+ binding site [ion binding]; other site 320388012609 AsnC family; Region: AsnC_trans_reg; pfam01037 320388012610 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 320388012611 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 320388012612 dimer interface [polypeptide binding]; other site 320388012613 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 320388012614 active site 320388012615 Fe binding site [ion binding]; other site 320388012616 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 320388012617 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 320388012618 dimer interface [polypeptide binding]; other site 320388012619 PYR/PP interface [polypeptide binding]; other site 320388012620 TPP binding site [chemical binding]; other site 320388012621 substrate binding site [chemical binding]; other site 320388012622 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 320388012623 TPP-binding site; other site 320388012624 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 320388012625 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 320388012626 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320388012627 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320388012628 putative NAD(P) binding site [chemical binding]; other site 320388012629 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 320388012630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388012631 active site 320388012632 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 320388012633 substrate binding site [chemical binding]; other site 320388012634 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 320388012635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388012636 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 320388012637 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320388012638 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388012639 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388012640 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320388012641 HTH-like domain; Region: HTH_21; pfam13276 320388012642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012643 Integrase core domain; Region: rve; pfam00665 320388012644 Integrase core domain; Region: rve_3; pfam13683 320388012645 Transposase; Region: HTH_Tnp_1; pfam01527 320388012646 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 320388012647 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 320388012648 ResB-like family; Region: ResB; pfam05140 320388012649 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 320388012650 ResB-like family; Region: ResB; pfam05140 320388012651 Cytochrome c553 [Energy production and conversion]; Region: COG2863 320388012652 Cytochrome c; Region: Cytochrom_C; cl11414 320388012653 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 320388012654 G1 box; other site 320388012655 GTP/Mg2+ binding site [chemical binding]; other site 320388012656 Switch I region; other site 320388012657 G2 box; other site 320388012658 G3 box; other site 320388012659 Switch II region; other site 320388012660 G4 box; other site 320388012661 G5 box; other site 320388012662 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 320388012663 dimer interface [polypeptide binding]; other site 320388012664 active site 320388012665 aspartate-rich active site metal binding site; other site 320388012666 allosteric magnesium binding site [ion binding]; other site 320388012667 Schiff base residues; other site 320388012668 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 320388012669 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 320388012670 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 320388012671 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 320388012672 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320388012673 DsbD alpha interface [polypeptide binding]; other site 320388012674 catalytic residues [active] 320388012675 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 320388012676 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 320388012677 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 320388012678 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 320388012679 alphaNTD homodimer interface [polypeptide binding]; other site 320388012680 alphaNTD - beta interaction site [polypeptide binding]; other site 320388012681 alphaNTD - beta' interaction site [polypeptide binding]; other site 320388012682 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 320388012683 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 320388012684 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 320388012685 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320388012686 RNA binding surface [nucleotide binding]; other site 320388012687 30S ribosomal protein S11; Validated; Region: PRK05309 320388012688 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 320388012689 30S ribosomal protein S13; Region: bact_S13; TIGR03631 320388012690 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 320388012691 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 320388012692 rRNA binding site [nucleotide binding]; other site 320388012693 predicted 30S ribosome binding site; other site 320388012694 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 320388012695 SecY translocase; Region: SecY; pfam00344 320388012696 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 320388012697 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 320388012698 23S rRNA binding site [nucleotide binding]; other site 320388012699 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 320388012700 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 320388012701 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 320388012702 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 320388012703 5S rRNA interface [nucleotide binding]; other site 320388012704 L27 interface [polypeptide binding]; other site 320388012705 23S rRNA interface [nucleotide binding]; other site 320388012706 L5 interface [polypeptide binding]; other site 320388012707 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 320388012708 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320388012709 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320388012710 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 320388012711 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 320388012712 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 320388012713 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 320388012714 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 320388012715 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 320388012716 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 320388012717 RNA binding site [nucleotide binding]; other site 320388012718 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 320388012719 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 320388012720 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 320388012721 23S rRNA interface [nucleotide binding]; other site 320388012722 putative translocon interaction site; other site 320388012723 signal recognition particle (SRP54) interaction site; other site 320388012724 L23 interface [polypeptide binding]; other site 320388012725 trigger factor interaction site; other site 320388012726 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 320388012727 23S rRNA interface [nucleotide binding]; other site 320388012728 5S rRNA interface [nucleotide binding]; other site 320388012729 putative antibiotic binding site [chemical binding]; other site 320388012730 L25 interface [polypeptide binding]; other site 320388012731 L27 interface [polypeptide binding]; other site 320388012732 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 320388012733 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 320388012734 G-X-X-G motif; other site 320388012735 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 320388012736 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 320388012737 putative translocon binding site; other site 320388012738 protein-rRNA interface [nucleotide binding]; other site 320388012739 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 320388012740 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 320388012741 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 320388012742 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 320388012743 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 320388012744 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 320388012745 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 320388012746 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 320388012747 elongation factor Tu; Reviewed; Region: PRK00049 320388012748 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320388012749 G1 box; other site 320388012750 GEF interaction site [polypeptide binding]; other site 320388012751 GTP/Mg2+ binding site [chemical binding]; other site 320388012752 Switch I region; other site 320388012753 G2 box; other site 320388012754 G3 box; other site 320388012755 Switch II region; other site 320388012756 G4 box; other site 320388012757 G5 box; other site 320388012758 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320388012759 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320388012760 Antibiotic Binding Site [chemical binding]; other site 320388012761 elongation factor G; Reviewed; Region: PRK00007 320388012762 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 320388012763 G1 box; other site 320388012764 putative GEF interaction site [polypeptide binding]; other site 320388012765 GTP/Mg2+ binding site [chemical binding]; other site 320388012766 Switch I region; other site 320388012767 G2 box; other site 320388012768 G3 box; other site 320388012769 Switch II region; other site 320388012770 G4 box; other site 320388012771 G5 box; other site 320388012772 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 320388012773 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 320388012774 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 320388012775 30S ribosomal protein S7; Validated; Region: PRK05302 320388012776 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 320388012777 S17 interaction site [polypeptide binding]; other site 320388012778 S8 interaction site; other site 320388012779 16S rRNA interaction site [nucleotide binding]; other site 320388012780 streptomycin interaction site [chemical binding]; other site 320388012781 23S rRNA interaction site [nucleotide binding]; other site 320388012782 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 320388012783 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 320388012784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388012785 ATP binding site [chemical binding]; other site 320388012786 putative Mg++ binding site [ion binding]; other site 320388012787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320388012788 nucleotide binding region [chemical binding]; other site 320388012789 ATP-binding site [chemical binding]; other site 320388012790 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 320388012791 HRDC domain; Region: HRDC; pfam00570 320388012792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388012793 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388012794 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 320388012795 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 320388012796 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 320388012797 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 320388012798 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 320388012799 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 320388012800 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 320388012801 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 320388012802 DNA binding site [nucleotide binding] 320388012803 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 320388012804 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 320388012805 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 320388012806 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 320388012807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320388012808 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 320388012809 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320388012810 RPB3 interaction site [polypeptide binding]; other site 320388012811 RPB1 interaction site [polypeptide binding]; other site 320388012812 RPB11 interaction site [polypeptide binding]; other site 320388012813 RPB10 interaction site [polypeptide binding]; other site 320388012814 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 320388012815 peripheral dimer interface [polypeptide binding]; other site 320388012816 core dimer interface [polypeptide binding]; other site 320388012817 L10 interface [polypeptide binding]; other site 320388012818 L11 interface [polypeptide binding]; other site 320388012819 putative EF-Tu interaction site [polypeptide binding]; other site 320388012820 putative EF-G interaction site [polypeptide binding]; other site 320388012821 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 320388012822 23S rRNA interface [nucleotide binding]; other site 320388012823 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 320388012824 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 320388012825 mRNA/rRNA interface [nucleotide binding]; other site 320388012826 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 320388012827 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 320388012828 23S rRNA interface [nucleotide binding]; other site 320388012829 L7/L12 interface [polypeptide binding]; other site 320388012830 putative thiostrepton binding site; other site 320388012831 L25 interface [polypeptide binding]; other site 320388012832 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 320388012833 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 320388012834 putative homodimer interface [polypeptide binding]; other site 320388012835 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 320388012836 heterodimer interface [polypeptide binding]; other site 320388012837 homodimer interface [polypeptide binding]; other site 320388012838 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 320388012839 elongation factor Tu; Reviewed; Region: PRK00049 320388012840 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320388012841 G1 box; other site 320388012842 GEF interaction site [polypeptide binding]; other site 320388012843 GTP/Mg2+ binding site [chemical binding]; other site 320388012844 Switch I region; other site 320388012845 G2 box; other site 320388012846 G3 box; other site 320388012847 Switch II region; other site 320388012848 G4 box; other site 320388012849 G5 box; other site 320388012850 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320388012851 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320388012852 Antibiotic Binding Site [chemical binding]; other site 320388012853 Transposase; Region: HTH_Tnp_1; pfam01527 320388012854 HTH-like domain; Region: HTH_21; pfam13276 320388012855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388012856 Integrase core domain; Region: rve; pfam00665 320388012857 Integrase core domain; Region: rve_3; pfam13683 320388012858 TMAO/DMSO reductase; Reviewed; Region: PRK05363 320388012859 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 320388012860 Moco binding site; other site 320388012861 metal coordination site [ion binding]; other site 320388012862 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 320388012863 diaminopimelate decarboxylase; Region: lysA; TIGR01048 320388012864 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 320388012865 active site 320388012866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320388012867 substrate binding site [chemical binding]; other site 320388012868 catalytic residues [active] 320388012869 dimer interface [polypeptide binding]; other site 320388012870 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 320388012871 putative iron binding site [ion binding]; other site 320388012872 Transposase domain (DUF772); Region: DUF772; pfam05598 320388012873 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388012874 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388012875 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 320388012876 Transglycosylase; Region: Transgly; pfam00912 320388012877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320388012878 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 320388012879 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 320388012880 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320388012881 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320388012882 shikimate kinase; Reviewed; Region: aroK; PRK00131 320388012883 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 320388012884 ADP binding site [chemical binding]; other site 320388012885 magnesium binding site [ion binding]; other site 320388012886 putative shikimate binding site; other site 320388012887 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 320388012888 active site 320388012889 dimer interface [polypeptide binding]; other site 320388012890 metal binding site [ion binding]; metal-binding site 320388012891 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 320388012892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320388012893 Zn2+ binding site [ion binding]; other site 320388012894 Mg2+ binding site [ion binding]; other site 320388012895 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 320388012896 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320388012897 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 320388012898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388012899 dimer interface [polypeptide binding]; other site 320388012900 conserved gate region; other site 320388012901 putative PBP binding loops; other site 320388012902 ABC-ATPase subunit interface; other site 320388012903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320388012904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388012905 dimer interface [polypeptide binding]; other site 320388012906 conserved gate region; other site 320388012907 putative PBP binding loops; other site 320388012908 ABC-ATPase subunit interface; other site 320388012909 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320388012910 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320388012911 Walker A/P-loop; other site 320388012912 ATP binding site [chemical binding]; other site 320388012913 Q-loop/lid; other site 320388012914 ABC transporter signature motif; other site 320388012915 Walker B; other site 320388012916 D-loop; other site 320388012917 H-loop/switch region; other site 320388012918 TOBE domain; Region: TOBE_2; pfam08402 320388012919 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 320388012920 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 320388012921 active site 320388012922 catalytic site [active] 320388012923 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320388012924 Transposase IS200 like; Region: Y1_Tnp; cl00848 320388012925 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 320388012926 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 320388012927 active site 320388012928 dimer interface [polypeptide binding]; other site 320388012929 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 320388012930 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 320388012931 active site 320388012932 FMN binding site [chemical binding]; other site 320388012933 substrate binding site [chemical binding]; other site 320388012934 3Fe-4S cluster binding site [ion binding]; other site 320388012935 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 320388012936 domain interface; other site 320388012937 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 320388012938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320388012939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320388012940 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 320388012941 amino acid carrier protein; Region: agcS; TIGR00835 320388012942 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 320388012943 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 320388012944 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 320388012945 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 320388012946 FAD dependent oxidoreductase; Region: DAO; pfam01266 320388012947 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 320388012948 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 320388012949 thiS-thiF/thiG interaction site; other site 320388012950 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 320388012951 ThiS interaction site; other site 320388012952 putative active site [active] 320388012953 tetramer interface [polypeptide binding]; other site 320388012954 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 320388012955 thiamine phosphate binding site [chemical binding]; other site 320388012956 active site 320388012957 pyrophosphate binding site [ion binding]; other site 320388012958 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320388012959 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 320388012960 Walker A/P-loop; other site 320388012961 ATP binding site [chemical binding]; other site 320388012962 Q-loop/lid; other site 320388012963 ABC transporter signature motif; other site 320388012964 Walker B; other site 320388012965 D-loop; other site 320388012966 H-loop/switch region; other site 320388012967 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 320388012968 Permease; Region: Permease; pfam02405 320388012969 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 320388012970 mce related protein; Region: MCE; pfam02470 320388012971 VacJ like lipoprotein; Region: VacJ; cl01073 320388012972 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 320388012973 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 320388012974 anti sigma factor interaction site; other site 320388012975 regulatory phosphorylation site [posttranslational modification]; other site 320388012976 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 320388012977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320388012978 Walker A/P-loop; other site 320388012979 ATP binding site [chemical binding]; other site 320388012980 Q-loop/lid; other site 320388012981 ABC transporter signature motif; other site 320388012982 Walker B; other site 320388012983 D-loop; other site 320388012984 H-loop/switch region; other site 320388012985 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320388012986 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320388012987 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 320388012988 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 320388012989 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 320388012990 hinge; other site 320388012991 active site 320388012992 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 320388012993 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 320388012994 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 320388012995 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 320388012996 NAD binding site [chemical binding]; other site 320388012997 dimerization interface [polypeptide binding]; other site 320388012998 product binding site; other site 320388012999 substrate binding site [chemical binding]; other site 320388013000 zinc binding site [ion binding]; other site 320388013001 catalytic residues [active] 320388013002 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 320388013003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388013004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388013005 homodimer interface [polypeptide binding]; other site 320388013006 catalytic residue [active] 320388013007 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 320388013008 putative active site pocket [active] 320388013009 4-fold oligomerization interface [polypeptide binding]; other site 320388013010 metal binding residues [ion binding]; metal-binding site 320388013011 3-fold/trimer interface [polypeptide binding]; other site 320388013012 MarC family integral membrane protein; Region: MarC; cl00919 320388013013 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 320388013014 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 320388013015 putative active site [active] 320388013016 oxyanion strand; other site 320388013017 catalytic triad [active] 320388013018 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 320388013019 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 320388013020 catalytic residues [active] 320388013021 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 320388013022 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 320388013023 substrate binding site [chemical binding]; other site 320388013024 glutamase interaction surface [polypeptide binding]; other site 320388013025 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 320388013026 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 320388013027 metal binding site [ion binding]; metal-binding site 320388013028 Predicted membrane protein [Function unknown]; Region: COG3671 320388013029 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 320388013030 nucleotide binding site/active site [active] 320388013031 HIT family signature motif; other site 320388013032 catalytic residue [active] 320388013033 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 320388013034 sec-independent translocase; Provisional; Region: tatB; PRK01919 320388013035 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 320388013036 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 320388013037 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320388013038 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320388013039 protein binding site [polypeptide binding]; other site 320388013040 Uncharacterized conserved protein [Function unknown]; Region: COG0327 320388013041 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 320388013042 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 320388013043 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 320388013044 [2Fe-2S] cluster binding site [ion binding]; other site 320388013045 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 320388013046 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 320388013047 Qi binding site; other site 320388013048 intrachain domain interface; other site 320388013049 interchain domain interface [polypeptide binding]; other site 320388013050 heme bH binding site [chemical binding]; other site 320388013051 heme bL binding site [chemical binding]; other site 320388013052 Qo binding site; other site 320388013053 interchain domain interface [polypeptide binding]; other site 320388013054 intrachain domain interface; other site 320388013055 Qi binding site; other site 320388013056 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 320388013057 Qo binding site; other site 320388013058 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 320388013059 stringent starvation protein A; Provisional; Region: sspA; PRK09481 320388013060 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 320388013061 C-terminal domain interface [polypeptide binding]; other site 320388013062 putative GSH binding site (G-site) [chemical binding]; other site 320388013063 dimer interface [polypeptide binding]; other site 320388013064 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 320388013065 dimer interface [polypeptide binding]; other site 320388013066 N-terminal domain interface [polypeptide binding]; other site 320388013067 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 320388013068 Phage-related protein [Function unknown]; Region: COG4695; cl01923 320388013069 Transposase; Region: HTH_Tnp_1; pfam01527 320388013070 HTH-like domain; Region: HTH_21; pfam13276 320388013071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013072 Integrase core domain; Region: rve; pfam00665 320388013073 Integrase core domain; Region: rve_3; pfam13683 320388013074 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 320388013075 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 320388013076 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 320388013077 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 320388013078 DNA binding residues [nucleotide binding] 320388013079 putative dimer interface [polypeptide binding]; other site 320388013080 putative metal binding residues [ion binding]; other site 320388013081 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320388013082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388013083 S-adenosylmethionine binding site [chemical binding]; other site 320388013084 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 320388013085 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 320388013086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388013087 membrane-bound complex binding site; other site 320388013088 hinge residues; other site 320388013089 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320388013090 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320388013091 Walker A/P-loop; other site 320388013092 ATP binding site [chemical binding]; other site 320388013093 Q-loop/lid; other site 320388013094 ABC transporter signature motif; other site 320388013095 Walker B; other site 320388013096 D-loop; other site 320388013097 H-loop/switch region; other site 320388013098 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320388013099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320388013100 dimer interface [polypeptide binding]; other site 320388013101 conserved gate region; other site 320388013102 putative PBP binding loops; other site 320388013103 ABC-ATPase subunit interface; other site 320388013104 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320388013105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388013106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388013107 dimer interface [polypeptide binding]; other site 320388013108 phosphorylation site [posttranslational modification] 320388013109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388013110 ATP binding site [chemical binding]; other site 320388013111 Mg2+ binding site [ion binding]; other site 320388013112 G-X-G motif; other site 320388013113 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 320388013114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388013115 active site 320388013116 phosphorylation site [posttranslational modification] 320388013117 intermolecular recognition site; other site 320388013118 dimerization interface [polypeptide binding]; other site 320388013119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388013120 DNA binding site [nucleotide binding] 320388013121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388013122 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388013123 trimer interface [polypeptide binding]; other site 320388013124 eyelet of channel; other site 320388013125 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 320388013126 DNA methylase; Region: N6_N4_Mtase; pfam01555 320388013127 DNA methylase; Region: N6_N4_Mtase; cl17433 320388013128 Restriction endonuclease [Defense mechanisms]; Region: COG3587 320388013129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388013130 ATP binding site [chemical binding]; other site 320388013131 putative Mg++ binding site [ion binding]; other site 320388013132 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320388013133 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320388013134 trimer interface [polypeptide binding]; other site 320388013135 eyelet of channel; other site 320388013136 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320388013137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320388013138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388013139 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388013140 Walker A/P-loop; other site 320388013141 ATP binding site [chemical binding]; other site 320388013142 Q-loop/lid; other site 320388013143 ABC transporter signature motif; other site 320388013144 Walker B; other site 320388013145 D-loop; other site 320388013146 H-loop/switch region; other site 320388013147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388013148 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388013149 Walker A/P-loop; other site 320388013150 ATP binding site [chemical binding]; other site 320388013151 Q-loop/lid; other site 320388013152 ABC transporter signature motif; other site 320388013153 Walker B; other site 320388013154 D-loop; other site 320388013155 H-loop/switch region; other site 320388013156 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388013157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388013158 TM-ABC transporter signature motif; other site 320388013159 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388013160 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388013161 TM-ABC transporter signature motif; other site 320388013162 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320388013163 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 320388013164 putative ligand binding site [chemical binding]; other site 320388013165 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388013166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388013167 NAD(P) binding site [chemical binding]; other site 320388013168 catalytic residues [active] 320388013169 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 320388013170 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 320388013171 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320388013172 classical (c) SDRs; Region: SDR_c; cd05233 320388013173 NAD(P) binding site [chemical binding]; other site 320388013174 active site 320388013175 choline dehydrogenase; Validated; Region: PRK02106 320388013176 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 320388013177 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388013178 Predicted transcriptional regulators [Transcription]; Region: COG1695 320388013179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 320388013180 Predicted membrane protein [Function unknown]; Region: COG4709 320388013181 HTH-like domain; Region: HTH_21; pfam13276 320388013182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013183 Integrase core domain; Region: rve; pfam00665 320388013184 Integrase core domain; Region: rve_3; pfam13683 320388013185 Transposase; Region: HTH_Tnp_1; pfam01527 320388013186 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 320388013187 Int/Topo IB signature motif; other site 320388013188 Cytochrome c; Region: Cytochrom_C; cl11414 320388013189 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 320388013190 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 320388013191 Part of AAA domain; Region: AAA_19; pfam13245 320388013192 Family description; Region: UvrD_C_2; pfam13538 320388013193 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 320388013194 oxyanion hole [active] 320388013195 active site 320388013196 catalytic triad [active] 320388013197 putative oxidoreductase; Provisional; Region: PRK11579 320388013198 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320388013199 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320388013200 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 320388013201 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 320388013202 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 320388013203 lipoyl attachment site [posttranslational modification]; other site 320388013204 glycine dehydrogenase; Provisional; Region: PRK05367 320388013205 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 320388013206 tetramer interface [polypeptide binding]; other site 320388013207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388013208 catalytic residue [active] 320388013209 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 320388013210 tetramer interface [polypeptide binding]; other site 320388013211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388013212 catalytic residue [active] 320388013213 Alginate lyase; Region: Alginate_lyase; pfam05426 320388013214 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 320388013215 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 320388013216 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 320388013217 thiamine pyrophosphate protein; Validated; Region: PRK08199 320388013218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320388013219 PYR/PP interface [polypeptide binding]; other site 320388013220 dimer interface [polypeptide binding]; other site 320388013221 TPP binding site [chemical binding]; other site 320388013222 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320388013223 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 320388013224 TPP-binding site [chemical binding]; other site 320388013225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320388013226 Helix-turn-helix domain; Region: HTH_18; pfam12833 320388013227 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 320388013228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320388013229 NAD(P) binding site [chemical binding]; other site 320388013230 catalytic residues [active] 320388013231 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 320388013232 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 320388013233 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 320388013234 Transposase domain (DUF772); Region: DUF772; pfam05598 320388013235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388013236 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388013237 ethanolamine permease; Region: 2A0305; TIGR00908 320388013238 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 320388013239 Acyltransferase family; Region: Acyl_transf_3; pfam01757 320388013240 Conserved TM helix; Region: TM_helix; pfam05552 320388013241 Conserved TM helix; Region: TM_helix; pfam05552 320388013242 Conserved TM helix; Region: TM_helix; pfam05552 320388013243 Double zinc ribbon; Region: DZR; pfam12773 320388013244 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 320388013245 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 320388013246 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320388013247 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320388013248 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 320388013249 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 320388013250 DNA binding residues [nucleotide binding] 320388013251 dimer interface [polypeptide binding]; other site 320388013252 putative metal binding site [ion binding]; other site 320388013253 Predicted transcriptional regulators [Transcription]; Region: COG1695 320388013254 Transcriptional regulator PadR-like family; Region: PadR; cl17335 320388013255 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 320388013256 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320388013257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388013258 substrate binding pocket [chemical binding]; other site 320388013259 membrane-bound complex binding site; other site 320388013260 hinge residues; other site 320388013261 putative aminotransferase; Provisional; Region: PRK12414 320388013262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320388013263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388013264 homodimer interface [polypeptide binding]; other site 320388013265 catalytic residue [active] 320388013266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320388013267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320388013268 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 320388013269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388013270 active site 320388013271 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 320388013272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388013273 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 320388013274 acyl-activating enzyme (AAE) consensus motif; other site 320388013275 acyl-activating enzyme (AAE) consensus motif; other site 320388013276 putative AMP binding site [chemical binding]; other site 320388013277 putative active site [active] 320388013278 putative CoA binding site [chemical binding]; other site 320388013279 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320388013280 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320388013281 dimerization interface [polypeptide binding]; other site 320388013282 ligand binding site [chemical binding]; other site 320388013283 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 320388013284 Predicted transcriptional regulator [Transcription]; Region: COG3905 320388013285 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 320388013286 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 320388013287 Glutamate binding site [chemical binding]; other site 320388013288 NAD binding site [chemical binding]; other site 320388013289 catalytic residues [active] 320388013290 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320388013291 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 320388013292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320388013293 ATP binding site [chemical binding]; other site 320388013294 putative Mg++ binding site [ion binding]; other site 320388013295 nucleotide binding region [chemical binding]; other site 320388013296 helicase superfamily c-terminal domain; Region: HELICc; smart00490 320388013297 ATP-binding site [chemical binding]; other site 320388013298 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 320388013299 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 320388013300 substrate binding site [chemical binding]; other site 320388013301 active site 320388013302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320388013303 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320388013304 substrate binding pocket [chemical binding]; other site 320388013305 membrane-bound complex binding site; other site 320388013306 hinge residues; other site 320388013307 CoA binding domain; Region: CoA_binding; cl17356 320388013308 AMP-binding domain protein; Validated; Region: PRK08315 320388013309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320388013310 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 320388013311 acyl-activating enzyme (AAE) consensus motif; other site 320388013312 putative AMP binding site [chemical binding]; other site 320388013313 putative active site [active] 320388013314 putative CoA binding site [chemical binding]; other site 320388013315 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 320388013316 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 320388013317 gamma subunit interface [polypeptide binding]; other site 320388013318 epsilon subunit interface [polypeptide binding]; other site 320388013319 LBP interface [polypeptide binding]; other site 320388013320 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 320388013321 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320388013322 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 320388013323 alpha subunit interaction interface [polypeptide binding]; other site 320388013324 Walker A motif; other site 320388013325 ATP binding site [chemical binding]; other site 320388013326 Walker B motif; other site 320388013327 inhibitor binding site; inhibition site 320388013328 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320388013329 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 320388013330 core domain interface [polypeptide binding]; other site 320388013331 delta subunit interface [polypeptide binding]; other site 320388013332 epsilon subunit interface [polypeptide binding]; other site 320388013333 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 320388013334 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320388013335 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 320388013336 beta subunit interaction interface [polypeptide binding]; other site 320388013337 Walker A motif; other site 320388013338 ATP binding site [chemical binding]; other site 320388013339 Walker B motif; other site 320388013340 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320388013341 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 320388013342 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 320388013343 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 320388013344 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 320388013345 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 320388013346 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 320388013347 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 320388013348 ATP synthase I chain; Region: ATP_synt_I; cl09170 320388013349 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 320388013350 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 320388013351 transmembrane helices; other site 320388013352 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 320388013353 ParB-like nuclease domain; Region: ParBc; pfam02195 320388013354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 320388013355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320388013356 P-loop; other site 320388013357 Magnesium ion binding site [ion binding]; other site 320388013358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320388013359 Magnesium ion binding site [ion binding]; other site 320388013360 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 320388013361 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 320388013362 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 320388013363 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 320388013364 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 320388013365 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 320388013366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388013367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388013368 Walker A/P-loop; other site 320388013369 ATP binding site [chemical binding]; other site 320388013370 Q-loop/lid; other site 320388013371 ABC transporter signature motif; other site 320388013372 Walker B; other site 320388013373 D-loop; other site 320388013374 H-loop/switch region; other site 320388013375 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388013376 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388013377 TM-ABC transporter signature motif; other site 320388013378 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388013379 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388013380 Walker A/P-loop; other site 320388013381 ATP binding site [chemical binding]; other site 320388013382 Q-loop/lid; other site 320388013383 ABC transporter signature motif; other site 320388013384 Walker B; other site 320388013385 D-loop; other site 320388013386 H-loop/switch region; other site 320388013387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388013388 TM-ABC transporter signature motif; other site 320388013389 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320388013390 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 320388013391 putative ligand binding site [chemical binding]; other site 320388013392 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320388013393 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320388013394 TM-ABC transporter signature motif; other site 320388013395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320388013396 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320388013397 TM-ABC transporter signature motif; other site 320388013398 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320388013399 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 320388013400 putative ligand binding site [chemical binding]; other site 320388013401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320388013402 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320388013403 Walker A/P-loop; other site 320388013404 ATP binding site [chemical binding]; other site 320388013405 Q-loop/lid; other site 320388013406 ABC transporter signature motif; other site 320388013407 Walker B; other site 320388013408 D-loop; other site 320388013409 H-loop/switch region; other site 320388013410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320388013411 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320388013412 Walker A/P-loop; other site 320388013413 ATP binding site [chemical binding]; other site 320388013414 Q-loop/lid; other site 320388013415 ABC transporter signature motif; other site 320388013416 Walker B; other site 320388013417 D-loop; other site 320388013418 H-loop/switch region; other site 320388013419 choline dehydrogenase; Validated; Region: PRK02106 320388013420 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320388013421 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 320388013422 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 320388013423 tetrameric interface [polypeptide binding]; other site 320388013424 NAD binding site [chemical binding]; other site 320388013425 catalytic residues [active] 320388013426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388013427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388013428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320388013429 dimerization interface [polypeptide binding]; other site 320388013430 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 320388013431 putative active site [active] 320388013432 putative metal binding residues [ion binding]; other site 320388013433 signature motif; other site 320388013434 putative triphosphate binding site [ion binding]; other site 320388013435 dimer interface [polypeptide binding]; other site 320388013436 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388013437 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320388013438 putative DNA binding site [nucleotide binding]; other site 320388013439 putative Zn2+ binding site [ion binding]; other site 320388013440 AsnC family; Region: AsnC_trans_reg; pfam01037 320388013441 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 320388013442 cofactor binding site; other site 320388013443 metal binding site [ion binding]; metal-binding site 320388013444 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 320388013445 aromatic arch; other site 320388013446 DCoH dimer interaction site [polypeptide binding]; other site 320388013447 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 320388013448 DCoH tetramer interaction site [polypeptide binding]; other site 320388013449 substrate binding site [chemical binding]; other site 320388013450 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 320388013451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320388013452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388013453 active site 320388013454 phosphorylation site [posttranslational modification] 320388013455 intermolecular recognition site; other site 320388013456 dimerization interface [polypeptide binding]; other site 320388013457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320388013458 DNA binding site [nucleotide binding] 320388013459 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320388013460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320388013461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320388013462 dimer interface [polypeptide binding]; other site 320388013463 phosphorylation site [posttranslational modification] 320388013464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388013465 ATP binding site [chemical binding]; other site 320388013466 Mg2+ binding site [ion binding]; other site 320388013467 G-X-G motif; other site 320388013468 Proteins containing SET domain [General function prediction only]; Region: COG2940 320388013469 SET domain; Region: SET; pfam00856 320388013470 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320388013471 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 320388013472 active site 320388013473 FMN binding site [chemical binding]; other site 320388013474 substrate binding site [chemical binding]; other site 320388013475 homotetramer interface [polypeptide binding]; other site 320388013476 catalytic residue [active] 320388013477 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 320388013478 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 320388013479 catalytic triad [active] 320388013480 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320388013481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388013482 dimerization interface [polypeptide binding]; other site 320388013483 putative DNA binding site [nucleotide binding]; other site 320388013484 putative Zn2+ binding site [ion binding]; other site 320388013485 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 320388013486 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 320388013487 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 320388013488 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 320388013489 Uncharacterized conserved protein [Function unknown]; Region: COG4121 320388013490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320388013491 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320388013492 IHF dimer interface [polypeptide binding]; other site 320388013493 IHF - DNA interface [nucleotide binding]; other site 320388013494 Transposase domain (DUF772); Region: DUF772; pfam05598 320388013495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388013496 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388013497 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 320388013498 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 320388013499 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320388013500 active site 320388013501 catalytic site [active] 320388013502 substrate binding site [chemical binding]; other site 320388013503 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 320388013504 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320388013505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320388013506 putative DNA binding site [nucleotide binding]; other site 320388013507 putative Zn2+ binding site [ion binding]; other site 320388013508 AsnC family; Region: AsnC_trans_reg; pfam01037 320388013509 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 320388013510 Cation efflux family; Region: Cation_efflux; pfam01545 320388013511 H-NS histone family; Region: Histone_HNS; pfam00816 320388013512 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388013513 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 320388013514 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320388013515 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320388013516 dimerization interface [polypeptide binding]; other site 320388013517 ligand binding site [chemical binding]; other site 320388013518 HTH-like domain; Region: HTH_21; pfam13276 320388013519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013520 Integrase core domain; Region: rve; pfam00665 320388013521 Integrase core domain; Region: rve_3; pfam13683 320388013522 Transposase; Region: HTH_Tnp_1; pfam01527 320388013523 Dienelactone hydrolase family; Region: DLH; pfam01738 320388013524 amidase; Provisional; Region: PRK07869 320388013525 Amidase; Region: Amidase; cl11426 320388013526 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 320388013527 FAD binding site [chemical binding]; other site 320388013528 Predicted membrane protein [Function unknown]; Region: COG1950 320388013529 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 320388013530 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 320388013531 homotetramer interface [polypeptide binding]; other site 320388013532 ligand binding site [chemical binding]; other site 320388013533 catalytic site [active] 320388013534 NAD binding site [chemical binding]; other site 320388013535 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 320388013536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320388013537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320388013538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320388013539 DNA binding residues [nucleotide binding] 320388013540 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320388013541 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 320388013542 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320388013543 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 320388013544 FHIPEP family; Region: FHIPEP; pfam00771 320388013545 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 320388013546 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 320388013547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320388013548 dimer interface [polypeptide binding]; other site 320388013549 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 320388013550 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 320388013551 chemotaxis regulator CheZ; Provisional; Region: PRK11166 320388013552 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 320388013553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388013554 active site 320388013555 phosphorylation site [posttranslational modification] 320388013556 intermolecular recognition site; other site 320388013557 dimerization interface [polypeptide binding]; other site 320388013558 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 320388013559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388013560 active site 320388013561 phosphorylation site [posttranslational modification] 320388013562 intermolecular recognition site; other site 320388013563 dimerization interface [polypeptide binding]; other site 320388013564 CheB methylesterase; Region: CheB_methylest; pfam01339 320388013565 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 320388013566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320388013567 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 320388013568 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 320388013569 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 320388013570 dimer interface [polypeptide binding]; other site 320388013571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388013572 dimerization interface [polypeptide binding]; other site 320388013573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388013574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388013575 dimer interface [polypeptide binding]; other site 320388013576 putative CheW interface [polypeptide binding]; other site 320388013577 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 320388013578 putative CheA interaction surface; other site 320388013579 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 320388013580 putative binding surface; other site 320388013581 active site 320388013582 CheY binding; Region: CheY-binding; pfam09078 320388013583 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 320388013584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320388013585 ATP binding site [chemical binding]; other site 320388013586 Mg2+ binding site [ion binding]; other site 320388013587 G-X-G motif; other site 320388013588 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 320388013589 Response regulator receiver domain; Region: Response_reg; pfam00072 320388013590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320388013591 active site 320388013592 phosphorylation site [posttranslational modification] 320388013593 intermolecular recognition site; other site 320388013594 dimerization interface [polypeptide binding]; other site 320388013595 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320388013596 ligand binding site [chemical binding]; other site 320388013597 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 320388013598 flagellar motor protein MotA; Validated; Region: PRK09110 320388013599 transcriptional activator FlhC; Provisional; Region: PRK12722 320388013600 transcriptional activator FlhD; Provisional; Region: PRK02909 320388013601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320388013602 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320388013603 putative ADP-binding pocket [chemical binding]; other site 320388013604 H-NS histone family; Region: Histone_HNS; pfam00816 320388013605 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320388013606 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 320388013607 amphipathic channel; other site 320388013608 Asn-Pro-Ala signature motifs; other site 320388013609 putative hydrolase; Provisional; Region: PRK10976 320388013610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388013611 active site 320388013612 motif I; other site 320388013613 motif II; other site 320388013614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320388013615 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 320388013616 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 320388013617 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320388013618 flagellin; Reviewed; Region: PRK08869 320388013619 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320388013620 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 320388013621 flagellar capping protein; Reviewed; Region: fliD; PRK08032 320388013622 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 320388013623 Tetratricopeptide repeat; Region: TPR_16; pfam13432 320388013624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388013625 TPR motif; other site 320388013626 binding surface 320388013627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388013628 binding surface 320388013629 TPR motif; other site 320388013630 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 320388013631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320388013632 TPR motif; other site 320388013633 binding surface 320388013634 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 320388013635 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320388013636 inhibitor-cofactor binding pocket; inhibition site 320388013637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320388013638 catalytic residue [active] 320388013639 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320388013640 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320388013641 dimer interface [polypeptide binding]; other site 320388013642 active site 320388013643 CoA binding pocket [chemical binding]; other site 320388013644 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 320388013645 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320388013646 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320388013647 dimer interface [polypeptide binding]; other site 320388013648 active site 320388013649 CoA binding pocket [chemical binding]; other site 320388013650 short chain dehydrogenase; Provisional; Region: PRK06500 320388013651 classical (c) SDRs; Region: SDR_c; cd05233 320388013652 NAD(P) binding site [chemical binding]; other site 320388013653 active site 320388013654 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 320388013655 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 320388013656 putative trimer interface [polypeptide binding]; other site 320388013657 putative CoA binding site [chemical binding]; other site 320388013658 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320388013659 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320388013660 [2Fe-2S] cluster binding site [ion binding]; other site 320388013661 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320388013662 alpha subunit interface [polypeptide binding]; other site 320388013663 active site 320388013664 substrate binding site [chemical binding]; other site 320388013665 Fe binding site [ion binding]; other site 320388013666 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320388013667 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320388013668 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 320388013669 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 320388013670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 320388013671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 320388013672 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 320388013673 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 320388013674 Cache domain; Region: Cache_1; pfam02743 320388013675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320388013676 dimerization interface [polypeptide binding]; other site 320388013677 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320388013678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320388013679 dimer interface [polypeptide binding]; other site 320388013680 putative CheW interface [polypeptide binding]; other site 320388013681 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320388013682 FAD binding domain; Region: FAD_binding_4; pfam01565 320388013683 Berberine and berberine like; Region: BBE; pfam08031 320388013684 Chitin binding domain; Region: Chitin_bind_3; pfam03067 320388013685 Transposase; Region: HTH_Tnp_1; pfam01527 320388013686 HTH-like domain; Region: HTH_21; pfam13276 320388013687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013688 Integrase core domain; Region: rve; pfam00665 320388013689 Integrase core domain; Region: rve_3; pfam13683 320388013690 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320388013691 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320388013692 putative di-iron ligands [ion binding]; other site 320388013693 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320388013694 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 320388013695 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 320388013696 conserved cys residue [active] 320388013697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320388013698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320388013699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320388013700 active site 320388013701 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320388013702 active site 320388013703 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320388013704 active site 320388013705 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320388013706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320388013707 substrate binding site [chemical binding]; other site 320388013708 oxyanion hole (OAH) forming residues; other site 320388013709 trimer interface [polypeptide binding]; other site 320388013710 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320388013711 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320388013712 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320388013713 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320388013714 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 320388013715 HTH-like domain; Region: HTH_21; pfam13276 320388013716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013717 Integrase core domain; Region: rve; pfam00665 320388013718 Integrase core domain; Region: rve_3; pfam13683 320388013719 Transposase; Region: HTH_Tnp_1; pfam01527 320388013720 FliP family; Region: FliP; cl00593 320388013721 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 320388013722 flagellar motor switch protein; Validated; Region: fliN; PRK05698 320388013723 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 320388013724 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 320388013725 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 320388013726 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 320388013727 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 320388013728 LrgB-like family; Region: LrgB; cl00596 320388013729 LrgA family; Region: LrgA; pfam03788 320388013730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320388013731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320388013732 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 320388013733 putative dimerization interface [polypeptide binding]; other site 320388013734 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320388013735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388013736 putative substrate translocation pore; other site 320388013737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320388013738 MarR family; Region: MarR_2; cl17246 320388013739 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320388013740 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320388013741 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 320388013742 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 320388013743 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 320388013744 GspL periplasmic domain; Region: GspL_C; pfam12693 320388013745 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 320388013746 type II secretion system protein I; Region: gspI; TIGR01707 320388013747 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 320388013748 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 320388013749 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320388013750 Type II transport protein GspH; Region: GspH; pfam12019 320388013751 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320388013752 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 320388013753 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 320388013754 type II secretion system protein F; Region: GspF; TIGR02120 320388013755 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388013756 Ceramidase; Region: Ceramidase; pfam05875 320388013757 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320388013758 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 320388013759 type II secretion system protein E; Region: type_II_gspE; TIGR02533 320388013760 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 320388013761 Walker A motif; other site 320388013762 ATP binding site [chemical binding]; other site 320388013763 Walker B motif; other site 320388013764 type II secretion system protein D; Region: type_II_gspD; TIGR02517 320388013765 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320388013766 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320388013767 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320388013768 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 320388013769 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320388013770 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320388013771 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320388013772 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320388013773 catalytic residue [active] 320388013774 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 320388013775 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 320388013776 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 320388013777 Transposase domain (DUF772); Region: DUF772; pfam05598 320388013778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320388013779 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320388013780 Transposase; Region: HTH_Tnp_1; pfam01527 320388013781 HTH-like domain; Region: HTH_21; pfam13276 320388013782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320388013783 Integrase core domain; Region: rve; pfam00665 320388013784 Integrase core domain; Region: rve_3; pfam13683 320388013785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 320388013786 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320388013787 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320388013788 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388013789 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320388013790 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 320388013791 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320388013792 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 320388013793 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320388013794 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 320388013795 substrate binding site [chemical binding]; other site 320388013796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320388013797 active site 320388013798 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 320388013799 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320388013800 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320388013801 putative NAD(P) binding site [chemical binding]; other site 320388013802 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280